CN107715168A - A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric - Google Patents

A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric Download PDF

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Publication number
CN107715168A
CN107715168A CN201710968188.2A CN201710968188A CN107715168A CN 107715168 A CN107715168 A CN 107715168A CN 201710968188 A CN201710968188 A CN 201710968188A CN 107715168 A CN107715168 A CN 107715168A
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parts
chitosan
carbomer
vitric
stanching
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CN201710968188.2A
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张劲松
朱礼飞
李保芝
张宇辰
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Zhangjiagang Blue Zhi Biological Technology Co Ltd
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Zhangjiagang Blue Zhi Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric, it is related to the improvement that a kind of Medical wounded surface repairs gel, and in particular to a kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric.It is that micropore biological activity glass and chitosan are prepared for main functional component using poloxamer or carbomer as gel matrix material, and the parts by weight of its composition of raw materials are as follows：Carbomer：1~2 part, micropore biological activity glass：3~20 parts, medical glycerine：35.5 65.5 parts, propane diols：25.5 55.5 parts, chitosan：0.8~2.0 part, Sodium Hyaluronate：0.2~1.0 part.The present invention reduces bleeding, long-acting bacteriostatic, wound healing by the suction-operated of micropore biological glass and the hemostasis of bioactivity glass and chitosan, promotion healing function.It is a functional medical device product having a extensive future.

Description

A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric
Technical field
The present invention relates to the improvement that a kind of Medical wounded surface repairs gel, more particularly to a kind of hemostasis of microballoon containing bio-vitric Promoting healing uterine neck wound repair anhydrous gel.
Background technology
Micropore glass is a kind of particulate porous glass, good, the high mechanical strength of rigidity, mainly for the production of vagcor, Applied to bioengineering, genetic engineering, the refined and solidification enzyme of biology and medicines.
Micropore glass has developed into many purposes due to its distinctive composition, structure and possessed characteristic New function material.Medically, the medical seperation films such as blood purification can be used as.
Hydrogel is the gel using water as decentralized medium.One is introduced in water soluble polymer with cross-linked network Divide hydrophobic grouping and hydrophilic residue, hydrophilic residue and water molecules, hydrone is connected to netted inside, and hydrophobic residue is met Water swellable cross-linked polymer.It is a kind of macromolecule network system, property is soft, can keep certain shape, can absorb a large amount of Water.
The mode and means that medical wound at present, surface of a wound hemostasis are repaired are varied, including all kinds of physical methods, chemistry These methods such as method, hydrogel respectively have advantage and disadvantage, and some haemostatic effects are poor, aqueous in some dispensings, and aqueous gel can be led Wound, the surface of a wound is caused to be not easy to heal.
Chinese patent 201610665254.4 disclose a kind of wound healing and repair cervical mucosa gel, it by Carbomer, triclosan, hyaluronic acid, basic fibroblast growth factor, transforming growth factor β, sodium hydroxide, pure water group Into, carbomer 1%-3%, triclosan 0.1%-0.5%, hyaluronic acid 0.05%-0.1%, basic fibroblast growth because Sub- 0.000001%-0.00005%, transforming growth factor β 0.000001%-0.00005%, sodium hydroxide 0.05%- 0.1%th, pure water surplus.
The content of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide a kind of hemostasis of microballoon containing bio-vitric Promoting healing uterine neck wound repair anhydrous gel, it passes through the suction-operated of micropore biological glass and bioactivity glass and chitosan Hemostasis, promote healing function, reduce bleeding, long-acting bacteriostatic, wound healing；With haemostatic effect is good, neutralization is oozed out, is resisted The advantages that inflammation, induction epithelium regeneration, wound healing is can speed up, reduces recurrence.
To achieve the above object, the present invention is using following technical scheme：It using poloxamer or carbomer is solidifying that it, which is, Matrix material, micropore biological activity glass and chitosan are prepared for main functional component, the parts by weight of its composition of raw materials Number is as follows：Carbomer：1~2 part, micropore biological activity glass：3~20 parts, medical glycerine：35.5-65.5 parts, propane diols： 25.5-55.5 parts, chitosan：0.8~2.0 part, Sodium Hyaluronate：0.2~1.0 part.
The present invention is healed by the suction-operated of micropore biological glass and the hemostasis of bioactivity glass and chitosan, promotion Function, reduce bleeding, long-acting bacteriostatic, wound healing.It is a functional medical device product having a extensive future.It Main feature：
1st, anastalsis：By nanometer level microporous and chitosan powder, can quick adsorption blood reduce bleeding rapidly；
2nd, neutralize and ooze out, anti-inflammatory：The specific PH of bio-vitric, sepage and anti-inflammatory are effectively neutralized, preferable healing environment is created, subtracts Few scabies secondary infection；
3rd, epithelium regeneration is induced：Bioactivity glass promotes synthesis and part of the 4th type collagen fiber albumen and epidermal growth factor Secrete, actively induce the propagation of epithelial cell, break up and divide a word with a hyphen at the end of a line, so as to effectively facilitate wound healing；
4th, surface of a wound scar is reduced：Adjust tissue cell proliferation, significantly shorten the wound repair time, so as to reduce the generation of scar；
5th, not water content in being formulated, series reaction, wound healing can gradually occur after gel and interstitial fluid contacts.
After adopting the above technical scheme, the present invention has the beneficial effect that：Quick-acting haemostatic powder reduction is oozed out, the uterine neck of antibacterial anti-inflammatory is repaiied Multiple gel can speed up wound healing, reduce wound recurrence.
Embodiment
Embodiment 1
The present embodiment use technical scheme be：It is the micropore biological using poloxamer or carbomer as gel matrix material Activity glass and chitosan are prepared for main functional component, and the parts by weight of its composition of raw materials are as follows：Carbomer：1 part, it is micro- Hole bioactive glass：3 parts, medical glycerine：35.5 parts, propane diols：25.5 parts, chitosan：0.8 part, Sodium Hyaluronate：0.2 Part.
Described carbomer selects Acritamer 940.
The present invention is healed by the suction-operated of micropore biological glass and the hemostasis of bioactivity glass and chitosan, promotion Function, reduce bleeding, long-acting bacteriostatic, wound healing.It is a functional medical device product having a extensive future.It Main feature：
1st, anastalsis：By nanometer level microporous and chitosan powder, can quick adsorption blood reduce bleeding rapidly；2nd, neutralize and ooze Go out, anti-inflammatory：The specific PH of bio-vitric, sepage and anti-inflammatory are effectively neutralized, create preferable healing environment, reduce scabies secondary infection； 3rd, epithelium regeneration is induced：Bioactivity glass promotes the synthesis of the 4th type collagen fiber albumen and epidermal growth factor to be secreted with part, main The propagation of dynamic induction epithelial cell, break up and divide a word with a hyphen at the end of a line, so as to effectively facilitate wound healing；4th, surface of a wound scar is reduced：Adjust tissue Cell propagation, significantly shorten the wound repair time, so as to reduce the generation of scar；5th, not water content in being formulated, when gel and group Series reaction, wound healing can gradually occur after knitting liquid contact.
After adopting the above technical scheme, the present invention has the beneficial effect that：Quick-acting haemostatic powder reduction is oozed out, the uterine neck of antibacterial anti-inflammatory is repaiied Multiple gel can speed up wound healing, reduce wound recurrence.
Embodiment 2
The present embodiment use technical scheme be：It is the micropore biological using poloxamer or carbomer as gel matrix material Activity glass and chitosan are prepared for main functional component, and the parts by weight of its composition of raw materials are as follows：Carbomer：1.5 parts, Micropore biological activity glass：10 parts, medical glycerine：45 parts, propane diols：40 parts, chitosan：1.5 parts, Sodium Hyaluronate：0.6 Part.
Embodiment 3
The present embodiment use technical scheme be：It is the micropore biological using poloxamer or carbomer as gel matrix material Activity glass and chitosan are prepared for main functional component, and the parts by weight of its composition of raw materials are as follows：Carbomer：2 parts, it is micro- Hole bioactive glass：20 parts, medical glycerine：65.5 parts, propane diols：55.5 parts, chitosan：2.0 parts, Sodium Hyaluronate：1.0 Part.
It is described above, it is merely illustrative of the technical solution of the present invention and unrestricted, those of ordinary skill in the art are to this hair The other modifications or equivalent substitution that bright technical scheme is made, without departing from the spirit and scope of technical solution of the present invention, It all should cover among scope of the presently claimed invention.

Claims (5)

  1. A kind of 1. functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric, it is characterised in that：It is to moor Luo Shamu or carbomer are gel matrix material, micropore biological activity glass and chitosan be main functional component prepare and Into the parts by weight of its composition of raw materials are as follows：Carbomer：1~2 part, micropore biological activity glass：3~20 parts, medical glycerine： 35.5-65.5 parts, propane diols：25.5-55.5 parts, chitosan：0.8~2.0 part, Sodium Hyaluronate：0.2~1.0 part.
  2. 2. a kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric according to claim 1, It is characterized in that：It is using poloxamer or carbomer as gel matrix material, and micropore biological activity glass and chitosan are Main functional component is prepared, and the parts by weight of its composition of raw materials are as follows：Carbomer：1 part, micropore biological activity glass：3 Part, medical glycerine：35.5 parts, propane diols：25.5 parts, chitosan：0.8 part, Sodium Hyaluronate：0.2 part.
  3. 3. a kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric according to claim 1, It is characterized in that：It is using poloxamer or carbomer as gel matrix material, and micropore biological activity glass and chitosan are Main functional component is prepared, and the parts by weight of its composition of raw materials are as follows：Carbomer：1.5 parts, micropore biological activity glass： 10 parts, medical glycerine：45 parts, propane diols：40 parts, chitosan：1.5 parts, Sodium Hyaluronate：0.6 part.
  4. 4. a kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric according to claim 1, It is characterized in that：It is using poloxamer or carbomer as gel matrix material, and micropore biological activity glass and chitosan are Main functional component is prepared, and the parts by weight of its composition of raw materials are as follows：Carbomer：2 parts, micropore biological activity glass：20 Part, medical glycerine：65.5 parts, propane diols：55.5 parts, chitosan：2.0 parts, Sodium Hyaluronate：1.0 part.
  5. 5. a kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of microballoon containing bio-vitric according to claim 1, It is characterized in that：Described carbomer selects Acritamer 940.
CN201710968188.2A 2017-10-18 2017-10-18 A kind of functions of stanching and promoting healing uterine neck wound repair anhydrous gel of the microballoon containing bio-vitric Pending CN107715168A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108686252A (en) * 2018-06-11 2018-10-23 南方医科大学 It is a kind of using chitosan-poloxamer as nano silver antibiotic dressing of matrix and its preparation method and application
CN110038156A (en) * 2019-04-19 2019-07-23 南通蓝智新材料科技有限公司 Hemostasis promotees wound healing lotion and preparation method thereof
CN113546212A (en) * 2021-08-23 2021-10-26 克尔维特(福州)医疗科技有限公司 Liquid dressing with cervical post-operation hemostasis function and infection prevention function and application
CN114272205A (en) * 2021-12-30 2022-04-05 广州朗圣药业有限公司 Gel with cervical surface protection function
CN114377193A (en) * 2022-02-23 2022-04-22 张慧姊 Positioning noninvasive repair formula for injection

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101011598A (en) * 2006-12-15 2007-08-08 杨春蓉 Hemostatic, bone impairment renovation material with bioactivity
CN103830769A (en) * 2014-03-24 2014-06-04 贵州扬生医用器材有限公司 Gynecologic gel with antibacterial restoration activity and preparation method thereof
CN105169458A (en) * 2015-09-25 2015-12-23 胡方 Biological activity mineral substance material and application of biological activity mineral substance material to soft tissue anabrosis and long-time erosion wound cell regeneration and melanoma restraining
CN107007874A (en) * 2017-03-20 2017-08-04 江西虹景天药业有限公司 A kind of silicon substrate wound repair aqueous gel and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101011598A (en) * 2006-12-15 2007-08-08 杨春蓉 Hemostatic, bone impairment renovation material with bioactivity
CN103830769A (en) * 2014-03-24 2014-06-04 贵州扬生医用器材有限公司 Gynecologic gel with antibacterial restoration activity and preparation method thereof
CN105169458A (en) * 2015-09-25 2015-12-23 胡方 Biological activity mineral substance material and application of biological activity mineral substance material to soft tissue anabrosis and long-time erosion wound cell regeneration and melanoma restraining
CN107007874A (en) * 2017-03-20 2017-08-04 江西虹景天药业有限公司 A kind of silicon substrate wound repair aqueous gel and preparation method thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108686252A (en) * 2018-06-11 2018-10-23 南方医科大学 It is a kind of using chitosan-poloxamer as nano silver antibiotic dressing of matrix and its preparation method and application
CN108686252B (en) * 2018-06-11 2021-05-18 深圳英凡妮生物科技有限公司 Nano-silver antibacterial dressing with chitosan-poloxamer as matrix and preparation method and application thereof
CN110038156A (en) * 2019-04-19 2019-07-23 南通蓝智新材料科技有限公司 Hemostasis promotees wound healing lotion and preparation method thereof
CN113546212A (en) * 2021-08-23 2021-10-26 克尔维特(福州)医疗科技有限公司 Liquid dressing with cervical post-operation hemostasis function and infection prevention function and application
CN114272205A (en) * 2021-12-30 2022-04-05 广州朗圣药业有限公司 Gel with cervical surface protection function
CN114272205B (en) * 2021-12-30 2023-09-08 广州朗圣药业有限公司 Gel with cervical surface protection effect
CN114377193A (en) * 2022-02-23 2022-04-22 张慧姊 Positioning noninvasive repair formula for injection

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Application publication date: 20180223