CN105107007A - Cationic medical wound protecting dressing and method for preparing same - Google Patents
Cationic medical wound protecting dressing and method for preparing same Download PDFInfo
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- CN105107007A CN105107007A CN201510529235.4A CN201510529235A CN105107007A CN 105107007 A CN105107007 A CN 105107007A CN 201510529235 A CN201510529235 A CN 201510529235A CN 105107007 A CN105107007 A CN 105107007A
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Abstract
The invention relates to the technical field of skin nursing, in particular to cationic medical wound protecting dressing and a method for preparing the same. The cationic medical wound protecting dressing comprises, (by weight), 1.2-1.8% of quaternary ammonium salt of chitosan, 1-1.3% of sodium chloride, 0.1-0.3% of sodium carboxymethyl cellulose, 1-3% of hyaluronic acid, 0.07-0.15% of puffball, 0.35-0.65% of coenzymes Q10, 0.25-0.4% of ceramide and the balance water for injection. The cationic medical wound protecting dressing and the method have the advantages that post-traumatic tissue wound surfaces, mucosas and skins can be protected; purposes of stopping bleeding, reducing oozing of tissue fluid and protecting, lubricating and isolating the tissue wound surfaces can be achieved; antibacterial, sterilization and wound surface healing promotion effects can be realized by the cationic medical wound protecting dressing; the skins can be quickly repaired without scar.
Description
Technical field
The present invention relates to technique in skin care field, particularly relate to medical the protecting of a kind of cation and create dressing and preparation method thereof.
Background technology
After surgery, health upper epidermis all can leave operation wound, and post-traumatic skin needs cleaning, and current great majority only carry out disinfection sterilization processing, as adopted medical alcohol to disinfect, then binds gauze; This processing mode, can have a lot of injury to wound face, wound face has anaerobic bacteria to assemble, and usually causes wound face ulcer, loses scar.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, provide medical the protecting of a kind of cation to create dressing and preparation method thereof, can nurse wound site, to the isolation of antibacterial, fungus, virus; Make wound site Fast Restoration; And can avoid leaving scar.
For achieving the above object, the technical solution used in the present invention is:
A kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.2 ~ 1.8%
Sodium chloride 1 ~ 1.3%
Sodium carboxymethyl cellulose 0.1 ~ 0.3%
Hyaluronic acid 1 ~ 3%
Lasiosphaera Seu Calvatia 0.07 ~ 0.15%
Coenzyme Q10 0.35 ~ 0.65%
Ceramide 0.25 ~ 0.4%
Water for injection surplus.
Water instant cation chitosan quaternary ammonium salt has the performances such as good antibiotic property, film property, cation-adsorption, moisture absorbability and moisture retentivity, flocculability, antistatic behaviour.Its anti-microbial property is better than chitosan and other chitosan derivatives.After chitosan quaternary ammonium salt is water-soluble, ionize, containing a large amount of level Four ammonium cations in solution.Ammonium cation has certain fragmentation effect to antibacterial, fungus, virus.
Sodium chloride concentration, higher than the physiological concentration of people, can kill antibacterial and fungus by osmotic pressure.Colonize in the antibacterial of human body skin wound surface, its Cytoplasm concentration is suitable with Human Physiology concentration; Sodium chloride concentration, higher than bacterial cytoplasm concentration, just can kill antibacterial.
Sodium carboxymethyl cellulose is in the purposes of pharmaceuticals industry: the emulsion stabilizer can making injection in medical industry, the binding agent of tablet and film former.Through basis and zoopery, someone proves that sodium carboxymethyl cellulose is safe and reliable anticarcinogen carrier.Make membrane material with sodium carboxymethyl cellulose, transformation dosage form---the Use of " Yangyinshengji ", Film as Wound Dressing of the Chinese medicine nourishing yin shengjisan of development, dermabrasion surgical wound surface and traumatic wound surface can be used for.Research of Animal Model for Study shows, this film prevents traumatic infection, and with gauze dressing no significant difference, ooze out with on wound surface quickly-healing at control wound tissue liquid, this film is obviously better than gauze dressing, and has and alleviate postoperative edema and wound surface stimulation.With polyvinyl alcohol: sodium carboxymethyl cellulose: carbopol is best prescription in the membrane that the ratio of 3:6:1 is made, adhesiveness and rate of release all increase, increasing the adhesion of mucosal adhesive sustained release film formulation, extending preparation and be all significantly improved in the drug effect of intraoral holdup time and preparation of Chinese medicine.
Sodium carboxymethyl cellulose can be used as the hydrosol and thickening agent.
Hyaluronic acid is a kind of acid mucopolysaccharide, and first Columbia Univ USA ophthalmology professor Meyer in 1934 etc. isolate this material from bovine vitreous body.Hyaluronic acid demonstrates multiple important physiological function with the molecular structure of its uniqueness and physicochemical property in body, as lubricating joint, regulates the permeability of blood vessel wall, Function protein matter, and Water-Electrolyte diffusion and running, promote wound healing etc.Significantly, hyaluronic acid has special water retention, it is the best material of the occurring in nature moisture retention that finds at present, be called as desirable nature moisturizing factor (Naturalmoisturizingfactor, NMF, such as: the pure hyaluronic acid aqueous solution of 2% can keep 98% moisture securely.Hyaluronic acid is a kind of multi-functional substrate, and hyaluronic acid (hyaluronic acid) HA is distributed widely in partes corporis humani position.Wherein skin is also containing a large amount of hyaluronic acids.Human skin maturation and ageing process also change along with hyaluronic content and metabolism, it can improve skin-nourishing metabolism, make that skin is tender, smooth, wrinkle removing, increase elasticity, prevent aging, be again good Percutaneous absorption enhancer while moisturizing.With other nutritional labelings with the use of, can play and promote the better effect of alimentation.
Hyaluronic acid itself, with negative charge, is present in most soft connective tissue at animal body.Its aqueous solution is viscoelastic fluid, to be filled among cell and collagen fiber space and to cover in some epidermal tissue.At animal body, its major function is protection and lubricant cell, regulates the movement of cell on this viscoelastic ground substance, stablizes collagen meshwork and protect it to avoid being subject to mechanical destruction.Because hyaluronic acid is natural sex lubrication and shock-absorbing macromolecule, on tendon, tendon sheath and stick-slip film surface as lubricant.Hyaluronic acid (hyaluronic acid) HA is distributed widely in the connective tissue of human body, almost exists with pure form in bovine vitreous body, articular cavity.Be present in hyaluronic acid (hyaluronic acid) HA in skin, important effect is played to the metabolism of human epidermal.In human body, the destruction of hyaluronic acid (hyaluronic acid) HA or imbalance, all can cause disease.In skin, the minimizing of hyaluronic acid (hyaluronic acid) HA content and destruction, can cause in skin dehydration, wrinkling and follow the string, and makes people's epidermis old and feeble, and thus, hyaluronic acid (hyaluronic acid) HA is otherwise known as the defying age factor.
Hyaluronic acid (hyaluronic acid) HA is one of main matrix composition of application on human skin epidermis and corium; its physiological function to make moisture enter intercellular substance; and form protein gel with protein bound, and cell is sticked together, the cellular metabolism effect of bringing into normal play; play and keep cell moisture; Cell protection, not by the infringement of pathogen, is accelerated to recover skin histology, is improved wound healing regeneration capacity; reduce cicatrix, the effects such as enhancing immunity.Meanwhile, hyaluronic acid is the main component of proliferative cell and migrating cell extracellular matrix, is especially like this in embryonal tissue.Because self characteristic hyaluronic, cell can be made to keep separated from one another, make cell be easy to motion migration and breed and stop cell differentiation.In growth course, hyaluronic effect seemingly prevent cell propagation enough or migration put in place before break up too early.In medical, hyaluronic acid (hyaluronic acid) HA is used for non-steroid antiinflammatory drug, arthritis treatment, ophthalmology, the paramedicines of cardiac surgery operation, in treatment scald, burn, cold injury, artificial skin etc., has original effect.
Large quantity research shows, human body skin top layer (horny layer) moisture accounts for 15-30%, all makes people uncomfortable, have dry sense or soapy feeling, for a long time so, can make chapped skin or edema, thus skin is followed the string below or above this value, coarse aging.And hyaluronic acid (hyaluronic acid) HA act on skin inside conditioning after, automatically can regulate in different environments, maintain moisture of skin all the time at 25-30%, keep the moistening, salubrious of skin, make skin more high resilience, play crease-resistant wrinkle resistant, the effect that delays the full skin aging of people, looks improving and the skin nourishing.Hyaluronic acid is wherein a kind of composition of human body skin corium, possesses the ability keeping moisture content, deal is more up to 100 times of itself weight, use the skin care products containing hyaluronic acid HA, the dry skin with having there is wrinkle can be improved, make it recover original smooth and elasticity, therefore, hyaluronic acid is the most ideal product improving dry and aged skin.
Hyaluronic acid (hyaluronic acid) HA can also improve skin growth condition, and for the synthesis of dermal collagen and elastic fiber provides superior external environment condition, the supply of reinforced nutrition matter, plays the effect of skin-protecting face nursing.Research shows, hyaluronic acid HA can stop the generation of some enzymes in cell, reduce the formation of free radical, destroy cellularity preventing free radical, produce lipid peroxidation and cause the important roles such as senility of humanbody: low-molecular-weight hyaluronic acid has antiinflammatory, suppresses pathogenic bacteria to produce, keeps the effect that skin is bright and clean; For cell proliferation and differentiation provide suitable place, direct Promote cell's growth, differentiation, reconstruction and reparation etc.
Lasiosphaera Seu Calvatia has 1. anastalsises: lasiosphaera fenzlii Reics has to oral cavity hemorrhagic illness usefulness of significantly stopping blooding, not second to starch sponge or gelfoam, also effective to epistaxis.Principle is not bright.2. antibacterial action: in vitro tests, lasiosphaera fenzlii Reics decoct has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus and Diplococcus pneumoniae, also has inhibitory action to minority pathomycete.Containing a large amount of pigment in decoct, through with after activated carbon decolorizing, antibacterial action subtracts greatly.The squeezing juice of the new fresh sporophore of dust gill fungus, to animal injection, can poison blood capillary, cause visceral hemorrhage.
Coenzyme Q10 is a kind of fat-soluble antioxidant, the nutrition of energy human activin cell and cellular energy, there is functions such as improving body immunity, enhancing antioxidation, slow down aging and enhancing human activity, medically be widely used in cardiovascular system diseases, extensively use it for nutrient and healthcare products and food additive both at home and abroad.Coenzyme Q10 (CoenzymeQ10), also known as ubiquinone (Ubiquinone, abbreviation UQ), is that one is present in natural fat-soluble quinones, and its structure and vitamin K, vitamin E are similar to plastoquinone.In human body cell, participate in energy manufacture and activation, be that prevention of arterial sclerosis forms the most effective antioxidation composition.Ubiquinone is present in most eukaryotic cell, especially mitochondrion.It is one of respiratory chain component; Its content on mitochondrial inner membrane is far away higher than the content of other components of respiratory chain, and the fat-soluble mobility making it have height on inner membrance, is particularly suitable as a kind of electron transit mediator of flowing.
Coenzyme Q10 mainly contains two effects in vivo, and one is be converted in the process of energy at nutrient substance to play an important role in mitochondrion, and two is have obvious lipoid peroxidization resistant.It is the power conversion agent in cell mitochondrial, and it produces ATP(adenosine triphosphate by shifting and transmit electronics participation " tricarboxylic acid cycle "), namely energy factors is for cellular metabolism.Coenzyme Q10 is effective antioxidant and free radical scavenger, it is embedded in mitochondrial inner membrane lipid bilayer as the ingredient of mitochondrial respiratory chain, alcohol of formula is become after 2 electronics that Mitochondria complex I or complex II accepts, then by electron transmission to complex III.Body coenzyme Q 10 is become alcohol of formula by a large amount of consumption, and it is effective antioxidant, and be also the electron carrier of motion, hydrogen atom is given to lipid peroxidation free radical from its hydroxyl by it simultaneously, thus reduces the lipid peroxide reaction of mitochondrial inner membrane.Generate the out-of-proportion free radical ubisemiquinone of alcohol of formula with coenzyme Q10 and coenzyme Q10 in the process, or to react formation superoxides with oxygen, free radical ubisemiquinone is transported free radical and is realized Detoxication under superoxide dismutase and catalatic effect, the respiratory chain that so moves in circles, by continuous for coenzyme Q10 regeneration alcohol of formula, has recovered its antioxidant activity effect.
Ceramide, also known as sphingolipid, is a kind of lipid being present in skin, plays an important role in epidermal keratinocytes layer formation process.When drying, desquamation, cracking phenomena appear in skin, when its barrier function obviously reduces, skin supplements ceramide can recover rapidly moisturizing and barrier function.
Cause xerosis cutis main cause to be that in horny layer of epidermis, ceramide content reduces, ceramide content height is directly related with skin dryness.Use ceramide can obviously strengthen adhesion strength between keratinocyte, improve skin dryness, reduce desquamation phenomenon.Ceramide has very strong associated water molecule ability, and it maintains moisture of skin by forming network structure in horny layer.Therefore, ceramide has the effect of maintenance moisture of skin.Use ceramide that ceramide content in horny layer of epidermis can be made to increase, xerosis cutis, desquamation, the situation such as coarse can be improved; Ceramide can increase epidermal keratinocytes layer thickness simultaneously, improves skin moisture holding capacity, reduces wrinkle, strengthens skin elasticity, delay skin aging.
Ceramide is a kind of water-soluble grease metallic substance, and it is close with the structure of matter forming keratodermatitis, can penetrate into skin very soon, and the water in horny layer combines, and forms a kind of network structure, pins moisture.
The medical preparation method of protecting wound dressing of a kind of above-mentioned cation: comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
In use, main employing processes the mode that wound surface rinses in the dressing of the application.Chitosan quaternary ammonium salt in dressing mainly plays the effect of sterilization, sterilization, hemostasis, anti; Sodium chloride mainly plays the effect of sterilization, sterilization, flushing; Sodium carboxymethyl cellulose, hyaluronic acid mainly play anti; Lasiosphaera Seu Calvatia mainly plays the effect of hemostasis; Ceramide plays antianaphylactic effect; Coenzyme Q10 plays antioxidative effect.
Preferably, a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4 ~ 1.6%
Sodium chloride 1 ~ 1.2%
Sodium carboxymethyl cellulose 0.15 ~ 0.25%
Hyaluronic acid 1.8 ~ 2.2%
Lasiosphaera Seu Calvatia 0.08 ~ 0.12%
Coenzyme Q10 0.45 ~ 0.55%
Ceramide 0.28 ~ 0.35%
Water for injection surplus.
Again preferably, a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.2%
Hyaluronic acid 2%
Lasiosphaera Seu Calvatia 0.1%
Coenzyme Q10 0.5%
Ceramide 0.3%
Water for injection surplus.
More preferably, a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4 ~ 1.6%
Sodium chloride 1 ~ 1.2%
Sodium carboxymethyl cellulose 0.15 ~ 0.25%
Hyaluronic acid 1.8 ~ 2.2%
Lasiosphaera Seu Calvatia 0.08 ~ 0.12%
Coenzyme Q10 0.45 ~ 0.55%
Ceramide 0.28 ~ 0.35%
Aloin 0.8 ~ 1%
Water for injection surplus.
Aloin can help to discharge dirt in body, purifies the blood, vessel softening, reduces blood pressure and blood viscosity, blood circulation promoting; The mixture of active component based on barbaloin is dicotyledon Aloe extract.Bactericidal action, antiinflammatory action, moistening beautification function, lets out effect under stomach invigorating, the heart tonifying effect of invigorating blood circulation, immunity and regeneration, immunity and antitumor action, Detoxication, anti-aging effects, analgesia, sedation, anti-sunlight function.The polysaccharide contained in Aloe and multivitamin have good nutrition, moist, whitening effect to human body skin.Aloe Barbadensis Miller is the Fresh leaf of aloe that optimum is directly improved looks, i.e. Aloe vulgaris, and it has the performance making skin contraction, softnessization, moisturizing, antiinflammatory, bleaching.Remove sclerosis, keratinization in addition, improve the effect of scar, little wrinkle, eye pouch, cutis laxa can not only be prevented, skin wet, tender and lovely can also be kept, simultaneously, can also scytitis be treated, also have good curative effect to acne, freckle, acne and scald, knife injury, insect bite etc.Effective too to hair, hair can be made to keep moistening smooth, pre-Anti-hair loss.
When skin is subject to wound, sometimes along with hemorrhage; Also can along with inflammation; In dressing, increase a certain amount of aloin, certain haemostatic effect and antibacterial, antiinflammatory can be played; By clinical trial, do not conflict with other drug composition.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Further preferably, a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4 ~ 1.6%
Sodium chloride 1 ~ 1.2%
Sodium carboxymethyl cellulose 0.15 ~ 0.25%
Hyaluronic acid 1.8 ~ 2.2%
Lasiosphaera Seu Calvatia 0.08 ~ 0.12%
Coenzyme Q10 0.45 ~ 0.55%
Ceramide 0.28 ~ 0.35%
Aloin 0.8 ~ 1%
Hydrogen peroxide 1 ~ 2%
Water for injection surplus.
Hydrogen peroxide has good oxidation effectiveness, when adopting the wound of the hydrogen peroxide of low concentration (especially weight ratio is lower than 3%) and skin, pus or dirt to meet, decomposes immediately and generates oxygen.This oxygen atom being not yet combined into oxygen molecule, has very strong oxidability, when contacting with antibacterial, can destroy microorganism, kill antibacterial.Can provide an aerobic environment, the collagen protein killing anaerobe and aid in skin is formed simultaneously.Here the content of hydrogen peroxide refers to the weight content of hydrogen peroxide in whole dressing: 1% ~ 2%.Here hydrogen peroxide content is the content of pure hydrogen peroxide.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin, hydrogen peroxide;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Beneficial effect of the present invention is: protect and post-traumaticly organize wound surface, mucosa and skin; Play hemostasis, reduce oozing out of tissue fluid, protection, lubrication, separating tissues wound surface; And have antibacterial, sterilization, wound healing effect.Fast skin reparation can be reached, and do not leave scar.
Detailed description of the invention
Below the present invention is described further.
Embodiment 1: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.2%
Sodium chloride 1.3%
Sodium carboxymethyl cellulose 0.1%
Hyaluronic acid 3%
Lasiosphaera Seu Calvatia 0.07%
Coenzyme Q10 0.65%
Ceramide 0.25%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 1:
Huang, man, 15 years old, arm was scalded by boiled water, and wound suppurates on a large scale, and after wound cleaning, medical the protecting of cation of smearing the present embodiment creates dressing one month, every day 3 times; Wound healing, and substantially without scar.
Embodiment 2: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.8%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.3%
Hyaluronic acid 1%
Lasiosphaera Seu Calvatia 0.15%
Coenzyme Q10 0.35%
Ceramide 0.4%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 2
Zhang, female, 30 years old, after arm is operated on, wound surface was comparatively large, and wound surface in a organized way liquid oozes out; The cation of coating the present embodiment is medical protects wound dressing 3 weeks, every day 3 times, and wound takes a turn for the better, and inorganization liquid oozes out; New skin tissue growth; Continue use 4 weeks again, wound healing, without obvious scar.
Embodiment 3: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.3%
Sodium chloride 1.1%
Sodium carboxymethyl cellulose 0.18%
Hyaluronic acid 2.3%
Lasiosphaera Seu Calvatia 0.09%
Coenzyme Q10 0.4
Ceramide 0.33%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 3
Lin, man, 34 years old, fall down by motorcycle, injury organizes sepage, and pigementation appears in trauma skin periphery; The cation of coating the present embodiment is medical protects wound dressing one week, every day at least 3 times, and sepage place starts abatement; Continue use 3 weeks, pigment disappears, wound healing.
Embodiment 4: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4%
Sodium chloride 1.2%
Sodium carboxymethyl cellulose 0.21%
Hyaluronic acid 2.1%
Lasiosphaera Seu Calvatia 0.11%
Coenzyme Q10 0.52%
Ceramide 0.32%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 4:
Lee, man, 35 years old, thigh ocal resection; Surgical wound surface starts to have ulcer sign and with inflammation; After the cleaning of wound portion, the cation of film the present embodiment is medical protects wound dressing one week, every day 3 times, and inflammation starts abatement, new skin tissue growth; Cure after 4 weeks.
Embodiment 5: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.2%
Hyaluronic acid 2%
Lasiosphaera Seu Calvatia 0.1%
Coenzyme Q10 0.5%
Ceramide 0.3%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 5
Zhang, man, 45 years old, is hurt by cutter, and wound surface is comparatively large, and wound surface is hemorrhage; Through normal oozing of blood after bandage; Use the medical wound dressing that protects of the cation of the present embodiment to apply at least 3 times every day, after one week, depletion of blood oozes out; And window starts to scab, wound healing after 4 weeks.
Embodiment 6: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.25%
Hyaluronic acid 2.2%
Lasiosphaera Seu Calvatia 0.08%
Coenzyme Q10 0.45%
Ceramide 0.35%
Aloin 1%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 6
Lin, man, 32 years old, fall down gaskin scratch, bleed in the middle part of wound face in running, wound face periphery in a organized way liquid oozes out, and uses the medical wound dressing that protects of the cation of the present embodiment to rinse, stops blooding then and there, start to scab; Every day rinses at least 3 times, and after 2 days, inorganization liquid oozes out; Wound healing after 4 weeks.
Embodiment 7: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.6%
Sodium chloride 1.2%
Sodium carboxymethyl cellulose 0.15%
Hyaluronic acid 1.8%
Lasiosphaera Seu Calvatia 0.12%
Coenzyme Q10 0.55%
Ceramide 0.28%
Aloin 0.8%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 7
Field, female, 41 years old, is made with heart valve surgery; Wound place often in a organized way liquid ooze out, use that the cation of the present embodiment is medical protects wound dressing every day 3 times, after one week, inorganization liquid oozes out; After 4 weeks, wound healing.
Embodiment 8: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.55%
Sodium chloride 1.15%
Sodium carboxymethyl cellulose 0.19%
Hyaluronic acid 1.9%
Lasiosphaera Seu Calvatia 0.10%
Coenzyme Q10 0.51%
Ceramide 0.31%
Aloin 0.9%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin, hydrogen peroxide;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Case 8: Zhang, female, 12 years old, arm was burned, and epidermis is liquid, blister in a organized way; After wound cleaning, smear that the cation of the present embodiment is medical protects wound dressing, wound scabs, and after one week, wound starts healing, new skin tissue growth, and pigementation appears in wound perimeter; After 4 weeks, wound healing; Pigment disappears; Without cicatrix.
Embodiment 9:
A kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.15%
Hyaluronic acid 2.2%
Lasiosphaera Seu Calvatia 0.12%
Coenzyme Q10 0.55%
Ceramide 0.28%
Aloin 0.8%
Hydrogen peroxide 1%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin, hydrogen peroxide;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 9: close certain, man, 10 years old, falls down skin and be scratched, and part wound is darker; After wound cleaning, the cation of coating the present embodiment is medical protects wound dressing, and wound starts to scab, healing after a week; Without Infective morbidity; And without obvious cicatrix.
Embodiment 10: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.6%
Sodium chloride 1.2%
Sodium carboxymethyl cellulose 0.25%
Hyaluronic acid 1.8%
Lasiosphaera Seu Calvatia 0.08%
Coenzyme Q10 0.45%
Ceramide 0.35%
Aloin 1%
Hydrogen peroxide 1.5%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin, hydrogen peroxide;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 10: Zhao, man, 9 years old, slips and falls, gouge knee joint lid; The outside oozing of blood of skin histology and tissue fluid, after the cleaning of wound mouth; The cation of coating the present embodiment is medical protects wound dressing, stops blooding, scab after one hour; And inorganization liquid stream goes out; Apply 3 every day, after 3 weeks, fall scar, without scar and without bacteriological infection, wound healing.
Embodiment 11: a kind of cation is medical protects wound dressing, is made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.2%
Hyaluronic acid 2%
Lasiosphaera Seu Calvatia 0.1%
Coenzyme Q10 0.5%
Ceramide 0.3%
Aloin 1%
Hydrogen peroxide 2%
Water for injection surplus.
The medical preparation method of protecting wound dressing of above-mentioned cation, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin, hydrogen peroxide;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
Because content 100% hydrogen peroxide is difficult to obtain, the hydrogen peroxide of the quality such as the hydrogen peroxide employing in step one, other concentration hydrogen peroxide substitute; I.e. step one, join get hydrogen peroxide time, other concentration hydrogen peroxide getting equivalent can being joined, getting 30% hydrogen peroxide (quality containing hydrogen peroxide is equal) of equal size hydrogen peroxide as joined; Step 2 replaces with: the purified water taking surplus.
Case 11: Zhang, man, 15 years old, be wound by firecrackers; Site of injury is bled incessantly, and the cation of coating the present embodiment is medical protects wound dressing, stops blooding and start to scab after 5 minutes; Apply 3 every day, fall scar after 3 weeks and without cicatrix.
Below be only the preferred embodiment of the application, equivalent technical solutions on this basis still falls into application protection domain.
Claims (8)
1. cation is medical protects a wound dressing, it is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.2 ~ 1.8%
Sodium chloride 1 ~ 1.3%
Sodium carboxymethyl cellulose 0.1 ~ 0.3%
Hyaluronic acid 1 ~ 3%
Lasiosphaera Seu Calvatia 0.07 ~ 0.15%
Coenzyme Q10 0.35 ~ 0.65%
Ceramide 0.25 ~ 0.4%
Water for injection surplus.
2. a kind of cation according to claim 1 is medical protects wound dressing, it is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4 ~ 1.6%
Sodium chloride 1 ~ 1.2%
Sodium carboxymethyl cellulose 0.15 ~ 0.25%
Hyaluronic acid 1.8 ~ 2.2%
Lasiosphaera Seu Calvatia 0.08 ~ 0.12%
Coenzyme Q10 0.45 ~ 0.55%
Ceramide 0.28 ~ 0.35%
Water for injection surplus.
3. a kind of cation according to claim 1 is medical protects wound dressing, it is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.5%
Sodium chloride 1%
Sodium carboxymethyl cellulose 0.2%
Hyaluronic acid 2%
Lasiosphaera Seu Calvatia 0.1%
Coenzyme Q10 0.5%
Ceramide 0.3%
Water for injection surplus.
4. cation is medical protects a wound dressing, it is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4 ~ 1.6%
Sodium chloride 1 ~ 1.2%
Sodium carboxymethyl cellulose 0.15 ~ 0.25%
Hyaluronic acid 1.8 ~ 2.2%
Lasiosphaera Seu Calvatia 0.08 ~ 0.12%
Coenzyme Q10 0.45 ~ 0.55%
Ceramide 0.28 ~ 0.35%
Aloin 0.8 ~ 1%
Water for injection surplus.
5. cation is medical protects a wound dressing, it is characterized in that: be made up of following raw material (weight ratio):
Chitosan quaternary ammonium salt 1.4 ~ 1.6%
Sodium chloride 1 ~ 1.2%
Sodium carboxymethyl cellulose 0.15 ~ 0.25%
Hyaluronic acid 1.8 ~ 2.2%
Lasiosphaera Seu Calvatia 0.08 ~ 0.12%
Coenzyme Q10 0.45 ~ 0.55%
Ceramide 0.28 ~ 0.35%
Aloin 0.8 ~ 1%
Hydrogen peroxide 1 ~ 2%
Water for injection surplus.
6. the medical preparation method of protecting wound dressing of the arbitrary described cation of claims 1 to 3: comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
7. the medical preparation method of protecting wound dressing of cation according to claim 4, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
8. the medical preparation method of protecting wound dressing of cation according to claim 5, comprising:
Step one, the chitosan quaternary ammonium salt taking formula ratio, sodium chloride, sodium carboxymethyl cellulose, hyaluronic acid, Lasiosphaera Seu Calvatia, ceramide, coenzyme Q10, aloin, hydrogen peroxide;
Step 2, take the water for injection of formula ratio;
Step 3, pours water for injection mixing successively into by the formula of step one.
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| CN105457077A (en) * | 2016-01-22 | 2016-04-06 | 广西信业生物技术有限公司 | Novel composite biological fiber hemostatic powder material and preparation method thereof |
| CN105641737A (en) * | 2016-01-22 | 2016-06-08 | 广西信业生物技术有限公司 | Porous fiber medical biological hemostatic material and preparation method thereof |
| CN105641738A (en) * | 2016-01-22 | 2016-06-08 | 广西信业生物技术有限公司 | Novel biofiber hemostatic material and preparing method thereof |
| CN108125979A (en) * | 2017-12-29 | 2018-06-08 | 广州润虹医药科技股份有限公司 | A kind of composition with sterilization defencive function and its application |
| CN108403908A (en) * | 2018-04-20 | 2018-08-17 | 江西金思康药业有限公司 | A kind of wound healing dressing of skin-friendly and preparation method thereof |
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| CN108968172A (en) * | 2018-06-18 | 2018-12-11 | 广东欣薇尔服装有限公司 | A kind of preparation method of health care underwear |
| CN108837186A (en) * | 2018-06-21 | 2018-11-20 | 东莞市联洲知识产权运营管理有限公司 | A kind of preparation method of medical material of the surface coated with antimicrobial coating |
| CN111249179A (en) * | 2020-03-18 | 2020-06-09 | 成都斯瑞宁科技有限公司 | Mask with medical function |
| CN114432485A (en) * | 2022-02-15 | 2022-05-06 | 周建大 | pH-responsive quaternary ammonium salt antibacterial dressing and preparation method thereof |
| CN115350202A (en) * | 2022-09-13 | 2022-11-18 | 浙江中医药大学 | Application of puffball polysaccharide in preparation of medicine for preventing and treating wound |
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Address after: 523000, Guangdong City, Dongguan province Sanyuanli community finance business building, two floor, No. 205-208, Dongguan City Da Qing Medical Equipment Co., Ltd. Patentee after: DONGGUAN DAQING MEDICAL DEVICES Co.,Ltd. Patentee after: GUANGXI DAQING BIOLOGICAL SCIENCE & TECHNOLOGY Co.,Ltd. Patentee after: GUANGXI XINYE BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: 523000, Guangdong City, Dongguan province Sanyuanli community finance business building, two floor, No. 205-208, Dongguan City Da Qing Medical Equipment Co., Ltd. Patentee before: DONGGUAN DAQING MEDICAL DEVICES Co.,Ltd. Patentee before: GUANGXI DAQING BIOTECHNOLOGY Co.,Ltd. Patentee before: GUANGXI XINYE BIOLOGICAL TECHNOLOGY Co.,Ltd. |