CN103463669A - Liquid wound dressing and preparation method thereof - Google Patents
Liquid wound dressing and preparation method thereof Download PDFInfo
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- CN103463669A CN103463669A CN2013104212086A CN201310421208A CN103463669A CN 103463669 A CN103463669 A CN 103463669A CN 2013104212086 A CN2013104212086 A CN 2013104212086A CN 201310421208 A CN201310421208 A CN 201310421208A CN 103463669 A CN103463669 A CN 103463669A
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Abstract
The invention discloses a liquid wound dressing which is characterized by comprising the following raw materials in parts by weight: 100-180 parts of a medical polymer film forming material, 0-20 parts of chitosan, 10-25 parts of polyethylene glycol 400 and 10-28 parts of glycerin, wherein the medical polymer film forming material is one in polyvinyl alcohol and polyvinyl butyral or a mixture of carbomer and one in the polyvinyl alcohol and the polyvinyl butyral. The liquid wound dressing can absorb the wound exudate, can effectively debride, maintains the surface of a wound to be wet, promotes the wound healing and is good in sterilizing effect.
Description
Technical field
The present invention relates to a kind of liquid Wound dressing and preparation method thereof, belong to medical technical field.
Background technology
Skin is the organ of human body maximum, is also one of most important organ, has the external microbe of resisting invasion, drains and prevent moisture evaporation, regulate body temperature, maintains the important function such as organismic internal environment is stable.Simultaneously, skin is also that human body the most easily is subject to the various factors impact and traumatogenic main organ.Investigation shows, knife injury in daily life, scald, knock damage etc. are skin injury on a small scale, become one of most important factor of harm compatriots health, in whole 1.2 ten thousand interviewees, 78.7% people means, oneself once was subject to this type of skin injury, and wherein, therefore the wounded of 45.9% stays cicatrix.The wound surface that skin trauma causes, easily cause bleeding on the one hand, oozing of blood etc., causes patient's fear, increase its psychological burden, and wound surface contacts work and the life that the pain caused can have a strong impact on the patient with the external world; On the other hand, if deal with improperly, can cause that the pathogenic microorganism growth causes infection, bring various complication, severe patient is threat to life even.Therefore, to effective nursing of skin wound, be the important content of field of medicaments research.
20 th America Johson & Johnson take the lead in releasing adhesive bandage, and through nearly centenary development, the adhesive bandage of various forms specification is applied.The advantages such as adhesive bandage can hemostasis by compression, protection wound surface, prevention infection, promotion healing, volume is little, easy to use and carry, curative effect is reliable.Even to this day, adhesive bandage is still being brought into play powerful effect.But adhesive bandage has fixed dimension, wound surface to different area and character is used inconvenience, its external adhesive plaster breathability is poor, the normocrinic steam of body local and perspiration can not penetrate this layer of adhesive plaster, can produce action of soaking to local skin, in addition, the adhesive bandage water resistance is poor, and affects patient's orthobiosis after using.Therefore, over nearly 40 years, Novel wound dressing develops rapidly, and replaces adhesive bandage gradually, and particularly in developed country and areas such as America and Europes, Novel wound dressing is comparatively universal, becomes the first-selection of wound surface nursing.The Novel wound dressing of current clinical use mainly contains following a few class:
1, polyurethane foam and thin film
Polyurethane has good elasticity, has cavity and very large water absorption is arranged in the structure of foam state, can be used as directly contacting the material of wound.Lamellar and spherical two kinds are arranged on market, and lamellar can be used for showing shallow wound surface, spherically can be used for having dead space and empty wound.This type of dressing is used the effect that suppresses granulation tissue hyperplasia is arranged in conjunction with Elastic bandage.The dressing of thin film class mainly is comprised of polyurethane material and the medical viscose glue of desensitization.This type of dressing does not have absorbent properties, is unsuitable for the many wound surface of sepage, and this type of dressing mainly plays the effect of physical isolation, and bacteriostasis property is poor.
2, alginic acid fibre dressing
Such dressing main component is taken from the algae in sea water, utilizes the undissolvable polysaccharide alginate of the like fibrous element in algae to make dressing.Its main feature is high-hygroscopicity, one-tenth colloidality and hemostasis.Such dressing has part debridement effect, owing to containing a large amount of calcium ions, slight anastalsis is arranged simultaneously.The major defect of such dressing is that simple alginic acid dressing can not be for infective wound surface.
3, water gel dressing
Water gel is the macromolecule network of a kind of swelling in water or physiological fluid.The Main Function of such dressing is autologous debridement, and mechanism of action is in the moistening environment, to rely on the collagen protein digestive enzyme in wound self transudate to decompose downright bad material.Such dressing needs second layer dressing to be fixed while using, and the hemostasis antiphlogistic effects is poor.
4, hydrocolloid class dressing
Such dressing is to be mixed and processed by the granule of water-soluble high-molecular substance and rubber goo, and modal gel is carboxymethyl cellulose.Try out in few wound to middle isotonic solution amount, maintain the moist environment of wound surface.The debridement effect can be effectively brought into play in such dressing, toughness, and highly airtight wound surface, can cut randomly according to the shape of wound, easy to use.Major defect is while being applied to the wound of a large amount of transudates, often need more change dressings, otherwise transudate leaks outside.In addition, dressing itself has abnormal flavour and presents pus sample outward appearance, is difficult to be accepted by the patient.
Summary of the invention
Goal of the invention of the present invention is: for the problem of above-mentioned existence, provide a kind of liquid Wound dressing, can absorb the wound surface exudate, effectively debridement keeps wound surface moistening simultaneously, promotes wound healing, and bactericidal effect is good.Another object of the present invention is to provide the preparation method of this kind of liquid Wound dressing
Technical scheme of the present invention is as follows: a kind of liquid Wound dressing is characterized in that: mainly the following raw material by parts by weight makes: medical high polymer filmogen 100-180 part, chitosan 0-20 part, PEG400 10-25 part, glycerol 10-28 part; The mixture that wherein the medical high polymer filmogen is wherein a kind of and carbomer in wherein a kind of or polyvinyl alcohol and the polyvinyl butyral resin in polyvinyl alcohol and polyvinyl butyral resin.
In technique scheme: the mixture that described medical high polymer filmogen is wherein a kind of and carbomer in polyvinyl alcohol and polyvinyl butyral resin, described carbomer is 10-30 part according to the mass fraction, polyvinyl alcohol or polyvinyl butyral resin 100-150 part.
In technique scheme: described medical high polymer filmogen is polyvinyl alcohol or the polyvinyl butyral resin that mass fraction is 100-150 part.
In technique scheme: also comprise solvent, described solvent is ethanol or ethanol and the mixing of deionized water.The total amount of described solvent is 800-1000 part.
Carbomer is a kind of by acrylic acid and acrylic sucrose or the crosslinked high molecular polymer formed of acrylic tetramethylolmethane, by U.S. Goodrich company, is produced the earliest.Carbomer forms clear and bright solution when low concentration, forms translucent gel when concentration is larger.Carbomer has good thickening property, gelation, cohesive, emulsibility, suspension and film property.As filmogen, thickening agent, emulsifying agent in the medical industry extensive use.Using carbomer in the present invention is main filmogen and thickening agent, and the airborne polluter of film product energy physical isolation of making has good breathability simultaneously, the protection wound surface.
Polyvinyl alcohol is the unique high molecular weight water soluble polymer of occurring in nature, and its good hydrophilic property, source are abundant, cheap.Material prepared by polyvinyl alcohol has good water absorption and swelling, biological degradability.Can keep wound surface moistening, be conducive to epithelial growth and reparation, be a kind of good filmogen.Polyvinyl alcohol is as main filmogen, makes the product of the present invention can physical isolation wound surface and air, avoids wound surface by airborne various particles and microbial contamination.In addition, can keep wound surface moistening, contribute to wound surface to recover.
Polyvinyl butyral resin is the polymer with hexatomic ring ethylidene ether structure that in carbonyl in butyraldehyde and polyvinyl alcohol, adjacent two hydroxyl reactions generate.There is good pliability, cohesiveness and tolerance to cold.In fields such as coatings industry, typography, medical industries, be widely used.Polyvinyl butyral resin is good filmogen, and the film of formation has good ductility, water proofing property, pliability.
Chitosan is natural macromolecular chitin deacetylase product, it is glucose polymer, there is the premium properties such as good biological functionality and the compatibility, blood compatibility, safety, microbic resolvability, be widely used in the numerous areas such as medicine, food, chemical industry.Chitosan is good antibacterial, can suppress the growth and breeding of some funguses, antibacterial and virus.Think that at present its possible antibacterial mechanism comprises three aspects:: the one, due to the polycation of chitosan, easily with the group effect of fungal cell's surface band negative charge, thus mobility and the permeability of change pathogen cell membrane; The 2nd, disturb copying and transcribing of pathogen DNA; The 3rd, the metabolism of blocking-up pathogen.In recent years, research shows that chitosan is also by inducing pathogenesis-related proteins, and the modes such as accumulation secondary metabolite and signal conduction reach antibiotic purpose.In addition, chitosan promotes the effect of blood coagulation in addition, can be used as hemorrhage, also can be used for the Wound filling material, there is sterilizing, promote wound healing, absorb Wound exudate, keep wound moistening, be difficult for the effect such as syneresis.Chitosan is used widely in medical dressing.In the present invention, the main effect of chitosan comprises and absorbs Wound exudate and debridement, antibacterial, keep wound moistening and promote the effect such as wound healing.
Medical ethanol and deionized water are the solvent as membrane solvent and various other compositions in the present invention, and ethanol also has certain bacteriostasis.When product of the present invention, with after wound surface contacts, ethanol is due to its volatility volatilization within a short period of time, and product of the present invention is film forming rapidly, reaches and protects the wound effect.
PEG400 and glycerol mainly play in the present invention moisturizing, lubricate, increase the effect of product stickiness and adhesion.
Another object of the present invention is achieved in that a kind of preparation method of liquid Wound dressing, it is characterized in that: complete in accordance with the following steps:
(1), take chitosan 0-20 part, add 2% acetic acid solution, stirring and dissolving obtains chitosan solution;
(2), weighing polyvinyl alcohol or polyvinyl butyral 100-150 part adds deionized water or ethanol, stirring and dissolving obtains medical high polymer filmogen solution; When using polyvinyl alcohol, solvent can adopt the deionized water dissolving polyvinyl alcohol, adopts the anhydrous alcohol solution polyvinyl butyral resin while adopting polyvinyl butyral resin.
(3), the solution of step (1) and (2) is mixed, add 10-25 part PEG400, mix homogeneously, then add 10-28 glycerol, be uniformly mixed;
(4), in the solution of above-mentioned preparation, add ethanol, be uniformly mixed, sterilizing, make liquid Wound dressing of the present invention.
In technique scheme: described step also comprises in (2): take carbomer 10-30 part, add the ethanol stirring and dissolving to obtain carbomer solution.This preparation method is simple.
Beneficial effect: raw material of the present invention is originate abundant high molecular polymer (polyvinyl alcohol or polyvinyl butyral resin) and carbomer of occurring in nature, is equipped with chitosan and various adjuvant is made casting product of the present invention.Major advantage of the present invention is: (1) is used alcohol solvent, utilize the rapid boiling characteristics of ethanol, product of the present invention can be on wound surface fast filming, prevent that airborne pollutant from contacting wound surface and growing at wound surface with antibacterial, keep the wound surface anaerobic environment, suppress anaerobism pathogen growth and breeding, can effectively protect wound surface; (2) use the macromolecular materials such as polyvinyl alcohol and chitosan, can absorb the wound surface exudate, effectively debridement keeps wound surface moistening simultaneously, promotes wound healing; (3) chitosan is a kind of natural disinfection and antibacterial, can kill and suppress the pathogen of wound surface, guarantees the aseptic of wound surface, can react by inflammation-inhibiting simultaneously, promotes wound surface regeneration; (4) medical industry such as PEG400 and glycerol additive, the adhesive force of raising invention product and wound surface, contribute to Rehabilitation.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1
(1) take the 1g chitosan, add 2% acetic acid solution 10ml, stirring and dissolving, make solution I;
(2) weighing polyvinyl alcohol solid 12g, add the 30ml deionized water, is heated to 60 ℃, and stirring and dissolving, make solution II;
(3) solution I and solution II are mixed, add the 2g PEG400, mix homogeneously, then add 1.5g glycerol, be uniformly mixed;
(4) add ethanol in the solution of above-mentioned preparation, be settled to 100ml, mix homogeneously, used C
o 60irradiation sterilization 30 minutes, make liquid Wound dressing of the present invention.
According to document " foundation of repair in trauma animal model " [Yang Rui, Li Yajie. nursing research, 2003,17 (12A): 1369-1370] described method, take the SD rat as laboratory animal, set up skin line style incision model, with the dressing of " wound one brush obtains " wound liquid adhesive, (Tianjin one brush obtains the medical supplies company limited, production batch: in January, 2013) positive contrast, with the negative contrast of 0.9% normal saline, the prepared Wound dressing of the present embodiment of take is experimental group, tests Wound dressing of the present invention and protects the wound effect.12 of every group of laboratory animals, dosage is: each 1g, evenly smear to and cover wound fully, every 12h changes once, continuous use 14d.Result is: positive control film formation time 3-5min, experimental group film formation time 4-7min; With wound, without infecting, hardening without red and swollen, nothing, the wound well-grown is as qualitative evaluation wound healing index, after continuous use 14d, all groups are all without animal dead, negative control group wound healing rate is 28%, and positive controls wound healing rate is 83%, and experimental group wound healing rate is 91%.Wound dressing prepared by zoopery proof the present embodiment has good protecting wound surface effect.
Embodiment 2
(1) take the 2g chitosan, add 2% acetic acid solution 10ml, stirring and dissolving, make solution I;
(2) weighing polyvinyl alcohol solid 15g, add the 40ml deionized water, is heated to 60 ℃, and stirring and dissolving, make solution II;
(3) solution I and solution II are mixed, add the 1g PEG400, mix homogeneously, then add 2.8g glycerol, be uniformly mixed;
(4) add ethanol in the solution of above-mentioned preparation, be settled to 100ml, mix homogeneously, used C
o 60irradiation sterilization 30 minutes, make liquid Wound dressing of the present invention.
According to document " foundation of repair in trauma animal model " [Yang Rui, Li Yajie. nursing research, 2003,17 (12A): 1369-1370] described method, take the SD rat as laboratory animal, set up skin line style incision model, with the dressing of " wound one brush obtains " wound liquid adhesive, (Tianjin one brush obtains the medical supplies company limited, production batch: in January, 2013) positive contrast, with the negative contrast of 0.9% normal saline, the prepared Wound dressing of the present embodiment of take is experimental group, tests Wound dressing of the present invention and protects the wound effect.12 of every group of laboratory animals, dosage is: each 1g, evenly smear to and cover wound fully, every 12h changes once, continuous use 14d.Result is: positive control film formation time 3-5min, experimental group film formation time 4-7min; With wound, without infecting, hardening without red and swollen, nothing, the wound well-grown is as qualitative evaluation wound healing index, after continuous use 14d, all groups are all without animal dead, negative control group wound healing rate is 28%, and positive controls wound healing rate is 82%, and experimental group wound healing rate is 92.5%.Wound dressing prepared by zoopery proof the present embodiment has good protecting wound surface effect.
Embodiment 3
(1) take carbomer 2g, add ethanol 20ml, stirring and dissolving, make solution I;
(2) weighing polyvinyl alcohol butyral solid 10g, add 30ml ethanol, and stirring and dissolving, make solution II;
(3) solution I and solution II are mixed, add the 1g Polyethylene Glycol, then add 1.8g glycerol, be uniformly mixed;
(4) add ethanol in the solution of above-mentioned preparation, be settled to 100ml, mix homogeneously, used C
o 60irradiation sterilization 30 minutes, make liquid Wound dressing of the present invention.
According to the animal experiment method described in embodiment 1, tested, result is: positive control film formation time 3-5min, experimental group film formation time 3-5min; All animals are all without dead, and negative control wound healing rate is 33%, and positive control wound healing rate is 83%, and experimental group wound healing rate is 75%.Wound dressing prepared by zoopery proof the present embodiment has good protecting wound surface effect.
Embodiment 4
(1) take carbomer 3g, add ethanol 20ml, stirring and dissolving, make solution I;
(2) weighing polyvinyl alcohol butyral solid 15g, add 30ml ethanol, and stirring and dissolving, make solution II;
(3) solution I and solution II are mixed, add the 2.5g Polyethylene Glycol, then add 2.8g glycerol, be uniformly mixed;
(4) add ethanol in the solution of above-mentioned preparation, be settled to 100ml, mix homogeneously, used C
o 60irradiation sterilization 30 minutes, make liquid Wound dressing of the present invention.
According to the animal experiment method described in embodiment 1, tested, result is: positive control film formation time 3-5min, experimental group film formation time 3-5min; All animals are all without dead, and negative control wound healing rate is 33%, and positive control wound healing rate is 83%, and experimental group wound healing rate is 82%.Wound dressing prepared by zoopery proof the present embodiment has good protecting wound surface effect.
Embodiment 5
(1) take the 1.5g chitosan, add 2% acetic acid solution 10ml, stirring and dissolving, make solution I;
(2) weighing polyvinyl alcohol butyral solid 12g, add 30ml ethanol, and stirring and dissolving, make solution II;
(3) take carbomer 2g, add ethanol 20ml, stirring and dissolving, make solution III;
(4) solution I, solution II and solution III are mixed, add the 2g PEG400, mix homogeneously, then add 2g glycerol, be uniformly mixed;
(5) add ethanol in the solution of above-mentioned preparation, be settled to 100ml, mix homogeneously, used C
o 60irradiation sterilization 30 minutes, make liquid Wound dressing of the present invention.
According to the animal experiment method described in embodiment 1, tested, result is: positive control film formation time 3-5min, experimental group film formation time 3-5min; All animals are all without dead, and negative control wound healing rate is 28%, and positive control wound healing rate is 84%, and experimental group wound healing rate is 89%.Wound dressing prepared by zoopery proof the present embodiment has good protecting wound surface effect.
The present invention is not limited to the aforesaid specific embodiment.The present invention expands to any new feature or any new combination disclosed in this manual, and the arbitrary new method disclosed or step or any new combination of process.
Claims (7)
1. a liquid Wound dressing is characterized in that: mainly the following raw material by parts by weight makes: medical high polymer filmogen 100-180 part, chitosan 0-20 part, PEG400 10-25 part, glycerol 10-28 part; The mixture that wherein the medical high polymer filmogen is wherein a kind of and carbomer in wherein a kind of or polyvinyl alcohol and the polyvinyl butyral resin in polyvinyl alcohol and polyvinyl butyral resin.
2. liquid Wound dressing according to claim 1, it is characterized in that: the mixture that described medical high polymer filmogen is wherein a kind of and carbomer in polyvinyl alcohol and polyvinyl butyral resin, described carbomer is 10-30 part according to the mass fraction, polyvinyl alcohol or polyvinyl butyral resin 100-150 part.
3. liquid Wound dressing according to claim 1, it is characterized in that: described medical high polymer filmogen is polyvinyl alcohol or the polyvinyl butyral resin that mass fraction is 100-150 part.
4. liquid Wound dressing according to claim 1 is characterized in that: also comprise solvent, described solvent is ethanol or ethanol and the mixing of deionized water.
5. liquid Wound dressing according to claim 4.It is characterized in that: the total amount of described solvent is 800-1000 part.
6. the preparation method of a liquid Wound dressing is characterized in that: complete in accordance with the following steps:
(1), take chitosan 0-20 part, add 2% acetic acid solution, stirring and dissolving obtains chitosan solution;
(2), weighing polyvinyl alcohol or polyvinyl butyral 100-150 part adds deionized water or ethanol, stirring and dissolving obtains medical high polymer filmogen solution;
(3), the solution of step (1) and (2) is mixed, add 10-25 part PEG400, mix homogeneously, then add 10-28 part glycerol, be uniformly mixed;
(4), in the solution of above-mentioned preparation, add ethanol, be uniformly mixed, sterilizing, make liquid Wound dressing of the present invention.
7. the preparation method of liquid Wound dressing according to claim 6, it is characterized in that: described step also comprises in (2): take carbomer 10-30 part, add the ethanol stirring and dissolving to obtain carbomer solution.
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