CN103736134A - Medical sponge dressing and preparation method thereof - Google Patents
Medical sponge dressing and preparation method thereof Download PDFInfo
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- CN103736134A CN103736134A CN201310743416.8A CN201310743416A CN103736134A CN 103736134 A CN103736134 A CN 103736134A CN 201310743416 A CN201310743416 A CN 201310743416A CN 103736134 A CN103736134 A CN 103736134A
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Abstract
The invention provides medical sponge dressing. The medical sponge dressing comprises polyvinyl alcohol, aloe vera and an antibacterial agent, wherein the polyvinyl alcohol takes the shape of a three-dimensional mesh, the aloe vera and the antibacterial agent are loaded on the surface and in the polyvinyl alcohol, the polyvinyl alcohol, the aloe vera and the antibacterial agent form a composite material with micropores, and the masses of the polyvinyl alcohol, the aloe vera and the antibacterial agent respectively account for 79-94.5%, 5-20% and 0.5-1% in the total mass of the composite material. The invention also provides a preparation method of medical sponge dressing, which comprises: mixing the polyvinyl alcohol, the aloe vera and the antibacterial agent, freezing and unfreezing to prepare the medical sponge dressing. The medical sponge dressing can absorb a large amount of wound exudate, and meanwhile, has the advantages of being antibacterial and anti-inflammatory, moisturizing and relieving pain, absorbing exudate, preventing adhesion and effectively promoting wound healing, and the like.
Description
Technical field
The present invention relates to a kind of medical sponge dressing and preparation method thereof.
Background technology
Medical dressing is a class clinical medical material that temporarily covers the wounds such as burn, ulcer and wound, and its Main Function is that transudate and the protection wound of in wound healing process, controlling wound are avoided the external source pollutions such as antibacterial and grit.Polyvinyl alcohol (PVA) sponge is a kind of non-fiber, have the material of loose structure, there is stable chemical property and good biocompatibility, and there is good hydrophilic, imbibition, the performance of sucking blood and good antibiont degradation property, with low cost, in medical dressing field, have broad application prospects.
But, polyvinyl alcohol medical grade sponge does not possess antibacterial function, for easy infection or the infected wound suitability is poor, in order to obtain having the polyvinylalcohol sponge of anti-microbial property, in prior art, conventionally polyvinylalcohol sponge is immersed in antibacterials, the mode by physical absorption is in conjunction with antibacterials, because antibacterials are only combined by physics mode with polyvinylalcohol sponge, medicine is easy to separate from carrier, does not have good antibacterial curative effect; Prior art is also by making antibacterials powder or liquid, after mixing with polyvinyl alcohol material, foaming agent and cross-linking agent etc. again, carry out again the polyvinylalcohol sponge that foaming obtains having anti-microbial property, due to the impact of the chemicals such as foaming agent and cross-linking agent, the drug effect of antibacterials and the biocompatibility of polyvinylalcohol sponge can be affected.Therefore, how to prepare the emphasis that medical sponge dressing that anti-microbial property is good becomes current research.
Summary of the invention
For addressing the above problem, the invention provides a kind of medical sponge dressing and preparation method thereof, described medical sponge dressing is absorbing wound exudates in a large number, have good antibacterial action simultaneously.
First aspect, the invention provides a kind of medical sponge dressing, described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on the surperficial and inner of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the quality of described polyvinyl alcohol, Aloe and antibacterial accounts for respectively 79%～94.5%, 5%～20% and 0.5%～1% of described composite gross mass.
The micropore of described composite is positioned at the surperficial and inner of composite.
Preferably, the micropore size of described composite material surface is 1 μ m～5 μ m.
Preferably, the micropore size of described composite inner is 20 μ m～50 μ m.
Preferably, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
More preferably, described chitosan quaternary ammonium salt derivatives is hydroxypropyltrimethyl ammonium chloride chitosan.
In prior art, Aloe is the herbaceous plant that a kind of medical value is very high, it has the pharmacological actions such as antibacterial, antiinflammatory, immunomodulating, short granulation tissue formation, moisturizing and analgesia, can be used for antibacterial, detumescence and promoting granulation, repair tissue damage and wound healing etc.Existing research also shows, adopts the wound surface epithelization of Aloe early, can effectively promote wound healing.
Poly-own methylene hydrochloric acid (PHMB) is a kind of 21 century broad spectrum antimicrobicide the most safely and efficiently that is acknowledged as, it is low that it has Mlc, wide spectrum low toxicity, speed of action is fast, effective time is long, and can not make antibacterial produce the advantages such as drug resistance, be widely used at present the fields such as medical apparatus and instruments, household and food.
Chitosan quaternary ammonium salt derivatives has good bacteria resistance and moisture absorbability and moisture retentivity, and has kept the performances such as the original good film property of chitosan, biocompatibility and biodegradation.
Medical sponge dressing provided by the invention comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on the surperficial and inner of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described medical sponge dressing can be protected wound well, tridimensional network and microcellular structure can make described medical sponge dressing absorbing wound exudates in a large number, keep wound surface moisture state, play the effect of " moistening healing ", promote the healing of wound, and wound can not bond, avoid causing secondary insult, Aloe has the effect of antiinflammatory and the formation of short granulation tissue, impaired epithelial cell is also had to promotion repair simultaneously, promotes wound healing, the bactericidal effect of antibacterial is good, during use, can not make antibacterial produce drug resistance, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on described tridimensional network, described tridimensional network is closely wrapped in Aloe and antibacterial wherein, and difficult drop-off in use, after described medical sponge dressing contacts with wound surface, antibacterial and Aloe described in can slow release, the antibacterial effect of performance persistent high efficiency and promote the effect of wound healing.
Described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the micropore of described composite is positioned at the surperficial and inner of composite, and the surface apertures of described composite is 1 μ m～5 μ m, and inner aperture is 20 μ m～50 μ m.The surface apertures that described medical sponge dressing is less can effectively intercept antibacterial and harmful particle, can prevent wounded tissue bonding simultaneously, avoids causing secondary insult; The aperture, inside that described medical sponge dressing is larger can make a large amount of absorbing wound exudates of described medical sponge dressing, there is good absorbability and larger absorptive capacity, keep wound surface moisture state simultaneously, play the effect of " moistening healing ", promote the healing of wound.
The quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79%～94.5%, 5%～20% and 0.5%～1% of described composite gross mass.Described in this under mass fraction, the load of Aloe and antibacterial can not stopped up the tridimensional network of polyvinyl alcohol completely, thereby can not affect the effect of a large amount of absorbing wound exudates of polyvinyl alcohol, simultaneously, the tridimensional network of polyvinyl alcohol can adsorb Aloe and antibacterial well, make antibacterial and Aloe difficult drop-off, the antibacterial effect with promoting wound healing of more lasting performance.
Medical sponge dressing of the present invention has advantages of inhibiting bacteria and diminishing inflammation, moisturizing analgesia, imbibition is anti-stick and effective wound healing, can be widely used in treating infected wound, ulcer in body surface, various burn and scald and injure the bio-medical fields such as surgical wound.
Second aspect, the invention provides a kind of preparation method of medical sponge dressing, comprises the following steps:
(1) will after aloe frozen-dried powder dissolving, obtain aloe water solution;
(2) will after polyvinyl alcohol material dissolving, obtain polyvinyl alcohol water solution;
(3) described aloe water solution and described polyvinyl alcohol water solution are mixed to get to the first mixed solution, in described the first mixed solution, add antibacterial, after stirring, obtain the second mixed solution;
(4) described the second mixed solution is injected to mould, the thickness of described the second mixed solution in described mould is 50 μ m～500 μ m, standing 4～8h at 4 ℃, subsequently at-20 ℃～-80 ℃ freezing 4h～24h, again at 20 ℃～30 ℃ 1h～4h that thaw, repeated freezing and thawing 1～6 time, obtain gel, by described gel successively lyophilization, cut out after packing and sterilizing, obtain described medical sponge dressing, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on the surperficial and inner of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described polyvinyl alcohol, the quality of Aloe and antibacterial accounts for respectively 79%～94.5% of described composite gross mass, 5%～20% and 0.5%～1%.
The micropore of described composite is positioned at the surperficial and inner of composite.
Preferably, the micropore size of described composite material surface is 1 μ m～5 μ m.
Preferably, the micropore size of described composite inner is 20 μ m～50 μ m.
Preferably, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
More preferably, described chitosan quaternary ammonium salt derivatives is hydroxypropyltrimethyl ammonium chloride chitosan.
Preferably, described in step (1), aloe frozen-dried powder is obtained by purchase.
Preferably, described in step (1), the solvent in aloe water solution is distilled water.
Preferably, described in step (1), in aloe water solution, the mass concentration of Aloe is 0.1%～2%.
Preferably, described in step (2), the molecular weight of polyvinyl alcohol material is 60,000～200,000.
Preferably, described in step (2), the alcoholysis degree of polyvinyl alcohol material is 88%～99.9%.
Preferably, described in step (2), the solvent in polyvinyl alcohol water solution is distilled water.
Preferably, described in step (2), in polyvinyl alcohol water solution, the mass concentration of polyvinyl alcohol is 10%～25%.
Preferably, in step (2) by described polyvinyl alcohol material heating for dissolving at 90 ℃.
Preferably, sterilizing methods described in step (4) is sterilizing or Co 60 sterilizing under High Temperature High Pressure.
Preferably, the described mould in step (4) is politef mould.
In prior art, Aloe is the herbaceous plant that a kind of medical value is very high, it has the pharmacological actions such as antibacterial, antiinflammatory, immunomodulating, short granulation tissue formation, moisturizing and analgesia, can be used for antibacterial, detumescence and promoting granulation, repair tissue damage and wound healing etc.Existing research also shows, adopts the wound surface epithelization of Aloe early, can effectively promote wound healing.
Poly-own methylene hydrochloric acid (PHMB) is a kind of 21 century broad spectrum antimicrobicide the most safely and efficiently that is acknowledged as, it is low that it has Mlc, wide spectrum low toxicity, speed of action is fast, effective time is long, and can not make antibacterial produce the advantages such as drug resistance, oneself is widely used in the fields such as medical apparatus and instruments, household and food at present.
Chitosan quaternary ammonium salt derivatives has good bacteria resistance and moisture absorbability and moisture retentivity, and has kept the performances such as the original good film property of chitosan, biocompatibility and biodegradation.
After the present invention mixes polyvinyl alcohol, Aloe and antibacterial, carrying out freeze-thaw, polyvinyl alcohol carries out physical crosslinking when freeze-thaw, polyvinyl alcohol molecule interchain is by hydrogen bond and micro-crystal zone formation tridimensional network, described Aloe and antibacterial are carried in described tridimensional network, polyvinyl alcohol can closely wrap up Aloe and antibacterial, and the medical sponge dressing pore size making is even, and absorbability is strong.
Described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on the surperficial and inner of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described medical sponge dressing can be protected wound well, tridimensional network and microcellular structure can make described medical sponge dressing absorbing wound exudates in a large number, keep wound surface moisture state, play the effect of " moistening healing ", promote the healing of wound; The tridimensional network of described polyvinyl alcohol is closely wrapped in Aloe and antibacterial wherein, and Aloe has the effect of antiinflammatory and the formation of short granulation tissue, impaired epithelial cell is also had to promotion repair simultaneously; Antibacterial bactericidal effect is good, during use, can not make antibacterial produce drug resistance, simultaneously, described Aloe and antibacterial are closely wrapped in the network structure of polyvinyl alcohol, difficult drop-off in use, after described medical sponge dressing contacts with wound surface, can slow release described in antibacterial and Aloe, the antibacterial effect of performance persistent high efficiency and promote the effect of wound healing.
Described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the micropore of described composite is positioned at the surperficial and inner of composite, and the surface apertures of described composite is 1 μ m～5 μ m, and inner aperture is 20 μ m～50 μ m.The surface apertures that described medical sponge dressing is less can effectively intercept antibacterial and harmful particle, can prevent wounded tissue bonding simultaneously, avoids causing secondary insult; The aperture, inside that described medical sponge dressing is larger can make a large amount of absorbing wound exudates of described medical sponge dressing, there is good absorbability and larger absorptive capacity, keep wound surface moisture state simultaneously, play the effect of " moistening healing ", promote the healing of wound.
The quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79%～94.5%, 5%～20% and 0.5%～1% of described composite gross mass.Under described mass fraction, the load effect of Aloe and antibacterial can not stopped up the tridimensional network of polyvinyl alcohol completely, thereby can not affect the effect of a large amount of absorbing wound exudates of polyvinyl alcohol, simultaneously, polyvinyl alcohol carries out physical crosslinking when freeze-thaw, the tridimensional network forming can wrap up Aloe and antibacterial well, makes antibacterial and Aloe difficult drop-off, the antibacterial effect with promoting wound healing of more lasting performance.
Medical sponge dressing of the present invention has advantages of inhibiting bacteria and diminishing inflammation, moisturizing analgesia, imbibition is anti-stick and effective wound healing, can be widely used in treating infected wound, ulcer in body surface, various burn and scald and injure the bio-medical fields such as surgical wound.
Polyvinyl alcohol of the present invention forms tridimensional network by physical crosslinking, not and the chemical reagent such as cross-linking agent react, thereby the more hydroxyl in polyvinyl alcohol molecule can form hydrogen bond with water and absorb water better, improved the water absorbing properties of medical sponge dressing.
The present invention without adding foaming agent and cross-linking agent, can not exert an influence to the biocompatibility of the drug effect of Aloe and antibacterial and described medical sponge dressing in preparation process, environmental protection, and preparation method technique is simple, cost is low.
To sum up, beneficial effect of the present invention comprises the following aspects:
(1) medical sponge dressing of the present invention has advantages of inhibiting bacteria and diminishing inflammation, moisturizing analgesia, imbibition is anti-stick and effective wound healing;
(2) the preparation process environmental protection of medical sponge dressing of the present invention, preparation technology is simple, and cost is low.
Accompanying drawing explanation
Fig. 1 is the surface topography map of the medical sponge dressing that makes of embodiment 1;
Fig. 2 is the cross-sectional morphology figure of the medical sponge dressing that makes of embodiment 1;
Fig. 3 is the fungistatic effect figure of the medical sponge dressing that makes of embodiment 1 to Staphylococcus aureus;
Fig. 4 is that the medical sponge dressing that makes of embodiment 1 is to colibacillary fungistatic effect figure.
The specific embodiment
The following stated is the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Embodiment mono-
(1) aloe frozen-dried powder is dissolved in in distilled water, to obtain mass concentration be 1% aloe water solution, is placed in 4 ℃ of refrigerators and stores for future use;
(2) polyvinyl alcohol material that by molecular weight be 60,000, alcoholysis degree is 99.9% is dissolved in distilled water at 90 ℃, and to obtain mass concentration be 10% polyvinyl alcohol water solution;
(3) polyvinyl alcohol water solution that aloe water solution step (1) being obtained and step (2) obtain is mixed to get the first mixed solution, adds poly-own methylene hydrochloric acid in the first mixed solution, obtains the second mixed solution after stirring;
(4) the second mixed solution is injected to politef mould, the thickness of the second mixed solution in politef mould is 50 μ m, standing 4h at 4 ℃, subsequently at-80 ℃ of freezing 24h, again at 25 ℃ of 4h that thaw, obtain gel, by gel successively lyophilization, cut out packing, after autoclave sterilization, obtain medical sponge dressing, it is three-dimensional netted that polyvinyl alcohol is, Aloe and poly-own methylene hydrochloric acid are carried on the surperficial and inner of polyvinyl alcohol, polyvinyl alcohol, Aloe and poly-own methylene hydrochloric acid form the composite with micropore, polyvinyl alcohol, the quality of Aloe and poly-own methylene hydrochloric acid accounts for 94.5% of composite gross mass, 5% and 0.5%.
Adopt scanning electron microscope to observe respectively the surface topography map of medical sponge dressing and the cross-sectional morphology figure of medical sponge dressing that embodiment 1 makes; Result is referring to Fig. 1 and Fig. 2, as can be seen from Figure 1, the medical sponge dressing surface making has a large amount of micropores, the micropore size on surface is 1 μ m～5 μ m, and as can be seen from Figure 2, the medical sponge dressing making is three-dimensional netted, inner micropore size is 20 μ m～50 μ m, the surface apertures that this medical sponge dressing is less can effectively intercept antibacterial and harmful particle, can prevent wounded tissue bonding simultaneously, avoids causing secondary insult; The aperture, inside that this medical sponge dressing is larger can make a large amount of absorbing wound exudates of medical sponge dressing, there is good absorbability and larger absorptive capacity, keep wound surface moisture state simultaneously, play the effect of " moistening healing ", promote the healing of wound.
The present invention has measured the Balance Absorption rate in the present embodiment makes under 37 ℃ of conditions the medical sponge dressing acetic acid-sodium-acetate buffer at pH=5.5, and result shows, the equilibrium water absorption of this medical sponge dressing can reach more than 90%, has stronger absorbent.
The present invention has also tested this medical sponge dressing to staphylococcus aureus and colibacillary bacteriostatic experiment, Fig. 3 is the bacteriostatic experiment of this medical sponge dressing to staphylococcus aureus, Fig. 3 a is blank group (not adding medical sponge dressing), Fig. 3 b is experimental group (the medical sponge dressing that adds the present embodiment), Fig. 4 is that this medical sponge dressing is to colibacillary bacteriostatic experiment, Fig. 4 a is blank group (not adding medical sponge dressing), Fig. 4 b is experimental group (the medical sponge dressing that adds the present embodiment), as can be seen from the figure, the medical sponge dressing that the present embodiment makes is all fine to staphylococcus aureus and colibacillary fungistatic effect, as calculated, this sponge sample all can reach more than 99% to the antibacterial effect of escherichia coli and gold-coloured staphylococci, there is very strong antibacterial effect, be suitable as the dressing of infective wound surface.
Embodiment bis-
(1) aloe frozen-dried powder is dissolved in in distilled water, to obtain mass concentration be 2% aloe water solution, is placed in 4 ℃ of refrigerators and stores for future use;
(2) polyvinyl alcohol material that by molecular weight be 200,000, alcoholysis degree is 88% is dissolved in distilled water at 90 ℃, and to obtain mass concentration be 25% polyvinyl alcohol water solution;
(3) polyvinyl alcohol water solution that aloe water solution step (1) being obtained and step (2) obtain is mixed to get the first mixed solution, adds poly-own methylene hydrochloric acid in the first mixed solution, obtains the second mixed solution after stirring;
(4) the second mixed solution is injected to politef mould, the thickness of the second mixed solution in politef mould is 500 μ m, standing 4h at 4 ℃, subsequently at-20 ℃ of freezing 4h, again at 30 ℃ of 1h that thaw, repeated freezing thaws 6 times, obtain gel, by gel successively lyophilization, cut out packing, after Co 60 sterilizing, obtain medical sponge dressing, it is three-dimensional netted that polyvinyl alcohol is, Aloe and poly-own methylene hydrochloric acid are carried on the surperficial and inner of polyvinyl alcohol, polyvinyl alcohol, Aloe and poly-own methylene hydrochloric acid form the composite with micropore, polyvinyl alcohol, the quality of Aloe and poly-own methylene hydrochloric acid accounts for 79% of composite gross mass, 20% and 1%.
Embodiment tri-
(1) aloe frozen-dried powder is dissolved in in distilled water, to obtain mass concentration be 0.1% aloe water solution, is placed in 4 ℃ of refrigerators and stores for future use;
(2) polyvinyl alcohol that by molecular weight be 100,000, alcoholysis degree is 88% is dissolved in distilled water at 90 ℃, and to obtain mass concentration be 15% polyvinyl alcohol water solution;
(3) polyvinyl alcohol water solution that aloe water solution step (1) being obtained and step (2) obtain is mixed to get the first mixed solution, in the first mixed solution, adds hydroxypropyltrimethyl ammonium chloride chitosan, obtains the second mixed solution after stirring;
(4) the second mixed solution is injected to politef mould, the thickness of the second mixed solution in politef mould is 200 μ m, standing 8h at 4 ℃, subsequently at-60 ℃ of freezing 12h, again at 30 ℃ of 2h that thaw, repeated freezing thaws 4 times, obtain gel, by gel successively lyophilization, cut out packing, after Co 60 sterilizing, obtain medical sponge dressing, it is three-dimensional netted that polyvinyl alcohol is, Aloe and hydroxypropyltrimethyl ammonium chloride chitosan are carried on the surperficial and inner of polyvinyl alcohol, polyvinyl alcohol, Aloe and hydroxypropyltrimethyl ammonium chloride chitosan form the composite with micropore, polyvinyl alcohol, the quality of Aloe and hydroxypropyltrimethyl ammonium chloride chitosan accounts for 85% of composite gross mass, 14% and 1%.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a medical sponge dressing, it is characterized in that, described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on the surperficial and inner of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the quality of described polyvinyl alcohol, Aloe and antibacterial accounts for respectively 79%～94.5%, 5%～20% and 0.5%～1% of described composite gross mass.
2. medical sponge dressing as claimed in claim 1, is characterized in that, the micropore size of described composite material surface is 1 μ m～5 μ m.
3. medical sponge dressing as claimed in claim 1, is characterized in that, the micropore size of described composite inner is 20 μ m～50 μ m.
4. medical sponge dressing as claimed in claim 1, is characterized in that, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
5. a preparation method for medical sponge dressing, is characterized in that, comprises the following steps:
(1) will after aloe frozen-dried powder dissolving, obtain aloe water solution;
(2) will after polyvinyl alcohol material dissolving, obtain polyvinyl alcohol water solution;
(3) described aloe water solution and described polyvinyl alcohol water solution are mixed to get to the first mixed solution, then in described the first mixed solution, add antibacterial, after stirring, obtain the second mixed solution;
(4) described the second mixed solution is injected to mould, the thickness of described the second mixed solution in described mould is 50 μ m～500 μ m, standing 4～8h at 4 ℃, subsequently at-20 ℃～-80 ℃ freezing 4～24h, again at 20 ℃～30 ℃ 1～4h that thaw, repeated freezing and thawing 1～6 time, obtain gel, by described gel successively lyophilization, cut out after packing and sterilizing, obtain described medical sponge dressing, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on the surperficial and inner of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, described polyvinyl alcohol, the quality of Aloe and antibacterial accounts for respectively 79%～94.5% of described composite gross mass, 5%～20% and 0.5%～1%.
6. the preparation method of medical sponge dressing as claimed in claim 5, is characterized in that, the micropore size of described composite material surface is 1 μ m～5 μ m.
7. the preparation method of medical sponge dressing as claimed in claim 5, is characterized in that, the micropore size of described composite inner is 20 μ m～50 μ m.
8. the preparation method of medical sponge dressing as claimed in claim 5, is characterized in that, described antibacterial is poly-own methylene hydrochloric acid or chitosan quaternary ammonium salt derivatives.
9. the preparation method of medical sponge dressing as claimed in claim 5, is characterized in that, described in step (1), in aloe water solution, the mass concentration of Aloe is 0.1%～2%.
10. the preparation method of medical sponge dressing as claimed in claim 5, is characterized in that, described in step (2), in polyvinyl alcohol water solution, the mass concentration of polyvinyl alcohol is 10%～25%.
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| CN105597136A (en) * | 2016-02-01 | 2016-05-25 | 上海昌颌医药科技有限公司 | Moisture-transfer and fast drying wound dressing |
| GB2537337A (en) * | 2014-10-14 | 2016-10-19 | Hero Healthcare Ltd | Bandage |
| CN106521697A (en) * | 2016-11-17 | 2017-03-22 | 无锡明盛纺织机械有限公司 | Carboxyethyl chitosan and polyvinyl alcohol composite fiber and preparation method and application thereof |
| CN108310475A (en) * | 2018-01-08 | 2018-07-24 | 广州润虹医药科技股份有限公司 | A kind of anti-clogging sucked type negative pressure drainage device |
| CN108498852A (en) * | 2018-04-24 | 2018-09-07 | 万绵水 | Ag/SiO2The wound dressing and preparation method thereof of hydrogel composite sponge |
| CN109568650A (en) * | 2018-12-19 | 2019-04-05 | 广州润虹医药科技股份有限公司 | A kind of chitosan quaternary ammonium salt antiseptic dressing and preparation method thereof |
| CN111249179A (en) * | 2020-03-18 | 2020-06-09 | 成都斯瑞宁科技有限公司 | Mask with medical function |
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| CN113181422A (en) * | 2021-05-18 | 2021-07-30 | 四川轻化工大学 | Antibacterial nontoxic hydrogel dressing and preparation method thereof |
| CN114106400A (en) * | 2021-12-02 | 2022-03-01 | 江西省科学院应用化学研究所 | Aziridine crosslinked N-halamine type antibacterial PVA sponge as well as preparation method and application thereof |
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