CN107854329B - A kind of antibacterial moisturizing foam hand cleanser of easy wash type and preparation method thereof - Google Patents
A kind of antibacterial moisturizing foam hand cleanser of easy wash type and preparation method thereof Download PDFInfo
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- CN107854329B CN107854329B CN201711311687.0A CN201711311687A CN107854329B CN 107854329 B CN107854329 B CN 107854329B CN 201711311687 A CN201711311687 A CN 201711311687A CN 107854329 B CN107854329 B CN 107854329B
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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Abstract
The present invention relates to a kind of easy antibacterial moisturizing foam hand cleanser of wash type and preparation method thereof, and the hand cleanser includes following component: lauric acid, myristic acid, tetra- sodium of EDTA-, potassium hydroxide, bacteriostatic agent, phytosphingosine, oleth -5- phosphate, conditioner, glycerol, preservative, washing fragrance and water.Hand cleanser foam produced by the present invention is fine and smooth, lasting, strong, is easy to rinse, and cleaning effect is good, and biocidal property is strong, and antimicrobial spectrum is wide, and low to skin irritation, degreasing power is weak, has certain moistness, dry sensation will not be generated after washing, preparation process is simple, and low energy consumption.
Description
Technical field
The present invention relates to Irrigations to sterilize field, and in particular to a kind of antibacterial moisturizing foam hand cleanser of easy wash type and its
Preparation method.
Background technique
Hand cleanser is daily cleaning supplies, compared with traditional perfumed soap, soap, avoids these solids and becomes easily infected by
The defect of dirt and bacterium on hand, it is a possibility that reducing cross-infection, more easy for consumers to accept.Currently, on the market
Hand sanitizer formula usually selects some surfactants and fungicide to be compounded, to achieve the effect that cleaning, sterilization.Wherein,
Two major classes are broadly divided into according to the selection of surfactant, the first kind is the biggish system of irritation, usually selects anion table
Face activating agent, amphoteric surfactant and a little nonionic surfactant etc. are primary raw material (such as dodecyl polyoxyethylene
Ether sulfate AES, lauryl sulfate K12, cocamide propyl betaine CAB etc.)；Second class is that irritation is lower
System, usually selecting amino acid surfactant is primary raw material.Though the hand cleanser of these two types formula has certain detergency,
Have the disadvantage that 1. foam is soft, not stiffening enough, foam seems no texture；2. lather quickness is slow, wash by rubbing with the hands be difficult to generate it is rich
Rich foam is easy defoaming；It is washed down 3. foam is more difficult, repeatedly rinsing still has foam residual.In addition, with anion, amphoteric ion
It is higher with hand cleanser alkalinity that nonionic surfactant is primary raw material, it is too strong to skin degreasing power, it washes too dry and astringent, does not have
Moisturizing effect.
On the other hand, the antibacterial not wide spectrum of hand cleanser on the market, many hand cleanser can only inhibit staphylococcus aureus, no
It can inhibit the Pseudomonas such as Escherichia coli, in order to obtain better fungistatic effect, expand antimicrobial spectrum, generally use chemical bacteriostatic agent and plant
Object antipathogenic composition is compounded, as Publication No. CN 104840402A Chinese patent application " a kind of foam disinfectant hand cleanser and
It is prepared and application " with sodium sulfate of polyethenoxy ether of fatty alcohol, Cocoamidopropyl betaine, lauryl sodium sulfate, poly- mountain
Pear ester -20, essence, bamboo charcoal essential oil, triclosan, second alcohol and water pass through anion, amphoteric ion, nonionic as raw material is prepared
Surfactant compound is played synergistic cleaning action, while being compounded with bamboo charcoal essential oil and triclosan, and acquisition is preferably killed
Bacterium effect, it is also effective to Escherichia coli, Candida albicans, staphylococcus aureus or pseudomonas aeruginosa.However, compounding is planted
Object essential oil not only increases cost, also needs the volatility for preventing essential oil, increases the difficulty of preparation process.
Parachlorometaxylenol (PCMX) is one of most effective antipathogenic composition of hand cleanser, to most Gram-negative bacterias and
Positive bacteria, fungi and mould have killing effect, are a kind of hypotoxicity antibacterial agents, compared to other fungicide such as povidone iodine,
Nano silver etc., inexpensively, but its solubility in water is very low, is difficult to dissolve in most of hand cleanser, needs to add for price
Alcohols solubilizer, these solubilizer will increase the irritation of skin and limit product suitable for no alcohol product while addition.
In addition, certain alcohols solubilizer can reduce its activity while increasing PCMX solubility, such as: polyethylene glycol can be generated with PCMX and be formed
Reaction is closed, PCMX is inactivated.On the other hand, the system containing parachlorometaxylenol generally requires to dissolve by heating, and causes to add work
Skill is complicated, and energy consumption increases.In addition, there will be research has shown that a large amount of surfactant addition can reduce fungicide, if PCMX is (to chlorine
Meta-xylene phenol) fungistatic effect.
Therefore, a kind of foam liquid soap system for being applicable in PCMX as bacteriostatic agent is developed, and there is easy washability, is efficiently protected
Wet effect and easy to operate, the preparation process that low energy consumption has great importance.
Summary of the invention
In order to solve the problems existing in the prior art, the purpose of the present invention is to provide a kind of easy antibacterial moisturizing foams of wash type
Hand cleanser and preparation method thereof, the product foam is fine and smooth, lasting, strong, is easy to rinse, and cleaning effect is good, and biocidal property is strong, suppression
Bacterium spectrum is wide, and low to skin irritation, degreasing power is weak, has certain moistness, and dry sensation, preparation process letter will not be generated after washing
Single, low energy consumption.
Technical scheme is as follows:
A kind of antibacterial moisturizing foam hand cleanser of easy wash type comprising following weight percentage components:
Lauric acid 4~12%, myristic acid 1~5%, tetra- sodium 0.05~0.15% of EDTA-, potassium hydroxide 2~6%, suppression
Microbial inoculum 0.1~0.5%, phytosphingosine 0.2~1.2%, oleth -5- phosphoesterase 30 .5~2%, conditioner 0.1~1%,
Glycerol 2~10%, preservative 0.1~0.5%, washing fragrance 0.1~0.5% and water 65~80%.
Preferably, the hand cleanser includes following weight percentage components: lauric acid 4~8%, myristic acid 2~
4%, tetra- sodium 0.05~0.1% of EDTA-, potassium hydroxide 2~4%, bacteriostatic agent 0.1~0.4%, phytosphingosine 0.6~1%,
Oleth -5- phosphate 1~2%, conditioner 0.4~1%, glycerol 4~10%, preservative 0.1~0.3%, washing fragrance
0.1~0.4% and water 70~80%.
Preferably, the hand cleanser include following weight percentage components: lauric acid 6%, myristic acid 3%,
Tetra- sodium 0.1% of EDTA-, potassium hydroxide 3%, bacteriostatic agent 0.3%, phytosphingosine 1%, oleth -5- phosphate 1.5%,
Conditioner 0.6%, glycerol 9%, preservative 0.3%, washing fragrance 0.2% and water 75%.
Further, the conditioner is panthenyl triacetate and inositol hexaphosphate with the mass ratio group of 1:0.1~1
At.
Preferably, the conditioner is panthenyl triacetate and inositol hexaphosphate with the mass ratio group of 1:0.2~0.4
At.
Preferably, the conditioner is that panthenyl triacetate and inositol hexaphosphate are formed with the mass ratio of 1:0.25.
Further, the bacteriostatic agent is parachlorometaxylenol.
Further, the preservative is DMDM hydantoin, Kathon CG, phenyllactic acid, Phenoxyethanol, methylisothiozoline
Ketone, parabens or Sensiva SC50.
Preferably, the preservative be can be the DMDM hydantoin used in 4~11 ranges in pH.
Further, the present invention selects Verbena officinalis or blue windbell as washing fragrance.
In addition, the present invention also provides the preparation method of the antibacterial moisturizing foam hand cleanser of easy wash type described in one kind, packet
It includes following steps: by raw material by above-mentioned formulation ratio, lauric acid, myristic acid and 1/3 water being mixed, is added in reaction kettle, stirs
Lower addition potassium hydroxide and bacteriostatic agent are mixed, until material is completely dissolved, successively oleth -5- phosphate, conditioning is then added
Agent, phytosphingosine, tetra- sodium of EDTA-, moisturizer, preservative and washing fragrance and residue 2/3 water, stir evenly to get.
Different from conventional hand cleanser, the present invention washes one's hands liquid system without other surfactants, but by raw material
Potassium hydroxide and lauric acid, myristic acid occur to neutralize hair and should generate soap base, form soap base system, make product foam it is fine and smooth,
Persistently, strong, the good appearance of foam liquid soap and texture are assigned, simultaneously because being free of other surfactants, is made obtained
The transparent clarified solution of hand cleanser, washes down speed with very fast, only need it is primary cross water can thorough still residual, and viscosity is low
In 50mPa.s, extremely low viscosity keeps product quality highly stable,
In addition, the pH with conventional hand cleanser is 4~7, slant acidity or partial neutral compare, the pH higher of hand cleanser of the present invention,
In alkalinity, pH is 9~10.5, and the high pH of soap base is unfavorable for bacterial growth, and synergistic effect occurs with PCMX, is obtained preferable
Fungistatic effect.Simultaneously because the preparation process of hand cleanser of the present invention contains saponification, potassium hydroxide is dissolved in the process
Water can release amount of heat, and offer energy can be dissolved to fatty acid, and saponification can also release heat, keep reaction temperature,
PCMX can be dissolved in the soap base system of high pH at low temperature, and reaction process can save production energy without heating, simplify production work
Skill reduces production cost.
Simultaneously as hand cleanser of the present invention is in high pH, more conventional hand cleanser is big to the irritation of skin, this also gives
The practical application of hand cleanser of the present invention brings many challenges.Although studies have shown that the sebaceous glands of human body has the pH value of skin
There is certain neutralization, pH value is the skin of pH 5.4, and skin surface pH value connects after being washed with the alkaline soap of pH 10.6
Be pH 7 after nearly 8,30min, be pH 6.3 after 60min, almost restore to original state, but during this recovery I
Need to endure the dry tight, phenomenon of itching of alkaline skin bring, and the people for frequently washing one's hands, it is daily duplicate to destroy, is extensive
It is multiple, it will increase the burden of skin, accelerate skin aging.Surprisingly, the inventors discovered that being compounded in hand cleanser
The a certain amount of conditioner being made of panthenyl triacetate and inositol hexaphosphate can accelerate skin pH to restore, use trier
After the hand cleanser of the high pH of the present invention, it can restore in 15min to normal weak acid number range 5~6, achieve unexpected skill
Art effect.
The present invention phytosphingosine in liquid system of washing one's hands is the main component for constituting ceramide III and VI, structure with
The sphingomyelins of human skin is close, is easy to be absorbed and used, can restore the basic elastic construction of skin, delay skin aging.Institute
One phosphoric acid ester is similar to the structure of phospholipid of skin surface in the oleth -5- phosphate ester structure stated, and compatibility is strong, is easy
Absorption is on the skin；The main moisturizing grease of skin is C12~18The oleic acid of fatty grease, other end can supplement skin moisture-keeping most
Strong C18Fatty acid, forming a film to protect in epidermis moisturizes the skin.Both phytosphingosines and oleth -5- phosphate phase
Mutually collaboration not only has preferable skin-moisturizing, skin skin-care effect, may additionally facilitate the recovery of skin barrier function, to reduce system
To the irritation of skin.
Compared with prior art, present invention has an advantage that
(1) hand cleanser provided by the invention is the soap base system of the extremely low viscosity of high ph-values, and foam is fine and smooth, lasting, strong, matter
Measure it is highly stable, rinse it is very fast, only need it is primary cross water can thorough still residual, although in addition, the pH value of system is higher,
But the pH value of skin can be made to restore within a short period of time to normal value after rinsing, it is small to the irritation of skin, there is certain taste
Moisten skin care effect, dry tight, phenomenon of itching will not be generated after flushing.
(2) hand cleanser provided by the invention has stronger bacteriostasis, and antimicrobial spectrum is wide, and stoste is to Staphylococcus aureus
Bacterium, Escherichia coli, Candida albicans, pseudomonas aeruginosa act on 1min, and bacteriostasis rate is up to 99.90% or more.
(3) hand cleanser reaction process provided by the invention can save production energy without heating, simplify production technology,
Reduce production cost.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the present invention is not limited only to following embodiment.
The preparation of embodiment 1-3 and comparative example 1-4 foam liquid soap
Embodiment 1-3 and comparative example 1-4 foam liquid soap include the component of weight percent meter shown in following table:
The preparation of 1 foam liquid soap of embodiment the following steps are included:
Raw material is pressed into above-mentioned formulation ratio, lauric acid, myristic acid and 1/3 water are mixed, is added in reaction kettle, under stirring
Potassium hydroxide and bacteriostatic agent is added, until material is completely dissolved, successively oleth -5- phosphate, conditioner, plant is then added
Object sphingol, tetra- sodium of EDTA-, moisturizer, preservative and washing fragrance and residue 2/3 water, stir evenly to get.
The preparation reference implementation example 1 of embodiment 2-3 and comparative example 1-4 foam liquid soap.
Wherein, 1 foam liquid soap of comparative example the difference from embodiment 1 is that, be free of oleth -5- phosphate, and phase
The content of glycerol should be increased.2 foam liquid soap of comparative example the difference from embodiment 1 is that, conditioner contains only panthenyl triacetate,
Without inositol hexaphosphate.3 foam liquid soap of comparative example the difference from embodiment 1 is that, conditioner contains only inositol hexaphosphate,
Without panthenyl triacetate.4 foam liquid soap of comparative example the difference from embodiment 1 is that, be free of conditioner, and increase accordingly sweet
The content of oil.
Test example one, physicochemical property detection
Physicochemical property detection is carried out to foam liquid soap made from the embodiment of the present invention 1 respectively, and is carried out with commercial product
Comparison, as a result see the table below shown in 1:
1 hand cleanser physical and chemical index testing result of table
The results show that hand cleanser produced by the present invention is compared with commercial product, viscosity is lower, pH higher, meta-alkalescence, but two
Person all has preferable stability.
Test example two, skin irritation test
70 female volunteers are selected, 7 groups, respectively embodiment 1-3 group, comparative example 1-4 group are divided into, it is every group 10, right
Foam liquid soap made from 1-3 of the embodiment of the present invention, comparative example 1-4 should be given.Each group smears hand cleanser 0.5ml, with the double-deck yarn
Cloth (2.5cm × 2.5cm) and polyethylene film covering, are fixed, the 4h after smearing uses water with nonirritant adhesive plaster and bandage
Cleaning removes residue.Respectively at removal tested material 1h, 12h, for 24 hours, 48h observation local skin reaction and pressed by the scoring of table 2
Table 3 determines the rank of skin irritatin intensity, as a result see the table below shown in 4.
2 skin wound repair standards of grading of table are judged
| Erythema is formed | Reaction scoring | Oedema is formed | Reaction scoring |
| Nothing | 0 | Nothing | 0 |
| It is visible reluctantly | 1 | It is visible reluctantly | 1 |
| Obviously | 2 | Cutaneous protuberance is clearly outlined | 2 |
| Seriously | 3 | Oedema swells about 1mm | 3 |
| Aubergine erythema, and have eschar | 4 | Oedema is swelled more than 1mm | 4 |
3 skin irritation intensity evaluation standard of table
| Skin irritation index | Stimulus intensity rank |
| 0~< 0.5 | It is nonirritant |
| 0.5~< 2.0 | Subexcite |
| 2.0~< 6.0 | Medium irritation |
| 6.0~< 8.0 | Strong and stimulating |
4 skin irritation test result of table
| Observing time | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| 1h | 0 | 0 | 0 | 0 | 0.7 | 0.5 | 1.4 |
| 12h | 0 | 0 | 0 | 0 | 1.1 | 0.8 | 2.3 |
| 24h | 0 | 0 | 0 | 0 | 0.3 | 0.2 | 0.7 |
| 48h | 0 | 0 | 0 | 0 | 0 | - | 0.1 |
| It is total | 0 | 0 | 0 | 0 | 2.1 | 1.5 | 4.5 |
The results show that the no positive reaction of foam liquid soap made from 1-3 of the embodiment of the present invention and comparative example 1 occurs, skin
Skin irritation grade is 0 grade, illustrates that foam liquid soap provided by the invention is non-stimulated to skin, product safety, mild.And it compares
Panthenyl triacetate or inositol hexaphosphate are contained only in the foam liquid soap system obtained of example 2-4, or is free of panthenol three simultaneously
Acetic acid esters and inositol hexaphosphate can obviously increase the irritation of hand cleanser.
Test example three, the test of foam liquid soap using effect
160 volunteers are chosen, embodiment 1-3 group, comparative example 1-4 group and commercial product group are divided into, it is corresponding to use this hair
Hand cleanser made from bright embodiment 1-3 group, comparative example 1-4 group and commercially available foam liquid soap carry out sensory evaluation, count will
Hope person is to the Evaluation results of product, shown in table 5 specific as follows:
5 each group using effect evaluation result of table
The results show that the using effect of foam liquid soap various aspects made from 1-3 of the embodiment of the present invention is superior to comparative example
1-4 and commercial product.By comparative example 1 it is found that oleth -5- phosphate is free of in system, to hand cleanser spumescence, irritation
Be easy to rinse influential effect it is little but very big to moistening skin-care influential effect.By comparative example 2-4 it is found that being contained only in system
Panthenyl triacetate or inositol hexaphosphate, or panthenyl triacetate and inositol hexaphosphate are free of simultaneously, to hand cleanser foam
Property and be easy to rinse influential effect it is little but very big to irritation and moistening skin-care influential effect.
Test example four, the test of foam liquid soap fungistatic effect
According to GB/15979-2002 appendix C hand cleanser made from the defined test method measurement embodiment of the present invention 1
Fungistatic effect, and be compared with the fungistatic effect of commercially available foam liquid soap, as a result as shown in table 6 below:
6 each group fungistatic effect evaluation result of table
| Detection project | Embodiment 1 (bacteriostasis rate %) | Commercial product (bacteriostasis rate %) |
| Staphylococcus aureus | 99.94 | 99.90 |
| Escherichia coli | 99.92 | 99.85 |
| Candida albicans | 99.94 | 99.60 |
| Pseudomonas aeruginosa | 99.90 | 99.72 |
The results show that hand cleanser made from the embodiment of the present invention 1 has preferable fungistatic effect, to Staphylococcus aureus
Bacterium, Escherichia coli, Candida albicans and pseudomonas aeruginosa bacteriostasis rate up to 99.9% or more, be better than commercial product.
Test example five, foam liquid soap restore timeliness using rear hand skin pH and evaluate
It is detected respectively using acid-base scale of skin tester using hand cleanser made from the embodiment of the present invention 1 and comparative example 2-4
The situation of change of hand skin ph afterwards, and be compared with certain commercially available washes with soap (pH 9.2), it see the table below 7 institutes with result
Show:
7 foam liquid soap of table restores timeliness evaluation result using rear hand skin pH
| Time (min) | Embodiment 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Commercial product |
| 1 | 8.4 | 8.3 | 8.4 | 8.5 | 8.0 |
| 5 | 7.2 | 7.7 | 7.8 | 8.2 | 7.8 |
| 10 | 6.2 | 7.2 | 7.4 | 7.9 | 7.7 |
| 15 | 5.8 | 6.6 | 6.7 | 7.4 | 7.6 |
| 30 | 5.7 | 6.0 | 6.1 | 7.0 | 7.1 |
| 45 | 5.7 | 5.7 | 5.8 | 6.6 | 6.7 |
| 60 | 5.6 | 5.6 | 5.6 | 6.3 | 6.4 |
The results show that using hand cleanser made from the embodiment of the present invention 1, hand skin surface pH value is about 8.3~
8.5, also than commercially available product meta-alkalescence, but restore rapidly in 15min to pH5.7, recovery effects are significantly better than comparative example 2-4
Soap is used with commercially available wash.By comparative example 2-4 it is found that containing only panthenyl triacetate or inositol hexaphosphate in system, or simultaneously not
Containing panthenyl triacetate and inositol hexaphosphate, hand cleanser obtained restores skin pH effect and is substantially less than embodiment 1.More than
Height of the invention is advantageously reduced with the conditioner that panthenyl triacetate and inositol hexaphosphate form the result shows that adding in system
The irritation of pH soap base system, makes hand skin pH value restore normal value rapidly.
The above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
Limitation of the invention, protection scope of the present invention should be defined by the scope defined by the claims..For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change
It also should be regarded as protection scope of the present invention into retouching.
Claims (8)
1. a kind of antibacterial moisturizing foam hand cleanser of easy wash type, which is characterized in that the hand cleanser includes following weight percent
The component of ratio:
Lauric acid 4~12%, myristic acid 1~5%, tetra- sodium 0.05~0.15% of EDTA-, potassium hydroxide 2~6%, bacteriostatic agent
0.1~0.5%, phytosphingosine 0.2~1.2%, oleth -5- phosphoesterase 30 .5~2%, conditioner 0.1~1%, glycerol
2~10%, preservative 0.1~0.5%, washing fragrance 0.1~0.5% and water 65~80%, wherein the conditioner is panthenol
Triacetate and inositol hexaphosphate are formed with the mass ratio of 1:0.1~1.
2. the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 1, which is characterized in that the hand cleanser packet
It includes following weight percentage components:
Lauric acid 4~8%, myristic acid 2~4%, tetra- sodium 0.05~0.1% of EDTA-, potassium hydroxide 2~4%, bacteriostatic agent 0.1
~0.4%, phytosphingosine 0.6~1%, oleth -5- phosphate 1~2%, conditioner 0.4~1%, glycerol 4~
10%, preservative 0.1~0.3%, washing fragrance 0.1~0.4% and water 70~80%.
3. the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 2, which is characterized in that the hand cleanser packet
It includes following weight percentage components:
Lauric acid 6%, myristic acid 3%, tetra- sodium 0.1% of EDTA-, potassium hydroxide 3%, bacteriostatic agent 0.3%, phytosphingosine
1%, oleth -5- phosphate 1.5%, conditioner 0.6%, glycerol 9%, preservative 0.3%, washing fragrance 0.2% and water
75%.
4. the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 1, which is characterized in that the conditioner is
Panthenyl triacetate and inositol hexaphosphate are formed with the mass ratio of 1:0.2~0.4.
5. the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 4, which is characterized in that the conditioner is
Panthenyl triacetate and inositol hexaphosphate are formed with the mass ratio of 1:0.25.
6. the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 1 to 3, which is characterized in that the suppression
Microbial inoculum is parachlorometaxylenol.
7. the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 1 to 3, which is characterized in that described is anti-
Rotten agent is DMDM hydantoin.
8. the preparation method of the antibacterial moisturizing foam hand cleanser of easy wash type according to claim 1 to 3, feature exist
In, comprising the following steps:
Raw material is pressed into above-mentioned formulation ratio, lauric acid, myristic acid and 1/3 water are mixed, is added in reaction kettle, is added with stirring
Then successively oleth -5- phosphate, conditioner, plant sheath is added until material is completely dissolved in potassium hydroxide and bacteriostatic agent
Ammonia alcohol, tetra- sodium of EDTA-, glycerol, preservative and washing fragrance and residue 2/3 water, stir evenly to get.
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| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
| CN111588645A (en) * | 2020-07-09 | 2020-08-28 | 江苏欧亚立日化有限公司 | Foam bacteriostatic and disinfectant hand sanitizer easy to rinse and preparation method thereof |
| CN113288842A (en) * | 2021-07-15 | 2021-08-24 | 厦门力嘉诚生物科技有限公司 | Hyaluronic acid skin-moistening bacteriostatic hand sanitizer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142423A (en) * | 2013-04-01 | 2013-06-12 | 珀莱雅化妆品股份有限公司 | Soap-based cleansing cream not generating soap scum |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142423A (en) * | 2013-04-01 | 2013-06-12 | 珀莱雅化妆品股份有限公司 | Soap-based cleansing cream not generating soap scum |
Non-Patent Citations (1)
| Title |
|---|
| 泡沫洗手液对致病菌的抑菌作用;朴泰训等;《第十一届中国化妆品学术研讨会论文集》;20180615;表1，2，第179页右栏第2段 |
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