CN109528523A - A kind of amino acid cleansing cream - Google Patents

A kind of amino acid cleansing cream Download PDF

Info

Publication number
CN109528523A
CN109528523A CN201811631492.9A CN201811631492A CN109528523A CN 109528523 A CN109528523 A CN 109528523A CN 201811631492 A CN201811631492 A CN 201811631492A CN 109528523 A CN109528523 A CN 109528523A
Authority
CN
China
Prior art keywords
amino acid
skin
sodium
cleansing cream
acid cleansing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201811631492.9A
Other languages
Chinese (zh)
Other versions
CN109528523B (en
Inventor
王丽辉
董明生
彭瑜瑜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Kousai Biotechnology Co Ltd
Original Assignee
Guangzhou Kousai Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Kousai Biotechnology Co Ltd filed Critical Guangzhou Kousai Biotechnology Co Ltd
Priority to CN201811631492.9A priority Critical patent/CN109528523B/en
Publication of CN109528523A publication Critical patent/CN109528523A/en
Application granted granted Critical
Publication of CN109528523B publication Critical patent/CN109528523B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85Polyesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9722Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)

Abstract

The invention discloses a kind of amino acid cleansing creams, it includes amino acid surfactant and skin conditioning agent, the skin conditioning agent includes Sodium Hyaluronate, shale oil sulphonic acid ester sodium, Codium Tomentosum extract, polyquaternium -51, decoyl glycine and soapberry fruit extract.Amino acid cleansing cream of the invention has excellent dirt-removing power, face can be effectively cleaned, foaming abundancy is fine and smooth, salubrious not tight after, also has effects that skin repair, there is good inhibiting effect to the bacterium for causing skin problem, can anti-acne, anti-acne print, pore refining and adjust skin water and oil balance, get well state conducive to skin, without preservative, mild pro-skin, highly-safe, pregnant woman and sensitive flesh person can be used.

Description

A kind of amino acid cleansing cream
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of amino acid cleansing creams.
Background technique
Mildy wash is also known as facial cleanser, is the dedicated cosmetics of face as the main purpose with cleaning skin, and decontamination mechanism is The surface tension that dirt is reduced using surfactant removes dirt by the effects of wetting, dispersion, foaming, emulsification.City at present Mildy wash on face can be divided into two class of soap base type and non-soap fundamental mode.Soap base type contains fatty acid soaps ingredient, and foaming abundancy is easy to rush It washes, but product slightly stimulates, washing rear skin has tight feeling.And non-soap base type product has soapy feeling after washing, because the surface of compounding is living Property agent it is different, foaming power, cleaning strength and irritation are all different, if any non-soap basic product in order to improve foaming power, clean Power and cost is reduced, the alkalinity such as lauryl sodium sulfate can be added compared with strong, the biggish surfactant of irritation, if being used for a long time This kind of product can destroy sebum film, and skin is highly susceptible to external injury.In recent years, with advances in technology with people to environmental protection The attention of problem and own health problem, amino acid surfactant are gradually found and apply.Amino acid surfactant It is biology base natural origin amino acid derivativges, biological degradability is good, Product Green, safe, mild, low stimulation, with skin There is good compatibility, there is excellent surface-active, application field is also more and more extensive.
Although these products added with chemical preservative etc. due to stimulating currently, having amino acids mildy wash on the market Property ingredient, to destroy the safe mildness of amino acid surfactant itself to a certain extent.Meanwhile these products are universal There are problems that having a single function, the raising with consumer to the functional requirement of mildy wash, a good face cleaning product, in addition to answering Have except decontamination, the safely basic functions such as mild, should also have the skin-protecting function of other aspects.
Summary of the invention
It is an object of the invention to solve above-mentioned shortcoming and defect existing in the prior art, a kind of amino acid cleansing is provided Cream.Not only face cleaning effect is good, environmentally friendly, safe, non-stimulated for the amino acid cleansing cream, also has anti-acne, anti-acne print, pore refining And the skin-care effects such as water and oil balance are adjusted, and be free of preservative.
To realize its purpose, the technical scheme adopted by the invention is as follows:
A kind of amino acid cleansing cream, it includes amino acid surfactant and skin conditioning agent, the skin conditioning agent packet Sodium Hyaluronate, shale oil sulphonic acid ester sodium, Codium Tomentosum extract, polyquaternium -51, decoyl glycine and soapberry fruit is included to mention Take object.
Further, the skin conditioning agent includes that Sodium Hyaluronate, shale oil sulphonic acid ester sodium, Codium Tomentosum extract are molten Liquid, -51 solution of polyquaternium, decoyl glycine and soapberry fruit extract solution.
The Sodium Hyaluronate that the present invention uses is oligomerization Sodium Hyaluronate, and trade name " nano HA " is purchased from " Hua Xi Fu Ruida biological medicine Co., Ltd ".Its mean molecule size is less than 25nm, can promote Transdermal absorption, no cytotoxicity, safety Property it is high, there is good water-retaining property, moreover it is possible to promote new vessels generation, cell Proliferation, wound repair, dermal photodamage reparation and Radicals scavenging.
Shale oil sulphonic acid ester sodium has special effect to careful pore, anti-acne, anti-acne print, acne of dispelling and anti-inflammatory anti-itch.The present invention makes The trade name " ICHTHYOL-PALE " of shale oil sulphonic acid ester sodium, is purchased from " German Ichthyol-Gesellschaft Company ".
Entitled " water (and) butanediol (and) the fur pine algae of the standard Chinese of the Codium Tomentosum extract solution (CODIUM TOMENTOSUM) extract ", trade name "BG/PF Codium Tomentosum extract ", It is purchased from " France's match BIC Corp (SEPPIC) ".Codium Tomentosum extract in the Codium Tomentosum extract solution is rich in dimension Life element and phenols, there is the effect of sterilization moisturizing, and instant and lasting aquation can be carried out for skin tape.
The standard Chinese of -51 solution of polyquaternium is entitled " polyquaternium -51, water ", trade name "- PMB " is purchased from " Japan Oil Co ".Polyquaternium -51: hyaluronic acid is 1. compared, moisture retention is more It is excellent;2. the skin irritation of classes of compounds can be mitigated;3. there is excellent biocompatibility, it is highly-safe.
Decoyl glycine can inhibit the breeding for causing the bacterium of acne, to have effects that anti-acne;Suppression can also be passed through 5- alpha-reductase processed inhibits sebum secretion, is a kind of Derma-Guard, cutaneous ecosystem regulator.
The standard Chinese of the soapberry fruit extract solution is entitled, and " soapberry (SAPINDUS MUKUROSSI) fruit mentions Take object, glycerol ", trade name " Soapberry Extract " is purchased from " BIOLAND company ".Soapberry fruit extract has It inhibits tyrosinase activity, remove free radical and antibacterial and other effects.
Skin conditioning agent of the present invention is compounded by the component of 6 kinds of different efficacies characteristics, is respectively played between component It also complements each other while effect.Wherein, Sodium Hyaluronate, Codium Tomentosum extract and the parent having the same of polyquaternium -51 Aqueous and water imbibition, when three compounds, skin permeability is strong, can promote the synthesis of skin lipid, improves the barrier function of skin, And absorption and moisture-keeping functions to moisture around.Shale oil sulphonic acid ester sodium, decoyl glycine and soapberry fruit extract three Compounding has Controlling oil effect, can inhibit the breeding of bacterium, to clean, conditioning skin, improve the antibiotic property of skin.The skin The overall percutaneous absorbability of skin conditioner is good, and mildness is higher, can promote skin hydration, improves skin water content, and to skin Skin is repaired, and quick anti-acne acne, anti-acne print and pore refining adjust skin water and oil balance, skin made to get well.
Preferably, weight percentage of the component of the skin conditioning agent in the amino acid cleansing cream are as follows: transparent Matter acid sodium 0.01%~0.3%, shale oil sulphonic acid ester sodium 0.001%~0.2%, Codium Tomentosum extract solution 0.01%~ 1%, -51 solution 0.01%~1% of polyquaternium, decoyl glycine 0.1%~2% and soapberry fruit extract solution 1%~ 20%.Additive amount of the component of the skin conditioning agent in amino acid cleansing cream within the above range when, the skin Synthesis of conditioner in terms of promoting skin hydration, eliminating small pox and acne print, pore refining and adjusting skin Effect is more preferable.
It is highly preferred that weight percentage of the component of the skin conditioning agent in the amino acid cleansing cream are as follows: thoroughly Bright matter acid sodium 0.05%, shale oil sulphonic acid ester sodium 0.01%, Codium Tomentosum extract solution 0.05%, -51 solution of polyquaternium 0.05%, decoyl glycine 1% and soapberry fruit extract solution 10%.The skin conditioning agent is applied to institute with above-mentioned formula It is most obvious to the repairing effect of skin when stating in amino acid cleansing cream.
Preferably, the amino acid surfactant includes sodium lauroyl glutamate and sodium cocoyl glycinate.
Sodium lauroyl glutamate not only has good readily degradable, antibiotic property, a safety and without anaphylaxis, but also due to Its special structure determine its as amphoteric surfactant with good water solubility, salt-resistance is strong and has pH responsiveness etc. Many excellent properties.Meanwhile sodium lauroyl glutamate has hydrophily and lipophilicity, can quickly remove the greasy dirt on skin, Control action is played to skin oil and fat, helps absorption of the skin to nutritional ingredient.
Sodium cocoyl glycinate is extracted in glycine and plant in the main component amino acid of human skin collagen Amino acid surfactant caused by coco-nut oil fatty acid.It can make the foam of mildy wash smooth rich in elastic force, make skin Clearly without tight after use.
Preferably, weight percentage of the component of the amino acid surfactant in the amino acid cleansing cream Are as follows: sodium lauroyl glutamate 10%~40% and sodium cocoyl glycinate 2%~20%.Sodium lauroyl glutamate and cocounut oil acyl are sweet When propylhomoserin sodium is compounded with above-mentioned additive amount, there is preferable decontamination, effective cleaning can be played the role of to face, foam is rich It is rich fine and smooth and good with rear skin sense.
It is highly preferred that the weight ratio of the sodium lauroyl glutamate and sodium cocoyl glycinate are as follows: lauroyl glutamate Sodium: sodium cocoyl glycinate=6:1.When sodium lauroyl glutamate and sodium cocoyl glycinate are with proportion compounding, to skin Cleaning effect and all best with rear skin sense, and the absorption of other functional components can be advantageously promoted.
Preferably, weight percentage, the amino acid cleansing cream also include 10%~35% He of 1,3-PD Glycine betaine 0.1%~3%.
Glycine betaine is a kind of natural amino acid moisturizer, with very strong moisture absorbing, and hydrone can be allowed by skin Skin cell is absorbed and utilized, and can reinforce skin barrier layer, slows down the loss of moisture of skin, increases the moisture holding capacity of skin, while can also Stimulating component is reduced to the stimulation of skin.Additive amount of the glycine betaine in the amino acid cleansing cream is above range When, the moisture holding capacity of skin can be effectively increased.
Preferably, the amino acid cleansing cream also includes Sensiva SC50.Sensiva SC50 is in inventive formulation It can be used as emollient, improve the moisturizing effect of mildy wash.Meanwhile Sensiva SC50 is in inventive formulation or a kind of more function Energy additive, on the one hand, its fragrance that can enhance flavors and fragrances, and fixation and steady fragrant efficiency are played, prior one side, It can in inventive formulation decoyl glycine and soapberry fruit extract solution antibiosis generate synergistic function, To play excellent preservative efficacy, make the amino acid cleansing cream without adding preservative, safety is higher, and property is warmer With.In addition, Sensiva SC50 can also improve the thixotropy of face cleaning product.
Preferably, weight percentage of the Sensiva SC50 in amino acid cleansing cream be 0.05%~ 0.3%.Additive amount of the Sensiva SC50 in amino acid cleansing cream within the above range when, with decoyl glycine and nothing The synergistic function for suffering from sub- berry extract solution becomes apparent from, and the antisepsis of performance is more preferable.
It is highly preferred that weight percentage of the Sensiva SC50 in the amino acid cleansing cream is 0.1%.Second When additive amount of the base hexyl glycerol in the amino acid cleansing cream is above-mentioned value, with decoyl glycine and soapberry fruit extract The synergistic function of solution is most obvious, and the antisepsis of performance is best.
Preferably, weight percentage, the amino acid cleansing cream also include chelating agent 0.02%~0.2%, increase Thick dose 0.1%~1% and thickening suspending agent 1%~5%.
Preferably, the chelating agent is EDETATE SODIUM.
Preferably, the thickener is PEG-150 distearate.
Preferably, the thickening suspending agent is acrylic acid (ester) analog copolymer.
The present invention also provides a kind of amino acid cleansing creams, are grouped as by the group of following weight percentage: lauroyl Sodium glutamate 10%~40%, sodium cocoyl glycinate 2%~20%, Sodium Hyaluronate 0.01%~0.3%, shale oil sulfonic acid Ester sodium 0.001%~0.2%, Codium Tomentosum extract solution 0.01%~1%, -51 solution 0.01%~1% of polyquaternium, Decoyl glycine 0.1%~2%, soapberry fruit extract solution 1%~20%, 1,3- propylene glycol 10%~35%, glycine betaine 0.1%~3%, Sensiva SC50 0.05%~0.3%, EDETATE SODIUM 0.02%~0.2%, PEG-150 distearate 0.1%~1%, acrylic acid (ester) analog copolymer 1%~5%, essence 0.01%~0.5% and water surplus.
Compared with prior art, the beneficial effects of the present invention are: amino acid cleansing creams of the invention to have excellent go Dirty ability, can effectively clean face, and foaming abundancy is fine and smooth, salubrious not tight after, also have effects that skin repair, to causing skin The bacterium of skin problem has good inhibiting effect, and energy anti-acne, anti-acne print, pore refining and adjusting skin water and oil balance are conducive to Skin is got well state, and preservative is free of, and mild pro-skin is highly-safe, and pregnant woman and sensitive flesh person can be used.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, the present invention passes through the following example furtherly It is bright.It should be understood that the embodiment of the present invention is merely to illustrate technical effect of the invention, protection model and is not intended to limit the present invention It encloses.In embodiment, method therefor is conventional method unless otherwise instructed.
Embodiment
Examples 1 to 9 is the embodiment of amino acid cleansing cream of the present invention, the cream of amino acid cleansing described in Examples 1 to 9 Formula it is as shown in table 1.
In embodiment: Sodium Hyaluronate is oligomerization Sodium Hyaluronate, trade name " nano HA ", purchased from " the prosperous Fu Ruida of China Biological medicine Co., Ltd ".Entitled " water (and) butanediol (and) the fur pine algae of the standard Chinese of Codium Tomentosum extract solution (CODIUM TOMENTOSUM) extract ", trade name "BG/PF Codium Tomentosum extract ", purchase From " France's match BIC Corp (SEPPIC) ".The standard Chinese of -51 solution of polyquaternium is entitled " polyquaternium -51, water ", quotient The name of an article be "- PMB " is purchased from " Japan Oil Co ".The standard Chinese of soapberry fruit extract solution is entitled " soapberry (SAPINDUS MUKUROSSI) berry extract, glycerol ", trade name " Soapberry Extract " is purchased from " BIOLAND company ".
Examples 1 to 9 amino acid cleansing cream the preparation method comprises the following steps: by water, EDETATE SODIUM, 1,3- propylene glycol and lauroyl Sodium glutamate sequentially adds in pot, heating stirring, until dissolution is complete;Then PEG-150 distearate and glycine betaine is added, stirs (30~50Hz) is mixed to being completely dissolved, 80~85 DEG C of insulated and stirred 30min;Then water-dispersible good acrylic acid in advance is added (ester) analog copolymer and sodium cocoyl glycinate and Sodium Hyaluronate, stir evenly (40~50Hz), then cool down;Temperature Be down to 45~50 DEG C close on knot paste state when, reduce mixing speed (10~15Hz);When temperature is down to 40~42 DEG C, sequentially add Shale oil sulphonic acid ester sodium, Codium Tomentosum extract solution, -51 solution of polyquaternium, decoyl glycine, soapberry fruit extract are molten Liquid, Sensiva SC50 and essence stir 30min, are sufficiently mixed material uniformly, after sampling Detection is qualified, at 38~40 DEG C The amino acid cleansing cream is made in filtering and discharging.
The formula of amino acid cleansing cream described in 1 Examples 1 to 9 of table
One, safety evaluatio
(1) testing in vitro
By amino acid cleansing product (product A and the product of the amino acid cleansing cream of Examples 1 to 9 and two commercially available purchase B it) is diluted to 10% active matter content respectively, with chick chorioallantoic membrane (HET-CAM) Eye irritation alternate test, the stimulation of test product Property.
Test philosophy: CAM is the fertilization chicken embryo mid-term chorioallantoic membrane for hatching 10~14 days embryo ages, this experiment utilizes CAM Complete, the clear and transparent feature of vascular system, a certain amount of tested material is directly contacted with CAM, and effect is seen after a period of time CAM injury of blood vessel is examined, is scored different injury of blood vessel degree, injury of blood vessel is more serious, and score value is bigger.This method is special Emphasize the vascular effect of detectable substance, such as thus cause ghost blood vessel, capillary injection/capillary hemorrhage phenomena such as, survey The distribution of existing and its score value take temperature as shown in table 3, test result is as shown in table 4.
Table 3
Table 4
Test product Testing in vitro (NC value)
Embodiment 1 0.28
Embodiment 2 0.375
Embodiment 3 0.25
Embodiment 4 0.125
Embodiment 5 0.415
Embodiment 6 0.375
Embodiment 7 0.27
Embodiment 8 1.25
Embodiment 9 1.375
Product A 2.75
Product B 2.50
(2) patch test
By amino acid cleansing product (product A and the product of the amino acid cleansing cream of Examples 1 to 9 and two commercially available purchase B it) is diluted to 10% active matter content respectively.Volunteer of 55 ages at 20~40 years old is selected, is divided into 11 groups, every group at random 5 people carry out patch test using Examples 1 to 9 and two commercial product respectively.
Test method: 1cm is used respectively24 thickness gauzes of size soak the good test solution of above-mentioned dilution, the yarn that then will be soaked The forearm that cloth spreads on volunteer bends side, is covered thereon with slightly larger cellophane cover, and surrounding is fixed with adhesive plaster, and yarn is removed after 48h Cloth, and according to the performance interpretation result of local skin.Test result is feminine gender, then without allergic phenomena;Test result is the positive, then Generate irritative response (erythematous response disappears quickly after irritative response removal spot examination object) or allergic reaction (allergic reaction Then show as wellability erythema, papule etc.).Test result is as shown in table 5.
Table 5
Test product Patch test (negative number)
Embodiment 1 10
Embodiment 2 10
Embodiment 3 10
Embodiment 4 10
Embodiment 5 10
Embodiment 6 10
Embodiment 7 10
Embodiment 8 10
Embodiment 9 10
Product A 7
Product B 6
The test result of above-mentioned table 4 and table 5 shows: the amino acid cleansing cream of the embodiment of the present invention is mild nonirritant, makes With safety.
Two, face cleaning effect assessment
Respectively with the amino acid cleansing cream of Examples 1 to 9 and the amino acid cleansing product of two commercially available purchase (product A and Product B) it is used as test sample, carry out face cleaning measure of merit.
Volunteer of 110 ages at 20~40 years old is selected, volunteer is divided into 11 groups at random, every group of 10 people distinguish It is evaluated using above-mentioned test sample, and to its face cleaning effect.
Evaluation criterion is as shown in table 6, and evaluation result is as shown in table 7.
6 face cleaning effect assessment standard of table
Cleaning effect Moistening effect
Satisfied: cleaning dynamics is preferable It is satisfied: entirely without tight feeling after washing
Satisfied: cleaning dynamics is good It is satisfied: without obvious tight feeling after washing
General: cleaning dynamics is fine It is general: it is somewhat dry to wash rear skin
Difference: cleaning force is poor Difference: washing rear skin has obvious tight feeling
7 evaluation result of table
The evaluation result of table 7 shows that the amino acid cleansing cream of the embodiment of the present invention has preferable skin cleaning effect and use Skin sense afterwards, moisture retention is good, not tight after.
Comparing embodiment 1~3 is it is found that sodium lauroyl glutamate: when sodium cocoyl glycinate=6:1, amino acid cleansing cream Cleaning effect and all best with rear skin sense.
Three, to probe into the formula of the skin conditioning agent to the shadow of adjusting water and oil balance effect of the amino acid cleansing cream It rings, therefore the test group of table 2 is set.
The skin conditioning agent is added by the proportion in table 2, remaining component and preparation method matching according to embodiment 1 Side.
2 skin conditioning agent of table
Component (%) Test group 1 Test group 2 Test group 3
Sodium Hyaluronate 0 0.1 1.05
Shale oil sulphonic acid ester sodium 0 0.06 0.01
Codium Tomentosum extract solution 0.1 0 0
- 51 solution of polyquaternium 0.06 0 0.1
Decoyl glycine 1 1 0
Soapberry fruit extract solution 10 10 10
Respectively with the amino acid cleansing cream of embodiment 1, embodiment 8, embodiment 9 and test group 1~3 and two commercially available purchase The amino acid cleansing product (product A and product B) bought is used as test sample, tests its effect for adjusting skin water and oil balance.
Choose oily skin volunteer of 80 ages at 18~35 years old.80 volunteers are divided into 8 groups, every group 10 People.When being unified in morning 9, test sample cleaning face is used.
The test method of skin oil and fat secretory volume: respectively at the grease of at 1 point at noon and at 5 points in afternoon with finger detection nose Amount.
The test method of skin moisture content: it respectively at using before test sample and using 1h after test sample, is visited with more The water content of head skinanalysis apparatus MPA4 test skin, retest 3 times, takes mean value.
Test result such as table 8 and table 9.
8 skin oil and fat of table secretes situation
9 moisture content of skin of table
It can be seen that from the data of table 8 and table 9, the mildy wash of the embodiment of the present invention 1, embodiment 8 and embodiment 9 can be effective Control skin oil and fat secretion, moreover it is possible to improve the moisture content of skin, and significant effect is produced better than commercially available two amino acid cleansing Product, it is especially best with the effect of embodiment 1.
The effect of comparing embodiment 1 and test group 1~3 is it is found that in the case where same additive amount, the skin conditioning agent In when lacking constituent part, the effect that mildy wash adjusts skin water and oil balance can be greatly affected, and also illustrate, the skin conditioning agent Each component between have mutual synergistic effect, keep effect of the skin conditioning agent in terms of adjusting skin water and oil balance more aobvious It writes.
Four, preservation challenge
Using the facial cleanser of Examples 1 to 9 as given the test agent, preservation challenge test is carried out, test result is as shown in table 10.
It can be seen that from the structure of table 10, the facial cleanser of the embodiment of the present invention all has preferable anti-corrosion effect, test process In it has also been found that, the antibiotic property of embodiment 1 is best, illustrates that its anti-corrosive properties is best.It can be seen that the amino acid of inventive formulation is washed one's face Milk is also able to satisfy the requirement for anticorrosion of cosmetics without preservative.
10 preservation challenge result of table
In preservation challenge test:
Mixed cell includes Escherichia coli, staphylococcus aureus, Bacillus subtilis endophyticus, bacillus subtilis The common bacterium such as bacterium, Pseudomonas fluorescence and onion Pseudomonas alba.
Mixing mould include aspergillus niger, aspergillus flavus, aspergillus ustus, Aspergillus terreus, aspergillus sydowi, Trichoderma viride, cladosporium herbarum, The common bacterium such as Chaetomium globosum and paecilomyces varioti.
The cultivation temperature of bacterium is 36 ± 1 DEG C, and the cultivation temperature of mould is 28 ± 1 DEG C.
Data are the bacteria containing amount after cultivating certain number of days in sample in table 10.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention And range.

Claims (10)

1. a kind of amino acid cleansing cream, which is characterized in that include amino acid surfactant and skin conditioning agent, the skin tune Reason agent includes Sodium Hyaluronate, shale oil sulphonic acid ester sodium, Codium Tomentosum extract, polyquaternium -51, decoyl glycine and without trouble Sub- berry extract.
2. amino acid cleansing as described in claim 1 cream, which is characterized in that the skin conditioning agent include Sodium Hyaluronate, Shale oil sulphonic acid ester sodium, Codium Tomentosum extract solution, -51 solution of polyquaternium, decoyl glycine and soapberry fruit extract Solution;The Codium Tomentosum extract solution is the mixture of Codium Tomentosum extract, butanediol and water;The soapberry fruit mentions Taking object solution is the mixture of soapberry fruit extract and glycerol;- 51 solution of polyquaternium is the water-soluble of polyquaternium -51 Liquid.
3. amino acid cleansing cream as claimed in claim 2, which is characterized in that the component of the skin conditioning agent is in the amino Weight percentage in sour mildy wash are as follows: Sodium Hyaluronate 0.01%~0.3%, shale oil sulphonic acid ester sodium 0.001%~ 0.2%, Codium Tomentosum extract solution 0.01%~1%, -51 solution 0.01%~1% of polyquaternium, decoyl glycine 0.1%~2% and soapberry fruit extract solution 1%~20%.
4. amino acid cleansing cream as claimed in claim 3, which is characterized in that the component of the skin conditioning agent is in the amino Weight percentage in sour mildy wash are as follows: Sodium Hyaluronate 0.05%, shale oil sulphonic acid ester sodium 0.01%, fur pine algae are extracted Object solution 0.05%, -51 solution 0.05% of polyquaternium, decoyl glycine 1% and soapberry fruit extract solution 10%.
5. amino acid cleansing cream as described in claim 1, which is characterized in that the amino acid surfactant includes lauroyl Sodium glutamate and sodium cocoyl glycinate.
6. amino acid cleansing cream as claimed in claim 5, which is characterized in that the component of the amino acid surfactant is in institute State the weight percentage in amino acid cleansing cream are as follows: sodium lauroyl glutamate 10%~40% and sodium cocoyl glycinate 2% ~20%.
7. amino acid cleansing cream as claimed in claim 6, which is characterized in that the sodium lauroyl glutamate and the sweet ammonia of cocounut oil acyl The weight ratio of sour sodium are as follows: sodium lauroyl glutamate: sodium cocoyl glycinate=6:1.
8. amino acid cleansing cream as described in claim 1, which is characterized in that weight percentage, the amino acid are clean Face cream also includes 1,3- propylene glycol 10%~35% and glycine betaine 0.1%~3%.
9. amino acid cleansing cream as described in claim 1, which is characterized in that the amino acid cleansing cream also includes ethylhexyl Glycerol;Preferably, weight percentage of the Sensiva SC50 in amino acid cleansing cream be 0.05%~ 0.3%;Most preferably, weight percentage of the Sensiva SC50 in the amino acid cleansing cream is 0.1%.
10. amino acid cleansing cream as described in claim 1, which is characterized in that weight percentage, the amino acid are clean Face cream also includes chelating agent 0.02%~0.2%, thickener 0.1%~1% and thickening suspending agent 1%~5%;Preferably, institute Stating chelating agent is EDETATE SODIUM;Preferably, the thickener is PEG-150 distearate;Preferably, the thickening suspending agent For acrylic acid (ester) analog copolymer.
CN201811631492.9A 2018-12-28 2018-12-28 Amino acid facial cleanser Active CN109528523B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811631492.9A CN109528523B (en) 2018-12-28 2018-12-28 Amino acid facial cleanser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811631492.9A CN109528523B (en) 2018-12-28 2018-12-28 Amino acid facial cleanser

Publications (2)

Publication Number Publication Date
CN109528523A true CN109528523A (en) 2019-03-29
CN109528523B CN109528523B (en) 2021-10-26

Family

ID=65830938

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811631492.9A Active CN109528523B (en) 2018-12-28 2018-12-28 Amino acid facial cleanser

Country Status (1)

Country Link
CN (1) CN109528523B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110882190A (en) * 2019-11-05 2020-03-17 江苏巴帝恩生物科技有限公司 Soapberry plant extract face-cleaning mousse and preparation method thereof
CN111035574A (en) * 2019-11-20 2020-04-21 湖北研妆实业有限公司 Amino acid antibacterial spray
CN111110577A (en) * 2020-02-27 2020-05-08 陈洁兴 Mild mite-removing itching-relieving shower gel and preparation method thereof
CN111135108A (en) * 2020-01-15 2020-05-12 广东迪美生物技术有限公司 Compound preservative containing amino acid derivatives, preparation method thereof and cosmetics
CN111214389A (en) * 2020-03-16 2020-06-02 中山市天图精细化工有限公司 Post-foaming makeup-removing bubble composition aerosol and preparation method thereof
CN111297792A (en) * 2020-02-26 2020-06-19 广州留今科学研究有限公司 Amino acid surfactant composition containing symbiotic bacteria combined fermentation product, facial cleanser and preparation method of facial cleanser
CN111632014A (en) * 2020-06-18 2020-09-08 广东景兴健康护理实业股份有限公司 Preparation method and application of silk fibroin skin-beautifying sanitary wet tissue additive solution
CN113425661A (en) * 2021-08-11 2021-09-24 广州睿森生物科技有限公司 Plant composition with cleaning and repairing effects and application thereof
CN118078704A (en) * 2024-01-23 2024-05-28 广州美兮生物科技有限公司 Composition with oil control effect and application of composition in shampoo

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050071275A (en) * 2003-12-31 2005-07-07 (주) 이지함 Cosmetic Products and their manufacturing methods helping to improve acnegenic and seborrheic skin through anti-microbial action and inhibitory action of sebum secretion.
EP1765260A2 (en) * 2004-06-03 2007-03-28 Steven J. Brown Sanitizing composition and method of preparation
CN103181862A (en) * 2011-12-29 2013-07-03 上海媚兰生物科技发展有限公司 Composite moisturizing agent and application thereof
CN106109308A (en) * 2016-07-20 2016-11-16 广州艾蓓生物科技有限公司 facial cleaning cream
CN108295021A (en) * 2018-04-04 2018-07-20 广州赛莱拉干细胞科技股份有限公司 Replenishing water and preserving moisture composition and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050071275A (en) * 2003-12-31 2005-07-07 (주) 이지함 Cosmetic Products and their manufacturing methods helping to improve acnegenic and seborrheic skin through anti-microbial action and inhibitory action of sebum secretion.
EP1765260A2 (en) * 2004-06-03 2007-03-28 Steven J. Brown Sanitizing composition and method of preparation
CN103181862A (en) * 2011-12-29 2013-07-03 上海媚兰生物科技发展有限公司 Composite moisturizing agent and application thereof
CN106109308A (en) * 2016-07-20 2016-11-16 广州艾蓓生物科技有限公司 facial cleaning cream
CN108295021A (en) * 2018-04-04 2018-07-20 广州赛莱拉干细胞科技股份有限公司 Replenishing water and preserving moisture composition and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
佛山乐儿阁: "《海洋中最神秘的藻类——软毛松藻》", 15 April 2016, 微信公众平台 *
蔻赛(北京)生物科技有限公司: "《蔻赛氨基酸洁面乳》", 27 November 2017, 国家药品监督管理局 *
裘炳毅等: "《现代化妆品科学与技术》", 31 March 2016, 中国轻工业出版社 *
赛福E家: "《控油,请看我表演》", 21 April 2017, 微信公众平台 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110882190A (en) * 2019-11-05 2020-03-17 江苏巴帝恩生物科技有限公司 Soapberry plant extract face-cleaning mousse and preparation method thereof
CN111035574A (en) * 2019-11-20 2020-04-21 湖北研妆实业有限公司 Amino acid antibacterial spray
CN111135108A (en) * 2020-01-15 2020-05-12 广东迪美生物技术有限公司 Compound preservative containing amino acid derivatives, preparation method thereof and cosmetics
CN111297792A (en) * 2020-02-26 2020-06-19 广州留今科学研究有限公司 Amino acid surfactant composition containing symbiotic bacteria combined fermentation product, facial cleanser and preparation method of facial cleanser
CN111297792B (en) * 2020-02-26 2021-07-27 广州一一生物技术有限公司 Amino acid surfactant composition containing symbiotic bacteria combined fermentation product, facial cleanser and preparation method of facial cleanser
CN111110577A (en) * 2020-02-27 2020-05-08 陈洁兴 Mild mite-removing itching-relieving shower gel and preparation method thereof
CN111214389A (en) * 2020-03-16 2020-06-02 中山市天图精细化工有限公司 Post-foaming makeup-removing bubble composition aerosol and preparation method thereof
CN111632014A (en) * 2020-06-18 2020-09-08 广东景兴健康护理实业股份有限公司 Preparation method and application of silk fibroin skin-beautifying sanitary wet tissue additive solution
CN113425661A (en) * 2021-08-11 2021-09-24 广州睿森生物科技有限公司 Plant composition with cleaning and repairing effects and application thereof
CN113425661B (en) * 2021-08-11 2023-02-10 广州睿森生物科技有限公司 Plant composition with cleaning and repairing effects and application thereof
CN118078704A (en) * 2024-01-23 2024-05-28 广州美兮生物科技有限公司 Composition with oil control effect and application of composition in shampoo

Also Published As

Publication number Publication date
CN109528523B (en) 2021-10-26

Similar Documents

Publication Publication Date Title
CN109528523A (en) A kind of amino acid cleansing cream
CN111631974B (en) Soap ammonia type face cleaning product and preparation method thereof
CN106038330B (en) A kind of mildy wash and preparation method thereof
CN109381363A (en) A kind of amino acid shampoo and preparation method thereof
JP6183849B2 (en) Skin cleanser composition
AU2015419259B2 (en) Personal care composition comprising taurine, arginine, glycine
CN107648096A (en) A kind of children's adacrya hair washing bath foam composition
CN107998028A (en) A kind of shower cream and preparation method thereof
BRPI1003846A2 (en) 4-hexylresorcinol aqueous concentrates with high clarity
CN103720595A (en) Amino acid type pearly facial cleansing foam composition and preparation method thereof
CN107982135A (en) A kind of shampoo and preparation method thereof
CN104800096A (en) Efficient moisturizing composition applied to cosmetics
JP2010522757A (en) Treatment of mammalian skin with skin emollient fungicide
CN107854329B (en) A kind of antibacterial moisturizing foam hand cleanser of easy wash type and preparation method thereof
CN110772437A (en) Wash-free cleaning composition capable of rapidly absorbing oil, preparation method and application thereof in hair wet tissue
JP5912397B2 (en) Cosmetic liquid, cosmetic liquid production method and cosmetic method
CN113577000B (en) Facial cleanser containing dendrobium officinale extract and preparation method thereof
CN112891261B (en) Composition for reducing irritation of surfactant and application of composition in soap
CN113318008B (en) Bath composition and preparation method thereof
KR20190070556A (en) Face Cleansing Composition having Spicule
BR112015004733B1 (en) cosmetic and / or dermatological composition, method for its preparation and use thereof
KR20190070534A (en) Face Cleansing Composition having Spicule
JPS5914518B2 (en) Liquid shampoo composition
RU2331405C2 (en) Cosmetic composition "love secrets" for washing hair and/or skin
KR970004981B1 (en) Composition of soap

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: 510000 floors 4-5, building 2, Yucai Road 12, Shiling Town, Huadu District, Guangzhou City, Guangdong Province

Applicant after: Beiyouqing (Guangdong) Health Technology Co.,Ltd.

Address before: 510000 floors 4-5, building 2, Yucai Road 12, Shiling Town, Huadu District, Guangzhou City, Guangdong Province

Applicant before: GUANGZHOU COSE BIOTECHNOLOGY Co.,Ltd.

CB02 Change of applicant information
GR01 Patent grant
GR01 Patent grant