WO2017030388A1 - Composition for treating skin wounds - Google Patents

Abstract

The present invention relates to a composition for treating skin wounds. In the present invention, a herb extract-containing glycerin is mixed with a collagen and applied to a skin wound. The glycerin applied to the skin wound kills the infecting bacteria and other contaminants by using high osmotic pressure to discharge an exudate from inside the skin to the skin wound. The herb extract stimulates wound treatment by neutralizing intercellular matrix-destroying proteolytic enzymes to regenerate the matrix and thereby stimulate cell growth. The added collagen not only neutralizes collagenases more quickly, but by combining with the glycerin to suppress the evaporation of moisture and thereby maintain the moisturized state, exhibits a pain-relieving effect, covers the wound, and stimulates the wound treatment effect.

Description

Skin Wound Healing Composition

The present invention relates to a composition for treating skin wounds, and more particularly, to a composition for treating skin wounds, which can alleviate and heal pain in skin wounds such as burns, traumas, wounds and pressure sores.

Skin is an important organ with the largest surface area in the body, and if the skin is extensively damaged, it may lose its life due to dehydration. The skin must be resistant to physical irritation and elasticity because it serves to protect against and to prevent dehydration and to regulate body temperature by inhibiting evaporation of the human body.

However, if the skin is resistant to elasticity and elasticity is caused by various causes such as burns, trauma, wounds, bedsores and skin diseases, the wound is inevitable skin transplantation in the case of wounds that are not primary suture Since the scars are left behind, it is necessary to promptly treat the wound in order to repair the damaged skin tissue, and it is essential to dress and treat the secondary to minimize various side effects.

In addition, when the wound of the skin is damaged to the internal tissues along with damage to the skin or mucous membrane covering the main part of the body, the damaged skin or mucous membrane contains dying cells, microorganisms, contaminants, Cells, microorganisms and contaminants contained must be removed or degraded, whereby protease is secreted to degrade the cells, microorganisms and contaminants.

However, when the secreted protease is excessively secreted, the excess protease decomposes and destroys the intercellular collagen matrix and elastin matrix, which are essential for cell growth and cell adhesion, thereby inhibiting cell growth. This will delay wound healing.

Therefore, inhibition of the protease promotes cell growth by attaching to the intercellular matrix (MMPs: matrix metalloproteins).

Herein, the intercellular matrix (MMPs: matrix metalloproteins) include proteins, collagen, elastin hyaluronic acid, and the like, which fill a space between cells.

Since the intercellular matrices (MMPs) are of different types, they require different types of neutralizing specific polyphenols. These are two specific plant extracts that are not related to each other, thereby stopping the breakdown of the intercellular matrix and having a synergistic effect on cell growth. Thus, different types of intercellular matrix (MMPs) can be converted into two neutralizing polyphenols or polysaccharides. Alternatively, it is possible to have three types.

The vegetable extract (herb extract) uses tannic acid, which has been used for all leather since Egyptian times, because tannic acid has the ability to bind proteins.

The tannic acid is a component in the persimmon persimmon, and in terms of molecular structure, polyphenols and polysaccharides are attached, and procyanidine or ansocyanidin in a dark-colored fruit with antioxidant activity. Also called (anthocyanidine).

Herbal extracts that have the ability to bind to proteolytic enzymes are a type of Alchemilla vulgaris, and other extracts bind to viruses or other proteins. Therefore, if glycerin contains other herbal extracts, it is effective for other types of wounds.

Here, the plant extract may neutralize proteolytic enzymes by combining polyphenols and polysaccharides known to precipitate large molecules with proteolytic enzymes.

The polyphenols and polysaccharides have a strong affinity for proteins, and some polyphenols or polysaccharides bind to bacteria or viral proteins to reduce the release of toxic substances of infection, microbial origin, and cell growth. It helps to promote.

In the last decades, many products have been developed for the treatment of various wounds, including skin wounds. As a result, there have been many changes in the paradigm of wound healing, and at the heart of the concept are hydrophilic colloids, hydro-foams, hydro-gels and hydro-fibers. Wet dressing is represented by.

In addition, we recently developed various biological dressing products such as epidermal growth factor and fibroblast growth factor, hyaluronic acid dressing, collagen dressing and cultured epithelial allograft as additional therapeutic materials to shorten the wound healing period. It is being used with the products.

In addition to such synthetic and biological products, the development of products utilizing various materials derived from nature as a dressing material for wound healing is being made.

As part of this, Alchemilla Vulgaris is a herb that has been used for the treatment of gastrointestinal disorders and wounds since the Middle Ages, and Mimosa (Timosa Tenuiflora) has traditionally been used to treat skin wounds, burns, and oral wounds. Both herbal extracts are rich in Procyanidins.

The mechanism by which procyanidins promote wound healing is not yet clear, but it helps to heal wounds by inhibiting the activity of protease and other cellular degrading enzymes (MMPs) in the wound. It is estimated to promote the healing by forming an environment conducive to cell adhesion and growth.

Collagen is also used for wound healing, which is a fibrous protein found in most connective tissues such as skin, muscles and tendons, especially in animals and humans. When collagen comes into contact with blood, platelets aggregate to collagen and maintain coagulation factors that are released together with plasma to finally form fibrin and thrombus to act as a hemostatic action.

When collagen is used for wound healing purposes, the first formulation is a powder. Collagen is the first protein to be temporarily formed in the empty space during the wound treatment process, and despite the expectation that it will promote wound healing, the powder formulation has been limited in use due to some disadvantages.

When collagen powder is sprayed on the wound site, the exudates from the wound area are absorbed and dried, causing pain and lack of moisture, leaving the wound unscathed and leaving a significant scar.

Sponge-type collagen products have been developed to compensate for these drawbacks, but this formulation also caused other drawbacks. When the sponge-like product was covered on the wound area, the wound treatment did not have much effect to promote the wound treatment because it could not be in close contact with the wound and an empty space was created.

In order to make up for this drawback, a new formulation was developed by crushing a sponge of a new formulation to make road collagen powder, mixed with saline solution, and then making it into a paste or dough to apply to a wound site. US Patent No. 4,891,359 (Hemostatic Collagen Paste Composition) was developed.

This product was prepared by mixing saline with collagen powder, paste or paste, and applying it closely to the wound surface to easily remove it from the wound after hemostasis and hemostasis.

However, the prior art is not only used as a hemostatic agent by mixing saline with collagen to be in close contact with the wound surface, but there is an insufficient problem of promoting wound healing, and moisture is easily evaporated. There is a problem that the pain relief effect is low and dries easily.

An object of the present invention to solve the above problems is to discharge the exudate from the inside of the wound, to remove microorganisms and other contaminants, to inhibit proteolytic enzymes to neutralize their activity by inhibiting the decomposition of the matrix cell growth of the wound site And not only to promote treatment, but also to increase the density by adding collagen to increase the blocking effect with the air to increase the pain relief effect.

Means of the present invention according to the solution of the above problem is characterized by mixing 5wt% to 50wt% of powdered collagen in a liquid glycerin containing 2wt% to 5wt% of the vegetable extract to 50wt% to 95wt%.

In the means of the present invention, the vegetable extract is Vitis vinifera, Camellia sinensis, Basinium sp., Vaccinium sp., Vaccinoum myrtillus, Alchemilla vulgaris (Alchemilla vulgaris), Mimosa tenuiflora (Mimosa tenuiflora), Echinacea purpura (Echinacea purpura) is characterized in that the extract.

The effect of the present invention according to the problem solution means by applying collagen to the skin wound by mixing the glycerin containing the herbal extract, the glycerin applied to the skin wound is discharged exudates from the inside of the skin wound by the high osmotic pressure to the skin wound Sterilizes infected bacteria and other contaminants, herbal extracts promote wound healing by neutralizing proteolytic enzymes that break down the intercellular matrix, repairing the matrix and promoting cell growth, and the collagen accelerates protease faster It not only neutralizes, but also maintains a moisturizing condition by inhibiting water evaporation along with glycerin, which acts as a pain relief and wound cover and promotes wound healing.

1 is a photograph of the result of the treatment before and after applying the present invention skin wound treatment to bedsores

Figure 2 before and after the application of the present invention skin wound treatment to the bedsores photograph

Figure 3 before and after applying the present invention skin wound treatment to the bedsores treatment result photograph

Figure 4 before and after the application of the present invention skin wound treatment on the burn photo

The present invention is prepared by mixing powdered collagen (collagen) to a liquid glycerin (Glycerol). The glycerin (Glycerol) will contain any one of vegetable extracts or herbal extracts. Preferably it contains a herb extract.

Hereinafter, embodiments will be described based on the accompanying drawings.

The glycerin (Glycerol) can heal the wound with a high moisturizing effect, but only a very small effect of relieving pain by the moisturizing effect. The high concentration of glycerin constricts the cells in the sieve and draws out exudate that moves out of the tissue, and the exudate exudes in combination with the herb extract, which will be described later, to prevent it from entering the sieve.

That is, in the case of hypertonic solution, the osmotic pressure is high so that the exudate in the skin moves toward the glycerin, and the herbal extracts in the hypertonic solution do not re-enter the tissue by catching different substances. Therefore, the glycerin is combined with the herbal extract to apply a film on the wound in a state where the viscosity is higher.

The glycerin has a high osmotic pressure and a binding force in the form of a polymer, so it exists outside the wound without penetrating into the tissue. Therefore, exudates come out of the tissues along with viruses and contaminants in the wound to clean the wound and facilitate the healing of the wound.

The herbal extract is a tannin component present in the plant, and the hydroxyl group and the carbonic acid group of the glycerin are combined to form a precipitate, and each tannin has a different kind of action. Therefore, different types of herbal extracts have different effects, and there are various types of diseases that can be treated.

The collagen is a triple helical structure, especially a protein substance with a high hydroproline content, and is insoluble in water, dilute acid and dilute alkali, but dissolves and becomes gelatin. When applied to the wound, it acts as a temporary skin to promote wound healing.

Example

50wt% to 95wt% of liquid glycerin is mixed with 5wt% to 50wt% of collagen in powder form of 40 to 60 mesh particles, and then prepared by lowering the internal air pressure.

The liquid glycerin will contain a vegetable extract.

The vegetable extract will contain 2wt% ~ 5wt%.

The plant extracts are Vitis vinifera, Camellia sinensis, Vaccinium sp., Vaccinoum myrtillus, Alchemilla vulgaris ), Extracts of any one of Mimosa tenuiflora and Echinacea purpura will be used.

Herein, the present invention preferably contains 90 wt% of the liquid glycerin and 10 wt% of the collagen.

Therefore, the active hypertonic component releases the exudates from the inside of the wound to the outside by glycerin, thereby separating and discharging the microorganisms and other contaminants of the wound outwards, thereby facilitating the healing of the wound.

The exudates of microorganisms and contaminants that are separated and discharged to the outside are adsorbed with procyanidin-rich herbal extracts to prevent the exudates from entering the inside again and neutralize their activities by inhibiting proteolytic enzymes that destroy the matrix between cells. Proliferation of the matrix between cells promotes treatment.

The collagen is a structural protein constituting the extracellular matrix, a white transparent unbranched fibrils composed of a plurality of sugar protein molecules. The monomer of collagen protein is procollagen, and the procollagen molecule is composed of three long and thin spiral chains.The electron microscope has a stable triple helix space structure of 1.5nm in diameter, 300nm in length and 2.85 × 105 in relative molecular mass. It is composed of special amino acids.

The collagen is a protein that connects cells to cells to form flesh and connective tissue, and exists as an intercellular matrix, and accounts for 25% to 35% of the proteins constituting the body and is a fibrous form of tendons, ligaments, It is present in fibrous tissues such as skin.

The collagen is a special protein contained in animal skin or cartilage. It is insoluble in water, extracted by heating in water, and extracted by heating. The steric structure is collapsed to have a denatured protein called gelatin, that is, a liquid upon heating and a solid upon cooling.

Therefore, when the collagen is applied to the wound of the skin, it combines the cells of the skin and the cells to promote the thickness of the skin, and also inhibits the evaporation of the moisture of the skin to have a hemostatic action, resistance, disintegration and biocompatibility, clinical hemostasis And promote cell growth to promote wound healing.

	Example 1	Example 2	Example 3
Glycerin (wt%) + Herb Extract (wt%)	50	90	95
Collagen (wt%)	50	10	5

As shown in the photograph of FIG. 1, the present invention in the form of a gel prepared in Examples 1 to 3 was treated by applying a thickness of 1 g to the wound of a bed sore patient.

As a result, the wound area that started treatment with the general treatment showed a deteriorated state even after 10 days once a day, but after 7 weeks of treatment three times a week with the present invention, the wound remains. Neatly healed.

In addition, the present invention was treated by applying a 1g thickness to the wound of the bed sore patient, as shown in the photo of FIG.

As a result, the wound site that started treatment with the general treatment showed a worse condition after 11 weeks once a day, but after 4 treatments with the present invention 4 times a week, scars remained relatively little at the wound site. Neatly healed.

In addition, the present invention was treated by applying a thickness of 1g to the wound of the bed sore patient, as shown in the photo of FIG.

As a result, the decubitus area that started treatment with a general treatment showed a lot of wounds after 1 week once a week, but as a result of treatment twice a week and 10 times every 5 weeks with the present invention, the wound site was neat. It did not heal, but it was almost healing.

Next, the present invention was also treated by applying a thickness of 1 g to the wound of the burn patient, as shown in the photograph of FIG. 4.

As a result, the burned area that started treatment with the general treatment showed a lot of wounds after 12 weeks once a day, but the treatment with the general treatment was performed twice a week and 10 times in 5 weeks with the present invention. Although the burn wound was almost neatly healed, it was found that in the case of the burn wound that started treatment with the present invention, the wound wound was healed in a relatively fast time compared to the number of times of the start of treatment with the general treatment.

Therefore, as shown in Figs. 1 to 4, the wounds of the bedsores and burns with the present invention are cured in a considerably faster time than the general treatment, and the wounds are cleanly cleared with almost no scars on the wounds. I could see that.

The prior art is not only used as a hemostatic agent by adhering saline to collagen but in close contact with the wound surface, and there is an insufficient problem of promoting wound healing. In the present invention, there was a problem that the relaxation effect was low and easily dried, so that the conventional problem could be solved.

Claims (2)

1. A composition for treating skin wounds comprising mixing 2wt% to 5wt% of vegetable extracts and mixing 5wt% to 50wt% of powdered collagen at room temperature in a liquid glycerin which is 50wt% to 95wt%.
2. The method of claim 1,

   The vegetable extract is Vitis vinifera, Camellia sinensis, Basinium sp., Vaccinium myrtillus, Alchemyra vulgaris ), Mimosa tenuiflora, Echinacea purpura extract of any one of the skin wound composition.

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