CN105013001A - Medical biological hydrogel function dressing for gynecology and preparation method of dressing - Google Patents
Medical biological hydrogel function dressing for gynecology and preparation method of dressing Download PDFInfo
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- CN105013001A CN105013001A CN201510529307.5A CN201510529307A CN105013001A CN 105013001 A CN105013001 A CN 105013001A CN 201510529307 A CN201510529307 A CN 201510529307A CN 105013001 A CN105013001 A CN 105013001A
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Abstract
The invention relates to the technical field of vaginitis treatment and nursing, in particular to a medical biological hydrogel function dressing for the gynecology and a preparation method of the dressing. The medical biological hydrogel function dressing for the gynecology comprises materials in percentage by weight as follows: 7.5%-12% of chitosan quanternary ammonium salt, 0.21%-0.36% of sodium alginate, 12%-18% of glycerin, 0.22%-0.35% of gelatin, 0.35%-0.7% of magnesium ascorbyl phosphate, 0.008%-0.012% of cell growth factors, 0.15%-0.24% of ceramide, 0.45%-0.75% of azone, 0.35%-0.65% of mint oil and the balance of purified water. The dressing can be used for repairing and treating gynecological inflammations such as vaginitis and has effects of stopping bleeding, relieving pain and repairing wounds; the dressing has effects that the dressing takes effect quickly and is free of side effects on the gynecological inflammations.
Description
Technical field
The present invention relates to vaginitis treatment and nursing technique field, particularly relate to a kind of gynecological medical biological hydrogel functional dressings and preparation method thereof.
Background technology
Vaginitis is the inflammation of connective tissue under vaginal mucosa, be gynecological common disease; Treatment bacterial vaginitis the most effective medicine is mostly metronidazole or tinidazole, and it is responsive to the most anaerobe of intravaginal, and intravaginal acid-base value is declined and suppresses the Growth and reproduction of vagina Gartner bacterium.
Although adopt Drug therapy can play the effect for the treatment of inflammation fast, can endocrine be had influence on, produce untoward reaction, damage is caused to health.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide a kind of gynecological medical biological hydrogel functional dressings and preparation method thereof, this dressing can carry out nursing sterilization to vagina, and has no side effect.
A kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 7.5 ~ 12%
Sodium alginate 0.21 ~ 0.36%
Glycerol 12 ~ 18%
Gelatin 0.22 ~ 0.35%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.35 ~ 0.7%
Cell growth factor 0.008 ~ 0.012%
Ceramide 0.15 ~ 0.24%
Laurocapram 0.45 ~ 0.75%
Oleum menthae 0.35 ~ 0.65%
Purified water surplus.
A kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9 ~ 11%
Sodium alginate 0.28 ~ 0.32%
Glycerol 14 ~ 16%
Gelatin 0.27 ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4 ~ 0.6%
Cell growth factor 0.009 ~ 0.011%
Ceramide 0.18 ~ 0.21%
Laurocapram 0.55 ~ 0.7%
Oleum menthae 0.45 ~ 0.55%
Purified water surplus.
A kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 10%
Sodium alginate 0.3
Glycerol 15%
Gelatin 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.2%
Laurocapram 0.6%
Oleum menthae 0.5%
Purified water surplus.
Cure mechanism is:
Water instant cation chitosan quaternary ammonium salt has the performances such as good antibiotic property, film property, cation-adsorption, moisture absorbability and moisture retentivity, flocculability, antistatic behaviour.Its anti-microbial property is better than chitosan and other chitosan derivatives.After chitosan quaternary ammonium salt is water-soluble, ionize, containing a large amount of level Four ammonium cations in solution.Ammonium cation has certain fragmentation effect to antibacterial, fungus, virus.
Sodium alginate is used for, in some liquid medicines, can strengthening viscosity, improving the suspension of solid.Propylene glycol alginate can improve the stability of Emulsion.Controlled Release Drug Delivery system accounts for very consequence in health care.Time before water soluble drug microgranule is separated from gelatinous medium will minimize to guarantee that drug loading is maximum.But this is unimportant to water-insoluble drug.They find that the release of medicine is relevant with the dissolubility of medicine used.
Sodium alginate is slightly soluble in water, is insoluble to majority of organic solvent.It is dissolved in alkaline solution, makes solution have viscosity.Sodium alginate powder is met water and is become wet, and the hydration of microgranule makes its surface have viscosity.Then microgranule is bonded together rapidly formation agglomerate, agglomerate aquation dissolving completely very slowly.If compete the compound of hydration in water containing other and alginate, then sodium alginate is more difficult is dissolved in the water.Sugar in water, starch or protein can reduce the hydration rate of sodium alginate, and incorporation time is necessary to extend.The salt (as NaCl) of univalent cation concentration higher than 0.5% time also have similar effect.The pH value of sodium alginate in the distilled water solution of 1% is about 7.2.
Sodium alginate has hygroscopicity, and during balance, the number of contained humidity depends on relative humidity.Dry sodium alginate in the container of good seal in 25 DEG C and following temperature storage quite stable.Sodium alginate soln is stable when pH5 ~ 9.The degree of polymerization (DP) and molecular weight directly related with the viscosity of sodium alginate soln, during storage the reduction of viscosity can be used to estimate sodium alginate go be polymerized degree.The sodium alginate stability of high polymerization degree is not as good as the sodium alginate of low polymerization degree.It is reported that sodium alginate can be hydrolyzed through proton catalysis, time, pH and temperature are depended in this hydrolysis.Alginate propylene glycol ester solution at room temperature, pH3 ~ 4 time stable; PH be less than 2 or be greater than 6 time, even if at room temperature viscosity also can reduce very soon.
Sodium alginate is a kind of macromolecular compound of high viscosity.The difference of it and starch, cellulose etc., being that it has carboxyl, is the high polyuronide that the aldehyde radical of beta-D-mannuronic acid is formed with glycosidic bond.Its functional character is as follows:
(1) hydrophilic is strong, can dissolve, form the uniform solution of very thickness in cold water and warm water.
(2) true solution formed has flexibility, homogeneity and other good characteristics that other analog are difficult to obtain.
(3) there is the effect of very strong protecting colloid, strong to the emulsifying ability of oils and fats.
(4) add the slaines such as aluminum, barium, calcium, copper, ferrum, lead, zinc, nickel in the solution, insoluble alginate will be generated.These slaines are buffer agents of phosphate, acetate etc. of sodium, potassium, can suppress, retarded coagulation.
(5) pH value is 7 usually, in neutral, can adjust between 4-10.
(6) be wire polyelectrolyte, can be made into tough fiber (alginate fiber) or thin film, have and prevent be full of cracks effect.
The technological process of sodium alginate is as follows: dry or wet zostera marina (algae) through pulverizing, the extraction of ion, highly basic water, clarify and to obtain thick alginate solution, colored calcium alginate is obtained through calcium chloride precipitation, with acid treatment after decolouring, de-taste, removing soluble impurity obtains alginic acid precipitation, obtain sodium alginate with sodium carbonate effect, then drying, pulverize, sieve to obtain sodium alginate powder.
Glycerol, namely glycerol is without the sweet clear and bright thick liquid of color and taste, odorless; There is warm sweet taste.Glycerol can moisture content in draw air to skin moisture-keeping, also the moisture content in skin can be pinned, not allow it run off.There is effect of moisturizing.Moisturizing, moist effect can be played to skin.
Gelatin is most important functional: gelation, it refers to that gelatin molecule reverts to orderly triple-helix structure gradually by random coil state under certain condition, this process mainly divides three phases: first, when temperature be down to freezing point about (35 DEG C) below time, in gelatin solution, the polypeptide chain of random coil revolves into left hand helix again, between adjacent left hand helix segment, effect produces hydrogen bond crosslinks, and again form the nucleus of class collagen helix body, this process is called " renaturation "; The second, the polymerization of class collagen helix body forms microgel; 3rd, aggregation forms the network gel with certain rigidity further.The gelation of gelatin forms by the aminoacid of gelatin, mean molecule quantity and molecular weight distribution, gelatin concentration and PH, gelling temp and the various factors such as time that congeal.
Gelatin: dissolve in hot water, is insoluble to cold water, but can slowly imbibition soften, and gelatin Absorbable rod is equivalent to weight 5-10 water doubly.
Gelatin forms: in gelatin, moisture and inorganic salt account for 16% greatly, and protein content accounts for more than 82%.Similar with parent collagen, gelatin is also made up of 18 seed amino acids, and wherein the content of imino acid Pro and Hyp is higher.The properity of existence to gelatin of these two kinds of imino acids has a very important role.
Structure: the class triple-helix structure in gelatin gel mainly maintains by oxygen key in molecule and the hydration of oxygen key ,-the NH of the Pro ,-OH of Hyp all can form oxygen key with other amino acid side groups and hydrone, are beneficial to the stable of class triple-helix structure.Therefore, the gelling performance of the mammal gelatin that imino acid content is high is better than fishskin gelatin.
Magnesium L-Asacorbic Acid 2-O-Phosphate is vitamin C derivatives, be that raw material modern science and technology process with vitamin C, no matter oral this product is or after being absorbed entered human body by skin, all to dissociate vitamin C by the rapid enzymolysis of phosphate, play the distinctive biochemical functions of vitamin C.
Magnesium L-Asacorbic Acid 2-O-Phosphate is a kind of water solublity whitening agent.This product is after skin absorbs, effectively can resist ultraviolet invasion and attack, and can oxygen-derived free radicals be caught, promote that collagen protein generates, effectively can prevent and treat pigmentation, dispel various skin splash, skin moisturizing, delicate, bright and clean and this product can be made to stablize, nontoxic, non-stimulated, for the excellent additive of modern functional skin-lightening cosmetic, also have: 1, tyrosinase activity processed, vat black pigment, the effect of tool freckle removing and whitening.2, enter after in body and can eliminate oxygen-derived free radicals, thus there is wrinkle removing, anti-senescence function.3, synergism is had with vitamin E.
Cell growth factor is a kind of multifunctional powerful cytokine, to promoting that the formation of fibroblastic metabolism and collagen protein plays critical function.Cell growth factor can promote the growth and breeding of skin histology, and it is by being combined with specific cell surface receptors, regulation and control skin epidermis, and the division of endothelium and stromal cell, Growth and Reproduction differentiation, promote cellular metabolism, strengthen Oxidation; Can promote to breed with the ramp of skin injury cells involved, and regulate the synthesis of intercellular matrix, secretion and decomposition; The regeneration of corneocyte can be promoted, accelerate the reparation of keratodermatitis and hypothallus, promote the growth of human skin cell; Synthesis and the cellular metabolism of the protein of Skin Cell can be strengthened, there is skin-cell aging delaying, the reparation promoting epidermis cell and growth, make skin smooth plump.
Ceramide, also known as sphingolipid, is a kind of lipid being present in skin, plays an important role in epidermal keratinocytes layer formation process.When drying, desquamation, cracking phenomena appear in skin, when its barrier function obviously reduces, skin supplements ceramide can recover rapidly moisturizing and barrier function.
Cause xerosis cutis main cause to be that in horny layer of epidermis, ceramide content reduces, ceramide content height is directly related with skin dryness.Use ceramide can obviously strengthen adhesion strength between keratinocyte, improve skin dryness, reduce desquamation phenomenon.Ceramide has very strong associated water molecule ability, and it maintains moisture of skin by forming network structure in horny layer.Therefore, ceramide has the effect of maintenance moisture of skin.Use ceramide that ceramide content in horny layer of epidermis can be made to increase, xerosis cutis, desquamation, the situation such as coarse can be improved; Ceramide can increase epidermal keratinocytes layer thickness simultaneously, improves skin moisture holding capacity, reduces wrinkle, strengthens skin elasticity, delay skin aging.
Ceramide is a kind of water-soluble grease metallic substance, and it is close with the structure of matter forming keratodermatitis, can penetrate into skin very soon, and the water in horny layer combines, and forms a kind of network structure, pins moisture.
Laurocapram is nonpolar transdermal enhancer, and it can make cutin softening, strengthens permeability, makes drugs through skin barrier, improves local or systemic blood levels, improves preparation bioavailability.All Penetration enhance is had to lipotropy hydrophilic medicament.Be a kind of new and effective penetrating agent, due to use safety, efficient, nontoxic, consumption is few and all have hydrophilic and hydrophobic compound and shortly ooze the advantages such as effect, is one of current classic drug transdermal promoter
Oleum menthae, skin that is unclean, that block can be nursed one's health, its refrigerant sensation, can blood capillary be shunk, releive itch, inflammation and burning, also can soft skin, also effect is had for removing blackhead and oiliness skin quality.
Oleum menthae has inhibitory action to herpes simplex virus, forest virus, mumps virus, has bacteriostasis to staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc.; Water solublity Oleum menthae can excite nerve tip cold receptor and produce creeping chill, and reflexive cause the change of deep tissue blood vessel and play antiinflammatory, pain relieving, antipruritic effect.
Chitosan quaternary ammonium salt mainly plays sterilization, anti-microbial property; For clearing up the antibacterial of vagina inside.Sodium alginate, secondly can to grease emulsifying for adjusting the viscosity of dressing, suppression, retarded coagulation; Assisting sterilisation, antibacterial; Glycerol is mainly used in the effect of moisture moisturizing, lubrication, avoids vagina drying not easy to apply; Gelatin, for gel, as the regulator of gel; Magnesium L-Asacorbic Acid 2-O-Phosphate can play antioxidation, can catch oxygen-derived free radicals, promotes that collagen protein generates, protection vaginal mucosa; Certain antioxidation, skin effect can also be played.Cell growth factor, repairs the Skin Cell being subject to wound site, promotes cell to increase and promotes wound healing.Ceramide can be used for antiallergic, simultaneously with the horny layer of epidermis effect of mucosa, forms barrier, recovers moisturizing rapidly.Laurocapram all has obvious transdermal to help the effect of oozing to hydrophilic and lipophilic drugs, and ancillary drug enters skin inside.Oleum menthae mainly plays pain relieving, antipruritic effect; And auxiliary sterilization, cleaning effect.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Preferably, a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9 ~ 11%
Sodium alginate 0.28 ~ 0.32%
Glycerol 14 ~ 16%
Gelatin 0.27 ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4 ~ 0.6%
Cell growth factor 0.009 ~ 0.011%
Ceramide 0.18 ~ 0.21%
Laurocapram 0.55 ~ 0.7%
Oleum menthae 0.45 ~ 0.55%
Aloin 0.8 ~ 1%
Purified water surplus.
Aloin can help to discharge dirt in body, purifies the blood, vessel softening, reduces blood pressure and blood viscosity, blood circulation promoting; The mixture of active component based on barbaloin is dicotyledon Aloe extract.Bactericidal action, antiinflammatory action, moistening beautification function, lets out effect under stomach invigorating, the heart tonifying effect of invigorating blood circulation, immunity and regeneration, immunity and antitumor action, Detoxication, anti-aging effects, analgesia, sedation, anti-sunlight function.The polysaccharide contained in Aloe and multivitamin have good nutrition, moist, whitening effect to human body skin.Aloe Barbadensis Miller is the Fresh leaf of aloe that optimum is directly improved looks, i.e. Aloe vulgaris, and it has the performance making skin contraction, softnessization, moisturizing, antiinflammatory, bleaching.Remove sclerosis, keratinization in addition, improve the effect of scar, little wrinkle, eye pouch, cutis laxa can not only be prevented, skin wet, tender and lovely can also be kept, simultaneously, can also scytitis be treated, also have good curative effect to acne, freckle, acne and scald, knife injury, insect bite etc.Effective too to hair, hair can be made to keep moistening smooth, pre-Anti-hair loss.
Gynecological inflammation often along with wound occur and hemorrhage, need to carry out sterilization processing to wound, and hemostasis.The good therapeutic effect of aloin.In dressing, increase a certain amount of aloin, certain haemostatic effect and antibacterial, antiinflammatory can be played; By clinical trial, do not conflict with other drug composition.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Further preferably, a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9 ~ 11%
Sodium alginate 0.28 ~ 0.32%
Glycerol 14 ~ 16%
Gelatin 0.27 ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4 ~ 0.6%
Cell growth factor 0.009 ~ 0.011%
Ceramide 0.18 ~ 0.21%
Laurocapram 0.55 ~ 0.7%
Oleum menthae 0.45 ~ 0.55%
Aloin 0.8 ~ 1%
Hydrogen peroxide 1 ~ 2%
Purified water surplus.
Hydrogen peroxide has good oxidation effectiveness, when adopting the wound of the hydrogen peroxide of low concentration (especially weight ratio is lower than 3%) and skin, pus or dirt to meet, decomposes immediately and generates oxygen.This oxygen atom being not yet combined into oxygen molecule, has very strong oxidability, when contacting with antibacterial, can destroy microorganism, kill antibacterial.Can provide an aerobic environment, the collagen protein killing anaerobe and aid in skin is formed simultaneously.Here the content of hydrogen peroxide refers to: the weight content of hydrogen peroxide in whole dressing: 1% ~ 2%.Here hydrogen peroxide content is the content of pure hydrogen peroxide.
In gynaecopathia, mainly concentrate on vaginitis, cervicitis etc., these positions are in the state comparatively closed, the antibacterial grown great majority are for anaerobic bacteria; Increase aqueous hydrogen peroxide composition, can aerobic environment be formed, improve bactericidal effect.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Beneficial effect of the present invention is: the present invention may be used for repairing and treatment vaginitis, has the effect of hemostasis, pain relieving, reparation wound; For gynecological inflammation, it is fast that the present invention has curative effect, the effect had no side effect.
Detailed description of the invention
Below the present invention is described further.
Embodiment 1: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 7.5%
Sodium alginate 0.21%
Glycerol 18%
Gelatin 0.35%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.35%
Cell growth factor 0.008%
Ceramide 0.24%
Laurocapram 0.75%
Oleum menthae 0.35%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 1:
Huang, female, 21 years old, suffer from vaginitis, leucorrhoea grow in quantity has abnormal flavour, and is often with the blood streak.The gynecological medical biological hydrogel functional dressings of the present embodiment is used to clean vagina, nurse, every day 3 times; After one week, leucorrhea is normal.
Embodiment 2: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 12%
Sodium alginate 0.36%
Glycerol 12%
Gelatin 0.22%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.7%
Cell growth factor 0.012%
Ceramide 0.15%
Laurocapram 0.45%
Oleum menthae 0.65%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, polyhexamethylene guanidine, coenzyme Q10, ceramide, olive oil, almond oil, the skin repair factor, glycerol, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 2
Zhang, female, 30 years old, suffers from vaginitis, and pruritus vulvae, leucorrhoea grow in quantity, leucorrhea become weak yellow foam shape; The gynecological medical biological hydrogel functional dressings of the present embodiment is used to clean vagina, nurse, every day 3 times; After two weeks, leucorrhea is normal; Without pruritus.
Embodiment 3: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9%
Sodium alginate 0.28%
Glycerol 16%
Gelatin 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4%
Cell growth factor 0.009%
Ceramide 0.21%
Laurocapram 0.7%
Oleum menthae 0.45%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 3
Lin, female, 41 years old, suffers from vaginitis, and leucorrhea is mixed with blood or has burning sensation, sexual anhedonia concurrently; Gynecological medical biological hydrogel functional dressings every day of coating the present embodiment 3 times, after one week, leucorrhea is without bloodstain; Continue use 3 weeks, leucorrhea is normal, sexual intercourse is smooth and easy.
Embodiment 4: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 11%
Sodium alginate 0.32%
Glycerol 14%
Gelatin 0.27%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%
Cell growth factor 0.011%
Ceramide 0.18%
Laurocapram 0.55%
Oleum menthae 0.55%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 4:
Lee, female, 35 years old, suffers from Combination vaginitis, the symptoms such as leucorrhoea grow in quantity, urgent micturition, frequent micturition, dysurea, and pudendum has pruritus in various degree and pain, and gynecological medical biological hydrogel functional dressings every day of film the present embodiment 3 times, after one week, urine is normal; Pain slows down; After 3 weeks, leucorrhea is normal, cures, the rehabilitation of Combination vaginitis without pruritus, pain.
Embodiment 5: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 10%
Sodium alginate 0.3
Glycerol 15%
Gelatin 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.2%
Laurocapram 0.6%
Oleum menthae 0.5%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 5:
Zhang, female, 26 years old, suffer from cervicitis, vaginal secretions increases, faint yellow or purulence, postcoital bleeding; Use gynecological medical biological hydrogel functional dressings every day 3 times of the present embodiment, after one week, vaginal secretions is normal; After 3 weeks, cervicitis rehabilitation, cures.
Embodiment 6: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9%
Sodium alginate 0.28%
Glycerol 16%
Gelatin 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4%
Cell growth factor 0.009%
Ceramide 0.21%
Laurocapram 0.7%
Oleum menthae 0.45%
Aloin 0.8%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 6
Lin, female, 42 years old, suffer from candidal vaginitis, vaginal secretions increases, and has a fish like smell, especially sexual intercourse postemphasis, can with slight pruritus vulvae or burning sensation.Use gynecological medical biological hydrogel functional dressings every day 3 times of the present embodiment; After one week, pruritus, burning sensation disappear gradually or weaken; After 3 weeks, vaginal secretions is normal, vagina rehabilitation.
Embodiment 7: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 11%
Sodium alginate 0.32%
Glycerol 14%
Gelatin 0.27%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%
Cell growth factor 0.011%
Ceramide 0.18%
Laurocapram 0.55%
Oleum menthae 0.55%
Aloin 1%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 7
Field, female, 37 years old, suffers from vaginitis; Cervicitis, with mycoplasma clothing body.Use gynecological medical biological hydrogel functional dressings every day 3 times of the present embodiment, after one week, vaginitis rehabilitation, cervicitis alleviates, and mycoplasma clothing Signs shape improves; After two weeks, cervicitis is cured, and mycoplasma clothing Signs shape improves obviously; After 4 weeks, mycoplasma clothing body and pain disappear.
Embodiment 8: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9.8%
Sodium alginate 0.31%
Glycerol 14.5%
Gelatin 0.29%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.53%
Cell growth factor 0.01%
Ceramide 0.19%
Laurocapram 0.65%
Oleum menthae 0.48%
Aloin 0.9%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Case 8: Zhang, female, 52 years old, vaginitis, with cervical erosion.Smear gynecological medical biological hydrogel functional dressings every day 3 times of the present embodiment, after one week, vaginitis is cured, and cervical erosion face is reduced, and after 5 weeks, loses cervical erosion face; Cure.
Embodiment 9:
A kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9%
Sodium alginate 0.28%
Glycerol 14%
Gelatin 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.6%
Cell growth factor 0.011%
Ceramide 0.18%
Laurocapram 0.55%
Oleum menthae 0.45%
Aloin 1%
Hydrogen peroxide 2%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 9: close certain, female, 43 years old, suffers from vaginitis, pruritus vulvae, causalgia, sexual anhedonia.Smear gynecological medical biological hydrogel functional dressings every day 3 times of the present embodiment, after one week, pruritus, causalgia slow down, and after 5 weeks, lose pruritus, causalgia; Sexual intercourse is happy.
Embodiment 10: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 11%
Sodium alginate 0.32%
Glycerol 16%
Gelatin 0.27%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4%
Cell growth factor 0.009%
Ceramide 0.21%
Laurocapram 0.7%
Oleum menthae 0.55%
Aloin 0.8%
Hydrogen peroxide 1%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 10: Zhang, female, 53 years old, suffers from vaginitis; Vaginal secretions increases and thin purulence, yellow green, cystose, frowziness; Pruritus vulvae; Gynecological medical biological hydrogel functional dressings every day of coating the present embodiment 3 times, after one week, pruritus slows down, and stink alleviates; After 6 weeks, vaginal secretions is normal.
Embodiment 11: a kind of gynecological medical biological hydrogel functional dressings, is made up of following material (weight ratio):
Chitosan quaternary ammonium salt 10.5%
Sodium alginate 0.29%
Glycerol 15%
Gelatin 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.2%
Laurocapram 0.6%
Oleum menthae 0.5%
Aloin 0.9%
Hydrogen peroxide 1.5%
Purified water surplus.
A preparation method for above-mentioned gynecological medical biological hydrogel functional dressings, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 11: Zhang, female, 28 years old, suffer from vaginitis, vaginal secretions increases, and has abnormal flavour, postcoital bleeding, can with slight pruritus vulvae or burning sensation.Use gynecological medical biological hydrogel functional dressings every day 3 times of the present embodiment; After one week, pruritus, burning sensation disappear gradually or weaken; After 3 weeks, vaginal secretions is normal.
Below be only the preferred embodiment of the application, equivalent technical solutions on this basis still falls into application protection domain.
Claims (8)
1. a gynecological medical biological hydrogel functional dressings, is characterized in that: be made up of following material (weight ratio):
Chitosan quaternary ammonium salt 7.5 ~ 12%
Sodium alginate 0.21 ~ 0.36%
Glycerol 12 ~ 18%
Gelatin 0.22 ~ 0.35%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.35 ~ 0.7%
Cell growth factor 0.008 ~ 0.012%
Ceramide 0.15 ~ 0.24%
Laurocapram 0.45 ~ 0.75%
Oleum menthae 0.35 ~ 0.65%
Purified water surplus.
2. a kind of gynecological medical biological hydrogel functional dressings according to claim 1, is characterized in that: be made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9 ~ 11%
Sodium alginate 0.28 ~ 0.32%
Glycerol 14 ~ 16%
Gelatin 0.27 ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4 ~ 0.6%
Cell growth factor 0.009 ~ 0.011%
Ceramide 0.18 ~ 0.21%
Laurocapram 0.55 ~ 0.7%
Oleum menthae 0.45 ~ 0.55%
Purified water surplus.
3. a kind of gynecological medical biological hydrogel functional dressings according to claim 1, is characterized in that: be made up of following material (weight ratio):
Chitosan quaternary ammonium salt 10%
Sodium alginate 0.3
Glycerol 15%
Gelatin 0.3%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.5%
Cell growth factor 0.01%
Ceramide 0.2%
Laurocapram 0.6%
Oleum menthae 0.5%
Purified water surplus.
4. a gynecological medical biological hydrogel functional dressings, is characterized in that: be made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9 ~ 11%
Sodium alginate 0.28 ~ 0.32%
Glycerol 14 ~ 16%
Gelatin 0.27 ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4 ~ 0.6%
Cell growth factor 0.009 ~ 0.011%
Ceramide 0.18 ~ 0.21%
Laurocapram 0.55 ~ 0.7%
Oleum menthae 0.45 ~ 0.55%
Aloin 0.8 ~ 1%
Purified water surplus.
5. a gynecological medical biological hydrogel functional dressings, is characterized in that: be made up of following material (weight ratio):
Chitosan quaternary ammonium salt 9 ~ 11%
Sodium alginate 0.28 ~ 0.32%
Glycerol 14 ~ 16%
Gelatin 0.27 ~ 0.32%
Magnesium L-Asacorbic Acid 2-O-Phosphate 0.4 ~ 0.6%
Cell growth factor 0.009 ~ 0.011%
Ceramide 0.18 ~ 0.21%
Laurocapram 0.55 ~ 0.7%
Oleum menthae 0.45 ~ 0.55%
Aloin 0.8 ~ 1%
Hydrogen peroxide 1 ~ 2%
Purified water surplus.
6. a preparation method for the arbitrary described gynecological medical biological hydrogel functional dressings of claims 1 to 3, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
7. a preparation method for gynecological medical biological hydrogel functional dressings according to claim 4, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
8. a preparation method for gynecological medical biological hydrogel functional dressings according to claim 5, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium alginate, glycerol, gelatin, Magnesium L-Asacorbic Acid 2-O-Phosphate, cell growth factor, ceramide, laurocapram, Oleum menthae, aloin, hydrogen peroxide;
Step 2, take the purified water of formula ratio;
Step 3, pours purified water mixing successively into by the formula of step one.
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| CN108567958A (en) * | 2018-07-25 | 2018-09-25 | 杭州光启医疗科技发展有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating gynaecological imflammation |
| CN108926732A (en) * | 2018-09-11 | 2018-12-04 | 佛山科学技术学院 | A kind of carried medicine sustained-release aerogel dressing suitable for diabetic foot care |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
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| CN105013001B (en) | 2018-03-06 |
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