CN1228054C - Artificial skin powder prepn containing sodium hyaluronate and its prepn - Google Patents

Artificial skin powder prepn containing sodium hyaluronate and its prepn Download PDF

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Publication number
CN1228054C
CN1228054C CN 00111241 CN00111241A CN1228054C CN 1228054 C CN1228054 C CN 1228054C CN 00111241 CN00111241 CN 00111241 CN 00111241 A CN00111241 A CN 00111241A CN 1228054 C CN1228054 C CN 1228054C
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China
Prior art keywords
powder agent
hyaluronate sodium
preparation
powder
present
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Expired - Fee Related
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CN 00111241
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CN1335135A (en
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凌沛学
王凤山
员象敏
郭学平
贺艳丽
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Individual
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Abstract

The present invention relates to a powder preparation mainly used for treating burn and scald, and a preparation method thereof, which belongs to the field of medicine. The main constituent is sodium hyaluronate which is also named as sodium hyaluronate and matched with other auxiliary materials and pharmacological active substances, such as chitin, chitosan, heparin, low molecular heparin, chondroitin sulfate, dermatan sulfate, epidermal growth factors, bactericides, etc., to prepare compound preparations to be used. The powder preparation of the present invention has the prescription that 100 g of preparation contains 1 to 100 g of sodium hyaluronate and 0 to 99 g of other auxiliary material and pharmacological active substance. The powder preparation of the present invention has obvious effect on burn and scalds, can accelerate wound surface healing, has the effects of resisting infection, and promoting granulation growth and skin regeneration, has good ventilation properties and has the advantages of stable quality, simple preparation technique, convenient use, etc.

Description

Contain artificial skin powder agent of hyaluronate sodium and preparation method thereof
The invention belongs to field of pharmaceutical technology, is a kind of artificial skin powder agent that is used for the treatment of burn and scald.Along with developing rapidly of medicinal career, wound medications such as burn and scald clinically also increase rapidly.Such as membrane such as ointments such as burn cream, antiphlogistine and chitosan artificial skin serous coats.All there are some shortcomings in these preparations without degree in the effect of performance treatment burn and scald, poor as breathability, easily cause tissue edema, complex manufacturing, use inconvenience etc.Purpose of the present invention just provides a kind of hyaluronate sodium artificial skin powder agent and preparation method thereof, and overcomes the deficiency of existing preparation.
The main component hyaluronate sodium of this powder agent is to be a kind of polymeric acidic mucopolysaccharide that disaccharidase recurring unit is formed with (1 → 4)-O-β-D-glucuronic acid-(1 → 3)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-β-D-glucose, extensively be in animal and human's body connective tissue, be network structure, have very strong water retention, can absorb moisture above 500 times of own wts.This characteristic makes hyaluronate sodium can regulate diffusion and the transhipment in skin of protein, water, electrolyte, promotes cell transfer, and wound healing is played a significant role.
Bentley finds that in the sixties in 20th century after tissue damaged, obvious rising appearred in local hyaluronic acid sodium content at once.Up to the present, confirmed that the pharmacological action of hyaluronate sodium in wound healing comprises: 1) hyaluronate sodium combines with fibrin, and the complex of formation is brought into play conformation function in wound healing process; 2) hyaluronate sodium has different structures with substrate and the independent grumeleuse that forms of fibrin that fibrin constitutes, and is obviously loose, is beneficial to cell to intramatrical infiltration and transfer; 3) hyaluronate sodium can promote granulocytic activate the phagocytic capacity, regulates the inflammation reflection; 4) the low relative molecular weight hyaluronate sodium of localized degradation generation promotes angiogenesis.
Prove that through zoopery hyaluronate sodium artificial skin powder agent prescription is reasonable, craft science.Said preparation can be evenly distributed on the burn and scald skin surface and form the loose sealing coat of one deck; good permeability absorbs wound fluid, can protect effectively, wound closure; the incrustation area is less, has to suppress the function that scar tissue generated and quickened the empyrosis wound surface healing.Experimental results show that hyaluronate sodium artificial skin powder agent is a kind of new formulation of effective treatment burn and scald, broad clinical application prospect is arranged.
The basic composition of powder agent of the present invention is: hyaluronate sodium, or hyaluronate sodium and chitosan, or hyaluronate sodium, chitin and chitosan.Be used for the treatment of burn and scald and injure accelerating wound healing, reduce scar tissue and generate.Also can on the basis of basic composition, add pharmacological active substance, as required as heparin, Low molecular heparin, chondroitin sulfate, dermatan sulfate, epidermal growth factor, antibacterial such as chlorhexidine acetate etc.
The prescription and the amount ranges of powder agent of the present invention are: in 100 gram powder agents, wherein hyaluronate sodium 1~100 restrains, in the time of need adding adjuvant and pharmacological active substance, and its amount ranges 0~99 gram.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, contain 10-20 gram hyaluronate sodium.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 100 grams.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, chitosan 90 grams.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 20 grams, chitosan 80 grams.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, heparin sodium 30000IU, all the other are chitosans.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, chondroitin sulfate 3 grams, all the other are chitosans.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, heparin sodium 30000IU, chlorhexidine acetate 0.05 gram, all the other are chitosans.
The manufacture method one of powder agent of the present invention: earlier each composition is crossed 100 mesh sieves, press the accurate weighing of formula proportion again by the prescription of powder agent of the present invention, after the mixing, coating-dividing sealing, promptly at last with oxirane or microwave sterilizating.
The manufacture method two of powder agent of the present invention: by the prescription of powder agent of the present invention each composition is crossed 100 mesh sieves earlier, respectively with oxirane or microwave sterilizating, press the accurate weighing of formula proportion again, after the mixing, coating-dividing sealing promptly.
Use the method for the artificial skin powder agent of hyaluronate sodium preparation treatment skin burn, wherein said powder agent contains as the hyaluronate sodium of active component and adjuvant chitosan, comprises 10-20 gram hyaluronate sodium in every 100g powder agent.
Embodiments of the invention:
1. powder agent of the present invention in 100 grams, is got hyaluronate sodium 100 grams, prepares according to the method for the invention.
2. the invention powder agent in 100 grams, is got hyaluronate sodium 10 grams, and chitosan 90 grams prepare according to the method for the invention.
3. powder agent of the present invention in 100 grams, is got hyaluronate sodium 20 grams, and chitosan 80 grams prepare according to the method for the invention.
4. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, heparin sodium 30000IU, and all the other are chitosans, prepare according to the method for the invention.
5. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, chondroitin sulfate 3 grams, and all the other are chitosans, prepare according to the method for the invention.
6. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, heparin sodium 30000IU, and chlorhexidine acetate 0.05 gram, all the other are chitosans, prepare according to the method for the invention.

Claims (6)

1, the artificial skin powder agent that is used for the treatment of skin burn wherein contains hyaluronate sodium and adjuvant chitosan as active component, comprises 10-20 gram hyaluronate sodium in every 100g powder agent.
2, the powder agent of claim 1 wherein also comprises the pharmacological active substance that is selected from heparin, Low molecular heparin, chondroitin sulfate and chlorhexidine acetate.
3, each powder agent of claim 1-2, wherein the granularity of each composition is 100 orders.
4, the preparation method of the powder agent described in arbitrary one of the aforementioned claim 1-3 is characterized in that: after described each composition is mixed in proportion with the pressed powder form, sterilize with oxirane or microwave again.
5, the preparation method of the powder agent described in arbitrary one of the aforementioned claim 1-3 wherein is characterised in that: each composition of pressed powder form respectively with oxirane or microwave sterilizating, is mixed in proportion again.
6, use the method for the artificial skin powder agent of hyaluronate sodium preparation treatment skin burn, wherein said powder agent contains as the hyaluronate sodium of active component and adjuvant chitosan, comprises 10-20 gram hyaluronate sodium in every 100g powder agent.
CN 00111241 2000-07-25 2000-07-25 Artificial skin powder prepn containing sodium hyaluronate and its prepn Expired - Fee Related CN1228054C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 00111241 CN1228054C (en) 2000-07-25 2000-07-25 Artificial skin powder prepn containing sodium hyaluronate and its prepn

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 00111241 CN1228054C (en) 2000-07-25 2000-07-25 Artificial skin powder prepn containing sodium hyaluronate and its prepn

Publications (2)

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CN1335135A CN1335135A (en) 2002-02-13
CN1228054C true CN1228054C (en) 2005-11-23

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003041723A1 (en) * 2001-11-12 2003-05-22 Reinmueller Johannes Pharmaceutical applications of hyaluronic acid preparations
CN101028280B (en) * 2006-03-01 2010-12-29 上海其胜生物制剂有限公司 Lavage liquor preparation for operation and its production
CN103006687A (en) * 2013-01-12 2013-04-03 何黎 Functional preparation for laser postoperative skin regeneration and preparation method
CN106727246A (en) * 2017-02-08 2017-05-31 上海元茵生物科技有限公司 Calf serum cell nutrient solution

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