CN111166929A - Wet wound dressing and preparation method thereof - Google Patents
Wet wound dressing and preparation method thereof Download PDFInfo
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- CN111166929A CN111166929A CN201811335546.7A CN201811335546A CN111166929A CN 111166929 A CN111166929 A CN 111166929A CN 201811335546 A CN201811335546 A CN 201811335546A CN 111166929 A CN111166929 A CN 111166929A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a wet wound dressing which comprises the following components in parts by weight: 120-160 parts of polyvinyl alcohol, 5-30 parts of chitosan, 10-20 parts of polyethylene glycol, 600-800 parts of ethanol, 10-20 parts of onion extract, 10-20 parts of asiatic pennywort herb extract, 5-15 parts of aloe extract, 5-10 parts of liquorice extract and 5-10 parts of ginkgo extract. The wet wound dressing only needs to be sprayed or coated on the surface of a wound, after ethanol in the dressing is volatilized, a layer of breathable film can be formed on the surface of the wound, the breathability is good, the active ingredients in the dressing all adopt pure plant extract, chemical reagents are not contained, the plant ingredients interact, the wound healing can be promoted while sterilization and inflammation diminishing are achieved, and scars are prevented.
Description
Technical Field
The invention relates to the technical field of clinical medical supplies, in particular to a wet wound dressing and a preparation method thereof.
Background
Skin is the first barrier of human body to resist external bacteria invasion, and is the tissue with the largest body area, and the damage of skin tissue not only can cause the damage of subcutaneous tissue, but also can influence the internal balance of the body. At present, a common wound treatment mode is to adhere a wound patch to the outside of a wound to isolate the wound from the outside. The adhesive tape on the outer layer of the adhesive tape is airtight, so that the skin around the wound and the wound is softened, the wound is further deteriorated, and the wound is not favorable for healing of the wound.
Disclosure of Invention
The invention aims to provide a wet wound dressing which can solve the problem of poor wound healing capability of a wound plaster in the prior art. In addition, the invention also provides a preparation method of the moist wound dressing.
In order to solve the problems, the invention adopts the following technical scheme:
in a first aspect of the invention, there is provided a moist wound dressing comprising the following components in parts by weight: 120-160 parts of polyvinyl alcohol, 5-30 parts of chitosan, 10-20 parts of polyethylene glycol, 600-800 parts of ethanol, 10-20 parts of onion extract, 10-20 parts of asiatic pennywort herb extract, 5-15 parts of aloe extract, 5-10 parts of liquorice extract and 5-10 parts of ginkgo extract.
Further, the composition comprises the following components in parts by weight: 130-150 parts of polyvinyl alcohol, 10-20 parts of chitosan, 5-15 parts of polyethylene glycol, 650-750 parts of ethanol, 5-15 parts of onion extract, 5-15 parts of asiatic centella extract, 8-12 parts of aloe extract, 6-8 parts of liquorice extract and 6-8 parts of ginkgo extract.
Further, the composition comprises the following components in parts by weight: 140 parts of polyvinyl alcohol, 15 parts of chitosan, 15 parts of polyethylene glycol, 700 parts of ethanol, 15 parts of onion extract, 15 parts of asiatic centella extract, 10 parts of aloe extract, 7 parts of liquorice extract and 7 parts of ginkgo extract.
In a second aspect of the invention, there is provided a method of preparing a moist wound dressing, for preparing a wound dressing as described above, comprising the steps of: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
Furthermore, the preparation method of the onion extract comprises the following steps: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
Furthermore, the preparation method of the centella asiatica extract comprises the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
Further, the preparation method of the aloe extract comprises the following steps: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
Further, the preparation method of the liquorice extract comprises the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
Further, the preparation method of the ginkgo biloba extract comprises the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
The Bulbus Allii Cepae is a herb plant composed of fleshy scales and scaly teeth in Allium of Liliaceae, and allicin active compounds in Bulbus Allii Cepae extract have bactericidal effect, and can react with compounds having sulfhydryl group to prevent combination with protein, and the reaction can inhibit bacteria growth.
The asiaticoside is a regulator for promoting wound healing, has effects of activating epithelial cells, promoting normal granulation tissue formation, inhibiting fibroblast proliferation, inhibiting and delaying unordered scar tissue proliferation, preventing adhesion, and relieving adhesion formation. Can be used for treating dermatoses such as skin ulcer, burn, wound, and tendon adhesion.
The aloe-emodin, aloe tincture and aloe extract A in the aloe extract have antibacterial effect, and bacteria do not produce drug resistance, and can simultaneously remove harmful metabolites produced during infection and endotoxin produced by dead bacteria, and has hemostatic, antiinflammatory and healing effects on skin wound.
The Glycyrrhrizae radix extractive solution can inhibit the activity of tyrosinase and dopachrome tautomerase (TRP-2), and inhibit the polymerization of 5, 6-dihydroxyindole (DHl), so as to prevent melanin formation and scar formation during wound healing.
The extractive solution contains bilobalide, bilobalide A, bilobalide B and bilobalide C, and has effects of promoting blood circulation, inhibiting platelet adhesion, promoting blood circulation, and removing blood stasis.
The wet wound dressing only needs to be sprayed or coated on the surface of a wound, after ethanol in the dressing is volatilized, a layer of breathable film can be formed on the surface of the wound, the breathability is good, the active ingredients in the dressing all adopt pure plant extract, chemical reagents are not contained, the plant ingredients interact, the wound healing can be promoted while sterilization and inflammation diminishing are achieved, and scars are prevented.
Detailed Description
Example 1
A moist wound dressing is composed of the following components: 140g of polyvinyl alcohol, 15g of chitosan, 15g of polyethylene glycol, 700g of ethanol, 15g of onion extract, 15g of asiatic centella extract, 10g of aloe extract, 7g of liquorice extract and 7g of ginkgo extract.
The preparation method comprises the following steps: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
The preparation method of onion extract comprises: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
The preparation method of the centella extract comprises the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the aloe extract comprises the following steps: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
The preparation method of the licorice extract comprises the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the ginkgo extract comprises the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
Example 2
A moist wound dressing is composed of the following components: 120g of polyvinyl alcohol, 30g of chitosan, 10g of polyethylene glycol, 800g of ethanol, 10g of onion extract, 20g of asiatic centella extract, 5g of aloe extract, 10g of liquorice extract and 5g of ginkgo extract.
The preparation method comprises the following steps: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
The preparation method of onion extract comprises: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
The preparation method of the centella extract comprises the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the aloe extract comprises the following steps: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
The preparation method of the licorice extract comprises the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the ginkgo extract comprises the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
Example 3
A moist wound dressing is composed of the following components: 160g of polyvinyl alcohol, 5g of chitosan, 20g of polyethylene glycol, 600g of ethanol, 20g of onion extract, 10g of asiatic centella extract, 15g of aloe extract, 5g of liquorice extract and 10g of ginkgo extract.
The preparation method comprises the following steps: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
The preparation method of onion extract comprises: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
The preparation method of the centella extract comprises the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the aloe extract comprises the following steps: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
The preparation method of the licorice extract comprises the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the ginkgo extract comprises the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
Example 4
A moist wound dressing is composed of the following components: 130g of polyvinyl alcohol, 20g of chitosan, 5g of polyethylene glycol, 750g of ethanol, 5g of onion extract, 15g of asiatic centella extract, 8g of aloe extract, 8g of liquorice extract and 6g of ginkgo extract.
The preparation method comprises the following steps: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
The preparation method of onion extract comprises: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
The preparation method of the centella extract comprises the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the aloe extract comprises the following steps: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
The preparation method of the licorice extract comprises the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the ginkgo extract comprises the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
Example 5
A moist wound dressing is composed of the following components: 150g of polyvinyl alcohol, 10g of chitosan, 15g of polyethylene glycol, 650 parts of ethanol, 15g of onion extract, 5g of asiatic centella extract, 12g of aloe extract, 6g of liquorice extract and 8g of ginkgo extract.
The preparation method comprises the following steps: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
The preparation method of onion extract comprises: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
The preparation method of the centella extract comprises the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the aloe extract comprises the following steps: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
The preparation method of the licorice extract comprises the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
The preparation method of the ginkgo extract comprises the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
Clinical trial
Experimental groups: example 1
Control group: commercially available adhesive bandage
The test population: mouse (5)
The test method comprises the following steps: two wounds were scratched on the back of each mouse, each wound being 4mm long, 4mm wide and 2mm deep.
The wound distribution pattern is shown in Table 1
TABLE 1
| Wound 1 | Wound 2 | |
| Mouse 1 | Example 1 | Commercially available adhesive bandage |
| Mouse 2 | Example 2 | Commercially available adhesive bandage |
| Mouse 3 | Example 3 | Commercially available adhesive bandage |
| Mouse 4 | Example 4 | Commercially available adhesive bandage |
| Mouse 5 | Example 5 | Commercially available adhesive bandage |
The healing of the wounds of the test mice is shown in Table 2
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.
Claims (9)
1. A moist wound dressing is characterized by comprising the following components in parts by weight: 120-160 parts of polyvinyl alcohol, 5-30 parts of chitosan, 10-20 parts of polyethylene glycol, 600-800 parts of ethanol, 10-20 parts of onion extract, 10-20 parts of asiatic pennywort herb extract, 5-15 parts of aloe extract, 5-10 parts of liquorice extract and 5-10 parts of ginkgo extract.
2. The moist wound dressing according to claim 1, comprising the following components in parts by weight: 130-150 parts of polyvinyl alcohol, 10-20 parts of chitosan, 5-15 parts of polyethylene glycol, 650-750 parts of ethanol, 5-15 parts of onion extract, 5-15 parts of asiatic centella extract, 8-12 parts of aloe extract, 6-8 parts of liquorice extract and 6-8 parts of ginkgo extract.
3. The moist wound dressing according to claim 1, comprising the following components in parts by weight: 140 parts of polyvinyl alcohol, 15 parts of chitosan, 15 parts of polyethylene glycol, 700 parts of ethanol, 15 parts of onion extract, 15 parts of asiatic centella extract, 10 parts of aloe extract, 7 parts of liquorice extract and 7 parts of ginkgo extract.
4. A method of preparing an moist wound dressing according to any one of claims 1 to 3, including the steps of: adding polyvinyl alcohol, chitosan, polyethylene glycol and ethanol into a stirring kettle, and fully and uniformly stirring to obtain a film forming solution; adding onion extract, centella extract, aloe extract, liquorice extract and ginkgo extract into the film forming solution in sequence, and fully and uniformly stirring to obtain the wet wound dressing.
5. The method of preparing a moist wound dressing according to claim 4, wherein the onion extract is prepared by the following method: removing onion skin, pulverizing onion into paste, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
6. The method of preparing a moist wound dressing according to claim 4, wherein the extract of centella asiatica is prepared by the following steps: reflux-extracting dried herba Centellae with ethanol solution, adding distilled water, and filtering to obtain filtrate.
7. A method of preparing a moist wound dressing according to claim 4, in which the aloe extract is prepared by: removing aloe leaves, cleaning, air drying, crushing, collecting homogenate, centrifuging by a centrifuge, and collecting supernatant.
8. The method of preparing a moist wound dressing according to claim 4, wherein the licorice extract is prepared by the following steps: reflux-extracting dried Glycyrrhrizae radix with ethanol solution, adding distilled water, and filtering to obtain filtrate.
9. The method of preparing a moist wound dressing according to claim 4, wherein the ginkgo biloba extract is prepared by the following steps: cleaning semen Ginkgo, air drying, adding ethanol solution, leaching at pH of 5-6 for 24 hr, and filtering to obtain filtrate.
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| CN201811335546.7A CN111166929A (en) | 2018-11-09 | 2018-11-09 | Wet wound dressing and preparation method thereof |
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| CN201811335546.7A CN111166929A (en) | 2018-11-09 | 2018-11-09 | Wet wound dressing and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112294910A (en) * | 2020-12-24 | 2021-02-02 | 中国人民解放军北部战区总医院 | Medicine for treating strontium 90 scars and preparation method thereof |
| CN112316196A (en) * | 2020-11-03 | 2021-02-05 | 辽宁燕阳医疗设备有限公司 | Wound dressing containing plant extract and application thereof |
| CN112494603A (en) * | 2020-12-25 | 2021-03-16 | 杭州甜蜜按钮科技有限公司 | Preparation method of hand mask ointment for promoting wound healing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112316196A (en) * | 2020-11-03 | 2021-02-05 | 辽宁燕阳医疗设备有限公司 | Wound dressing containing plant extract and application thereof |
| CN112294910A (en) * | 2020-12-24 | 2021-02-02 | 中国人民解放军北部战区总医院 | Medicine for treating strontium 90 scars and preparation method thereof |
| CN112494603A (en) * | 2020-12-25 | 2021-03-16 | 杭州甜蜜按钮科技有限公司 | Preparation method of hand mask ointment for promoting wound healing |
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Application publication date: 20200519 |
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