CN109200326A - Dressing and bandage for wound healing - Google Patents
Dressing and bandage for wound healing Download PDFInfo
- Publication number
- CN109200326A CN109200326A CN201810799396.9A CN201810799396A CN109200326A CN 109200326 A CN109200326 A CN 109200326A CN 201810799396 A CN201810799396 A CN 201810799396A CN 109200326 A CN109200326 A CN 109200326A
- Authority
- CN
- China
- Prior art keywords
- dressing
- wound
- layer
- amino acid
- bandage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention provides a kind of dressing and bandage for wound healing.Wherein, dressing includes dressing matrix, and hypochlorous acid and/or hypochlorite and amino acid and/or amino acid chloramines are mixed in the dressing matrix, and the pH value of the dressing is 3.0~7.0.Using technical solution of the present invention, wound can effectively be sterilized, and accelerate the healing of wound.In addition, using technical solution of the present invention also without additional side effect, the healing well of wound can be allowed.
Description
Technical field
The present invention relates to pharmaceutical technology fields, in particular to a kind of dressing and bandage for wound healing.
Background technique
Skin is the maximum institutional framework of human body, not only has the function of body heat regulation and adjusts internal water balance,
The even more the first line of defence of human defense external world cause of disease invasion, and when widespread skin injury, it is likely to result in body function
It is unbalance, internal organs numerous imbalances, or even thus it is dead.In general, skin wound is after drug-treated, still can be with clothing or outer
Boundary's contact, accidentally may lead to the situation of wound deterioration because of the dust being collided or be infected in air or bacterium,
Therefore in order to which wound to be avoided is exposed in air, people would generally cover or wrap up one on processed wound by sterilization
The artificial skin dressing of processing, which is done, to be completely cut off.
Treatment of the medical institutions to human external wound at present, such as incised wound, scratch, surgical incision, ulcer or burn
Deng dressing that usually must be sterilized in the equal site of injury mulching or wrapping, to prevent from being infected by extraneous bacterium.General doctor
Treating the dressing that mechanism is commonly used includes gauze, alginate dressing, hydrophilic dressing, aqueous gel dressing etc., is both needed to frequent dressing,
It is most absolutely that the sterilized made cotton pad of cotton is pressed from both sides still between gauze or two layers of gauze, in use, mulching or wrapping are in wound
On, for shallow layer trauma, though there is the effect of absorbing wound exudate, precisely because still having sepage bleeds back corrosion periwound skin,
Thus cause to infect, also or the sepage for absorptions is easy to volatilize and make gauze be hardened thus injury wound etc. lack.Furthermore for
Chronic and big wound is not easy to heal, and be easy to cause bacterium or virus infection and causes more serious consequence, such as honeycomb group
Scorching or fatal septicemia is knitted, in order to accelerate the healing of wound, and lowers the infection of wound, in the research of disinfecting, antimicrobial dressing
It is really necessary to be improved in development.
Especially for there is infected wound existing for bacterium, it is necessary to carry out debridement and deteriorate to avoid subsequent infection, infect
Property wound be a kind of pollution wound, amount of bacteria be even more interfere wound healing important factor, by bacterium/microorganism infection it
Wound may cause healing and delay or heal bad or even downright bad, and the infection of wound not only hinders agglutination, atypia occurs
The risk of scar is also significantly increased.Based on this theoretical basis, how from the first stage that wound restores bacterium sense is just effectively avoided
Dye, and how to accelerate the recuperation of subsequent wound for the important key of antiseptic dressing research and development now.
Although treating wound in wet condition at this stage more effectively, have more high risk vulnerable to bacterium infection, but
Bacterium infection is handled using antibiotic can develop drug resistance bacterium, and therefore, antiseptic dressing product is mostly that dressing infiltration disappears at present
Toxic agent ingredient such as hexamethylene belongs to non-antibiotic class.Due to hexamethylene antibacterial agent energy
Inhibit the growth of bacterium, reduce infection and the formation of skin microbial bacterium colony, and can inhibit on a variety of wounds common bacteria such as: gold
Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Methicillin-resistant Staphylococcus color staphylococcus, thus it is long
It has been widely used since long as medical disinfectant and is combined as antiseptic dressing with dressing.However it is aobvious according to European Union's recent research
Show, hexamethylene has anxious toxicity, therefore on January 1st, 2015 it is banned for skin contact it
Cosmetics and medical product, and there is the risk of anxious toxicity in dressing and skin contact containing hexamethylene,
Therefore there should be substitute products to be improved.
Additionally, it is known that Ag-containing compound can have antimicrobial effect under the priming the pump for generating resistance.
Therefore, be improve dressing easily by microorganism or the problem of bacterium infection, have using Inorganic Ag System Antimicrobial Agents (such as: silver from
Son), to inhibit the growth and breeding of bacterium, to reach the chance for reducing wound infection as antiseptic dressing.Its principle system is because of silver
Ion, which can act on the cell wall of bacterium, replicate cell wall can not, can also destroy bacterial cell respiratory chain, block cell
Energy supply, or even the characteristics such as breed cell can not are acted directly on DNA or ribonucleic acid.But argentiferous
Its silver ion emission of dressing is not easy to control, and is generally acknowledged that silver ion can make DNA lose replication protein organism
Ability, while can also be formed and be bonded with certain functional groups on protein, thus make protein damage.Many researchs in recent years are
It is verified, it can be generated using silver dressings to human liver, kidney organ's cell damage, it is more than to easily lead to wounds streamed blood, also right
Environmental ecology does great damage, and therefore, European Union disables on January 1st, 2016 in the medical product with skin contact.
It follows that existing dressing for wound healing, have the shortcomings that healing effect is bad and side effect more than
Disadvantage.
Summary of the invention
The main purpose of the present invention is to provide a kind of dressing and bandage for wound healing, to solve the prior art
Middle dressing is existing to act on wound healing bad problem.
To achieve the goals above, according to an aspect of the invention, there is provided a kind of heal for treating wound help
Dressing, including dressing matrix is mixed with hypochlorous acid and/or hypochlorite and amino acid and/or amino acid chlorine in dressing matrix
Amine, the pH value of dressing are 3.0~7.0.
Further, parts per million concentration of the hypochlorous acid in dressing matrix is 1~20000.
Further, the weight ratio of hypochlorous acid and/or hypochlorite and amino acid and/or amino acid chloramines be 2:1~
20:1。
Further, chitin or chitosan are also mixed in dressing matrix, chitin or chitosan and hypochlorous acid
Weight ratio be 10:1~1:40.
Further, amino acid is taurine and/or glycine and/or alanine and/or valine and/or leucine
And/or isoleucine and/or phenylalanine and/or tryptophan and/or tyrosine and/or aspartic acid and/or histidine and/or
Asparagine and/or glutamic acid and/or lysine and/or glutamine and/or methionine and/or arginine and/or silk ammonia
Acid and/or threonine and/or cysteine and/or proline.
Further, amino acid chloramines is that amino acid reacts generation with hypochlorous acid.
Further, dressing matrix is made of the transparent material of high-hydroscopicity, the transparent material absorbable 10 of high-hydroscopicity
The medicament of~100 times of own wt ratios.
Further, dressing matrix is calcium alginate dressings or bearing hydrocolloid dressing or aerogel dressing or foam dressing.
To achieve the goals above, according to an aspect of the invention, there is provided a kind of bandage, including bandage ontology
With the dressing being placed on bandage ontology, dressing is above-mentioned dressing.
Further, bandage ontology includes topical application of drug layer and adhered layer, and dressing is placed on topical application of drug layer, adhered layer and topical application of drug layer
It is connected.
Further, topical application of drug layer is hyaline layer, and hyaline layer is for observing wound healing situation.
Further, topical application of drug layer is air-permeable layer, and air-permeable layer can be used for directly spraying drug to dressing.
Further, adhered layer is connected to around topical application of drug layer, to prevent the dressing on topical application of drug layer from falling off after stickup.
It applies the technical scheme of the present invention, wound can effectively be sterilized, and accelerate the healing of wound.In addition,
Using technical solution of the present invention also without additional side effect, the healing well of wound can be allowed.
Other than objects, features and advantages described above, there are also other objects, features and advantages by the present invention.
Below with reference to figure, the present invention is described in further detail.
Detailed description of the invention
The Figure of description for constituting a part of the invention is used to provide further understanding of the present invention, and of the invention shows
Examples and descriptions thereof are used to explain the present invention for meaning property, does not constitute improper limitations of the present invention.In the accompanying drawings:
Fig. 1 shows the overlooking structure diagram of the embodiment of bandage according to the present invention；
Fig. 2 shows the cross section structure schematic diagrams of the embodiment of the bandage of Fig. 1；
Fig. 3 shows general glue dressing figure compared with dressing experimental study of the invention；
Fig. 4 shows the recovery situation of the hypochlorous acid for selecting different proportion and taurine during instilling wound 21 days
Compare figure.
Wherein, the above drawings include the following reference numerals:
10, topical application of drug layer；20, adhered layer.
Specific embodiment
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
In order to enable those skilled in the art to better understand the solution of the present invention, below in conjunction in the embodiment of the present invention
Attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only
The embodiment of a part of the invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
The model that the present invention protects all should belong in member's every other embodiment obtained without making creative work
It encloses.
It should be noted that description and claims of this specification and term " first " in above-mentioned attached drawing, "
Two " etc. be to be used to distinguish similar objects, without being used to describe a particular order or precedence order.It should be understood that using in this way
Term be interchangeable under appropriate circumstances, so as to the embodiment of the present invention described herein.In addition, term " includes " and " tool
Have " and their any deformation, it is intended that cover it is non-exclusive include, for example, containing a series of steps or units
Process, method, system, product or equipment those of are not necessarily limited to be clearly listed step or unit, but may include without clear
Other step or units listing to Chu or intrinsic for these process, methods, product or equipment.
It should be noted that term used herein above is merely to describe specific embodiment, and be not intended to restricted root
According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singular
Also it is intended to include plural form, additionally, it should be understood that, when in the present specification using term "comprising" and/or " packet
Include " when, indicate existing characteristics, step, operation, device, component and/or their combination.
The present invention provides a kind of embodiments of dressing for wound healing, which includes dressing matrix, in dressing
Hypochlorous acid and amino acid are mixed in matrix, the pH value of dressing is 3.0~7.0.Optionally, amino acid is taurine.
As an alternative embodiment, it can also be mixed with hypochlorous acid and amino acid chloramines in dressings, dressing
PH value is 3.0~7.0.Optionally, amino acid is taurine chloramines.
As a kind of highly preferred embodiment, it is mixed with hypochlorous acid, amino acid and amino acid chloramines in dressings, applies
The pH value of material is 3.0~7.0, and the effect of the dressing is optimal.
As other optional embodiments, it is mixed with hypochlorite and amino acid or amino acid chloramines in dressings
Be it is feasible, the pH value of the dressing is 3.0~7.0.In this embodiment, due to hypochlorous acid (HOCl) manufacture generate in addition to
It can be by chlorine (Cl2) dissolution generation is reacted with water, or electrolysis hydrochloric acid (HCl) generates, or penetrates hypochlorite
(OCl-) it is acidified the balanced reaction that (H+) produces hypochlorous acid (HOCl).
Cl2+H2O—>HOCl+HCl
HCl-> electrolysis-> HOCl
OCl-+H+—>HOCl
As other optional embodiments, be mixed in dressings hypochlorite and hypochlorous acid and amino acid and/
Or amino acid chloramines, the pH value of the dressing are 3.0~7.0.
Preferably, in the inventive solutions, the hypochlorous acid and/or hypochlorite and the amino acid and/or
The weight ratio of the amino acid chloramines is 2:1~20:1.
It should be noted that hypochlorous acid is the main component that human immune system's neutrophil is used to eliminating bacteria.
When human body is invaded by germ, white blood cell will start system of defense and automatically generate hypochlorous acid to eliminate external germ.Hypochlorous acid tool
There is powerful oxidation, energy Quick disinfection deodorization and sterilization destroys rapidly harmful microbe cell after contacting with microorganism
Film destroys the virus protein spike being adsorbed on cell membrane, such as Escherichia coli, staphylococcus aureus, tulase, cholera arc
The protein component of the cell membrane of bacterium, salmonella, bacteriophage etc. can make its death that loses activity that falls off.And hypochlorous acid with it is micro-
It is reduced to water immediately after biology and organic matter reaction.Due to hypochlorous acid bio-compatibility with it is highly-safe, and in sterilization
Task after the completion of be reduced into water, it is free of a burden to environment the problem of non-residual toxicity, it is very environmentally friendly.
A kind of substance that amino acid contains if taurine is mankind's brain script, will cause tired sense when lacking, because
This can achieve the effect refreshed oneself through supplement of taurine, and it is also beneficial to body in addition to this to absorb micro taurine, therefore
Often by the nutrition adding ingredient as baby milk.Taurine is for example anti-oxidant etc. there are many basic biological action, it is also
Cardiovascular and skeletal muscle, retina and the indispensable nutritional ingredient of central nervous system are generated, wound can be helped to be added
Speed is repaired.Amino acid chloramines as taurine chloramines then it is adjustable promote to generate be present in blood and being exposed to organizes in environment
Dendritic Cells, as skin and nose, lung, stomach and small intestine epithelial tissue, its effect, which is adjusted, stimulates current environment
The reaction of congenital and acquired immunity accelerates cell repair growth.
Using the above embodiments, using similar with Human neutrophils' white blood cell immune system nontoxic, nonirritant
Hypochlorous acid ingredient can effectively kill the germ of wound.Meanwhile in order to allow wound more effectively to heal, wound location can be gradually
New capilary is grown, using taurine or the good immune repair function accelerating wound healing of taurine chloramines, acceleration of wound
The hyperplasia of face epithelium heals, and promotes the regeneration of wound cambium, brings more collagen tissues to fill up wound, in wound healing
In a complete interference-free plane, collagen tissue is elongated and marshalling, and scar becomes flat and light.In this way, using this
The dressing of invention, so that it may wound effectively be sterilized, and accelerate the healing of wound.In addition, using dressing of the invention
Also without additional side effect, the healing well of wound can be allowed.
It should be noted that the selection of amino acid, other than taurine, glycine, alanine, valine, bright is selected
Propylhomoserin, isoleucine, phenylalanine, tryptophan, tyrosine, aspartic acid, histidine, asparagine, glutamic acid, lysine,
One of glutamine, methionine, arginine, serine, threonine, cysteine or proline are a variety of, according to upper
Ratio is stated come using being also feasible.
It should also be noted that, above-mentioned amino acid chloramines may be that amino acid is reacted with the hypochlorous acid and generated.
Preferably, in the inventive solutions, parts per million concentration of the hypochlorous acid in dressing matrix be 1~
20000.Through overtesting, when parts per million concentration of the hypochlorous acid in dressing matrix is 1~20000, good kill can be played
Bacterium effect.More preferably, the pH value of dressing is 3.0~9.0, to be adapted to the use of human body.
As an alternative embodiment, chitin or chitosan are also mixed in dressing matrix, chitin or several
Fourth glycan and hypochlorous weight ratio are 10:1~1:40.Chitin or chitosan have good quick-acting haemostatic powder and antibacterial
Function, bio-compatibility is very high with safety, therefore is widely used in food and medical application.By chitin or chitin
Highly compatible that glycan is possessed, antibacterial and other effects can help hemostatic function, by the quick anti-inflammatory of wound, and then reduce They hurt
Bitterly, wound face is made quickly to tide over the post-hemorrhagic period/inflammation phase in the first and second stage of wound.
Optionally, in the inventive solutions, dressing matrix is made of the transparent material of high-hydroscopicity.Using this kind
The hydrophilic antibiotic bleeding-stopping dressing matrix of Wound healing and bone regeneration is to provide for wound moist healing environment and designs, when this dressing base
When matter is covered on wound, sterilization can be generated to the bacterial micro-organism on wound, and absorb the diffusate of wound, be formed
One piece of soft absorber can help wound healing acceleration to maintain wound moist.More preferably, in technology of the invention
In scheme, dressing matrix is glue, and the manufacture of glue substrate can be used, have 10-100 times of weight ratio water absorption character, avoid oozing out
Liquid immersion periwound skin can protect wound to avoid by external bacterium infection, avoid being stained with skin glutinous friction or
Other injuries cause wound deterioration, have the transparency, retractility, stickiness, have vision penetrability, are convenient for later observation wound shape
Condition.It can be directly by outside sprinkling antimicrobial formulation to help wound disinfection moisturizing and healing acceleration, without daily more after covering wound
It changes, avoids the tearing of wound, reduce interference wound collagen tissue arrangement, and facilitate the smooth no scar of wound healing.
Optionally, other than selection glue is as dressing matrix, calcium alginate dressings, aerogel dressing or foam dressing are selected
It is also feasible.
The present invention also provides a kind of bandage, which includes bandage ontology and is placed in deposited on bandage ontology
Material, dressing are above-mentioned dressing.Using the bandage of above-mentioned dressing, wound can effectively be sterilized, and accelerate wound
Healing.In addition, the bandage also without additional side effect, can allow the healing well of wound.
As depicted in figs. 1 and 2, in the embodiment of bandage of the invention, bandage ontology includes topical application of drug layer 10 and glues
Paste layer 20, dressing are placed on topical application of drug layer 10, and adhered layer 20 is connected with topical application of drug layer 10.In use, will be equipped with by adhered layer 20 deposited
The topical application of drug layer 10 of material is attached on wound, and dressing is allowed to treat wound.As a preferred embodiment, adhered layer 20 connects
It is connected to around topical application of drug layer 10, to prevent the dressing on topical application of drug layer 10 from falling off after stickup.Optionally, as shown in Figure 1, topical application of drug layer
10 is rectangular, and adhered layer 20 is distributed in around topical application of drug layer 10, play the role of applying dressing is strict in wound.
Optionally, in the inventive solutions, topical application of drug layer 10 is hyaline layer.In this way, 10 He of topical application of drug layer can be penetrated
Hydrophily transparent dressing matrix observes wound healing situation, avoids and tears or remove dressing and hinder and damage wound healing.
As a kind of more preferably embodiment, in the present embodiment, topical application of drug layer 10 is air-permeable layer, and air-permeable layer can be used for
Drug is directly sprayed to dressing.In this way, medicament can directly be sprayed in carrying out absorption exchange on topical application of drug layer 10, reduce dry when dressing
It disturbs wound Skin Cell and wound is kept to carry out disinfection in moist environment and sterilize healing acceleration.
As shown in the above, in the inventive solutions:
Utilize applying based on nontoxic, nonirritant hypochlorous acid ingredient similar with Human neutrophils' white blood cell immune system
Material, can keep wound surface humidity, and the highly compatible that is possessed by chitosan, antibacterial and other effects can help hemostatic function,
By the quick anti-inflammatory of wound, and then wound pain is reduced, makes wound face that the post-hemorrhagic period/inflammation in the first and second stage of wound be rapidly completed
Phase.Entering proliferative phase phase III repair process, in order to allow wound more effectively to heal, wound location can gradually grow new micro-
Blood vessel cooperates the good immune repair function accelerating wound healing of taurine and taurine chloramines, the increasing of acceleration of wound face epithelium
Raw healing, promotes the regeneration of wound cambium, more collagen tissues is brought to fill up wound, and the groundwork in this stage is to protect
Wound moist is held, wound is helped to build an excellent healing environment.Fourth stage is the mature remodeling phase, and wound healing is complete one
When whole interference-free plane, collagen tissue is elongated and marshalling, and scar becomes flat and light, if but wound by dry
It disturbs, collagen is misaligned, will generate ugly scar.The dressing matrix of glue can absorb wound fluid and avoids infiltration rotten
Periwound skin is lost, can protect wound that friction or other injuries is avoided to cause wound deterioration, there is the transparency, convenient for observation wound
Mouth situation.It can be penetrated directly by outside sprinkling hypochloric acid water or liquid antibiotic prescription medicament in glue dressing after covering wound
Liquid absorption exchange contact skin, to help wound disinfection moisturizing and healing acceleration.
This dressing provides the smooth plane of wound one and need not replace daily, and the number for reducing dressing avoids tearing for wound
It splits, reduces interference wound collagen tissue arrangement, facilitate the smooth no scar of wound healing.This antibiotic property dressing is penetrated with vision
Property, can directly observe the change of wound, avoid hindering and damaging wound without tearing or removing dressing, can be with as the kenel of dressing
It is aqueous solution kenel or gel kenel or solid ingot dosage form state etc., as long as having after and mixing compatible with formula of the invention
Having can help the characteristic person of wound healing applicable.
Patient wound's hemostasis is provided using dressing of the invention and bandage technology, antibacterial, deodorization, anti-inflammatory, accelerates wound
The effect of mouth healing and attenuating scar generate.It not only can promote blood coagulation reaction and quickly eliminate bacterium and microorganism on wound,
Reach the chance for reducing wound infection, the healing of wound can also be accelerated.The present invention is in four stages of traumatic wounds healing
All have more preferably healing effect and accelerate speed, wound can be provided it is best look after, for than existing all dressing more rapidly,
More comfortable, safer, more effective Wound healing and bone regeneration mode.
Specifically, using following specific embodiments as explanation:
By glue and the hypochlorous acid of preparation, taurine, taurine chloramines, mixing is sufficiently stirred in chitosan aqueous solution makes into
Jelly with stickiness, by filling dressing specification mold in it is dry it is fixed-type after, be removed from the molds molding
Dressing is sealed in the packaging bag with air exclusion；Or by the hypochlorous acid of preparation, taurine, taurine chloramines, chitosan
Aqueous solution and hydrophilic dressing basis are sealed in the packaging bag with air exclusion after coming into full contact with absorption.Dressing is taken when use
Be covered in the wound of sanitized out, and can spray disinfectant agent for several times daily as follows chloric acid aqueous solution above dressing, with
Keep dressing and wound moist.
1: being tested by Textile Industry Research Institute
Prepare 2 groups of glue dressing samples to be tested, sample 1 is simple commercially available glue dressing, and sample 2 is glue dressing base
Matter and hypochlorous acid, taurine, taurine chloramines, chitosan are formulated mixed liquor complete wetting 30 minutes.By 1x105Bacterial strain stoste
It is applied to above-mentioned 2 groups of dressing to be tested, with aseptic water washing surface and detects bacterium number Ma immediately within 0 hour, after culture in 18 hours
Bacterium number Mb.According to the explanation of JIS L1902, when bacteriostatic activity value is 2.0 or more, indicate that sample has antibacterial deodourizing effect, when
When bactericidal activity value is 0 or more, indicate that sample has bacterium effect processed.Sample bacteriostatic activity value of the present invention is 5.7, bactericidal activity value is
3.2, indicate the antibacterial and bacterium effect processed that have splendid.
Other than 1 bacterium mass propagation of control group, the bacterium in the dressing of sample sets 2 shows all without growth as the result is shown
Show that the antiseptic dressing of the present invention has the effect of disinfection and sterilization.
Following table is Textile Industry Research Institute dressing antibacterial tests test result
Note: 1. measuring units are Textile Industry Research Institute, and sample 1 is glue dressing, and sample 2 is formula containing hypochlorous acid
Glue dressing.
2. plant bacteria concentration indicates that test is set up in 1.0~3.0E+5 (bacterium number/milliliter).
3.Ma with aseptic water washing surface and detects bacterium number immediately in 0 hour, Mb, bacterium number after culture in 18 hours, due to detection
Dilution ratio, < 20 is without the marker methods for detecting bacterium.
4. proliferation value=LogMa-LogMb, proliferation value >=1.0 expression tests are set up.
Bacteriostatic activity value=control group 5. (LogMb-LogMa)-sample sets (LogMb-LogMa).
6. bactericidal activity value=sample sets (LogMa-LogMb).
7. the explanation according to JIS L1902: when bacteriostatic activity value is 2.0 or more, indicate that sample has antibacterial deodourizing effect,
When bactericidal activity value is 0 or more, indicate that sample has bacterium effect processed.
Antibacterial tests research is carried out again for following two constituents, and constituent 1 is general glue dressing, and constituent 2 is
The sample (dressing matrix+hypochlorous acid+taurine+chitin) that the present invention develops.
2: general glue dressing and antibiotic property glue dressing test one of the invention
This test is with 105The clump count (Escherichia coli) of CFU/ml is tested, and bacterium is applied directly to constituent 1
On, and by bacterium drop on the constituent 2 of slice, 3 days after testing under 37 DEG C of temperature environments, observe antibacterial effect totally after 72 hours
Fruit.
Fig. 3 is general glue dressing compared with dressing experimental study of the invention, and condition of culture is to test 3 under 37 °
It.Result of study shows that third day constituent 1 (general glue dressing) has a large amount of bacterial growths, therefore shows without good antibacterial effect
Fruit, and constituent 2 (dressing+hypochlorous acid+taurine+chitin) is all without bacterial growth, therefore show the dressing of the present invention with pole
Good sterilization effect.
3: general glue dressing and antibiotic property glue dressing test two of the invention
It is shown for constituent according to result of study, constituent 1 is to Pseudomonas aeruginosa, streptococcus, Escherichia coli all without antibacterial
Effect, and the constituent 2 that the present invention is developed has splendid sterilization effect.
This test is with 105The clump count (Pseudomonas aeruginosa, streptococcus Escherichia coli) of CFU/ml is tested, and bacterium is direct
It is applied on constituent 1, and by bacterium drop on the constituent 2 of slice, 3 days after testing under 37 DEG C of temperature environments, totally 72 is small
When after observe antibacterial effect.Result of study shows that third day constituent 1 (general glue dressing) has a large amount of bacterial growths, therefore shows
Without good fungistatic effect, and constituent 2 (dressing+hypochlorous acid+taurine+chitin) is all without bacterial growth, therefore shows the present invention
Dressing have splendid sterilization effect.
Following table is antibacterial tests effect detection contrast table
+: representative has bacterial growth, and+number represents amount of bacteria number
+++: amount of bacteria is more
: without bacterial growth
4: the antibacterial tests of hypochlorous acid and taurine different proportion mixed component
The present invention tests antibacterial effect again with the constituent that hypochlorous acid, taurine are mixed, respectively with hypochlorous acid: ox sulphur
Acid=2:1, hypochlorous acid: the mixing of taurine=4:1, for Candida albicans, turn sugar chain coccus, porphyromonas gingivalis with
106CFU/ml clump count is tested.
With hypochlorous acid: taurine=2:1 mixing constituent will react completely, formation taurine chloramines, however ox sulphur
Sour chloramines is in antibacterial test to Candida albicans but without good inhibitory effect.On the contrary, the hypochloric acid water that the present invention is developed
With good sterilization effect, with hypochlorous acid: the constituent that taurine=4:1 ratio mixing generates can generate hypochlorous acid and ox sulphur
The disinfection of two kinds of ingredients of sour chloramines, the more single taurine chloramines of the antibacterial experiment result of this complex chemical compound performs better, and is all in
Now it is greater than 99.9999% complete sterilizing rate, for Candida albicans, turns sugar chain coccus, porphyromonas gingivalis and all test to have
Effect.
Following table is antibacterial tests effect detection contrast table
+: representative has bacterial growth, and+number represents amount of bacteria number
+++ ++: amount of bacteria is very more
: without bacterial growth
5: hypochlorous acid and taurine different proportion mixed component are in the comparative studies of mouse Wound healing and bone regeneration effect
The effect of in addition to antibacterial, hypochlorous acid, taurine are mixed and made into Wound antibiotic healing formula by the present invention, for testing
Wound healing effect, respectively with hypochlorous acid: taurine=2:1, hypochlorous acid: taurine=4:1 mixing is hurt in mouse or so daily
Each instillation 50ml constituent is observed continuously 21 days on mouth, wound healing situation of every 7 days records.
According to wound repair physical characteristic, wound healing shares four stages: post-hemorrhagic period, inflammation phase, proliferative phase and maturation weight
The modeling phase.Previous document is shown with hypochlorous acid: taurine=2:1 mixing constituent will react completely, form taurine chlorine
Amine, it is helpful to wound reparation, but can successively decrease at any time on wound recovery mechanisms of human body itself, therefore itself sends out the inflammation phase
Scorching bactericidal effect is limited, or even inhibits inflammatory process, causes to postpone the hyperplasia of subsequent wound cells, fibrosis maintenance stage.
Fig. 4 shows the experiment feelings of the dressing comprising hypochlorous acid, taurine, Amino acid chloramines, chitin and dressing matrix
Shape.The hypochlorous acid and taurine for selecting different proportion in this experiment, recovery situation during instilling wound 21 days.Through
This test confirms, uses hypochlorous acid: it is still aobvious to the effect of Wound healing and bone regeneration that taurine=2:1 reacts generated taurine chloramines
Deficiency, and with hypochlorous acid: taurine=4:1 ratio mixing can generate hypochlorous acid and part taurine chloramines, extra hypochlorous acid
There can be very quick good anti-inflammatory effect to the second stage (inflammation phase) that wound restores with the bacterial reaction on wound,
And through hyperplasia, the fibrosis maintenance of the taurine chloramines acceleration wound cells proliferative phase and maturity period being combined into point.By animal
Experiment is it can be observed how this obvious difference is different, and also the compositely proportional formula of the confirmation present invention has Wound healing and bone regeneration more preferably
Repairing effect.
Unless specifically stated otherwise, positioned opposite, the digital table of the component and step that otherwise illustrate in these embodiments
It is not limited the scope of the invention up to formula and numerical value.Simultaneously, it should be appreciated that for ease of description, each portion shown in attached drawing
The size divided not is to draw according to actual proportionate relationship.For technology, side known to person of ordinary skill in the relevant
Method and equipment may be not discussed in detail, but in the appropriate case, and the technology, method and apparatus should be considered as authorizing explanation
A part of book.In shown here and discussion all examples, any occurrence should be construed as merely illustratively, and
Not by way of limitation.Therefore, the other examples of exemplary embodiment can have different values.It should also be noted that similar label
Similar terms are indicated in following attached drawing with letter, therefore, once it is defined in a certain Xiang Yi attached drawing, then subsequent attached
It does not need that it is further discussed in figure.
For ease of description, spatially relative term can be used herein, as " ... on ", " ... top ",
" ... upper surface ", " above " etc., for describing such as a device shown in the figure or feature and other devices or spy
The spatial relation of sign.It should be understood that spatially relative term is intended to comprising the orientation in addition to device described in figure
Except different direction in use or operation.For example, being described as if the device in attached drawing is squeezed " in other devices
It will be positioned as " under other devices or construction after part or construction top " or the device of " on other devices or construction "
Side " or " under other devices or construction ".Thus, exemplary term " ... top " may include " ... top " and
" in ... lower section " two kinds of orientation.The device can also be positioned with other different modes and (is rotated by 90 ° or in other orientation), and
And respective explanations are made to the opposite description in space used herein above.
In the description of the present invention, it is to be understood that, the noun of locality such as " front, rear, top, and bottom, left and right ", " it is laterally, vertical,
Vertically, orientation or positional relationship indicated by level " and " top, bottom " etc. is normally based on orientation or position shown in the drawings and closes
System, is merely for convenience of description of the present invention and simplification of the description, in the absence of explanation to the contrary, these nouns of locality do not indicate that
It must have a particular orientation or be constructed and operated in a specific orientation with the device or element for implying signified, therefore cannot manage
Solution is limiting the scope of the invention；The noun of locality " inside and outside " refers to inside and outside the profile relative to each component itself.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (13)
1. a kind of for treating wound the dressing for helping to heal, which is characterized in that including dressing matrix, mixed in the dressing matrix
Conjunction has hypochlorous acid and/or hypochlorite and amino acid and/or amino acid chloramines, and the pH value of the dressing is 3.0~7.0.
2. dressing according to claim 1, which is characterized in that part per million of the hypochlorous acid in the dressing matrix
Concentration is 1~20000.
3. dressing according to claim 1, which is characterized in that the hypochlorous acid and/or hypochlorite and the amino acid
And/or the weight ratio of the amino acid chloramines is 2:1~20:1.
4. dressing according to claim 1, which is characterized in that be also mixed with chitin in the dressing matrix or chitin is poly-
Sugar, the chitin or the chitosan and the hypochlorous weight ratio are 10:1~1:40.
5. dressing according to claim 1, which is characterized in that the amino acid is taurine and/or glycine and/or third
Propylhomoserin and/or valine and/or leucine and/or isoleucine and/or phenylalanine and/or tryptophan and/or tyrosine and/
Or aspartic acid and/or histidine and/or asparagine and/or glutamic acid and/or lysine and/or glutamine and/or first
Methyllanthionine and/or arginine and/or serine and/or threonine and/or cysteine and/or proline.
6. dressing according to claim 5, which is characterized in that the amino acid chloramines is the amino acid and the secondary chlorine
Acid reaction generates.
7. dressing according to claim 1, which is characterized in that the dressing matrix by high-hydroscopicity transparent material system
At the transparent material of the high-hydroscopicity can absorb the medicament of 10~100 times of own wt ratios.
8. dressing according to claim 7, which is characterized in that the dressing matrix is calcium alginate dressings or bearing hydrocolloid dressing
Or aerogel dressing or foam dressing.
9. a kind of bandage, including bandage ontology and the dressing being placed on the bandage ontology, which is characterized in that described to apply
Material is dressing described in any item of the claim 1 to 8.
10. bandage according to claim 9, which is characterized in that the bandage ontology includes topical application of drug layer (10) and glues
Paste layer (20), the dressing are placed on the topical application of drug layer (10), and the adhered layer (20) is connected with the topical application of drug layer (10).
11. bandage according to claim 9, which is characterized in that the topical application of drug layer (10) is hyaline layer, the hyaline layer
For observing wound healing situation.
12. bandage according to claim 11, which is characterized in that the topical application of drug layer (10) is air-permeable layer, described ventilative
Layer can be used for directly spraying drug to dressing.
13. bandage according to claim 10, which is characterized in that the adhered layer (20) is connected to the topical application of drug layer
(10) around, to prevent the dressing on the topical application of drug layer (10) from falling off after stickup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810799396.9A CN109200326A (en) | 2018-07-19 | 2018-07-19 | Dressing and bandage for wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810799396.9A CN109200326A (en) | 2018-07-19 | 2018-07-19 | Dressing and bandage for wound healing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109200326A true CN109200326A (en) | 2019-01-15 |
Family
ID=64990107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810799396.9A Pending CN109200326A (en) | 2018-07-19 | 2018-07-19 | Dressing and bandage for wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109200326A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
| CN111407791A (en) * | 2020-03-16 | 2020-07-14 | 鄂州职业大学 | External traditional Chinese medicine care solution for promoting wound healing |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091346A (en) * | 2010-01-15 | 2011-06-15 | 东华大学 | Bacterial cellulose-based antibacterial dry film for acute trauma and preparation method and application thereof |
| US20110236450A1 (en) * | 2010-03-29 | 2011-09-29 | The Clorox Company | Polyelectrolyte complexes |
| CN102335452A (en) * | 2011-09-22 | 2012-02-01 | 边俊杰 | Formula of functional dressing and preparation method thereof |
| US20130287836A1 (en) * | 2010-08-30 | 2013-10-31 | President And Fellows Of Harvard College | High strength chitin composite material and method of making |
| CN106943429A (en) * | 2016-06-28 | 2017-07-14 | 黄坚文 | The preparation method of hypochlorite solution a kind of and its clinical medicine application |
| CN108079017A (en) * | 2017-11-27 | 2018-05-29 | 义乌市中科院兰州化物所功能材料中心 | Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compound or derivative |
| CN108159074A (en) * | 2018-01-05 | 2018-06-15 | 广州润虹医药科技股份有限公司 | It is a kind of for hypochlorous acid chitosan Wound-protection liquid of wound healing and preparation method thereof |
-
2018
- 2018-07-19 CN CN201810799396.9A patent/CN109200326A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091346A (en) * | 2010-01-15 | 2011-06-15 | 东华大学 | Bacterial cellulose-based antibacterial dry film for acute trauma and preparation method and application thereof |
| US20110236450A1 (en) * | 2010-03-29 | 2011-09-29 | The Clorox Company | Polyelectrolyte complexes |
| US20130287836A1 (en) * | 2010-08-30 | 2013-10-31 | President And Fellows Of Harvard College | High strength chitin composite material and method of making |
| CN102335452A (en) * | 2011-09-22 | 2012-02-01 | 边俊杰 | Formula of functional dressing and preparation method thereof |
| CN106943429A (en) * | 2016-06-28 | 2017-07-14 | 黄坚文 | The preparation method of hypochlorite solution a kind of and its clinical medicine application |
| CN108079017A (en) * | 2017-11-27 | 2018-05-29 | 义乌市中科院兰州化物所功能材料中心 | Hypochlorous acid wound disinfectant containing antibacterial polysaccharide compound or derivative |
| CN108159074A (en) * | 2018-01-05 | 2018-06-15 | 广州润虹医药科技股份有限公司 | It is a kind of for hypochlorous acid chitosan Wound-protection liquid of wound healing and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 帕苏普来蒂等: "《功能食品、血糖健康与Ⅱ型糖尿病》", 31 January 2012 * |
| 霍孝蓉 译: "《泛太平洋地区压力性损伤的防治临床实践指南》", 30 June 2014 * |
| 韩瑞发等: "《肾移植分子免疫基础与临床》", 31 October 2005 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
| CN111407791A (en) * | 2020-03-16 | 2020-07-14 | 鄂州职业大学 | External traditional Chinese medicine care solution for promoting wound healing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104274490B (en) | Bactericidal composition including source of silver ions and menthol and application thereof | |
| CN105012993B (en) | A kind of cation Medical Living Creature Gum antiseptic dressing and preparation method thereof | |
| EP2515869B1 (en) | Wound care products | |
| CN109316536A (en) | A kind of skin mucosa disinfecting agent and preparation method thereof | |
| CN105055642A (en) | Compound guanidine disinfectant and preparation method of compound guanidine disinfectant | |
| CN106344956A (en) | Chitosan antibacterial gel with effect of promoting healing and method for preparing chitosan antibacterial gel | |
| CN109331219A (en) | A kind of chitosan liquid dressing | |
| CN105079858B (en) | Liquid dressing and its preparation method are repaired in a kind of wound sterilization | |
| WO2007100917A2 (en) | Antimicrobials and related methods | |
| CN106947095B (en) | A kind of preparation method for wound healing antibacterial type hydrogel | |
| CN102335452A (en) | Formula of functional dressing and preparation method thereof | |
| CN106361816A (en) | Wound disinfecting spraying film agent and preparation method thereof | |
| CN101543658B (en) | Cervical cap for preventing and treating cervical erosion and preparation method thereof | |
| CN104971377A (en) | Liquid wound glue and preparation method | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| CN104474573A (en) | Biological mask and preparation method thereof | |
| CN103249419B (en) | There is antibacterial and wound healing activity compositions | |
| CN106581699B (en) | A kind of antibacterial type sterile solid medical supersonic coupled patch and preparation method thereof | |
| CN111991417A (en) | Hypochlorous acid gel with physiological responsiveness and application thereof in skin wound surface | |
| CN111500490A (en) | Microbial type bacteriostatic and odor-removing preparation as well as preparation method and application thereof | |
| CN114652767B (en) | Dairy cow nipple medicated bath agent and preparation method thereof | |
| CN106563129A (en) | Composition for wound protection and dressing formed by composition | |
| CN104666317B (en) | A kind of neonatal umbilical cord antibacterial anti-inflammatory liquid and its preparation method and application | |
| CN101755763A (en) | Disinfection composition for preventing and treating livestock and poultry breeding diseases and prepration method and application thereof | |
| CN107753937A (en) | A kind of wound disinfection agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |