CN113117137A - Medical dressing containing recombinant human collagen and preparation method thereof - Google Patents
Medical dressing containing recombinant human collagen and preparation method thereof Download PDFInfo
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- CN113117137A CN113117137A CN202110423534.5A CN202110423534A CN113117137A CN 113117137 A CN113117137 A CN 113117137A CN 202110423534 A CN202110423534 A CN 202110423534A CN 113117137 A CN113117137 A CN 113117137A
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
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- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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Abstract
The invention discloses a medical dressing containing recombinant human collagen, which consists of the following raw materials in percentage by weight: 0.5-1.5% of recombinant human collagen, 3-7% of ceramide, 2-6% of nicotinamide, 0.6-1% of medical chitosan, 0.5-1.5% of ginseng extract, 0.2-0.6% of chamomile extract, 0.3-0.7% of purslane extract, 0.1-0.5% of aloe extract, 0.1-0.3% of natural lactic acid, 0.1-0.5% of polyhexamethylene biguanide, 0.3-0.7% of carbomer, 3-7% of propylene glycol, 1-5% of glycerol, 0.05-0.15% of triethanolamine and the balance of purified water; the invention also provides a preparation method of the medical dressing containing the recombinant human collagen. The medical dressing has the performances of antibacterial repair, high biocompatibility and strong cell affinity, has excellent functions of water permeation, air permeation, moisture absorption, wound infection reduction and wound pain rapid relief, and has the effects of wound repair, aging skin tightening and anti-aging, water replenishing, anti-allergy and skin beautifying on human skin; it can also be used for female vulva and vagina for antibacterial, cleaning, antiaging, and repairing, and promoting vaginal health.
Description
Technical Field
The invention relates to the technical field of medical dressings, in particular to a medical dressing containing recombinant human collagen and a preparation method thereof.
Background
The medical dressing in the traditional concept refers to a medical material used for covering sores, wounds or other skin injuries, and a series of problems of organisms can be caused after skin is injured by wounds, burns, abscess festers and the like, such as bacterial infection, excessive loss of moisture and protein, endocrine and immune dysfunction and the like, and serious life can be endangered.
Clinically, the mode that medical glue is coated on fixed pad pasting is mostly adopted in current dressing to fix on skin, and the mode of full width coating is usually adopted to coat medical glue on fixed pad pasting, and is not convenient for use, and it has certain irritability to skin, and especially some sensitive skin more can cause the allergy, are unfavorable for the recovery in affected part, so need improve.
Disclosure of Invention
The invention aims to solve the problems that the existing dressings are mostly fixed on skin by coating medical adhesive on a fixed sticking film, the medical adhesive is usually coated on the fixed sticking film to be inconvenient to use and the like, and the dressing has certain irritation on the skin, particularly, sensitive skin can cause allergy and is not beneficial to the recovery of affected parts, and provides the medical dressing containing the recombinant human collagen and the preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a medical dressing containing recombinant human collagen is composed of the following raw materials in percentage by weight:
0.5 to 1.5 percent of recombinant human collagen
3 to 7 percent of ceramide
2 to 6 percent of nicotinamide
Medical chitosan 0.6-1%
Ginseng extract 0.5-1.5%
0.2 to 0.6 percent of chamomile extract
0.3 to 0.7 percent of purslane extract
0.1-0.5% of aloe extract
0.1 to 0.3 percent of natural lactic acid
0.1-0.5 thousandth of polyhexamethylene biguanide
Carbomer 0.3% -0.7%
3 to 7 percent of propylene glycol
1 to 5 percent of glycerin
0.05 to 0.15 percent of triethanolamine
The remainder was purified water.
Preferably, the material composition comprises the following raw materials in percentage by weight:
1 percent of recombinant human collagen
Ceramide 5%
4 percent of nicotinamide
Medical chitosan 0.8%
Ginseng radix extract 1%
Chamomile extract 0.4%
0.5 percent of purslane extract
Aloe extract 0.3%
0.2 percent of natural lactic acid
0.3 per mill of polyhexamethylene biguanide
Carbomer 0.5%
Propylene glycol 5%
3 percent of glycerin
0.1 percent of triethanolamine
The remainder was purified water.
Preferably, the recombinant human collagen is a high molecular biological protein produced by reverse transcription of mRNA of human collagen into cDNA by a bioengineering technology, enzyme digestion of a section of gene recombination and high-density fermentation, separation, renaturation and purification processes in escherichia coli; the ceramide is a phospholipid with ceramide as a skeleton, and mainly comprises ceramide phosphorylcholine and ceramide phosphorylethanolamine; said nicotinamide is a derivative of vitamin B3; the medical chitosan has an inhibiting effect on the growth of various bacteria; the ginseng extract is warm in nature, sweet in taste, slightly bitter and slightly warm; the chamomile extract is bitter, pungent and slightly cold in physical property, has the effects of clearing heat and eliminating dampness, and has the functions of resisting bacteria, diminishing inflammation and relieving pain; the herba Portulacae extract has sour and cold physical properties and effects of clearing heat and detoxicating, cooling blood and stopping bleeding, and stopping dysentery; the aloe extract is bitter in taste and cold in nature; the purified water is water having a resistivity of greater than 0.1x106 Ω cm at a temperature of greater than 25 ℃.
Preferably, the nicotinamide is a white crystalline powder, odorless or almost odorless, bitter in taste, slightly hygroscopic.
Preferably, the polyhexamethylene biguanide is a colorless to light amber solution, and the polyhexamethylene biguanide is a derivative of a high molecular polymer as a main disinfecting and sterilizing component.
Preferably, the carbomer is a white loose powder and has a characteristic slight odor, and the carbomer is a high molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether.
Preferably, the propylene glycol is a colorless, slightly viscous and sweet liquid, the glycerol is colorless, odorless, sweet and clear and viscous in appearance, and the triethanolamine is a colorless to light yellow transparent viscous liquid with slight ammonia odor and becomes colorless to light yellow cubic crystals at low temperature.
The invention also provides a preparation method of the medical dressing containing the recombinant human collagen, which comprises the following steps:
s1, slowly adding the uniformly mixed medical chitosan, carbomer, glycerol and propylene glycol into water while stirring, heating to 80-85 ℃, and continuously stirring until the medical chitosan and the carbomer are completely dissolved to obtain a first mixed solution;
s2, cooling the first mixed solution to 40-45 ℃, adding recombinant human collagen, ceramide, nicotinamide, ginseng extract, chamomile extract, purslane extract and aloe extract into the first mixed solution, fully and uniformly stirring, and filtering with 200-mesh filter cloth to obtain a second mixed solution;
s3, adding polyhexamethylene biguanide and natural lactic acid into the second mixed solution, and fully and slowly stirring uniformly to obtain a mixture;
s4, adding the balance of purified water into the mixture, adding triethanolamine, and stirring uniformly;
and S5, vacuumizing, stirring uniformly, and removing bubbles.
The invention has the beneficial effects that:
1. through the matching of various materials such as recombinant humanized collagen, ceramide, nicotinamide, medical chitosan, a ginseng extract, a chamomile extract, a purslane extract, an aloe extract, natural lactic acid and the like, the skin-friendly property of the dressing can be well improved, a protective film can be well formed, moisture and nutrient substances can be effectively supplemented into skin, the quality of skin cells can be favorably improved, the effects of water and skin whitening, deep purification, epidermis repair, skin awakening and aging resistance, skin beautifying nutrition, anti-allergy skin beautifying and the like can be achieved, the dressing can be well made to be in the shapes of liquid, gel and emulsion, and the use is convenient;
2. through the matching of materials such as polyhexamethylene biguanide, carbomer, propylene glycol, glycerol, triethanolamine and the like, the synthesis of intramembranous liposome can be well inhibited, the apoptosis of thalli is caused, the optimal sterilization effect is achieved, and the bactericidal dressing has excellent freezing resistance, the quality of the dressing can be well improved, and the service cycle is prolonged;
in conclusion, the medical dressing has an antibacterial repair function, has good biocompatibility, cell affinity and mechanical properties, has excellent water permeation, air permeation or drainage and moisture absorption effects, has the effects of resisting bacteria and diminishing inflammation, reducing wound infection and quickly relieving wound pain, has the effects of relieving pigmentation and promoting wound healing in a wound healing period, can naturally fall off along with epidermal regeneration, reduces treatment time, wound infection probability and other characteristics, and has skin care effects of epidermal wound repair, aging skin tightening and aging resistance, water replenishing and whitening, allergy resistance and skin beautifying on human skin; can also be used for female vulva and vagina antibiosis, cleaning and anti-aging repair, can promote vagina collapse and damaged mucosa and tissue repair, recover vagina skin tissue elasticity, maintain vagina microenvironment stability, and promote vagina health.
Drawings
FIG. 1 is a flow chart of a preparation method of a medical dressing containing recombinant human collagen according to the present invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and examples, which are provided for the purpose of illustration only and are not intended to limit the scope of the invention.
Example 1
A medical dressing containing recombinant human collagen is composed of the following raw materials in percentage by weight:
0.5 to 1.5 percent of recombinant human collagen
3 to 7 percent of ceramide
2 to 6 percent of nicotinamide
Medical chitosan 0.6-1%
Ginseng extract 0.5-1.5%
0.2 to 0.6 percent of chamomile extract
0.3 to 0.7 percent of purslane extract
0.1-0.5% of aloe extract
0.1 to 0.3 percent of natural lactic acid
0.1-0.5 thousandth of polyhexamethylene biguanide
Carbomer 0.3% -0.7%
3 to 7 percent of propylene glycol
1 to 5 percent of glycerin
0.05 to 0.15 percent of triethanolamine
The remainder was purified water.
In the invention, the recombinant human collagen is a high molecular biological protein produced by reverse transcription of mRNA of human collagen into cDNA by a bioengineering technology, enzyme digestion, gene recombination and high-density fermentation, separation, renaturation and purification processes in escherichia coli; ceramide is a phospholipid with ceramide as a skeleton, and mainly comprises ceramide phosphorylcholine and ceramide phosphorylethanolamine; niacinamide is a derivative of vitamin B3; the medical chitosan has the inhibition effect on the growth of various bacteria; the ginseng extract is warm in nature, sweet, slightly bitter and slightly warm in taste; the chamomile extract is bitter, pungent and slightly cold in physical property, has the effects of clearing heat and eliminating dampness, and has the functions of resisting bacteria, diminishing inflammation and relieving pain; the purslane extract has sour and cold physical properties and tastes, and has the effects of clearing heat and removing toxicity, cooling blood and stopping bleeding and stopping dysentery; aloe extract is bitter in taste and cold in nature; purified water refers to water having a resistivity greater than 0.1x106 Ω cm at a temperature greater than 25 ℃.
In the invention, the nicotinamide is white crystalline powder, odorless or almost odorless, bitter in taste and slightly hygroscopic, the polyhexamethylene biguanide is colorless to light amber solution, the polyhexamethylene biguanide is a derivative of high molecular polymer, and as a main disinfection and sterilization component, the carbomer is white loose powder and has characteristic slight odor, the carbomer is a high molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether, the propylene glycol is colorless, slightly viscous and sweet liquid, the glycerol is colorless, odorless, sweet and clear and viscous liquid, the triethanolamine is colorless to light yellow transparent viscous liquid and slightly ammoniacal, and becomes colorless to light yellow cubic crystal system crystals at low temperature.
Example 2
A medical dressing containing recombinant human collagen is composed of the following raw materials in percentage by weight:
in the invention, 1% of recombinant human collagen is a high molecular biological protein produced by reverse transcription of mRNA of human collagen into cDNA by a biological engineering technology, a section of gene recombination after enzyme digestion and E.coli (escherichia coli) through high-density fermentation, separation, renaturation and purification processes, the molecular weight of the collagen is 1500-3000 daltons, which is more easily absorbed by human body, wherein the collagen with molecular weight of about 2000 daltons is most stable and easily absorbed by human body, and the recombinant human collagen 5 has the advantages of: high repairability: promoting the growth of fibroblasts; high safety: the gene engineering has scientific research results, no virus hidden danger and no rejection reaction; high moisture retention: the dissolved water can penetrate into the dermis; high compatibility: the gene sequence is 100 percent identical to human collagen; high sensitivity resistance: promote cell growth to form a protective barrier.
In the invention, ceramide 5% is a phospholipid taking ceramide as a skeleton, which mainly comprises ceramide phosphorylcholine and ceramide phosphorylethanolamine, the phospholipid is a main component of a cell membrane, 40-50% of sebum in a horny layer is composed of ceramide, the ceramide is a main part of an intercellular matrix and plays an important role in keeping the moisture balance of the horny layer, the ceramide exists in all eukaryotic cells and has an important regulation effect on vital activities such as cell differentiation, proliferation, apoptosis, aging and the like, and the ceramide is a main component of intercellular lipid of the horny layer of the skin, not only serves as a second messenger molecule in a sphingomyelin pathway, but also plays an important role in the formation process of the horny layer of the epidermis, and has the effects of maintaining a skin barrier, moisturizing, resisting aging, whitening, treating diseases and the like.
In the invention, 4% of nicotinamide is a derivative of vitamin B3, and is a skin anti-aging ingredient recognized in the field of beauty skin science, which is more and more important in recent years, and the most important effect in the aspect of skin anti-aging is to reduce and prevent dark skin color, yellowing and vegetable color generated in the early aging process of skin, and certainly, the nicotinamide contributes far more to the skin, and can also repair damaged stratum corneum lipid barrier and improve skin resistance, and has some effects which can be ignored by people, namely the deep water locking effect of the nicotinamide, so that the skin care product containing the nicotinamide has extremely strong water locking and moisturizing effects.
In the invention, 0.8 percent of medical chitosan has inhibition effect on the growth of various bacteria and shows the characteristics similar to antibiotics, the chitosan has inhibition effect on experimental strains such as staphylococcus epidermidis, staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, candida albicans and the like, even on candida albicans which are difficult to inhibit by common antibiotics, the original structure of the cell wall of the bacteria is damaged by the interaction of positive charges carried by the chitosan and negative charges carried by the cell membrane of the microorganisms, the leakage of cell components is caused to play an antibacterial role, and the small molecular chitosan generates similar flocculation effect by biological macromolecules which permeate into the cells and carry anions, disturbs the normal physiological function of the cells, blocks the biosynthesis of DNA, thereby inhibiting the propagation and growth of the bacteria, the chitosan can promote the regeneration of epithelial cells, promote wound healing by mediating cell proliferation, attract a large amount of polymorphonuclear cells and macrophages by mild acute inflammatory reaction to clear tissue fragments and blood, promote the migration of the fibroblasts, have chemotaxis, migration and activation effects on the stromal cells, and accelerate cell proliferation and tissue remodeling processes, the chitosan has the hemostatic effect, and simultaneously, the chitosan realizes hemostasis mainly through the agglutination effect of erythrocytes through the interaction between the chitosan and erythrocyte membranes, and the hemostatic mechanism is as follows: the chitosan with positive charge interacts with the receptor of neuraminic acid residue with negative charge on the surface of the cell to promote the aggregation of blood platelets, activate the blood coagulation system and crosslink red blood cells to form blood clots, and the chitosan has obvious film forming effect and can accelerate wound healing and prevent major hemorrhage.
In the invention, 1% of ginseng extract is warm in nature, sweet in taste, slightly bitter and slightly warm in taste, and has effects of invigorating spleen and lung channel, and can be prepared into health food for resisting fatigue, resisting aging and nourishing brain in the medical health industry; in the cosmetic hygienic product industry, the cosmetic can be prepared into hygienic products for removing spots, reducing wrinkles, activating skin cells and enhancing skin elasticity.
In the invention, 0.4% of chamomile extract is bitter in taste, pungent and slightly cold in nature, has the effects of clearing heat and eliminating dampness, has the effects of resisting bacteria and diminishing inflammation, relieving pain, and can improve allergy-relieving effects such as young beans, allergy, eczema, burn and scald in the aspect of skin care; has good effects on improving irregular menstruation, menstrual pain and the like of women.
In the invention, 0.5 percent of purslane extract is sour and cold in nature; it enters liver and large intestine meridians; has effects in clearing away heat and toxic materials, cooling blood, stopping bleeding, and relieving dysentery; preventing skin from drying and aging, increasing skin comfort, scavenging free radicals, and improving skin comfort; can be used for resisting oxidation, resisting bacteria and inhibiting common pathogenic dermatophytes.
In the invention, the aloe extract is 0.3 percent, bitter in taste and cold in nature; the aloe wine belongs to liver and large intestine channels, is mainly used for treating heat accumulation constipation, liver fire headache, conjunctival congestion and convulsion, abdominal pain due to parasitic amassment, mange, hemorrhoids and fistula, contains 75 elements, is almost completely matched with substances required by human cells, has obvious health care value, is called as 'magic plant' and 'family medicine box' by people, has the effects of promoting healing, immunological regeneration and the like on human bodies, has good nutrition, moistening and whitening effects on human skin due to polysaccharide and various vitamins contained in the aloe, has the functions of converging, softening, moisturizing, diminishing inflammation and bleaching the skin, has the effects of relieving sclerosis, keratinization and improving scars, can prevent small wrinkles, eye bags and loose skin, can keep the skin moist and delicate, can treat skin inflammation, has good curative effects on acne, freckles, acne, scald, knife wound, insect bite and the like, and is also effective on hair, can keep hair moist and smooth, and prevent alopecia.
In the invention, 0.2 percent of natural lactic acid can well increase nutrition and is beneficial to promoting cell recovery, thereby achieving the effects of moisturizing, whitening, deep purification, epidermis repair, skin-refreshing, anti-aging, skin-beautifying nutrition, anti-allergy, skin-beautifying and the like.
In the invention, polyhexamethylene biguanide 0.3 per mill is a derivative of a high molecular polymer, and is used as a main disinfection and sterilization component, guanidino in the component has high activity in polymerization reaction, so that the polymerized derivative is electropositive, and is easily adsorbed by various bacteria and viruses which are usually electronegative, thereby inhibiting the division function of the bacteria and the viruses, leading the bacteria and the viruses to lose the reproductive function, and a film formed by the polymer blocks the respiratory channel of the microorganisms, leading the microorganisms to suffocate and lose the vitality so as to achieve the sterilization effect; has the advantages of broad-spectrum sterilization, low effective concentration, high action speed, stable property, easy water dissolution, long-term bacteriostasis, no side effect, no corrosivity, no color, no odor, no toxicity, safe use and the like.
In the invention, 0.5 percent of carbomer is a high molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether, is a commonly used additive of sanitary products, is favored by manufacturers of the sanitary products due to the special efficacy, the first carbomer has the effect of protecting the skin, and because of having certain affinity with the skin, the carbomer can reduce the irritation and damage of irritative substances to the skin and mucous membranes when being added into skin care products, the second carbomer has the effect of resisting ultraviolet rays, can enhance the resistance of the skin to ultraviolet rays and reduce the damage of the ultraviolet rays to the skin, the third carbomer can also reduce the viscosity, has certain looseness, and is a slightly acidic substance with particularly strong dilutability, so a proper amount of carbomer can be added when the gel or the sanitary products are manufactured, the viscosity of the substances is reduced, and the stability of effective substances is maintained, fourthly, the carbomer has the functions of diminishing inflammation and sterilizing, is a natural medicinal component and can sterilize and diminish inflammation, and fifth, the quality of the sanitary product can be ensured through some neutralization effects, so that the carbomer plays an important role in the production of the sanitary product.
In the present invention, propylene glycol 5%, a colorless, slightly viscous and sweet liquid, can be used as a humectant in conjunction with glycerin or sorbitol in hygiene products, toothpaste and soap.
In the invention, 3% of glycerol, glycerol and glycerin have a chemical formula of C3H8O3, are colorless, odorless, sweet in taste, clear and viscous in appearance, are organic substances, can absorb moisture from air, and mainly play roles in lubrication and moisture preservation.
In the present invention, 0.1% of triethanolamine, i.e., tris (2-hydroxyethyl) amine, is an organic compound having the following properties: colorless to pale yellow transparent viscous liquid with slight ammonia smell becomes colorless to pale yellow cubic crystal at low temperature, and is used as emulsifier, humectant, moisturizer, thickener, pH balancer in sanitary products (including skin washing, eye gel, moisturizer, shampoo, etc.).
In the invention, the rest of the purified water has a resistivity of more than 0.1x106 omega cm at a temperature of more than 25 ℃, the purified water is water prepared by a distillation method, an ion exchange method, a reverse osmosis method or other suitable methods for medicine, and does not contain any additive, and the properties are as follows: is a colorless clear liquid; no odor and no taste.
In the invention, the closed sensitization test method is used for testing the medicine, and the product of the invention does not irritate the skin or cause anaphylactic reaction on the skin.
In the invention, the average healing rate of the wound surface at each sampling point of the formula product is higher than that of a contrast group in a contrast test of wound healing, and the effect of promoting wound healing is very good.
In the invention, compared with the test on the bacteriostatic action of bacteria on the wound, the bacteriostatic rate of each sampling point of the formula product of the invention on various bacteria is higher than that of a comparison group, so that the wound can be effectively protected.
Referring to fig. 1, the invention also provides a preparation method of the medical dressing containing the recombinant human collagen, which comprises the following steps:
s1, slowly adding the uniformly mixed medical chitosan, carbomer, glycerol and propylene glycol into water while stirring, heating to 80-85 ℃, and continuously stirring until the medical chitosan and the carbomer are completely dissolved to obtain a first mixed solution;
s2, cooling the first mixed solution to 40-45 ℃, adding recombinant human collagen, ceramide, nicotinamide, ginseng extract, chamomile extract, purslane extract and aloe extract into the first mixed solution, fully and uniformly stirring, and filtering with 200-mesh filter cloth to obtain a second mixed solution;
s3, adding polyhexamethylene biguanide and natural lactic acid into the second mixed solution, and fully and slowly stirring uniformly to obtain a mixture;
s4, adding the balance of purified water into the mixture, adding triethanolamine, and stirring uniformly;
and S5, vacuumizing, stirring uniformly, and removing bubbles.
In the invention, raw materials and mixing instruments are prepared according to the mass ratio, a worker slowly adds medical chitosan, carbomer, glycerol and propylene glycol which are uniformly mixed into water while stirring, the temperature is raised to 80-85 ℃ after the medical chitosan and the carbomer are completely dissolved by stirring, a first mixed solution is obtained, the first mixed solution is stirred and cooled to 40-45 ℃, then recombinant human collagen, ceramide, nicotinamide, ginseng extract, chamomile extract, purslane extract and aloe extract are added into the first mixed solution, the mixture is fully and uniformly stirred, a second mixed solution is obtained by filtering with 200-mesh filter cloth, polyhexamethylene biguanide and natural lactic acid are added into the second mixed solution, the mixture is fully and uniformly stirred slowly, the rest purified water is added into the mixture, triethanolamine is added, the mixture is uniformly stirred, vacuumizing, stirring uniformly, and removing bubbles.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A medical dressing containing recombinant human collagen is characterized by comprising the following raw materials in percentage by weight:
0.5 to 1.5 percent of recombinant human collagen
3 to 7 percent of ceramide
2 to 6 percent of nicotinamide
Medical chitosan 0.6-1%
Ginseng extract 0.5-1.5%
0.2 to 0.6 percent of chamomile extract
0.3 to 0.7 percent of purslane extract
0.1-0.5% of aloe extract
0.1 to 0.3 percent of natural lactic acid
0.1-0.5 thousandth of polyhexamethylene biguanide
Carbomer 0.3% -0.7%
3 to 7 percent of propylene glycol
1 to 5 percent of glycerin
0.05 to 0.15 percent of triethanolamine
The remainder was purified water.
2. The medical dressing containing the recombinant human collagen according to claim 1, which is characterized by comprising the following raw materials in percentage by weight:
1 percent of recombinant human collagen
Ceramide 5%
4 percent of nicotinamide
Medical chitosan 0.8%
Ginseng radix extract 1%
Chamomile extract 0.4%
0.5 percent of purslane extract
Aloe extract 0.3%
0.2 percent of natural lactic acid
0.3 per mill of polyhexamethylene biguanide
Carbomer 0.5%
Propylene glycol 5%
3 percent of glycerin
0.1 percent of triethanolamine
The remainder was purified water.
3. The medical dressing containing the recombinant human collagen according to claim 1, wherein: the recombinant human collagen is a high molecular biological protein produced by reverse transcription of mRNA of human collagen into cDNA by a biological engineering technology, enzyme digestion, gene recombination and high-density fermentation, separation, renaturation and purification processes in escherichia coli; the ceramide is a phospholipid with ceramide as a skeleton, and mainly comprises ceramide phosphorylcholine and ceramide phosphorylethanolamine; said nicotinamide is a derivative of vitamin B3; the medical chitosan has an inhibiting effect on the growth of various bacteria; the ginseng extract is warm in nature, sweet in taste, slightly bitter and slightly warm; the chamomile extract is bitter, pungent and slightly cold in physical property, has the effects of clearing heat and eliminating dampness, and has the functions of resisting bacteria, diminishing inflammation and relieving pain; the herba Portulacae extract has sour and cold physical properties and effects of clearing heat and detoxicating, cooling blood and stopping bleeding, and stopping dysentery; the aloe extract is bitter in taste and cold in nature; the purified water is water having a resistivity of greater than 0.1x106 Ω cm at a temperature of greater than 25 ℃.
4. The medical dressing containing the recombinant human collagen according to claim 1, wherein: said nicotinamide is white crystalline powder, odorless or almost odorless, bitter in taste, and slightly hygroscopic.
5. The medical dressing containing the recombinant human collagen according to claim 1, wherein: the polyhexamethylene biguanide is a colorless to light amber solution, and the polyhexamethylene biguanide is a derivative of a high molecular polymer and is used as a main disinfection and sterilization component.
6. The medical dressing containing the recombinant human collagen according to claim 1, wherein: the carbomer is white loose powder, has characteristic micro-odor and is a high molecular polymer of acrylic acid bonded allyl sucrose or pentaerythritol allyl ether.
7. The medical dressing containing the recombinant human collagen according to claim 1, wherein: the propylene glycol is colorless, slightly viscous and sweet liquid, the glycerol is colorless, odorless, sweet in taste and clear and viscous liquid in appearance, the triethanolamine is colorless to light yellow transparent viscous liquid with slight ammonia smell, and becomes colorless to light yellow cubic crystal system crystals at low temperature.
8. A preparation method of a medical dressing containing recombinant human collagen is characterized by comprising the following steps:
s1, slowly adding the uniformly mixed medical chitosan, carbomer, glycerol and propylene glycol into water while stirring, heating to 80-85 ℃, and continuously stirring until the medical chitosan and the carbomer are completely dissolved to obtain a first mixed solution;
s2, cooling the first mixed solution to 40-45 ℃, adding recombinant human collagen, ceramide, nicotinamide, ginseng extract, chamomile extract, purslane extract and aloe extract into the first mixed solution, fully and uniformly stirring, and filtering with 200-mesh filter cloth to obtain a second mixed solution;
s3, adding polyhexamethylene biguanide and natural lactic acid into the second mixed solution, and fully and slowly stirring uniformly to obtain a mixture;
s4, adding the balance of purified water into the mixture, adding triethanolamine, and stirring uniformly;
and S5, vacuumizing, stirring uniformly, and removing bubbles.
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| CN115581798A (en) * | 2022-11-01 | 2023-01-10 | 珠海市雅莎医疗器械有限公司 | Liquid wound dressing for improving dark skin color and preparation method thereof |
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Application publication date: 20210716 |