KR20160119548A - Skin whitening composition comprising Scrophularia buergeriana hot water extract as an active ingredient - Google Patents
Skin whitening composition comprising Scrophularia buergeriana hot water extract as an active ingredient Download PDFInfo
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- KR20160119548A KR20160119548A KR1020150048362A KR20150048362A KR20160119548A KR 20160119548 A KR20160119548 A KR 20160119548A KR 1020150048362 A KR1020150048362 A KR 1020150048362A KR 20150048362 A KR20150048362 A KR 20150048362A KR 20160119548 A KR20160119548 A KR 20160119548A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Abstract
The present invention relates to a skin whitening pharmaceutical composition or skin whitening cosmetic composition having an effect of alleviating and improving spots and freckles containing an extract of Hyacinthis hot water or a pharmaceutically acceptable carrier or an additive for cosmetic, And is characterized by high safety as a natural product. More specifically, it is characterized by having a function of whitening the skin formed with melanin from ultraviolet rays of the sun and inhibiting the formation of tyrosinase, Skin external preparations, cosmetics, and the like.
Description
The present invention relates to a method for producing scrophularia The present invention relates to a skin whitening composition containing hot water extract, more specifically to a cosmetic composition for whitening skin, which comprises an extract of hot water.
The human epidermis receives damage from ultraviolet rays and is stimulated. There are several enzymes involved in the synthesis of melanin present in the melanosome, tyrosinase. Tyrosinase is an enzyme involved in the crucial initial rate determining step in the melanin biosynthetic pathway and tyrosinase induces the oxidation of tyrosine, a protein in the melanocyte.
As a result of this mechanism, melanin is synthesized by tyrosine oxidized in the melanosome of the melanocyte of the basal layer at the bottom of the skin. Tyrosine is oxidized to the next DOFA quinone by DOFA.
The pigment produced in human epidermis is divided into two major parts. TRP-1, which is known to eumelanogenesis, which produces brown and black pigments, and TRP-2, which catalyzes DHICA reaction from DOFA chromium, a melanin intermediate, Two enzymes are involved. Pheomelanogenesis, which produces yellow and red pigments, is divided into two mechanisms, which involve the sulfur-containing reactions such as cysteine and glutathione, the sulfur-containing amino acids.
Because the skin continues to form melanin due to UV radiation from the sun, it must be made to continue to whiten. In addition, there are hormones that prevent whitening from continuing. There is no way to completely inhibit the activity of tyrosinase due to the actions of the sex hormones estrogen, progesterone and the like. Therefore, skin whitening efficacy can be expected by continuously using whitening functional cosmetics with little irritation. Another problem is that it is difficult to remove only the melanin, which is a high molecular substance, so natural products are used as a method of inhibiting tyrosinase, an enzyme involved in the initial rate determining step. Continuously use whitening functional cosmetics to maintain whitening.
The hot water extract according to the present invention contains alkaloids, sugars, sterols, amino acids (such as L-asparagine), fatty acids (oleic acid, stearic acid, etc.), trace amounts of essential oils, carotene and the like.
The pharmacological action of northern ginseng is as follows: First, intravenous injection into rabbits anesthetized with fluidized X is performed first, then the blood pressure slightly increases first and then goes down again. Intravenous injection of a large amount lowers blood pressure. Injections, ethanol extracts, and bath salts have a distinct effect of lowering blood pressure when injected into anesthetized dogs, cats, and rabbits.
In dogs with healthy dogs and elongated hypertension, oral administration of 2 g / Kg of Tangjeong twice a day is effective in lowering blood pressure, and the effect on dogs with hypertensive hypertension is more pronounced than in healthy dogs. It has been relaxed. When infused into the heart of the toad, a small dose of fluid x was shown to have a cardiotonic effect, but it increased the dose and caused an addiction. The toad of the toad also showed expansion of the blood vessels.
Other actions include subcutaneous injections (g / Kg) of flow X in normal rabbits and blood glucose levels dropped slightly. The p-methoxycinnamic acid extracted from the roots showed antipyretic activity against the rabbit fever caused by typhus vaccine. X in In vitro there is antifungal activity. It contains saponin, which has remarkable hemolytic action and causes local irritation. In addition, the total flavonoid glycoside agglutinin contained in S. gossheimi , an inbred plant, lowers the blood pressure of the animal, decreases the permeability of capillaries, and promotes the secretion of bile.
S. nodosa is known to have sedation, coercion, vasodilatation, and vasodilatation and anticonvulsant action (Chinese medicine, 1998). Also recently, E-harpagoside , p-methoxycinnamic acid, and p-methoxycinnamic acid methyl ester, which are known to contain p-methoxycinnamic acid. (E-harpagoside), an iridoid glycoside-based E-harpagoside, was found to have an analgesic and anti-inflammatory effect (S. Chrubasik, S. Pollak and A. Black, 2002). Other efficacies have been reported to have cranial nerve-protective activity. (Study title: Studies on the active ingredients of cynomolgus cynomolgus neurons and its mechanism, 2001-2003) It was also investigated that α-glucosidase inhibitory activity which can delay the antioxidant activity and glucose uptake of the extract (Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants, 2013)
Meanwhile, a patent for a composition for preventing and treating a cognitive dysfunction-related disease containing an extract of hongshen as an active ingredient (Korean Patent No. 890,179), a cognitive dysfunction-related disease (Korean Patent No. 890,177) for a composition for prevention and treatment, a patent for a composition for prevention and treatment of immune enhancement and atherosclerosis including a ginseng extract (Korean Patent No. 535,267), a ginseng having excellent anti- (Korean Patent No. 597,612), a patent for Korean ginseng extract having excellent anti-aging activity and a composition containing the same (Korea Patent No. 535,266), a wax extract having excellent wrinkle and improving activity (Korean Patent Laid-Open No. 2004-0074697), an antiallergic agent containing an extract of ginseng Etc. Patent Publication in water (Korea Patent Publication No. 2011-0095765 call) exists.
The present invention relates to a skin whitening composition containing a ginseng extract having an effect of inhibiting melanin production. Currently, there is an effort to prevent stains or freckles from appearing on the skin by melanin. As a natural extract having a whitening effect that has been studied in the past, there are known omija, chrysanthemum, and dermis. In addition to the natural extracts known to have a whitening effect as described above, the present invention demonstrates that whitening effect of ginseng shows whitening effect, and it is important to develop a skin whitening agent using ginseng extract. The whitening agent containing the extract of ginseng according to the present invention is advantageous in that it can provide a highly safe skin whitening agent.
The present invention provides a composition for skin whitening, a pharmaceutical composition, an external preparation for skin or a cosmetic composition, which comprises an extract of Hyosung, which is a natural extract as a skin whitening agent, to improve stain or freckles caused by aging or UV rays on the skin.
The present invention provides a skin whitening composition containing an extract of moss ginseng as an active ingredient to provide a natural product as an active ingredient and thus has high safety and excellent tyrosinase inhibitory activity and is free from cytotoxicity, Compositions useful for improvement, pharmaceutical compositions, external preparations for skin and cosmetic compositions can be provided.
The hot spring water extract of the present invention inhibited tyrosinase and did not show cytotoxicity in melanoma cell of B16-F10 melanoma cell. The above-mentioned effect is exhibited, and can be usefully used for mitigating and improving spots and freckles.
FIG. 1 shows the results of EZ-cytoximetry. As shown in FIG. 1, when the proliferation rate was 100.00% when the hot water extract was not treated, B16-F10 melanoma cells (200 .mu.g / ) Were alive.
FIG. 2 shows the results of measuring the effect on the inhibition of tyrosinase activity in vitro. When the inhibition rate of tyrosinase activity when the ginseng hot water extract was not treated was taken as 100.00%, tyrosine When the tyrosinase inhibition assay was used, the content of dopaquinone was decreased. In the tyrosinase inhibition assay, the extract of Hyosung hot water showed a tendency to decrease by about 20% from 25 (μg / mL) concentration compared to the control. The inhibition rate was significantly lower than that of untreated hot water extract. As a result, the content of dopaquinone tended to decrease with the concentration of the hot water extract of Hyosung, and it was confirmed that the tyrosinase was inhibited by the hot water extract of Hyosung.
The present invention relates to a natural product composition for skin whitening, spots, freckles and alleviating freckles, which is characterized by inhibiting the formation of melanin containing an extract of hot water of moss ginseng as an active ingredient. Since the composition of the present invention contains a component extracted from a natural product extract or a derivative thereof as an active ingredient, it has almost no toxicity and is harmless to human body.
In one embodiment of the present invention, the ginseng is a perennial herb that grows in the mountain area, the scientific name is Scrophularia buergeriana Miq. The ginseng according to the present invention is also referred to as "heavy", "modern", "鬼 藏", and "馬 馬".
Scrophularia ningpoensis Hemsl. In addition, the roots of Scrophularia buergeriana Miq are also common in the northern part of China. Its characteristic is a watery flower bed, the corolla is yellowish green, the leaves are thin and the wet soil is good.
The pharmaceutical dosage form of the hot water extract according to the present invention can be used in the form of a combination with a pharmaceutically acceptable carrier thereof and can be used alone or in combination with other pharmacologically active compounds as well as in a suitable combination have.
In one embodiment according to the present invention, the pharmaceutical composition is characterized by inhibiting melanin formation by alleviating and improving spots and freckles.
In one embodiment according to the present invention, the pharmaceutical composition inhibits melanin genesis reaction (melanogenesis reaction) and inhibits melanogenesis. There is provided a natural product composition for skin whitening, spots, freckles and alleviating freckles .
In one embodiment according to the present invention, the pharmaceutical composition inhibits melanin formation and thus exhibits skin whitening or spots, freckles and alleviating effects. It is possible to suppress the formation of melanin generated from the UV of the sun in particular.
In one embodiment according to the present invention, the ginseng extract may be from 25 μg / mL to 100 μg / mL on a dry weight basis. The ginseng extract can be used for each concentration by using 100 mg / ml, which is dissolved in 1 ml of 0.1 g dry weight. In one embodiment according to the present invention, the ability to inhibit tyrosinase from 25 μg / ml.
The pharmaceutical composition of the present invention may comprise a pharmaceutically acceptable carrier. The composition comprising a pharmaceutically acceptable carrier can be of various oral or parenteral formulations. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used.
Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used as the non-aqueous solvent and suspension agent.
In one embodiment of the present invention, the present invention provides an external preparation for skin preventing or alleviating spots and freckles, which comprises an extract of Angelica gigas Nakai as an active ingredient.
In one embodiment of the present invention, the external preparation for skin is formulated into any one selected from the group consisting of ointments, creams, lotions, liquids, dressings, patches, foams, tapes, aerosols, external powders and spraying agents .
For example, 0.01 to 1 w / v%, 0.01 to 2 w / v%, 0.01 to 2 w / v% in the case of ointment, cream, gel and lotion, 0.01 To 2 w / v%, and in the case of topical powders, 0.01 to 2 w / v%.
Other ingredients than the active ingredient of the formulation of the present invention may be any ingredient commonly used in external preparations. In the case of ointments, creams, gels and lotions, there may be used white petrolatum (vaseline), yellow petrolatum, lanolin, purified beeswax, cetanol, stearyl alcohol, stearic acid, hydrogenated oil, hydrocarbon gel, polyethylene glycol, liquid paraffin and squalane A mechanism such as; Oleic acid, isopropyl myristate, glycerol triisooctanoate, crotamitone, diethyl sebacate, diisopropyl sebacate, diisopropyl adipate, hexyllaurate, fatty acid, fatty acid ester, vegetable oil, Solvents or stabilizers such as alcohols; Tocopherol derivatives, antioxidants such as L-ascorbic acid, dibutylhydroxytoluene and butylhydroxyanisole; preservatives such as p-hydroxybenzoate; Curling agents such as glycerin, propylene glycol and sodium hyaluronate; Surfactants such as polyoxyethylene derivatives, glycerol fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters and lecithin; Thickeners such as carboxyvinyl polymer, xanthan gum, carboxymethylcellulose and sodium carboxymethylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose; Stabilizers; Preservatives; Adsorption promoters; And other suitable fillers may be added.
In the case of the blowing agent, an adhesive such as a polyacrylic acid and a polyacrylic acid copolymer; A crosslinking agent such as aluminum sulfate, aluminum potassium sulfate, aluminum chloride, magnesium aluminometasilicate and dihydroxy aluminum aminoacetate; Thickening agents such as sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, gelatin, sodium alginate, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methylcellulose; Polyhydric alcohols such as glycerin, polyethylene glycol (macrogol), polyethylene glycol and 1,3-butanediol; Surfactants such as polyoxyethylene derivatives; fragrances such as l-menthol; preservatives such as p-hydroxybenzoate; Purified water; And other suitable fillers may be added.
In the case of a tape, a pressure-sensitive adhesive such as a styrene-isoprene-styrene block copolymer and an acrylate resin; Adhesive resins such as acrylic saturated hydrocarbon resins, hydrogenated rosin resins and terpene resins; Softeners such as liquid gums and liquid paraffin; Antioxidants such as dibutylhydroxytoluene; Polyhydric alcohols such as polyethylene glycol; Adsorption promoters such as oleic acid; Surfactants such as polyoxyethylene derivatives; And other suitable fillers may be added. In addition, water-absorbing polymers such as sodium polyacrylate and polyvinyl alcohol and a small amount of purified water can be added to the preparation of tapes containing water.
In the case of an aerosol agent, a base such as white petrolatum (Vaseline), yellow petrolatum, lanolin, purified beeswax, cetanol, stearyl alcohol, stearic acid, hydrogenated oil, hydrocarbon gel, polyethylene glycol, liquid paraffin and squalane; Oleic acid, isopropyl myristate, glycerol triisooctanoate, crotamitone, diethyl sebacate, diisopropyl sebacate, isopropyl adipate, hexyl laurate, fatty acid, fatty acid ester, vegetable oil, aliphatic alcohol and alcohol A solvent or a stabilizer such as; Tocopherol derivatives, antioxidants such as L-ascorbic acid, dibutylhydroxytoluene and butylhydroxyanisole; preservatives such as p-hydroxybenzoate; Curling agents such as glycerin, propylene glycol and sodium hyaluronate; Surfactants such as polyoxyethylene derivatives, glycerol fatty acid esters, sucrose fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters and lecithin, carboxyvinyl polymers such as those used in creams, gels or lotions, xanthan gum, carboxymethyl Thickeners such as cellulose and sodium carboxymethylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose; Stabilizers; Buffering agents; Sweetener suspension; Emulsifiers; Condiment; antiseptic; Adsorption promoters and other suitable fillers may be added.
For external powders, potato starch, rice starch, corn starch, fillers such as talc and zinc oxide, and other suitable additives may be added.
The external preparation for skin of the present invention may be prepared by mixing well-known ingredients with appropriate bases according to a well-known method for preparing external preparations, and the thus-prepared preparation is applied to lesions as required.
In another embodiment of the present invention, the present invention provides a skin whitening cosmetic composition containing an extract of Angelica gigas Nakai or a cosmetically acceptable carrier or additives thereof.
In another embodiment of the present invention, the cosmetic composition is characterized by having a whitening function.
In another embodiment of the present invention, the pharmaceutical composition is characterized by inhibiting the melanogenesis reaction.
In another embodiment of the present invention, the ginseng hot water extract in the cosmetic composition may be 0.000001 to 1 wt% of the total weight of the cosmetic composition.
In another embodiment of the present invention, the hot water extract of the cosmetic composition may be contained in an amount of 0.00001 to 0.01% by weight of the total cosmetic composition.
In another embodiment of the present invention, the ginseng hot water extract of the cosmetic composition may be contained in an amount of 0.00005 to 0.001 wt% of the total weight of the cosmetic composition.
The cosmetic composition of the present invention can be prepared in any formulations conventionally produced in the art and can be used in cosmetic formulations such as external ointments for skin, essence, whitening cream, lotion, emulsion, pack, general lotion, Serum, cosmetic soap, softening lotion, medicated lotion, hair tonic, whole body cleanser, oil gel and the like.
When the formulation of the present invention is a paste, a cream or a gel, an animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide .
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tragacanth.
When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters.
Hereinafter, the present invention will be described in more detail with reference to the following Experimental Examples and Preparation Examples. It should be understood, however, that the same is by way of illustration and example only and is not intended to limit the scope of the present invention.
Example One : figwort Manufacture of hot water extract
Two times the weight of hot water was added to the weight of fresh ginseng, the mixture was extracted for 12 hours, filtered and lyophilized to obtain an extract of hot water.
Example 2 : figwort Manufacture of hot water extract
Three times the weight of hot water was added to the weight of fresh ginseng, and the mixture was extracted for 12 hours, filtered and lyophilized to obtain an extract of hot water.
Example 3: figwort Manufacture of hot water extract
Four times the weight of hot water was added to the weight of fresh ginseng, the mixture was extracted for 12 hours, filtered, and lyophilized to obtain an extract of hot water.
Example 4 : figwort Manufacture of hot water extract
Five times the weight of hot water was added to the weight of the ginseng, the mixture was extracted for 12 hours, filtered and lyophilized to obtain an extract of hot water.
< Experimental Example >
B16-F10 A cytotoxicity experiment using melanoma cells was carried out using the EZ-cytox kit, and a tyrosinase inhibition assay was performed using the extract of Rhizoma grisea.
Experimental Example 1. Cytotoxicity ( Cell viability ) exam
Ez-cytox kit (Daeil Labservice, Seoul, Korea) was used to measure the effect of each natural product on cell proliferation rate. 2x10 < 4 > cells / ml of B16-F10 was cultured for 24 h in a 96-well plate. Thereafter, the culture medium was removed, the sample was diluted in the medium by concentration, and then pre-incubated for 24 hours at 37 ° C and 5% CO 2 in an incubator. And cultured at a concentration of 10 to 200 (μg / ml). After incubation for 1 hour with Ez-cytox kit solution, viable cells were identified by measuring absorbance at 450 nm with ELISA (BioTek, USA).
Experimental Example 2. Measurement of tyrosinase inhibitory activity in vitro Tyrosinase inhibition assay )
A tyrosinase inhibitory activity measuring method was carried out. In a 96-well plate, add 20 μL of each sample to 220 μL of 0.1 M phosphate buffer (pH 6.5), add 20 μL of mushroom tyrosinase (1500 U / mL), add 1.5 mM L-tyrosine (tyrosine) was added and reacted at 37 ° C for 15 minutes. DOPA chrome produced in the reaction solution was measured by ELISA (BioTek, USA) at a wavelength of 595 nm.
Claims (10)
The cosmetic composition for whitening skin according to claim 1, wherein the extract is in an amount of 0.000001 to 1% by weight based on the total weight of the cosmetic composition.
The cosmetic composition for whitening skin according to claim 1, wherein the extract of hot spring water is contained in an amount of 0.00001 to 0.01% by weight of the entire cosmetic composition.
The cosmetic composition for whitening skin according to claim 1, wherein the extract is in an amount of 0.00005 to 0.001% by weight based on the total weight of the cosmetic composition.
A cosmetic composition for skin whitening characterized in that the hot water extract of Hyacinthis inhibits the mechanism of melanin formation or suppresses melanogenesis.
The cosmetic composition for whitening skin according to claim 1, wherein the extract is in an amount of 0.000001 to 1% by weight based on the total weight of the cosmetic composition.
Wherein the extract of Angelica gigas Nakai is contained in an amount of 0.00001 to 0.01% by weight of the total cosmetic composition.
Wherein the extract is in an amount of 0.00005 to 0.001 wt% of the total weight of the cosmetic composition.
A pharmaceutical composition for skin whitening characterized in that the extract of hot spring water inhibits the mechanism of melanin formation or suppresses melanogenesis.
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| KR1020150048362A KR20160119548A (en) | 2015-04-06 | 2015-04-06 | Skin whitening composition comprising Scrophularia buergeriana hot water extract as an active ingredient |
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| KR1020150048362A KR20160119548A (en) | 2015-04-06 | 2015-04-06 | Skin whitening composition comprising Scrophularia buergeriana hot water extract as an active ingredient |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115487242A (en) * | 2022-11-17 | 2022-12-20 | 云南英格生物技术有限公司 | Radix scrophulariae extract and preparation method and application thereof |
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| KR100535266B1 (en) | 2003-02-18 | 2005-12-08 | 학교법인 한림대학교 | Scrophularia buergeriana extract with anti-aging activity and a composition containing the extract |
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| KR100890177B1 (en) | 2007-08-09 | 2009-03-25 | 광동제약 주식회사 | Composition comprising the combination of an extract of Scrophularia buergeriana and amino acid for treating or preventing the disease related to cognitive dysfunction |
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