CN102335452A - Formula of functional dressing and preparation method thereof - Google Patents
Formula of functional dressing and preparation method thereof Download PDFInfo
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- CN102335452A CN102335452A CN2011102826718A CN201110282671A CN102335452A CN 102335452 A CN102335452 A CN 102335452A CN 2011102826718 A CN2011102826718 A CN 2011102826718A CN 201110282671 A CN201110282671 A CN 201110282671A CN 102335452 A CN102335452 A CN 102335452A
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- chitosan
- quaternary ammonium
- ammonium salt
- functional dressing
- collagen protein
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Abstract
The invention discloses functional dressing having three functions of antibiosis, hemostasis and wound healing promoting and a preparing method thereof. The functional dressing is a novel compound preparation which makes use of a sodium chloride solution subjected to electrochemical treatment as a solvent and contains dialkyl quaternary ammonium salt, chlorhexidine acetate, chitosan, collagen and the like as main active ingredients. The functional dressing has obvious inhibitory activity for the growth of a variety of pathogenic bacteria, and has no irritation to skin and mucosa, and is suitable for the treatments of skin, mucosa and wound infection and has the function of sterilization treatment of sites subjected to surgery and injection, wound surfaces (all types of surgical incisions, I-II burn, scald, open trauma surgery) and suppurative wound infection, mucosal sterilization, itching relieving and wound healing promoting.
Description
Technical field
The present invention relates to a kind of medical material and preparation method thereof, specifically a kind of prescription and method for preparing that has antibiotic, hemostasis and promote the functional dressing of wound healing.
Technical background
The method of traditional treatment skin or mucosa, wound surface damage is to cover or process the plaster form with powdery medicine; As with Plant fiber's gauze as drug administration carrier; Carry the method that is covered in wound surface behind the medicine, it is convenient inadequately to use, and also is not suitable for the mucosa medication.Along with improving constantly of demand, novel medicinal functional dressing engenders, like various disinfectant.There is following problem in existing functional dressing at present:
One, still is liquid after the present mostly existing liquid dressing spraying, sticks dust easily, also be prone to be attached on the medicated clothing, when therefore using this kind liquid dressing, avoid affected part to contact as far as possible with other material.Like the liquid dressing of some Chinese medicine extract preparation (application number 200610045985.5 and 200510046942.4 Chinese invention patent application) and some disinfectant solution.And the present invention can form the solid breathable films after being sprayed on affected part, the protection wound surface.
Two, mostly existing functional dressing all is confined to sterilizing function, promptly in prescription, has only antibacterial and adjuvant, and does not have other effects, as disinfectant solution.And the present invention also has the function of hemostasis, promotion wound healing except that having sterilizing function.
Three, the biological degradability of the film former of some film-formable liquid functional property dressing uses in spraying back is relatively poor; The application of only suitable skin superficial wound is like the Auxiliary Liquid Material of processing with polyvinyl alcohol and acrylic acid ester emulsion pressure sensitive adhesive (the Chinese invention patent application of application number 200610012150).
Four, mostly with an organic solvent for the liquid dressing of solvent has zest, can make patient's feels pain, be difficult to stand, need to use anesthetis to ease the pain.
Five, some as the functional dressing of antibacterial, can cause the residual of heavy metal, to health unfavorable (the Chinese invention patent application of application number 200610083191.8) with nanometer silver or other heavy metals.
Summary of the invention
The present invention's technical problem at first to be solved is a kind of antibiotic, hemostasis to be provided and to promote the functional dressing of wound healing to above problem.For this reason, the present invention adopts following technical scheme: it be sodium chloride solution with electrochemical treatments as solvent, containing dialkyl quaternary ammonium salt, chlorhexidine acetate, chitosan and collagen protein is active component.
Described in the sodium chloride solution of electrochemical treatments, the content of hypochlorite is 30-100mg/L, and the content of chloride ion is 20-80mg/L.
The content of dialkyl quaternary ammonium salt is 1-1900mg/L, and described dialkyl quaternary ammonium salt is selected from dodecyl quaternary ammonium salt, two decyl quaternary ammonium salt, two nonyl quaternary ammonium salt, two octyl group quaternary ammonium salt, can be one or more combination of these materials
The weight content of chitosan is 0.01-1.5%; Described chitosan is high chitosan, oligo-chitosan or chitosan derivatives, and chitosan is selected from carboxymethyl chitosan, sulphuric acid carboxymethyl chitosan, sulphuric acid chitosan, using carboxyl chitosan, sulfuration chitosan, hydroxylating chitosan, chitosan quaternary ammonium salt.
The molecular weight of said chitosan is between 1500-3000, and deacetylation is 70-95%.
The content of chlorhexidine acetate is 1-1900mg/L.
The weight content of collagen protein is 0.01-1.5%, and collagen protein is selected from fiber collagen, microfibre collagen, lung fiber collagen protein, basement membrane collagen, the netted collagen of hexagon, grappling collagen protein, strides film collagen protein, basement membrane collagen protein.
Another technical problem to be solved of the present invention provides a kind of method for preparing of above-mentioned functions property dressing.For this reason; The present invention adopts following technical scheme: chitosan, collagen protein, chlorhexidine acetate and dialkyl quaternary ammonium salt are dissolved in respectively in the sodium chloride solution after the electrochemical treatments; Again with each solution mix homogeneously, be used for sodium chloride solution and be settled to required volume and get final product.
Further, the dissolving method of chitosan is: get chitosan in right amount to beaker, an amount of swelling of the sodium chloride solution after the electrochemical treatments leaves standstill, and can not drip spirit of vinegar if do not dissolve, and is stirred to dissolving while dripping and places 1-2h.
The present invention with dialkyl quaternary ammonium salt, chlorhexidine acetate and sodium hypochlorite be antibacterial, utilize the hemostasis of chitosan and glutin and promote wound healing function, prepare as solvent with the sodium chloride solution of electrochemical treatments, be applicable to the treatment of skin, mucosa and traumatic infection.
Chitosan is the product of chitin N-deacetylation, is a kind of natural straight chain shape aminopolysaccharide.Chitosan has characteristics such as good film property, permeability, adsorptivity, biological degradability, biocompatibility and Bioabsorbable, widely pays close attention to.Chitosan can promote fibroblastic migration, and stromal cell is had chemotactic, migration, activated effect, and quickens cell proliferation and tissue remodeling process, promotes skin tissue recovering, and accelerating wound healing and anastalsis are arranged.The network structure of chitosan makes it to have the prevention tissue adhesion, suppresses physiological functions such as cicatrization and protection articular cartilage.
The main sterilization mechanism of chitosan is that chitosan molecule gets in the bacterial cell; Destroy DNA transcribing to RNA; Cause bacterial reproduction termination or positively charged chitosan molecule to adsorb electronegative bacteria cell wall, make its respiration inhibition and death through coulomb interaction.Experiment shows that the fungicidal effectiveness of chitosan is relevant with its molecular weight and deacetylation, and with mean molecule quantity 1500-3000, the fungicidal effectiveness of the chitosan of deacetylation 90-95% is best.
Though chitosan has certain sterilizing function, its bactericidal effect is unsatisfactory.Therefore the present invention adds dialkyl quaternary ammonium salt and chlorhexidine acetate as antibacterial, and bactericidal effect is significantly increased.Chlorhexidine acetate is two valency cationic surfactants; Antibacterial there is tangible affinity, has sterilization effect preferably, and nonirritant, be ideal skin antiseptic; Be again a kind of broad spectrum antimicrobicide simultaneously, gram positive bacteria and gram negative bacteria are all had stronger antibacterial action.Dialkyl quaternary ammonium salt uses existing very long history as antibacterial, the bactericidal action of having found cationic surfactant from nineteen thirty-five Domagk so far, discovered four generation quaternary ammonium salt bactericide, the bactericidal action of strong effect is all arranged for antibacterial, fungus etc.Moreover, the hypochlorite in the solvent for use of the present invention also has bactericidal action.
Collagen protein is distributed widely in positions such as skin, joint, and its molecular surface has many polar side chains, makes to have extraordinary water absorbing properties, can absorb the tissue fluid that wound oozes out, and avoids suppurating sore.Collagen protein can activate local coagulation process and generate the blood clot that fibrin polymer constitutes, and forms firm thrombosis with platelet, and control over bleeding is a kind of good hemorrhage.Collagen protein depends on and stent material as the cell growth, can breed, break up and divide a word with a hyphen at the end of a line by inducing cell, has the effect that promotes wound healing.Moreover, collagen protein also has excellent biological compatibility and degradability.
The present invention unites the use biodegradable chitosan and collagen protein can strengthen hemostasis mutually, promote wound healing effect as film former; " Auxiliary Liquid Material " in the past (the Chinese invention patent application of application number 200410092818.7) though used chitin and collagen protein as film former; But what antibacterial used is first generation quaternary ammonium salt antibacterial oradol; Toxicity is bigger, and the antibacterial among the present invention uses third generation quaternary ammonium salt bactericide dialkyl quaternary ammonium salt, and toxicity is very low.And, various bacteria, fungus, mycoplasma, virus all there are killing action, better effects if with chlorhexidine acetate and sodium hypochlorite assisting sterilisation.
Based on above-mentioned substance physiologically active separately, the present invention serves extensive patients with its compatibility to prepare a kind of multi-functional liquid functional property dressing.Functional dressing provided by the invention has broad spectrum antibacterial; Pathogenic bacterium such as escherichia coli, mycete, staphylococcus aureus all there is good killing action; And to skin and mucosa nonirritant; Be applicable to the treatment of skin, mucosa and traumatic infection, comprise operation, injection site sterilization processing, wound surface (all kinds of operative incisions, I-II burn, scald, open wound operation), suppurative wound infection, mucosa antibacterial, antipruritic and promotion wound healing.
The specific embodiment
Embodiment 1:
The 200mg/L sodium chloride solution is 40mg/L through electrolysis to hypochlorite ion's content, as solution A.Get dialkyl quaternary ammonium salt 1.5g, chlorhexidine acetate 0.8g, collagen protein 0.8g respectively, with the dissolving of 100mL solution A, be configured to solution separately, respectively as solution B, C, D.Other gets in the beaker of chitosan 0.8g to 1L, with solution A 300mL swelling, leaves standstill, and can drip spirit of vinegar as not dissolving, and is stirred to dissolving while dripping, and places 1h.Above-mentioned B, C, D solution poured in the beaker mix with chitosan solution, add solution A again and supply volume, after stirring, fill, radiation sterilization get final product.
Embodiment 2:
The sodium chloride solution of 150mg/L is 30mg/L through electrolysis to hypochlorite ion's content, as solution A.Get dialkyl quaternary ammonium salt 1.5g, chlorhexidine acetate 0.5g, collagen protein 0.6g respectively, with the dissolving of 100mL solution A, be configured to solution separately, respectively as solution B, C, D.Other gets in the beaker of chitosan 0.5g to 1L, with solution A 300mL swelling, leaves standstill, and can drip spirit of vinegar as not dissolving, and is stirred to dissolving while dripping, and places 1h.Above-mentioned B, C, D solution poured in the beaker mix with chitosan solution, add solution A again and supply volume, after stirring, fill, radiation sterilization get final product.
Embodiment 3:
The sodium chloride solution of 100mg/L is 20mg/L through electrolysis to hypochlorite ion's content, as solution A.Get dialkyl quaternary ammonium salt 1.5g, chlorhexidine acetate 1.0g, collagen protein 1.0g respectively, with the dissolving of 100mL solution A, be configured to solution separately, respectively as solution B, C, D.Other gets in the beaker of chitosan 1.0 to 1L, with solution A 300mL swelling, leaves standstill, and can drip spirit of vinegar as not dissolving, and is stirred to dissolving while dripping, and places 1h.Above-mentioned B, C, D solution poured in the beaker mix with chitosan solution, add solution A again and supply volume, after stirring, fill, radiation sterilization get final product.
Above-mentioned embodiment is merely and is used for illustrative explanation the present invention, rather than limits the invention, and any modification that the present invention is made, is equal to replacement, improvement etc., all falls into protection scope of the present invention.
Claims (9)
1. functional dressing, it is characterized in that it be sodium chloride solution with electrochemical treatments as solvent, containing dialkyl quaternary ammonium salt, chlorhexidine acetate, chitosan and collagen protein is active component.
2. functional dressing according to claim 1 is characterized in that describedly in the sodium chloride solution of electrochemical treatments, and the content of hypochlorite is 30-100mg/L, and the content of chloride ion is 20-80mg/L.
3. functional dressing according to claim 1, the content that it is characterized in that dialkyl quaternary ammonium salt is 1-1900mg/L, described dialkyl quaternary ammonium salt is selected from dodecyl quaternary ammonium salt, two decyl quaternary ammonium salt, two nonyl quaternary ammonium salt, two octyl group quaternary ammonium salt.
4. functional dressing according to claim 1; The weight content that it is characterized in that chitosan is 0.01-1.5%; Described chitosan is high chitosan, oligo-chitosan or chitosan derivatives, and chitosan is selected from carboxymethyl chitosan, sulphuric acid carboxymethyl chitosan, sulphuric acid chitosan, using carboxyl chitosan, sulfuration chitosan, hydroxylating chitosan, chitosan quaternary ammonium salt.
5. according to claim 1 or 4 described functional dressing, the molecular weight that it is characterized in that said chitosan is between 1500-3000, and deacetylation is 70-95%.
6. functional dressing according to claim 1, the content that it is characterized in that chlorhexidine acetate is 1-1900mg/L.
7. functional dressing according to claim 1; The weight content that it is characterized in that collagen protein is 0.01-1.5%, and collagen protein is selected from fiber collagen, microfibre collagen, lung fiber collagen protein, basement membrane collagen, the netted collagen of hexagon, grappling collagen protein, strides film collagen protein, basement membrane collagen protein.
8. the method for preparing of the described functional dressing of claim 1; It is characterized in that in the sodium chloride solution after chitosan, collagen protein, chlorhexidine acetate and dialkyl quaternary ammonium salt are dissolved in electrochemical treatments respectively; Again with each solution mix homogeneously, be used for sodium chloride solution and be settled to required volume and get final product.
9. method for preparing as claimed in claim 8; The dissolving method that it is characterized in that chitosan is: get chitosan in right amount to beaker, an amount of swelling of the sodium chloride solution after the electrochemical treatments leaves standstill; Can not drip spirit of vinegar if do not dissolve, be stirred to dissolving while dripping and place 1-2h.
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| CN2011102826718A CN102335452A (en) | 2011-09-22 | 2011-09-22 | Formula of functional dressing and preparation method thereof |
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| CN2011102826718A CN102335452A (en) | 2011-09-22 | 2011-09-22 | Formula of functional dressing and preparation method thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736134A (en) * | 2013-12-30 | 2014-04-23 | 深圳先进技术研究院 | Medical sponge dressing and preparation method thereof |
| CN103800939A (en) * | 2014-02-14 | 2014-05-21 | 武汉烺祺生物科技有限公司 | Antibacterial healing-functional dressing and preparation method thereof |
| CN104257411A (en) * | 2014-09-19 | 2015-01-07 | 陈旭东 | Interventional puncture needle passage hemostatic particle and implanting gun matched with same |
| CN105256650A (en) * | 2015-10-05 | 2016-01-20 | 福建农林大学 | Multifunctional nanocellulose supported lactic acid/chitosan drug-loaded nano microsphere paper-making paint and preparing method thereof |
| CN107753309A (en) * | 2016-08-15 | 2018-03-06 | 任汉学 | Disinfection hand cleanser and preparation method thereof |
| CN107929795A (en) * | 2017-11-16 | 2018-04-20 | 北京华信佳音医疗科技发展有限责任公司 | A kind of preparation and its application of antibacterial anti hemorrhagic material |
| CN108014366A (en) * | 2017-12-15 | 2018-05-11 | 青岛海洋生物医药研究院 | A kind of marine organism material composite hydrogel dressing and preparation method thereof |
| CN108186671A (en) * | 2018-01-10 | 2018-06-22 | 王江桥 | For eliminating the hypertonic salt solution and application method of various skin infection diseases |
| CN109157646A (en) * | 2018-10-10 | 2019-01-08 | 杭州普瑞美克生物科技有限公司 | The preparation method of the clean negative antimicrobial spray of the stream of people and combined preparation |
| CN109200326A (en) * | 2018-07-19 | 2019-01-15 | 丁力行 | Dressing and bandage for wound healing |
| CN111330069A (en) * | 2020-03-09 | 2020-06-26 | 蔡钧 | External dressing and preparation method and application thereof |
Citations (2)
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| CN1775303A (en) * | 2004-11-16 | 2006-05-24 | 周广刚 | Liquid dressing |
| CN101987201A (en) * | 2010-02-11 | 2011-03-23 | 北京德存华盛医疗器械有限公司 | Medical ultrasonic probe sterilizing gel and preparation method thereof |
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| CN1775303A (en) * | 2004-11-16 | 2006-05-24 | 周广刚 | Liquid dressing |
| CN101987201A (en) * | 2010-02-11 | 2011-03-23 | 北京德存华盛医疗器械有限公司 | Medical ultrasonic probe sterilizing gel and preparation method thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103736134A (en) * | 2013-12-30 | 2014-04-23 | 深圳先进技术研究院 | Medical sponge dressing and preparation method thereof |
| CN103736134B (en) * | 2013-12-30 | 2015-04-29 | 深圳先进技术研究院 | Medical sponge dressing and preparation method thereof |
| CN103800939A (en) * | 2014-02-14 | 2014-05-21 | 武汉烺祺生物科技有限公司 | Antibacterial healing-functional dressing and preparation method thereof |
| CN103800939B (en) * | 2014-02-14 | 2015-09-02 | 武汉烺祺生物科技有限公司 | A kind of antibacterial healing functional dressing and preparation method thereof |
| CN104257411A (en) * | 2014-09-19 | 2015-01-07 | 陈旭东 | Interventional puncture needle passage hemostatic particle and implanting gun matched with same |
| CN105256650A (en) * | 2015-10-05 | 2016-01-20 | 福建农林大学 | Multifunctional nanocellulose supported lactic acid/chitosan drug-loaded nano microsphere paper-making paint and preparing method thereof |
| CN107753309A (en) * | 2016-08-15 | 2018-03-06 | 任汉学 | Disinfection hand cleanser and preparation method thereof |
| CN107929795A (en) * | 2017-11-16 | 2018-04-20 | 北京华信佳音医疗科技发展有限责任公司 | A kind of preparation and its application of antibacterial anti hemorrhagic material |
| CN108014366A (en) * | 2017-12-15 | 2018-05-11 | 青岛海洋生物医药研究院 | A kind of marine organism material composite hydrogel dressing and preparation method thereof |
| CN108014366B (en) * | 2017-12-15 | 2021-05-14 | 青岛海洋生物医药研究院 | Marine biological material composite hydrogel dressing and preparation method thereof |
| CN108186671A (en) * | 2018-01-10 | 2018-06-22 | 王江桥 | For eliminating the hypertonic salt solution and application method of various skin infection diseases |
| CN109200326A (en) * | 2018-07-19 | 2019-01-15 | 丁力行 | Dressing and bandage for wound healing |
| CN109157646A (en) * | 2018-10-10 | 2019-01-08 | 杭州普瑞美克生物科技有限公司 | The preparation method of the clean negative antimicrobial spray of the stream of people and combined preparation |
| CN111330069A (en) * | 2020-03-09 | 2020-06-26 | 蔡钧 | External dressing and preparation method and application thereof |
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Application publication date: 20120201 |