CN112169015A - Sodium alginate hydrogel for promoting wound healing and reducing scars and preparation method thereof - Google Patents
Sodium alginate hydrogel for promoting wound healing and reducing scars and preparation method thereof Download PDFInfo
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention discloses a sodium alginate hydrogel for promoting wound healing and reducing scars, which comprises the following components in percentage by weight: 10-20% of carrageenan, 5-20% of sodium alginate, 3-5% of emulsifier, 1-10% of humectant, 0.5-8% of penetration enhancer, 0.5-2% of antioxidant, 1-15% of active ingredient and the balance of purified water. Also discloses a preparation method thereof: weighing the raw material components according to the weight ratio of the components, mixing and stirring the carrageenan, the sodium alginate, the emulsifier and the active component, then adding the penetration enhancer, the humectant and the antioxidant, mixing, adding water, stirring uniformly, and stirring at 300rpm of 100-. The hydrogel agent has high gel strength and good stability, promotes wound healing, has an antibacterial effect and a remarkable scar hyperplasia resisting effect.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a sodium alginate hydrogel for promoting wound healing and reducing scars and a preparation method thereof.
Background
Skin wounds often generate scars, the scars can be proliferated to affect the appearance, and large-area scars and proliferation can even cause reduced touch, loss of flexibility and loss of motion range; skin wounds are also often susceptible to infection. The traditional gauze dressing has great influence on the wound surface during replacement, and is easy to cause tearing bleeding and scar formation on the wound surface. Different moist dressings are therefore available on the market, mainly: alginate dressings and foam dressings, hydrocolloid dressings and hydrogel dressings are suitable for different wound conditions, and different kinds of dressings have advantages and disadvantages respectively. The hydrogel dressing is suitable for nursing wounds with little or no exudate, but the hydrogel dressings on the market at present generally have the problems of poor strength, easy breakage, easy impregnation of surrounding tissues, difficult moisture regulation, weak adhesion with the skin surface and the like; the hydrogel dressing on the market at present has unsatisfactory hemostatic, antipruritic and antibacterial effects, unsatisfactory scar removing effect and unsatisfactory skin healing effect after use.
Sodium alginate is a byproduct after iodine and mannitol are extracted from brown algae such as kelp or gulfweed, the molecule of the sodium alginate is formed by connecting beta-D-mannuronic acid (beta-D-mannuronic acid, M) and alpha-L-guluronic acid (alpha-L-guluronic acid, G) according to a (1 → 4) bond, and the sodium alginate is a natural polysaccharide and has stability, solubility, viscosity and safety required by pharmaceutical preparation auxiliary materials.
Sodium alginate was introduced into the united states pharmacopeia as early as 1938. The sodium alginate contains a large amount of-COO-, can show polyanion behavior in aqueous solution, has certain adhesiveness, and can be used as a drug carrier for treating mucosal tissues. Under the acidic condition, the-COO-is converted into-COOH, the ionization degree is reduced, the hydrophilicity of the sodium alginate is reduced, molecular chains are shrunk, when the pH value is increased, the-COOH groups are continuously dissociated, the hydrophilicity of the sodium alginate is increased, and the molecular chains are stretched. Therefore, sodium alginate has significant pH sensitivity. Sodium alginate can form gel rapidly under extremely mild conditions, and Ca is available2+、Sr2+Na on G unit in the presence of an isocation+And carrying out ion exchange reaction with divalent cations, and stacking the G units to form a cross-linked network structure, thereby forming the hydrogel. The gel forming condition of the sodium alginate is mild, which can avoid the inactivation of active substances such as sensitive medicines, proteins, cells, enzymes and the like.
The sodium alginate gel has the advantages of high water content, multiple functions, biocompatibility, porosity, smoothness and the like, can keep the moist environment of the wound surface, is beneficial to wound healing, and reduces scar formation. In addition, the sodium alginate hydrogel can promote platelet and erythrocyte aggregation and promote wound hemostasis. Sodium alginate gels have the potential to trigger release of active substances in a more controlled manner to the external environment, such as pH, so sodium alginate-based wound dressings are more effective when used on wounds with less exudate. Due to these excellent properties, sodium alginate has been widely used in the food industry and in the medical field.
However, the use of pure sodium alginate gel is limited because sodium alginate dissolves rapidly under neutral and alkaline conditions. And the sodium alginate has weak antibacterial property and limited performance of promoting the healing of the wound surface.
Disclosure of Invention
Aiming at the problems, the invention provides the sodium alginate hydrogel which has high gel strength, good stability, wound healing promotion, antibacterial effect and obvious scar hyperplasia resistance and the preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a sodium alginate hydrogel for promoting wound healing and reducing scars comprises the following components in percentage by weight: 10-20% of carrageenan, 5-20% of sodium alginate, 3-5% of emulsifier, 1-10% of humectant, 0.5-8% of penetration enhancer, 0.5-2% of antioxidant, 1-15% of active ingredient and the balance of purified water.
Preferably, the carrageenan is one or more of kappa carrageenan, iota carrageenan and lambda carrageenan.
Preferably, the emulsifier is span and tween.
Further preferably, the emulsifier is span 80.
Preferably, the active ingredient is one or more of soybean isoflavone, hydrocortisone acetate, hydrocortisone sodium succinate, vitamin E succinate, and aloe extract.
Preferably, the humectant is one or more of glycerol, 1, 3-butylene glycol, polyethylene glycol, propylene glycol, sorbitol or sodium lactate.
Preferably, the penetration enhancer is one or more of isopropyl myristate, laurocapram, dimethyl sulfoxide, PEG-200 or tween 20.
Preferably, the antioxidant is one or more of ascorbic acid, sodium sulfite, pyrosulfite, sodium bisulfite, ascorbyl palmitate, butylated hydroxytoluene, propyl gallate or tocopherol.
The preparation method of any one of the sodium alginate hydrogel agent comprises the following steps: weighing the raw material components according to the weight ratio of the components, mixing and stirring the carrageenan, the sodium alginate, the emulsifier and the active component, then adding the penetration enhancer, the humectant and the antioxidant, mixing, adding water, stirring uniformly, and stirring at 300rpm of 100-.
The invention has the beneficial effects that:
1) the structure of the pure sodium alginate gel can be damaged under neutral or alkaline conditions, so that the gel is degraded, the carrageenan increases the repulsion force of sulfate groups with negative electrons during neutral alkaline, the gel strength is enhanced, the gel stability is improved, and the gel still keeps better stability under alkaline conditions, so that the application range of the sodium alginate gel is expanded.
2) After the skin wound surface is formed, the liquid permeated from the wound contains a large amount of potassium ions, sodium ions and calcium ions, and carrageenan and sodium alginate in the gel are crosslinked under the initiation of the ions and stacked to form a three-dimensional crosslinked network structure, so that hydrogel is formed; in addition, the carrageenan degradation product has a certain antibacterial effect, the use of antibacterial auxiliary materials is reduced, and the gel provided by the invention also has an antibacterial effect.
3) After the sodium alginate and the carrageenan are combined, the scar-resistant effect is obvious: the hydrogel dressing has the advantages of no adhesion, wound surface moisture maintenance and capability of absorbing exudates, and the advantages enable the hydrogel dressing to become an important research direction for clinical wound surface treatment; the carrageenan can promote the expression quantity of interferon on an organism and inhibit the generation of collagen synthetic nuclear fibroblasts, has the function of scar contracture resistance, can reduce the volume of scars, and has obvious scar hyperplasia resistance effect through the experimental verification of the invention.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to be limiting.
The experimental procedures in the following examples are conventional unless otherwise specified.
The main reagent sources are as follows:
barker: barker silica gel ointment, common name silica gel, manufacturer: the American advanced biotechnology limited company is a popular dressing for wounds in the market at present, can be used for treating healed wounds and scars after sealing the surface of the skin, and can also prevent the formation of various scars, such as hyperplastic scars and keloids caused by general operations, injuries and burns.
Aloe extract: the manufacturing company is Xinxiangbo Kai Biotechnology Inc., CAS number 8001-97-6.
The following reagents used in the experiments were all commercially available and were all commercially available:
kappa carrageenan, iota carrageenan, lambda carrageenan, sodium alginate, span 80, soybean isoflavone, hydrocortisone acetate, vitamin E succinate, hydrocortisone sodium succinate, hydrocortisone, 1, 3-butanediol, sorbitol, polyethylene glycol, propylene glycol, PEG-200 (polyethylene glycol 200), isopropyl myristate, ascorbyl palmitate, dimethyl sulfoxide, Tween 20, laurocapram, tocopherol, ascorbic acid and sodium sulfite.
The remaining reagents, if not indicated, were conventional in the art and were also commercially available.
Example 1
The sodium alginate hydrogel is prepared from the following components in percentage by weight: 18% of kappa-carrageenan, 12% of sodium alginate and the balance of purified water.
The hydrogel is prepared by the following method: weighing the raw material components according to the weight ratio of the components, uniformly stirring carrageenan, sodium alginate and purified water, and stirring at 100rpm for 60min to obtain the sodium alginate hydrogel.
Example 2
The sodium alginate hydrogel is prepared from the following components in percentage by weight: 8% of kappa carrageenan, 2% of lambda carrageenan, 5% of sodium alginate, 3% of span 80, 3% of soybean isoflavone (active ingredient), 10% of 1, 3-butanediol (humectant), 2.0% of PEG-200 (penetration enhancer), 1.0% of ascorbyl palmitate (antioxidant), and the balance of purified water.
The hydrogel is prepared by the following method: weighing the raw material components according to the weight ratio of the components, mixing and stirring the carrageenan, the sodium alginate, the span 80 and the active ingredients, then adding the penetration enhancer, the humectant and the antioxidant, mixing, adding water, stirring uniformly, and stirring for 45min at 300rpm to obtain the sodium alginate hydrogel.
Example 3
The sodium alginate hydrogel is prepared from the following components in percentage by weight: 10% of kappa carrageenan, 8% of iota carrageenan, 2% of lambda carrageenan, 20% of sodium alginate, 5% of span 80, 2% of active ingredients (hydrocortisone acetate 1%, vitamin E succinate 1%), 1% of sorbitol (humectant), 8% of isopropyl myristate (penetration enhancer), 1% of tocopherol (antioxidant) and the balance of purified water.
The hydrogel is prepared by the following method: weighing the raw material components according to the weight ratio of the components, mixing and stirring the carrageenan, the sodium alginate, the span 80 and the active ingredients, then adding the penetration enhancer, the humectant and the antioxidant, mixing, adding water, stirring uniformly, and stirring at 100rpm for 60min to obtain the sodium alginate hydrogel.
Example 4
The sodium alginate hydrogel is prepared from the following components in percentage by weight: 10% kappa carrageenan, 5% lambda carrageenan, 10% sodium alginate, 4% span 80, 15% aloe extract (active component), 5.0% polyethylene glycol (humectant), 3.0% laurocapram (penetration enhancer), 2.0% ascorbic acid (antioxidant), and the balance of purified water.
The hydrogel is prepared by the following method: weighing the raw material components according to the weight ratio of the components, mixing and stirring the carrageenan, the sodium alginate, the span 80 and the active ingredients, then adding the penetration enhancer, the humectant and the preservative, mixing, adding water, stirring uniformly, and stirring at 300rpm for 60min to obtain the sodium alginate hydrogel.
Example 5
The sodium alginate hydrogel is prepared from the following components in percentage by weight: 10% kappa carrageenan, 10% iota carrageenan, 15% sodium alginate, 4.5% span 80, 3% hydrocortisone sodium succinate (active ingredient), 10% propylene glycol (humectant), 0.5% dimethyl sulfoxide (penetration enhancer), 0.5% tocopherol (antioxidant), and the balance of purified water.
The hydrogel is prepared by the following method: weighing the raw material components according to the weight ratio of the components, mixing and stirring carrageenan, sodium alginate, span 80 and active ingredients, then adding the penetration enhancer, the humectant and the preservative, mixing, adding water, stirring uniformly, and stirring at 200rpm for 50min to obtain the sodium alginate hydrogel.
Example 6
The sodium alginate hydrogel is prepared from the following components in percentage by weight: 8% of kappa carrageenan, 8% of iota carrageenan, 2% of lambda carrageenan, 9% of sodium alginate, 3.5% of span 80, 1% of hydrocortisone (active ingredient), 5.0% of 1, 3-butanediol (humectant), 3.0% of tween 20 (permeation enhancer), 2.0% of sodium sulfite (antioxidant) and the balance of purified water.
The hydrogel is prepared by the following method: weighing the raw material components according to the weight ratio of the components, mixing and stirring carrageenan, sodium alginate, span 80 and active ingredients, then adding the penetration enhancer, the humectant and the preservative, mixing, adding water, stirring uniformly, and stirring at 100rpm for 60min to obtain the sodium alginate hydrogel.
Comparative example 1: the sodium alginate hydrogel was prepared as in example 1 except that no carrageenan was included.
Example 7 texture Properties
The hydrogel agents of examples 1-6 and comparative example 1 were examined for gel strength and tackiness using a CT-3 texture analyzer. The test was set to the push down mode, with a cylindrical P/0.5 probe selected, with a drop rate of 1mm/s and a trigger force of 5 g. When the probe contacts the surface of the sample, the descending speed is changed to 2mm/s, the pressure is reduced to 10mm, then the probe is lifted back, and the ascending speed is 10 mm/s. The stress-time curve is recorded and the pattern is processed to obtain the maximum value of the gel strength as a positive peak and the area of the tackiness as a negative peak.
The results of the gel strength and tackiness tests of examples 1 to 6 are shown in Table 1, and the hydrogel formulations prepared in examples 1 to 6 had good appearance, soft texture, and good gel strength and tackiness. The comparison between the comparative example 1 and the example 1 shows that the carrageenan and the sodium alginate are crosslinked under the initiation of the ions and stacked to form a complex three-dimensional crosslinked network structure, so that the hydrogel is formed, and the gel strength is enhanced.
TABLE 1 sample gel Strength and tackiness test
Example 8 gel stability
After 5g of the samples of examples 1 to 6 and comparative example 1 were mixed with potassium chloride to form gel, 1mL of a PBS solution (pH 7.5) was added to the surface of each gel, the gel was shaken in a shaker for 30min, and the gel was observed for appearance and the gel strength was measured, and the gel strength was measured three times on average for each sample.
TABLE 2 sample gel Strength and tackiness test
As shown in Table 2, the gel of examples 1-6 has relatively stable structure and no change in gel strength and appearance under the condition of slightly alkaline, but the gel of comparative example 1 made of pure sodium alginate has a structure damaged under the condition of neutral or slightly alkaline, which results in gel degradation. When the carrageenan and the sodium alginate exist simultaneously, the carrageenan increases the repulsion force of sulfate groups with negative electrons under neutral and alkaline conditions, enhances the gel strength, is beneficial to improving the gel stability, and can expand the application range of the sodium alginate gel.
EXAMPLE 9 gel time and inhibition of hypertrophic scarring of Rabbit ears
Selecting 12 New Zealand white rabbits, adaptively feeding the rabbits for a week at 25 ℃ under natural illumination, weighing, sterilizing with alcohol conventionally, performing intravenous injection of 3% sodium pentobarbital solution at the ear margin with the dose of 30mg/Kg to reach an anesthetic state, removing hair from the ear abdomens of the rabbits, and sequentially punching 6 circular wound cavities with the diameter of about 7mm on the ear abdomenal surface of each rabbit ear by using a biopsy puncher until the hair reaches cartilage; the blood vessels on the rabbit ears are avoided as much as possible by punching, and if the blood vessels are injured and bleed, the blood can be stopped by regular pressing with clean cotton. Then removing skin and removing perichondrium with forceps, and exposing wound surface to obtain rabbit ear wound model.
Wherein, No. 1-3 rabbit left ear is used as the experimental group (A1) of the example 2, and the hydrogel agent of the example 2 is sprayed on the scar; the right ear served as the negative control group (a0) in example 2, without any drug. No. 4-6 rabbit left ear as experimental group (B1) of example 3, spray the hydrogel agent of example 3 on the scar; the right ear served as the negative control group (B0) in example 3, without any drug. Rabbit No. 7-9, left ear as experimental group (C1) of example 4, spray the hydrogel of example 4 on the scar; the right ear served as the negative control group (C0) in example 4, without any drug. Rabbits 10-12 served as positive control group 1(D) with a Barker spray on the left ear (D1) and no drug on the right ear (D0). The gel time was calculated and averaged, and the results are shown in Table 3, which indicates that the samples of examples 2-4 completed gel transformation within 5min, and formed gel on the wound surface.
TABLE 3 gel time
Wound in rabbit ears from all groups had healed substantially 18 days after molding. The hairs on the rabbit ears are shaved again, the hydrogel is sprayed on all scars of the left ears of the rabbits, the numbers of experimental samples smeared by the experimental rabbits with different numbers are the same as the numbers of the experimental samples, the experimental samples are sprayed for 1 time in the morning and at night each day, the spraying amount is just enough to completely cover the scars, and the administration is continued for 18 days; the rabbit wounds were shaved every 3 days and the scar was wiped with a moist cotton swab before each spray to remove the wound healing hydrogel previously used. After the continuous administration for 18 days, scar hyperplasia index is measured and hyperplasia inhibition rate is calculated.
Scar proliferation index (E) is determined by analyzing HE staining Image with Image _ Propluss) Is the dermal height (H) of the scars) Divided by the dermal height (H) at normal skinn) I.e. Es＝Hs÷HnThe scar hyperplasia index can quantify the hyperplasia degree of pathological scars, and higher scar hyperplasia index represents more obvious scars.
The proliferation inhibition rate (alpha) is equal to the scar proliferation index (A) of the control group0) Subtracting scar proliferation index (A) of experimental group1) The scar proliferation index of the control group is divided by the scar proliferation index of the control group, namely alpha ═ A0-A1)÷A0。
As shown in Table 4, the scar growth index of the experimental group using the hydrogel of the present invention and the positive control group using Barker was significantly lower than that of the negative control group, indicating that examples 2-4 all had a certain scar growth resistance effect, wherein the scar growth resistance effect of example 2 was the best, and the growth inhibition rate was lower than that of the other groups, and was almost the same as that of Barker.
TABLE 4 scar hyperplasia index and hyperplasia inhibition
Finally, the above embodiments are only intended to illustrate the technical solutions of the present invention and not to limit the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions, and all of them should be covered by the claims of the present invention.
Claims (9)
1. A sodium alginate hydrogel for promoting wound healing and reducing scars is characterized in that: comprises the following components in percentage by weight: 10-20% of carrageenan, 5-20% of sodium alginate, 3-5% of emulsifier, 1-10% of humectant, 0.5-8% of penetration enhancer, 0.5-2% of antioxidant, 1-15% of active ingredient and the balance of purified water.
2. The sodium alginate hydrogel agent of claim 1, wherein said carrageenan is one or more of kappa carrageenan, iota carrageenan and lambda carrageenan.
3. The sodium alginate hydrogel agent as claimed in claim 1, wherein the emulsifier is span and tween.
4. The sodium alginate hydrogel agent as claimed in claim 3, wherein the emulsifier is span 80.
5. The sodium alginate hydrogel agent as claimed in claim 1, wherein the active ingredient is one or more of soybean isoflavone, hydrocortisone acetate, hydrocortisone sodium succinate, vitamin E succinate, and aloe extract.
6. The sodium alginate hydrogel agent as claimed in claim 1, wherein the humectant is one or more of glycerol, 1, 3-butylene glycol, polyethylene glycol, propylene glycol, sorbitol or sodium lactate.
7. The sodium alginate hydrogel agent of claim 1, wherein the penetration enhancer is one or more of isopropyl myristate, laurocapram, dimethyl sulfoxide, PEG-200 or Tween 20.
8. The sodium alginate hydrogel agent as claimed in claim 1, wherein the antioxidant is one or more of ascorbic acid, sodium sulfite, pyrosulfite, sodium bisulfite, ascorbyl palmitate, butylated hydroxytoluene, propyl gallate and tocopherol.
9. The preparation method of the sodium alginate hydrogel agent as claimed in any one of claims 1 to 8, which is characterized in that the method comprises the following steps: weighing the raw material components according to the weight ratio of the components, mixing and stirring the carrageenan, the sodium alginate, the emulsifier and the active component, then adding the penetration enhancer, the humectant and the antioxidant, mixing, adding water, stirring uniformly, and stirring at 300rpm of 100-.
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| CN (1) | CN112169015A (en) |
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| US5874479A (en) * | 1991-03-01 | 1999-02-23 | Warner-Lambert Company | Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same |
| CN109876179A (en) * | 2018-12-24 | 2019-06-14 | 深圳市琉璃光生物科技有限公司 | A kind of aerogel dressing and preparation method thereof |
| CN110200988A (en) * | 2019-06-17 | 2019-09-06 | 瑞希(重庆)生物科技有限公司 | A kind of scar repair agent and preparation method thereof |
| CN110368498A (en) * | 2019-08-26 | 2019-10-25 | 瑞希(重庆)生物科技有限公司 | A kind of preparation and preparation method thereof promoting wound healing |
| CN110664660A (en) * | 2019-10-18 | 2020-01-10 | 瑞希(重庆)生物科技有限公司 | Scar-resistant composition and preparation method thereof |
| CN111481497A (en) * | 2019-01-28 | 2020-08-04 | 北京万生人和科技有限公司 | Hydrogel |
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- 2020-09-30 CN CN202011057741.5A patent/CN112169015A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874479A (en) * | 1991-03-01 | 1999-02-23 | Warner-Lambert Company | Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same |
| CN109876179A (en) * | 2018-12-24 | 2019-06-14 | 深圳市琉璃光生物科技有限公司 | A kind of aerogel dressing and preparation method thereof |
| CN111481497A (en) * | 2019-01-28 | 2020-08-04 | 北京万生人和科技有限公司 | Hydrogel |
| CN110200988A (en) * | 2019-06-17 | 2019-09-06 | 瑞希(重庆)生物科技有限公司 | A kind of scar repair agent and preparation method thereof |
| CN110368498A (en) * | 2019-08-26 | 2019-10-25 | 瑞希(重庆)生物科技有限公司 | A kind of preparation and preparation method thereof promoting wound healing |
| CN110664660A (en) * | 2019-10-18 | 2020-01-10 | 瑞希(重庆)生物科技有限公司 | Scar-resistant composition and preparation method thereof |
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