CN101244286A - Hydrogel dressings and preparation thereof - Google Patents
Hydrogel dressings and preparation thereof Download PDFInfo
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- CN101244286A CN101244286A CNA200710037471XA CN200710037471A CN101244286A CN 101244286 A CN101244286 A CN 101244286A CN A200710037471X A CNA200710037471X A CN A200710037471XA CN 200710037471 A CN200710037471 A CN 200710037471A CN 101244286 A CN101244286 A CN 101244286A
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Abstract
The invention discloses a hydrogel dressing, comprising water-soluble polymer, water-soluble chitin derivatives and solvent. The invention also discloses the method for preparing the hydrogel dressing, which is as follow: firstly, irradiation, secondly, circulation of freezing and unfreezing. The hydrogel dressing has the advantages of high transparency, large swelling capacity, high strength, low water evaporation rate, functions of antibacterial, anti-inflaminatory, hemostasis and promoting wound healing, no additive, and ability of providing a good healing environment for wound. The preparation method has the advantages of simple method, less time consumption, high efficiency, and ability of preparing the hydrogel dressing with high transparency, large swelling capacity and high strength.
Description
Technical field
The present invention relates to a kind of aerogel dressing that is applicable to burn, scald and traumatic wounds use and preparation method thereof.
Background technology
For a long time, people are generally the definition of medical dressing: in order to gauze, meche, cotton ball and the cotton general name of filling up of cleaning and protection wound.The main effect of the dressing on this traditional definition is to protect wound in wound healing process, but the healing of wound is not almost had facilitation.
Britain scientist George doctor Winter found in 1962, and moist environment helps wound healing.Since then, obtained development widely based on the various new-type dressing of this thought, as hydrocolloid dressing, aerogel dressing etc.Aerogel dressing has obviously alleviating pain, absorbs a large amount of wound effluent, and air permeable humidity retaining can not destroy the wound tissue of having healed when change dressings more, and the transparent advantages such as healing state that can observe wound, obtains the generally attention of various countries.
The main preparation methods of aerogel dressing has chemical method, radiation method and freeze-thaw method etc.Usually understand harmful small-molecule substances such as required cross-linking agent of residual reaction process and initiator in the hydrogel of chemical method preparation, influence its use.Radiation method causes the crosslinked aerogel dressing that makes by high-energy radiation, and its process need not added harmful substances such as any chemical cross-linking agent and initiator, and product is pure; Radiation can at room temperature be carried out, the reaction condition gentleness, and can be by the control radiation dose, control such as close rate properties of product; Gel formation can carry out simultaneously with sterilization simultaneously.Have on the document at present much about preparing the report of hydrogel with radiation method, but mechanical strength is less generally speaking for the hydrogel of radiation method preparation, and its application is restricted.Freeze-thaw method is a kind of very effective method of being reported the earliest by Peppas for preparing polyvinyl alcohol (PVA) hydrogel.The hydrogel that this method makes has advantages such as good springiness and mechanical strength be big, but this hydrogel is a kind of physical gel, can melt into solution when higher temperature; And the swellbility of hydrogel is less and opaque, influences in the therapeutic process observation to wound.The freezing thawing time of reporting in the document is 8～24h usually, and manufacturing cycle is long, is unfavorable for the production of product.
Synthetic polymer and natural polymer are the materials of present modal preparation hydrogel.Wherein, polyvinyl alcohol (PVA) has good biocompatibility, biological degradability and film property, and low price, is the most frequently used hydrogel substrate, but has only the hydrogel of polyvinyl alcohol, and toughness is relatively poor, and swellability is little, and performance is single; Chitin and chitosan are because its biocompatibility, biological degradability, antibiotic property and to the facilitation of wound healing are widely used in wound dressing; But chitin is difficult in water-soluble and other solvents, and chitosan can only be dissolved in diluted acid and some specific solvent, thereby has limited their application.
Aerogel dressing of the prior art generally need add various additives, and the use of additive can bring certain side effect usually.
Chinese patent CN 1579559A discloses polyvinyl alcohol hydrogel wound dressing of a kind of pastille, chitosan and preparation method thereof.Contain chitosan in its prescription, but chitosan is water insoluble, and is dissolved in dilute acid soln, thus in preparation process, need the acid neutralization, otherwise dressing has stimulation to wound; This aerogel dressing also contains additives such as wetting agent, plasticizer, and these additives are easy to separate out in the use of dressing, and wound is had certain side effect; If its some antiinflammatory of used drug main, antibacterials do not promote the function of wound healing; Circulating freezing resistance step in its preparation method, the time is longer, and the freezing and thawing time all needs 8～30 hours, influences its production efficiency.
Summary of the invention
The objective of the invention is to disclose the aerogel dressing that a kind of water content height, good water-retaining property, intensity height, transparency height, good permeability, water evaporation rate are low, antibiotic, have advantages such as antiinflammatory, hemostasis and promotion wound healing.
Aerogel dressing of the present invention contains water-soluble polymer and water-solubility chitin derivative, and surplus is a solvent.
Among the present invention, described water-soluble polymer can select for use this area to use water-soluble polymer always, as polyvinyl alcohol, polyvinyl pyrrolidone, poly(ethylene oxide) etc.; Wherein, the preferable polyvinyl alcohol or the mixture of polyvinyl alcohol and agar of being selected from; What the content of water-soluble polymer was preferable is mass percent 5～15%; Described water-solubility chitin derivative is preferable is selected from water-soluble chitosan and/or carboxymethyl chitin; The content of water-solubility chitin derivative preferable for mass percent be 0.5～5%; Described solvent can be selected distilled water or normal saline etc. for use.
Aerogel dressing of the present invention also can further contain medicine.Described medicine can be anti-microbial type, various skin wounds such as hemostasis class.Wherein, preferable for having the medicine that promotes wound healing function and antiinflammation, as in Yunnan BAIYAO, the soft cream in sharp Pu and the antibiotic medicine dexamethasone one or more.What content of medicines was preferable is mass percent 0.001～5%.In this area, aerogel dressing Chinese medicine content refers to that the gel Chinese medicine accounts for the mass percent of solution state material in the gel, does not consider the dry weight of gel itself.
Another object of the present invention is to disclose a kind of convenient effective method for preparing aerogel dressing of the present invention, it combines irradiation method and freeze-thaw method, specifically comprise the steps: and to contain the solution of described water-soluble polymer and water-solubility chitin derivative, after deaeration is handled, use high-energy ray irradiation; Carry out circulating frozen again and melt processing, get final product; Step behind the irradiation is carried out under aseptic condition.
Among the present invention, the described solution that contains solid polymer and chitin derivativ can be made by following method: water-soluble polymer is dissolved in solvent, concentration can be mass percent 6～17%, be back to the uniform solution A of formation at 95 ℃ of following constant temperature, water-solubility chitin derivative is dissolved in the solvent, concentration can be mass percent 2～14%, is solution B again, solution A and B are mixed, and stirring gets final product.Solution A and B solvent for use can be distilled water.
Among the present invention, described deaeration is handled preferable employing ultrasonic method or settled process and is carried out; Described high-energy ray can be selected for use
60Co gamma-radiation or high-power electron beam ray; When being
60During the Co gamma-radiation, irradiation carries out in the airtight environment of anaerobic, and before and after in the irradiation process inverting container so that irradiation dose is even; When being high-energy electron beam irradiation, can directly the container that fills solution be put into irradiation under the electron beam, need not oxygen-free environment; That the dosage of irradiation is preferable is 10-70kGy.
Among the present invention, described circulating frozen melts the preferable parameter of handling and is: cryogenic temperature is-30～-18 ℃, and the time is 0.5～7 hour; Melt temperature is 20～40 ℃, and the time is 0.5～7 hour.What the number of times that the circulating frozen thawing is handled was preferable is 1～6 time.
Among the present invention, when preparation contains the aerogel dressing of the medicine that promotes wound healing, after circulating frozen melts processing, carry out processed, the solution (concentration can be mass percent 0.001～5%) that reuse contains described medicine carries out swelling, gets final product.The method of described processed can be selected vacuum freeze-drying method, boulton process or drying at room temperature method for use, and be 4～72 hours drying time; What described swelling time was preferable is 4～72 hours.The solution that contains medicine can be distilled water or the normal saline solution that contains medicine.After the swelling, can wipe the aerogel dressing surface solution, sealing, cryopreservation.
Positive progressive effect of the present invention is:
(1) used water-solubility chitin derivative (as water-soluble chitosan and carboxymethyl chitin) is the natural Biodegradable macromolecular material of a class in the aerogel dressing of the present invention.It is soluble in water, also has antibacterial anti hemorrhagic, promotes the function of cell regeneration.Be introduced in the aerogel dressing, need do not use other solvents (containing sour solvent), made things convenient for the aerogel dressing preparation process, avoided the stimulation of other solvents, and can effectively promote wound healing wound as irritating.
(2) aerogel dressing of the present invention can add medicine, as effective medicine that promotes wound healing and antiinflammatory such as Yunnan BAIYAO, the soft cream in sharp Pu and antibiotic medicine dexamethasone, makes hydrogel have functions such as good blood coagulation, antiinflammatory and promotion wound healing; Simultaneously, the water absorption that hydrogel itself is had, water-retaining property, breathability, pliability reach the slow release property to medicine, can guarantee that wound has the healing environment an of the best.Contain medicine in the dressing, drug slow is discharged, make the drug effect cycle longer, and help reducing the anaphylaxis of medicine.
(3) aerogel dressing of the present invention does not contain the easily additives such as plasticizer, wetting agent of stripping such as glycerol, Polyethylene Glycol, has avoided the toxic and side effects of additive, has improved its biocompatibility.
(4) in the preparation method of aerogel dressing of the present invention, used freezing thawing time of frozen-thaw process is few, has shortened preparation time greatly, has effectively improved preparation efficiency; Simultaneously, the preparation method of freeze thawing makes intensity height, transparency height, rate-of-loss of coolant, the low swellbility of hydrogel big behind the first irradiation.
Agents useful for same of the present invention and raw material are all commercially available to be got.
Description of drawings
Fig. 1 is the springform spirogram of the aerogel dressing of 4 kinds of distinct methods preparations among the effect embodiment.
Fig. 2 is the saturated swellbility figure of the aerogel dressing of 4 kinds of distinct methods preparations among the effect embodiment.
Fig. 3 is the dehydrating speed variation relation figure of the aerogel dressing of 4 kinds of distinct methods preparations among the effect embodiment.
Fig. 4 is the photo comparison diagram of the aerogel dressing of 4 kinds of distinct methods preparations among the effect embodiment.
In Fig. 1～4, Irra. is irradiation 30kGy; Irra.+FT is freeze thawing 3 times behind the irradiation 30kGy; FT is freeze thawing 3 times; FT+Irra. be irradiation 30kGy after the freeze thawing 3 times.
The specific embodiment
Mode below by embodiment further specifies the present invention, but does not therefore limit the present invention among the described scope of embodiments.
Embodiment 1
Polyvinyl alcohol 5g is dissolved in the 50g distilled water, and wiring solution-forming A is dissolved in the 40g distilled water with the 5g water-soluble chitosan simultaneously, and wiring solution-forming B mixes A and B, stirs, and ultrasonic going poured in the container behind the bubble, puts into the hermetic container that is full of nitrogen, uses
60Co gamma-radiation irradiation 10kGy, upset therebetween makes its irradiation even, takes out afterwards, under aseptic condition, puts into circulating frozen machine circulating frozen-thawing 4 times, and cryogenic temperature is-20 ℃, and the time is 1 hour, and melt temperature is a room temperature, the time is 0.5 hour; With the vacuum lyophilization 24 hours under aseptic condition of the hydrogel that makes, under aseptic condition, it is joined afterwards in the YUNNAN BAIYAO aqueous solution of 5wt%, soaked 24 hours, take out sealing, cryopreservation.Prepared hydrogel component is: 5wt%PVA, 5wt% water-soluble chitosan, the YUNNAN BAIYAO of 5wt%.
Embodiment 2
Polyvinyl alcohol 13g and agar 2g are dissolved in the 75g distilled water, and wiring solution-forming A is dissolved in the 9g distilled water with the 1g water-soluble chitosan simultaneously, wiring solution-forming B mixes A and B, stirs, pour in the container after leaving standstill bubble, with high-power electron beam x ray irradiation x 70kGy, take out, put into circulating frozen machine circulating frozen-thawing under the aseptic condition 1 time, cryogenic temperature is-30 ℃, time is 7 hours, and melt temperature is 40 ℃, and the time is 7 hours; With the hydrogel that makes dry 4 hours of vacuum drying oven under aseptic condition, under aseptic condition, it is joined afterwards in the YUNNAN BAIYAO aqueous solution of 3wt%, soaked 4 hours, take out and seal cryopreservation.Prepared hydrogel component is: 13wt%PVA, 2wt% agar, 1wt% water-soluble chitosan and 3wt% YUNNAN BAIYAO.
Polyvinyl alcohol 8.5g is dissolved in the 63g distilled water, and wiring solution-forming A is dissolved in the 28g distilled water with the 0.5g water-soluble chitosan simultaneously, wiring solution-forming B mixes A and B, stirs, ultrasonic going poured in the container behind the bubble, with high-power electron beam x ray irradiation x 50kGy, take out circulating frozen under the aseptic condition-thawing 3 times under the room temperature, cryogenic temperature is-18 ℃, time is 5 hours, and melt temperature is 30 ℃, and the time is 1.5 hours; With the hydrogel that makes drying at room temperature 72 hours under aseptic condition, under aseptic condition, it is joined afterwards in the dexamethasone aqueous solution of 1wt%, soaked 72 hours, take out sealing, cryopreservation.Prepared hydrogel component is: 8.5wt%PVA, 0.5wt% water-soluble chitosan, 1wt% dexamethasone.
Embodiment 4
Polyvinyl alcohol 9g is dissolved in the 70g distilled water, and wiring solution-forming A is dissolved in the 19g distilled water with the 2g carboxymethyl chitin simultaneously, and wiring solution-forming B mixes A and B, stirs, and ultrasonic going poured in the container behind the bubble, puts into the hermetic container that is full of nitrogen, uses
60Co gamma-radiation irradiation 30kGy, before and after inverting container so that irradiation dose is even, afterwards under the aseptic condition in the circulating frozen machine circulating frozen-thawing 6 times, cryogenic temperature is-20 ℃, time is 0.5 hour, melt temperature is 20 ℃, and the time is 4 hours, again the hydrogel that makes is put into vacuum desiccator lyophilization 48 hours under aseptic condition, under aseptic condition, it is joined afterwards in the normal saline solution of Li Pusong of 0.001wt%, soaked 48 hours, and took out sealing, cryopreservation.Prepared hydrogel component is: 9wt%PVA, 2wt% carboxymethyl chitin, 0.001wt% Li Pusong.
Embodiment 5
Polyvinyl alcohol 9g is dissolved in the 70g distilled water, and wiring solution-forming A is dissolved in the 19g distilled water with the 2g carboxymethyl chitin simultaneously, and wiring solution-forming B mixes A and B, stirs, and ultrasonic going poured in the container behind the bubble, puts into the hermetic container that is full of nitrogen, uses under the room temperature
60Co gamma-radiation irradiation 30kGy, front and back inverting container be so that irradiation dose is even, afterwards under the aseptic condition in the circulating frozen machine circulating frozen-thawing 6 times, cryogenic temperature is-20 ℃, and the time is 1 hour, and melt temperature is a room temperature, time is 4 hours, promptly makes aerogel dressing.Prepared hydrogel component is: 9wt%PVA, 2wt% carboxymethyl chitin.
Effect embodiment
(1) preparation of hydrogel
The 6g polyvinyl alcohol is dissolved in wiring solution-forming A in the 63g distilled water, simultaneously the 3g water-soluble chitosan is dissolved in the 28g distilled water, wiring solution-forming B, A and B are mixed, stir, ultrasonic going poured in the container behind the bubble, put into the hermetic container that is full of nitrogen, use gamma-ray irradiation 30kGy, afterwards under the aseptic condition in the circulating frozen machine circulating frozen-thawing 3 times, cryogenic temperature is-18 ℃, time is 1.5 hours, melt temperature is a room temperature, and the time is 1 hour, again the hydrogel that makes is put into vacuum desiccator lyophilization 2 days under aseptic condition, under aseptic condition, it is joined afterwards in the distilled water solution of YUNNAN BAIYAO of 2wt%, soaked 1 day, and took out sealing, cryopreservation.Consisting of of hydrogel: 3wt% water-soluble chitosan, 6wt% polyvinyl alcohol, 2wt% YUNNAN BAIYAO.
Adopt above-mentioned identical proportioning to prepare aerogel dressing, preparation method adopts 30kGy's
60Co gamma-radiation radiation method, circulating frozen melts 3 methods, reaches first circulating frozen and melts the method for irradiation 30kGy again 3 times, and all the other parameters are the same.
(2) test of hydrogel performance
The aerogel dressing that above-mentioned four kinds of methods are made carries out performance test:
(a) intensity of the elastic modelling quantity of hydrogel-reaction water gel
Test condition: 25 ℃, strain is 0.2%, and shearing frequency is 1rad/s.
(b) swelling behavior degree
Test condition: 37 ℃ of temperature, swellbility=W
s/ W
d
W
sWeight when-hydrogel reaches swelling equilibrium; W
dThe weight of-dried hydrogel.
(c) the water evaporation rate of hydrogel
Test condition: the hydrogel that reaches swelling equilibrium is put into 37 ℃ incubator, measures the weight of its hydrogel at regular intervals.
Percentage of water loss (%)=(W
s-W
t)/(W
s-W
d) * 100
W
sThe weight of-swelling hydrogel, W
tThe swelling hydrogel is put into the weight of incubator t during the time, W
dThe weight of hydrogel bone dry in incubator.
(3) the results are shown in Figure of description, the meaning that identifies among the figure is as follows:
Irra.-irradiation 30kGy; Freeze thawing is 3 times behind the Irra.+FT-irradiation 30kGy;
FT-freeze thawing 3 times; Irradiation 30kGy after the FT+Irra.-freeze thawing 3 times.
As seen from Figure 1, the aerogel dressing that the aerogel dressing elastic modelling quantity that adopts preparation method of the present invention (freeze thawing is 3 times behind the Irra.+FT-irradiation 30kGy) to make makes apparently higher than additive method illustrates that promptly the aerogel dressing that the inventive method makes has higher intensity; It can also be seen that simultaneously the hydrogel intensity of radiation method (Irra.) preparation is very little, can not be used for aerogel dressing.
As seen from Figure 2, adopt preparation method of the present invention (freeze thawing is 3 times behind the Irra.+FT-irradiation 30kGy) though the preparation its swellbility of hydrogel less than radiation method, but all greater than other two kinds of methods, radiation method (Irra.) is though the hydrogel swellbility of preparation is big, but because its intensity is very little, can not be used for wound dressing, illustrate that promptly the aerogel dressing of the inventive method preparation has the performance that absorbs a large amount of wound fluids.
As seen from Figure 3, adopt the water evaporation rate of hydrogel of preparation method of the present invention (freeze thawing is 3 times behind the Irra.+FT-irradiation 30kGy) preparation obviously slow, illustrate that promptly the aerogel dressing that the present invention prepares has better water retention property than radiation method (FT+Irra.) after freeze-thaw method (FT), the freeze thawing.
As seen from Figure 4, the transparency of hydrogel that adopts preparation method of the present invention (freeze thawing is 3 times behind the Irra.+FT-irradiation 30kGy) preparation illustrates promptly that obviously than radiation method (FT+Irra.) height after freeze-thaw method (FT), the freeze thawing aerogel dressing that the present invention prepares has higher transparency.
Claims (14)
1. an aerogel dressing contains water-soluble polymer, and surplus is a solvent, it is characterized in that: also contain water-solubility chitin derivative.
2. aerogel dressing as claimed in claim 1 is characterized in that: described water-soluble polymer is a polyvinyl alcohol, or the mixture of polyvinyl alcohol and agar.
3. aerogel dressing as claimed in claim 1 is characterized in that: the content of described water-soluble polymer is mass percent 5～15%.
4. aerogel dressing as claimed in claim 1 is characterized in that: described water-solubility chitin derivative is water-soluble chitosan and/or carboxymethyl chitin.
5. aerogel dressing as claimed in claim 1 is characterized in that: the content of described water-solubility chitin derivative is that mass percent is 0.5～5%.
6. aerogel dressing as claimed in claim 1 is characterized in that: described aerogel dressing also contains medicine.
7. aerogel dressing as claimed in claim 6 is characterized in that: described medicine is selected from one or more in YUNNAN BAIYAO, the soft cream in sharp Pu and the antibiotic medicine dexamethasone.
8. aerogel dressing as claimed in claim 6 is characterized in that: described content of medicines is a mass percent 0.001～5%.
9. the preparation method of aerogel dressing as claimed in claim 1 is characterized in that comprising the steps: and will contain the solution of described water-soluble polymer and water-solubility chitin derivative, after deaeration is handled, uses high-energy ray irradiation; Carry out circulating frozen again and melt processing, get final product; Step behind the irradiation is carried out under aseptic condition.
10. method as claimed in claim 9 is characterized in that: described high-energy ray is
60Co gamma-radiation or high-power electron beam ray; When being
60During the Co gamma-radiation, irradiation carries out in the airtight environment of anaerobic, and before and after in the irradiation process upset solution so that irradiation dose is even.
11. method as claimed in claim 9 is characterized in that: the dosage of described irradiation is 10-70kGy.
12. method as claimed in claim 9 is characterized in that: it is-30～-18 ℃ that described circulating frozen melts the cryogenic temperature of handling, and the time is 0.5～7 hour; Melt temperature is 20-40 ℃, and the time is 0.5～7 hour; It is 1～6 time that circulating frozen melts the number of times of handling.
13. method as claimed in claim 9 is characterized in that: circulating frozen carries out processed after melting processing again, and the solution that reuse contains described medicine carries out swelling, gets final product.
14. method as claimed in claim 13 is characterized in that: the method for described processed is vacuum freeze-drying method, vacuum drying oven seasoning or drying at room temperature method, and be 4～72 hours drying time; Described swelling time is 4～72 hours.
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|---|---|---|---|
| CNA200710037471XA CN101244286A (en) | 2007-02-13 | 2007-02-13 | Hydrogel dressings and preparation thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804218A (en) * | 2010-04-13 | 2010-08-18 | 王艳 | Human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN102711850A (en) * | 2010-01-14 | 2012-10-03 | 于尔戈实验室 | Novel bandage including a web of microfibres or nanofibres suitable for gelling or solubilising |
| CN102711851A (en) * | 2010-01-14 | 2012-10-03 | 于尔戈实验室 | Novel bandage including agglomerates of particles suitable for rapidly gelling or solubilising |
| CN104324413A (en) * | 2014-11-10 | 2015-02-04 | 华玉叶 | Preparation method of hydrogel dressing |
| CN106421886A (en) * | 2016-08-17 | 2017-02-22 | 倪娟形 | Hydrogel dressing for repairing wounds and preparation method of hydrogel dressing |
| CN109045349A (en) * | 2018-09-27 | 2018-12-21 | 四川省原子能研究院 | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes |
| CN111138692A (en) * | 2019-12-25 | 2020-05-12 | 中广核达胜加速器技术有限公司 | Irradiation treatment method for liquid glue |
-
2007
- 2007-02-13 CN CNA200710037471XA patent/CN101244286A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102711850A (en) * | 2010-01-14 | 2012-10-03 | 于尔戈实验室 | Novel bandage including a web of microfibres or nanofibres suitable for gelling or solubilising |
| CN102711851A (en) * | 2010-01-14 | 2012-10-03 | 于尔戈实验室 | Novel bandage including agglomerates of particles suitable for rapidly gelling or solubilising |
| CN102711851B (en) * | 2010-01-14 | 2015-04-01 | 于尔戈实验室 | Novel wound dressing including agglomerates of particles suitable for rapidly gelling or solubilising |
| CN102711850B (en) * | 2010-01-14 | 2015-04-01 | 于尔戈实验室 | Novel bandage including a web of microfibres or nanofibres suitable for gelling or solubilising |
| CN101804218A (en) * | 2010-04-13 | 2010-08-18 | 王艳 | Human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN102335451B (en) * | 2011-09-15 | 2014-04-09 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN104324413A (en) * | 2014-11-10 | 2015-02-04 | 华玉叶 | Preparation method of hydrogel dressing |
| CN106421886A (en) * | 2016-08-17 | 2017-02-22 | 倪娟形 | Hydrogel dressing for repairing wounds and preparation method of hydrogel dressing |
| CN109045349A (en) * | 2018-09-27 | 2018-12-21 | 四川省原子能研究院 | A kind of hydrogel skin wound dressing and preparation method thereof that antibacterial heal-promoting closes |
| CN111138692A (en) * | 2019-12-25 | 2020-05-12 | 中广核达胜加速器技术有限公司 | Irradiation treatment method for liquid glue |
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