CN114392324A - Bletilla striata medicine for treating burns and scalds and preparation method thereof - Google Patents
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Abstract
The invention provides a bletilla striata burn and scald medicine and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The preparation method of the bletilla striata medicine for treating burns and scalds, provided by the invention, comprises the following steps: (1) drying and crushing the bletilla striata to obtain superfine bletilla striata powder; (2) mixing the superfine rhizoma bletillae powder with the oil solution matrix to obtain the rhizoma bletillae oil solution for treating burns and scalds; or mixing the superfine powder of rhizoma Bletillae with the paste matrix to obtain rhizoma Bletillae paste for treating burn and scald. The bletilla striata burn and scald medicine provided by the invention has no irritation when being applied, has a good pain relieving effect, can avoid external irritation and bacterial infection, can improve local blood circulation, is beneficial to wound regeneration, and has the advantages of simple and convenient preparation process, low cost and wide application prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a bletilla striata burn and scald medicine and a preparation method thereof.
Background
Burn and scald are common surgical wounds in daily life, and the wounds bring certain damage to the spirit and the body of people and bring inconvenience to daily life. Burn and scald are accompanied by red, swelling and burning pain, and the wound is easy to be infected and suppurated, so that the severity of the wound is aggravated and even scars are left after poor treatment. Therefore, the key points of treating the burns and scalds are two aspects of the antibiosis and the antiphlogosis of the wound surface and the promotion of the wound surface healing.
The traditional Chinese medicine bletilla striata is a dried tuber of a perennial herb bletilla striata of the family Orchidaceae. In the field of traditional Chinese medicine, common bletilla pseudobulb compound is mostly adopted for treating burns and scalds, for example, patent CN105456722A discloses a compound burn and scald medicine prepared from lithospermum, giant knotweed rhizome, gardenia, phellodendron, garden burnet, common bletilla pseudobulb and borneol; patent CN102228623A discloses a compound burn and scald medicine prepared from sanguisorba, bletilla, callicarpa bodinieri, rheum officinale, polygonum cuspidatum, scutellaria barbata and lithospermum. But the application of the traditional Chinese medicine composition to white and single-prescription treatment of burns and scalds is less, and no medicament for treating the burns and scalds by using the common bletilla pseudobulb single-prescription is available. Aiming at the defect, the invention researches the white and single-component treatment of burns and scalds, and aims to provide a simple, noninvasive, safe and effective bletilla striata burn and scald medicine.
Disclosure of Invention
The invention provides a non-invasive, safe and effective rhizoma bletillae burn and scald medicine and a preparation method thereof. The bletilla striata burn and scald medicine provided by the invention is simple and convenient in preparation process, safe to use, capable of avoiding external stimulation and bacterial infection, improving local blood circulation, beneficial to wound regeneration, low in cost and wide in application prospect.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a preparation method of a bletilla striata medicine for treating burns and scalds, which comprises the following steps:
(1) drying and crushing the bletilla striata to obtain superfine bletilla striata powder;
(2) mixing the superfine rhizoma bletillae powder with the oil solution matrix to obtain the rhizoma bletillae oil solution for treating burns and scalds; or mixing the superfine powder of rhizoma Bletillae with the paste matrix to obtain rhizoma Bletillae paste for treating burn and scald.
Preferably, the drying temperature in the step (1) is 60-75 ℃, and the drying time is 7-10 h;
preferably, the particle size of the bletilla striata ultrafine powder is 200-300 meshes.
Preferably, the mass ratio of the bletilla striata ultrafine powder to the oil agent matrix is 1: 1-2.
Preferably, the oil base comprises one or more of sesame oil, soybean oil and sesame oil.
Preferably, the mass ratio of the bletilla striata ultrafine powder to the paste matrix is 1-2: 2-4.
Preferably, the ointment base comprises one or more of vaseline, beeswax and lanolin.
Preferably, the bletilla striata ultrafine powder and the paste matrix are mixed for 0.5-1.5 h at 65-80 ℃.
The invention also provides a bletilla striata burn and scald medicine.
The invention provides a preparation method of a bletilla striata burn and scald medicine, which is characterized in that bletilla striata ultrafine powder and an oil agent matrix are mixed to prepare the bletilla striata oil agent burn and scald medicine, and the bletilla striata ultrafine powder and an ointment matrix are mixed to prepare the bletilla striata ointment burn and scald medicine. The burned skin is usually dry, and the ointment matrix and the oil matrix can keep the wound surface moist and prevent chapped skin. The ointment matrix can form a protective film on the surface of the wound to prevent bacteria from invading, and the rhizoma bletillae has an antibacterial effect, so that the infection of the wound can be prevented by combining the rhizoma bletillae and the ointment matrix, and the burn and scald can be effectively treated.
The bletilla striata burn and scald medicine provided by the invention has good functions of astringing to stop bleeding, reducing swelling and promoting granulation, can be clinically used for treating diseases such as epidermal burn and scald, and has the advantages of short scabbing and healing period, ordered cell arrangement under tissue slices and better anti-inflammatory effect. The selected medicinal materials are wide in planting, easy to obtain, low in price, simple in preparation process and good in stability, the prepared rhizoma bletillae medicine for treating burns and scalds is nonirritating in application, has a good pain relieving effect, can avoid external stimulation and bacterial infection, can improve local blood circulation, is beneficial to wound regeneration, is suitable for clinical popularization and application, and has a wide application prospect.
Drawings
FIG. 1 is a dry bletilla striata after drying in example 1;
FIG. 2 is the bletilla striata micropowder prepared in example 1;
FIG. 3 is the bletilla striata oil burn and scald agent prepared in example 1;
FIG. 4 shows the bletilla striata ointment burn and scald medicine prepared in example 3;
FIG. 5 shows the bletilla striata oil burn and scald medicine (right picture) and the bletilla striata paste burn and scald medicine (left picture) stored in a sealed manner in example 1 and example 3;
FIG. 6 shows the healing conditions of III-grade burn and scald wound surfaces of rats in a blank group, an ointment group, an oil agent group and a positive control group;
FIG. 7 shows the effect of the blank group, the ointment group, the oil agent group and the positive control group on pathological changes of the skin tissues of the rats with III-grade burns and scalds after being taken for 7 days;
FIG. 8 shows the effect of the blank group, the ointment group, the oil agent group and the positive control group on the pathological changes of the skin tissues of the rats with the grade III burns and scalds after being taken for 20 days.
Detailed Description
The invention provides a preparation method of a bletilla striata medicine for treating burns and scalds, which comprises the following steps:
(1) drying and crushing the bletilla striata to obtain superfine bletilla striata powder;
(2) mixing the superfine rhizoma bletillae powder with the oil solution matrix to obtain the rhizoma bletillae oil solution for treating burns and scalds; or mixing the superfine powder of rhizoma Bletillae with the paste matrix to obtain rhizoma Bletillae paste for treating burn and scald.
The invention dries and crushes the bletilla striata to obtain the bletilla striata superfine powder.
In the present invention, the bletilla striata is preferably fresh, fleshy, plump and pest-free bletilla striata tubers.
In the present invention, it is preferable that the bletilla striata is washed before the whitening and drying, and after the washing, the whitening and drying is preferably performed by wiping with a filter paper.
In the present invention, the number of washing is preferably 3 to 8, more preferably 4 to 7, and still more preferably 5.
In the present invention, it is also preferable to cut the cleaned rhizoma bletillae tubers into slices.
In the invention, the drying temperature is preferably 60-75 ℃, more preferably 63-70 ℃ and still more preferably 65 ℃.
In the invention, the drying time is preferably 7-10 h, more preferably 8-9 h, and still more preferably 8.5 h.
And after drying, obtaining the dried rhizoma bletillae. Pulverizing dried rhizoma Bletillae to obtain rhizoma Bletillae micropowder.
In the present invention, the pulverization is preferably carried out using a micronizer.
In the invention, the particle size of the bletilla striata ultrafine powder is preferably 200-300 meshes, more preferably 230-280 meshes, and still more preferably 240 meshes.
After the bletilla striata ultrafine powder is prepared, the bletilla striata ultrafine powder is mixed with an oil agent matrix to obtain the bletilla striata oil agent burn and scald medicine.
In the invention, the mass ratio of the bletilla striata ultrafine powder to the oil agent matrix is preferably 1: 1-2, more preferably 1: 1.
in the invention, the oil agent matrix is preferably one or more of sesame oil, soybean oil and sesame oil, and is more preferably sesame oil.
After the superfine bletilla striata powder is prepared, the superfine bletilla striata powder is mixed with the paste matrix to obtain the bletilla striata paste burn and scald medicine.
In the invention, the mass ratio of the bletilla striata ultrafine powder to the paste matrix is preferably 1-2: 2-4, and more preferably 1: 1-2, and still more preferably 1: 2.
in the present invention, the cream base is preferably one or more of vaseline, beeswax and lanolin, and further preferably vaseline. The petrolatum is preferably medical petrolatum.
In the present invention, the mixing of the fine bletilla powder and the paste base is preferably carried out in a water bath.
In the invention, the temperature of the water bath is preferably 65-80 ℃, more preferably 70-78 ℃ and even more preferably 75 ℃.
In the invention, the time of the water bath is preferably 0.5-1.5 h, and more preferably 1 h.
The invention also provides a bletilla striata burn and scald medicine, which is preferably prepared according to the preparation method.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
A rhizoma Bletillae oil preparation for treating burn and scald is prepared by the following steps:
first step, material selection: taking fresh, fleshy, plump and insect-free rhizoma bletillae tubers.
And a second step of cleaning and drying: washing rhizoma Bletillae tuber with clear water for 5 times, and wiping with filter paper. Cutting cleaned rhizoma Bletillae tuber into pieces, and oven drying at 65 deg.C for 7 hr to obtain dried rhizoma Bletillae (shown in figure 1).
The third step is crushing: pulverizing dried rhizoma Bletillae into 240 mesh micropowder to obtain rhizoma Bletillae micropowder (shown in figure 2).
And step four, mixing: soaking rhizoma Bletillae micropowder in sesame oil of equal mass, stirring to obtain rhizoma Bletillae oil preparation for treating burn and scald (as shown in figure 3), and sealing for storage (as shown in figure 5 right).
The application method of the bletilla striata oil burn and scald medicine comprises the following steps:
the medicine is applied to affected part 1 time a day by soaking cotton swab and rhizoma Bletillae oil on affected part according to skin injury size and position.
Example 2
A rhizoma bletillae ointment burn and scald medicine for treating burns and scalds is prepared by the following steps:
first step, material selection: taking fresh rhizoma Bletillae tubers which are fleshy, plump and free of insect damage.
And a second step of cleaning and drying: washing rhizoma Bletillae tuber with clear water for 4 times, and wiping with filter paper. Cutting cleaned rhizoma bletilla tuber into pieces, drying in a drying oven at 70 deg.C for 10 hr, and drying to obtain dried rhizoma bletilla.
The third step is crushing: and (3) putting the dried bletilla striata into an ultrafine grinder to be ground until the particle size is 240 meshes, so as to obtain the bletilla striata ultrafine powder.
And a fourth step of decoction: adding medical vaseline with equal mass into the rhizoma bletilla superfine powder, mixing, heating in water bath at 70 deg.C for 1 hr, mixing to obtain rhizoma bletilla paste, and sealing in container.
The rhizoma Bletillae ointment burn and scald medicine is applied to the affected part according to the size and position of skin injury, and the application dose is 1 time per day, just covering the affected part.
Example 3
A rhizoma bletillae ointment burn and scald medicine for treating burns and scalds is prepared by the following steps:
first step, material selection: taking fresh rhizoma Bletillae tubers which are fleshy, plump and free of insect damage.
And a second step of cleaning and drying: washing rhizoma Bletillae tuber with clear water for 8 times, and wiping with filter paper. Cutting cleaned rhizoma bletilla tuber into pieces, drying in a drying oven at 65 deg.C for 8 hr, and drying to obtain dried rhizoma bletilla.
The third step is crushing: and (3) putting the dried bletilla striata into an ultrafine grinder to be ground until the particle size is 300 meshes, so as to obtain the bletilla striata ultrafine powder.
And a fourth step of decoction: adding 2 times of medical vaseline into rhizoma Bletillae micropowder, mixing, heating in 75 deg.C water bath for 0.5 hr, mixing to obtain rhizoma Bletillae paste (as shown in figure 4), and sealing in container (as shown in figure 5 left).
The rhizoma Bletillae ointment burn and scald medicine is applied to the affected part according to the size and position of skin injury, and the application dose is 1 time per day, just covering the affected part.
Experimental example 1
The influence of the bletilla striata burn and scald medicine on the scald wound surface of a rat
(1) Establishing a rat skin trauma model:
the experiment was conducted in a university of medical compliance laboratory.
64 male SD rats with the weight of 200 g-250 g are selected and are adaptively fed in a well-ventilated feeding room with the room temperature constant at 25 ℃ for one week. One week later, the rats were dehaired on their backs with an 8% sodium sulfide solution, and the area of dehairing was 4cm × 6 cm. After 24h, the anesthesia treatment was carried out with diethyl ether. After the asbestos cardboard was wetted, a square hole of 2cm × 2cm was cut out with a blade in the center. Covering the back of the rat, and exposing the area of the scald-simulating part from the hole. Setting the temperature of the constant-temperature electric iron to be 80 ℃, preheating, contacting the constant-temperature electric iron with the exposed skin for 8s, timing by a stopwatch, and removing the constant-temperature electric iron after the time to obtain a rat III-level burn and scald model.
(2) The rats with scald are randomly divided into 4 groups, each group comprises 16 rats, including a blank group, an ointment group, an oil agent group and a positive control group, and are raised in cages. Wherein the oil agent group adopts the bletilla striata oil agent burn and scald medicine prepared in the embodiment 1; the rhizoma bletillae ointment prepared in example 3 was used as the ointment group; the positive control group used commercially available Meibao moist burn cream from Meibao pharmaceutical Co., Ltd.
The medicine is not applied to the blank group, the other three groups are applied after scald for 0.5h, the application area is just covered on the affected part, the thickness is 1mm, and the medicine is applied once a day. The application was continued until the wound healed, during which the number of scab days, number of decrustation days and number of healing days were recorded for each group, and the results are shown in table 1. The healing status of the scald on days 1, 3, 7, 15 and 20 was recorded by photographing, as shown in fig. 6.
TABLE 1 healing of III-grade burn and scald in rats
| Group of | Number of scab formation days | Number of days to decrustation | Days of healing |
| Blank group | 6.40±0.48 | 18.75±2.24 | 30.40±2.06 |
| Paste composition | 4.40±1.01 | 16.80±1.49 | 24.80±2.22 |
| Oil agent group | 4.20±0.74 | 15.80±1.72 | 27.60±2.05 |
| Positive control group | 3.40±0.80 | 15.00±1.41 | 26.40±2.57 |
As can be seen from table 1, compared to the blank group, the ointment group, the oil group, and the positive control group had shorter scabbing, and healing time and faster speed. Wherein, the positive control group has the fastest scabbing and scabbing speed, and the oil agent group has the second, the paste group is relatively slow; but the paste group healed the fastest, the oil group the second, the positive control group was relatively slow.
As can be seen from fig. 6, compared to the blank group, the ointment group, the oil agent group, and the positive control group had faster healing of the burn and scald and smaller wound area.
In the experiment, one rat is randomly selected from each group to be killed on the 7 th day, a back scald tissue section is taken to be subjected to He staining, and the treatment effect of each group of drugs on the third-level burn skin tissue of the rat is observed, as shown in fig. 7; one rat was randomly selected from each group on day 20 to be sacrificed and dorsal scald tissue sections were taken for He staining, and the therapeutic effect of each group of drugs on rat class III scald skin tissues was observed, as shown in fig. 8.
As can be seen from fig. 7, when the wound tissue sections were observed on day 7, a large amount of new capillaries were generated in the ointment group, the oil group, and the positive control group, and the granulation tissue was arranged more orderly with a large amount of inflammatory cell infiltration. Wherein, the cells under the tissue slices of the paste group are arranged closely and more orderly, and the observation of the number of the new capillaries and the infiltrative inflammatory cells is more obvious, which shows that the recovery effect and the anti-inflammatory effect of the paste group are better than those of the other groups.
As can be seen from fig. 8, when the wound tissue sections were observed on day 20, the cells were closely and more orderly arranged under the tissue sections of the ointment group, the oil group, and the positive control group, compared to the blank group. Wherein, the treatment effects of the ointment group and the oil group are not obviously different from the treatment effects of the positive control group.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. The preparation method of the bletilla striata medicine for treating burns and scalds is characterized by comprising the following steps of:
(1) drying and crushing the bletilla striata to obtain superfine bletilla striata powder;
(2) mixing the superfine rhizoma bletillae powder with the oil solution matrix to obtain the rhizoma bletillae oil solution for treating burns and scalds; or mixing the superfine powder of rhizoma Bletillae with the paste matrix to obtain rhizoma Bletillae paste for treating burn and scald.
2. The preparation method according to claim 1, wherein the drying temperature in the step (1) is 60-75 ℃, and the drying time is 7-10 h.
3. The preparation method of claim 2, wherein the particle size of the bletilla striata micropowder is 200-300 meshes.
4. The preparation method according to claim 3, wherein the mass ratio of the bletilla striata micropowder to the oil agent matrix is 1: 1-2.
5. The method of claim 4, wherein the oil base comprises one or more of sesame oil, soybean oil, and sesame oil.
6. The preparation method of claim 5, wherein the mass ratio of the bletilla striata micropowder to the paste base is 1-2: 2-4.
7. The method of claim 6, wherein said ointment base comprises one or more of petrolatum, beeswax and lanolin.
8. The preparation method according to any one of claims 1 to 7, wherein the fine bletilla striata powder is mixed with the paste base at 65 to 80 ℃ for 0.5 to 1.5 hours.
9. A bletilla striata burn and scald medicine obtained by the preparation method of any one of claims 1 to 8.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115844994A (en) * | 2022-12-29 | 2023-03-28 | 遵义医科大学 | Rhizoma bletillae ointment and preparation method and application thereof |
| CN115970047A (en) * | 2023-01-28 | 2023-04-18 | 贵州省农作物品种资源研究所 | Preparation method of bletilla striata gel freeze-dried powder, and dry powder solid dressing and liquid dressing containing bletilla striata freeze-dried powder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115844994A (en) * | 2022-12-29 | 2023-03-28 | 遵义医科大学 | Rhizoma bletillae ointment and preparation method and application thereof |
| CN115844994B (en) * | 2022-12-29 | 2024-02-02 | 遵义医科大学 | Bletilla striata ointment and preparation method and application thereof |
| CN115970047A (en) * | 2023-01-28 | 2023-04-18 | 贵州省农作物品种资源研究所 | Preparation method of bletilla striata gel freeze-dried powder, and dry powder solid dressing and liquid dressing containing bletilla striata freeze-dried powder |
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