CN107427561A - Skin wound therapeutic combination - Google Patents
Skin wound therapeutic combination Download PDFInfo
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- CN107427561A CN107427561A CN201680019591.4A CN201680019591A CN107427561A CN 107427561 A CN107427561 A CN 107427561A CN 201680019591 A CN201680019591 A CN 201680019591A CN 107427561 A CN107427561 A CN 107427561A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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Abstract
The present invention relates to skin wound therapeutic combination.In the present invention, collagen is mixed in the glycerine containing vanilla extract solution, to be coated on skin wound, so as to which the glycerine coated on skin wound discharges exudate inside skin by hyperosmosis to skin wound, to be sterilized to the bacterium infected and other polluters, and vanilla extract solution is neutralized to repair matrix to the proteolytic enzyme for destroying intercellular matrix, so as to promote the growth of cell, thus Wound healing and bone regeneration is promoted, and the collagen added not only quickly neutralizes clostridiopetidase A, and together suppress moisture evaporation with glycerine to keep moisturizing state, so as to play a part of pain remission effect and covering wound, and promote Wound healing and bone regeneration effect.
Description
Technical field
The present invention relates to skin wound therapeutic combination, relates to make such as burn, wound, wound, bedsore in more detail
Deng skin wound position the pain skin wound therapeutic combination alleviating and cure.
Background technology
Important organ of the skin as the surface area for occupying maximum in the body, widely sustains damage in above-mentioned skin
In the case of, because of dehydration it is also possible to losing life, and above-mentioned skin plays microorganism or the various hostile environments from outside,
Such as moisture evaporation of ultraviolet, bacterium, the effect of chemical substance protection and suppression human body, prevents from being dehydrated and adjusts so as to play
The effect of body temperature, therefore skin needs to be better than physical stimulation and flexible.
But it is being better than above-mentioned stimulation and the springy skin of tool because of such as burn, wound, wound, bedsore and disease of skin
In the case of being damaged Deng many reasons, now, the feelings of the wound of first time suture can not be carried out in impaired above-mentioned skin presence
Under condition, dermatoplastic serious scar must be carried out by leaving, therefore in order to repair impaired skin histology, it is necessary to carry out rapidly
Wound healing and bone regeneration, and secondary strategic point must be treated in order to which various side effects are minimized in a manner of dressing.
Also, in the wound of above-mentioned skin, the damage of the skin or mucous membrane of the major part with covering body is together damaged
In the case of hurting interior tissue, cell, microorganism and the polluter die are included in the skin or mucous membrane of above-mentioned damage,
So as to need to remove or decompose the cell for being contained in above-mentioned skin or mucous membrane, microorganism and polluter, wherein, on decomposing
State cell, microorganism, polluter and secretory protein hydrolase (protease).
But in the case of secreted above-mentioned proteolytic enzyme surplus, growth of the superfluous proteolytic enzyme to cell
And necessary iuntercellular collagen (Collagen) matrix and elastin laminin (Elastin) matrix are decomposed and broken in cell attachment
It is bad, to suppress the growth of cell, so as to postpone Wound healing.
Therefore, if suppressing above-mentioned proteolytic enzyme (protease), it is attached to above-mentioned intercellular matrix (matrix metal egg
White enzyme (MMPs)：Matrix metalloproteins) promote the growth of cell.
Wherein, the space between tytosis and cell is included as above-mentioned intercellular matrix (matrix metalloproteinase)
Protein, collagen, elastin laminin hyaluronic acid etc..
Because above-mentioned intercellular matrix (matrix metalloproteinase) is mutually different type, it is therefore desirable to neutralize specific more
The other types of phenol.Even if this is onrelevant, two specified plant extracts are also served as, so as to stop the decomposition of intercellular matrix
To have the upper ascending effect related to cell growth, therefore it is directed to the difference of above-mentioned intercellular matrix (matrix metalloproteinase)
Type can realize with two or three types for neutralizing polyphenol or polysaccharide.
Used when using as above-mentioned plant extracts (vanilla extract solution) and carry out tanning to leather from the Egyptian epoch
Tannic acid, because tannic acid has the ability being combined with protein.
Above-mentioned tannic acid is the composition that has in puckery persimmon, be from molecular structure with polyphenol (Polyphenol) and
The form of polysaccharide (Polysaccharide), the former cyanine also known as having in the dark colour fruit with antioxidation
Plain (procyanidine) or anthocyanidin (anthocyanidine).
Vanilla extract solution with the ability being combined with above-mentioned proteolytic enzyme is garment or robe made of feathers grass (Alchemilla
Vulgaris one kind), other extract solutions are combined with virus or other protein.If therefore contain other vanillas in glycerine
Extract solution, then it is effective to other kinds of wound.
Wherein, in above-mentioned plant extracts, it is known that to make the polyphenol (Polyphenol) and more that macromolecular precipitates
Carbohydrate (Polysaccharide) is combined that proteolytic enzyme can be neutralized with proteolytic enzyme.
Above-mentioned polyphenol (Polyphenol) and polysaccharide (Polysaccharide) have strong affine with albumen qualitative correlation
Property, one part polyphenol or polysaccharide are combined with bacterium or viral proteins to reduce infection, the poison originating from microorganism
The liberation of property material, so as to help lend some impetus to cell growth.
Over the past several decades, multiple product is developed in order to treat the various wounds including skin wound.Thus, controlled in wound
For the pattern for the treatment of also there occurs many changes, can be described as the center of its concept is moistening dressing, is had as typical moistening dressing
Hydrophily colloid (hydro-colloid), hydrophilic foam (hydro-foam), hydrophilic gel (hydro-gel) and hydrophilic
Property fiber (hydro-fiber).
Also, recently as the additional treatment material during the healing for shortening wound, Persisting exploitation various biological
Casting product such as growth factor (EGF and fibroblast growth factor (Epidermal growth factor
And Fibroblast growth factor)), hyaluronic acid dressing (hyaluronic acid dressing), collagen applies
Expect (Collagen dressing) and epithelial cell allograft (the Cultured epithelial of culture
) etc. allograft various biological casting product is used together with moistening casting product.
In addition to this sintetics and biological products, the dressing saw lumber for healing a wound also carries out utilizing source
In the exploitation of the product of natural many kinds of substance.
As one ring, the one kind of garment or robe made of feathers grass (Alchemilla Vulgaris) as vanilla, started with from Middle Ages
In the treatment of gastric tube obstacle and the treatment of wound, sensitive plant (sensitive plant (Mimosa Tenuiflora)) is conveniently employed in and controlled
The wound of skin or the wound in the treatment of burn and oral cavity etc. are treated, in two above-mentioned vanilla extract procyanidins
(Procyanidins) enrich.
The mechanism that above-mentioned OPC promotes the healing of wound is not yet clear and definite, but according to presumption, suppresses to divide in wound
Other enzyme (intercellular matrix digestive enzymes of proteolytic enzyme (protease) and intercellular matrix (matrix metalloproteinase)
(intercellular matrix degrading enzymes)) activity, come the cell that helps to heal a wound
The environment of attachment and growth promotes to cure.
Also, collagen is utilized for the healing of wound, most of above-mentioned collagen is to be present in the albumen of animal or people
Matter, especially, the fibroid protein found in tissue is connected in such as skin, muscle, tendon etc., when above-mentioned collagen connects with blood
When touching, platelet aggregation is kept in collagen, and the coagulation factors peeled off together with blood plasma, finally to form blood with fibrin
Bolt plays anastalsis.
When collagen as the purpose of Wound healing and bone regeneration in use, initial formulation is powder.The collagen in wound treatment protocol
For be temporarily formed at first in sky space in protein, it is therefore contemplated that promote Wound healing and bone regeneration, but due to powder form exist
Several shortcomings, thus use is restricted.
If collagen powder is spread on into wound location, the exudate of wound location is absorbed to become drying, therefore induce pain
Disease and without moisture, therefore wound without normal therapeutic process and leaves larger scar.
In order to make up this shortcoming, the collagen of sponge form is developed, but above-mentioned formulation, which also induces other, to be lacked
Point.If the product of sponge form is covered in into wound location, it is not close to wound, produces gap, therefore promote Wound healing and bone regeneration
Effect it is little.
Opened to make up this shortcoming in US granted patent No. 4,891,359 (styptic collagen paste composition)
Hair is re-prepared as collagen powder by crushing the sponge of novel form, to be prepared by mixing into paste or batter with saline solution.
The said goods are formed in a manner of in collagen powder mixing saline solution, and it is paste (paste) or batter to form, and is come
Nearly it is applied to wound surface, so as to be easily removed from wound location after simply stopping blooding and stopping blooding.
But in the above prior art, saline solution is only mixed in collagen to be nearly in contact with wound surface, so as to
Only it is used as styptic, the Shortcomings point in the effect for promoting Wound healing, also, moisture easily evaporates, thus it is empty
Gas barriering effect is low, and it is low pain remission effect to be present, and the problem of easily dry.
The content of the invention
Technical problem
Technical problem of the invention for solving the above problems is, micro- to remove from wound inside discharge exudate
Biology and other polluters, and suppress proteolytic enzyme to neutralize their activity, so as to suppress the decomposition of matrix, not only
Promote cell growth and the treatment of wound location, and density, increase and the barriering effect of air improved by adding collagen,
So as to increase pain remission effect.
Solution to problem
It is characterised by based on the solution of the present invention for solving above-mentioned technical problem, under normal temperature condition, is containing 2~5
The powder of 5~50 percentage by weights is mixed in the liquid glycerine of 50~95 percentage by weights of the plant extracts of percentage by weight
The collagen of shape.
In the scheme of the invention described above, it is characterised in that above-mentioned plant extracts be grape (Vitis vinifera),
Tea tree (Camellia sinensis), blueberry (Vaccinium sp.), black fruit blueberry (Vaccinoum myrtillus), plumage
Clothing grass (Alchemilla vulgaris), sensitive plant (Mimosa tenuiflora), Echinacea (Echinacea purpura)
In a kind of extract solution.
The effect of invention
Effect of the invention based on above-mentioned solution to problem is as follows：Mixed in the glycerine containing vanilla extract solution
Collagen, to be coated on skin wound, so as to which the glycerine coated on skin wound is hindered by hyperosmosis inside skin to skin
Mouth discharge exudate, to be sterilized to the bacterium infected and other polluters, and vanilla extract solution is to destroying cell
Between the proteolytic enzyme of matrix neutralized to repair matrix, so as to promote the growth of cell, thus promote Wound healing and bone regeneration, and
And the collagen added not only quickly neutralizes clostridiopetidase A, and together suppress moisture evaporation with glycerine to keep moisturizing state,
So as to play a part of pain remission effect and covering wound, and promote Wound healing and bone regeneration effect.
Brief description of the drawings
Fig. 1 is coated on the forward and backward treatment results photo of bedsore by the skin wound therapeutic agent of the present invention.
Fig. 2 is coated on the forward and backward treatment results photo of bedsore by the skin wound therapeutic agent of the present invention.
Fig. 3 is coated on the forward and backward treatment results photo of bedsore by the skin wound therapeutic agent of the present invention.
Fig. 4 is coated on forward and backward treatment results photo of burning by the skin wound therapeutic agent of the present invention.
Embodiment
In the present invention, in liquid glycerine (Glycerol) collagen (collagen) of mixing powdery and prepare.On
Glycerine (Glycerol) is stated containing one kind in plant extracts or vanilla extract solution.Preferably, containing vanilla extract solution.
Embodiment is illustrated referring to the drawings.
Above-mentioned glycerine (Glycerol) alleviates pain because high moistening effect can heal a wound by above-mentioned moistening effect
Effect only and one part.The glycerine of high concentration makes internal cellular contraction, is moved to be drawn to outside tissue to outside
Dynamic exudate, the above-mentioned exudate drawn are combined with vanilla extract solution described later to prevent from being again introduced into internal.
That is, in the case of hypertonic solution (hypertonic solution), the exudate in skin because of osmotic pressure height
Go out to the movement of glycerine side, and the species of the vanilla extract solution in hypertonic solution catches other materials to prevent from entering again
Enter in tissue.Therefore, above-mentioned glycerine is combined thin to be applied in wound location in the state of being uprised in viscosity with vanilla extract solution
Film.
Above-mentioned glycerine has hyperosmosis, and has adhesion in the form of polymer, therefore is not permeated into tissue,
It is present in outside wound.Therefore, if exudate flows out to outside tissue, the virus and a polluter also cocurrent flow that are present in wound
Go out, therefore wound is become clean, and promote the treatment of wound.
Above-mentioned vanilla extract solution is as tannic acid (tannin) composition for being present in plant, the hydroxyl and carbonate of above-mentioned glycerine
It is combined with protein and forms precipitation, each tannic acid each serves as different types of effect.Therefore according to vanilla extract solution
Different-effect is presented in species, and the species of medicable disease is also various.
Above-mentioned collagen has the protein material more than triple helices shape structure, the especially content of hydroxy-proline, insoluble
Xie Yushui, diluted acid and diluted alkaline, but boil just dissolving and turn into gelatin.When coated on wound, play a part of temporary skin
Promote Wound healing and bone regeneration.
Embodiment
The particle size that 5~50 percentage by weights are mixed in the liquid glycerine of 50~95 percentage by weights is 40 mesh to 60
After the collagen of mesh powder shape, internal air pressure is reduced, is then stirred and prepares.
Above-mentioned liquid glycerine includes plant extracts.
Above-mentioned plant extracts containing 2~5 percentage by weights.
Grape (Vitis vinifera), tea tree (Camellia sinensis) are used as above-mentioned plant extracts, are got over
Tangerine (Vaccinium sp.), black fruit blueberry (Vaccinoum myrtillus), the garment or robe made of feathers careless (Alchemilla vulgaris),
A kind of extract solution in sensitive plant (Mimosa tenuiflora), Echinacea (Echinacea purpura).
Wherein it is preferred in the present invention, contain the upper of 10 percentage by weights in the liquid glycerine of 90 percentage by weights
State collagen.
Therefore, active hypertonicity composition discharges exudate by glycerine from wound interior, and is arranged to external discrete
Go out microorganism and other polluters of wound, to make the inside of wound become clean, so as to promote the treatment of wound.
For the microorganism discharged to external discrete and the exudate of polluter, the vanilla enriched using OPC is carried
Take liquid to adsorb, to prevent above-mentioned exudate from internally flowing into again, and suppress to destroy the proteolytic enzyme of matrix in iuntercellular,
To neutralize their activity, so as to breed matrix in iuntercellular, thus promote treatment.
Above-mentioned collagen is the white clear being made up of multiple glycoprotein molecules as the structural proteins for forming extracellular matrix
Without branch's fibrillation, the monomer of collagen is precollagen, and procollagen molecule is formed by very thin and long spirality chain, with electricity
The a diameter of 1.5nm of sub- microscope, length are about 300nm, relative molecular mass is 2.85 × 105, empty by stable triple helices
Between structure special acid form.
Above-mentioned collagen is as the protein for carrying out to be formed conjunctive tissue between connection cell and cell with muscle, with iuntercellular base
The mode of matter is present, and occupies 25% to 35% in the protein for forming body, exists as fibroplastic protein
In fibr tissues such as such as tendon, ligament, skins.
Above-mentioned collagen is containing specific proteins much in skin or cartilage.Water is not dissolved in, and is added in water
Heat and extract, if carrying out heating extraction, collapse stereochemical structure, so as to being referred to as the denatured protein of gelatin, i.e. to have
As the property of solid when turning into liquid when being heated, and being cooled down.
Therefore, when the wound coated on skin, above-mentioned collagen makes the cell of skin and cell combine to improve skin
Thickness, and suppress the moisture evaporation of skin, there is anastalsis, low antigenicity, disintegrative and biocompatibility, pass through promotion
Clinical hemostasis and cell growth promote Wound healing and bone regeneration.
Table 1
As shown in Fig. 1 photo, it is made up of in the wound of patients with bedsore with 1g thickness coating embodiment 1 to embodiment 3
The invention formulation of gel-forming treated.
As a result, in the bedsore position for starting treatment using general treatment agent, wound location after coating 1 time, 10 days for 1 day
The state of deterioration is presented on the contrary, 3 results for treating 7 weeks are being coated within 1 week using invention formulation, although wound location
Scar is left, but presents and thoroughly cures.
Also, as shown in Fig. 2 photo, invention formulation is applied to be controlled with 1g thickness in the wound of patients with bedsore
Treat.
As a result, in the bedsore position for starting treatment using general treatment agent, wound location after coating 1 time, 10 weeks for 1 day
The state of deterioration is presented on the contrary, still, using invention formulation treatment in the 4 weeks result of 4 times, wound location does not almost leave wound
Trace, and substantially cured.
Also, as shown in Fig. 3 photo, invention formulation is applied to be controlled with 1g thickness in the wound of patients with bedsore
Treat.
As a result, in the bedsore position for starting treatment using general treatment agent, wound is presented after coating 1 time, 1 week within 1 day
The state that position is largely treated, still, coated within 1 week 2 times using invention formulation, carry out within 5 weeks 10 treatments, its
As a result, do not cured thoroughly in wound location, but the result almost cured.
Then, as shown in Fig. 4 photo, invention formulation is applied to be controlled with 1g thickness in the wound of fire victim
Treat.
As a result, in the burned part for starting treatment using general treatment agent, wound is presented after coating 1 time, 12 weeks within 1 day
The state that position is largely treated, still, coated within 1 week 2 times using invention formulation, carry out within 5 weeks 10 treatments, its
As a result, almost thoroughly cured in the wound location treated using general treatment agent, but utilizing present invention system
, can during starting treatment using above-mentioned general treatment agent and compared with number in the case that agent starts the burn wound for the treatment of
Know and cured within the quickish time.
Therefore, by above-mentioned Fig. 1 to Fig. 4, the wound of bedsore and burned part is entered using the invention described above preparation
Row treatment is not only cured compared with carrying out treatment using general treatment agent within the quickish time, and in wound portion
Position does not almost leave scar and treats totally.
There are the following problems in the prior art：Saline solution is only mixed in collagen to be nearly in contact with wound surface,
So as to only be used as styptic, the Shortcomings point in the effect for promoting Wound healing, also, moisture easily evaporates, because
This air barrier effect is low, and it is low pain remission effect to be present, and easily dries, and the present invention can solve the base of this existing issue
Used on plinth.
Claims (2)
1. a kind of skin wound therapeutic combination, it is characterised in that under normal temperature condition, in the plant containing 2~5 percentage by weights
In the liquid glycerine of 50~95 percentage by weights of thing extract mix 5~50 percentage by weights powdered collagen and group
Into.
2. skin wound therapeutic combination according to claim 1, it is characterised in that above-mentioned plant extracts be grape,
A kind of extract solution in tea tree, blueberry, black fruit blueberry, garment or robe made of feathers grass, sensitive plant, Echinacea.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150116661A KR101649450B1 (en) | 2015-08-19 | 2015-08-19 | Skin wound healing composition |
| KR10-2015-0116661 | 2015-08-19 | ||
| PCT/KR2016/009107 WO2017030388A1 (en) | 2015-08-19 | 2016-08-18 | Composition for treating skin wounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107427561A true CN107427561A (en) | 2017-12-01 |
Family
ID=56874658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680019591.4A Pending CN107427561A (en) | 2015-08-19 | 2016-08-18 | Skin wound therapeutic combination |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101649450B1 (en) |
| CN (1) | CN107427561A (en) |
| WO (1) | WO2017030388A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109364086A (en) * | 2018-11-28 | 2019-02-22 | 福建师范大学 | The method that hypertonic glycerol pretreatment improves aminoglycoside antibiotics germicidal efficiency |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101904196B1 (en) | 2017-04-18 | 2018-10-04 | 이상철 | Skin wound healing composition |
| CN108125903A (en) * | 2018-01-19 | 2018-06-08 | 深圳光彩生命工程技术有限公司 | A kind of novel stem cells composite factor anti-aging cosmetics |
| KR102292114B1 (en) * | 2020-11-13 | 2021-08-20 | 주식회사 피에프네이처 | Composition for Improving Skin Conditions Having Moisturizing, Anti-Inflammatory Caused by Fine Dust and Pore Shrinkage Property Comprising Plant Complex Extracts as Active Ingredient |
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| US7910135B2 (en) * | 2006-10-13 | 2011-03-22 | Uluru Inc. | Hydrogel wound dressing and biomaterials formed in situ and their uses |
| KR20100030031A (en) * | 2008-09-09 | 2010-03-18 | 한스바이오메드 주식회사 | Human skin regenerative powder from alloskin source |
| KR20110102811A (en) * | 2010-03-11 | 2011-09-19 | 이상철 | Medical treatment of composite |
| KR101296754B1 (en) * | 2010-08-13 | 2013-08-20 | 신현우 | A Hydrogel Composition For Transdermal Administration of Drug |
| CA2867260C (en) * | 2012-03-14 | 2021-10-05 | Amy Debra ROSENBLUH | Methods and compositions of combined herbal extract for treatment of disease |
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2015
- 2015-08-19 KR KR1020150116661A patent/KR101649450B1/en active IP Right Grant
-
2016
- 2016-08-18 WO PCT/KR2016/009107 patent/WO2017030388A1/en active Application Filing
- 2016-08-18 CN CN201680019591.4A patent/CN107427561A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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Also Published As
| Publication number | Publication date |
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| WO2017030388A1 (en) | 2017-02-23 |
| KR101649450B1 (en) | 2016-08-18 |
| WO2017030388A9 (en) | 2018-03-01 |
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