CN100379465C - Inflammation-eliminating, pain-stopping, bacteria-resisting, pain-relieving soluble hemostatic gauze and its processing method - Google Patents
Inflammation-eliminating, pain-stopping, bacteria-resisting, pain-relieving soluble hemostatic gauze and its processing method Download PDFInfo
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- CN100379465C CN100379465C CNB2005101353618A CN200510135361A CN100379465C CN 100379465 C CN100379465 C CN 100379465C CN B2005101353618 A CNB2005101353618 A CN B2005101353618A CN 200510135361 A CN200510135361 A CN 200510135361A CN 100379465 C CN100379465 C CN 100379465C
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Abstract
The present invention provides soluble hemostatic gauze with the functions of eliminating inflammation, alleviating pain, resisting bacteria and alleviating pain, which relates to the field of medical care sanitary accessories. The soluble hemostatic gauze is prepared from the following substances by the weight percentage: 0.1 to 0.3% of disodium hydrogen phosphate, 1 to 1.8% of sodium alginate, 0.5 to 2% of carbomer, 1 to 10% of antibacterial medicine, 1 to 2% of polyethyleneglycol, 1 to 4% of tween-80, 0.1 to 1% of dimethyl silicon oil, 0.2 to 0.8% of sodium carboxymethylcellulose, 0.05% of benzocaine and ethanol solution as the rest. The soluble hemostatic gauze has the advantages of immediate hemostasis, broad-spectrum bacteria resistance and wound healing promoting, and also has the unique functions of alleviating pain and preventing surgical adhesion, wherein the functions have important significances for alleviating the pain of patients and enhancing the life quality of the patients.
Description
Technical field
A kind of antiinflammatory, pain relieving, antimicrobial soluble stanching gauze relate to the medical and hygiene article field.
Background technology
Present hospital gauze generally be by comprehensive fiber through spin, knit, defat, bleaching, dry, disinfect after, use for medical department, such gauze becomes the waste pollution environment after using, simultaneously after the wound incrustation, gauze can bond with wound, cause the secondary wound easily for taking off gauze when changing dressings, bring misery, be unfavorable for the timely healing of wound to the patient.Based on above-mentioned problem, people have invented soluble stanching gauze.Soluble stanching gauze is generally the product after the opposite fiber carries out defat and mystery processing, promptly pass through C, M, the NA content that the general method for making of C is made is at the SCMC of 6-8% (sodium carboxymethyl cellulose), as the Chinese patent patent No. is 91110511 and 98101676, soluble stanching gauze is clogged after the dipping antimicrobial treatment, cover various wounds, solubilized conclusion of the business shape thing behind the liquid that the chance wound oozes out, produce a large amount of anion, play the activation thrombin, promote the generation of thrombin, platelet is condensed rapidly, stifled match blood capillary, thus play hemostasis, protect wound, protect from infection, promote the effect of wound healing.But the function of this soluble stanching gauze antibiotic and sterilizing is relatively poor, can not solve the problem of tissue adhesion.
A kind of antiinflammatory, antibiotic external used synthesized medicine, Solubility Hemostatic Gauze and Processing Method have been introduced among the Chinese patent ZL02135172.4, this synthetic drug is the chemical compound that quinolinones and aminoacid reaction back forms, and soluble anti-inflammation, antibiotic, hemostatic gauze comprise the chemical compound of soluble fiber and quinolinones and aminoacid reaction back formation; Soluble anti-inflammation, processing method antibiotic, hemostatic gauze comprise the following order step: (1) aminoacid and quinolinones are adjusted concentration to 5～30% (weight) in aqueous solution or ethanol water, react 0.5～30 hour; (2) reactant in the step (1) was mixed in the alcoholic solution of 80～95% (weight) 0.5～30 hour by 1: 2～10 (weight ratios) with soluble fiber; (3) soluble fiber is taken out drying in solution.Wound site can directly be clogged, be covered to this gauze, and discharge monomer quinolinones and amino acid nutrient composition at wound, causes the secondary wound at the Shi Buhui that changes dressings, and wound healing is fast.But it is very stable and balanced that medicine and combining of soluble stanching gauze are not, medicine be not molecular structure with the best attached on the soluble stanching gauze, make the effect of disinfection not bring into play fully.
In addition, a kind of view is arranged in the prior art, think that the external application of analgesic has disadvantageous effect for the healing of wound, so prior art is generally with oral or injection analgesic.Wherein have a kind of viewpoint to think that analgesic benumbed peripheral nerve, human body can not in time be made a response to wound information like this, influences the reparation of wound; Also have a kind of viewpoint to think, the generation of the pair cell of analgesic own is influential, thereby influences the healing of wound.
Summary of the invention
An object of the present invention is for the function that solves soluble stanching gauze antibiotic and sterilizing in the above-mentioned prior art relatively poor, medicine is not that molecular structure with the best is attached on the soluble stanching gauze, make the effect of disinfection not bring into play fully, there is not analgesic activity, can not solve the problem of tissue adhesion, a kind of antiinflammatory, pain relieving, antibiotic analgesic soluble stanching gauze are provided.
Another object of the present invention provides the preparation method of a kind of antiinflammatory, pain relieving, antibiotic analgesic soluble stanching gauze.
For achieving the above object, a technical scheme of the present invention provides a kind of antiinflammatory, pain relieving, antibiotic analgesic soluble stanching gauze, constitute the sodium hydrogen phosphate of 0.1-0.3%, the sodium alginate of 1-1.8%, the carbomer of 0.5-2% by the material of following weight percentage ratio, the antibacterials of 1-10%, the Polyethylene Glycol of 1-2%, 1-4% tween 80,0.1-1% dimethicone, 0.2-0.8% sodium carboxymethyl cellulose, all the other are concentration greater than 80% alcoholic solution for 0.05% benzocaine.
Described antibacterials are the complex of povidone iodine and chlorhexidine, and wherein, the part by weight of povidone iodine and chlorhexidine is 4: 1, reaction condition is for being under the condition of 3-6.9 at pH, and adding weight percentage is the zinc oxide of 0.2-0.8%, boiling reflux 1-8 hour.
The optimization formula of a kind of antiinflammatory of the present invention, pain relieving, antibiotic analgesic soluble stanching gauze: the material by following weight percentage ratio constitutes: the carbomer of 0.2% sodium hydrogen phosphate, the sodium alginate of 1.2-1.6%, 1-1.5%, the antibacterials of 5-8%, the Polyethylene Glycol of 1.2-1.8%, 2-3% tween 80,0.4-0.6% dimethicone, 0.4-0.6% sodium carboxymethyl cellulose, 0.05% benzocaine, all the other are the alcoholic solution of 85-95% for concentration.
The aminoacid that can also comprise 0-0.05% among the present invention.Described aminoacid is aminoacid of the prior art, as tryptophan, methionine, threonine, leucine, valine, phenylalanine etc.; Optimum ratio 0.01-0.02%.
For achieving the above object, another technical scheme of the present invention provides the preparation method of a kind of antiinflammatory, pain relieving, antibiotic analgesic soluble stanching gauze.
Configuration concentration is the alcoholic solution more than 80%, add sodium hydrogen phosphate, sodium alginate, carbomer, add antibacterials then, elevated temperature is to 45-85 ℃, stir, add soluble stanching gauze, stir or the condition of ultrasonic vibrations under carry out dynamic chemical and take out gauze after in conjunction with 0.5-60 hour, continuous Polyethylene Glycol, tween 80, dimethicone, the sodium carboxymethyl cellulose that adds in original liquid, the semi-finished product gauze is put into medicinal liquid, proceed dynamic chemical in conjunction with 1-30 hour under 45-85 ℃, take out, the drying with steam oven dry gets product.
Say the preparation method of a kind of antiinflammatory of the present invention, pain relieving, antibiotic analgesic soluble stanching gauze further.
Configuration concentration is the alcoholic solution of 85-95%, add sodium hydrogen phosphate, sodium alginate, carbomer, add antibacterials then, elevated temperature is to 50-70 ℃, stir, add soluble stanching gauze, stir or the condition of ultrasonic vibrations under carry out dynamic chemical and take out gauze after in conjunction with 4-12 hour, continuous Polyethylene Glycol, tween 80, dimethicone, the sodium carboxymethyl cellulose of adding in original liquid, the semi-finished product gauze is put into medicinal liquid, proceed dynamic chemical in conjunction with 4-12 hour under 45-85 ℃, take out, drying with steam gets product.
Further say the preparation method of a kind of antiinflammatory of the present invention, pain relieving, antibiotic analgesic soluble stanching gauze.
Configuration concentration is the alcoholic solution of 90-95%, add aminoacid, elevated temperature is to 50-60 ℃, the glycerol that adds 0.1-0.5%, add antibacterials, the adjusting pH value is 8-12, boiling reflux 2-3 hour, add sodium hydrogen phosphate then, sodium alginate, carbomer, elevated temperature stirs to 50-60 ℃, add soluble stanching gauze, after dynamic chemical under the condition of stirring or ultrasonic vibrations was in conjunction with 4-8 hour, take out gauze, the continuous Polyethylene Glycol that adds in original liquid, tween 80, dimethicone, sodium carboxymethyl cellulose is put into medicinal liquid with the semi-finished product gauze, the adjusting pH value is 3-6.8, proceed dynamic chemical in conjunction with 4-8 hour under 50-60 ℃, take out, oven dry gets product.
Beneficial effect:
Product of the present invention is compared with prior art products:
1. this product has antiseized, sterilization, antiinflammatory, stops blooding and certain debridement effect is arranged wound.
2. this product combines many combinations complex of antibacterials thing and analgesic drug product for being carrier with the fiber carboxymethyl ester, and all the other products are one pack system in the prior art.
3. this product is except that possessing hemostasis at once, broad-spectrum antiseptic, promotion wound healing, also possesses unique pain relieving, prevents the function of tissue adhesion.This function is for reducing the patient suffering, and it is significant undoubtedly to improve patient's life quality.
4. because soluble stanching gauze is loose porous material, can the chemical bond said medicine, said medicine has suitable molecular structure in certain ph value and certain solution environmental in addition, can with soluble stanching gauze by electrostatic attraction and combination, so can realize the quantitative chemical combination.Reach excellent sterilization, sterilization, analgesic effect.
Disinfectant for external use such as povidone iodine and chlorhexidine with can bring into play synergism after soluble stanching gauze combines, make product of the present invention wider than the antimicrobial spectrum of prior art, antibacterial activity is stronger, can reduce the side effect of local analgesia agent simultaneously.This point infects prevention and treatment and alleviates the patient suffering simultaneously and have important function undoubtedly.Povidone iodine and chlorhexidine make product dissolving of the present invention back be easier to make antibacterials to separate from gauze under the attack of hydrone with the combination of gauze in addition, thereby can better bring into play antibacterial action.
6. added aminoacid is one of necessary aminoacid of human body, provides essential nutritional labeling for promoting tissue repair and wound healing.Therefore add this product behind the aminoacid and have the effect of significant promotion wound healing.
The specific embodiment
Enumerate embodiment below, the present invention is further specified, but the present invention is not only limited to these embodiment.
Embodiment 1
Configuration concentration is 85% alcoholic solution, the sodium hydrogen phosphate that adds 0.2kg, 1.5kg sodium alginate, the carbomer of 1kg, the antibacterials that add 6kg then, elevated temperature is to 45-85 ℃, stir, add soluble stanching gauze, stir or the condition of ultrasonic vibrations under carry out dynamic chemical and take out gauze after in conjunction with 1-30 hour, the continuous Polyethylene Glycol that adds 1.5kg in original liquid, the 3kg tween 80,0.5kg dimethicone, 0.5kg sodium carboxymethyl cellulose, the semi-finished product gauze is put into medicinal liquid, proceed dynamic chemical in conjunction with 5-25 hour under 45-85 ℃, take out, the drying with steam oven dry gets product.
Embodiment 2-6
Prepare a kind of antiinflammatory, pain relieving, antibiotic analgesic soluble stanching gauze, raw materials used and proportioning such as following table according to embodiment 1 described method
| Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Sodium hydrogen phosphate | 0.1 | 0.15 | 0.3 | 0.25 | 0.2 |
| Sodium alginate | 1.5 | 1.2 | 1 | 1.8 | 1.6 |
| Carbomer | 1.3 | 0.5 | 2 | 1.5 | 1 |
| Antibacterials | 10 | 5 | 8 | 1 | 6 |
| Polyethylene Glycol | 2 | 1.2 | 1.8 | 1.5 | 1 |
| Tween 80 | 2 | 1 | 4 | 3 | 2.5 |
| Dimethicone | 0.4 | 0.6 | 0.1 | 1 | 0.5 |
| Sodium carboxymethyl cellulose | 0.8 | 0.4 | 0.6 | 0.2 | 0.5 |
| Benzocaine | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 |
| Aminoacid | 0 | Tryptophan 0.01 | Methionine 0.02 | Threonine 0.05 | Leucine 0.01 |
| Alcoholic solution | Concentration 85% ethanol | Concentration 90% ethanol | Concentration 95% ethanol | Concentration 80% ethanol | Concentration 85% ethanol |
| Solution 81.85 | Solution 89.89 | Solution 82.13 | Solution 89.85 | Solution 86.64 |
The product of the embodiment of the invention 1 is carried out the zoopery contrast with the product that obtains the processing method production of introducing among the Chinese patent ZL02135172.4 of domestic patent, 80 of choosing test rats, random packet, test group and matched group are 40 examples, skin to back 2*2cm after test group and the control rats unhairing carries out aseptic process, two groups of rats all alternately inoculate the positive bacteria in the same culture dish at random, test group is carried out antibacterial therapy with this patent product then, and matched group uses the product of the processing method production of introducing among the Chinese patent ZL02135172.4 of same area to treat.Test the healing state of observing wound surface after three days.To the evaluation of healing state, according to surgery evaluation methodology commonly used: it is good that first class healing, wound do not have red and swollen healing; The second class healing, wound circumference has redness or poroma, but does not have suppuration; The third class healing, wound is suppurative infection.Add up the case load of two treated animal first, second, the third three grades of healings respectively.Heal as the good evaluation criterion of Disinfection Effect with first class.Experimental result is as follows:
| Group | The first class healing | The second class healing | The third class healing |
| Test group | 40(100％) | 0 | 0 |
| Matched group | 30(75) | 0 | 0 |
Above-mentioned data are carried out statistical procedures with X 2 test.Compare P＜0.05 between group, this patent product is compared antibacterial effect with the matched group product the significance progress.
The product of the embodiment of the invention 1 is carried out the zoopery contrast with having obtained the product that the processing method introduced among the Chinese patent ZL02135172.4 of domestic patent produces, find that this product is in analgesia with prevent from all to compare according to set product aspect the tissue adhesion marked improvement (P＜0.05) is arranged.Experimental result is as follows:
| Group | Analgesic effect is good | Analgesic effect is poor |
| Test group | 40(100％) | 0 |
| Matched group | 0(100％) | 40 |
| Group | Tissue adhesion example number | No tissue adhesion example number |
| Test group | 0 | 39(97.5％) |
| Matched group | 15 | 25(62.5％) |
Claims (4)
1. an antiinflammatory, pain relieving, antimicrobial soluble stanching gauze, comprise the sodium hydrogen phosphate of the material 0.1-0.3% of following weight percentage ratio, the sodium alginate of 1-1.8%, the carbomer of 0.5-2%, the antibacterials of 1-10%, the Polyethylene Glycol of 1-2%, 1-4% tween 80,0.1-1% dimethicone, 0.2-0.8% sodium carboxymethyl cellulose, 0.05% benzocaine, all the other are alcoholic solution more than 80% for concentration.
2. antiinflammatory according to claim 1, pain relieving, antimicrobial soluble stanching gauze, it is characterized in that, described antibacterials are the complex of povidone iodine and chlorhexidine, part by weight by povidone iodine and chlorhexidine is 4: 1, reaction condition is for being under the condition of 3-6.9 at pH, and adding weight percentage is the zinc oxide of 0.2-0.8%, and boiling reflux 1-8 hour resulting.
3. antiinflammatory according to claim 1, pain relieving, antimicrobial soluble stanching gauze, it is characterized in that, material by following weight percentage ratio constitutes: the carbomer of 0.2% sodium hydrogen phosphate, the sodium alginate of 1.2-1.6%, 1-1.5%, the antibacterials of 5-8%, the Polyethylene Glycol of 1.2-1.8%, 2-3% tween 80,0.4-0.6% dimethicone, 0.4-0.6% sodium carboxymethyl cellulose, 0.05% benzocaine, all the other are the alcoholic solution of 85-95% for concentration.
4. antiinflammatory according to claim 1, pain relieving, antimicrobial soluble stanching gauze is characterized in that, also comprise the aminoacid of 0-0.05%.
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| CNB2005101353618A CN100379465C (en) | 2005-12-31 | 2005-12-31 | Inflammation-eliminating, pain-stopping, bacteria-resisting, pain-relieving soluble hemostatic gauze and its processing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450221A (en) * | 2007-11-30 | 2009-06-10 | 张博 | Soluble absorbable hemostasia products based on modified viscose fiber and preparation method thereof |
| CN101284144B (en) * | 2008-05-30 | 2011-06-08 | 上海爱灵卫生材料有限公司 | Soluble hemostatic cotton |
| CN103623461A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Soluble hemostatic gauze with functions of antisepsis and anti-inflammation |
| CN103611185B (en) * | 2013-12-03 | 2016-02-24 | 安徽缘远博爱生物技术有限公司 | A kind of Radix Sophorae Flavescentis sterilization soluble stanching gauze |
| CN103623459B (en) * | 2013-12-03 | 2016-02-24 | 安徽缘远博爱生物技术有限公司 | A kind of soluble stanching gauze of germicidal anti-inflammatory myogenic |
| CN103623458B (en) * | 2013-12-03 | 2016-02-24 | 安徽缘远博爱生物技术有限公司 | A kind of pseudo-ginseng blood-circulation-invigovating promoting healing water-soluble hemostatic gauze |
| CN104383586B (en) * | 2014-12-01 | 2016-05-11 | 哈尔滨工业大学 | A kind of nm of gold/lysine/oxidized regenerated cellulose compound hemostatic material and preparation method thereof |
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| CN1045354A (en) * | 1989-03-10 | 1990-09-19 | 铁汉 | Non-adhesive gauze for reducing inflammation and accelerating recovery |
| WO2003075812A1 (en) * | 2002-03-06 | 2003-09-18 | Salvona L.L.C. | Controlled delivery patch of active ingredient |
| CN1466974A (en) * | 2002-07-11 | 2004-01-14 | 博 张 | Anti-inflammation antibiotic external used synthesized medicine, soluble hemostatic gauze and method for making the same |
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Patent Citations (3)
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|---|---|---|---|---|
| CN1045354A (en) * | 1989-03-10 | 1990-09-19 | 铁汉 | Non-adhesive gauze for reducing inflammation and accelerating recovery |
| WO2003075812A1 (en) * | 2002-03-06 | 2003-09-18 | Salvona L.L.C. | Controlled delivery patch of active ingredient |
| CN1466974A (en) * | 2002-07-11 | 2004-01-14 | 博 张 | Anti-inflammation antibiotic external used synthesized medicine, soluble hemostatic gauze and method for making the same |
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Assignee: Qingdao Etsong Bioengineering Co., Ltd. Assignor: Zhang Bo Contract fulfillment period: 2008.11.6 to 2025.12.30 Contract record no.: 2008370000209 Denomination of invention: Inflammation-eliminating, pain-stopping, bacteria-resisting, pain-relieving soluble hemostatic gauze and its processing method Granted publication date: 20080409 License type: Exclusive license Record date: 20081219 |
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