JP2007031376A - Hair and scalp detergent, percutaneous absorption accelerator and percutaneous absorption accelerating method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair and scalp detergent which has excellent lathering, detergency, and sterilizing power and accelerates percutaneous absorption of a hair restoration active ingredient in a hair restorer to be used thereafter and a method of accelerating percutaneous absorption of the hair restoration active ingredient. <P>SOLUTION: The hair and scalp detergent comprises (A) an anionic surface active agent, (B) a percutaneous absorption accelerating substance, and (C) a sterilizing component. The method of accelerating percutaneous absorption of a hair restorer active ingredient comprises washing the scalp with the above hair and scalp detergent composition before using a hair restorer containing a percutaneous absorption accelerator and the hair restorer active ingredient. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention has excellent foaming, detergency and sterilizing power, and promotes the transdermal absorption of a hair growth active ingredient to be used thereafter, a transdermal absorption enhancer, and a transdermal absorption of a hair growth active ingredient. It is about the promotion method.

  The number of people suffering from hair loss such as hair loss and thin hair is increasing year by year, and in a modern stress society, alopecia is becoming younger and higher hair growth effects are expected. For example, for the purpose of preventing skin aging and activating cells by external application to the scalp, a hair restorer using 6-benzylaminopurine (6-benzyladenine) and its derivatives (Patent Document 1: Special) No. 05-320028) and skin cosmetics (Patent Document 2: Japanese Patent Application Laid-Open No. 07-233037) have been proposed. In addition, for the purpose of preventing aging due to the activating effect on the cell tissue of a living body, a hair nourishing agent using an extract of Coleus-Forscolli (Patent Document 3: Japanese Patent Laid-Open No. 08-176005, Patent Document 4: Japanese Patent Laid-Open No. 09) -157138)) has been proposed.

  As described above, in the field of hair restoration agents, new effective hair growth ingredients are being developed. However, the development of new hair restoration active ingredients requires a large development cost and a long development period. It was difficult to search for effective ingredients that exceeded the effects of the hair-growth active ingredients introduced. From the above, a technique that can easily improve the effects of existing hair-growth active ingredients has been desired. In addition, the following is mentioned as a prior art document relevant to this invention.

JP 05-320028 A Japanese Patent Application Laid-Open No. 07-233037 Japanese Patent Laid-Open No. 08-176005 JP 09-157138 A JP 2003-327510 A JP 2002-284627 A Japanese Patent Laid-Open No. 09-110652

  The present invention has been made in view of the above circumstances, and has a hair and scalp cleaning agent that has excellent foaming, detergency and sterilizing power, and promotes percutaneous absorption of a hair-growth active ingredient in a hair-growth agent used thereafter, It is an object of the present invention to provide a skin absorption enhancer and a method for promoting percutaneous absorption of a hair growth active ingredient.

  As a result of intensive studies to achieve the above-mentioned object, the present inventor pays attention to increasing the efficiency of existing hair-growth active ingredients, and is incorporated into a hair-growth agent in a manner that is low in cost and does not feel complicated for consumers. It was thought that by promoting percutaneous absorption of a known hair-growth active ingredient, the hair-growth effect could be improved without developing a new active ingredient. As a result, (A) a hair and scalp cleaning agent containing an anionic surfactant is blended with a specific (B) transdermal absorption enhancer, so that the hair-growth active ingredient in the hair-growth agent used thereafter is transdermally. It has been found that absorption is promoted. Furthermore, it has been found that by blending (C) a bactericidal component, itching and dandruff of the scalp, which contributes to hair loss, suppresses the growth of microorganisms that cause inflammation, and further enhances the effect of active hair-growth ingredients. It came to be completed. Thus, the percutaneous absorption of the hair-growth active ingredient can be promoted only with the hair / scalp cleaning agent, and the effect of the hair-growth active ingredient can be easily improved together with excellent foaming and detergency.

  Accordingly, the present invention comprises (A) an anionic surfactant, (B) a transdermal absorption enhancer, and (C) a hair / scalp cleanser and transdermal absorption enhancer containing a bactericidal component, and an active ingredient for hair restorer. Provided is a method for promoting percutaneous absorption of an active ingredient for hair restorer, characterized by washing the scalp with the hair / scalp cleaner composition before using the hair restorer.

  According to the present invention, a hair / scalp cleaning agent that has excellent foaming, detergency and sterilizing power, and that promotes percutaneous absorption of a hair-growth active ingredient contained in a hair-growth agent used thereafter, a transdermal absorption enhancer, And a method for promoting percutaneous absorption of a hair-growth active ingredient.

  (A) component of this invention is an anionic surfactant, and can be used individually by 1 type or in combination of 2 or more types. The anionic surfactant removes excess sebum from the scalp and further assists in the function of (B) a transdermal absorption enhancer. Moreover, (A) The foaming power of an anionic surfactant and a cleaning agent can improve the effect of the hair restorer as a pre-care agent for a hair restorer containing a hair-growth active ingredient without taking a single effort after washing the hair. .

  Examples of (A) anionic surfactants include polyoxyalkylene alkyl ether sulfates, alkyl sulfates, alkylbenzene sulfonates, α-olefin sulfonates, and fatty acid salts. Among these, polyoxyalkylene alkyl ether sulfate is preferable. Examples of the alkyl group in the polyoxyalkylene alkyl ether sulfate include octyl group, nonyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group and the like. And a dodecyl group, a tridecyl group or a tetradecyl group is preferred. Examples of the alkylene moiety include polyoxyethylene and polyoxypropylene, and polyoxyethylene is particularly preferable. Moreover, the range of the total average addition mole number in preferable polyoxyethylene alkyl ether sulfate is 2-4. Examples of these counter ions include alkali metal salts such as sodium, alkaline earth metal salts, ammonium salts, and alkanolamine salts.

  (A) The anionic surfactant is preferably contained in the hair / scalp cleaning agent in an amount of 5 to 50% by mass, more preferably 10 to 30% by mass. If the amount is less than 5% by mass, the effect of removing excess sebum may be low, and foaming power may be insufficient. If the amount exceeds 50% by mass, the viscosity of the hair / scalp cleaning agent increases, making it difficult to remove from the container. Or the stability of the hair / scalp cleaning agent may deteriorate.

  The component (B) of the present invention is a transdermal absorption promoting substance, and is not particularly limited as long as it is a component that improves the transdermal absorbability of the hair restoring active ingredient. (B) Examples of the percutaneous absorption promoting substance include polyalkylene glycols, cationic surfactants, amine oxides, etc., which are liquid at room temperature, as components that enhance percutaneous absorption without impairing the function as a hair / scalp cleaning agent. Each can be used alone or in appropriate combination of two or more.

  Examples of the polyalkylene glycol that is liquid at room temperature include polyethylene glycol, polypropylene glycol, and polyethylene glycol / polypropylene glycol copolymers, and polyethylene glycol is preferred. Polyethylene glycol that takes a liquid state at room temperature indicates a softening point of 25 ° C. or lower, specifically, a weight average molecular weight of 200 (−65 to −50 ° C.) and a weight average molecular weight of 300. (-15 to -10 ° C), weight average molecular weight 400 (-6 to 8 ° C), and weight average molecular weight 600 (17 to 22 ° C).

The softening point is a temperature at which the ratio of the plastic flow rate and stress of a low indeterminate character at low temperature becomes a soft state with remarkable fluidity after a relatively narrow temperature range with increasing temperature. It is a state in which flow is recognized within a time of about ¹ to 10 s at a temperature at which the viscosity becomes substantially 10 ¹⁰ to 10 ¹¹ Pa · s. That is, it is a temperature at which polyethylene glycol having a high viscosity, which is an indefinite characteristic at a low temperature, is gradually heated and becomes soft. If the softening point is 25 ° C. or lower, it is defined as a liquid at room temperature. Although it depends on the heating rate of the heating, it is a temperature at which the paste is softened suddenly, so the whole is not liquid at the softening point, and the liquid and indeterminate characters may be dispersed. However, alkylene glycol that is liquid at room temperature indicates that once it is liquid, it remains liquid at 25 ° C.

  The method for measuring the softening point is not particularly defined as long as the temperature at which the softening state can be measured, but the temperature of the furnace is increased using, for example, a heat measuring device (Mettler Toledo, FP900 thermosystem) equipped with a softening point measurement unit. A method in which the temperature at which the oil droplets drip from the paste-like sample when measured can be measured optically.

  Although there is no restriction | limiting in particular in the polyethyleneglycol to be used, More specifically, polyethyleneglycol 200, polyethyleneglycol 300, polyethyleneglycol 400, polyethyleneglycol 600 can be used, Among these, polyethyleneglycol 300 is preferable. When the weight average molecular weight is less than 200, the skin is irritated, and when it exceeds 600, the transdermal absorbability may be lowered.

  The weight average molecular weight of polyethylene glycol can be measured by using an average molecular weight test such as polyethylene glycol 200 based on cosmetic raw materials. That is, 42 g of phthalic anhydride is taken and added to 1 L of a light-shielded bottle containing 300 mL of freshly distilled pyridine, shaken vigorously, and then allowed to stand for 16 hours or more. 25 mL of this solution is accurately weighed and placed in an approximately 200 mL pressure-resistant co-converged bottle. To this, approximately 0.8 g of polyethylene glycol is precisely weighed, and the mixture is sealed and placed in a water bath heated to 98 ° C. ± 2 ° C. After maintaining at 98 ° C. ± 2 ° C. for 30 minutes, remove the bottle from the water bath and leave it in the air until it reaches room temperature. Next, 50 mL of 0.5N sodium hydroxide solution is accurately added, and this solution is titrated with 0.5N sodium hydroxide solution. At this time, 5 drops of phenolphthalein / pyridine solution (1 → 100) is used as an indicator. However, the end point of the titration is when the liquid exhibits a light red color lasting 15 seconds. Perform a blank test in the same manner. The weight average molecular weight is calculated from the following formula.

ａ：空試験における０．５Ｎ水酸化ナトリウム液の消費量（ｍＬ）
ｂ：試料の試験における０．５Ｎ水酸化ナトリウム液の消費量（ｍＬ）

a: Consumption of 0.5N sodium hydroxide solution in the blank test (mL)
b: Consumption of 0.5N sodium hydroxide solution in sample test (mL)

（式中、Ｒ¹は炭素数８〜３２の飽和又は不飽和の一価炭化水素基、Ｒ²は炭素数１〜３２の飽和又は不飽和の一価炭化水素基、Ｒ³は炭素数１〜６のアルキル基、又はフェニル基、Ｒ⁴は炭素数１〜６のアルキル基、又は水素原子を示す。Ｘ^-はＣｌ^-、Ｂｒ^-、Ｉ^-、ＣＨ₃ＯＳＯ₃ ^-、又はＣ₂Ｈ₅ＯＳＯ₃ ^-を示す。）
対イオンとしては４級アンモニウム塩の場合には、塩化物イオン、臭化物イオン、ヨウ化物イオン、メチル硫酸イオン等が挙げられる。また脂肪族アミンとしては塩酸塩、硫酸塩等が挙げられる。 Examples of the cationic surfactant include aliphatic amines and quaternary ammonium salts represented by the following general formula (1).

Wherein R ¹ is a saturated or unsaturated monovalent hydrocarbon group having 8 to 32 carbon atoms, R ² is a saturated or unsaturated monovalent hydrocarbon group having 1 to 32 carbon atoms, and R ³ is 1 carbon atom. 6 alkyl group, or a phenyl group, R ⁴ represents an alkyl group, or a hydrogen atom having 1 to 6 carbon atoms .X ^- is ^{Cl -, Br -, I -} , CH 3 OSO 3 -, or C ₂ H ₅ OSO ₃ ^- show a).
As a counter ion, in the case of a quaternary ammonium salt, a chloride ion, a bromide ion, an iodide ion, a methyl sulfate ion, and the like can be given. Examples of the aliphatic amine include hydrochloride and sulfate.

  Among these, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, dialkyldimethylammonium chloride, benzalkonium chloride and the like are preferable, and alkyltrimethylammonium chloride such as stearyltrimethylammonium chloride and behenyltrimethylammonium chloride is more preferable.

［式中、Ｒ⁵は炭素数８〜３２の飽和又は不飽和の一価炭化水素基、Ｒ⁶及びＲ⁷はそれぞれ独立に水素原子、炭素数１〜６のアルキル基もしくはヒドロキシアルキル基、又は下記構造式（３）

（式中、Ｒ⁸は水素原子、メチル基又はエチル基を示し、ｑは１〜３の整数を示す。）
で表される一価置換基を示す。ｐは０又は５以下の整数を示す。］ Examples of the amine oxide include amine oxides represented by the following general formula (2).

[Wherein, R ⁵ is a saturated or unsaturated monovalent hydrocarbon group having 8 to 32 carbon atoms, R ⁶ and R ⁷ are each independently a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a hydroxyalkyl group, or The following structural formula (3)

(Wherein R ⁸ represents a hydrogen atom, a methyl group or an ethyl group, and q represents an integer of 1 to 3)
The monovalent substituent represented by these is shown. p represents 0 or an integer of 5 or less. ]

  Among these, lauryl dimethylamine oxide, coconut oil dimethylamine oxide, stearyl dimethylamine oxide, lauryl dihydroxyamine oxide, polyoxyethylene lauryl dimethylamine oxide (p = 3: average added mole number of ethylene oxide of 3 moles) and the like are preferable.

  (B) As the percutaneous absorption promoting substance, polyalkylene glycol, cationic surfactant and amine oxide which are liquid at room temperature may be used alone or in combination of two or more. (B) The transdermal absorption promoting substance is represented by (B1) a polyalkylene glycol that is liquid at room temperature, and (B2) a cationic surfactant represented by the above general formula (1) or the above general formula (2). By using either one or both of these amine oxides together, high performance as a hair / scalp cleaning agent is obtained, and percutaneous absorption of the hair-growth active ingredient is improved. A preferred combination is a combination of a polyalkylene glycol which is liquid at room temperature and an amine oxide represented by the above general formula (2).

  When blending liquid polyalkylene glycol at room temperature, it is preferably blended in the hair / scalp cleaning agent in an amount of 0.1 to 30% by mass, more preferably 1 to 15% by mass, and even more preferably 2 to 10% by mass. If the amount of the polyalkylene glycol that is liquid at room temperature is too small, it may not be possible to obtain a sufficient transdermal absorption promoting effect of the hair-growth active ingredient, and if it is too much, the stability of the hair / scalp cleaning agent may be deteriorated. .

  When the cationic surfactant and / or amine oxide is blended, it is preferably 0.05 to 10% by mass, more preferably 0.1 to 5% by mass, and still more preferably 0.3 to 0.3% in the hair / scalp cleaning agent. 2% by mass. When the amount is less than 0.05% by mass, the effect of promoting the percutaneous absorption of the hair-growth active ingredient may not be obtained. When the amount exceeds 10% by mass, the feeling such as stickiness may be lowered. In addition, a compounding quantity is the total amount, when a cationic surfactant and an amine oxide are used together.

  The component (C) of the present invention is a bactericidal component. By using a sterilizing component, it is possible to suppress the growth of various bacteria on the scalp, to keep the scalp clean by suppressing inflammation and dandruff, and to enhance the effect of the hair-growth active ingredient. The sterilizing component is not particularly limited as long as it can sterilize or suppress the activity of bacteria on the scalp, and can be used alone or in combination of two or more.

（式中、Ｒ⁹、Ｒ¹⁰及びＲ¹¹はそれぞれ独立に、炭素数１〜３のアルキル基、水酸基又は水素原子を示し、Ａはカルボキシル基又はその塩を示す。） As the (C) bactericidal component, an aromatic carboxylic acid represented by the following general formula (4) and / or a salt thereof is preferably used in terms of good bactericidal power and less irritation to the skin.

(In the formula, R ⁹ , R ¹⁰ and R ¹¹ each independently represents an alkyl group having 1 to 3 carbon atoms, a hydroxyl group or a hydrogen atom, and A represents a carboxyl group or a salt thereof.)

  Among these, benzoate is preferable, and sodium benzoate is more preferable. The benzoate may be added as a benzoate or may be used as a benzoate by adding benzoic acid and adding an alkali agent separately in the composition. On the other hand, bactericides in which the carboxyl group of A is an ester (for example, p-hydroxybenzoate ester) are not preferred in terms of strong irritation to the skin, and cationic bactericides are complexed with (A) an anionic surfactant. In some cases, it is difficult to exert sterilizing power.

  (C) The sterilizing component can be used within a range where there is no problem in safety, but is preferably added in an amount of 0.1 to 1% by mass in the hair / scalp cleaning agent. If the amount is less than 0.1% by mass, the effect of promoting the percutaneous absorption of a hair-growth active ingredient may not be obtained. If the amount exceeds 1% by mass, irritation to the skin may occur.

  In addition to the above components, the hair / scalp cleaning agent of the present invention contains (D) a cationic polymer compound, (E) a silicone compound, and (F) a nonionic surfactant and / or an amphoteric surfactant other than those described above. It is preferable to do.

  (D) By mix | blending a cationic high molecular compound, the catch at the time of a rinse can be reduced and hair loss can be reduced. Examples of the cationic polymer compound present in the dissolved state in the hair / scalp cleaning agent having the above composition include, for example, a homopolymer of dimethyldiallylammonium chloride, a copolymer of dimethyldiallylammonium chloride / acrylamide, cationized cellulose, and quaternization. A guar gum derivative etc. are mentioned as a suitable thing. Among these, a dimethyldiallylammonium chloride / acrylamide copolymer and the like are more preferable. (D) The weight average molecular weight of the cationic polymer compound is not particularly limited, but is usually preferably about 30,000 to 1,000,000.

  (D) More specifically, the cationic polymer compound is available from, for example, Merquat (registered trademark) (Mercoat) 100, Merquat 2200, Merquat 550, Merquat S, and Lion Corp., which are available from Calgon, USA. Cationized cellulose (Leogard (R) GP, Leogard KGP, Leogard MGP), Cationized guar gum (Jaguar (R) C-13S, Jaguar C-14S, Jaguar C-17S) available from Rhodia , Jaguar C-210, Jaguar C-1620) and the like. These cationic polymer compounds can be used singly or in appropriate combination of two or more.

  (D) The compounding quantity of a cationic polymer compound is not specifically limited, Usually, 0.1-1.0 mass% is preferable in a hair and scalp cleaning agent, More preferably, it is 0.5-0.8 mass%. It is. If it is less than 0.1% by mass, good rinsing properties, foam quality and foam amount may not be obtained, and if it exceeds 1.0% by mass, the finished feeling after drying may be lowered.

  (E) By mix | blending a silicone compound, the smoothness of the hair after drying is provided, it can improve as it is and hair loss can be prevented. The type of the silicone compound is not particularly limited, and those normally used for hair / scalp cleaning agents can be used. For example, dimethylpolysiloxane (including highly polymerized dimethylpolysiloxane and silicone rubber), methylphenylpolysiloxane, polyether modified silicone, amino modified silicone, betaine modified silicone, alcohol modified silicone, fluorine modified silicone, epoxy modified silicone, mercapto Modified silicone, carboxy-modified silicone, fatty acid-modified silicone, silicone graft polymer, cyclic silicone, alkyl-modified silicone, trimethylsilyl group-terminated dimethylpolysiloxane, silanol group-terminated dimethylpolysiloxane, and the like can be mentioned. Two or more species can be used in appropriate combination. Among these, dimethylpolysiloxane and amino-modified silicone are preferable from the viewpoint that the feel of hair after drying is better.

Moreover, as the silicone compound, not only oil, but also an emulsion obtained by emulsifying the silicone compound with a surfactant can be used. In addition, there is no restriction | limiting in particular in an emulsifier and the emulsification method, and such an emulsion can be used variously. Furthermore, dimethylpolysiloxane is preferably a mixture of the kinematic viscosity 1,000,000 mm ² / s or more high molecular weight silicone compound in 25 ° C., and kinematic viscosity 10,000 mm ² / s or lower viscosity silicone compound at 25 ° C. . The blending mass ratio of the high molecular weight silicone compound and the low viscosity silicone compound (high molecular weight silicone compound / low viscosity silicone compound) is preferably in the range of 1/99 to 60/40, and 5/95 to 40/60. A range is more preferred.

  (E) 0.01-10 mass% is preferable in a hair and scalp washing agent, and, as for the compounding quantity of a silicone compound, More preferably, it is 0.1-5 mass%. If it is less than 0.01% by mass, the effect of improving the feel of the hair after rinsing or after drying is insufficient, and if it exceeds 10% by mass, the hair after drying may become sticky and the hair feel may deteriorate. There is sex.

（式中、Ｒ¹²は炭素数８〜３２のアルキル基又はアルケニル基、平均重合度ｍは３〜２０を示す。）

（式中、Ｒ¹²は上記と同じ、Ｒ¹³及びＲ¹⁴はそれぞれ独立に水素原子又はメチル基、平均重合度ｎは１〜２０、平均重合度ｌは０〜２０を示す。）

（式中、Ｒ¹²は上記と同じ、Ｒ¹⁵及びＲ¹⁶はそれぞれ独立に水素原子、炭素数１〜４のアルキル基、又はフェニル基、Ｂは水酸基又は水素原子を示す。）

（式中、Ｒ¹²、Ｒ¹⁵及びＲ¹⁶は上記と同じ。）

（式中、Ｒ¹²、Ｒ¹⁵及びＲ¹⁶は上記と同じ。）

（式中、Ｒ¹²は上記と同じ。平均重合度ｒは１〜２０を示す。）

（式中、Ｒ¹³は上記と同じ。Ｒ¹⁷は炭素数３〜１８のアルキレン基又はアルケニレン基、Ｒ¹⁸は炭素数３〜１２のアルキル基又はアルケニル基を示す。平均重合度ｓ、ｔ及びｕはそれぞれ０〜４０であり、かつｓとｔとｕとの合計が５〜１００である。） By adding a nonionic surfactant and / or an amphoteric surfactant other than the above, it has a function of reducing irritation to the scalp and making it difficult to cause scalp roughness, and enhancing foaming, The performance as a hair cleaning agent can be improved. (F) As a nonionic surfactant and an amphoteric surfactant, what is represented by the following general formula (5)-(11) is mentioned, It is used individually by 1 type or in combination of 2 or more types as appropriate. it can.

(In the formula, R ¹² is an alkyl group or alkenyl group having 8 to 32 carbon atoms, and the average polymerization degree m is 3 to 20.)

(In the formula, R ¹² is the same as above, R ¹³ and R ¹⁴ are each independently a hydrogen atom or a methyl group, the average degree of polymerization n is 1 to 20, and the average degree of polymerization 1 is 0 to 20.)

(Wherein R ¹² is the same as above, R ¹⁵ and R ¹⁶ are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or a phenyl group, and B is a hydroxyl group or a hydrogen atom.)

(Wherein R ¹² , R ¹⁵ and R ¹⁶ are the same as above)

(Wherein R ¹² , R ¹⁵ and R ¹⁶ are the same as above)

(In the formula, R ¹² is the same as above. The average degree of polymerization r is 1 to 20.)

(Wherein, R ¹³ is the same .R ¹⁷ as the alkylene group or alkenylene group having 3 to 18 carbon atoms, R ¹⁸ is. An average polymerization degree of s, t and represents an alkyl group or an alkenyl group having 3 to 12 carbon atoms u is 0-40 respectively, and the sum of s, t, and u is 5-100.)

  (F) As for the compounding quantity of a nonionic surfactant and / or an amphoteric surfactant, 0.1-10 mass% is preferable in a hair and scalp washing | cleaning agent, More preferably, it is 1-7 mass%. If the amount is less than 0.1% by mass, the above-described effects of blending these may not be sufficiently obtained. If the amount exceeds 10% by mass, the viscosity of the hair / scalp cleaning agent is remarkably increased or decreased, and the solution stability deteriorates. There is a possibility.

  The pH of the hair / scalp cleaning agent of the present invention at 25 ° C. is in the range of 3.0 to 6.0. By being in this range, it is excellent in feeling of use and solution stability. As a pH adjuster, acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and hydrochloric acid, and alkalis such as triethanolamine, triisopropanolamine and potassium hydroxide can be optionally blended. Of these, particularly preferred are glycolic acid and citric acid for acids, and triethanolamine for alkali.

  In the hair / scalp cleaning agent of the present invention, in addition to the above-described components, water and other components used in normal hair / scalp cleaning agents can be blended within a range not impairing the effects of the present invention. As agents, lower alcohols such as ethanol and isopropanol, ethylene glycol, propylene glycol, glycerin, sorbitol, polyhydric alcohols such as polyethylene glycol other than the component (B), thickeners such as carboxymethylcellulose and hydroxyethylcellulose, Chelating agents such as acids and EDTA, opacifying agents such as ethylene glycol diisostearate and fish scales and mica pieces, pigments, antiseptic / antifungal agents and the like can be blended in appropriate amounts as necessary.

The hair / scalp cleaning agent of the present invention may contain a fragrance or a fragrance composition, and the fragrance and fragrance composition used are described in paragraphs [0021] to [0035] of JP-A-2003-300121. Perfume ingredients and perfume solvents described in paragraph [0050]. Although the usage-amount of the said solvent for fragrance | flavors can be mix | blended 0.1-99 mass% in a fragrance | flavor composition, Preferably it is 1-50 mass%. Moreover, examples of the perfume stabilizer include dibutylhydroxytoluene, butylhydroxyanisole, vitamin E and its derivatives, catechin compounds, flavonoid compounds, polyphenol compounds, and the like, and a preferable stabilizer is dibutylhydroxytoluene. These stabilizers can be blended in the fragrance composition in an amount of 0.0001 to 10% by mass, preferably 0.001 to 5% by mass.
In addition, the fragrance | flavor composition used for this invention is a mixture which consists of said fragrance | flavor component, a solvent, a fragrance | flavor stabilizer, etc. The fragrance composition is preferably added in an amount of 0.005 to 40% by mass, more preferably 0.01 to 10% by mass, based on the total amount of the hair / scalp cleaning agent.

  The hair / scalp cleaning agent of the present invention is produced by mixing and stirring each component according to a usual method. In this case, the component (A) can be easily produced by using an aqueous anionic surfactant solution having a concentration of 20 to 70% by mass previously diluted with purified water or ethanol. In addition, the (B) component, the (C) component and other components may be added as they are water-soluble or as an aqueous solution, or oil-soluble may be dissolved or dispersed in a fragrance or the like. Also good.

  The hair / scalp cleaning agent of the present invention has excellent foaming, detergency and bactericidal power, and promotes percutaneous absorption of the hair restoring active ingredient contained in the hair restoring agent used thereafter. Hair / scalp cleaning agent for promoting percutaneous absorption of the above-mentioned hair-growth active ingredient applied before using the hair-growth containing agent, applied to the hair / scalp before administration of the hair-growth containing the hair-growth active ingredient, A percutaneous absorption enhancer for promoting percutaneous absorption, which is suitable as a percutaneous absorption enhancer comprising a mixture of the above components (A), (B) and (C). In addition, by applying (cleaning) the scalp with this hair / scalp cleaner before using the hair restorer containing the hair restorer active ingredient, the percutaneous absorption of the hair restorer active ingredient can be promoted, and the hair restorer active ingredient is included. It is preferably used as a pre-care agent for hair restorer. After applying (cleaning) the scalp with a hair / scalp cleaning agent, the timing of using the hair-restoring agent containing the hair-growth active ingredient is not particularly limited, but is preferably about 3 hours after towel drying. Before towel drying, the hair restorer is diluted with the moisture contained in the hair, and the hair growth effect may be reduced. Over 3 hours after washing the hair, excess sebum on the scalp increases and the transdermal absorption effect decreases. there is a possibility.

  As the hair growth active ingredient, β-glycyrrhetinic acid, cephalanthin, assembly extract, hinokitiol, iodinated garlic extract, biotin, allantoin, pyridoxine hydrochloride, dl-α-tocopherol, dl-α-tocopherol acetate, trans-3,4'- Dimethyl-3-hydroxyflavanone, adenosine, minoxidil, pentadecanoic acid glyceride, 6-benzylaminopurine, nicotinic acid, nicotinic acid amide, calcium D-pantothenate, D-pantothenyl alcohol, acetyl pantothenyl ethyl ether, estradiol, ethinyl estradiol , Capronium chloride, diphenhydramine hydrochloride, photosensitizer 301, camphor, nonyl acid vanillyl amide, nonanoic acid vanillyl amide, mononitroguaiacol, γ-aminobutyric acid, a D extract, Ginkgo biloba extract, Ogon extract, Auxin, Hypericum extract, Seaweed extract, Cantalis tincture, Clara extract, Bovine hematin, Ginseng tincture, Duke extract, Dianthus extract, Cordyceps extract, Hydrocortisone, and A placenta extract etc. are mentioned, It can use individually by 1 type or in combination of 2 or more types. When these active ingredients are used in combination with the hair / scalp cleaning agent of the present invention, percutaneous absorption is promoted, and an improvement in hair growth effect can be expected.

  Examples of the action of these active ingredients include an anti-inflammatory action, peripheral vasodilation and / or blood flow promotion action, cell activation action, sebum secretion suppression action, and nutritional supplementation to hair matrix cells. Those having anti-inflammatory action include β-glycyrrhetinic acid, pyridoxine hydrochloride, and hydrocortisone. Those having peripheral vasodilation and / or blood flow promoting action include cephalanthin, garlic iodide extract, dl-α-tocopherol, dl-α-tocopherol acetate, capronium chloride, diphenhydramine hydrochloride, camphor, minoxidil, vanillylamide nonylate, Nonanoic acid vanillyl amide, mononitro guaiacol, and γ-aminobutyric acid may be mentioned. Examples of the cell activating activity include hinokitiol, biotin, allantoin, trans-3,4'-dimethyl-3-hydroxyflavanone, adenosine, 6-benzylaminopurine, and photosensitizer 301. Examples of those having an effect of supplying nutrition to hair matrix cells include pentadecanoic acid glyceride, nicotinamide, and nicotinic acid. Examples of those having a sebum secretion inhibitory action include estradiol and ethinyl estradiol. In addition, as an active ingredient that has been reported to have a hair-growth effect, plant extracts such as assembly extract, aloe extract, ginkgo biloba extract, longhorn extract, auxin, hypericum extract, seaweed extract, cantalis tincture, and clara extract , Ginseng tincture, Duke extract, Dendrobium extract, Cordyceps extract, bovine hematin, placenta extract, animal extract, calcium D-pantothenate, D-pantothenyl alcohol, acetyl pantothenyl Ethyl ether is mentioned.

  Among these, preferable active ingredients that improve the hair-growth effect by percutaneous absorption are effective in having peripheral vasodilation and / or blood flow promotion action, cell activation action, sebum secretion inhibition action, and nutritional supplementation to hair matrix cells. Ingredients and vitamins, more preferably those having an active ingredient having peripheral vasodilation and / or blood flow promoting action, cell activation action, nutritional supply to hair matrix cells, particularly dl-α-tocopherol Dl-α-tocopherol acetate, capronium chloride, minoxidil, adenosine, 6-benzylaminopurine, pentadecanoic acid glyceride, calcium D-pantothenate, and D-pantothenyl alcohol.

  In addition to the hair-growth active ingredient, ingredients normally contained in the hair-growth agent may be blended in the hair-growth agent. The hair restorer containing a hair-growth active ingredient may be a commercially available or known hair-growth agent, and the agent system of the hair-growth agent to be used is not particularly limited, but is liquid, tonic, spray, shower, cream, mousse And a sheet shape impregnated with a liquid agent.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In addition, all% in each example is the mass%, and is a pure content conversion value (AI) of each component.

[Preparation Example]
Preparation of polyoxyethylene alkyl (C12,13) ether sulfate sodium sulfate (2EO) Into a 4 L autoclave was charged 400 g of lauryl alcohol and 0.4 g of a composite metal oxide Lewis acid sintered solid catalyst composed of Al / Mg / Mn. The autoclave was purged with nitrogen, and the temperature was raised while stirring. Thereafter, 54 g of ethylene oxide was introduced while maintaining a temperature of 180 ° C. and a pressure of 0.3 mPa to obtain a reaction product. Next, 274 g of the alcohol ethoxylate thus obtained was placed in a 500 mL flask equipped with a stirrer, and after substitution with nitrogen, 81 g of liquid sulfuric anhydride (sulfan) was slowly added dropwise while maintaining the reaction temperature at 40 ° C. After completion of the dropwise addition, stirring was continued for 1 hour to obtain the target sodium polyoxyethylene (C12,13) ether sulfate (2EO).

[Examples 1-16, Comparative Examples 1-5]
The hair and scalp cleaning agents having the compositions shown in 1 to 3 were prepared according to a conventional method, and the percutaneous absorption promotion rate and viable bacteria suppression were measured by the following methods to evaluate the good foaming and good soil removal. The results are also shown in the table.

[Percutaneous absorption promotion rate]
Pre-sheared guinea pig (HARTLEY female, female) dorsal exfoliated skin (5cm x 5cm) into Franz diffusion cell (diffusion effective membrane area approx. 4cm ² ), stratum corneum side on donor phase side (top), dermis side on receptor The scissors were fixed so as to be on the phase side (bottom).
Subsequently, the treatment was performed according to the following procedure assuming the time of washing the hair. First, 1 mL of a solution obtained by diluting the scalp / hair washing agent 15 times (mass) with tap water at 40 ° C. was added to the donor phase of the Franz diffusion cell and allowed to act for 1 minute while foaming with a dropper. Thereafter, it was rinsed with tap water at 40 ° C. at a rate of 2 L / min for 1 minute, and then a drier was applied to the stratum corneum skin surface on the donor phase side of the Franz diffusion cell for 1 minute. On the other hand, as a control, 1 mL of 40 ° C. tap water not containing the scalp / hair washing agent was added to the donor phase of the Franz diffusion cell and stirred with a dropper for 1 minute. Thereafter, tap water at 40 ° C. was rinsed at a rate of 2 L / min for 1 minute, and a dryer was applied to the stratum corneum skin surface on the donor phase side of the Franz diffusion cell for 1 minute.

  The receptor phase was filled with physiological saline and kept at 32 ° C. in a constant temperature layer with stirring. After leaving for 1 hour, 50 μL of a hair-growing agent (sales name: hair force (registered trademark) Da, manufactured by Lion Corporation) was added on the donor phase (keratin layer). 24 hours after the addition, physiological saline in the receptor phase was sampled, and the amount of 6-benzylaminopurine in the receptor phase was measured by quantifying the hair-growth active ingredient 6-benzylaminopurine by HPLC. Table 1 shows the relative value (%) when the permeation amount when treated with only control water is 100%.

HPLC condition detector: ultraviolet absorptiometer (measurement wavelength: 230-280 nm)
Column: Inertsil ODS-2 (φ4.6 × 150 mm, manufactured by GL Sciences Inc.)
Column temperature: 40 ° C
Mobile phase: methanol / water

[Live bacteria suppression]
Each viable count was measured by the following method.
After shaving the hair of the temporal region of three male panelists at about 1.5 cm x 1.5 cm square on both the left and right sides, the scalp and hair cleanser were diluted 15 times (mass) with 40 ° C tap water. The hair was washed with 0.5 mL of the solution. The hair was dried with a dryer and allowed to rest for 30 minutes. Thereafter, a glass tube having a diameter of 10 mm and a height of about 20 mm was pressed against the shaved portion, and 0.1 mass% Tween 80 (polyoleic acid poly (polyoleate)) was formed from the scalp circular portion surrounded by the inner periphery of the glass tube in contact with the shaved portion. Bacteria were collected using a sterile cotton swab dipped in physiological saline containing oxyethylene (20) sorbitan). The collected cotton swab is put into a test tube into which 2 mL of 0.1 mass% Tween 80-containing physiological saline is injected, and stirred for 1 minute using a vortex mixer (manufactured by Tokyo Rika Kikai Co., Ltd., IMS-1000 type). A fungus dispersion was prepared. 100 μL of each bacterial dilution obtained by diluting the bacterial dispersion was taken into an SCDLP agar medium, the number of colonies after 24 hr culture at 37 ° C. was counted, and the number of viable bacteria was calculated from the following formula.
Viable count (cfu / cm ² ) = number of colonies × dilution ratio × 20 / 0.5 / 0.5 / π
Further, 6 hours after washing the hair, the bacteria of the scalp were collected by the same method and the viable cell count was measured.

From the average value of the logarithm of the number of viable cells 30 minutes and 6 hours after washing the hair of three male panelists, viable cell suppression was evaluated based on the following formula.
(Average value of logarithmic value of viable cell count after 6 hours)-(Average value of logarithmic value of viable cell count after 30 minutes)
The evaluation was evaluated as “x” when the numerical value obtained by the above formula exceeds 1, “◯” when greater than 0.5 and 1 or less, and “◎” when 0.5 or less.

[Good foaming and good dirt removal]
Actual use evaluation was performed on 10 men in their 30s to 50s who normally use hair restorers. Evaluation items were evaluated with respect to good foaming and good soil removal when the corresponding product was washed once a day, and the following evaluation criteria were shown in the table.
<Evaluation criteria>
◎: 9 or more out of 10 respondents: ○: 6-8 out of 10 respondents △: 3-5 out of 10 respondents: X: Good Less than 3 out of 10

実施例の香料は下記のものを使用した。
香料Ａ：特願２００４−２９４８４８号 表５〜１９に記載の香料Ａ
香料Ｂ：特願２００４−２９４８４８号 表５〜１９に記載の香料Ｂ
香料Ｃ：特願２００４−２９４８４８号 表５〜１９に記載の香料Ｃ
香料Ｄ：特願２００４−２９４８４８号 表５〜１９に記載の香料Ｄ The components used in Examples and Comparative Examples are shown in the following table.

The following fragrances were used.
Perfume A: Japanese Patent Application No. 2004-294848 Perfume A described in Tables 5-19
Perfume B: Japanese Patent Application No. 2004-294848 Perfume B described in Tables 5-19
Perfume C: Japanese Patent Application No. 2004-294848 Perfume C described in Tables 5-19
Perfume D: Japanese Patent Application No. 2004-294848 Perfume D described in Tables 5-19

Claims (6)

  A hair / scalp cleanser containing (A) an anionic surfactant, (B) a transdermal absorption promoting substance, and (C) a bactericidal component. The component (A) is a polyoxyalkylene alkyl ether sulfate, the component (B) is a polyalkylene glycol that is liquid at room temperature, a cationic surfactant represented by the following general formula (1) and / or the following general formula ( The hair / scalp cleaning agent according to claim 1, comprising an amine oxide represented by 2), wherein the component (C) is an aromatic carboxylic acid represented by the following general formula (4) and / or a salt thereof.

Wherein R ¹ is a saturated or unsaturated monovalent hydrocarbon group having 8 to 32 carbon atoms, R ² is a saturated or unsaturated monovalent hydrocarbon group having 1 to 32 carbon atoms, and R ³ is 1 carbon atom. 6 alkyl group, or a phenyl group, R ⁴ represents an alkyl group, or a hydrogen atom having 1 to 6 carbon atoms .X ^- is ^{Cl -, Br -, I -} , CH 3 OSO 3 -, or C ₂ H ₅ OSO ₃ ^- show a).

[Wherein, R ⁵ is a saturated or unsaturated monovalent hydrocarbon group having 8 to 32 carbon atoms, R ⁶ and R ⁷ are each independently a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a hydroxyalkyl group, or The following structural formula (3)

(Wherein R ⁸ represents a hydrogen atom, a methyl group or an ethyl group, and q represents an integer of 1 to 3)
The monovalent substituent represented by these is shown. p represents 0 or an integer of 5 or less. ]

(In the formula, R ⁹ , R ¹⁰ and R ¹¹ each independently represents an alkyl group having 1 to 3 carbon atoms, a hydroxyl group or a hydrogen atom, and A represents a carboxyl group or a salt thereof.)   The hair / scalp cleaning composition according to claim 1 or 2, which is applied before use of a hair restorer containing an active ingredient for hair restorer and for promoting percutaneous absorption of the active ingredient for hair restorer.   A method for promoting percutaneous absorption of an active ingredient for hair restorer, wherein the scalp is washed with the hair / scalp detergent composition according to claim 1 before using the hair restorer containing an active ingredient for hair restorer.   Hair growth active ingredients are β-glycyrrhetinic acid, cephalanthin, assembly extract, hinokitiol, iodinated garlic extract, biotin, allantoin, pyridoxine hydrochloride, dl-α-tocopherol, dl-α-tocopherol acetate, trans-3,4'- Dimethyl-3-hydroxyflavanone, adenosine, minoxidil, pentadecanoic acid glyceride, 6-benzylaminopurine, nicotinic acid, nicotinic acid amide, calcium D-pantothenate, D-pantothenyl alcohol, acetyl pantothenyl ethyl ether, estradiol, ethinyl estradiol , Capronium chloride, diphenhydramine hydrochloride, photosensitizer 301, camphor, nonyl acid vanillylamide, nonanoic acid vanillylamide, mononitroguaiacol, γ-aminobutyric acid, aloe Extract, Ginkgo biloba extract, Ogon extract, Auxin, Hypericum extract, Seaweed extract, Cantalis tincture, Clara extract, Bovine hematin, Ginseng tincture, Duke extract, Dianthus extract, Cordyceps extract, Hydrocortisone, and Placenta The method for promoting percutaneous absorption according to claim 4, which is one or more components selected from the group consisting of extracts. A percutaneous absorption enhancer which is applied to hair and scalp before administration of a hair restorer containing a hair restorer active ingredient and promotes transdermal absorption of the hair restorer active ingredient, and includes the following (A), (B1), (B2 ) And (C).
(A) Polyoxyalkylene alkyl ether sulfate (B1) Polyalkylene glycol that is liquid at room temperature (B2) Cationic surfactant represented by the following general formula (1) and / or the following general formula (2) Amine oxide (C) Aromatic carboxylic acid represented by the following general formula (4) and / or salt thereof

Wherein R ¹ is a saturated or unsaturated monovalent hydrocarbon group having 8 to 32 carbon atoms, R ² is a saturated or unsaturated monovalent hydrocarbon group having 1 to 32 carbon atoms, and R ³ is 1 carbon atom. 6 alkyl group, or a phenyl group, R ⁴ represents an alkyl group, or a hydrogen atom having 1 to 6 carbon atoms .X ^- is ^{Cl -, Br -, I -} , CH 3 OSO 3 -, or C ₂ H ₅ OSO ₃ ^- show a).

[Wherein, R ⁵ is a saturated or unsaturated monovalent hydrocarbon group having 8 to 32 carbon atoms, R ⁶ and R ⁷ are each independently a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a hydroxyalkyl group, or The following structural formula (3)

(Wherein R ⁸ represents a hydrogen atom, a methyl group or an ethyl group, and q represents an integer of 1 to 3)
The monovalent substituent represented by these is shown. p represents 0 or an integer of 5 or less. ]

(In the formula, R ⁹ , R ¹⁰ and R ¹¹ each independently represents an alkyl group having 1 to 3 carbon atoms, a hydroxyl group or a hydrogen atom, and A represents a carboxyl group or a salt thereof.)