CN111632014A

CN111632014A - Preparation method and application of silk fibroin skin-beautifying sanitary wet tissue additive solution

Info

Publication number: CN111632014A
Application number: CN202010559874.6A
Authority: CN
Inventors: 许旭芳; 胡伟; 陈耀祖
Original assignee: Kingdom Healthcare Holdings Ltd Guangdong
Current assignee: Kingdom Healthcare Holdings Ltd Guangdong
Priority date: 2020-06-18
Filing date: 2020-06-18
Publication date: 2020-09-08

Abstract

The invention discloses a preparation method and application of an additive solution of a silk fibroin skin-beautifying sanitary wet tissue, wherein the additive solution is prepared from the following raw materials in percentage by weight: 5.0 to 8.0 percent of natural silk extract, 3.0 to 5.0 percent of hydrolyzed red algae extract, 1.0 to 2.0 percent of water-soluble grease, 2.0 to 6.0 percent of polyalcohol solvent, 0.5 to 1.0 percent of skin conditioner, 0.5 to 1.0 percent of non-irritant antiseptic composition, 0.2 to 0.6 percent of lactic acid, 0.2 to 0.6 percent of essential oil and the balance of pure water, and the components have synergistic action to obviously reduce the irritation and the dry and astringent feeling of the pudendum, meanwhile, the sanitary wet tissue can effectively clean the dirt on the epidermis, relieve the inflammation and the pruritus of the pudendum, relieve the stabbing pain, the sticky feeling and other symptoms, the product contains various amino acids, has good functions of moisture absorption, water retention and compactness, and can delay the senility of pudendum, and the added non-irritant antiseptic combination can effectively inhibit bacteria.

Description

Preparation method and application of silk fibroin skin-beautifying sanitary wet tissue additive solution

Technical Field

The invention relates to a disposable sanitary product, in particular to a preparation method and application of an additive solution of a silk fibroin skin-beautifying sanitary wet tissue.

Background

The urban life rhythm is fast, people pursue a cleaning product which is faster and more convenient, particularly, the private skin during menstruation is very fragile and very suitable for breeding bacteria, and the female can easily have dry and astringent skin, pudendum pruritus and other symptoms due to the reduced resistance during menstruation and the long-time use of the sanitary towel.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a preparation method and application of a silk fibroin skin-beautifying sanitary wet tissue additive solution.

The technical scheme adopted by the invention for solving the technical problems is as follows:

the silk fibroin skin-beautifying sanitary wet tissue additive solution is prepared from the following raw materials in percentage by weight: 5.0-8.0% of natural silk extract, 3.0-5.0% of hydrolyzed red algae extract, 1.0-2.0% of water-soluble grease, 2.0-6.0% of polyalcohol solvent, 0.5-1.0% of skin conditioner, 0.5-1.0% of non-irritant antiseptic composition, 0.2-0.6% of lactic acid, 0.2-0.6% of essential oil and the balance of pure water.

The water-soluble grease is hydrogenated jojoba oil.

The polyalcohol solvent is glycerol, butanediol and propylene glycol in the same proportion.

The skin conditioner is caprylyl glycine.

The non-irritating and antiseptic composition comprises glyceryl caprylate, caprylyl hydroxamic acid, p-hydroxyacetophenone and butanediol in the same proportion.

The essential oil is agilawood essential oil.

A method for preparing the silk fibroin skin-beautifying sanitary wet tissue additive solution comprises the following steps:

1) adding the pure water in parts by weight into a main stirring kettle, adding the natural silk extract and the hydrolyzed red algae extract in parts by weight into the main stirring kettle, and stirring for 5-10 minutes at a rotating speed of 50-60 rpm.

2) Adding the polyol solvent and the skin conditioner in parts by weight into a heating and stirring barrel, and then stirring and dissolving at the temperature of 75-80 ℃ and the rotating speed of 50-60 r/min until the mixture is clear and transparent to obtain the component A.

3) Adding the water-soluble grease, the non-irritant anticorrosion composition and the essential oil in parts by weight into a stirrer, and mixing for 5-10 minutes at a rotating speed of 50-60 revolutions per minute to obtain a component B.

4) Adding the component A into a main stirring kettle, keeping the rotation speed at 50-60 rpm, stirring for 5-10 minutes, adding the component B into the main stirring kettle at the temperature below 45 ℃, keeping the rotation speed at 50-60 rpm, stirring for 5-10 minutes, adding the lactic acid in parts by weight into the main stirring kettle, keeping the rotation speed at 50-60 rpm, stirring for 10-15 minutes, standing, and discharging.

The sanitary wet tissue using the silk fibroin skin-beautifying sanitary wet tissue additive solution uses non-woven fabric as a carrier, and after the non-woven fabric is wetted by the silk fibroin skin-beautifying sanitary wet tissue additive solution, the non-woven fabric is subjected to roller extrusion and finally is subjected to folding packaging.

The invention has the beneficial effects that: according to the sanitary wet tissue prepared by the invention, the natural silk extract, the hydrolyzed red algae extract, the water-soluble grease, the polyol solvent, the skin conditioner, the non-irritating and anti-corrosion combination and the lactic acid and the essential oil are added to enable the synergistic effect among the components to obviously reduce the irritation and the dry feeling of the pudendum, meanwhile, the sanitary wet tissue can effectively clean the dirt on the epidermis, relieve the symptoms of pudendum inflammation, pudendum itch, relieve the irritation and the sticky feeling and bring the use experience of clear perfume moistening to users, the product contains various amino acids, has good moisture absorption and retention and firming functions, delays the aging of the pudendum, and the added non-irritating and anti-corrosion combination can effectively inhibit bacteria.

Drawings

The invention is further illustrated with reference to the following figures and examples.

FIG. 1 is a graph comparing the moisture content of the present invention;

fig. 2 is a comparative image of skin desquamation according to the present invention.

Detailed Description

In the present example, the temperature and pressure are not particularly emphasized, and both are normal temperature and normal pressure.

The silk fibroin skin-beautifying sanitary wet tissue additive solution provides the following three specific embodiments, and is prepared from the following raw materials in percentage by weight:

example 1: 5.0% of natural silk extract, 3.0% of hydrolyzed red algae extract, 1.0% of water-soluble grease, 2.0% of polyol solvent, 0.5% of skin conditioner, 0.5% of non-irritant preservative composition, 0.2% of lactic acid, 0.2% of essential oil and the balance of pure water.

Example 2: 4.5% of natural silk extract, 4% of hydrolyzed red algae extract, 1.5% of water-soluble grease, 4.0% of polyol solvent, 0.75% of skin conditioner, 0.75% of non-irritant preservative composition, 0.4% of lactic acid, 0.4% of essential oil and the balance of pure water.

Example 3: 8.0% of natural silk extract, 5.0% of hydrolyzed red algae extract, 2.0% of water-soluble grease, 6.0% of polyol solvent, 1.0% of skin conditioner, 1.0% of non-irritant preservative composition, 0.6% of lactic acid, 0.6% of essential oil and the balance of pure water.

The natural silk extract (produced by Suzhou Meiyichen biotechnology limited) is in a liquid state, does not contain any preservative or sensitization component, has the main effects of moistening and moisturizing and can achieve the effects of tightening and repairing. The natural silk is an oxygen supply body, can eliminate active oxygen, has an antioxidation effect, and protects cells of vulva from being damaged by free radicals and toxic wastes in vivo, thereby maintaining the stability of cell membrane and organelle. In addition, the natural silk extract has various amino acids, has good moisture absorption and retention functions, has strong permeability and affinity to skin, can improve the activity of vulvar skin cells and delay the aging of the vulvar, serine in the natural silk extract has an inhibiting effect on the activity of tyrosinase, the tyrosinase is a key enzyme for melanin synthesis, the activity of the tyrosinase determines the amount of melanin formation, and the characterization is the shade of the vulvar skin color, so the serine can prevent color spots formed by skin aging.

The hydrolyzed red algae extract (manufactured by Guangdong Soxhlet chemical Co., Ltd.) contains abundant carbohydrates, proteins, lipids, trace elements, mineral substances, vitamins and the like, vitamins comprise vitamin C and vitamin E, the vitamin C can effectively resist oxidation and remove wrinkles, the vitamin C participates in hydroxylation reaction to synthesize collagen, the collagen is supplemented for skin, the originally damaged or sunken skin can be repaired, and the normal state of the skin can be recovered. The vitamin E has stronger inoxidizability, can effectively prolong the shelf life of the invention, prevent the oxidation rancidity phenomenon caused by illumination, heat radiation and contact with air, can effectively eliminate the deposition of lipofuscin in cells, improves the normal functions of the cells and can effectively reduce pigment spots. In addition, the protein contained in the hydrolyzed red algae extract comprises methionine and cystine, has good moisture retention and tightening performance, and can regulate the secretion of vulvar skin, regulate the water-oil balance of skin, and effectively shrink and tighten skin pores.

The water-soluble oil is hydrogenated jojoba oil (produced by Guangdong Kesuo chemical Co., Ltd.), has similar components with sebum of human body, is easily absorbed by skin, can be mixed with sebum, and does not leave greasy feeling after use.

The polyalcohol solvent is glycerol, butanediol and propylene glycol in the same proportion, and the polyalcohol solvent is used as an embedding material, has high safety to skin, and can improve the stability, dispersibility and utilization rate of volatile components of the embodiment.

The skin conditioner is caprylyl glycine (produced by Saian asparagus biotech Co., Ltd.), and the caprylyl glycine can generate strong bionic property on skin, can inhibit undesirable skin flora, and can act on reduction biological enzyme to regulate skin oil secretion.

The glyceryl caprylate can reduce the affinity with cell membrane lipid in an oil-water interface, and the glyceryl caprylate can cause the leakage of content substances in cells and the change of ion concentration in the cells by damaging cell walls, cell membranes and organelle lipid membranes, so that the microorganisms are finally killed, and the bacteriostatic effect is achieved.

The caprylyl hydroximic acid has efficient and selective chelating capacity on ferrous ions and ferric ions, and in an environment with limited ferric ions, the growth of mould is limited, and the caprylyl hydroximic acid has the optimal carbon chain length capable of promoting the degradation of a cell membrane structure, so that the caprylyl hydroximic acid has strong antibacterial capacity.

The lactic acid (produced by Hubei Zhuangmei Biotech Co., Ltd.) is weakly acidic, so that the acidity of the vulva is always regulated, and the additive solution can be prevented from being dried and cracked after being formed on the non-woven fabric.

The essential oil is agilawood essential oil (produced by Guangzhou Artemisia argyi biotechnology limited), is a natural perfume, is slightly fishy after being smeared, is dense and fragrant with a characteristic medicine of agilawood, is lingering sweet after being fragrant, leaves aftertaste, is lasting in fragrance, contains aquilaria acid, plays a certain role in analgesia and inflammation diminishing, is mainly caused by severe contraction of uterine smooth muscle, and has an inhibiting effect and an antispasmodic effect on contraction of the uterine smooth muscle due to valerienic acid, alpha-santalol and agarolspironol in the agilawood essential oil, so that the dysmenorrhea can be effectively relieved.

1) adding the pure water in parts by weight into a main stirring kettle, adding the natural silk extract and the hydrolyzed red algae extract in parts by weight into the main stirring kettle, and then stirring for 5-10 minutes at a rotating speed of 50-60 rpm (10 minutes for example 1, 7 minutes for example 2 and 5 minutes for example 3).

2) Adding the above parts by weight of the polyol solvent and the skin conditioner into a heating and stirring barrel, and stirring and dissolving at the temperature of 75-80 ℃ (75 ℃ in example 1, 77 ℃ in example 2 and 80 ℃ in example 3) at the rotation speed of 50-60 rpm until the mixture is clear and transparent (visual inspection is carried out until the mixture is clear and transparent), thus obtaining the component A.

3) And adding the water-soluble oil, the non-irritant preservative combination and the essential oil in parts by weight into a stirrer, and mixing at the rotating speed of 50-60 rpm for 5-10 minutes (10 minutes in example 1, 7 minutes in example 2 and 5 minutes in example 3) to obtain a component B.

4) Adding the component A into a main stirring kettle, stirring at 50-60 rpm for 5-10 minutes (10 minutes in example 1, 7 minutes in example 2 and 5 minutes in example 3), adding the component B into the main stirring kettle at 45 ℃ or below, stirring at 50-60 rpm for 5-10 minutes (10 minutes in example 1, 7 minutes in example 2 and 5 minutes in example 3), adding the above-mentioned weight parts of lactic acid into the main stirring kettle, stirring at 50-60 rpm for 10-15 minutes (15 minutes in example 1, 12 minutes in example 2 and 10 minutes in example 3), standing, and discharging.

In the above steps, the rotation speed portions were 50 rpm for example 1, 55 rpm for example 2, and 60 rpm for example 3.

Referring to fig. 1 to 2, the silk fibroin skin-beautifying sanitary wet tissue additive solution prepared in example 2 was applied to the arms of volunteers for absorption, distilled water was used as a control group, the moisture content of the test part was detected, and the test subjects were 5 women aged 24-29 years old, and the test method was that the test material was applied in the amount of μ l/2cm²After the test material was dried, the test site was washed with 20. mu.l of distilled water, wiped with Kim-Wipes dust-free paper, and then the moisture content of the test site was measured once per minute by a skin moisture meter (CM 825).

Experiments prove that the silk fibroin skin-beautifying sanitary wet tissue additive solution and natural moisturizing factors in skin have similar amino acid composition, and have the characteristics of excellent moisturizing performance, moisturizing and moisturizing, and reduction of skin barrier damage caused by over-cleaning.

Actual use test of volunteers:

volunteers are recruited in a gynecological clinic of a certain hospital, and the conditions of the recruited volunteers are as follows: has the advantages of having women who use the sanitary wet tissue during menstrual period and have sensitive pudendum. The method is characterized in that the sanitary wet tissue with the use amount of 2 months is distributed to volunteers at one time, 40 women of the volunteers are recruited and randomly divided into 5 groups, and the groups are as follows: group 1, group 2, group 3 and group 4. The sanitary wet tissue product of example 1 was used in group 1, the sanitary wet tissue product of example 2 was used in group 2, the sanitary wet tissue product of example 3 was used in group 3, and a commercially available aloe moisturizing type sanitary wet tissue was used in group 4.

In the measurement experiment, the used sanitary wet tissues are all torn off the marked substances such as trademarks, and the user does not know the used sanitary wet tissues. Volunteers need to provide the experimenters with self use feelings after the end of the monthly period. The use experience comprises: whether itch can be relieved after the private part is wiped, whether stabbing pain exists in use or not, the four sensory experiences of wiping the sticky feeling and the clear perfume moistening and rest feeling are graded, the fullness of each grade is very, the better the feeling is, the higher the grade is, the average grade of the three grades of all groups of volunteers in three menstrual periods is calculated, and the measurement results are shown in the following table:

from the table data, it can be seen that: compared with the commercially available sanitary wet tissue, the silk fibroin skin-beautifying sanitary wet tissue prepared by the invention has the advantages that the irritation and the dryness between pudendums are obviously reduced. Meanwhile, the sanitary wet tissue prepared by the invention can effectively clean the dirt on the epidermis, relieve the symptoms of pudendum inflammation, pudendum pruritus, stabbing pain, sticky feeling and the like, and bring the use experience of moistening with clean perfume to users. The sanitary wet tissue prepared by the invention can effectively reduce the stimulation to the pudendum on the basis of effectively playing the role of resisting (inhibiting) bacteria, and meanwhile, the silk fibroin skin-beautifying component is an amino acid substance, so that the dryness and astringency of the pudendum can be effectively reduced, the moisturizing effect is realized, and the use feeling is further improved.

The above embodiments do not limit the scope of the present invention, and those skilled in the art can make equivalent modifications and variations without departing from the overall concept of the present invention.

Claims

1. The silk fibroin skin-beautifying sanitary wet tissue additive solution is characterized by being prepared from the following raw materials in percentage by weight: 5.0-8.0% of natural silk extract, 3.0-5.0% of hydrolyzed red algae extract, 1.0-2.0% of water-soluble grease, 2.0-6.0% of polyalcohol solvent, 0.5-1.0% of skin conditioner, 0.5-1.0% of non-irritant antiseptic composition, 0.2-0.6% of lactic acid, 0.2-0.6% of essential oil and the balance of pure water.

2. The silk fibroin myo-beautifying sanitary wet tissue additive solution as claimed in claim 1, wherein the water-soluble oil is hydrogenated jojoba oil.

3. The silk fibroin myo-beautifying sanitary wet tissue additive solution as claimed in claim 1, characterized in that the polyol solvent is glycerol, butanediol and propylene glycol in the same ratio.

4. The silk fibroin muscle-beautifying sanitary wet tissue additive solution as claimed in claim 1, wherein the skin conditioning agent is caprylyl glycine.

5. The silk fibroin muscle-beautifying sanitary wet tissue additive solution according to claim 1, characterized in that the non-irritating and antiseptic combination is glyceryl caprylate, caprylyl hydroxamic acid, p-hydroxyacetophenone and butylene glycol in the same ratio.

6. The silk fibroin muscle-beautifying sanitary wet tissue additive solution as claimed in claim 1, wherein the essential oil is agilawood essential oil.

7. A method for preparing the silk fibroin myo-beautifying sanitary wet tissue additive solution as defined in any one of claims 1 to 6, which is characterized by comprising the following steps:

1) adding the pure water in parts by weight into a main stirring kettle, adding the natural silk extract and the hydrolyzed red algae extract in parts by weight into the main stirring kettle, and stirring for 5-10 minutes at a rotating speed of 50-60 rpm;

2) adding the polyol solvent and the skin conditioner in parts by weight into a heating and stirring barrel, and stirring and dissolving at the temperature of 75-80 ℃ and the rotating speed of 50-60 r/min until the mixture is clear and transparent to obtain a component A;

3) adding the water-soluble grease, the non-irritant anticorrosion composition and the essential oil in parts by weight into a stirrer, and mixing for 5-10 minutes at a rotating speed of 50-60 revolutions per minute to obtain a component B;

8. The silk fibroin muscle-beautifying wet tissue additive solution as defined in any one of claims 1 to 6, wherein the wet tissue takes a non-woven fabric as a carrier, the non-woven fabric is wetted by the silk fibroin muscle-beautifying wet tissue additive solution, then the non-woven fabric is subjected to roller extrusion, and finally the silk fibroin muscle-beautifying wet tissue additive solution is subjected to folding packaging.