CN107617121A - A kind of skin wound biology induced activity dressing and its preparation method and application - Google Patents
A kind of skin wound biology induced activity dressing and its preparation method and application Download PDFInfo
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Abstract
The invention belongs to medical material technical field, and in particular to a kind of skin wound biology induced activity dressing and its preparation method and application.Skin wound biology induced activity dressing of the present invention includes following components and its parts by weight：Chitosan birds of the same feather flock together 18 22 parts of compound, 30 50 parts of sodium alginate, 59 parts of dilantin sodium, mix 200 300 parts of 12 18 parts of strontium borate biological activity glass, 5 10 parts of spirulina powder, 16 22 parts of ethanol, 13 17 parts of glycerine and water for injection.Skin wound biology induced activity dressing compatibility science provided by the invention, rationally, each component interacts, grow and heal for wound and optimum environment is provided, with significant antibacterial, anti-inflammatory and analgesic effect, in addition, bioactivity glass as carrier can not only control the rate of release of active ingredient in dressing, moreover it is possible to be effectively promoted wound healing, shorten healing time.
Description
Technical field
The invention belongs to medical material technical field, and in particular to a kind of skin wound biology induced activity dressing and its system
Preparation Method and application.
Background technology
Medical dressing refers to be covered on wound, has temporary protection to wound, prevents from infecting, promoting the medical material of healing
Material.Human body skin is maintenance homoiostasis and prevents the barrier of microorganism invasion, the skin caused by ulcer, burn etc.
Wound can cause a series of problems, and such as infection, the loss of moisture and immune system dysfunction, dressing typically pass through absorption
Exudate, keep surface of a wound moistening and by preventing that wound and growth of new tissue are good to be provided for wound reparation by germ contamination
Good environment.
The clinically conventional for example various gauzes of traditional dressing, cotton pad etc., more by the processing of cotton, lint and linen
Into, although wide material sources, cost are low, making is simple, to wound healing without be obviously promoted effect, its rough surface, drying, easily
Friction causes the surface of a wound further to damage, while the granulation tissue of surface of a wound growth is easily grown into the mesh of dressing, and drawing is pulled during dressing and is applied
Material easily causes pain and causes to damage the surface of a wound, and normal gauze water imbibition is poor, and oozing out more patient for the surface of a wound often needs
Repeatedly to change, increase clinical position amount, dressing fiber is also more easy to fall off, causes foreign body reaction.With to wound healing process
The research of middle pathophysiological mechanism deepens continuously, it was recognized that using the purpose of dressing not just to flap coverage, anti-
Only bleeding and infection, preferable dressing should be able to also have the effect of promoting wound healing.So in order in the protection surface of a wound
More efficiently promote wound healing simultaneously, the compositions such as medicine or EGF are added in many dressing, so as to turn into
Functional dressing.
Chinese patent application 105854069A disclose it is a kind of containing promote wound healing medicine alginate dressing and
Its preparation method, the alginate dressing include following components：50-99.9 parts alginate, 0.1-25 parts promote wound to be cured
Composite medicine and 0.01~15 part of surfactant；The invention, which contains, promotes the alginate dressing of wound healing medicine to can be used for more
The difficult surface of a wound and the tissue defect surface of a wound is closed, absorbs diffusate, there is provided wet environment needed for wound healing, wound can be effectively facilitated
Healing, but have much room for improvement the effect of its promotion wound healing.
Chinese patent application CN105079858A discloses a kind of wound sterilization and repairs liquid dressing and its preparation method, the wound
It is based on water soluble amino polysaccharide, disinfection preservative and high molecular polymer disinfection sanitizer that liquid dressing is repaired in mouth sterilization
Active component is wanted, the double emulsification system solution with sterilization repair function being made up of using macromolecule emulsifier emulsifying agent, both
Can promote wound healing, and can it is impervious go out, moreover it is possible to antibacterial anti-infection, be applicable the phases such as burn and scald, knife wound and the chronic infection surface of a wound
Close the flushing or soak treatment of the surface of a wound.But liquid dressing is in generally liquid liquid, stability is poor, more not square using process
Just, the requirement of people can not be met.
The content of the invention
In order to solve problems of the prior art, it is an object of the invention to provide a kind of skin wound biology to induce
Active dressing and its preparation method and application.Skin wound biology induced activity dressing compatibility science provided by the invention, rationally,
It is easy to use, there is the effect of significant anti-inflammatory, antibacterial and wound healing.
The invention provides a kind of skin wound biology induced activity dressing, including following components and its parts by weight：
Chitosan birds of the same feather flock together compound 18-22 parts, sodium alginate 30-50 parts, dilantin sodium 5-9 parts, mix strontium borate biological work
Property glass 12-18 parts, spirulina powder 5-10 parts, ethanol 16-22 parts, glycerine 13-17 parts and water for injection 200-300 parts.
Further, described skin wound biology induced activity dressing, is made up of following components and its parts by weight：
Chitosan birds of the same feather flock together 20 parts of compound, 40 parts of sodium alginate, 7 parts of dilantin sodium, mix strontium borate biological activity glass 15
Part, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerine and 250 parts of water for injection.
Further, the chitosan birds of the same feather flock together compound by carboxymethyl chitosan and chitosan hydrochloride by weight 2-4:1-
3 compositions.
Further, the chitosan birdss of the same feather flock together compound by carboxymethyl chitosan and chitosan hydrochloride by weight 3:2 groups
Into.
Further, the chemical constituent for mixing strontium borate biological activity glass is Na2O-K2O-MgO-CaO-B2O3-
SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：18：32：2：4.
Further, the particle diameter for mixing strontium borate biological activity glass is less than 10 μm.
In addition, present invention also offers a kind of preparation method of skin wound biology induced activity dressing, including following step
Suddenly：
S1, the water for injection for taking half amount, add chitosan compound of birdsing of the same feather flock together and be sufficiently stirred, add dilantin sodium, spirulina
Powder, stir, de-bubbled, move to sterilization treatment in sterilization tank, obtain mixture A；
S2, sodium alginate added into glycerine, in alcohol mixed solution, stirs, adds the water for injection of surplus, fill
Divide stirring, obtain mixture B；
S3, by mixture B obtained by mixture A, step S2 obtained by step S1 and mix strontium borate biological activity glass and mix
Uniformly, de-bubbled, plastic film mulch, dry, the sterilization treatment in sterilization tank, encapsulation, produce.
Further, sterilising temp is 115-135 DEG C in the step S1 and step S3.
Application of the described skin wound biology induced activity dressing in wound healing is also claimed in the present invention.
There is chitosan family macromolecule material performance, the dressing of the present invention such as moisture absorption, moisturizing, antibacterial, hemostasis to utilize carboxymethyl
Chitosan and chitosan hydrochloride compounding shitosan macromolecule, cooperateed with components such as spirulina powder, dilantin sodiums play it is antibacterial,
Anti-inflammatory and analgesic effect, find skin wound biology induced activity dressing of the present invention to staphylococcus aureus, B-mode through experiment
Hemolytic streptococcus, Pseudomonas aeruginosa and Candida albicans are respectively provided with significant inhibitory action；Found through anti-inflammation test, with control group
Compare, skin wound biology induced activity dressing prepared by the present invention can significantly reduce the ear method of double differences of mouse, have preferable
Anti-inflammatory effects, and its anti-inflammatory effects is better than Compound Dexamethasone Cream.In addition, skin wound biology induced activity of the present invention applies
Material also added mixes strontium borate biological activity glass as carrier with good biodegradability properties energy and bioactivity, and one
It can control the rate of release of active ingredient in dressing to aspect, on the other hand its can be very good to adsorb blood platelet, blood plasma in
Wherein, generation, the growth of the multiplication capacity and promotion granulation tissue and epithelial tissue that improve cell for promoting growth factor, more
Be advantageous to the healing of the surface of a wound.
Compared with prior art, the technical advantages of the present invention are that：
(1) skin wound biology induced activity dressing of the present invention has antibacterial, anti-inflammatory and analgesic effect, can effectively mitigate
The pain of patient.(2) skin wound biology induced activity dressing of the present invention is easy to use, and it is strong to absorb the ability of diffusate, does not glue
Even wound, has stronger performance of keeping humidity.(3) skin wound biology induced activity dressing of the present invention promote wound healing effect compared with
It is good, wherein most fast healing time is 13 days.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art according to the present invention basic thought, various modifications may be made or improve, but without departing from this
The basic thought of invention, within the scope of the present invention.
In the present invention, mix strontium borate biological activity glass has purchased from Xiao Te (Shanghai) precise materials and equipment international trade
Limit company；Carboxymethyl chitosan CAS：83512-85-0；Chitosan hydrochloride CAS：70694-72-3；Sodium alginate CAS：630-
93-3；Spirulina powder CAS：724424-92-4.
Embodiment 1, a kind of skin wound biology induced activity dressing
The skin wound biology induced activity dressing is made up of following components and its parts by weight：
Chitosan birds of the same feather flock together 18 parts of compound, 50 parts of sodium alginate, 9 parts of dilantin sodium, mix strontium borate biological activity glass 12
Part, 10 parts of spirulina powder, 22 parts of ethanol, 13 parts of glycerine and 200 parts of water for injection；The chitosan birdss of the same feather flock together compound by carboxymethyl shell
Glycan and chitosan hydrochloride are by weight 2:1 composition；The chemical constituent for mixing strontium borate biological activity glass is Na2O-
K2O-MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：18：32：2：4.
Preparation method：
S1, the water for injection for taking half amount, add chitosan compound of birdsing of the same feather flock together and be sufficiently stirred, add dilantin sodium, spirulina
Powder, stir, de-bubbled, move to sterilization treatment in 115 DEG C of sterilization tanks, obtain mixture A；
S2, sodium alginate added into glycerine, in alcohol mixed solution, stirs, adds the water for injection of surplus, fill
Divide stirring, obtain mixture B；
S3, by mixture B obtained by mixture A, step S2 obtained by step S1 and mix strontium borate biological activity glass and mix
Uniformly, de-bubbled, plastic film mulch, dry, the sterilization treatment in 115 DEG C of sterilization tanks, encapsulation, produce.
Embodiment 2, a kind of skin wound biology induced activity dressing
The skin wound biology induced activity dressing is made up of following components and its parts by weight：
Chitosan birds of the same feather flock together 20 parts of compound, 40 parts of sodium alginate, 7 parts of dilantin sodium, mix strontium borate biological activity glass 15
Part, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerine and 250 parts of water for injection.The chitosan birdss of the same feather flock together compound by carboxymethyl shell
Glycan and chitosan hydrochloride are by weight 3:2 compositions；The chemical constituent for mixing strontium borate biological activity glass is Na2O-
K2O-MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：18：32：2：4.
Preparation method：
S1, the water for injection for taking half amount, add chitosan compound of birdsing of the same feather flock together and be sufficiently stirred, add dilantin sodium, spirulina
Powder, stir, de-bubbled, move to sterilization treatment in 125 DEG C of sterilization tanks, obtain mixture A；
S2, sodium alginate added into glycerine, in alcohol mixed solution, stirs, adds the water for injection of surplus, fill
Divide stirring, obtain mixture B；
S3, by mixture B obtained by mixture A, step S2 obtained by step S1 and mix strontium borate biological activity glass and mix
Uniformly, de-bubbled, plastic film mulch, dry, the sterilization treatment in 125 DEG C of sterilization tanks, encapsulation, produce.
Embodiment 3, a kind of skin wound biology induced activity dressing
The skin wound biology induced activity dressing is made up of following components and its parts by weight：
Chitosan birds of the same feather flock together 22 parts of compound, 30 parts of sodium alginate, 5 parts of dilantin sodium, mix strontium borate biological activity glass 18
Part, 5 parts of spirulina powder, 16 parts of ethanol, 17 parts of glycerine and 300 parts of water for injection；The chitosan birdss of the same feather flock together compound by carboxymethyl shell
Glycan and chitosan hydrochloride are by weight 4:3 compositions；The chemical constituent for mixing strontium borate biological activity glass is Na2O-
K2O-MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：18：32：2：4.
Preparation method：
S1, the water for injection for taking half amount, add chitosan compound of birdsing of the same feather flock together and be sufficiently stirred, add dilantin sodium, spirulina
Powder, stir, de-bubbled, move to sterilization treatment in 135 DEG C of sterilization tanks, obtain mixture A；
S2, sodium alginate added into glycerine, in alcohol mixed solution, stirs, adds the water for injection of surplus, fill
Divide stirring, obtain mixture B；
S3, by mixture B obtained by mixture A, step S2 obtained by step S1 and mix strontium borate biological activity glass and mix
Uniformly, de-bubbled, plastic film mulch, dry, the sterilization treatment in 135 DEG C of sterilization tanks, encapsulation, produce.
Comparative example 1, a kind of skin wound biology induced activity dressing
The skin wound biology induced activity dressing is made up of following components and its parts by weight：
Chitosan birds of the same feather flock together 20 parts of compound, 40 parts of sodium alginate, 7 parts of dilantin sodium, mix strontium borate biological activity glass 15
Part, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerine and 250 parts of water for injection；The chitosan birdss of the same feather flock together compound by carboxymethyl shell
Glycan and chitosan hydrochloride are by weight 1:1 composition；The chemical constituent for mixing strontium borate biological activity glass is Na2O-
K2O-MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：18：32：2：4.
Preparation method is similar to Example 2.
Difference with embodiment 2 is, the chitosan birds of the same feather flock together compound by carboxymethyl chitosan and chitosan hydrochloride by
Weight is than 1:1 composition.
Comparative example 2, a kind of skin wound biology induced activity dressing
The skin wound biology induced activity dressing is made up of following components and its parts by weight：
Chitosan birds of the same feather flock together 20 parts of compound, 40 parts of sodium alginate, 7 parts of dilantin sodium, mix strontium borate biological activity glass 15
Part, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerine and 250 parts of water for injection；The chitosan birdss of the same feather flock together compound by carboxymethyl shell
Glycan and chitosan hydrochloride are by weight 3:2 compositions；The chemical constituent for mixing strontium borate biological activity glass is Na2O-
K2O-MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：20：32：2：2.
Preparation method is similar to Example 2.
Difference with embodiment 2 is that the chemical constituent for mixing strontium borate biological activity glass is Na2O-K2O-
MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：8：8：22：20：32：2：2, that is, add B2O3Mole
Number, reduce SrO molfraction.
Test example one, skin wound biology induced activity dressing extracorporeal bacteria inhibitor test
1. test material：Skin wound biology induced activity dressing prepared by 1-3 of the embodiment of the present invention and comparative example 1-2.
2. test method：
Preparation for trying bacterium solution：Respectively by staphylococcus aureus, beta hemolytic streptococcus, green in sterile room
Purulence bacillus and Candida albicans are seeded in beef extract nutrient solution, and cellar culture is carried out under the conditions of 28-30 DEG C.
Diffusion method is punched using agar, sterile petri dish is divided into 5 groups, every group 4, each sterile petri dish pours into sterilizing
Beef extract nutrient solution 15-20mL afterwards, 0.1mL staphylococcus aureuses, B-mode molten are drawn with Sterile pipette after its solidification
Courageous and upright streptococcus, Pseudomonas aeruginosa and Candida albicans are added on culture dish for examination bacterium solution, and coating is uniform, each culture in every group
Ware is separately added into different strains.
After coating, 5 equidistant holes are then made a call on culture medium with external diameter 4mm sterilizing stainless steel card punch.
The embodiment 1-3 and comparative example 1-2 skin wound biology induced activity dressing prepared is completely dissolved with sterilized water, added with micro
Sample device distinguishes the extraction embodiment 1-3 and μ l of comparative example 1-2 skin wound biology induced activitys dressing solution 30, middle hole addition
Normal saline does control group, carries out mark.Bacterium is placed at 38 DEG C and cultivates 24h, measures antibacterial circle diameter (bacteriostatic diameter
Mm is counted), experiment is repeated 3 times, and is averaged.
3. result of the test：Test result is as shown in table 1.
The bacteriostatic test data of the skin wound biology induced activity dressing of table 1
As shown in Table 1, the skin wound biology induced activity dressing that prepared by the present invention is to the antibacterial of staphylococcus aureus
Diameter is more than 23.8mm, is more than 32.1mm to the bacteriostatic diameter of beta hemolytic streptococcus, big to the bacteriostatic diameter of Pseudomonas aeruginosa
In 34.1mm, 30.3mm is more than to the staphylococcic bacteriostatic diameter of white, i.e., to staphylococcus aureus, hemolytic hammer
Bacterium, Pseudomonas aeruginosa and Candida albicans are respectively provided with significant inhibitory action, and comparative example 1-2 skin wound biology induced activitys apply
Effect of the fungistatic effect of material than embodiment of the present invention 1-3 has obvious difference, illustrate dressing each component compatibility science of the present invention,
Rationally, bacteriostasis is preferable.
Test example two, skin wound biology induced activity dressing anti-inflammation test
1. subjects：60 Male Kunming strain mices, body weight 40-50g.
2. test material：Skin wound biology induced activity dressing prepared by 1-3 of the embodiment of the present invention and comparative example 1, it is multiple
Square Dexamethasone Cream, it is purchased from the laborsaving victory pharmaceutical Co. Ltd in Jilin, Chinese medicines quasi-word H84202427.
3. test method：
60 mouse are randomly divided into 6 groups, every group 10, respectively control group, Dexamethasone group, embodiment 1-3 groups, right
1 group of ratio, dimethylbenzene 50 μ l uniformly being applied on the auris dextra of every group of mouse, left ear compares, after causing scorching 2h, the mouse to each group
Auris dextra coats following medicine, and it is as follows to apply dose：
Control group：Smear physiological saline；Dexamethasone group：Smear Compound Dexamethasone Cream；1 group of embodiment：Smear 1g/
Skin wound biology induced activity dressing prepared by ml embodiments 1；2 groups of embodiment：Smear skin prepared by 1g/ml embodiments 2
Surface of a wound biology induced activity dressing；3 groups of embodiment：Skin wound biology induced activity prepared by 1g/ml embodiments 3 is smeared to apply
Material；1 group of comparative example：Smear skin wound biology induced activity dressing prepared by 1g/ml comparative examples 1.
Vertebra execution is taken off after smearing medicine 10h, two ears are cut along auricle, with 8mm card punch respectively at the same position of left and right ear
Round auricle is laid, is weighed, calculates the ear method of double differences, the ear method of double differences=auris dextra circle auricle weight-left ear circle auricle weight.
4th, result of the test：Result of the test is as shown in table 2.
The influence that the skin wound biology induced activity dressing of table 2 swells to mouse auricular concha caused by dimethylbenzene xylene
| Group | N/ is only | The ear method of double differences/mg |
| Control group | 10 | 8.21±1.23 |
| Dexamethasone group | 10 | 5.13±0.52** |
| 1 group of embodiment | 10 | 4.42±0.95**a |
| 2 groups of embodiment | 10 | 3.98±0.76**a |
| 3 groups of embodiment | 10 | 4.36±0.68**a |
| 1 group of comparative example | 10 | 5.41±1.12** |
Note：* and control group ratio, there is pole significant difference (P ＜ 0.01)；A and 1 group of ratio of comparative example, there is significant difference (P
＜ 0.05).
As shown in Table 2, compared with control group, embodiment 1-3 groups can significantly decrease the ear method of double differences of mouse, have preferable
Antiinflammation, and its anti-inflammatory effects is better than Compound Dexamethasone Cream, and the effect of wherein embodiment 2 is best, for the present invention
Most preferred embodiment；Compared with 1 group of comparative example, the embodiment of the present invention 2 prepares the anti-inflammatory of skin wound biology induced activity dressing
Effect has significant difference, illustrates that the chitosan of carboxymethyl chitosan and chitosan hydrochloride of the present invention compounding is birdsed of the same feather flock together compound
Mutually cooperateed with each component, there is significant antiinflammatory action.
Test example three, the experiment of skin wound biology induced activity dressing wound healing
1. subjects：50 Male Kunming strain mices, body weight 40-50g.
2. test material：Skin wound biology induced activity dressing prepared by 1-3 of the embodiment of the present invention, skin wound dressing
(removing without strontium borate biological activity glass is mixed, remaining is same as Example 2).
3. test method：
50 mouse are randomly divided into 5 groups, every group 10, respectively control group, skin wound dressing group, embodiment 1-3
Group.After 5 groups of rat abdomen injecting anesthetics, in the back both sides production machinery full thickness skin surface of a wound, surface of a wound diameter 2cm, depth and skin
Lower muscular fascia, is stopped blooding with sterile gauze, and coating process is as follows：
Control group is loaded into gauze flap coverage with 0.5mL physiological saline；Embodiment 1-3 groups and skin wound dressing composition are other
Coat prepare dressing, the next day change.
Wound healing rate is determined in 5d, 10d, Wound healing rate=(initial surface of a wound area-do not heal surface of a wound area)/just
Firstly appear face area × 100%.And record wound healing time, wound healing time be evaluate wound healing traditional index it
One, the time needed for the complete epithelialization of the surface of a wound is defined as, epithelialization is relied on and visually observed.
4th, result of the test：Result of the test is as shown in table 3.
The wounds in mice healing state of table 3
Note：* with control group ratio, there is significant difference (P ＜ 0.05)；* and control group ratio, there is pole significant difference (P ＜
0.01)；A and skin wound dressing group ratio, there is significant difference (P ＜ 0.05)；Aa and skin wound dressing group ratio, have extremely notable
Sex differernce (P ＜ 0.01).
As shown in Table 3, the skin wound biology induced activity dressing that prepared by the present invention promotes the significant effect of wound healing.
Compared with control group, the mouse wound healing rate using skin wound biology induced activity dressing of the present invention is higher, healing time
Short, the effect of wherein embodiment 2 is best, and healing time is 13 days, is highly preferred embodiment of the present invention；With skin wound dressing group
To compare, skin wound biology induced activity dressing prepared by the embodiment of the present invention 2 has conspicuousness to promotion mouse wound healing,
Illustrate that the formula of skin wound biology induced activity dressing prepared by the present invention is reasonable, mixing strontium borate biological activity glass has
The obvious effect for promoting wound healing.
Claims (9)
1. a kind of skin wound biology induced activity dressing, it is characterised in that including following components and its parts by weight：
Chitosan birds of the same feather flock together compound 18-22 parts, sodium alginate 30-50 parts, dilantin sodium 5-9 parts, mix strontium borate biological activity glass
Glass 12-18 parts, spirulina powder 5-10 parts, ethanol 16-22 parts, glycerine 13-17 parts and water for injection 200-300 parts.
2. skin wound biology induced activity dressing according to claim 1, it is characterised in that by following components and its again
Measure number composition：
Chitosan birds of the same feather flock together 20 parts of compound, 40 parts of sodium alginate, 7 parts of dilantin sodium, mix 15 parts of strontium borate biological activity glass, spiral shell
250 parts of 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerine and water for injection.
3. skin wound biology induced activity dressing according to claim 1 or 2, it is characterised in that the chitosan class
Polymer is by carboxymethyl chitosan and chitosan hydrochloride by weight 2-4:1-3 is formed.
4. skin wound biology induced activity dressing according to claim 3, it is characterised in that the chitosan Type of Collective
Thing is by carboxymethyl chitosan and chitosan hydrochloride by weight 3:2 compositions.
5. skin wound biology induced activity dressing according to claim 1 or 2, it is characterised in that described to mix strontium boric acid
The chemical constituent of salt bioactivity glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5- SrO, each component mol ratio are 6：
8：8：22：18：32：2：4.
6. skin wound biology induced activity dressing according to claim 5, it is characterised in that described to mix the life of strontium borate
The particle diameter of thing activity glass is less than 10 μm.
7. the preparation method of the skin wound biology induced activity dressing according to claim any one of 1-6, its feature exist
In comprising the following steps：
S1, the water for injection for taking half amount, add chitosan compound of birdsing of the same feather flock together and be sufficiently stirred, add dilantin sodium, spirulina powder, stir
Mix uniformly, de-bubbled, move to sterilization treatment in sterilization tank, obtain mixture A；
S2, sodium alginate added into glycerine, in alcohol mixed solution, stirs, adds the water for injection of surplus, fully stir
Mix, obtain mixture B；
S3, by mixture B obtained by mixture A, step S2 obtained by step S1 and mix strontium borate biological activity glass and be well mixed,
De-bubbled, plastic film mulch, dry, the sterilization treatment in sterilization tank, encapsulation, produce.
8. the preparation method of skin wound biology induced activity dressing according to claim 7, it is characterised in that the step
Sterilising temp is 115-135 DEG C in rapid S1 and step S3.
9. application of the skin wound biology induced activity dressing according to claim 1 or 2 in wound healing.
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| WO2019148554A1 (en) * | 2018-02-01 | 2019-08-08 | 福州瑞克布朗医药科技有限公司 | Boron and phosphorus-based bioactive glass and preparation method thereof |
| WO2020113474A1 (en) * | 2018-12-05 | 2020-06-11 | 中国科学院深圳先进技术研究院 | Polyurethane sponge material, preparation method therefor, use thereof and polyurethane sponge article |
| CN113230446A (en) * | 2021-04-30 | 2021-08-10 | 海南鸿翼医疗器械有限公司 | Inorganic functional dressing for stopping bleeding and promoting healing of skin wound and preparation method thereof |
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| CN116354599A (en) * | 2023-04-06 | 2023-06-30 | 深圳先进技术研究院 | Boron-containing bioactive glass and preparation method and application thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341203A (en) * | 2013-06-24 | 2013-10-09 | 张延海 | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster |
| CN103520764A (en) * | 2013-10-29 | 2014-01-22 | 成都迪康中科生物医学材料有限公司 | Functional dressing, and preparation method and application thereof |
| WO2014027906A1 (en) * | 2012-08-17 | 2014-02-20 | Politechnika Łódzka | Biodegradable textiles and methods of their manufacture |
| CN103705968A (en) * | 2013-12-30 | 2014-04-09 | 深圳先进技术研究院 | Medical chitosan compound moisturizing dressing and preparation method thereof |
| CN103736135A (en) * | 2013-12-12 | 2014-04-23 | 深圳先进技术研究院 | Medicinal composite dressing and preparation method thereof |
| CN103848574A (en) * | 2012-12-06 | 2014-06-11 | 上海诺帮生物科技有限公司 | Preparation of strontium-containing bioglass powder and preparation method of strontium-containing porous bioglass bracket |
| CN105833339A (en) * | 2016-03-25 | 2016-08-10 | 广州瑞辉生物科技股份有限公司 | Medical functional chitosan dressing and preparation method thereof |
| CN105854069A (en) * | 2016-06-02 | 2016-08-17 | 四川奎星医用高分子制品有限责任公司 | Alginate dressing containing wound-healing promoting medicine and preparing method thereof |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN106215232A (en) * | 2016-08-29 | 2016-12-14 | 重庆理工大学 | A kind of wound antibacterial promoting healing dressing and preparation method thereof |
| CN107029272A (en) * | 2017-04-10 | 2017-08-11 | 河南汇博医疗股份有限公司 | A kind of alginate medical dressing and preparation method thereof |
-
2017
- 2017-10-13 CN CN201710950554.1A patent/CN107617121B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014027906A1 (en) * | 2012-08-17 | 2014-02-20 | Politechnika Łódzka | Biodegradable textiles and methods of their manufacture |
| CN103848574A (en) * | 2012-12-06 | 2014-06-11 | 上海诺帮生物科技有限公司 | Preparation of strontium-containing bioglass powder and preparation method of strontium-containing porous bioglass bracket |
| CN103341203A (en) * | 2013-06-24 | 2013-10-09 | 张延海 | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster |
| CN103520764A (en) * | 2013-10-29 | 2014-01-22 | 成都迪康中科生物医学材料有限公司 | Functional dressing, and preparation method and application thereof |
| CN103736135A (en) * | 2013-12-12 | 2014-04-23 | 深圳先进技术研究院 | Medicinal composite dressing and preparation method thereof |
| CN103705968A (en) * | 2013-12-30 | 2014-04-09 | 深圳先进技术研究院 | Medical chitosan compound moisturizing dressing and preparation method thereof |
| CN105833339A (en) * | 2016-03-25 | 2016-08-10 | 广州瑞辉生物科技股份有限公司 | Medical functional chitosan dressing and preparation method thereof |
| CN105854069A (en) * | 2016-06-02 | 2016-08-17 | 四川奎星医用高分子制品有限责任公司 | Alginate dressing containing wound-healing promoting medicine and preparing method thereof |
| CN106075556A (en) * | 2016-06-02 | 2016-11-09 | 四川奎星医用高分子制品有限责任公司 | Containing the medical recombination chitosan gel promoting wound healing medicine |
| CN106215232A (en) * | 2016-08-29 | 2016-12-14 | 重庆理工大学 | A kind of wound antibacterial promoting healing dressing and preparation method thereof |
| CN107029272A (en) * | 2017-04-10 | 2017-08-11 | 河南汇博医疗股份有限公司 | A kind of alginate medical dressing and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| SHUANGSHUANG LI ET AL: "A promising wound dressing material with excellent cytocompatibility and proangiogenesis action for wound healing:Strontium loaded Silk fibroin/Sodium alginate (SF/SA) blend films", 《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》 * |
| 曹烨民主编: "《周围血管病中医小丛书 糖尿病下肢病变中医治疗思路》", 30 September 2015, 北京：中国中医药出版社 * |
| 王锦鸿等: "《临床实用中药辞典》", 30 November 2003, 北京：金盾出版社 * |
| 赵寅生等: "含锶硼硅酸盐生物玻璃的降解性能及体外生物活性", 《功能材料》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019148554A1 (en) * | 2018-02-01 | 2019-08-08 | 福州瑞克布朗医药科技有限公司 | Boron and phosphorus-based bioactive glass and preparation method thereof |
| CN109550071A (en) * | 2018-12-05 | 2019-04-02 | 中国科学院深圳先进技术研究院 | Polyurethane sponge material and preparation method thereof, application and polyurethane sponge product |
| WO2020113474A1 (en) * | 2018-12-05 | 2020-06-11 | 中国科学院深圳先进技术研究院 | Polyurethane sponge material, preparation method therefor, use thereof and polyurethane sponge article |
| CN109550071B (en) * | 2018-12-05 | 2021-08-24 | 中国科学院深圳先进技术研究院 | Polyurethane sponge material, preparation method and application thereof, and polyurethane sponge product |
| CN113230446A (en) * | 2021-04-30 | 2021-08-10 | 海南鸿翼医疗器械有限公司 | Inorganic functional dressing for stopping bleeding and promoting healing of skin wound and preparation method thereof |
| CN113698560A (en) * | 2021-09-13 | 2021-11-26 | 深圳先进技术研究院 | Antibacterial and anti-inflammatory composite hydrogel precursor solution and preparation method and application thereof |
| CN113698560B (en) * | 2021-09-13 | 2024-01-26 | 深圳先进技术研究院 | Antibacterial and anti-inflammatory composite hydrogel precursor liquid and preparation method and application thereof |
| CN116354599A (en) * | 2023-04-06 | 2023-06-30 | 深圳先进技术研究院 | Boron-containing bioactive glass and preparation method and application thereof |
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