CN106236687A - A kind of crease-resistant facial cream of chlorophyll and preparation method thereof - Google Patents
A kind of crease-resistant facial cream of chlorophyll and preparation method thereof Download PDFInfo
- Publication number
- CN106236687A CN106236687A CN201610735472.0A CN201610735472A CN106236687A CN 106236687 A CN106236687 A CN 106236687A CN 201610735472 A CN201610735472 A CN 201610735472A CN 106236687 A CN106236687 A CN 106236687A
- Authority
- CN
- China
- Prior art keywords
- extracting solution
- parts
- chlorophyll
- herba
- crease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- A61Q19/08—Anti-ageing preparations
Abstract
The open a kind of crease-resistant facial cream of chlorophyll of the present invention, including following raw material: cyanophyceae chlorophyll, antibacterial peptide, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution part, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution, Vegetable oil lipoprotein, preservative, emulsifying agent, supercritical propolis, Lac regis apis, deionized water.Invention additionally discloses a kind of method preparing the crease-resistant facial cream of above-mentioned chlorophyll.The present invention has good penetrability, easily absorption, crease-resistant composition effectively sends to skin deep layer, repair wrinkle of skin, suppression wrinkle regenerates, the advantage of delay skin aging.
Description
Technical field
The present invention relates to cosmetology technical field, particularly relate to a kind of crease-resistant facial cream of chlorophyll and preparation method thereof.
Background technology
Wrinkle refers to that skin is affected by external environment, forms free free radical, and free radical destroys normal cell membrane tissue
In collagen protein, active substance, oxidative cell and formed little microgroove, wrinkle.Wrinkle occurs gradually.The order occurred is general
It it is forehead, upper palpebra inferior, paropia, ear proparea, cheek, cervical region, lower chin, mouth week.Facial wrinkles is divided into atrophy wrinkle and loose wrinkle
Stricture of vagina two types.Atrophy wrinkle refers to occur in the wrinkle on jackknifing thin, easy and dry skin, and such as circumference of eyes, those are countless
Tiny wrinkle；Loose wrinkle refers to the wrinkle occurring in oily skin, and quantity is few, and texture is close and deep, such as forehead, lip.
Common wrinkle removal, anti-wrinkle method are nothing more than plastic operation, injection wrinkle removal, the several big class of skin cosmetic.
Operation smoothing wrinkle, for the lax Rhytidectomy of skin of face large area, the smoothing wrinkle of deep part, is a kind of long-acting
Wrinkle removal method, still its applicable middle-aged and elderly people selects to use, but there is certain risk.
Injection smoothing wrinkle, injection smoothing wrinkle pin beauty treatment, the space between support, tytosis interstitial can be played, it is impossible to enter
To cell interior generate competent cell source, can 6～12 months by body metabolism out.Multiple injection, is difficult to maintain.For reaching
Effect, smoothing wrinkle pin needs to be repeated several times injection, on the one hand brings risk to beautifying and antisenility, the also misery of per injection, fund
A large amount of inputs, if duplicate injection can cause skin to anchylose because of long-term accumulated.
Carry out crease-resistant by skin cosmetic, there is simple, direct, effective advantage.But city is high at present.Along with life
The raising that running water is flat, people's requirement diversified for cosmetics is more and more higher, more and more higher to the quality requirements of cosmetics,
Need to provide the new product of more high-quality.
Summary of the invention
The present invention is directed to the problem that prior art exists, it is provided that a kind of good penetrability, easily absorption, crease-resistant composition are effectively sent
Reach skin deep layer, repair wrinkle of skin, suppression wrinkle regeneration, the crease-resistant facial cream of chlorophyll of delay skin aging and preparation side thereof
Method.
The present invention mainly realizes above-mentioned technique effect by techniques below means: a kind of crease-resistant facial cream of chlorophyll, including
The raw material of following mass fraction: cyanophyceae chlorophyll 0.12～0.56 part, antibacterial peptide 0.03～0.85 part, Radix Ginseng extractive solution 0.08～
0.23 part, Herba Dendrobii extracting solution 0.12～0.25 part, Fructus Mali pumilae extracting solution 0.12～0.31 part, Herba Menthae extracting solution 0.16～0.34
Part, Herba Centellae extracting solution 0.11～0.22 part, Flos Rosae Chinensis extracting solution 0.14～0.39 part, olive oil 2.1～3.5 parts, wheat germ
Bud oil 2.2～2.8 parts, hickory oil 1.5～2.3 parts, Oleum camelliae 3.1～3.9 parts, Radix Glycyrrhizae extract 0.24～0.33 part,
Flos Caryophylli extracting solution 0.18～0.26 part, butanediol 2.3～4.2 parts, glycerol 2.3～2.7 parts, glyceryl monostearate 2.1～3.8
Part, isopropyl myristate 2.5～3.6 parts, dicaprylyl carbonate 2.3～3.5 parts, supercritical propolis 0.8～0.94 part, Lac regis apis
0.77～1.02 part, deionized water 71.5～89.6 parts.
Preferably, cyanophyceae chlorophyll 0.44 part, antibacterial peptide 0.68 part, Radix Ginseng extractive solution 0.21 part, Herba Dendrobii extracting solution
0.23 part, Fructus Mali pumilae extracting solution 0.28 part, Herba Menthae extracting solution 0.31 part, Herba Centellae extracting solution 0.21 part, Flos Rosae Chinensis extracting solution 0.35
Part, 3.2 parts of olive oil, Semen Tritici aestivi germ oil 2.6 parts, hickory oil 2.2 parts, Oleum camelliae 3.4 parts, Radix Glycyrrhizae extract 0.31 part,
Flos Caryophylli extracting solution 0.23 part, butanediol 3.2 parts, glycerol 2.5 parts, glyceryl monostearate 2.6 parts, isopropyl myristate 3.1
Part, dicaprylyl carbonate 3.2 parts, supercritical propolis 0.92 part, Lac regis apis 0.98 part, deionized water 86.2 parts.
Preferably, cyanophyceae chlorophyll 0.32 part, antibacterial peptide 0.45 part, Radix Ginseng extractive solution 0.12 part, Herba Dendrobii extracting solution
0.17 part, Fructus Mali pumilae extracting solution 0.23 part, Herba Menthae extracting solution 0.23 part, Herba Centellae extracting solution 0.17 part, Flos Rosae Chinensis extracting solution 0.25
Part, 2.5 parts of olive oil, Semen Tritici aestivi germ oil 2.6 parts, hickory oil 2.1 parts, Oleum camelliae 3.3 parts, Radix Glycyrrhizae extract 0.25 part,
Flos Caryophylli extracting solution 0.21 part, butanediol 4.1 parts, glycerol 2.6 parts, glyceryl monostearate 3.5 parts, isopropyl myristate 3.5
Part, dicaprylyl carbonate 3.2 parts, supercritical propolis 0.89 part, Lac regis apis 0.92 part, deionized water 80.2 parts.
Preferably, cyanophyceae chlorophyll 0.35 part, antibacterial peptide 0.36 part, Radix Ginseng extractive solution 0.19 part, Herba Dendrobii extracting solution
0.21 part, Fructus Mali pumilae extracting solution 0.26 part, Herba Menthae extracting solution 0.31 part, Herba Centellae extracting solution 0.18 part, Flos Rosae Chinensis extracting solution 0.22
Part, 3.1 parts of olive oil, Semen Tritici aestivi germ oil 2.5 parts, hickory oil 1.9 parts, Oleum camelliae 3.4 parts, Radix Glycyrrhizae extract 0.31 part,
Flos Caryophylli extracting solution 0.22 part, butanediol 2.8 parts, glycerol 2.5 parts, glyceryl monostearate 2.4 parts, isopropyl myristate 2.7
Part, dicaprylyl carbonate 2.9 parts, supercritical propolis 0.89 part, Lac regis apis 0.93 part, deionized water 87.2 parts.
Invention additionally discloses a kind of method preparing the crease-resistant facial cream of above-mentioned chlorophyll, comprise the following steps:
(1) carry out grinding process by cyanophyceae, water-soluble by the ethanol of the feed liquid mass ratio addition 60～80%wt of 1:15～32
Liquid, carries out ultrasonic-leaching 10～18min under conditions of 23～36KHz, 32～41w, after being filtered by lixiviating solution, 60～85
Carry out vacuum distilling concentration at DEG C, obtain chlorophyll extractum；It is that chlorophyll extractum is added extremely by 1:2～5 according to mass volume ratio
In the 92%wt ethanol water of 4%wtNaOH, saponification 1～2h at 50～68 DEG C, then the concentration of ethanol is adjusted to 78%,
PH value 6.8, adds saponification liquor quality 3～the zinc acetate of 4%, is cooled to 40～45 DEG C, stirs 0.5～1h, obtains cyanophyceae leaf green
Element；
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, myristic acid isopropyl
Ester, dicaprylyl carbonate are placed in oil phase pot, heating, after stirring and dissolving, are incubated standby；
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, add
Heat is to dissolving completely, in the emulsifying pot that then suction is warmed-up, and stirring, then by the material suction emulsifying pot of step (2),
Homogenizing；
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae
Extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
Preferably, in described step (1), when ultrasonic-leaching, add the cellulase of 0.02～0.04%wt.
Preferably, the Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae are extracted
Liquid, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Huoshan
Herba Dendrobii, Fructus Mali pumilae, Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli shred, and are separately added into according still further to mass volume ratio 1:12～18
Water is hotted plate, after boiling, continues to boil 2～3h, filter, collect extracting solution.
Preferably, the Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae are extracted
Liquid, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are before preparation, respectively to Radix Ginseng, Huoshan stone
Dry measure used in former times, Fructus Mali pumilae, Herba Menthae, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli carry out sterilization processing；The technique of sterilization: each plant after Xi Jinging, water
Fruit is respectively placed in boiling water sterilization 3～5min, takes out and is placed in water cooling.
Preferably, the heating-up temperature of described step (2) is 80～85 DEG C；Step (3) heating-up temperature is 85～90 DEG C, homogenizing
Time is 5～10min；Step (4) be cooled to 60～55 DEG C, mixing time be 3～7min；Step (5) be cooled to 45～40 DEG C,
Mixing time 3～7min, is cooled to room temperature.
Preferably, described filtering technique: 100 mesh nylon filtering cloths are soaked, it is folded into 2 layers of funnel being laid in vacuum filtration
In, edge is placed in outside funnel, opens vacuum filtration machine, and vacuum is more than 0.07MPa, then is poured into leakage by each liquid to be filtered respectively
In bucket, filter.
In recent years, due to the pollution of environment, causing the eutrophication of water environment, the phenomenon that cyanophyceae is spread unchecked is risen one after another.This
Chlorophyll in invention has drawn from cyanophyceae, on the one hand utilizes chlorophyll to carry out antioxidation, promote metabolism and skin repair ability, has
Help and dispel pox print；On the other hand, due to the cyanophyceae that has drawn from, the problem solving water environment pollution to a certain extent.
Herba Dendrobii extracting solution in the present invention is rich in polysaccharide, dendrobine, free amino acid, vitamin (vitamin A, dimension
Raw element C, vitamin E), chlorophyll and various enzyme, there is hemostasis, promote wound healing, effect of reparation damaged skin.
Radix Ginseng extractive solution in the present invention contains ginsenoside, panaxatriol, several mineral materials and vitamin, has promotion
The blood circulation of subcutaneous capillary, the nutrition supply etc. increasing skin acts on, moreover it is possible to the balance of regulation of skin moisture, prevents skin
Skin drying and dehydrating, increases the elasticity of skin, play keep skin bright and clean tender, prevent or reduce the effect of wrinkle of skin.
The Fructus Mali pumilae extracting solution of the present invention can activate the stem cell of skin base layer, allows Skin Cell regenerate, and postpones wrinkle
Appearance；It also has oxidation resistance, the ripe aging process of the skin that effectively slows down, and also can improve the dim heavy and wrinkle of skin
Stricture of vagina, gives skin lock outlet capacity.
The Flos Rosae Chinensis extracting solution of the present invention has whitening convergence granulation promoting, promotes cell regeneration and effect of cicatrix healing, is beautiful
The treasure of white skin protection.
Dicaprylyl carbonate in the present invention is a kind of emollient, and it has the dryest and the comfortableest skinfeel and good spreadability,
Can compare favourably with volatile silicone oils；Meanwhile, it has fine dissolubility to crystal type Orangic sunscreen and titanium dioxide, zinc oxide,
It is used in sunscreen product the spf value being remarkably improved product the greasy feeling lowering sunscreen.
Isopropyl myristate in the present invention can play the effect of moisturizing and skin care, can be in cortex and hair follicle
Effectively contact, penetrates into cortex depths, and the active component in cosmetics is brought into, give full play to the effect of effective ingredient.
Present invention monoglyceride as emulsifying agent, preferably glyceryl monostearate, it is also possible to be glycerol distearate.
The Herba Centellae extracting solution energy aging resistance of the present invention, consolidation pore, effect except microgroove, be also the anti-ageing sage of beauty treatment
Product.There is effect that skin lightening of invigorating blood circulation, whitening are wrinkle resistant.
The present invention uses the extracting solution (Radix Glycyrrhizae extract, Flos Caryophylli extracting solution) of natural plants, antibacterial peptide to mix as antibacterial
Preservative, does not contains any chemosynthesis material, has no side effect.
Radix Glycyrrhizae contains the Radix Glycyrrhizae acid amide of nearly 12%, has good antiinflammatory to releive composition, has the work of antiinflammatory, antiallergic action
With, and can neutralize or release the noxious substance of skin, licoflavone can also suppress tyrosinase activity, eliminate free radical, to skin
Skin has moisture-keeping function.Flos Caryophylli has removal small pox, desalination pox print, effect of balance skin to skin.Antibacterial peptide is a kind of tool
There is bioactive micromolecule polypeptide, there is broad spectrum antibiotic activity, antibacterial is had the strongest lethal effect, especially can kill certain
A little drug resistance pathogen.
Butanediol, glycerol Main Function in the present invention be: efficient moisture-retention agent, moistens, and strengthens nano-encapsulated propolis etc. and lives
Property composition emulsifying dispersivity and promote infiltration with absorb.
The present invention use crude vegetal (olive oil, Semen Tritici aestivi germ oil, hickory oil, wild camellia oil content) as oils and fats,
Environmental protection, has good permeability, lubricity and safety.Meanwhile, crude vegetal makes chlorophyll preferably be dissolved in
In system, strengthen sun-proof result.
Supercritical propolis in the present invention, Lac regis apis preferably employ supercritical extraction unit and nanometer emulsified machine extracts and system
Standby, it is also possible to be existing supercritical propolis, Lac regis apis.Have strength antioxidation, activating cell, moisturizing, offer nutrient,
Repair effect of environmental damage.
The present invention is by by multiple Chinese herbal medicine, crude vegetal, natural plant preservative, efficient moisture-retention agent, emulsifying agent, indigo plant
The raw material mixing such as algae chlorophyll, royal jelly, Lac regis apis, utilize effect of each raw material, complement each other, and joining according to the present invention
Effectively send to skin deep layer than having property of the facial cream absorption good, easy of preparation, crease-resistant composition, repair wrinkle of skin, suppression wrinkle
Stricture of vagina regeneration, the technique effect of delay skin aging.
Detailed description of the invention
Embodiment 1
The open a kind of crease-resistant facial cream of chlorophyll of the present embodiment, including the raw material of following mass fraction: cyanophyceae chlorophyll 0.12
Part, antibacterial peptide 0.03 part, Radix Ginseng extractive solution 0.08 part, Herba Dendrobii extracting solution 0.12 part, Fructus Mali pumilae extracting solution 0.12 part, Herba Menthae carry
Take liquid 0.16 part, Herba Centellae extracting solution 0.11 part, Flos Rosae Chinensis extracting solution 0.14 part, 2.1 parts of olive oil, Semen Tritici aestivi germ oil 2.2 parts,
Hickory oil 1.5 parts, Oleum camelliae 3.1 parts, Radix Glycyrrhizae extract 0.24 part, Flos Caryophylli extracting solution 0.18 part, butanediol 2.3 parts, sweet
Oil 2.3 parts, glyceryl monostearate 2.1 parts, isopropyl myristate 2.5 parts, dicaprylyl carbonate 2.3 parts, supercritical propolis 0.8
Part, Lac regis apis 0.77 part, deionized water 71.5 parts.
The preparation method of the present embodiment, comprises the following steps:
(1) carry out grinding process by cyanophyceae, add the ethanol water of 60%wt by the feed liquid mass ratio of 1:15,
Carry out ultrasonic-leaching 10min under conditions of 23KHz, 32w, after being filtered by lixiviating solution, at 60 DEG C, carry out vacuum distilling concentration,
Obtain chlorophyll extractum；It is that chlorophyll extractum is added the 92%wt ethanol water to 4%NaOH by 1:2 according to mass volume ratio
In, saponification 1h at 50 DEG C, then the concentration of ethanol is adjusted to 78%, pH value 6.8, add the zinc acetate of saponification liquor quality 3%,
It is cooled to 40 DEG C, stirs 0.5h, obtain cyanophyceae chlorophyll.
Using cyanophyceae chlorophyll prepared by the method for the present invention, it had both remained chlorophyllous effect, had added product
Added value.By filling into zinc, develop chlorophyll zinc, the advantage with green in color, pure color, light, Heat stability is good.
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, myristic acid isopropyl
Ester, dicaprylyl carbonate are placed in oil phase pot, heating, after stirring and dissolving, are incubated standby.
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, add
Heat, to dissolving completely, in the emulsifying pot that then suction is warmed-up, opens stirring, then by the material suction emulsifying of step (2)
In Guo, homogenizing.
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae
Extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae,
Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli shred, and are added to the water according to mass volume ratio 1:12 respectively and hot plate, wait to boil
After, continue to boil 2h, filter, collect extracting solution.
The preparation method of extracting solution of the present invention, simple to operate, extraction effect good, pollution-free.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are before preparation, respectively to Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, thin
Lotus, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli carry out sterilization processing；The technique of sterilization: each plant after Xi Jinging, fruit are respectively placed in
Sterilize in boiling water 3min, takes out and is placed in water cooling.
By sterilization processing, on the one hand purify the impurity on thing surface to be extracted, carry out pretreatment, it is simple to later process adds
Work；On the other hand, eliminate harmful antibacterial, prevent allergy.
The heating-up temperature of described step (2) is 80 DEG C；Step (3) heating-up temperature is 85 DEG C, homogenizing 5min；Step (4) drops
Warm to 60 DEG C, stirring 3min；Step (5) is cooled to 45 DEG C, stirring 3min, is cooled to room temperature.By optimizing preparation parameter, improve
Work efficiency and purity, yield.
Described filtering technique: soaked by 100 mesh nylon filtering cloths, is folded in 2 layers of funnel being laid in vacuum filtration, edge
Being placed in outside funnel, open vacuum filtration machine, vacuum is more than 0.07MPa, then pours in funnel by each liquid to be filtered respectively, mistake
Filter.The filter method of the present invention is simple, filter efficiency is high.
Embodiment 2
The open a kind of crease-resistant facial cream of chlorophyll of the present embodiment, including the raw material of following mass fraction: cyanophyceae chlorophyll 0.56
Part, antibacterial peptide 0.85 part, Radix Ginseng extractive solution 0.23 part, Herba Dendrobii extracting solution 0.25 part, Fructus Mali pumilae extracting solution 0.31 part, Herba Menthae carry
Take liquid 0.34 part, Herba Centellae extracting solution 0.22 part, Flos Rosae Chinensis extracting solution 0.39 part, 3.5 parts of olive oil, Semen Tritici aestivi germ oil 2.8 parts,
Hickory oil 2.3 parts, Oleum camelliae 3.9 parts, Radix Glycyrrhizae extract 0.33 part, Flos Caryophylli extracting solution 0.26 part, butanediol 4.2 parts, sweet
Oil 2.7 parts, glyceryl monostearate 3.8 parts, isopropyl myristate 3.6 parts, dicaprylyl carbonate 3.5 parts, supercritical propolis
0.94 part, Lac regis apis 1.02 parts, deionized water 89.6 parts.
The preparation method of the present embodiment, comprises the following steps:
(1) carry out grinding process by cyanophyceae, add the ethanol water of 80%wt by the feed liquid mass ratio of 1:32,
Carry out ultrasonic-leaching 18min under conditions of 36KHz, 41w, after being filtered by lixiviating solution, at 85 DEG C, carry out vacuum distilling concentration,
Obtain chlorophyll extractum；It is that chlorophyll extractum is added the 92%wt ethanol water to 4%NaOH by 1:5 according to mass volume ratio
In, saponification 2h at 68 DEG C, then the concentration of ethanol is adjusted to 78%, pH value 6.8, add the zinc acetate of saponification liquor quality 4%,
It is cooled to 45 DEG C, stirs 1h, obtain cyanophyceae chlorophyll.
When ultrasonic-leaching, add the cellulase of 0.02%wt, improve cell disintegration effect, accelerate chlorophyllous system
Standby.
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, myristic acid isopropyl
Ester, dicaprylyl carbonate are placed in oil phase pot, heating, after stirring and dissolving, are incubated standby.
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, add
Heat, to dissolving completely, in the emulsifying pot that then suction is warmed-up, opens stirring, then by the material suction emulsifying of step (2)
In Guo, homogenizing.
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae
Extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae,
Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli shred, and are added to the water according to mass volume ratio 1:18 respectively and hot plate, wait to boil
After, continue to boil 3h, filter, collect extracting solution.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are before preparation, respectively to Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, thin
Lotus, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli carry out sterilization processing；The technique of sterilization: each plant after Xi Jinging, fruit are respectively placed in
Sterilize in boiling water 5min, takes out and is placed in water cooling.
By sterilization processing, on the one hand purify the impurity on thing surface to be extracted, carry out pretreatment, it is simple to later process adds
Work；On the other hand, eliminate harmful antibacterial, prevent allergy.
The heating-up temperature of described step (2) is 85 DEG C；Step (3) heating-up temperature is 90 DEG C, homogenizing 10min；Step (4) drops
Warm to 55 DEG C, stirring 7min；Step (5) is cooled to 40 DEG C, stirring 7min, is cooled to room temperature.By optimizing preparation parameter, improve
Work efficiency and purity, yield.
Described filtering technique: soaked by 100 mesh nylon filtering cloths, is folded in 2 layers of funnel being laid in vacuum filtration, edge
Being placed in outside funnel, open vacuum filtration machine, vacuum is more than 0.07MPa, then pours in funnel by each liquid to be filtered respectively, mistake
Filter.The filter method of the present invention is simple, filter efficiency is high.
Embodiment 3
The open a kind of crease-resistant facial cream of chlorophyll of the present embodiment, including the raw material of following mass fraction: cyanophyceae chlorophyll 0.44
Part, antibacterial peptide 0.68 part, Radix Ginseng extractive solution 0.21 part, Herba Dendrobii extracting solution 0.23 part, Fructus Mali pumilae extracting solution 0.28 part, Herba Menthae carry
Take liquid 0.31 part, Herba Centellae extracting solution 0.21 part, Flos Rosae Chinensis extracting solution 0.35 part, 3.2 parts of olive oil, Semen Tritici aestivi germ oil 2.6 parts,
Hickory oil 2.2 parts, Oleum camelliae 3.4 parts, Radix Glycyrrhizae extract 0.31 part, Flos Caryophylli extracting solution 0.23 part, butanediol 3.2 parts, sweet
Oil 2.5 parts, glyceryl monostearate 2.6 parts, isopropyl myristate 3.1 parts, dicaprylyl carbonate 3.2 parts, supercritical propolis
0.92 part, Lac regis apis 0.98 part, deionized water 86.2 parts.
The preparation method of the present embodiment comprises the following steps:
(1) carry out grinding process by cyanophyceae, add the ethanol water of 75%wt by the feed liquid mass ratio of 1:20,
Carry out ultrasonic-leaching 15min under conditions of 28KHz, 37w, after being filtered by lixiviating solution, at 67 DEG C, carry out vacuum distilling concentration,
Obtain chlorophyll extractum；It is that chlorophyll extractum is added the 92%wt ethanol water to 4%NaOH by 1:4 according to mass volume ratio
In, saponification 1.5h at 58 DEG C, then the concentration of ethanol is adjusted to 78%, pH value 6.8, add the second of saponification liquor quality 3.5%
Acid zinc, is cooled to 44 DEG C, stirs 0.8h, obtains cyanophyceae chlorophyll.
Using cyanophyceae chlorophyll prepared by the method for the present invention, it had both remained chlorophyllous effect, had added product
Added value.By filling into zinc, develop chlorophyll zinc, the advantage with green in color, pure color, light, Heat stability is good.
Some embodiment, when ultrasonic-leaching, adds the cellulase of 0.03%wt, improves cell disintegration effect, add
The chlorophyllous preparation of speed.
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, myristic acid isopropyl
Ester, dicaprylyl carbonate are placed in oil phase pot, heating, after stirring and dissolving, are incubated standby.
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, add
Heat, to dissolving completely, in the emulsifying pot that then suction is warmed-up, opens stirring, then by the material suction emulsifying of step (2)
In Guo, homogenizing.
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae
Extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae,
Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli shred, and are added to the water according to mass volume ratio 1:15 respectively and hot plate, wait to boil
After, continue to boil 2.5h, filter, collect extracting solution.
The preparation method of extracting solution of the present invention, simple to operate, extraction effect good, pollution-free.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are before preparation, respectively to Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, thin
Lotus, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli carry out sterilization processing；The technique of sterilization: each plant after Xi Jinging, fruit are respectively placed in
Sterilize in boiling water 4min, takes out and is placed in water cooling.
By sterilization processing, on the one hand purify the impurity on thing surface to be extracted, carry out pretreatment, it is simple to later process adds
Work；On the other hand, eliminate harmful antibacterial, prevent allergy.
The heating-up temperature of described step (2) is 83 DEG C；Step (3) heating-up temperature is 83 DEG C, homogenizing 7min；Step (4) drops
Warm to 58 DEG C, stirring 6min；Step (5) is cooled to 43 DEG C, stirring 5min, is cooled to room temperature.By optimizing preparation parameter, improve
Work efficiency and purity, yield.
Described filtering technique: soaked by 100 mesh nylon filtering cloths, is folded in 2 layers of funnel being laid in vacuum filtration, edge
Being placed in outside funnel, open vacuum filtration machine, vacuum is more than 0.07MPa, then pours in funnel by each liquid to be filtered respectively, mistake
Filter.The filter method of the present invention is simple, filter efficiency is high.
Embodiment 4
The open a kind of crease-resistant facial cream of chlorophyll of the present embodiment, including the raw material of following mass fraction: cyanophyceae chlorophyll 0.32
Part, antibacterial peptide 0.45 part, Radix Ginseng extractive solution 0.12 part, Herba Dendrobii extracting solution 0.17 part, Fructus Mali pumilae extracting solution 0.23 part, Herba Menthae carry
Take liquid 0.23 part, Herba Centellae extracting solution 0.17 part, Flos Rosae Chinensis extracting solution 0.25 part, 2.5 parts of olive oil, Semen Tritici aestivi germ oil 2.6 parts,
Hickory oil 2.1 parts, Oleum camelliae 3.3 parts, Radix Glycyrrhizae extract 0.25 part, Flos Caryophylli extracting solution 0.21 part, butanediol 4.1 parts, sweet
Oil 2.6 parts, glyceryl monostearate 3.5 parts, isopropyl myristate 3.5 parts, dicaprylyl carbonate 3.2 parts, supercritical propolis
0.89 part, Lac regis apis 0.92 part, deionized water 80.2 parts.
The preparation method of the present embodiment comprises the following steps:
(1) carry out grinding process by cyanophyceae, add the ethanol water of 75%wt by the feed liquid mass ratio of 1:20,
Carry out ultrasonic-leaching 15min under conditions of 28KHz, 37w, after being filtered by lixiviating solution, at 67 DEG C, carry out vacuum distilling concentration,
Obtain chlorophyll extractum；It is that chlorophyll extractum is added the 92%wt ethanol water to 4%NaOH by 1:4 according to mass volume ratio
In, saponification 1.5h at 58 DEG C, then the concentration of ethanol is adjusted to 78%, pH value 6.8, add the second of saponification liquor quality 3.5%
Acid zinc, is cooled to 44 DEG C, stirs 0.8h, obtains cyanophyceae chlorophyll.
Using cyanophyceae chlorophyll prepared by the method for the present invention, it had both remained chlorophyllous effect, had added product
Added value.By filling into zinc, develop chlorophyll zinc, the advantage with green in color, pure color, light, Heat stability is good.
Some embodiment, when ultrasonic-leaching, adds the cellulase of 0.04%wt, improves cell disintegration effect, add
The chlorophyllous preparation of speed.
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, myristic acid isopropyl
Ester, dicaprylyl carbonate are placed in oil phase pot, heating, after stirring and dissolving, are incubated standby.
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, add
Heat, to dissolving completely, in the emulsifying pot that then suction is warmed-up, opens stirring, then by the material suction emulsifying of step (2)
In Guo, homogenizing.
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae
Extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae,
Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli shred, and are added to the water according to mass volume ratio 1:15 respectively and hot plate, wait to boil
After, continue to boil 2.5h, filter, collect extracting solution.
The preparation method of extracting solution of the present invention, simple to operate, extraction effect good, pollution-free.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are before preparation, respectively to Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, thin
Lotus, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli carry out sterilization processing；The technique of sterilization: each plant after Xi Jinging, fruit are respectively placed in
Sterilize in boiling water 4min, takes out and is placed in water cooling.
By sterilization processing, on the one hand purify the impurity on thing surface to be extracted, carry out pretreatment, it is simple to later process adds
Work；On the other hand, eliminate harmful antibacterial, prevent allergy.
The heating-up temperature of described step (2) is 83 DEG C；Step (3) heating-up temperature is 83 DEG C, homogenizing 7min；Step (4) drops
Warm to 58 DEG C, stirring 6min；Step (5) is cooled to 43 DEG C, stirring 5min, is cooled to room temperature.By optimizing preparation parameter, improve
Work efficiency and purity, yield.
Described filtering technique: soaked by 100 mesh nylon filtering cloths, is folded in 2 layers of funnel being laid in vacuum filtration, edge
Being placed in outside funnel, open vacuum filtration machine, vacuum is more than 0.07MPa, then pours in funnel by each liquid to be filtered respectively, mistake
Filter.The filter method of the present invention is simple, filter efficiency is high.
Embodiment 5
The open a kind of crease-resistant facial cream of chlorophyll of the present embodiment, including the raw material of following mass fraction: cyanophyceae chlorophyll 0.35
Part, antibacterial peptide 0.36 part, Radix Ginseng extractive solution 0.19 part, Herba Dendrobii extracting solution 0.21 part, Fructus Mali pumilae extracting solution 0.26 part, Herba Menthae carry
Take liquid 0.31 part, Herba Centellae extracting solution 0.18 part, Flos Rosae Chinensis extracting solution 0.22 part, 3.1 parts of olive oil, Semen Tritici aestivi germ oil 2.5 parts,
Hickory oil 1.9 parts, Oleum camelliae 3.4 parts, Radix Glycyrrhizae extract 0.31 part, Flos Caryophylli extracting solution 0.22 part, butanediol 2.8 parts, sweet
Oil 2.5 parts, glyceryl monostearate 2.4 parts, isopropyl myristate 2.7 parts, dicaprylyl carbonate 2.9 parts, supercritical propolis
0.89 part, Lac regis apis 0.93 part, deionized water 87.2 parts.
The preparation method of the present embodiment comprises the following steps:
(1) carry out grinding process by cyanophyceae, add the ethanol water of 75%wt by the feed liquid mass ratio of 1:20,
Carry out ultrasonic-leaching 15min under conditions of 28KHz, 37w, after being filtered by lixiviating solution, at 67 DEG C, carry out vacuum distilling concentration,
Obtain chlorophyll extractum；It is that chlorophyll extractum is added the 92%wt ethanol water to 4%NaOH by 1:4 according to mass volume ratio
In, saponification 1.5h at 58 DEG C, then the concentration of ethanol is adjusted to 78%, pH value 6.8, add the second of saponification liquor quality 3.5%
Acid zinc, is cooled to 44 DEG C, stirs 0.8h, obtains cyanophyceae chlorophyll.
Using cyanophyceae chlorophyll prepared by the method for the present invention, it had both remained chlorophyllous effect, had added product
Added value.By filling into zinc, develop chlorophyll zinc, the advantage with green in color, pure color, light, Heat stability is good.
When ultrasonic-leaching, add the cellulase of 0.03%wt, improve cell disintegration effect, accelerate chlorophyllous system
Standby.
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, myristic acid isopropyl
Ester, dicaprylyl carbonate are placed in oil phase pot, heating, after stirring and dissolving, are incubated standby.
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, add
Heat, to dissolving completely, in the emulsifying pot that then suction is warmed-up, opens stirring, then by the material suction emulsifying of step (2)
In Guo, homogenizing.
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae
Extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae,
Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli shred, and are added to the water according to mass volume ratio 1:15 respectively and hot plate, wait to boil
After, continue to boil 2.5h, filter, collect extracting solution.
The preparation method of extracting solution of the present invention, simple to operate, extraction effect good, pollution-free.
Radix Ginseng extractive solution in described step (5), Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae
Extracting solution, Flos Rosae Chinensis extracting solution, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are before preparation, respectively to Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, thin
Lotus, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae, Flos Caryophylli carry out sterilization processing；The technique of sterilization: each plant after Xi Jinging, fruit are respectively placed in
Sterilize in boiling water 4min, takes out and is placed in water cooling.
By sterilization processing, on the one hand purify the impurity on thing surface to be extracted, carry out pretreatment, it is simple to later process adds
Work；On the other hand, eliminate harmful antibacterial, prevent allergy.
The heating-up temperature of described step (2) is 83 DEG C；Step (3) heating-up temperature is 83 DEG C, homogenizing 7min；Step (4) drops
Warm to 58 DEG C, stirring 6min；Step (5) is cooled to 43 DEG C, stirring 5min, is cooled to room temperature.By optimizing preparation parameter, improve
Work efficiency and purity, yield.
Described filtering technique: soaked by 100 mesh nylon filtering cloths, is folded in 2 layers of funnel being laid in vacuum filtration, edge
Being placed in outside funnel, open vacuum filtration machine, vacuum is more than 0.07MPa, then pours in funnel by each liquid to be filtered respectively, mistake
Filter.The filter method of the present invention is simple, filter efficiency is high.
Embodiment 6 (comparative example 1)
The present embodiment discloses a kind of crease-resistant facial cream, including the raw material of following mass fraction: 2.5 parts of olive oil, Fructus Tritici aestivi
Oil 2.4 parts, hickory oil 2 parts, Oleum camelliae 3.5 parts, Radix Glycyrrhizae extract 3.1 parts, Flos Caryophylli extracting solution 0.24 part, monostearate are sweet
Grease 2.4 parts, butanediol 3.1 parts, glycerol 2.4 parts, deionized water 85 parts.
Preparation method:
(1) olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae are placed in oil phase pot, are heated to 85 DEG C, stirring
After dissolving, it is incubated standby.
(2) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution are added in aqueous phase pot, be heated to 85
DEG C dissolve completely, in the emulsifying pot that then suction is warmed-up, open stirring, then by the material suction emulsifying pot of step (1)
In, homogenizing, cooling discharging, obtain product.
Embodiment 7 (comparative example 2)
The crease-resistant facial cream of collagen protein disclosed in Application No. 201410698376.4.
Embodiment 8
Toxicity test of the present invention
1. test material: animal: white mice, body weight 22～27g, male and female half and half.Medicine: the embodiment of the present invention 2 crease-resistant
Facial cream.
2, experimental technique: take white mice 30, each 15 of male and female.The crease-resistant facial cream of the embodiment of the present invention 2 is added distilled water
Dissolve (every ml 0.36g Han crude drug), by the maximum tolerated dose of animal, can twitch with injection filling hello device and be as the criterion.In animal fasting (no
Prohibit water) after 20h, it is administered (interval 1h), each 0.5ml in one day at twice, total dose is 18g crude drug/kg.d, quite clinical one-tenth
300 times of people's 50kg body weight consumption.Continuous Observation 7 days after administration.
In 7 day observation period, the appetite of white mice, activity, hair color, the mental status etc. are all normal, grow normal, there are no
Dead.I.e. select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that toxicity is little, MTD ＞ 18g/
kg.d。
Embodiment 9
Human body skin patch is tested
1. test material: tested crowd's number: 100 people, sex: women, the age: 30～60 years old, the embodiment of the present invention 1 or
The crease-resistant facial cream of 3.
2. experimental technique: with closed patch experiment method, drips in speckle examination device, outward by tested material 0.02g～0.025g
Be covered on experimenter back with special adhesive tape, after 24h remove tested material, respectively remove after 1,6,12,24,48h observe skin anti-
Should, record its result result according to dermoreaction grade scale in " cosmetics health specification ".
3. experimental result: human skin patch result shows: each group experimenter patch test by crease-resistant facial cream,
1,6,12,24,48h observe dermoreaction, wherein there is skin adverse reaction in 0 example, and the crease-resistant facial cream described in explanation uses peace
Entirely.
Embodiment 10
Anti-wrinkle effect is tested
1. test material: tested crowd's number: 150 people, sex: women, the age: 30～60 years old, the embodiment of the present invention 4,
Comparative example 1, the crease-resistant facial cream of comparative example 2.
2. experimental technique:
Using skin elasticity CotometerMPA580 main frame, probe is Reviscometer RV600 elastic fibrous tissue
Test probe, surveys and averages for five times.Test zone: up 2cm forehead region, place between the eyebrows middle, lower lip middle are down
Left and right cheek region at 2cm chin area, nose and pupil intersection.First measure the blank value of 30min after tested region clean
(R2, R5, R7), then regulation experimenter every day adheres to using above-mentioned trial target sooner or later, test 1 week respectively, 2 weeks, 3 weeks, 4 weeks, 5
Test zone skin elasticity index R2, R5, R7 value (in test process, negative pressure is constant for 450mbar) after week.Index illustrates: skin
Elasticity indexes R2, R5, R7 are closer to 1, and the elasticity of skin is the best.
3. experimental result
Table 1 embodiment 4 crease-resistant facial cream test result table
| Test period | R2 | R5 | R7 |
| 1 | 0.459 | 0.448 | 0.426 |
| 2 | 0.598 | 0.578 | 0.542 |
| 3 | 0.706 | 0.695 | 0.674 |
| 4 | 0.878 | 0.859 | 0.845 |
| 5 | 0.946 | 0.921 | 0.901 |
Table 2 comparative example 1 crease-resistant facial cream test result table
| Test period | R2 | R5 | R7 |
| 1 | 0.372 | 0.362 | 0.351 |
| 2 | 0.456 | 0.425 | 0.405 |
| 3 | 0.621 | 0.568 | 0.555 |
| 4 | 0.695 | 0.589 | 0.564 |
| 5 | 0.732 | 0.669 | 0.658 |
Table 3 comparative example 2 crease-resistant facial cream test result table
| Test period | R2 | R5 | R7 |
| 1 | 0.437 | 0.406 | 0.398 |
| 2 | 0.552 | 0.535 | 0.526 |
| 3 | 0.658 | 0.635 | 0.624 |
| 4 | 0.735 | 0.685 | 0.675 |
| 5 | 0.802 | 0.784 | 0.759 |
As shown in table 1-3, comparing the crease-resistant facial cream of comparative example 1, comparative example 2, the crease-resistant facial cream of the present invention is increasing skin
Elastic, effect aspect of defying age has more preferable effect.It addition, the crease-resistant facial cream of use embodiment 4 is after the 3rd, 4 weeks, R2,
R5, R7 all rise substantially, the 5th week, and R2, R5, R7 value is all more than 0.9, and the skin elasticity index of experimenter has greatly improved.
Embodiment 11
Anti-wrinkle effect is fed back
1. test material: use crowd's number: 1400 people, sex: women, age: 30～60 years old, the embodiment of the present invention 1
～5, comparative example 1, the crease-resistant facial cream of comparative example 2.
2. experimental technique: use crowd is randomly divided into 7 groups, often organizes 200 people, uses embodiment 1～5, comparative example respectively
1, the crease-resistant facial cream of comparative example 21 month, 2 months, 3 months, 5 months, after 8 months, the positive rating situation of user feedback, see
Table 4,5.
3. feedback result:
Table 4 embodiment 1～5 positive rating feedback result table
Table 5 comparative example 1～2 positive rating feedback result table
As shown in table 4,5, comparing the crease-resistant facial cream of comparative example 1,2, the crease-resistant facial cream of the present invention has more preferable Consumer's Experience,
User the most all represents the present invention crease-resistant facial cream good penetrability, easily absorbs, can promote skin metabolism, has and calms down carefully
Stricture of vagina, reduces the effect of dry stricture of vagina and wrinkle, and especially in terms of wrinkle resistant, wrinkle removal, effect is the most notable.After the use of 8 months, for
Flat microgroove, subtract the positive rating of dry stricture of vagina project feedback still up to more than 93%.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any amendment, equivalent and the improvement etc. made within god and principle, within should be included in the scope of the present invention.
Claims (10)
1. the crease-resistant facial cream of chlorophyll, it is characterised in that include the raw material of following mass fraction: cyanophyceae chlorophyll 0.12～
0.56 part, antibacterial peptide 0.03～0.85 part, Radix Ginseng extractive solution 0.08～0.23 part, Herba Dendrobii extracting solution 0.12～0.25 part,
Fructus Mali pumilae extracting solution 0.12～0.31 part, Herba Menthae extracting solution 0.16～0.34 part, Herba Centellae extracting solution 0.11～0.22 part, Flos Rosae Chinensis
Extracting solution 0.14～0.39 part, olive oil 2.1～3.5 parts, Semen Tritici aestivi germ oil 2.2～2.8 parts, hickory oil 1.5～2.3 parts,
Oleum camelliae 3.1～3.9 parts, Radix Glycyrrhizae extract 0.24～0.33 part, Flos Caryophylli extracting solution 0.18～0.26 part, butanediol 2.3～
4.2 parts, glycerol 2.3～2.7 parts, glyceryl monostearate 2.1～3.8 parts, isopropyl myristate 2.5～3.6 parts, carbonic acid two
Monooctyl ester 2.3～3.5 parts, supercritical propolis 0.8～0.94 part, Lac regis apis 0.77～1.02 parts, deionized water 71.5～89.6 parts.
A kind of crease-resistant facial cream of chlorophyll the most according to claim 1, it is characterised in that include the former of following mass fraction
Material: cyanophyceae chlorophyll 0.44 part, antibacterial peptide 0.68 part, Radix Ginseng extractive solution 0.21 part, Herba Dendrobii extracting solution 0.23 part, Fructus Mali pumilae carry
Take liquid 0.28 part, Herba Menthae extracting solution 0.31 part, Herba Centellae extracting solution 0.21 part, Flos Rosae Chinensis extracting solution 0.35 part, olive oil 3.2
Part, Semen Tritici aestivi germ oil 2.6 parts, hickory oil 2.2 parts, Oleum camelliae 3.4 parts, Radix Glycyrrhizae extract 0.31 part, Flos Caryophylli extracting solution
0.23 part, butanediol 3.2 parts, glycerol 2.5 parts, glyceryl monostearate 2.6 parts, isopropyl myristate 3.1 parts, carbonic acid two pungent
Ester 3.2 parts, supercritical propolis 0.92 part, Lac regis apis 0.98 part, deionized water 86.2 parts.
A kind of crease-resistant facial cream of chlorophyll the most according to claim 1, it is characterised in that include the former of following mass fraction
Material: cyanophyceae chlorophyll 0.32 part, antibacterial peptide 0.45 part, Radix Ginseng extractive solution 0.12 part, Herba Dendrobii extracting solution 0.17 part, Fructus Mali pumilae carry
Take liquid 0.23 part, Herba Menthae extracting solution 0.23 part, Herba Centellae extracting solution 0.17 part, Flos Rosae Chinensis extracting solution 0.25 part, olive oil 2.5
Part, Semen Tritici aestivi germ oil 2.6 parts, hickory oil 2.1 parts, Oleum camelliae 3.3 parts, Radix Glycyrrhizae extract 0.25 part, Flos Caryophylli extracting solution
0.21 part, butanediol 4.1 parts, glycerol 2.6 parts, glyceryl monostearate 3.5 parts, isopropyl myristate 3.5 parts, carbonic acid two pungent
Ester 3.2 parts, supercritical propolis 0.89 part, Lac regis apis 0.92 part, deionized water 80.2 parts.
A kind of crease-resistant facial cream of chlorophyll the most according to claim 1, it is characterised in that include the former of following mass fraction
Material: cyanophyceae chlorophyll 0.35 part, antibacterial peptide 0.36 part, Radix Ginseng extractive solution 0.19 part, Herba Dendrobii extracting solution 0.21 part, Fructus Mali pumilae carry
Take liquid 0.26 part, Herba Menthae extracting solution 0.31 part, Herba Centellae extracting solution 0.18 part, Flos Rosae Chinensis extracting solution 0.22 part, olive oil 3.1
Part, Semen Tritici aestivi germ oil 2.5 parts, hickory oil 1.9 parts, Oleum camelliae 3.4 parts, Radix Glycyrrhizae extract 0.31 part, Flos Caryophylli extracting solution
0.22 part, butanediol 2.8 parts, glycerol 2.5 parts, glyceryl monostearate 2.4 parts, isopropyl myristate 2.7 parts, carbonic acid two pungent
Ester 2.9 parts, supercritical propolis 0.89 part, Lac regis apis 0.93 part, deionized water 87.2 parts.
5. the method for the crease-resistant facial cream of the chlorophyll prepared as described in any one of Claims 1 to 4, it is characterised in that include
Following steps:
(1) carry out grinding process by cyanophyceae, add the ethanol water of 60～80%wt by the feed liquid mass ratio of 1:15～32,
Ultrasonic-leaching 10～18min is carried out, after being filtered by lixiviating solution, at 60～85 DEG C under conditions of 23～36KHz, 32～41w
Carry out vacuum distilling concentration, obtain chlorophyll extractum；It is that chlorophyll extractum is added to 4% by 1:2～5 according to mass volume ratio
In the 92%wt ethanol water of wtNaOH, saponification 1～2h at 50～68 DEG C, then the concentration of ethanol is adjusted to 78%, pH
Value 6.8, adds saponification liquor quality 3～the zinc acetate of 4%, is cooled to 40～45 DEG C, stirs 0.5～1h, obtains cyanophyceae chlorophyll；
(2) by olive oil, Semen Tritici aestivi germ oil, hickory oil, Oleum camelliae, glyceryl monostearate, isopropyl myristate, carbon
Dioctyl phthalate is placed in oil phase pot, heating, after stirring and dissolving, is incubated standby；
(3) deionized water, butanediol, glycerol, Radix Glycyrrhizae extract, Flos Caryophylli extracting solution, antibacterial peptide are added in aqueous phase pot, be heated to
Dissolve completely, in the emulsifying pot that then suction is warmed-up, stirring, then by the material suction emulsifying pot of step (2), all
Matter；
(4) cooling, adds supercritical propolis, Lac regis apis, then homogenizing stirring；
(5) continue cooling, add cyanophyceae chlorophyll, Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extraction
Liquid, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution are stirred until homogeneous, and cooling discharging obtains product.
The method preparing the crease-resistant facial cream of chlorophyll the most according to claim 5, it is characterised in that in described step (1),
During ultrasonic-leaching, add the cellulase of 0.02～0.04%wt.
The method preparing the crease-resistant facial cream of chlorophyll the most according to claim 5, it is characterised in that in described step (5)
Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution, sweet
Grass extracting solution, the preparation technology of Flos Caryophylli extracting solution: respectively by Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, Herba Menthae, Herba Centellae liquid, Flos Rosae Chinensis,
Radix Glycyrrhizae, Flos Caryophylli shred, and are separately added in water according still further to mass volume ratio 1:12～18 and hot plate, and after boiling, continue to boil 2～3h,
Filter, collect extracting solution.
The method preparing the crease-resistant facial cream of chlorophyll the most according to claim 6, it is characterised in that in described step (5)
Radix Ginseng extractive solution, Herba Dendrobii extracting solution, Fructus Mali pumilae extracting solution, Herba Menthae extracting solution, Herba Centellae extracting solution, Flos Rosae Chinensis extracting solution, sweet
Grass extracting solution, Flos Caryophylli extracting solution before preparation, respectively to Radix Ginseng, Herba Dendrobii, Fructus Mali pumilae, Herba Menthae, Herba Centellae, Flos Rosae Chinensis, Radix Glycyrrhizae,
Flos Caryophylli carries out sterilization processing；The technique of sterilization: each plant after Xi Jinging, fruit are respectively placed in boiling water sterilization 3～5min, takes out
It is placed in water cooling.
The method preparing the crease-resistant facial cream of chlorophyll the most according to claim 5, it is characterised in that adding of described step (2)
Hot temperature is 80～85 DEG C；Step (3) heating-up temperature is 85～90 DEG C, homogenizing time is 5～10min；Step (4) is cooled to 60
～55 DEG C, mixing time be 3～7min；Step (5) is cooled to 45～40 DEG C, mixing time 3～7min, is cooled to room temperature.
10. according to the method preparing the crease-resistant facial cream of chlorophyll described in claim 5 or 7, it is characterised in that described filterer
Skill: soaked by 100 mesh nylon filtering cloths, is folded in 2 layers of funnel being laid in vacuum filtration, and edge is placed in outside funnel, opens
Vacuum filtration machine, vacuum is more than 0.07MPa, then pours in funnel by each liquid to be filtered respectively, filters.
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| CN109431908A (en) * | 2018-12-26 | 2019-03-08 | 广州市科能化妆品科研有限公司 | Skin whitening, moisturizing frost and preparation method thereof and skin-lightening cosmetic additive |
| CN109431908B (en) * | 2018-12-26 | 2022-03-11 | 广州市科能化妆品科研有限公司 | Whitening and moisturizing cream, preparation method thereof and whitening cosmetic additive |
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Effective date of registration: 20231018 Address after: 102, Building 1, No. 76, Xieshi Road, Shibi Street, Shibi Village, Panyu District, Guangzhou City, Guangdong Province, 510000 Patentee after: Guangdong Kewei Zhili Biopharmaceutical Co.,Ltd. Address before: Room 301, 401, 39 BAOYING Avenue, Guangzhou Free Trade Zone, Guangdong 510730 Patentee before: GUANGDONG COOWAY BIOTECHNOLOGY Co.,Ltd. |