CN1335135A - Artificial skin powder prepn containing sodium hyaluronate and its prepn - Google Patents
Artificial skin powder prepn containing sodium hyaluronate and its prepn Download PDFInfo
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- CN1335135A CN1335135A CN 00111241 CN00111241A CN1335135A CN 1335135 A CN1335135 A CN 1335135A CN 00111241 CN00111241 CN 00111241 CN 00111241 A CN00111241 A CN 00111241A CN 1335135 A CN1335135 A CN 1335135A
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- powder agent
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- hyaluronate sodium
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Abstract
The present invention belongs to the field of medicines and the powder for treating burns and scalds has sodium hyaluronate as main component and other supplementary material and pharmacological active matters, such as chitin, chitosan, heparin, chondroitin sulfate, dermatan sulfate, etc. The powder preparation of the present invention contains sodium hyaluronate in 1-100 wt% and other supplementary material and pharmacological active matters in 0-99 wt%. The powder preparation of the present invention has obvious treating effect on burns and scalds owing to its functions of resisting infection, promoting granulation and promoting wound healing.
Description
The invention belongs to field of pharmaceutical technology, is a kind of artificial skin powder agent that is used for the treatment of burn and scald.Along with developing rapidly of medicinal career, wound medications such as burn and scald clinically also increase rapidly.Such as membrane such as ointments such as burn cream, antiphlogistine and chitosan artificial skin serous coats.These preparations all exist some shortcomings in various degree in the effect of performance treatment burn and scald, poor as breathability, easily cause tissue edema, complex manufacturing, use inconvenience etc.Purpose of the present invention just provides a kind of hyaluronate sodium artificial skin powder agent and preparation method thereof, and overcomes the deficiency of existing preparation.
The main component hyaluronate sodium of this powder agent is to be a kind of polymeric acidic mucopolysaccharide that disaccharidase recurring unit is formed with (1 → 4)-O-β-D-glucuronic acid-(1 → 3)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-β-D-glucose, extensively be present in animal and human's body connective tissue, be network structure, have very strong water retention, can absorb moisture above 500 times of own wts.This characteristic makes hyaluronate sodium can regulate diffusion and the transhipment in skin of protein, water, electrolyte, promotes cell transfer, and wound healing is played a significant role.
Bentley finds that in the sixties in 20th century after tissue damaged, obvious rising appearred in local hyaluronic acid sodium content at once.Up to the present, confirmed that the pharmacological action of hyaluronate sodium in wound healing comprises: 1) hyaluronate sodium combines with fibrin, and the complex of formation is brought into play conformation function in wound healing process; 2) hyaluronate sodium has different structures with substrate and the independent grumeleuse that forms of fibrin that fibrin constitutes, and is obviously loose, is beneficial to cell to intramatrical infiltration and transfer; 3) hyaluronate sodium can promote granulocytic activate the phagocytic capacity, regulates inflammatory reaction; 4) the low relative molecular weight hyaluronate sodium of localized degradation generation promotes angiogenesis.
Confirm that through zoopery hyaluronate sodium artificial skin powder agent prescription is reasonable, craft science.Said preparation can be evenly distributed on the burn and scald skin surface and form the loose sealing coat of one deck; good permeability absorbs wound fluid, can protect effectively, wound closure; the incrustation area is less, has to suppress the function that scar tissue generated and quickened the empyrosis wound surface healing.Experiment confirm hyaluronate sodium artificial skin powder agent is a kind of new formulation of effective treatment burn and scald, and broad clinical application prospect is arranged.
The basic composition of powder agent of the present invention is: hyaluronate sodium, or hyaluronate sodium and chitosan, or hyaluronate sodium, chitin and chitosan.Be used for the treatment of burn and scald and injure accelerating wound healing, reduce scar tissue and generate.Also can on the basis of basic composition, add pharmacological active substance, as required as heparin, Low molecular heparin, chondroitin sulfate, dermatan sulfate, epidermal growth factor, antibacterial such as chlorhexidine acetate etc.
The prescription and the amount ranges of powder agent of the present invention are: in 100 gram powder agents, wherein hyaluronate sodium 1～100 restrains, in the time of need adding adjuvant and pharmacological active substance, and its amount ranges 0～99 gram.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 100 grams.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, chitosan 90 grams.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 20 grams, chitosan 80 grams.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, heparin sodium 30000IU, all the other are chitosans.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, chondroitin sulfate 3 grams, all the other are chitosans.
The prescription and the consumption of powder agent of the present invention are: in 100 gram powder agents, and hyaluronate sodium 10 grams, heparin sodium 30000IU, chlorhexidine acetate 0.05 gram, all the other are chitosans.
The manufacture method one of powder agent of the present invention: earlier each composition is crossed 100 mesh sieves, press the accurate weighing of formula proportion again by the prescription of powder agent of the present invention, after the mixing, coating-dividing sealing, promptly at last with oxirane or microwave sterilizating.
The manufacture method two of powder agent of the present invention: by the prescription of powder agent of the present invention each composition is crossed 100 mesh sieves earlier, respectively with oxirane or microwave sterilizating, press the accurate weighing of formula proportion again, after the mixing, coating-dividing sealing promptly.
Embodiments of the invention:
1. powder agent of the present invention in 100 grams, is got hyaluronate sodium 100 grams, prepares according to the method for the invention.
2. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, and chitosan 90 grams prepare according to the method for the invention.
3. powder agent of the present invention in 100 grams, is got hyaluronate sodium 20 grams, and chitosan 80 grams prepare according to the method for the invention.
4. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, heparin sodium 30000IU, and all the other are chitosans, prepare according to the method for the invention.
5. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, chondroitin sulfate 3 grams, and all the other are chitosans, prepare according to the method for the invention.
6. powder agent of the present invention in 100 grams, is got hyaluronate sodium 10 grams, heparin sodium 30000IU, and chlorhexidine acetate 0.05 gram, all the other are chitosans, prepare according to the method for the invention.
Claims (8)
1. one kind is the powder agent of main component with the hyaluronate sodium, is used for the treatment of burn and scald.Also contain other adjuvants and pharmacological active substance in its prescription, can directly spray during use, make into even one deck at the burn and scald skin wound.
2. according to claim 1 described powder agent, it is characterized in that containing hyaluronate sodium in the prescription, both extraction had obtained this hyaluronate sodium in animal body, and also bacterial fermentation makes molecular weight 100,000～5,000,000 dalton.
3. according to claim 1 described powder agent, its feature also is to add other adjuvant and pharmacological active substance as required in the prescription.Described adjuvant such as chitin, chitosan etc.Described other pharmacological active substancies such as heparin, Low molecular heparin, chondroitin sulfate, dermatan sulfate, epidermal growth factor and antibacterial such as chlorhexidine acetate etc.
4. according to claim 1 described powder agent, its feature is that also the adjuvant of hyaluronate sodium and adding and pharmacological component all are mixed in proportion with the pressed powder form.
5. the prescription of this serial powder agent and amount ranges is characterized in that the hyaluronic acid sodium content is 1%～100%, and when adding other pharmacological active substancies, its content is 0%～99%.
6. the granularity of each composition is 30 orders～500 orders in this serial powder agent prescription.Granularity in this serial powder agent prescription behind each components in certain proportion mixing is 30 orders～500 orders.
7. the manufacture method of this serial powder agent, it is characterized in that: behind each components in certain proportion mixing, coating-dividing sealing is sterilized with oxirane or microwave again.
8. the manufacture method of this serial powder agent, its feature also is: each composition is respectively with oxirane or microwave sterilizating, more in proportion behind the mixing, coating-dividing sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00111241 CN1228054C (en) | 2000-07-25 | 2000-07-25 | Artificial skin powder prepn containing sodium hyaluronate and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00111241 CN1228054C (en) | 2000-07-25 | 2000-07-25 | Artificial skin powder prepn containing sodium hyaluronate and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1335135A true CN1335135A (en) | 2002-02-13 |
| CN1228054C CN1228054C (en) | 2005-11-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00111241 Expired - Fee Related CN1228054C (en) | 2000-07-25 | 2000-07-25 | Artificial skin powder prepn containing sodium hyaluronate and its prepn |
Country Status (1)
| Country | Link |
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| CN (1) | CN1228054C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003041723A1 (en) * | 2001-11-12 | 2003-05-22 | Reinmueller Johannes | Pharmaceutical applications of hyaluronic acid preparations |
| CN101028280B (en) * | 2006-03-01 | 2010-12-29 | 上海其胜生物制剂有限公司 | Lavage liquor preparation for operation and its production |
| CN103006687A (en) * | 2013-01-12 | 2013-04-03 | 何黎 | Functional preparation for laser postoperative skin regeneration and preparation method |
| CN106727246A (en) * | 2017-02-08 | 2017-05-31 | 上海元茵生物科技有限公司 | Calf serum cell nutrient solution |
-
2000
- 2000-07-25 CN CN 00111241 patent/CN1228054C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003041723A1 (en) * | 2001-11-12 | 2003-05-22 | Reinmueller Johannes | Pharmaceutical applications of hyaluronic acid preparations |
| CN101028280B (en) * | 2006-03-01 | 2010-12-29 | 上海其胜生物制剂有限公司 | Lavage liquor preparation for operation and its production |
| CN103006687A (en) * | 2013-01-12 | 2013-04-03 | 何黎 | Functional preparation for laser postoperative skin regeneration and preparation method |
| CN106727246A (en) * | 2017-02-08 | 2017-05-31 | 上海元茵生物科技有限公司 | Calf serum cell nutrient solution |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1228054C (en) | 2005-11-23 |
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