CN101284144B - Soluble hemostatic cotton - Google Patents
Soluble hemostatic cotton Download PDFInfo
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- CN101284144B CN101284144B CN200810038322XA CN200810038322A CN101284144B CN 101284144 B CN101284144 B CN 101284144B CN 200810038322X A CN200810038322X A CN 200810038322XA CN 200810038322 A CN200810038322 A CN 200810038322A CN 101284144 B CN101284144 B CN 101284144B
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Abstract
The invention relates to a soluble hemostatic cotton, which is prepared from absorbent cotton as raw material, and sodium hydroxide aqueous solution and disodium hydrogen phosphate as reactant liquor by performing activating reaction; pouring into a reaction kettle; adding acid reactant liquor for performing oxidation reaction; neutralizing with hydrochloric acid until the pH value of the reactant liquor is 6.5-8; cleaning the reacted absorbent cotton in an industrial washing machine with 75% ethanol aqueous solution, repeatedly washing for three times until the sodium content is smaller than 10 wt%; and spin drying, drying, carding and shredding. The hemostatic cotton is a hemostatic material for effectively controlling open wound and celomic hemorrhage, contains no chemical additive, thrombin or collagen, and has low hypersensitivity. The hemostatic cotton expands three to four times in volume when coming into contact with blood, and is converted into biogel which can be dissolved into glucose and sodium chloride, without impeding wound healing as other hemostatic materials.
Description
Technical field
The present invention relates to a kind of medical material, particularly a kind of soluble hemostatic cotton.
Background technology
Chinese patent literature CN1270240A has introduced a kind of stanch fibre and manufacture method thereof, and it is that 130,000 pharmaceutical grade gelatin is put into the 700g distilled water with the 237.5g molecular weight, adds swelling 150 minutes at room temperature; The 12.5g polyvinylpyrrolidone is put into the 300g distilled water, 40 ℃ of dissolvings down; Dissolved feed liquid is respectively put into gelatin after the swelling, be warming up to 75 ℃, stirred miscible 90 minutes, then compound is filtered; Mixed liquor after the filtration pumps in the gravity tank; After 4 hours, when being controlled at 60 ℃, opens feed temperature valve 60 ℃ of following standing and defoaming; Mixed liquor enters centrifugal box-spinning machine by dosing pump, and pump is 150g/ minute for amount or speed, and the centrifugal pan linear velocity is 6000 meters/minute, and feed liquid is spun into short fiber rapidly; Make stanch fibre at last.
But, above-mentioned stanch fibre through swelling, stir miscible, filtration, deaeration, spinning, after weave and just make stanch fibre.Its operation is various, long processing time, and cost of material requires high, and equipment investment is big, and area of mill site is big.The scope of application is confined to the hemostasis of plane wound surface.
Another piece Chinese patent literature CN1286329A has introduced a kind of water-soluble staltic cellulose fibre and manufacture method thereof, at first with pretreated textile fiber as raw material, its method for making comprises with sodium hydrate aqueous solution and activating, carry out etherificate with a haloalkyl acid reaction liquid, with making its pH with fiber in the hydrochloric acid is 6.5-7.5, with ethanol water be the geology salinity smaller or equal to 3%, carry out solid-liquid separation at last, oven dry, combing, shredding.
According to embodiment 1, the embodiment 3 of above-mentioned patent documentation introduction, the explained hereafter of embodiment 5, embodiment 6, find that water-soluble staltic cellulose fibre caking, jaundice, the quality produced are harder.Through combing, shredding, form the harder short fiber of quality, with textile fiber very big difference is arranged.Through soluble test, get the 1g water-soluble staltic cellulose fibre and put into the 50g clean water, surpass 24 hours and still have insoluble matter to exist.
Summary of the invention
The object of the present invention is to provide a kind of soluble hemostatic cotton, mainly solve the defective of above-mentioned existing product and method, it is a kind ofly can effectively control open wound and body cavity (oral cavity, earhole, nostril, throat, vagina and anus etc.) hemorrhage hemostatic material, this material does not contain chemical addition agent, thrombin or collagen protein, and anaphylaxis is low; By when directly contacting with blood, its volume energy expansion three-to-four-fold, and change into a kind of biogum that can be dissolved as glucose and sodium chloride.Because its high-purity and the characteristic of degradation product, it can not hinder the reparation of wound as other hemostatic material.
For achieving the above object, technical scheme of the present invention is:
A kind of soluble hemostatic cotton is characterized in that it comprises to be prepared as follows step:
Step 1: with degreasing cotton is raw material, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 50-60% and percetage by weight 5-5.5% as reactant liquor, bath raio is respectively to be put into reaction vessel together in 1: 58 and 1: 6.3 and carries out priming reaction;
Step 2: raw material in the step 1 and reactant liquor are poured in the reactor together, poured into acid reaction liquid again and carry out oxidation reaction;
Step 3: after the oxidation, the reactant liquor pH that is neutralized in the step 2 with hydrochloric acid is 6.5～8;
Step 4: after the neutralization, the ethanol water with 75% is the degreasing cotton behind the cleaning reaction in industry washer, cleans repeatedly 3 times, until containing the sodium amount less than 10% percentage by weight; Dry then, oven dry, combing, shredding.
The chloroacetic acid that contains 60-70% in the described step 2 in this acid reaction liquid, 10% salicylic acid, 5% glycine, all the other are water; Raw material and reactant liquor are according to bath raio 2.5: 7.7-1.7: 7 carry out oxidation reaction; Reaction temperature is 60-90 ℃, and the response time is 4-6 hour.
Be raw material with degreasing cotton in the described step 1, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 50% and percetage by weight 5% as reactant liquor, bath raio is respectively to be put into closed stainless steel cask in 1: 58 and 1: 6.3 together and leaves standstill and carry out priming reaction.
Be raw material with degreasing cotton in the described step 1, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 60% and percetage by weight 5.5% as reactant liquor, bath raio is respectively to be put into reactor in 1: 58 and 1: 6.3 together and carried out priming reaction in 2 hours in 40 ℃ of processing.
By said structure, the present invention mainly has following advantage:
1, soluble hemostatic cotton is the collagen sample natural materials of being produced through chemical modification by the Plant fiber.Profile has kept the form of pure natural Cotton Gossypii, the porosity height, and roughness is big, and plasticity is strong.The wound surface that not only can be used for plane, the wound surface of cavity type also can use, and can make different shape, as spherical, column, lamellar or the like, because soluble hemostatic cotton as the softness of pure natural Cotton Gossypii, when contacting with wound surface, can form the shape that is fit to wound surface at once.It is a kind of hemorrhage hemostatic material that can effectively control open wound and body cavity (oral cavity, earhole, nostril, throat, vagina and anus etc.).This material does not contain chemical addition agent, thrombin or collagen protein, and anaphylaxis is low.By when directly contacting with blood, its volume energy expansion three-to-four-fold, and change into a kind of biogum that can be dissolved as glucose and sodium chloride.Because its high-purity and the characteristic of degradation product, it can not hinder the reparation of wound as other hemostatic material.
2, soluble hemostatic cotton exists the stage all to bring into play effect its three: absorb, expand, dissolving.It is to exist with solid form at the beginning, and it can reduce hemorrhage by its coarse relatively surface, and this also makes some thrombin have adequate time to gather the wound.When it begins to expand, it combines with platelet and sludged blood, makes it more promptly to form thrombosis, thus minimizing or stop hemorrhage.At last, when it was in dissolved state, it can continue to play a role in hemostasis and wound rehabilitation.These concrete mechanism will be set forth in the paragraph below.The successful part part of this product just is the timeliness of the uniqueness of its this three phases that passes through.
3, compare with other materials, the advantage of soluble hemostatic cotton is that it can play the effect of three aspects: 1) chemical aspect; 2) biochemistry aspect; 3) physics aspect.In its participated in hemostasis, if the some aspects in three aspects had lost efficacy, other two or one can also be continued to play a role, and especially expanded and the activation process of liquid phase.This soluble material in addition when chemistry that does not use other or serum class side-product also still than market on other insoluble substance more effective.
4, another characteristic of this material is its biocidal property.This specific character is particularly important in polluted wound or body cavity that some can't keep clean.
5, soluble hemostatic cotton strengthens platelet function:
Behind bodily injury, platelet can be activated-and become sphere and stretch out pseudopodium by disc.They can discharge some enzymes and chemical substance in the granule of platelet, and enzyme can activate other platelet, and chemical substance then can promote platelet and blood vessel endothelium, collagen, glass, metal, fiber and adhesion to each other.Platelet aggregation is the platelet thrombosed character of adhering each other.
Soluble hemostatic cotton can promote platelet aggregation when fibrous being in, thereby promotes the formation of thrombosis.This process is similar to thrombocyte adhesiveness to impaired collagen protein.(this albumen is present under the endotheliocyte in connective tissue in a large number.)
6, soluble hemostatic cotton promotes coagulation process
Blood coagulation is meant that blood causes the activation of thrombin and Fibrinogen to be decomposed into fibrin and to form polymer from a unsettled relatively thrombosis state by the activated reaction of a series of complementary enzyme, thereby is transformed into the process of more stable coagulated state.This process can be that intrinsic pathway and extrinsic pathway are finished by two approach.
A. intrinsic pathway
All compositions that participate in the blood coagulation process all are present in the blood.Similarly, the required albumen of all coagulation process all is the part of intrinsic coagulation process.The effectiveness of intrinsic coagulation approach is tested by partial thromboplastin time and is estimated.
B. extrinsic pathway
This coagulation pathway is activated by tissue factor (blood vessel is ectogenic relatively), Gu the called after extrinsic pathway.Tissue factor and proconvertin are combined into complex, the co-activation Stuart factor.Remove outside the proconvertin, all compositions all are the ingredients of intrinsic pathway.Extrinsic pathway can be estimated by the test of carrying out prothrombin time.
(1) research has confirmed that PPT and PT can reduce (coagulation process quickening) when wound uses soluble hemostatic cotton.This explanation soluble hemostatic cotton all plays a role in two approach.
(2) intrinsic pathway is by some electronegative surface, and as glass, pottery, some synthetic plastics and fiber activate Hageman factor and start.They can activate Hageman factor, make it become enzyme form XIIa alive.When directly contacting when the soluble hemostatic cotton dissolving and with blood rbc, it can form electronegative colloid grain, thereby promotes the activation of Hageman factor.
(3) soluble hemostatic cotton can be by activating the formation of blood coagulation system promotion thrombin with contacting of extravascular tissue than many other the damage and blood of all fast blood vessel endothelium of hemorrhage onset.Thrombin can cause hematoblastic gathering.The platelet that contacts with thrombin can discharge particulate matter in the platelet in the blood plasma of periphery.Thrombin also can cause fibrinous gathering.Under study for action, the quality of soluble hemostatic cotton and initial solid state can reduce blood flow rate, thereby reduce the time that thrombin is discharged into wound.This is with the adhesion speed of platelet increasing and whole blood, thus promotion anthemorrhagic speed and function.
(4) enzyme of Hageman factor is lived, and form (a) Hageman factor is lived that (plasma thromboplastin antecedent a) for form by the catalysis plasma thromboplastin antecedent enzyme that is converted into it.Plasma thromboplastin antecedent a needs the participation of calcium ion when the plasma thromboplastin component activation is lived the form factor IXa for enzyme.Factor IXa with blood coagulation factor VIII after accumulate in the surface of cell membrane.The complex of factor IXa and blood coagulation factor VIII needs the participation of calcium ion could stablize they and the combining of film.Factor Xa and labile factor still need the participation of calcium ion when forming complex on the film surface.Under study for action, soluble hemostatic cotton can not only adhere to calcium ion, and since when dissolving surface area increase, it can enlarge the contact area of thrombin and calcium ion, thus increase blood coagulation efficient.
(5) thus the stable new clot that forms of formation that soluble hemostatic cotton can be by accelerating fibers protein-crosslinking body.
(6) soluble hemostatic cotton can significantly increase the viscosity of blood in the wound, thereby promotes erythrocytic gathering.Simultaneously, it helps to limit erythrocyte and hematoblastic loss, quickens hemostasis.Different with other materials that use in hemostasis, soluble hemostatic cotton also can increase the viscosity of blood on one's body the patient that the coagulation function defective is arranged.
The specific embodiment
Embodiment 1
(a) be raw material with degreasing cotton, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 50% and percetage by weight 5% as reactant liquor; bath raio is respectively to be put into closed stainless steel cask in 1: 58 and 1: 6.3 together and leaves standstill and carry out priming reaction; be generally 17:30 allotment before leaving offices; working every other day afterwards 8:00 is enabled, and can save the time of the energy and operation like this.
(b) raw material among a and reactant liquor are poured in the reactor together, poured into acid reaction liquid again in 70 ℃ of processing 6 hours, bath raio is carried out oxidation reaction at 1.7: 7, contain 60% chloroacetic acid in the said acid reaction liquid, 10% salicylic acid, 5% glycine, all the other are water.
(c) after the oxidation, the reactant liquor pH that is neutralized among the b with hydrochloric acid is 6.5 ~ 8.
(d) after the neutralization, the ethanol water with 75% is the degreasing cotton behind the cleaning reaction in industry washer, cleans repeatedly 3 times, until containing the sodium amount less than 10% percentage by weight.Dry then, oven dry, combing, shredding.
Embodiment 2
(a) be raw material with degreasing cotton, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 60% and percetage by weight 5.5% as reactant liquor, bath raio is respectively to be put into reactor in 1: 58 and 1: 6.3 together and carried out priming reaction in 2 hours in 40 ℃ of processing.
Remaining step is with embodiment 1, so no longer tell about.
Embodiment 3
(a) be raw material with degreasing cotton, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 60% and percetage by weight 5.5% as reactant liquor, bath raio is respectively to be put into reactor in 1: 58 and 1: 6.3 together and carried out priming reaction in 2 hours in 40 ℃ of processing.
(b) raw material among a and reactant liquor are poured in the reactor together, poured into acid reaction liquid again in 90 ℃ of processing 4 hours, bath raio is carried out oxidation reaction at 2.5: 7.7, contain 70% chloroacetic acid in the said acid reaction liquid, 10% salicylic acid, 5% glycine, all the other are water.
Remaining step is with embodiment 1, so no longer tell about.
The haemostatic effect test situation of product of the present invention is described below:
One, experiment purpose
Whether checking has anastalsis for test agent.
Two, being tried thing prepares
Get that to be tried thing an amount of, roll into a ball into diameter and be about little group about 6mm, on probation.
Three, tester preparation
Extracting degreasing absorbent cotton is an amount of, rolls into a ball into diameter and is about little group about 6mm, on probation.
Four, experimental animal
Rat, strain: SD, body weight: 300-330g, sex: male.
Source: Shanghai Slac Experimental Animal Co., Ltd..
Feeding environment is common experimental animal room, ambient temperature 20-25 ℃, and relative humidity 40-70%.
Five, instrument apparatus
Syringe, syringe needle, balance, stopwatch.
Six, experimental technique
Get 10 of rats, Ethylurethanm anesthesia back dorsal position is cut off the bilateral skin of lower extremity, passivity is separated exposure double side femoral vein and femoral artery, hemorrhage place covers placement respectively and is tried thing and tester in both sides behind the incision blood vessel, pick up counting simultaneously and observe hemorrhage situation, wipe the blood that oozes out around the covering gently away with absorbent cotton in addition.Wait not have when obvious blood oozes out and open covering gently, do not see hemorrhagely as wound, then record the time as bleeding stopping period.Still have blood to flow out as wound, then still continue to cover, opened covering every 20 seconds and observe, until stopped bleeding.Surpass 3 minutes still the haemophilia person count not hemorrhage.
Seven, result:
| In vain | 301.8 | 0.0560 | 105 | 0.0563 | 145 |
(s, X ± SD) 82.3 ± 27.8 to be tried the thing bleeding stopping period as calculated
(s, X ± SD) 94.2 ± 50.4 for the tester bleeding stopping period
Eight, interpretation of result
From the statistics angle, soluble hemostatic cotton has haemostatic effect.
In experimentation, we observe the wound big for amount of bleeding, that blood flow rate is high, and styptic cotton and absorbent cotton wool compare, and its instant haemostatic effect is relatively poor, but its chance blood has certain protective role to wound after turning to jelly.In a single day absorbent cotton wool is because of its fiber is long, cavity is many, so it is good with instant haemostatic effect to suck blood, but throws off from wound, wound begins again to bleed.
Soluble hemostatic cotton is covered in hemorrhage place after forming jelly, even throw off, still has certain protective role, and wound oozing of blood probability is reduced, and has certain hemostasis usefulness.
Being preferred embodiment of the present invention only in sum, is not to be used for limiting practical range of the present invention.Be that all equivalences of doing according to the content of the present patent application claim change and modification, all should be technology category of the present invention.
Claims (3)
1. soluble hemostatic cotton is characterized in that it prepares as follows:
Step 1: with degreasing cotton is raw material, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 50-60% and percetage by weight 5-5.5% as reactant liquor, bath raio is respectively to be put into reaction vessel together in 1: 58 and 1: 6.3 and carries out priming reaction;
Step 2: raw material in the step 1 and reactant liquor are poured in the reactor together, poured into acid reaction liquid again and carry out oxidation reaction;
Step 3: after the oxidation, the reactant liquor pH that is neutralized in the step 2 with hydrochloric acid is 6.5～8;
Step 4: after the neutralization, the ethanol water with 75% is the degreasing cotton behind the cleaning reaction in industry washer, cleans repeatedly 3 times, until containing the sodium amount less than 10% percentage by weight; Dry then, oven dry, combing, shredding;
The chloroacetic acid that contains 60-70% in the described step 2 in this acid reaction liquid, 10% salicylic acid, 5% glycine, all the other are water; Raw material and acid reaction liquid are according to bath raio 2.5: 7.7-1.7: 7 carry out oxidation reaction; Reaction temperature is 60-90 ℃, and the response time is 4-6 hour.
2. soluble hemostatic cotton according to claim 1, it is characterized in that in the described step 1 with degreasing cotton being raw material, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 50% and percetage by weight 5% as reactant liquor, bath raio is respectively to be put into closed stainless steel cask in 1: 58 and 1: 6.3 together and leaves standstill and carry out priming reaction.
3. soluble hemostatic cotton according to claim 1, it is characterized in that in the described step 1 with degreasing cotton being raw material, with raw material with the sodium hydrogen phosphate of the sodium hydrate aqueous solution of percetage by weight 60% and percetage by weight 5.5% as reactant liquor, bath raio is respectively to be put into reactor in 1: 58 and 1: 6.3 together and carried out priming reaction in 2 hours in 40 ℃ of processing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN200810038322XA CN101284144B (en) | 2008-05-30 | 2008-05-30 | Soluble hemostatic cotton |
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| CN200810038322XA CN101284144B (en) | 2008-05-30 | 2008-05-30 | Soluble hemostatic cotton |
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| CN101284144B true CN101284144B (en) | 2011-06-08 |
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| CN200810038322XA Expired - Fee Related CN101284144B (en) | 2008-05-30 | 2008-05-30 | Soluble hemostatic cotton |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102108637B (en) * | 2011-01-19 | 2012-06-27 | 刘建鸿 | Method for manufacturing soluble hemostatic cotton |
| CN102912618B (en) * | 2012-09-25 | 2014-10-22 | 北京维索科科技有限公司 | Production system for soluble hemostatic cotton |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286329A (en) * | 1999-08-30 | 2001-03-07 | 北京纺织科学研究所 | Water-soluble staltic cellulose fibre and its preparing process |
| JP2002369874A (en) * | 2001-06-14 | 2002-12-24 | Terumo Corp | Hemostatic material |
| CN1507843A (en) * | 2002-12-17 | 2004-06-30 | 中山生物工程有限公司 | Process for producing water-soluble hemostatic etamine |
| CN1799639A (en) * | 2005-12-31 | 2006-07-12 | 张博 | Inflammation-eliminating, pain-stopping, bacteria-resisting, pain-relieving soluble hemostatic gauze and its processing method |
-
2008
- 2008-05-30 CN CN200810038322XA patent/CN101284144B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286329A (en) * | 1999-08-30 | 2001-03-07 | 北京纺织科学研究所 | Water-soluble staltic cellulose fibre and its preparing process |
| JP2002369874A (en) * | 2001-06-14 | 2002-12-24 | Terumo Corp | Hemostatic material |
| CN1507843A (en) * | 2002-12-17 | 2004-06-30 | 中山生物工程有限公司 | Process for producing water-soluble hemostatic etamine |
| CN1799639A (en) * | 2005-12-31 | 2006-07-12 | 张博 | Inflammation-eliminating, pain-stopping, bacteria-resisting, pain-relieving soluble hemostatic gauze and its processing method |
Non-Patent Citations (1)
| Title |
|---|
| 于美丽等.可吸收止血材料的研究现状及临床应用.《北京生物医学工程》.2008,第27卷(第2期),208-211. * |
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