CN114377193A - Positioning noninvasive repair formula for injection - Google Patents
Positioning noninvasive repair formula for injection Download PDFInfo
- Publication number
- CN114377193A CN114377193A CN202210164807.3A CN202210164807A CN114377193A CN 114377193 A CN114377193 A CN 114377193A CN 202210164807 A CN202210164807 A CN 202210164807A CN 114377193 A CN114377193 A CN 114377193A
- Authority
- CN
- China
- Prior art keywords
- parts
- injection
- positioning
- repair
- noninvasive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 36
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 12
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 claims abstract description 12
- 229920001661 Chitosan Polymers 0.000 claims abstract description 12
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 229960001631 carbomer Drugs 0.000 claims abstract description 12
- 229960001284 citicoline Drugs 0.000 claims abstract description 12
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 12
- 235000001968 nicotinic acid Nutrition 0.000 claims abstract description 12
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 12
- 229960000502 poloxamer Drugs 0.000 claims abstract description 12
- 229920001983 poloxamer Polymers 0.000 claims abstract description 12
- 239000008213 purified water Substances 0.000 claims abstract description 12
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 12
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000002439 hemostatic effect Effects 0.000 description 2
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a positioning noninvasive repair formula for injection, which comprises the following raw materials in parts by weight: 8-12 parts of citicoline, 8-12 parts of nicotinic acid, 30-70 parts of purified water, 10-20 parts of propylene glycol, 3-5 parts of poloxamer, 1-3 parts of carbomer, 1-1.5 parts of chitosan and 0.5-1.5 parts of sodium hyaluronate. The invention has the advantages that: the injection repair device has the advantages of reasonable raw material design, convenient manufacture and use, good repair effect on positioning non-invasive repair for injection and good popularization prospect.
Description
Technical Field
The invention relates to a positioning noninvasive repair formula for injection.
Background
The existing hemostatic repair methods and means for medical wounds and wound surfaces are various, and the methods including various physical methods, chemical methods, hydrogel and the like have advantages and disadvantages, and some hemostatic effects are poor, so that the wounds and the wound surfaces are not easy to heal. How to provide a positioning noninvasive repair formula for injection becomes a research direction.
Disclosure of Invention
The invention aims to provide a positioning noninvasive repair formula for injection, which aims to solve the problems in the background technology.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a positioning noninvasive repair formula for injection comprises the following raw materials in parts by weight: 8-12 parts of citicoline, 8-12 parts of nicotinic acid, 30-70 parts of purified water, 10-20 parts of propylene glycol, 3-5 parts of poloxamer, 1-3 parts of carbomer, 1-1.5 parts of chitosan and 0.5-1.5 parts of sodium hyaluronate.
As a preferred scheme, the injection positioning noninvasive repair formula comprises the following raw materials in parts by weight: 8 parts of citicoline, 12 parts of nicotinic acid, 30 parts of purified water, 10 parts of propylene glycol, 3 parts of poloxamer, 3 parts of carbomer, 1 part of chitosan and 1.5 parts of sodium hyaluronate.
As a preferred scheme, the injection positioning noninvasive repair formula comprises the following raw materials in parts by weight: 12 parts of citicoline, 8 parts of nicotinic acid, 70 parts of purified water, 20 parts of propylene glycol, 5 parts of poloxamer, 1 part of carbomer, 1.5 parts of chitosan and 0.5 part of sodium hyaluronate.
As a preferred scheme, the injection positioning noninvasive repair formula comprises the following raw materials in parts by weight: 10 parts of citicoline, 10 parts of nicotinic acid, 50 parts of purified water, 15 parts of propylene glycol, 4 parts of poloxamer, 2 parts of carbomer, 1.3 parts of chitosan and 1 part of sodium hyaluronate.
The invention has the advantages that: the injection repair device has the advantages of reasonable raw material design, convenient manufacture and use, good repair effect on positioning non-invasive repair for injection and good popularization prospect.
Detailed Description
The invention is illustrated below by means of specific examples, without being restricted thereto.
Example 1
A positioning noninvasive repair formula for injection comprises the following raw materials in parts by weight: 8 parts of citicoline, 12 parts of nicotinic acid, 30 parts of purified water, 15 parts of glycerol, 10 parts of propylene glycol, 4 parts of simethicone, 3 parts of poloxamer, 3 parts of carbomer, 1 part of chitosan and 1.5 parts of sodium hyaluronate.
Example 2
A positioning noninvasive repair formula for injection comprises the following raw materials in parts by weight: 12 parts of citicoline, 8 parts of nicotinic acid, 70 parts of purified water, 20 parts of propylene glycol, 5 parts of poloxamer, 1 part of carbomer, 1.5 parts of chitosan and 0.5 part of sodium hyaluronate.
Example 3
A positioning noninvasive repair formula for injection comprises the following raw materials in parts by weight: 10 parts of citicoline, 10 parts of nicotinic acid, 50 parts of purified water, 15 parts of propylene glycol, 4 parts of poloxamer, 2 parts of carbomer, 1.3 parts of chitosan and 1 part of sodium hyaluronate.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (4)
1. The formula for the positioning noninvasive repair for injection is characterized by comprising the following raw materials in parts by weight: 8-12 parts of citicoline, 8-12 parts of nicotinic acid, 30-70 parts of purified water, 10-20 parts of propylene glycol, 3-5 parts of poloxamer, 1-3 parts of carbomer, 1-1.5 parts of chitosan and 0.5-1.5 parts of sodium hyaluronate.
2. The formulation for positioning and noninvasive repair for injection according to claim 1, comprising the following raw materials in parts by weight: 8 parts of citicoline, 12 parts of nicotinic acid, 30 parts of purified water, 10 parts of propylene glycol, 3 parts of poloxamer, 3 parts of carbomer, 1 part of chitosan and 1.5 parts of sodium hyaluronate.
3. The formulation for positioning and noninvasive repair for injection according to claim 1, comprising the following raw materials in parts by weight: 12 parts of citicoline, 8 parts of nicotinic acid, 70 parts of purified water, 20 parts of propylene glycol, 5 parts of poloxamer, 1 part of carbomer, 1.5 parts of chitosan and 0.5 part of sodium hyaluronate.
4. The formulation for positioning and noninvasive repair for injection according to claim 1, comprising the following raw materials in parts by weight: 10 parts of citicoline, 10 parts of nicotinic acid, 50 parts of purified water, 15 parts of propylene glycol, 4 parts of poloxamer, 2 parts of carbomer, 1.3 parts of chitosan and 1 part of sodium hyaluronate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210164807.3A CN114377193A (en) | 2022-02-23 | 2022-02-23 | Positioning noninvasive repair formula for injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210164807.3A CN114377193A (en) | 2022-02-23 | 2022-02-23 | Positioning noninvasive repair formula for injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114377193A true CN114377193A (en) | 2022-04-22 |
Family
ID=81204872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210164807.3A Pending CN114377193A (en) | 2022-02-23 | 2022-02-23 | Positioning noninvasive repair formula for injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114377193A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN107469068A (en) * | 2017-08-04 | 2017-12-15 | 南京碧迪可医药科技有限公司 | A kind of pharmaceutical composition of sulphur peptide ring element |
| CN107715168A (en) * | 2017-10-18 | 2018-02-23 | 张家港蓝智生物科技有限公司 | A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric |
| WO2021078864A1 (en) * | 2019-10-22 | 2021-04-29 | Giellepi S.P.A. | Compositions for the treatment of epithelial lesions |
| CN113117137A (en) * | 2021-04-20 | 2021-07-16 | 山东慕驰生物医药科技有限公司 | Medical dressing containing recombinant human collagen and preparation method thereof |
-
2022
- 2022-02-23 CN CN202210164807.3A patent/CN114377193A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN107469068A (en) * | 2017-08-04 | 2017-12-15 | 南京碧迪可医药科技有限公司 | A kind of pharmaceutical composition of sulphur peptide ring element |
| CN107715168A (en) * | 2017-10-18 | 2018-02-23 | 张家港蓝智生物科技有限公司 | A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric |
| WO2021078864A1 (en) * | 2019-10-22 | 2021-04-29 | Giellepi S.P.A. | Compositions for the treatment of epithelial lesions |
| CN113117137A (en) * | 2021-04-20 | 2021-07-16 | 山东慕驰生物医药科技有限公司 | Medical dressing containing recombinant human collagen and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220422 |
|
| RJ01 | Rejection of invention patent application after publication |