CN106619319A - Antibacterial peptide-containing shower gel with function of relieving itching, and preparation method of shower gel - Google Patents
Antibacterial peptide-containing shower gel with function of relieving itching, and preparation method of shower gel Download PDFInfo
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Abstract
The invention provides antibacterial peptide-containing shower gel with a function of relieving itching. The shower gel is characterized by being prepared from the following components in parts by mass: 5-15 parts of alkyl glucoside, 1-10 parts of sodium cocoyl glycinate, 1-2 parts of squalane, 0.5-2 parts of cetostearyl alcohol, 1-5 parts of propylene glycol, 0.1-0.5 part of ethylene diamine tetraacetic acid tetrasodium, 0.1-0.3 part of citric acid, 0.1-2 parts of carbomer, 0.1-2 parts of sodium chloride, 5-15 parts of a centella asiatica extract, 1-3 parts of liquiritin, 0.1-2 parts of antibacterial peptide and 40-70 parts of water. The antibacterial peptide-containing shower gel belongs to the technical field of daily chemical products; the antibacterial peptide-containing shower gel with the function of relieving itching has good effects of resisting bacteria, relieving itching and protecting skin, and is stable and lasting in effects, good in safety and long in shelf life.
Description
Technical field
The invention belongs to cosmetics of everyday use technical field, more particularly to a kind of dew of the itching-relieving shower containing antibacterial peptide and its preparation side
Method.
Background technology
Shower cream be by surfactant and function conditioner modulate for cleaning, the washing of skin care uses
Product.With growth in the living standard, shower cream has realized the replacement to perfumed soap substantially, becomes necessity for life.Existing shower
Dew product mainly plays basic cleaning, moisturizing and refrigerant effect, although part shower cream product is declared with antibacterial, antipruritic
The effects such as, but effect is not ideal enough or prolongation with the holding time and effect gradually weakens.
Often add more surfactant, such as fatty alcohol polyoxyethylene ether sulfate in existing shower cream product
(AES), glycine betaine and fatty acid soaps etc., are usually used polytype surfactant and carry out collocation and use.Traditional surface
Activating agent shower cream is mainly made up of fatty alcohol polyoxyethylene ether sulfate and glycine betaine or fatty acid soaps, but fatty alcohol polyoxy second
The characteristics of alkene ether sulphate has adsorptivity strong, easily causes the sensation for being difficult to rinse, and fatty alcohol polyoxy second to consumer
Alkene ether sulphate can produce diox accessory substance during, can cause serious excitant to skin etc.；Fatty acid soaps fundamental mode
Although shower cream washability is good, due to its alkalescence it is stronger, it is larger to skin irritation, dry and astringent, tight, scabies is easily caused after washing
Itch.When the content of surfactant is higher, although with preferable cleaning effect, but the compositions such as normal sebum are easily taken away,
Long-Time Service is easily caused the bad reaction such as dry and astringent, red and swollen, itch.
Chinese patent application CN102579307 discloses a kind of Chinese medicine Radix zanthoxyli and moistens itching-relieving shower dew, including anion
Surfactant, nonionic surfactant and amphoteric surfactant etc., by Chinese medicine Radix zanthoxyli extract component and natural tea
Tree extract collective effect, the consumption with certain anti-inflammatory, analgesia, antibacterial, moisturizing effect, but surfactant it is higher and
Complicated component, is not suitable for Long-Time Service.
The natural plant extracts such as Chinese medicine often have certain antibacterial effect, and security is preferably, in shower cream product
In obtain wide application, but addition it is not high when antibacterial effect than relatively limited, generally require to add chemical preservative to prolong
Long shelf-life, addition is higher, is easily caused cost increase.
Therefore it provides a kind of surface-active contents are low, performance is rinsed with good, antibacterial, antipruritic effect are good and lasting
Shower cream it is significant.
The content of the invention
To solve problems of the prior art, inventor provides a kind of dew of the itching-relieving shower containing antibacterial peptide, by adding
Plus a certain amount of Gotu Kola P.E, liquiritin and antibacterial peptide, with good antibacterial, antipruritic, skin effect, and effect stability
Persistently, security is good, long shelf-life.Based on above-mentioned discovery, so as to complete the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of dew of the itching-relieving shower containing antibacterial peptide, including following component and its mass fraction：APG 5
～15 parts, 1～10 part of sodium cocoyl glycinate, 1～4 part of saualane, 0.5～2 part of cetostearyl alcohol, 1～5 part of propane diols, second
0.1～0.5 part of four sodium of ethylenediamine tetraacetic acid (EDTA), 0.1～0.3 part of citric acid, 0.1～2 part of Carbomer, 0.1～2 part of sodium chloride, accumulated snow
5～15 parts of careless extract, 1～3 part of liquiritin, 0.1～2 part of antibacterial peptide, 40～70 parts of water.
Using above-mentioned technical proposal, the kinds of surfactants for being used is few, by APG (non-ionic surface active
Agent) and sodium cocoyl glycinate (anion surfactant) be applied in combination, relatively low addition can realize good cleaning
Surfactant is avoided while effect may caused risk.Antibacterial peptide is that one kind that biological Jing in vivo inductions are produced has
The Small-molecule basic polypeptide of biologically active, is made up of 20～60 amino acid residues, and molecular weight has 2000～7000 or so
Broad spectrum antibiotic activity；Gotu Kola P.E has functions that anti-inflammatory, dispels aging cutin, can effectively dissolve the grease of pore depths
Dirt, dredge blockage hair follicle, beneficial to the discharge of toxin, improves skin quality；Liquiritin energy conditioning skin, antiallergy plays reduction body
It is irritating effect.By adding a certain amount of Gotu Kola P.E, liquiritin and antibacterial peptide, with good antibacterial, only
Itch, skin effect, and stable and durable effect, security is good, long shelf-life.
Preferably, the dew of the itching-relieving shower containing antibacterial peptide that the present invention is provided, including following component and its mass fraction：Alkyl
8～14 parts of glucosides, 3～8 parts of sodium cocoyl glycinate, 1～2 part of saualane, 0.5～2 part of cetostearyl alcohol, propane diols 2～5
Part, 0.2～0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1～0.3 part of citric acid, 0.5～2 part of Carbomer, 0.5～2 part of sodium chloride,
6～12 parts of Gotu Kola P.E, 2～3 parts of liquiritin, 0.2～1 part of antibacterial peptide, 50～68 parts of water.
It is highly preferred that the dew of the itching-relieving shower containing antibacterial peptide that the present invention is provided, including following component and its mass fraction：Alkane
10 parts of base glucosides, 5 parts of sodium cocoyl glycinate, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propane diols, ethylenediamine tetra-acetic acid four
0.3 part of sodium, 0.2 part of citric acid, 1 part of Carbomer, 1 part of sodium chloride, 8 parts of Gotu Kola P.E, 3 parts of liquiritin, antibacterial peptide 0.5
Part, 65 parts of water.
Preferably, the antibacterial peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.Antibacterial peptide DC can refer to patent
Method in 200510032743.8 is prepared, and the activity of antibacterial peptide DC is 5000IU/mL.
It is further preferred that the dew of the itching-relieving shower containing antibacterial peptide that the present invention is provided, also including 0.1～1 part of essence and/or
0.1～1 portion of pearling agent.
Correspondingly, the present invention also provides the preparation method that the itching-relieving shower containing antibacterial peptide reveals, and comprises the steps：
S1 weigh APG, sodium cocoyl glycinate, propane diols, Carbomer, tetrasodium ethylenediamine tetraacetate, citric acid and
Water is stirred and heated to 80～85 DEG C in first reactor, obtains material A；
S2 weighs saualane and cetostearyl alcohol in second reactor, is stirred and heated to 80～85 DEG C, adds described
In material A, 3～10min is quickly stirred, obtain material B；
The material B is cooled to 30～40 DEG C by S3, is weighed and is added sodium chloride, Gotu Kola P.E, liquiritin and resist
Bacterium peptide, stirs, cooling, obtains the itching-relieving shower containing antibacterial peptide and reveals.
Preferably, in step S1,82 DEG C are stirred and heated to.
Preferably, in step S2,82 DEG C are stirred and heated to.
Compared with prior art, beneficial effects of the present invention include：By APG and the group of sodium cocoyl glycinate
Conjunction is used, and relatively low addition can avoid surfactant while good cleaning effect is realized may caused risk；
By adding a certain amount of Gotu Kola P.E, liquiritin and antibacterial peptide, with good antibacterial, antipruritic, skin effect, and imitate
Fruit is stable lasting, and security is good, long shelf-life, can Long-Time Service without causing the bad reaction such as dry and astringent, red and swollen, itch.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, involved component and raw material is conventional commercial product, or can pass through the ordinary skill in the art
Means are obtained, for example：Gotu Kola P.E is purchased from Guilin Laiyin Biotechnology Co., Ltd., and No. CAS is 84696-21-9.
Itching-relieving shower of the embodiment one containing antibacterial peptide reveals
Itching-relieving shower containing antibacterial peptide dew, including following component and its mass fraction：10 parts of APG, the sweet ammonia of cocounut oil acyl
5 parts of sour sodium, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propane diols, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid,
1 part of Carbomer, 1 part of sodium chloride, 8 parts of Gotu Kola P.E, 3 parts of liquiritin, 0.5 part of antibacterial peptide DC, 65 parts of water.
Preparation method comprises the steps：
S1 weigh APG, sodium cocoyl glycinate, propane diols, Carbomer, tetrasodium ethylenediamine tetraacetate, citric acid and
Water is stirred and heated to 82 DEG C in first reactor, obtains material A；
S2 weighs saualane and cetostearyl alcohol in second reactor, is stirred and heated to 82 DEG C, adds the material A
In, 5min is quickly stirred, obtain material B；
The material B is cooled to 35 DEG C by S3, weighs and add sodium chloride, Gotu Kola P.E, liquiritin and antibacterial peptide,
Stir, cool down, obtain the itching-relieving shower containing antibacterial peptide and reveal.
Itching-relieving shower of the embodiment two containing antibacterial peptide reveals
Itching-relieving shower containing antibacterial peptide dew, including following component and its mass fraction：14 parts of APG, the sweet ammonia of cocounut oil acyl
3 parts of sour sodium, 2 parts of saualane, 2 parts of cetostearyl alcohol, 3 parts of propane diols, 0.2 part of tetrasodium ethylenediamine tetraacetate, 0.3 part of citric acid,
2 parts of Carbomer, 1 part of sodium chloride, 12 parts of Gotu Kola P.E, 2 parts of liquiritin, 0.5 part of antibacterial peptide DC, 58 parts of water.
Preparation method is similar with embodiment one.
Itching-relieving shower of the embodiment three containing antibacterial peptide reveals
Itching-relieving shower containing antibacterial peptide dew, including following component and its mass fraction：8 parts of APG, the sweet ammonia of cocounut oil acyl
8 parts of sour sodium, 2 parts of saualane, 1 part of cetostearyl alcohol, 5 parts of propane diols, 0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1 part of citric acid,
1 part of Carbomer, 1 part of sodium chloride, 6 parts of Gotu Kola P.E, 2 parts of liquiritin, 0.4 part of house fly antibiotic peptide, 65 parts of water.
Preparation method is similar with embodiment one.
Comparative example 1
Shower cream includes following component and its mass fraction：10 parts of APG, 5 parts of sodium cocoyl glycinate, saualane 2
Part, 1 part of cetostearyl alcohol, 3 parts of propane diols, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid, 1 part of Carbomer, sodium chloride
1 part, 11 parts of Gotu Kola P.E, 0.5 part of antibacterial peptide DC, 65 parts of water.
Comparative example 1 is with the difference of embodiment one：Without liquiritin, the mass fraction of Gotu Kola P.E increases.
Comparative example 2
Shower cream includes following component and its mass fraction：10 parts of APG, 5 parts of sodium cocoyl glycinate, saualane 2
Part, 1 part of cetostearyl alcohol, 3 parts of propane diols, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid, 1 part of Carbomer, sodium chloride
1 part, 11 parts of liquiritin, 0.5 part of antibacterial peptide DC, 65 parts of water.
Comparative example 2 is with the difference of embodiment one：Without Gotu Kola P.E, the mass fraction of liquiritin increases.
Comparative example 3
Itching-relieving shower containing antibacterial peptide dew, including following component and its mass fraction：10 parts of APG, the sweet ammonia of cocounut oil acyl
5 parts of sour sodium, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propane diols, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid,
1 part of Carbomer, 1 part of sodium chloride, 8 parts of honeysuckle flower extract, 3 parts of liquiritin, 0.5 part of antibacterial peptide DC, 65 parts of water.
Comparative example 3 is with the difference of embodiment one：Without Gotu Kola P.E, the honeysuckle flower extract containing equivalent.
The detection of the physical and chemical index of test example one
With reference to professional standard QB/T 1994-2013《Bath agent》, to the embodiment of the present invention one to embodiment three, comparative example 1
Detected to shower cream obtained in comparative example 3, the shower cream of each test group meets organoleptic indicator's requirement, while also complying with stable
Property etc. physical and chemical index require.
The irritating detection of test example two
With reference to version in 2015《Cosmetics safety technical specification》, the embodiment of the present invention one to embodiment three, comparative example 1 are to right
Shower cream carries out irritation test obtained in ratio 3, carries out dermoreaction scoring, as a result：Embodiment one to embodiment three, and
Comparative example 2 and the integral mean value of shower cream obtained in comparative example 3 are respectively less than 0.5, and skin irritatin intensity is nonirritant, embodiment
One integral mean value is minimum；And the integral mean value of shower cream obtained in comparative example 1 is 0.9, skin irritatin intensity is subexcite.
It can be seen that, liquiritin serves the irritating effect for reducing system of the present invention.
The detection of the anti-microbial property of test example three
With reference to standard GB/T 19877.2-2005《Extraordinary bath agent》, to embodiment one to embodiment three, comparative example 1 to
Shower cream carries out the detection of antibacterial effect obtained in comparative example 3, and to the shower cream after room temperature preservation 2 years the inspection of antibacterial effect is carried out
Survey, as a result as shown in table 1.
The bactericidal effect that itching-relieving shower of the table 1 containing antibacterial peptide reveals
As known from Table 1, the good anti-bacterial effect of shower cream obtained in the embodiment of the present invention one to embodiment three, to golden yellow Portugal
The sterilizing rate of grape coccus, ETEC and Candida albicans is up to more than 99%, and anti-microbial property is good, and comparative example 1 and contrast
Shower cream obtained in example 2 is substantially reduced due to lacking liquiritin or Gotu Kola P.E, sterilizing rate, and bactericidal effect is not as the present invention
Embodiment.After room temperature preservation 2 years, the present invention provide shower cream still have significant antibacterial effect, to staphylococcus aureus,
The sterilizing rate of ETEC and Candida albicans is up to more than 98%, and comparative example 1 substantially drops to the antibacterial effect of comparative example 3
It is low, especially 1 group of comparative example.It can be seen that, the common presence of Gotu Kola P.E, liquiritin and antibacterial peptide is stable for holding lasting
Antibacterial effect there is important function.
The antipruritic performance detection of test example four
Take 60 health SPF level cavys, body weight is 270～300g, be randomly divided into 6 groups, 10 per group, male and female half and half.Point
The big thigh of each group cavy back leg is not lost hair or feathers using sodium sulfide solution, respectively to embodiment one to three groups of embodiment, right after 24h
Ratio 1 to 3 groups of cavys of comparative example smear embodiment one, embodiment two, embodiment three, comparative example 1, the and of comparative example 2 at depilation
Shower cream obtained in comparative example 3, control group smears physiological saline, and applying amount is 4g/kg, is cleaned up after 3min, and 2 are smeared daily
It is secondary, continuously smear 7d；Last is smeared after 1h, is abraded with sand paper and form the surface of a wound at depilation, is allowed to rubescent but not bleeding, area
2cm2, start to drip 0.01% histamine phosphate 0.05mL in the surface of a wound after 10min, hereafter every 3min successively with 0.02%,
0.03%th, 0.04%, 0.05% ... increasing concen-trations, are only added dropwise every time by 0.05mL/.Until cavy later licks back leg when institute
Histamine phosphate's total amount (μ g) for giving is itch-threshold, records and compare the itch-threshold of each group cavy, as a result as shown in table 2.
The antipruritic effect that itching-relieving shower of the table 2 containing antibacterial peptide reveals
| Group | Itch-threshold (μ g) |
| Control group | 48.1±7.2 |
| One group of embodiment | 279.4±41.0**##◇◇△△ |
| Two groups of embodiment | 252.7±39.8**##◇◇△△ |
| Three groups of embodiment | 258.5±44.1**##◇◇△△ |
| 1 group of comparative example | 176.2±32.4** |
| 2 groups of comparative example | 151.8±31.6** |
| 3 groups of comparative example | 201.3±37.9** |
Note：Compared with control group, * * P ＜ 0.01；Compared with 1 group of comparative example,##P ＜ 0.01；Compared with 2 groups of comparative example,◇◇
P ＜ 0.01；Compared with 2 groups of comparative example,△△P ＜ 0.01.
As known from Table 2, the dew of the itching-relieving shower containing antibacterial peptide that the present invention is provided has good antipruritic effect, antipruritic effect
Comparative example 1 is substantially better than to 3 groups of comparative example (P ＜ 0.01).
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to assert
The present invention be embodied as be confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of without departing from present inventive concept, some simple deduction or replace can also be made, should all be considered as belonging to the present invention's
Protection domain.
Claims (8)
1. a kind of itching-relieving shower containing antibacterial peptide reveals, it is characterised in that：Including following component and its mass fraction：APG 5
～15 parts, 1～10 part of sodium cocoyl glycinate, 1～2 part of saualane, 0.5～2 part of cetostearyl alcohol, 1～5 part of propane diols, second
0.1～0.5 part of four sodium of ethylenediamine tetraacetic acid (EDTA), 0.1～0.3 part of citric acid, 0.1～2 part of Carbomer, 0.1～2 part of sodium chloride, accumulated snow
5～15 parts of careless extract, 1～3 part of liquiritin, 0.1～2 part of antibacterial peptide, 40～70 parts of water.
2. the itching-relieving shower containing antibacterial peptide according to claim 1 reveals, it is characterised in that：Including following component and its quality
Number：8～14 parts of APG, 3～8 parts of sodium cocoyl glycinate, 1～2 part of saualane, 0.5～2 part of cetostearyl alcohol, third
2～5 parts of glycol, 0.2～0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1～0.3 part of citric acid, 0.5～2 part of Carbomer, sodium chloride
0.5～2 part, 6～12 parts of Gotu Kola P.E, 2～3 parts of liquiritin, 0.2～1 part of antibacterial peptide, 50～68 parts of water.
3. the itching-relieving shower containing antibacterial peptide according to claim 2 reveals, it is characterised in that：Including following component and its quality
Number：10 parts of APG, 5 parts of sodium cocoyl glycinate, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propane diols, ethylenediamine
It is 0.3 part of four sodium of tetraacethyl, 0.2 part of citric acid, 1 part of Carbomer, 1 part of sodium chloride, 8 parts of Gotu Kola P.E, 3 parts of liquiritin, anti-
0.5 part of bacterium peptide, 65 parts of water.
4. the itching-relieving shower containing antibacterial peptide according to any one of claim 1 to 3 reveals, it is characterised in that：The antibacterial
Peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.
5. the itching-relieving shower containing antibacterial peptide according to any one of claim 1 to 3 reveals, it is characterised in that：Also include 0.1
～1 part of essence and/or 0.1～1 portion of pearling agent.
6. the preparation method that the itching-relieving shower containing antibacterial peptide according to claim 1 reveals, it is characterised in that：Including following step
Suddenly：
S1 weighs APG, sodium cocoyl glycinate, propane diols, Carbomer, the sodium of ethylenediamine tetraacetic acid (EDTA) four, citric acid and water in
In one reactor, 80～85 DEG C are stirred and heated to, obtain material A；
S2 weighs saualane and cetostearyl alcohol in second reactor, is stirred and heated to 80～85 DEG C, adds the material A
In, 3～10min is quickly stirred, obtain material B；
The material B is cooled to 30～40 DEG C by S3, weighs and add sodium chloride, Gotu Kola P.E, liquiritin and antibacterial peptide,
Stir, cool down, obtain the itching-relieving shower containing antibacterial peptide and reveal.
7. the preparation method that the itching-relieving shower containing antibacterial peptide according to claim 6 reveals, it is characterised in that：Step S1
In, it is stirred and heated to 82 DEG C.
8. the preparation method that the itching-relieving shower containing antibacterial peptide according to claim 6 reveals, it is characterised in that：Step S2
In, it is stirred and heated to 82 DEG C.
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| CN201710069995.0A CN106619319B (en) | 2017-02-08 | 2017-02-08 | A kind of itching-relieving shower dew and preparation method thereof containing antibacterial peptide |
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Cited By (1)
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| CN107802534A (en) * | 2017-11-10 | 2018-03-16 | 安徽科技学院 | A kind of common rabdosia leaf shower cream of auxiliary treatment dermatitis |
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| CN106619319B (en) | 2019-09-20 |
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Effective date of registration: 20230627 Address after: Room 101, No. 39 Baoying Avenue, Huangpu District, Guangzhou City, Guangdong Province, 510700, self-made unit 102 Patentee after: Guangdong Huasang Lixi Biotechnology Co.,Ltd. Address before: Room 301, 401, 39 BAOYING Avenue, Guangzhou Free Trade Zone, Guangdong 510730 Patentee before: GUANGDONG COOWAY BIOTECHNOLOGY Co.,Ltd. |