CN106619319B - A kind of itching-relieving shower dew and preparation method thereof containing antibacterial peptide - Google Patents
A kind of itching-relieving shower dew and preparation method thereof containing antibacterial peptide Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The present invention provides a kind of itching-relieving shower dew containing antibacterial peptide, it is characterised in that: including following component and its mass fraction: 5~15 parts of alkyl glycosides, 1~10 part of sodium cocoyl glycinate, 1~2 part of saualane, 0.5~2 part of cetostearyl alcohol, 1~5 part of propylene glycol, 0.1~0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1~0.3 part of citric acid, 0.1~2 part of carbomer, 0.1~2 part of sodium chloride, 5~15 parts of Gotu Kola P.E, 1~3 part of liquiritin, 0.1~2 part of antibacterial peptide, 40~70 parts of water.The invention belongs to daily chemical product technical field, the itching-relieving shower dew provided by the invention containing antibacterial peptide has good antibacterial, antipruritic, skin effect, and stable and durable effect, safety is good, long shelf-life.
Description
Technical field
The invention belongs to daily chemical product technical field more particularly to a kind of itching-relieving shower dew and its preparation side containing antibacterial peptide
Method.
Background technique
Shower cream is that the washing as made of surfactant and the modulation of function conditioner for cleaning, moisturizing the skin is used
Product.With the improvement of living standards, shower cream is realized to the substitution of perfumed soap substantially, become necessity for life.Existing shower
Dew product mainly plays basic cleaning, moisturizing and refrigerant effect, although part shower cream product is declared with antibacterial, antipruritic
And other effects, but the extension not ideal enough or with the holding time of effect and effect gradually weakens.
More surfactant, such as fatty alcohol polyoxyethylene ether sulfate are often added in existing shower cream product
(AES), glycine betaine and fatty acid soaps etc. carry out collocation use usually using a plurality of types of surfactants.Traditional surface
Activating agent shower cream is mainly made of fatty alcohol polyoxyethylene ether sulfate and glycine betaine or fatty acid soaps, but fatty alcohol polyoxy second
Alkene ether sulphate has the characteristics that strong adsorption, is easy the feeling for causing to be not easy to rinse to consumer, and fatty alcohol polyoxy second
Alkene ether sulphate can generate dioxanes by-product in the process, can cause serious irritation to skin etc.；Fatty acid soaps fundamental mode
It is larger to skin irritation since its alkalinity is stronger although shower cream washability is good, dry and astringent, tight, scabies is easy to cause after washing
Itch.When the content of surfactant is higher, although having preferable cleaning effect, it is easy to take away the ingredients such as normal sebum,
Long-time service is easy to cause the adverse reactions such as dry and astringent, red and swollen, itch.
Chinese patent application CN102579307 discloses a kind of moist itching-relieving shower dew of Chinese medicine Radix zanthoxyli, including anion
Surfactant, nonionic surfactant and amphoteric surfactant etc. pass through Chinese medicine Radix zanthoxyli extract component and natural tea
Set the collective effect of extracting solution, there is certain anti-inflammatory, analgesia, antibacterial, moisturizing effect, but surfactant dosage it is higher and
Complicated component is not suitable for long-term use.
The natural plant extracts such as Chinese medicine often have certain antibacterial effect, and safety is preferable, in shower cream product
In obtain wide application, but antibacterial effect generally requires addition chemical preservative to prolong than relatively limited when additive amount is not high
The long shelf-life, additive amount is higher, is easy to cause cost increase.
Therefore it provides a kind of surface-active contents are low, there is good flushing performance, antibacterial, antipruritic effect are good and lasting
Shower cream be of great significance.
Summary of the invention
To solve problems of the prior art, inventor provides a kind of itching-relieving shower dew containing antibacterial peptide, by adding
Add a certain amount of Gotu Kola P.E, liquiritin and antibacterial peptide, there is good antibacterial, antipruritic, skin effect, and effect stability
Persistently, safety is good, long shelf-life.Based on above-mentioned discovery, thereby completing the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of itching-relieving shower dew containing antibacterial peptide, including following component and its mass fraction: alkyl glycosides 5
~15 parts, 1~10 part of sodium cocoyl glycinate, 1~4 part of saualane, 0.5~2 part of cetostearyl alcohol, 1~5 part of propylene glycol, second
0.1~0.5 part of four sodium of ethylenediamine tetraacetic acid (EDTA), 0.1~0.3 part of citric acid, 0.1~2 part of carbomer, 0.1~2 part of sodium chloride, accumulated snow
5~15 parts of careless extract, 1~3 part of liquiritin, 0.1~2 part of antibacterial peptide, 40~70 parts of water.
By adopting the above technical scheme, used kinds of surfactants is few, passes through alkyl glycosides (non-ionic surface active
Agent) and sodium cocoyl glycinate (anionic surfactant) be applied in combination, lower additive amount can realize good cleaning
The risk that surfactant may cause is avoided while effect.Antibacterial peptide is that the one kind generated in organism through induction has
The Small-molecule basic polypeptide of bioactivity is made of 20~60 amino acid residues, and molecular weight has 2000~7000 or so
Broad spectrum antibiotic activity；Gotu Kola P.E have effects that it is anti-inflammatory, dispel aging cutin, can effectively dissolve the grease of pore depths
Dirt, dredge blockage hair follicle improve skin quality conducive to the discharge of toxin；Liquiritin energy conditioning skin, antiallergy play reduction body
It is irritating effect.By adding a certain amount of Gotu Kola P.E, liquiritin and antibacterial peptide, there is good antibacterial, stop
Itch, skin effect, and stable and durable effect, safety is good, long shelf-life.
Preferably, the itching-relieving shower dew provided by the invention containing antibacterial peptide, including following component and its mass fraction: alkyl
8~14 parts of glucosides, 3~8 parts of sodium cocoyl glycinate, 1~2 part of saualane, 0.5~2 part of cetostearyl alcohol, propylene glycol 2~5
Part, 0.2~0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1~0.3 part of citric acid, 0.5~2 part of carbomer, 0.5~2 part of sodium chloride,
6~12 parts of Gotu Kola P.E, 2~3 parts of liquiritin, 0.2~1 part of antibacterial peptide, 50~68 parts of water.
It is highly preferred that the itching-relieving shower dew provided by the invention containing antibacterial peptide, including following component and its mass fraction: alkane
10 parts of base glucosides, 5 parts of sodium cocoyl glycinate, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propylene glycol, ethylenediamine tetra-acetic acid four
0.3 part of sodium, 0.2 part of citric acid, 1 part of carbomer, 1 part of sodium chloride, 8 parts of Gotu Kola P.E, 3 parts of liquiritin, antibacterial peptide 0.5
Part, 65 parts of water.
Preferably, the antibacterial peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.Antibacterial peptide DC can refer to patent
200510032743.8 method in is prepared, and the activity of antibacterial peptide DC is 5000IU/mL.
It is further preferred that it is provided by the invention containing antibacterial peptide itching-relieving shower dew, further include 0.1~1 part of essence and/or
0.1~1 portion of pearling agent.
Correspondingly, the present invention also provides the preparation method of the itching-relieving shower dew containing antibacterial peptide, include the following steps:
S1 weigh alkyl glycosides, sodium cocoyl glycinate, propylene glycol, carbomer, tetrasodium ethylenediamine tetraacetate, citric acid and
Water is stirred and heated to 80~85 DEG C, obtains material A in first reactor；
S2 weighs saualane and cetostearyl alcohol in second reactor, is stirred and heated to 80~85 DEG C, described in addition
In material A, 3~10min is quickly stirred, material B is obtained；
The material B is cooled to 30~40 DEG C by S3, is weighed and is added sodium chloride, Gotu Kola P.E, liquiritin and resist
Bacterium peptide, stirs evenly, cooling, obtains the itching-relieving shower dew containing antibacterial peptide.
Preferably, in the step S1,82 DEG C are stirred and heated to.
Preferably, in the step S2,82 DEG C are stirred and heated to.
Compared with prior art, the beneficial effect comprise that passing through the group of alkyl glycosides and sodium cocoyl glycinate
It closes and uses, lower additive amount can avoid the risk that surfactant may cause while realizing good cleaning effect；
By adding a certain amount of Gotu Kola P.E, liquiritin and antibacterial peptide, there is good antibacterial, antipruritic, skin effect, and imitate
Fruit is stablized persistently, and safety is good, long shelf-life, can be used for a long time without will lead to the adverse reactions such as dry and astringent, red and swollen, itch.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, related component and raw material are conventional commercial product, or can pass through the ordinary skill in the art
Means obtain, such as: Gotu Kola P.E is purchased from Guilin Laiyin Biotechnology Co., Ltd., and No. CAS is 84696-21-9.
Itching-relieving shower dew of the embodiment one containing antibacterial peptide
Itching-relieving shower dew containing antibacterial peptide, including following component and its mass fraction: 10 parts of alkyl glycosides, the sweet ammonia of cocounut oil acyl
5 parts of sour sodium, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propylene glycol, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid,
1 part of carbomer, 1 part of sodium chloride, 8 parts of Gotu Kola P.E, 3 parts of liquiritin, 0.5 part of antibacterial peptide DC, 65 parts of water.
Preparation method includes the following steps:
S1 weigh alkyl glycosides, sodium cocoyl glycinate, propylene glycol, carbomer, tetrasodium ethylenediamine tetraacetate, citric acid and
Water is stirred and heated to 82 DEG C, obtains material A in first reactor；
S2 weighs saualane and cetostearyl alcohol in second reactor, is stirred and heated to 82 DEG C, and the material A is added
In, 5min is quickly stirred, material B is obtained；
The material B is cooled to 35 DEG C by S3, weighs and be added sodium chloride, Gotu Kola P.E, liquiritin and antibacterial peptide,
It stirs evenly, it is cooling, obtain the itching-relieving shower dew containing antibacterial peptide.
Itching-relieving shower dew of the embodiment two containing antibacterial peptide
Itching-relieving shower dew containing antibacterial peptide, including following component and its mass fraction: 14 parts of alkyl glycosides, the sweet ammonia of cocounut oil acyl
3 parts of sour sodium, 2 parts of saualane, 2 parts of cetostearyl alcohol, 3 parts of propylene glycol, 0.2 part of tetrasodium ethylenediamine tetraacetate, 0.3 part of citric acid,
2 parts of carbomer, 1 part of sodium chloride, 12 parts of Gotu Kola P.E, 2 parts of liquiritin, 0.5 part of antibacterial peptide DC, 58 parts of water.
Preparation method is similar with embodiment one.
Itching-relieving shower dew of the embodiment three containing antibacterial peptide
Itching-relieving shower dew containing antibacterial peptide, including following component and its mass fraction: 8 parts of alkyl glycosides, the sweet ammonia of cocounut oil acyl
8 parts of sour sodium, 2 parts of saualane, 1 part of cetostearyl alcohol, 5 parts of propylene glycol, 0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1 part of citric acid,
1 part of carbomer, 1 part of sodium chloride, 6 parts of Gotu Kola P.E, 2 parts of liquiritin, 0.4 part of house fly antibiotic peptide, 65 parts of water.
Preparation method is similar with embodiment one.
Comparative example 1
Shower cream includes following component and its mass fraction: 10 parts of alkyl glycosides, 5 parts of sodium cocoyl glycinate, saualane 2
Part, 1 part of cetostearyl alcohol, 3 parts of propylene glycol, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid, 1 part of carbomer, sodium chloride
1 part, 11 parts of Gotu Kola P.E, 0.5 part of antibacterial peptide DC, 65 parts of water.
Comparative example 1 and the difference of embodiment one are: being free of liquiritin, the mass fraction of Gotu Kola P.E increases.
Comparative example 2
Shower cream includes following component and its mass fraction: 10 parts of alkyl glycosides, 5 parts of sodium cocoyl glycinate, saualane 2
Part, 1 part of cetostearyl alcohol, 3 parts of propylene glycol, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid, 1 part of carbomer, sodium chloride
1 part, 11 parts of liquiritin, 0.5 part of antibacterial peptide DC, 65 parts of water.
Comparative example 2 and the difference of embodiment one are: being free of Gotu Kola P.E, the mass fraction of liquiritin increases.
Comparative example 3
Itching-relieving shower dew containing antibacterial peptide, including following component and its mass fraction: 10 parts of alkyl glycosides, the sweet ammonia of cocounut oil acyl
5 parts of sour sodium, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propylene glycol, 0.3 part of tetrasodium ethylenediamine tetraacetate, 0.2 part of citric acid,
1 part of carbomer, 1 part of sodium chloride, 8 parts of honeysuckle flower extract, 3 parts of liquiritin, 0.5 part of antibacterial peptide DC, 65 parts of water.
Comparative example 3 and the difference of embodiment one are: being free of Gotu Kola P.E, the honeysuckle flower extract containing equivalent.
The detection of one physical and chemical index of test example
Referring to professional standard QB/T 1994-2013 " bath agent ", to the embodiment of the present invention one to embodiment three, comparative example 1
It is detected to shower cream made from comparative example 3, the shower cream of each test group meets organoleptic indicator's requirement, while also complying with stabilization
Property etc. physical and chemical indexes requirement.
The irritating detection of test example two
Referring to version " cosmetics safety technical specification " in 2015, the embodiment of the present invention one to embodiment three, comparative example 1 were to right
Shower cream made from ratio 3 carries out irritation test, carries out dermoreaction scoring, as a result: embodiment one to embodiment three, and
The integral mean value of shower cream made from comparative example 2 and comparative example 3 is respectively less than 0.5, and skin irritatin intensity is nonirritant, embodiment
One integral mean value is minimum；And the integral mean value of shower cream made from comparative example 1 is 0.9, skin irritatin intensity is subexcite.
As it can be seen that liquiritin plays the role of reducing the irritating of system of the present invention.
The detection of three anti-microbial property of test example
Referring to standard GB/T 19877.2-2005 " extraordinary bath agent ", to embodiment one to embodiment three, comparative example 1 to
Shower cream made from comparative example 3 carries out the detection of antibacterial effect, and the inspection of antibacterial effect is carried out to the shower cream after room temperature preservation 2 years
It surveys, the results are shown in Table 1.
The bactericidal effect of itching-relieving shower dew of the table 1 containing antibacterial peptide
As known from Table 1, the good anti-bacterial effect of shower cream made from the embodiment of the present invention one to embodiment three, to golden yellow Portugal
For the sterilizing rate of grape coccus, escherichia coli and Candida albicans up to 99% or more, anti-microbial property is good, and comparative example 1 and comparison
Shower cream made from example 2 is substantially reduced due to lacking liquiritin or Gotu Kola P.E, sterilizing rate, and bactericidal effect is not as good as the present invention
Embodiment.After room temperature preservation 2 years, shower cream provided by the invention still has significant antibacterial effect, to staphylococcus aureus,
The sterilizing rate of escherichia coli and Candida albicans is up to 98% or more, and the antibacterial effect of comparative example 1 to comparative example 3 obviously drops
It is low, especially 1 group of comparative example.As it can be seen that Gotu Kola P.E, liquiritin and the common of antibacterial peptide exist for keeping stablizing persistently
Antibacterial effect play a significant role.
The antipruritic performance detection of test example four
Taking SPF grades of cavys of 60 health, weight is 270~300g, it is randomly divided into 6 groups, every group 10, half male and half female.Point
Each group cavy back leg large share is not lost hair or feathers using sodium sulfide solution, in for 24 hours afterwards respectively to embodiment one to three groups of embodiment, right
Ratio 1 to 3 groups of cavys of comparative example smear embodiment one, embodiment two, embodiment three, comparative example 1,2 and of comparative example at depilation
Shower cream made from comparative example 3, control group smear physiological saline, clean up after applying amount 4g/kg, 3min, smear 2 daily
It is secondary, continuously smear 7d；After last smears 1h, with the surface of a wound is formed at sand paper scratch depilation, it is allowed to rubescent but not bleeding, area
2cm2, start after 10min to drip 0.01% histamine phosphate 0.05mL in the surface of a wound, hereafter successively use 0.02% every 3min,
0.03%, 0.04%, 0.05% ... increasing concen-trations are only added dropwise by 0.05mL/ every time.Until cavy later licks back leg when institute
The histamine phosphate's total amount (μ g) given is itch-threshold, records and compare the itch-threshold of each group cavy, the results are shown in Table 2.
The antipruritic effect of itching-relieving shower dew of the table 2 containing antibacterial peptide
| Group | Itch-threshold (μ g) |
| Control group | 48.1±7.2 |
| One group of embodiment | 279.4±41.0**##◇◇△△ |
| Two groups of embodiment | 252.7±39.8**##◇◇△△ |
| Three groups of embodiment | 258.5±44.1**##◇◇△△ |
| 1 group of comparative example | 176.2±32.4** |
| 2 groups of comparative example | 151.8±31.6** |
| 3 groups of comparative example | 201.3±37.9** |
Note: compared with the control group, * * P < 0.01；Compared with 1 group of comparative example,##P < 0.01；Compared with 2 groups of comparative example,◇◇
P < 0.01；Compared with 2 groups of comparative example,△△P < 0.01.
As known from Table 2, the itching-relieving shower dew provided by the invention containing antibacterial peptide has good antipruritic effect, antipruritic effect
Comparative example 1 is substantially better than to 3 groups of comparative example (P < 0.01).
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (8)
1. a kind of itching-relieving shower dew containing antibacterial peptide, it is characterised in that: including following component and its mass fraction: alkyl glycosides 5
~15 parts, 1~10 part of sodium cocoyl glycinate, 1~2 part of saualane, 0.5~2 part of cetostearyl alcohol, 1~5 part of propylene glycol, second
0.1~0.5 part of four sodium of ethylenediamine tetraacetic acid (EDTA), 0.1~0.3 part of citric acid, 0.1~2 part of carbomer, 0.1~2 part of sodium chloride, accumulated snow
5~15 parts of careless extract, 1~3 part of liquiritin, 0.1~2 part of antibacterial peptide, 40~70 parts of water.
2. the itching-relieving shower dew according to claim 1 containing antibacterial peptide, it is characterised in that: including following component and its quality
Number: 8~14 parts of alkyl glycosides, 3~8 parts of sodium cocoyl glycinate, 1~2 part of saualane, 0.5~2 part of cetostearyl alcohol, third
2~5 parts of glycol, 0.2~0.5 part of tetrasodium ethylenediamine tetraacetate, 0.1~0.3 part of citric acid, 0.5~2 part of carbomer, sodium chloride
0.5~2 part, 6~12 parts of Gotu Kola P.E, 2~3 parts of liquiritin, 0.2~1 part of antibacterial peptide, 50~68 parts of water.
3. the itching-relieving shower dew according to claim 2 containing antibacterial peptide, it is characterised in that: including following component and its quality
Number: 10 parts of alkyl glycosides, 5 parts of sodium cocoyl glycinate, 2 parts of saualane, 1 part of cetostearyl alcohol, 3 parts of propylene glycol, ethylenediamine
0.3 part of four sodium of tetraacethyl, 1 part of carbomer, 1 part of sodium chloride, 8 parts of Gotu Kola P.E, 3 parts of liquiritin, resists 0.2 part of citric acid
0.5 part of bacterium peptide, 65 parts of water.
4. the itching-relieving shower dew according to any one of claim 1 to 3 containing antibacterial peptide, it is characterised in that: the antibacterial
Peptide is selected from house fly antibiotic peptide or antibacterial peptide DC.
5. the itching-relieving shower dew according to any one of claim 1 to 3 containing antibacterial peptide, it is characterised in that: further include 0.1
~1 part of essence and/or 0.1~1 portion of pearling agent.
6. the preparation method of the itching-relieving shower dew according to claim 1 containing antibacterial peptide, it is characterised in that: including walking as follows
It is rapid:
S1 weigh alkyl glycosides, sodium cocoyl glycinate, propylene glycol, carbomer, tetrasodium ethylenediamine tetraacetate, citric acid and water in
In first reactor, 80~85 DEG C are stirred and heated to, material A is obtained；
S2 weighs saualane and cetostearyl alcohol in second reactor, is stirred and heated to 80~85 DEG C, and the material A is added
In, 3~10min is quickly stirred, material B is obtained；
The material B is cooled to 30~40 DEG C by S3, weighs and be added sodium chloride, Gotu Kola P.E, liquiritin and antibacterial peptide,
It stirs evenly, it is cooling, obtain the itching-relieving shower dew containing antibacterial peptide.
7. the preparation method of the itching-relieving shower dew according to claim 6 containing antibacterial peptide, it is characterised in that: the step S1
In, it is stirred and heated to 82 DEG C.
8. the preparation method of the itching-relieving shower dew according to claim 6 containing antibacterial peptide, it is characterised in that: the step S2
In, it is stirred and heated to 82 DEG C.
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| CN105560102A (en) * | 2015-12-25 | 2016-05-11 | 名臣健康用品股份有限公司 | Natural health-care hair-washing and hair-caring composition |
| CN106265266A (en) * | 2016-08-26 | 2017-01-04 | 广东科玮生物技术股份有限公司 | A kind of containing chlorophyllous Shu Min bath gel |
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| FR2938193B1 (en) * | 2008-11-07 | 2011-08-12 | Expanscience Lab | MEDICAMENT OR DERMATOLOGICAL COMPOSITION COMPRISING A PEPTIDE AVOCADO EXTRACT FOR THE TREATMENT AND PREVENTION OF PRUPIT |
| CN103315932B (en) * | 2013-06-05 | 2014-11-12 | 片仔癀（上海）生物科技研发有限公司 | Itching-relieving body wash and preparation method thereof |
| KR101595440B1 (en) * | 2014-01-17 | 2016-02-18 | 조선대학교 산학협력단 | The effect of antimicrobial activity of CMA3 analogue peptide derived from CA-MA |
| CN106236687B (en) * | 2016-08-26 | 2018-01-05 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant face cream of chlorophyll and preparation method thereof |
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| CN105560102A (en) * | 2015-12-25 | 2016-05-11 | 名臣健康用品股份有限公司 | Natural health-care hair-washing and hair-caring composition |
| CN106265266A (en) * | 2016-08-26 | 2017-01-04 | 广东科玮生物技术股份有限公司 | A kind of containing chlorophyllous Shu Min bath gel |
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