CN109331219A - A kind of chitosan liquid dressing - Google Patents

Abstract

This application involves a kind of chitosan liquid dressings, the film forming agent of cleaning agent and liquid including liquid, and cleaning agent is separately positioned with film forming agent；Cleaning agent and film forming agent all have constituent of chitosan；Wherein, it is 0.5%~5% constituent of chitosan that cleaning agent, which has mass ratio,；It is 2%~12% constituent of chitosan that film forming agent, which has mass ratio,.On the one hand the design that cleaning agent and film forming agent are liquid is used, when use is very convenient, and spray pattern application, which both can be used, also can be used application pattern application；On the other hand the constituent of chitosan of different quality ratio is used to realize cleaning, sterilization, isolation and protection effect；Another aspect uses the design that cleaning agent is separated with film forming agent, and wound cleaning can be realized only with cleaning agent, then realizes wound isolating and protecting using film forming agent；Another further aspect can retain the diffusate of wound, moist environment needed for providing quick healing of cut during debridement forms a film, to be conducive to wound recovery.

Description

A kind of chitosan liquid dressing

Technical field

This application involves medical material fields, more particularly to a kind of chitosan liquid dressing.

Background technique

Chitosan (Chitosan) is also known as chitosan, is chitin (Chitin) warp being widely present by nature Cross what deacetylation obtained, chemical name is Chitosan (1-4) -2- amino-B-D glucose.From 1859, Frenchman After Rouget obtains chitosan first, the biological functionality and compatibility of this natural polymer, blood compatibility, safety, The excellent performances such as microbic resolvability are by all trades and professions extensive concern, in medicine, food, chemical industry, cosmetics, water process, metal It extracts and the application study of the numerous areas such as recycling, biochemical and biomedical engineering achieves major progress.For patient, shell is poly- Sugared reducing blood lipid, hypoglycemic effect existing research report.Meanwhile chitosan is included in state food as thickener, fruit glaze agent Additive uses standard GB-2760.Chitosan is the product that chitin takes off N- acetyl group, it is however generally that, N- acetyl group is sloughed 55% or more can be referred to as chitosan, in other words, 1% deacetylated crust can be dissolved in 1% acetic acid or 1% hydrochloric acid Element, this chitosan are referred to as chitosan.Deacetylation degree determines amido (NH on macromolecular chain₂) content How much, and deacetylation degree increases, and increases chitosan charged group in dilute acid soln since amido protonates, gathers Electrolyte charge density increases, and result will lead to its structure, the variation in property and performance.

Medical dressing is the cladding wound i.e. articles of wound, including natural gauze, the dressing of synthetic fibers class, poly film class are applied Material, foaming multi-cluster dressing, the dressing of hydrocolloid class, alginate dressing etc., to cover the medical material of sore, wound or other damages Material.With the physiopathologic further investigation to wound, people are also deeper and deeper to the understanding of wound It carves, continuously improving and develop so as to cause Medical wounded surface dressing.Liquid dressing is one kind of Medical dressing, is belonged to outer Section's medication preparation, usually exists in liquid form, is applied to wound surface by coating or spray pattern, in the process, Liquid dressing is applied to wound surface with the way of contact or cordless by the instrument of applicating liquid dressing, to reach expected work With the predictive role includes but is not limited to cleaning, sterilization, isolation, protection, administration and/or nutrition etc., for example, liquid dressing Protective layer is formed in wound surface to play the role of physical barriers.With technological progress, various novel liquid dressings are increasingly Increasing, liquid dressing is widely used in the nursing of the shallows surface of a wound such as small wound mouth, scratch, incised injury and its surrounding skin, and And it is suitable for the surface wound infection control of human body and promotes the ranges such as wound healing.With technical research, it is related to chitosan There are many patent documents for liquid dressing, are described as follows.

For example, the Chinese patent of Publication No. CN104147632A discloses a kind of chitosan shield of specific cell adhesion Liquid dressing and preparation method thereof is created, the chitosan graft of high relative molecular mass (100,000 or more) is had cell special by the present invention The polypeptide RGD (arginine, glycine and aspartic acid sequence) of opposite sex adherency, and pass through γ under the action of molecular weight regulator A kind of low-molecular weight chitoglycan Wound-protection liquid body dressing of specific cell adhesion is prepared in x ray irradiation x degradation technique.The present invention For the sterilization of clinically wound, hemostasis and pain-relieving, antipruritic, promotion healing.The present invention has cell-specific identification adherency, avoids different Body rejection, biocompatibility are good, have wide range of applications, and preparation process is simply controllable, reproducible feature.

For another example, the Chinese patent of Publication No. CN108144107A discloses liquid dressing for wound cleaning, belongs to wound Mouth inorganic agent technical field.The dressing of fluid present invention cleaning wound is made of substance below: poly hexamethylene biguanide 0.1-0.3 Part, 2.1-2.4 parts of sodium chloride, 0.1-0.3 parts of potassium chloride, 0.05-0.4 parts of vitamin C, 2-3 parts of chitosan, wormwood 0.1-0.5 Part, 1-3 parts of aloe, 0.1-0.5 parts of peppermint, 93-95 parts of deionized water.The present invention does not contain hormone, as promotion wound healing Drug use, can make wound heal rapidly, and wound can be cleared up.

For another example, the Chinese patent of Publication No. CN107233617A discloses a kind of liquid chitosan wound dressing and its system It is standby with application, which is made of the following raw material: it is dense that N- glycosylates chitosan, aloe extract, quality Spend 10% polyvinyl alcohol water solution, polyethylene glycol, glycerol, olive oil, povidone iodine, 30% hydrogen peroxide of mass concentration, lactic acid, thin Lotus brain, 95% ethanol water of volumetric concentration, 5mg/mL physiological saline；The fluid wound dressing of smear type of the invention is suitable for Skin abrasion incised wound, chapped skin, slight burn and scald, protection of surgical site infections suture site etc..

But what the liquid dressing for being related to chitosan of traditional technology can not be combined in film-formation result and flushing effect presence Design defect.

Summary of the invention

Based on this, it is necessary to provide a kind of chitosan liquid dressing.

A kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid, and the cleaning agent and institute It is separately positioned to state film forming agent；The cleaning agent and the film forming agent all have constituent of chitosan；Wherein, the cleaning agent has matter The constituent of chitosan that amount ratio is 0.5%~5%；It is 2%~12% constituent of chitosan that the film forming agent, which has mass ratio,.

Above-mentioned chitosan liquid dressing, on the one hand uses the design that cleaning agent and film forming agent are liquid, and when use is non- Often convenient, spray pattern application, which both can be used, also can be used application pattern application；On the other hand different quality ratio is used Constituent of chitosan realizes cleaning, sterilization, isolation and protection effect；Another aspect is set using what cleaning agent was separated with film forming agent Meter can realize wound cleaning only with cleaning agent, then realize wound isolating and protecting using film forming agent；Another further aspect can be Debridement retains the diffusate of wound, moist environment needed for providing quick healing of cut, to be conducive to create during forming a film Mouth restores.

The cleaning agent is the physiological saline with constituent of chitosan in one of the embodiments,.

It is 0.01%~0.05% that the cleaning agent, which is the mass ratio with constituent of chitosan, in one of the embodiments, Benza.

The cleaning agent is the second that the volume ratio with constituent of chitosan is 70%~75% in one of the embodiments, Alcoholic solution.

It is 1%~4% constituent of chitosan that the cleaning agent, which has mass ratio, in one of the embodiments,.

It is 3%~10% constituent of chitosan that the film forming agent, which has mass ratio, in one of the embodiments,.

The film forming agent is Watery film-fomer in one of the embodiments,.

The film forming agent is selected from albumen film forming agent, acrylic resin film forming agent, polyethylene kind in one of the embodiments, One of copolymer, hydrocarbon type copolymer, organosilicon polymer or Si acrylate are a variety of.

The constituent of chitosan is selected from chitosan, organic selenium molecular chitosan derivative, shell in one of the embodiments, One of glycan quaternary ammonium salt, chitosan hydrochloride, chitosan alginates or carboxymethyl chitosan are a variety of.

The cleaning agent and the film forming agent have different constituent of chitosan in one of the embodiments,.

Specific embodiment

In order to make the above objects, features, and advantages of the present application more apparent, below to the specific reality of the application The mode of applying is described in detail.Many details are explained in the following description in order to fully understand the application.But The application can be implemented with being much different from other way described herein, and those skilled in the art can be without prejudice to this Shen Similar improvement please be done in the case where intension, therefore the application is not limited by the specific embodiments disclosed below.

It should be noted that it can be directly another when element is referred to as " being fixed on " or " being set to " another element On one element or there may also be elements placed in the middle.When an element is considered as " connection " another element, it can be with It is directly to another element or may be simultaneously present centering elements.Term as used herein " vertically ", " level ", "left", "right" and similar statement for illustrative purposes only, be not meant to be the only embodiment.

Unless otherwise defined, all technical and scientific terms used herein and the technical field for belonging to the application The normally understood meaning of technical staff is identical.The term used in the description of the present application is intended merely to description tool herein The purpose of the embodiment of body, it is not intended that in limitation the application.Term as used herein "and/or" includes one or more Any and all combinations of relevant listed item.

In the application one embodiment, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming of liquid Agent, and the cleaning agent and the film forming agent are separately positioned；The cleaning agent and the film forming agent all have constituent of chitosan；Its In, it is 0.5%~5% constituent of chitosan that the cleaning agent, which has mass ratio,；It is 2% that the film forming agent, which has mass ratio, ~12% constituent of chitosan.On the one hand above-mentioned chitosan liquid dressing uses cleaning agent and film forming agent is setting for liquid Meter, when use, are very convenient, and spray pattern application, which both can be used, also can be used application pattern application；On the other hand difference is used The constituent of chitosan of mass ratio realizes cleaning, sterilization, isolation and protection effect；Another aspect uses cleaning agent and film forming The design of agent separation can realize wound cleaning only with cleaning agent, then realize wound isolating and protecting using film forming agent；Further Aspect can debridement form a film during retain wound diffusate, moist environment needed for quick healing of cut is provided, from And be conducive to wound recovery.

It is 1%~4% constituent of chitosan that the cleaning agent, which has mass ratio, in one of the embodiments,.At it In middle one embodiment, it is 3%~10% constituent of chitosan that the film forming agent, which has mass ratio,.One embodiment wherein In, it is 2%~4% constituent of chitosan that the cleaning agent, which has mass ratio,；The cleaning agent in one of the embodiments, The constituent of chitosan for being 1%~2% with mass ratio；The cleaning agent has mass ratio in one of the embodiments, For 1.6%~2% constituent of chitosan；In one of the embodiments, the cleaning agent have mass ratio be 1%, 1.5%, 1.6%, 1.8%, 2%, 3%, 4% or 5% constituent of chitosan；And/or it is described in one of the embodiments, It is 5%~10% constituent of chitosan that film forming agent, which has mass ratio,.The film forming agent has matter in one of the embodiments, The constituent of chitosan that amount ratio is 2%~5%.It is 2.4% that the film forming agent, which has mass ratio, in one of the embodiments, ~3.8% constituent of chitosan.In one of the embodiments, the film forming agent have mass ratio be 2%, 2.4%, 2.5%, 3%, 3.8%, 5%, 6%, 7%, 8%, 9%, 10%, 11% or 12% constituent of chitosan.A reality wherein It applies in example, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning agent and it is described at Film all has constituent of chitosan；Wherein, it is 2%~4% constituent of chitosan that the cleaning agent, which has mass ratio,；It is described at It is 5%~10% constituent of chitosan that film, which has mass ratio,.The cleaning agent has quality in one of the embodiments, The constituent of chitosan that ratio is 1.6%~2%, it is 2%~5% constituent of chitosan that the film forming agent, which has mass ratio,.? In one embodiment, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning Agent and the film forming agent all have constituent of chitosan；Wherein, it is 2% constituent of chitosan that the cleaning agent, which has mass ratio,； It is 6% constituent of chitosan that the film forming agent, which has mass ratio,.The cleaning agent has quality in one of the embodiments, The constituent of chitosan that ratio is 4%；It is 8% constituent of chitosan that the film forming agent, which has mass ratio,.An implementation wherein In example, it is 3% constituent of chitosan that the cleaning agent, which has mass ratio,；It is 7% shell that the film forming agent, which has mass ratio, Chitosan component.It is 3.5% constituent of chitosan that the cleaning agent, which has mass ratio, in one of the embodiments,；It is described at It is 9% constituent of chitosan that film, which has mass ratio,.The cleaning agent is with mass ratio in one of the embodiments, 2.5% constituent of chitosan；It is 10% constituent of chitosan that the film forming agent, which has mass ratio,.One embodiment wherein In, it is 4% constituent of chitosan that the cleaning agent, which has mass ratio,；The film forming agent has the shell that mass ratio is 5% poly- Sugared ingredient.Remaining embodiment and so on.Further, in each embodiment, the constituent of chitosan content of the film forming agent is higher than The constituent of chitosan of the cleaning agent.Further, in each embodiment, example in mass ratio, the constituent of chitosan of the film forming agent It is 2 times of the constituent of chitosan of the cleaning agent.

The cleaning agent is the physiological saline with constituent of chitosan in one of the embodiments,.Physiological saline refers to The of substantially equal sodium chloride solution of the osmotic pressure of Physiology Experiment or clinically common osmotic pressure and animal or human plasma, is used 0.85~0.9% when mammal and human body, osmotic pressure is approximate with blood of human body, the content of sodium also with blood plasma phase Closely, but the content of chlorine is apparently higher than the content of chlorine in blood plasma, can external application, as applied when clean wound or dressing.The cleaning It is 0.5%~5% constituent of chitosan that agent, which has mass ratio, i.e., it is 0.5%~5% shell that physiological saline, which has mass ratio, Chitosan component, remaining embodiment and so on.The cleaning agent further includes suitable phosphoric acid hydrogen two in one of the embodiments, Sodium and/or sodium dihydrogen phosphate.Such design is made so that the cleaning agent has preferably to rinse, clean, moisturize and sterilize etc. With.

It is 0.01%~0.05% that the cleaning agent, which is the mass ratio with constituent of chitosan, in one of the embodiments, Benza.Benzalkonium chloride (BenzaLkonium chLoride) chemical name is chlorodimethyl benzyl hydrocarbon ammonium, is belonged to It is wide-spectrum bactericide in cation quaternary ammonium salt type surfactant, bacterial cytoplasm membrane permeability can be changed, makes outside thallus endochylema substance It seeps, it is hindered to be metabolized and play killing effect.It is stronger to gram-positive bacteria effect, to Pseudomonas aeruginosa, acid-fast bacilli and cell bud Born of the same parents are invalid, can be combined rapidly with protein, and in the presence of meeting blood, cotton, cellulose and organic matter, effect is significantly reduced；Usually 0.1% or less concentration is suitable for pre-surgical skin disinfection, mucous membrane and wound disinfection to no skin irritation.A reality wherein Apply in example, the cleaning agent be the mass ratio with constituent of chitosan be 0.01%, 0.02%, 0.03%, 0.04% or 0.05% Benza.

The cleaning agent is the second that the volume ratio with constituent of chitosan is 70%~75% in one of the embodiments, Alcoholic solution.70%~75% ethanol solution is commonly referred to as alcohol, and the polarity of hydroxyl is but also many ionic compounds in ethyl alcohol It dissolves in ethanol solution.In one of the embodiments, the cleaning agent be the volume ratio with constituent of chitosan be 70%, 71%, 72%, 73%, 74% or 75% ethanol solution.Such cleaning agent volatility is preferable, and residual degree is low, especially suitable Cooperation is that cleaning agent uses.

The cleaning agent is the iodine that the mass ratio with constituent of chitosan is 0.5%~1% in one of the embodiments, Lie prostrate solution.Iodophor is that the indefinite form conjugate of iodine and polyvinylpyrrolidone (Povidone) is also known as complex compound, is had wide Bactericidal effect is composed, bacterial propagule, fungi, protozoon and fractionated viral can be killed, therefore be medically used as disinfection sanitizer, it can For the disinfection of skin, mucous membrane, scald, treatment trichomonas vaginitis, colpomycosis, skin fungus infection can also be handled Deng, it may also be used for the disinfection of operation consent and other skins, various injection site skin degermings, instrument soaking disinfection and vagina hand Preoperative disinfection etc..Iodophor and the tincture of iodine are all disinfectants, and efficacy component is iodine, but the tincture of iodine is using ethanol solution as solvent, iodine Volt is using water as solvent, and the two effect is identical, and Iodophor is also wider than the purposes of the tincture of iodine in some sense.Since Iodophor is It is made using water of solvent, therefore there is no irritation to skin, mucous membrane, wound, this is its place more outstanding than the tincture of iodine.Now generally use In muscle, intravenous injection, external application, perform the operation skin disinfectant.The cleaning agent is poly- with shell in one of the embodiments, The iodophor solution that the mass ratio of sugared ingredient is 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1%.Further, wherein In one embodiment, it is wide that the cleaning agent, which is the Betagen Solution that the mass ratio with constituent of chitosan is 3%~5%, The powerful disinfectant of spectrum has stronger killing effect to virus, bacterium, fungi and mycotic spore, and to skin irritatin Property it is small, toxicity is low, persistent, and use is safe and simple, substantially nonirritant to organizing, and sterilizes for skin and mucous membrane, such as hand Preoperative cleaning, operative site and wound disinfection.

In order to promote bactericidal anti-inflammatory effect, further, the cleaning agent and/or described in one of the embodiments, Film forming agent includes or further includes the silvery agent that mass ratio is 0.01%~0.1%, i.e., the described cleaning agent includes or further includes matter Amount ratio be 0.01%~0.1% silvery agent, and/or, the film forming agent include or further include mass ratio be 0.01%~ 0.1% silvery agent.The silvery agent includes nano silver in one of the embodiments,.It is described in one of the embodiments, Silvery agent includes silver ion alginates.In experiments it is found that silver ion alginates cooperation constituent of chitosan has fabulous sterilization Anti-inflammatory synergistic effect, can effectively kill the miscellaneous bacteria of wound surface, wound is made to avoid the infection of the bacterial strains such as bacterium, fungi, gemma.

Film forming agent is also known as coalescing agent, is capable of forming the polymer of continuous film；In one of the embodiments, it is described at Film is Watery film-fomer.The film forming agent is selected from albumen film forming agent in one of the embodiments, acrylic resin forms a film One of agent, polyethylene kind copolymer, hydrocarbon type copolymer, organosilicon polymer or Si acrylate are a variety of.Wherein one In a embodiment, the film forming agent is complexing agent comprising a variety of film forming agents are used in mixed way.Institute in one of the embodiments, Stating film forming agent includes albumen film forming agent, acrylic resin film forming agent, polyethylene kind copolymer, hydrocarbon type copolymer, polymerizable organosilicon At least two in object and Si acrylate.The film forming agent includes that sodium alginate and gelatin are molten in one of the embodiments, Liquid, chitosan is miscible or is suspended in sodium alginate and gelatin solution, it will be understood that in the cleaning agent and the film forming agent With moisture appropriate.The film forming agent includes the glycerine that mass ratio is 1%~12% in one of the embodiments,； The film forming agent includes the polyethylene glycol that mass ratio is 1%~8% in one of the embodiments,；An implementation wherein In example, the film forming agent includes the hyaluronic acid that mass ratio is 0.1%~0.5%；In one of the embodiments, it is described at Film includes basic fibroblast growth factor (the basic FibrobLast that mass ratio is 0.01%~0.05% Growth Factor, bFGF) or epidermal growth factor (EpidermaL Growth Factor, EGF)；An implementation wherein In example, the film forming agent includes the sodium alginate that mass ratio is 8%~20%；The film forming in one of the embodiments, Agent includes the collagen or human-like collagen that mass ratio is 0.2%~0.8%；In each embodiment, tradition also can be used The related film forming agent of formula.Further, the film forming agent includes or further includes that mass ratio is in one of the embodiments, Hyaluronic acid that 1%~12% glycerine, mass ratio are 0.1%~0.5%, mass ratio are 0.01%~0.05% The sodium alginate that basic fibroblast growth factor and mass ratio are 8%~20%；It is described in one of the embodiments, Film forming agent include or further include mass ratio be 4% glycerine, mass ratio be 0.2% hyaluronic acid, mass ratio be The sodium alginate that 0.04% basic fibroblast growth factor and mass ratio is 9%；Institute in one of the embodiments, State film forming agent include mass ratio be 10% constituent of chitosan, mass ratio be 4% glycerine, mass ratio 0.2% Hyaluronic acid, mass ratio be 0.04% basic fibroblast growth factor and mass ratio be 9% sodium alginate, Surplus is for example medical pure water of pure water；Remaining embodiment and so on.

To promote Wound healing, further, the film forming agent includes or further includes quality in one of the embodiments, The brown alga oligose that ratio is 1%~5%, brown alga oligose cooperate constituent of chitosan in film forming agent, are conducive to induce and improve thin Intracellular growth activity, promotes fibroblastic transfer and increment, improves local microcirculation, creates suitable cell growing environment, To wound healing.In one of the embodiments, the film forming agent include or further include mass ratio be 1%, 2%, 3%, 4% or 5% brown alga oligose.Further, example, the film forming agent include in mass ratio in one of the embodiments, 2%~12% constituent of chitosan, 1%~12% glycerine, 0.1%~0.5% hyaluronic acid, 0.01%~0.05% Basic fibroblast growth factor, 8%~20% sodium alginate and 1%~5% brown alga oligose, surplus be it is pure Water；Example in mass ratio in one of the embodiments, the film forming agent include 4%~10% constituent of chitosan, 2%~8% Glycerine, 0.2%~0.4% hyaluronic acid, 0.02%~0.04% basic fibroblast growth factor, 10%~ 12% sodium alginate and 2%~4% brown alga oligose, surplus is pure water；In one of the embodiments, in mass ratio Example, the film forming agent include 6% constituent of chitosan, 5% glycerine, 0.3% hyaluronic acid, 0.03% alkalinity into fibre Tieing up Porcine HGF, 11% sodium alginate and 3% brown alga oligose, surplus is pure water；Remaining embodiment and so on.

For promoted wound blood coagulation haemostatic effect, further, in one of the embodiments, the film forming agent include or It further include the hemostasis auxiliary material that mass ratio is 0.1%~1%.The film forming agent includes or also wraps in one of the embodiments, Include the hemostasis auxiliary material that mass ratio is 0.1%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8% or 1%.An implementation wherein In example, the hemostasis auxiliary material includes coagulation factor；Coagulation factor is the various protein components for participating in Blood Coagulation Process, life Reason effect is: is activated together with platelet adhesion in angiorrbagia and mends the leak on plug blood vessel.This process quilt Referred to as blood coagulation.Entire coagulation process can generally be divided into two stages, the activation of factor and the fibrinous shape of gel At.It is (1~2): 1 fibrinogen and fibrin ferment that the coagulation factor, which includes mass ratio, in one of the embodiments, It is former；In one of the embodiments, the coagulation factor include mass ratio be (1~2): 1:(1~2) fibrinogen, Factor and the calcium factor.The hemostasis auxiliary material further includes Fibrin Glue in one of the embodiments,；A reality wherein It applies in example, the hemostasis auxiliary material further includes micropore polysaccharide styptic powder；The hemostasis auxiliary material also wraps in one of the embodiments, Include fibrin ferment.In one of the embodiments, the hemostasis auxiliary material include mass ratio be (1~2): 1 Fibrin Glue with Coagulation factor.In one of the embodiments, it is described hemostasis auxiliary material include mass ratio be (1~2): 1:(1~2) fiber egg White glue, coagulation factor and micropore polysaccharide styptic powder.The hemostasis auxiliary material includes that mass ratio is in one of the embodiments, (1~2): 1:1:(1~2) Fibrin Glue, fibrin ferment particle, coagulation factor and micropore polysaccharide styptic powder.It is such to set On the one hand hemostasis auxiliary material is dexterously designed into film forming agent by meter, in first time contact blood source to generate blood coagulation anastalsis, On the other hand be conducive to trigger intrinsic coagulation system acute activation by hemostasis auxiliary material and promote the generation of fibrin ferment, then exist Under the action of fibrin ferment, the accelerated hydrolysis of fibrinogen reinforces to form insoluble fibrin through fibrin stabilizing factor Polymer is advantageously implemented wound healing to realize hemostasis and prevent the effect of tissue adhesion on this basis.

For promoted wound blood coagulation haemostatic effect, further, in one of the embodiments, the film forming agent include or It further include the amino acid that mass ratio is 0.1%~0.4%.The film forming agent includes or also wraps in one of the embodiments, Include the amino acid that mass ratio is 0.1%, 0.2%, 0.3% or 0.4%.The amino acid packet in one of the embodiments, Include at least one of threonine, valine and tryptophan；The amino acid is threonine, figured silk fabrics in one of the embodiments, Propylhomoserin or tryptophan；The amino acid includes threonine, the valine that mass ratio is 2:1:1 in one of the embodiments, With tryptophan.The amino acid includes phosphatidylserine in one of the embodiments,；Institute in one of the embodiments, Stating amino acid includes threonine, valine, tryptophan and the phosphatidylserine that mass ratio is 2:1:1:1.

It is appreciated that the constituent of chitosan is the ingredient with chitosan；The shell is poly- in one of the embodiments, Sugared ingredient is selected from chitosan, organic selenium molecular chitosan derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginic acid One of salt or carboxymethyl chitosan are a variety of.The constituent of chitosan is or gathers including shell in one of the embodiments, Sugar, i.e., the described constituent of chitosan is chitosan or the constituent of chitosan includes chitosan；Further, an implementation wherein In example, the N- deacetylation of the chitosan is greater than 80%.Further, the chitosan in one of the embodiments, N- deacetylation is greater than 85%.The constituent of chitosan is chitosan, organic selenium molecular chitosan in one of the embodiments, Derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginates or carboxymethyl chitosan.Further, wherein one In a embodiment, the constituent of chitosan includes the chitosan and chitosan derivatives that mass ratio is 5:1~15:1；Wherein, The chitosan derivatives include organic selenium molecular chitosan derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan algae At least one of hydrochlorate and carboxymethyl chitosan.The constituent of chitosan includes mass ratio in one of the embodiments, For the chitosan and chitosan derivatives of 8:1~12:1.The constituent of chitosan includes mass ratio in one of the embodiments, Example is the chitosan and chitosan derivatives of 8:1,9:1,10:1,11:1 or 12:1.Further, one embodiment wherein In, the constituent of chitosan includes the chitosan and chitosan derivatives that mass ratio is 5:1~15:1；An implementation wherein In example, the constituent of chitosan includes the chitosan and chitosan derivatives that mass ratio is 8:1~12:1.A reality wherein It applies in example, the constituent of chitosan includes that the chitosan that mass ratio is 8:1,9:1,10:1,11:1 or 12:1 and chitosan spread out Biology.Further, in one of the embodiments, the chitosan derivatives include organic selenium molecular chitosan derivative, At least two in chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginates and carboxymethyl chitosan.A reality wherein It applies in example, the chitosan derivatives include the chitosan quaternary ammonium salt and chitosan hydrochloride that mass ratio is 1:1~1:4；Shell Glycan quaternary ammonium salt and chitosan hydrochloride all have water speed dissolved cation sterilization idiocratic, are the chemically modified modifications of chitosan and make The chitosan derivatives obtained.In one of the embodiments, the chitosan derivatives include 1:1:2 chitosan quaternary ammonium salt, Chitosan hydrochloride and chitosan alginates；Chitosan alginates, that is, chitosan alginate.Institute in one of the embodiments, Stating chitosan derivatives includes the chitosan quaternary ammonium salt and carboxymethyl chitosan that mass ratio is 1:2；Carboxymethyl chitosan is also Chitosan derivatives prepared by the chemically modified modification of chitosan, property are stablized, and antibiotic property is strong.Further, wherein one In a embodiment, organic selenium molecular chitosan derivative is using chitosan and adjacent first seleno benzoic acid p-nitrophenyl phenolic ester, 2- benzene Base -1,2- benzisoxa selenazoles -3- (2H) -one, -3 (2H) ketone of 2- (4 benzoic acid carbomethoxy) -1,2- benzisoxa selenazoles and/or selenium It reacts to obtain for oxalic acid, specific reaction ratio is designed and adjusted according to demand.In this way, multiple or even a variety of organic seleniums Molecule passes through multiple NH on chitosan₂Group is connected respectively on polymer chitosan, has certain anti peroxidation of lipid Activity and anti-tumor activity, either using in vitro or in vivo all with good antibacterial film-formation result, additionally it is possible to be applicable in In tumor operation；Further, example, the film forming agent include 2%~12% in mass ratio in one of the embodiments, Organic selenium molecular chitosan derivative, 1%~12% glycerine, 0.1%~0.5% hyaluronic acid, 0.01%~ 0.05% basic fibroblast growth factor, 8%~20% sodium alginate and 1%~5% brown alga oligose, surplus is Pure water, further, example, the film forming agent include 2%~12% chitosan in mass ratio in one of the embodiments, Ingredient, 1%~12% glycerine, 0.1%~0.5% hyaluronic acid, 0.01%~0.05% basic fibroblast Growth factor, 8%~20% sodium alginate and 1%~5% brown alga oligose, surplus are pure water, the constituent of chitosan The chitosan and organic selenium molecular chitosan derivative for being 8:1 including mass ratio, wherein organic selenium molecular chitosan derivative Using chitosan and adjacent first seleno benzoic acid p-nitrophenyl phenolic ester, 2- phenyl -1,2- benzisoxa selenazoles -3- (2H) -one, 2- (4- Methyl benzoate base) -1,2- benzisoxa selenazoles -3 (2H) ketone and seleno-diacetic acid react to obtain；Such design, including it is organic Selenium molecular chitosan derivative cooperates the film forming agent of brown alga oligose, has preferable facilitation for immune system and resists Oxidation effectiveness helps to inhibit tumor cell proliferation.

The cleaning agent and the film forming agent have different constituent of chitosan in one of the embodiments,.Further The constituent of chitosan on ground, the cleaning agent is or including chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan At least one of alginates and carboxymethyl chitosan.Further, the constituent of chitosan of the film forming agent be or including At least one of chitosan and organic selenium molecular chitosan derivative.The institute of the cleaning agent in one of the embodiments, Stating constituent of chitosan is chitosan；The constituent of chitosan of the film forming agent includes the chitosan season that mass ratio is 1:1:2 Ammonium salt, chitosan hydrochloride and chitosan alginates.The constituent of chitosan of the cleaning agent in one of the embodiments, For chitosan；The constituent of chitosan of the film forming agent includes the chitosan quaternary ammonium salt and chitosan salt that mass ratio is 1:1 Hydrochlorate.Remaining embodiment and so on.As previously mentioned, cleaning agent and film forming agent are applied in the chitosan liquid of each embodiment of the application Positioning in material is different, and cleaning agent pays attention to cleaning effect, more demanding for mobility, and film forming agent is paid attention to form a film Isolating and protecting effect, while wound being made to realize moistening effect, further also promote Wound healing under the premise of to Wound protection, In use, the cleaning agent of the chitosan liquid dressing is rinsed the surface of a wound, then sprays the chitosan liquid The film forming agent of body dressing covers wound.Therefore give different proportions according to different product orientation to be arranged, be conducive to Flexible product line is realized under the premise of save the cost；In specific application, cleaning agent carry out cleaning bactericidal antiphlogistic with Under the double action of film forming agent bactericidal antiphlogistic, the closed environment quickly formed by film forming agent can effectively retain wound Diffusate, reduces exudation and adhesion, and moist environment needed for providing quick healing of cut accelerates epidermal cell migration velocity, thorn Swash cell Proliferation and promote release Porcine HGF, and inhibits the growth of bacterium in wound and promote fibroblastic life It is long, thus promote cytothesis, it is further provided good zymetology debridement environment, to promote fibrin and necrotic tissue Dissolution, and then realize acceleration wound healing.

In the embodiment that one is applied, there is the chitosan liquid dressing product of applicant the cleaning agent of subregion setting to hold Chamber and film forming agent accommodating cavity are set, stores from same liquid storage bottle and sprays respectively respectively, use can also be supplemented respectively, either occupied Family is spare or medical use is all very convenient.That is, it is divided into mutual disconnected two accommodating cavities in a bottle, one For cleaning agent accommodating cavity, for storing cleaning agent, another is film forming agent accommodating cavity, for storing film forming agent.A reality wherein Apply in example, the chitosan liquid dressing further includes liquid storage bottle, the liquid storage bottle be equipped with mutual disconnected cleaning agent accommodating cavity with Film forming agent accommodating cavity, for the cleaning agent accommodating cavity for accommodating the cleaning agent, the film forming agent accommodating cavity is described for accommodating Film forming agent；Further, the liquid storage bottle is equipped with the cleaning agent for being connected to the cleaning agent accommodating cavity in one of the embodiments, Spray head and the film forming agent spray head for being connected to the film forming agent accommodating cavity；The cleaning agent spray head is used to spray by pressing mode described The cleaning agent of cleaning agent accommodating cavity, the film forming agent spray head are used to spray the film forming of the film forming agent accommodating cavity by pressing mode Agent；Further, the liquid storage bottle is equipped with cleaning agent accommodating cavity valve, film forming agent accommodating cavity valve in one of the embodiments, Door and pressing spray head, the pressing spray head are connected to the cleaning agent accommodating cavity, and institute by the cleaning agent accommodating cavity valve It states pressing spray head and the film forming agent accommodating cavity is connected to by the film forming agent accommodating cavity valve；Such design simplifies spray head, While saving production cost, pass through the switch and film forming agent accommodating cavity valve of control cleaning agent accommodating cavity valve with can be convenient The switch of door exports cleaning agent or film forming agent to control the pressing spray head, and can export cleaning agent and film forming simultaneously when necessary The mixed liquor of agent.Further, the cleaning agent accommodating cavity valve and the film forming agent accommodating cavity in one of the embodiments, Valve is wholely set to form a two-way valve, and the input duct of the pressing spray head and the two-way valve are rotatablely connected, described double It is used to make the input duct that the cleaning agent accommodating cavity be connected when turning to the first predeterminated position to valve and turns to second Make the input duct that the film forming agent accommodating cavity be connected when predeterminated position.Further, described in one of the embodiments, Cleaning agent accommodating cavity valve and the film forming agent accommodating cavity valve are wholely set to form a two-way valve, the pressing spray head into Liquid pipe road and the two-way valve are rotatablely connected, and the two-way valve is for being connected the input duct when turning to a side position The cleaning agent accommodating cavity makes the input duct and the film forming agent accommodating cavity and the cleaning agent when turning to middle position Accommodating cavity is in nonconducting state and makes the input duct that the film forming agent accommodating cavity be connected when turning to another side position. On the one hand such design is conducive to conversion using the cleaning agent and the film forming agent, is on the other hand conducive to when stored The isolation degree of the cleaning agent Yu the film forming agent is kept, to improve the use validity period of product.Further, wherein In one embodiment, the liquid storage bottle is in the cleaning agent accommodating cavity or its wall portion and the film forming agent accommodating cavity or its wall part Not She You injection hole and its closure portion, for the closure portion for closing the injection hole, the injection hole is described clear for injecting Lotion or the film forming agent, i.e., the injection hole of the described cleaning agent accommodating cavity is for injecting the cleaning agent, the film forming agent accommodating The injection hole of chamber is for injecting the film forming agent；Such design can reuse the liquid storage bottle and cleaning agent therein Accommodating cavity and film forming agent accommodating cavity are particularly suitable for the biggish occasion of the dosages such as hospital and use.

In order to promote the blood coagulation haemostatic effect of film forming agent, further, the film forming agent spray in one of the embodiments, Head or the pressing spray head have multiple spray orifices, in one of the embodiments, the film forming agent spray head or the pressing spray head With multiple spray orifices and the multiple spray orifice is distributed in more than center and in a manner of periphery is few；Further, an implementation wherein In example, the multiple spray orifice forms multiple annular concentrics, and the interannular of each annular concentric of central area is away from less than neighboring area Each annular concentric interannular away from；Further, in one of the embodiments, from the center to periphery, the ring of each annular concentric Spacing forms ascending series, also referred to as the first ascending series.Further, in one of the embodiments, from the center to week Side, the interannular of each annular concentric is away from formation equal difference ascending series, also referred to as the first equal difference ascending series.Further, at it In middle one embodiment, the spacing of the adjacent orifices of each annular concentric of central area is less than each annular concentric of neighboring area The spacing of adjacent orifices.Further, in one of the embodiments, from the center to periphery, the adjacent orifices of each annular concentric Spacing formed ascending series, also referred to as the second ascending series.Further, in one of the embodiments, from the center to The spacing on periphery, the adjacent orifices of each annular concentric forms equal difference ascending series, also referred to as the second equal difference ascending series.First Equal difference ascending series and the difference of the second equal difference ascending series can identical or different settings.Such design, forms center The few spray orifice distribution in more peripheries, so that the film forming agent that central area sprays is more, and then can artificially control film forming agent Main ejection distribution at key position, thereby realizes film forming agent and mainly concentrates and be sprayed at serious wound, is thus promoted Blood coagulation haemostatic effect of the film forming agent at wound key position.And/or in order to preferably promote the blood coagulation of film forming agent hemostasis effect Fruit, further, the aperture of the multiple spray orifice is distributed in such a way that center is big and periphery is small in one of the embodiments,； Further, in one of the embodiments, from the center to periphery, the aperture of each spray orifice forms ascending series, can also claim For third ascending series.Further, in one of the embodiments, from the center to periphery, the aperture of each spray orifice is formed Equal difference ascending series, also referred to as third equal difference ascending series.Such design forms the small spray orifice in the big periphery in center point Cloth, so that the film forming agent that central area sprays is more, and then can artificially control the main ejection distribution of film forming agent, this Sample is achieved that film forming agent is mainly concentrated and is sprayed at serious wound, thus improves blood coagulation of the film forming agent at wound key position Haemostatic effect.

In order to promote the antibacterial and anti-inflammatory effects of the chitosan liquid dressing, further, in one of the embodiments, The chitosan liquid dressing further includes the suspension of liquid, and the liquid storage bottle is additionally provided with suspension accommodating cavity, the suspension Accommodating cavity is for accommodating the suspension, the suspension accommodating cavity and the cleaning agent accommodating cavity and the film forming agent accommodating cavity It is not mutually connected to setting, i.e., the described liquid storage bottle is equipped with mutual disconnected suspension accommodating cavity, cleaning agent accommodating cavity and film forming agent and accommodates Chamber.Further, the liquid storage bottle is equipped with the suspension spray for being connected to the suspension accommodating cavity in one of the embodiments, Head, the suspension spray head are used to spray the suspension of the suspension accommodating cavity by pressing mode.Further, wherein In one embodiment, the liquid storage bottle is equipped with suspension accommodating cavity valve, cleaning agent accommodating cavity valve, film forming agent accommodating cavity valve With pressing spray head, the pressing spray head is connected to the cleaning agent accommodating cavity, the pressing by the cleaning agent accommodating cavity valve Spray head is connected to the film forming agent accommodating cavity by the film forming agent accommodating cavity valve, and the pressing spray head passes through the suspension Agent accommodating cavity valve is connected to the suspension accommodating cavity.Further, the suspension accommodating cavity in one of the embodiments, Valve, the cleaning agent accommodating cavity valve and the film forming agent accommodating cavity valve are wholely set to form a two-way valve, described to press The input duct and the two-way valve for pressing spray head are rotatablely connected, and the pressing spray head is for passing through the input duct and institute State two-way valve select the gating suspension accommodating cavity valve, the cleaning agent accommodating cavity valve and the film forming agent accommodating cavity or Person and the suspension accommodating cavity, the film forming agent accommodating cavity and the cleaning agent accommodating cavity are in nonconducting state.It is such On the one hand design is conducive to conversion using the suspension, the cleaning agent and the film forming agent, on the other hand has when stored Conducive to the isolation degree of the cleaning agent and the film forming agent is kept, to improve the use validity period of product.Further, exist In one embodiment, the liquid storage bottle is also equipped with injection hole and its closure portion in the suspension accommodating cavity or its wall portion, The closure portion is for closing the injection hole, and the injection hole of the suspension accommodating cavity is for injecting the suspension；In this way Design, the liquid storage bottle and suspension accommodating cavity therein can be reused, be particularly suitable for the biggish field of dosages such as hospital It closes and uses.The example of one application is when in use, first to carry out cleaning wound using cleaning agent, then sprayed and created with suspension Mouthful, then wound is closed with film forming agent, thus appropriate suspension is closed in wound.The example of another application is to use When, two-way valve is first rotated, makes it from equal with the suspension accommodating cavity, the film forming agent accommodating cavity and the cleaning agent accommodating cavity The connection cleaning agent accommodating cavity is gone in nonconducting state, presses the pressing spray head then to spray cleaning agent cleaning wound Mouthful, then two-way valve is rotated, so that it is gone to the connection suspension accommodating cavity, it is appropriate mixed to spray then to press the pressing spray head In suspension to wound, two-way valve is finally rotated, it is made to go to the connection film forming agent accommodating cavity, presses the pressing spray head to spray Wound is closed on appropriate film forming agent to wound out.

Further, it is that 1%~10% sustained release disappears that the suspension, which has mass ratio, in one of the embodiments, Scorching body；Further, the suspension is that the sustained release for being 1%~10% with mass ratio disappears in one of the embodiments, The physiological saline of scorching body；Remaining embodiment and so on.Further, the suspension is tool in one of the embodiments, There is the Benza that the mass ratio of sustained release anti-inflammatory body is 0.01%~0.05%.Further, one embodiment wherein In, the suspension is the ethanol solution that the volume ratio with sustained release anti-inflammatory body is 70%~75%.Further, wherein one In a embodiment, the suspension is cleaning agent described in any of the above-described embodiment with sustained release anti-inflammatory body.Further, at it In middle one embodiment, the suspension is film forming agent described in any of the above-described embodiment with sustained release anti-inflammatory body, or will be upper It states the constituent of chitosan in film forming agent described in any embodiment and replaces with the sustained release anti-inflammatory body.Further, each to implement In example, the sustained release anti-inflammatory body is the anti-inflammatory particle with wrapping layer.Such design, it is micro- using the anti-inflammatory with wrapping layer The sustained release anti-inflammatory body of grain enables above-mentioned chitosan liquid dressing to have long-acting sustained release antiinflammation in use, further Slow-release time can be controlled by the ingehious design to wrapping layer, to play longer sustained release antiinflammation, have and pass The unrivaled anti-inflammatory effects of system technology.Further, in one of the embodiments, each sustained release anti-inflammatory body be divided into it is N number of Sustained release anti-inflammatory body group, the different setting of the thickness of N number of wrapping layer for being sustained anti-inflammatory body group and formation ascending series, the also referred to as the 4th Ascending series；N is the natural number greatly with 1；Further, adjacent in the 4th ascending series in one of the embodiments, The thickness difference of two sustained release anti-inflammatory body groups is the 1/N of the estimated cure time of wound；Further, one embodiment wherein In, the thickness of the wrapping layer of N number of sustained release anti-inflammatory body group is different to be arranged and forms equal difference ascending series, and also referred to as the 4th equal difference is passed Increase ordered series of numbers.Such design, be sustained anti-inflammatory body in anti-inflammatory particle release process come across for a long time the chitosan liquid apply The degradation absorption process of material or even reach the chitosan liquid dressing degradation absorption process it is final, thus play compared with Long sustained release antiinflammation, on the one hand advantageously forms releasing the time for difference, is on the other hand conducive to control anti-inflammatory particle Start to release the time, above-mentioned chitosan liquid dressing is set during being degraded and absorbed according to the ingenious of wrapping layer Meter to play longer sustained release antiinflammation, and then can be controlled in chitosan liquid dressing to control slow-release time It is absorbed in overall process or part stage and is sustained anti-inflammatory particle on demand, therefore there is the unrivaled anti-inflammatory effect of traditional technology Fruit.Each sustained release anti-inflammatory body is divided at least two sustained release anti-inflammatory body groups, and each sustained release anti-inflammatory body group in one of the embodiments, Wrapping layer the different setting of thickness.

The wrapping layer includes chitosan or alginate fibre in one of the embodiments,.In one of the embodiments, The wrapping layer includes chitosan and alginate fibre.Alginate fibre is one kind of staple fibre, refers to some brown algaes from ocean The alginic acid extracted in class plant is fiber made from raw material；Alginate fibre is using extracted substance in natural seaweed Spinning is process, and since raw material comes from natural seaweed, alginate fibre has good biocompatibility and degradable suction Property received and other effects.Alginate fibre is obtained for example, being added to grind finely ground marine algae powder and reeled off raw silk from cocoons in spinning solution.This A little marine algae powders mostly come from brown algae, red algae, green alga and blue algae.Alginate fibre also has absorbability, it can be absorbed 20 The liquid of times oneself volume, it is possible to which reducing wound, microorganism evil is raw and its issuable peculiar smell of institute, therefore especially Suitable for hemostasis and as body absorption materials'use.The wrapping layer includes mass ratio in one of the embodiments, For the chitosan and alginate fibre of 1:1~1:4.Further, the wrapping layer includes mass ratio in one of the embodiments, Example is the chitosan and alginate fibre of 1:1,1:2,1:3 or 1:4.In this way, using chitosan as the wrapping layer part or entirely Portion can use the characteristics of chitosan itself inhibits bacterial activity, also function to a part of antibacterial and anti-inflammation functions.

The anti-inflammatory particle includes anti-inflammation drugs in one of the embodiments, described in one of the embodiments, to disappear Scorching particle includes sulfa drugs, i.e., the described anti-inflammation drugs include sulfa drugs；Sulfa drugs is broad spectrum antimicrobial agent, to leather Lan Shi positive bacteria and Gram-negative bacteria all have good antibacterial activity, and alternative inhibits micrococcus scarlatinae, pneumonia chain Coccus, haemophilus influenzae, escherichia coli, proteus mirabilis, chlamydia trachomatis, lymphogranuloma venereum Chlamydia Deng and actinomyces, lung sac worm and slave block Pseudomonas etc..Sulfa drugs can penetrate into extensively body tissue and liquor pleurae, peritoneal fluid, In the various extracellular fluids such as synovial fluid, aqueous humor, saliva, sweat, urine, bile, cerebrospinal fluid can be entered through blood-brain barrier, also can Into milk and pass through placental barrier.And/or the anti-inflammatory particle includes quinolone drugs in one of the embodiments, The i.e. described anti-inflammation drugs include quinolone drugs；Quinolone drugs is also known as pyridonecarboxylic acids or pyridine Mek-Tol Unit, is manually to close At the basic structure of quinolone containing 4- antimicrobial.Quinolones, for target, interferes DNA with the DNA (DNA) of bacterium Gyrase further results in the irreversible lesion of DNA of bacteria, reaches antibacterial effect；Object has sterilization to make a variety of gram-negative bacterias With being widely used in disease of the genitourinary system, gastrointestinal disease and respiratory tract, the gram-negative bacterial infection of skin histology is controlled It treats.Quinolone drugs is Enrofloxacin in one of the embodiments, have has a broad antifungal spectrum, sterilizing power are strong, effect is rapid, It is widely distributed in vivo and between other antibiotic without cross resistance the features such as, and/or, institute in one of the embodiments, Stating anti-inflammatory particle includes povidone iodine, i.e., the described anti-inflammation drugs include povidone iodine；Povidone iodine (Povidone iodine) is Elemental iodine and polymer support loose compound made of combining, povidone play carrier and dissolution assistant effect.It is strong for wide spectrum Power disinfection sanitizer has stronger killing effect to virus, bacterium, fungi and mycotic spore.This product is small to skin irritation, Toxicity is low, persistent.Using safe and simple.It is substantially nonirritant to organizing, it is sterilized for skin and mucous membrane, such as operation consent Cleaning, operative site and wound disinfection.And/or the anti-inflammatory particle includes phosphatidyl silk ammonia in one of the embodiments, Acid, i.e., the described anti-inflammation drugs include phosphatidylserine；Phosphatidylserine is also known as composite nerve acid.English name PhosphatidyLserine, abbreviation PS are extracted by crude soya bean oil expression residue.It is the active material of cell membrane, especially deposits It is in brain cell.Its function mainly improves nerve cell function, adjusts the conduction of nerve impulse, promotes brain memory function Can, blood-brain barrier can be run through since it is with very strong lipophilicity, after absorption and enters brain, play vascular smooth of releiving Myocyte increases the effect of brain blood supply, and application herein also helps activation injured surface factor.In each embodiment, It is lasting that the anti-inflammatory particle has under slow releasing function i.e. using particle made of the above-mentioned drug with antiinflammation, on the one hand On the other hand anti-inflammatory effects exist due to it in wrapping layer with particle, that is, solid form, shelf life of products, that is, chitosan liquid The storage period of body dressing, is long, and service life is protected.Further, the anti-inflammatory is micro- in one of the embodiments, Grain be it is powdered, can more effectively be absorbed in this way by tissue fluid.It is appreciated that in each embodiment, the use of the anti-inflammatory particle Amount and proportion are arranged according to product design.Further, wrapping layer and anti-inflammatory particle therein in one of the embodiments, Mass ratio be 10:1~120:1.Further, the anti-inflammatory particle includes mass ratio in one of the embodiments, For the sulfa drugs and phosphatidylserine of 9:1~16:1.Further, the anti-inflammatory is micro- in one of the embodiments, Grain includes the quinolone drugs and phosphatidylserine that mass ratio is 9:1~16:1.Further, an implementation wherein In example, the anti-inflammatory particle includes sulfa drugs, povidone iodine and the phosphatidylserine that mass ratio is 10:2:1.Into one Step ground, the anti-inflammatory particle includes the sulfa drugs and Du-6859a that mass ratio is 1:1 in one of the embodiments, Object.Further, in one of the embodiments, the anti-inflammatory particle include mass ratio be 12:10:2:1 sulfonamides Object, quinolone drugs, povidone iodine and phosphatidylserine.It is appreciated that anti-inflammatory particle can also include other anti-inflammatory drugs Object, the application have no additional limitation to this.

It provides some embodiments again below and carries out Experimental Comparison.

Embodiment 1, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning Agent and the film forming agent all have constituent of chitosan；Wherein, the cleaning agent have mass ratio be 0.5% chitosan at Point；It is 2% constituent of chitosan that the film forming agent, which has mass ratio, and the cleaning agent is the physiology salt with constituent of chitosan Water, the cleaning agent further include the silver ion alginates that mass ratio is 0.01%, and film forming agent example in mass ratio further includes 10% sodium alginate and 0.8% collagen.The constituent of chitosan of the cleaning agent and the film forming agent is chitosan.

Embodiment 2, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning Agent and the film forming agent all have constituent of chitosan；Wherein, it is 2% constituent of chitosan that the cleaning agent, which has mass ratio,； It is 4% constituent of chitosan that the film forming agent, which has mass ratio, and the cleaning agent is that the mass ratio with constituent of chitosan is 0.02% Benza, film forming agent example in mass ratio further include 0.1% hyaluronic acid, 0.05% alkalinity at Fibroblast growth factor and 5% glycerine.The constituent of chitosan of the cleaning agent is chitosan, and the shell of the film forming agent is poly- Sugared ingredient is chitosan.

Embodiment 3, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning Agent and the film forming agent all have constituent of chitosan；Wherein, it is 1% constituent of chitosan that the cleaning agent, which has mass ratio,； It is 10% constituent of chitosan that the film forming agent, which has mass ratio, and the cleaning agent is that the volume ratio with constituent of chitosan is 75% ethanol solution, film forming agent example in mass ratio further include 4% glycerine, 0.2% hyaluronic acid, 0.04% Basic fibroblast growth factor and 9% sodium alginate.The constituent of chitosan of the cleaning agent includes that mass ratio is 5:1 Chitosan and chitosan derivatives；Wherein, the chitosan derivatives include mass ratio be 1:2 chitosan quaternary ammonium salt with Chitosan hydrochloride, the constituent of chitosan of the film forming agent include the chitosan and chitosan derivatives that mass ratio is 6:1；Its In, the chitosan derivatives are chitosan alginates.

Embodiment 4, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning Agent and the film forming agent all have constituent of chitosan；Wherein, it is 5% constituent of chitosan that the cleaning agent, which has mass ratio,； It is 12% constituent of chitosan that the film forming agent, which has mass ratio, and the cleaning agent is that the mass ratio with constituent of chitosan is 0.5% iodophor solution；Film forming agent example in mass ratio further includes 5% glycerine, 0.3% hyaluronic acid, 0.03% Basic fibroblast growth factor, 11% sodium alginate and 3% brown alga oligose, surplus is pure water.The cleaning The constituent of chitosan of agent is chitosan, and the constituent of chitosan includes the chitosan and organic selenium molecule shell that mass ratio is 8:1 Polysaccharid derivative, wherein organic selenium molecular chitosan derivative using chitosan and adjacent first seleno benzoic acid p-nitrophenyl phenolic ester, 2- phenyl -1,2- benzisoxa selenazoles -3- (2H) -one, -3 (2H) ketone of 2- (4 benzoic acid carbomethoxy) -1,2- benzisoxa selenazoles and selenium It reacts to obtain for oxalic acid.

Reference examples 1: the commercially available domestic chitosan liquid dressing of certain money.

A kind of reference examples 2: chitosan liquid dressing comprising the cleaning agent of liquid；The cleaning agent has mass ratio For 2% constituent of chitosan；The cleaning agent is the Benza that the mass ratio with constituent of chitosan is 0.02%.It should Reference examples 2 are identical as the cleaning agent of embodiment 2, but film former-free.

A kind of reference examples 3: chitosan liquid dressing comprising the film forming agent of liquid；The film forming agent have chitosan at Point；It is 2% constituent of chitosan that the film forming agent, which has mass ratio, and film forming agent example in mass ratio further includes 10% sea Mosanom and 0.8% collagen.The reference examples 3 are identical as the film forming agent of embodiment 1, but without cleaning agent.

Sterilization experiment: bactericidal property (GB is carried out respectively to chitosan dressing prepared by embodiment 1 to 4, reference examples 1 to 3 15979-2002 appendix C), cytotoxicity (GB/T14233.2-2005 chapter 8), sensitization (GB/T16886.10-2005 Seven chapters), intradermal reaction (GB/T16886.10-2005), systemic acute toxi-city (GB/T 16886.11-2011 chapter 5) experiment, Testing result is as shown in table 1.

Table 1

The chitosan dressing sterilizing rate that the embodiment of the present invention 1 to 4 and reference examples 1 to 3 provide meets GB 90% or more 15979 evaluation criterion illustrates that chitosan dressing provided by the embodiment of the present invention 1 to 4 has bactericidal effect；And the present invention is real The chitosan dressing sterilizing rate of the offer of example 1 to 4 is applied 95% or more, it is bright to further illustrate that medical dressing provided by the invention has Aobvious biocidal efficacies.The embodiment of the present invention 1 to 4 is also embodied by no sensitization simultaneously, no cytotoxicity and general toxicity etc., I.e. chitosan dressing provided by the embodiment of the present invention 1 to 4 is harmless, has met the examination criteria of medical and sanitary products.

Also, when wound needs to clear up, the dosage of reference examples is the 2 to 7 of the film forming agent dosage of each embodiment of the application Times, it can be seen that the chitosan liquid dressing of the application can greatly reduce the dosage of film forming agent.

Embodiment 1 to 4 and reference examples 1 to 3 are carried out with film formation time and form test respectively, it is specific as follows: to take 28 SD (Sprague Dawley) rat, half male and half female, weight are 132 ± 12.4g, are randomly divided into 7 groups, every group 4 and female It is male fifty-fifty；The chitosan liquid dressing of Example 1 to 4 and reference examples 1 to 3, the corresponding embodiment of every group of SD rat or a pair As usual；1.2cm is outputed respectively at the skin of every SD rat²±0.2cm²Wound；The chitosan liquid dressing of embodiment 1 to 4 It is sequentially sprayed on respectively relatively by the cleaning agent dosage of 0.7mL every square centimeter and the film forming agent dosage of 0.3mL every square centimeter The trauma skin surface of the one group of SD rat answered carries out wound cleaning and film forming.Reference examples 1~3 are by 0.7mL's every square centimeter Cleaning dosage and 0.3mL every square centimeter film forming dosage are sequentially sprayed on the trauma skin table of corresponding one group of SD rat respectively Face carries out wound cleaning and film forming.Observe its film-forming time and form.The observation knot of film formation time detection and Film Morphology Fruit is as shown in table 2 below.

Table 2

By upper table 2 it is found that the chitosan liquid dressing of embodiment 1 to 4 and reference examples 1 and 3 all has preferable film forming, Membrane body is more smooth, and the film formation time of embodiment 3 and 4 is shorter.But the chitosan liquid dressing dosage of reference examples 1 and 3 More than the 2 times or more of the film forming agent dosage of the chitosan liquid dressing of embodiment 1 to 4.

The chitosan liquid dressing of embodiment 1 to 4 and reference examples 1 to 3 is carried out every bacterium performance test, specifically such as respectively Under.

Material:

1. bacterial strain: staphylococcus aureus reference culture increases visible colonies typical after bacterium on culture medium, and can Normal passage.

2. dressing: the chitosan liquid dressing of embodiment 1 to 4 and reference examples 1 to 3.

Experiment:

In agarose media plate, the chitosan liquid dressing of embodiment 1 to 4 is by the clear of 0.7mL every square centimeter Lotion dosage and the film forming agent dosage of 0.3mL every square centimeter are sprayed on media surface respectively.Reference examples 1 to 3 press every square li The dosage of rice 1mL is sprayed on media surface.The rectangular dressing of 40mm × 40mm is formed, covers culture dish lid after spraying dressing, to It forms a film.After 5min, culture dish lid is taken away, staphylococcus aureus aerosol is sprayed in media surface, covers culture dish Lid.It sets 37 DEG C of cultures for 24 hours, observes at dressing covering and do not cover place's bacterium colony upgrowth situation.

Then remove dressing, by remove dressing after culture medium set 37 DEG C continue culture for 24 hours, observe covering at do not cover Locate the upgrowth situation of bacterium colony.Every group of dressing operates continuously 3 times to observe reproducibility.Observe embodiment dressing and control group dressing Bacterium colony growing state result is as shown in table 3 below at the original dressing covering of culture medium center.

Table 3

By upper table 3 it is found that 1 to 3 dressing culture medium center original dressing of reference examples covering is in when dressing is not taken off and throws off deposited Material all has bacterium colony growth after continuing culture for 24 hours, and bacterium colony growth rate size is 1 > reference examples of reference examples, 2 > reference examples 3.Implement Sterile length of being born at the culture medium center original dressing covering of 1 to 4 dressing of example, and rest part then covers with bacterium, does not throw off deposited State when material is identical with the state that dressing continues after culture for 24 hours is thrown off, and illustrates that the chitosan liquid of embodiment 1 to 4 applies Material has every bacterium efficiency, and has certain persistence, this chitosan liquid dressing for being commercially available reference examples 1 cannot achieve 's.

It should be noted that the other embodiments of the application further include, the mutually group of the technical characteristic in the various embodiments described above Close the chitosan liquid dressing that is formed by, can implement.

Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.

The several embodiments of the application above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously The limitation to claim therefore cannot be interpreted as.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the concept of this application, various modifications and improvements can be made, these belong to the protection of the application Range.Therefore, the scope of protection shall be subject to the appended claims by the application.

Claims (10)

1. a kind of chitosan liquid dressing, which is characterized in that the film forming agent of cleaning agent and liquid including liquid, and the cleaning Agent and the film forming agent are separately positioned；

The cleaning agent and the film forming agent all have constituent of chitosan；Wherein, it is 0.5% that the cleaning agent, which has mass ratio, ~5% constituent of chitosan；It is 2%~12% constituent of chitosan that the film forming agent, which has mass ratio,.

2. chitosan liquid dressing according to claim 1, which is characterized in that the cleaning agent is with constituent of chitosan Physiological saline.

3. chitosan liquid dressing according to claim 1, which is characterized in that the cleaning agent is with constituent of chitosan The Benza that mass ratio is 0.01%~0.05%.

4. chitosan liquid dressing according to claim 1, which is characterized in that the cleaning agent is with constituent of chitosan The ethanol solution that volume ratio is 70%~75%.

5. chitosan liquid dressing according to claim 1, which is characterized in that it is 1% that the cleaning agent, which has mass ratio, ~4% constituent of chitosan.

6. chitosan liquid dressing according to claim 1, which is characterized in that it is 3% that the film forming agent, which has mass ratio, ~10% constituent of chitosan.

7. chitosan liquid dressing according to claim 1, which is characterized in that the film forming agent is Watery film-fomer.

8. chitosan liquid dressing according to claim 1, which is characterized in that the film forming agent is selected from albumen film forming agent, third One of olefin(e) acid resin film former, polyethylene kind copolymer, hydrocarbon type copolymer, organosilicon polymer or Si acrylate are more Kind.

9. according to claim 1 to chitosan liquid dressing described in any one of 8, which is characterized in that the constituent of chitosan choosing From chitosan, organic selenium molecular chitosan derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginates or carboxylic first One of base enclosure glycan is a variety of.

10. chitosan liquid dressing according to claim 9, which is characterized in that the cleaning agent has with the film forming agent Different constituent of chitosan.