CN107693714A

CN107693714A - A kind of Chinese medicine composition for repairing face skin care and its preparation method and application

Info

Publication number: CN107693714A
Application number: CN201711035206.8A
Authority: CN
Inventors: 万忠秀
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-10-30
Filing date: 2017-10-30
Publication date: 2018-02-16

Abstract

The present invention relates to field of medicaments, more particularly to a kind of Chinese medicine composition for repairing face skin care and its preparation method and application, the Chinese medicine composition is made up of the medicine of following parts by weight：15 25 parts of black false hellebore, 15 25 parts of sweet wormwood, 15 25 parts of straw, 15 25 parts of buckwheat bar, 15 25 parts of eggplant bar, 20 30 parts of Chinese waxgourd stem, 20 30 parts of mulberry bavin, 20 30 parts of purslane, 30 50 parts of green salt, 30 50 parts of lime, 40 50 parts of folium artemisiae argyi；The present invention passes through reasonable compatibility, it is prepared by scientific method, make its product efficacy stability, the efficacy of a drug rapid, easy to use, quick, evident in efficacy, it is rotten except disliking, move back black, expelling pus and promoting granulation, repair face skin care and other effects with going, there is good result in terms of melanotic nevus knurl, senile plaque expelling, thorn monkey, flat wart, yellow face wart is dispelled, and have no toxic side effect；Pass through the interaction between effective active composition so that drug availability is high, and synergistic therapeutic action can perform to most preferably.

Description

A kind of Chinese medicine composition for repairing face skin care and its preparation method and application

Technical field

The present invention relates to field of medicaments, more particularly to a kind of Chinese medicine composition for repairing face skin care and preparation method thereof and should With.

Background technology

Mole is the most common benign skin tumour of the mankind, is epidermis, cutaneous manifestations caused by intradermal melanocytosis, Person in middle and old age, child can occur, and usually influence attractive in appearance, and a few peoples can unhealthful generation canceration.Seborrheic keratosis (SK) senile wart, senile plaque expelling, basal cell papilloma, and a kind of clinical most common benign skin tumour, good hair are also known as It is the epidermis hyperplasia of prostate because caused by keratinocyte hyperplasia in the elderly.And due to HPV viruse infection it is flat A kind of common skin problem of wart and puzzlement younger population, it is general that color of the leather or pink is presented, without obvious subjective symptoms, Thorn monkey (i.e. verruca vulgaris, plantar wart, verruca vulgaris) caused by same virus infection, and growing in circumocular yellow face wart etc., due to than It is more eye-catching, prominent, and the same with flat wart worry can also be brought by directly or indirectly contagion.With epithelium Skin disease, in addition to maligna element mole knurl can also pose a health risk, general benign nevus knurl, flat wart, thorn monkey, senile plaque expelling, yellow face wart It though Deng being not what serious disease, can influence attractive in appearance, and bring many inconvenience to Working Life.

There is the methods of many beauty and shaping institutes can typically use laser, freezing, surgery excision on the market at present, either The methods of being smeared with lime, caustic soda, refuse battery, bamboo stick puncture, potato peel, but the either physics such as laser, freezing, surgery excision Method, or the method for skin is burnt with alkaline matter, rigid injury is not only caused to illing skin, not paying attention to slightly also can be to week Enclose skin to damage, or even illing skin also can scar either hollow, skin be rough smooth etc. after treatment.Cause This, for the consideration of health and safety, it is particularly important to work out no allergy, pure Chinese medicine product that is nontoxic, having no side effect.

In existing patented technology, the prescription for acting on various disease of skin especially mole, senile plaque expelling, wart etc. is not rare. As patent No. CN200710198560.2 discloses a kind of Chinese medicine preparation of eliminating naevus and color spot, by lime, borneol, turmeric, food With alkali, spermaceti base glucoside, alcohol according to a certain percentage with appropriate distilled water is processed is prepared, the Chinese medicine preparation energy Eliminating naevus, freckle, senile plaque expelling, hemangioma etc..Corrosiveness of the party based on alkaline matter, and other medicinal materials it is clearing heat and detoxicating, The effect of broken analgesic of becoming silted up, but after being eroded to surface skin layer, it is no in terms of skin histology reparation to deepen research.

And for example patent No. CN200510046930.1 disclose it is a kind of be used to treating various plano-convex naevus moles, freckle, senile plaque expelling, The naevus removing ointment of flat wart, wart etc., its weight proportion are lime 45-55%；50 degree of level above white wine 35-45%；Yunnan is white Medicine 8-14%, minium 3-7%.It is broken that the party using lime takes epiderm skin, white using Yunnan using high spirit sterilizing Medicine and minium anti-inflammatory, but first lime dosage accounting it is big after, easy misoperation and cause scar and hole, second promote skin It is short of in terms of tissue repair, U.S. face myogenic.

And for example patent No. CN200410014064.3 disclose treatment corn, foot pad, thorn monkey and ecphyma external used medicine and Preparation method, raw material composition：Buckwheat, alum, ginkgo leaf, centipede, snake slough, full crab, sulfur, unprocessed Arisaema erubescens, fresh grass Wheeling, wind Magnificent lime, white mulberry wood-ashes.At the therapeutic effect of the specification, the prescription corrosion strength is strong, in addition flesh after slough softening and shedding Skin is voluntarily to regenerate, and has no the auxiliary such as rush tissue repair, U.S. flesh and repaiies face effect；For another example patent No. CN201510811274.3 is disclosed Oriental wormwood giant knotweed ointment agent and preparation method thereof, is mixed with the Chinese medicinal material extracts such as oriental wormwood, sweet wormwood, giant knotweed, the root of Dahurain angelica and tea oil, beeswax System forms, and the ointment is applied to various burns, scald, has antibacterial, life, anti-inflammatory, goes corruption, analgesic is rapid, wound healing soon, After recovery from illness the features such as preventing from scar.But can not refer to act on the skin problems such as mole wart, senile plaque expelling, wart.

Although above patent or report provide many can treat or dispel hemorrhoid, flat wart, the prescription of senile plaque expelling or production Product, but majority is to cure mainly its any illness and alleviate other symptoms, or remove slough and lack face, the effect of U.S. flesh of repairing, or Person is the effect that only promoting healing does not stay scar, and is had to melanotic nevus knurl, senile plaque expelling, thorn monkey, flat wart, yellow face wart simultaneously Effect, and take into account detumescence relieve the pain, antibacterial sterilization, the medicine of U.S. face myogenic it is relatively fewer, and the trend of future development.And in Yunnan-Guizhou Deng the characteristic medicine of minority area, these diseases are treated using the special formula passed on for many years, there is spy Other effect.

The content of the invention

In order to solve the above technical problems, characteristic medicine and therapy of the present invention using minority areas such as Yunnan-Guizhou, with reference to The pathogenesis of tcm theory and mole knurl, wart, senile plaque expelling etc., there is provided a kind of Chinese medicine composition for repairing face skin care and its preparation Methods and applications.

The present invention is achieved by the following technical programs：

A kind of Chinese medicine composition for repairing face skin care, it is characterised in that：The Chinese medicine composition by following parts by weight medicine It is made：Black false hellebore 15-25 parts, sweet wormwood 15-25 parts, straw 15-25 parts, buckwheat bar 15-25 parts, eggplant bar 15-25 parts, Chinese waxgourd stem 20-30 Part, mulberry bavin 20-30 parts, purslane 20-30 parts, green salt 40-50 parts, lime 40-50 parts, folium artemisiae argyi 40-50 parts.

Further, the Chinese medicine composition is calculated as by weight：20 parts of black false hellebore, 20 parts of sweet wormwood, 20 parts of straw, buckwheat bar 20 Part, 20 parts of eggplant bar, 25 parts of Chinese waxgourd stem, 25 parts of mulberry bavin, 25 parts of purslane, 45 parts of green salt, 45 parts of lime, 45 parts of folium artemisiae argyi.

The preparation method of foregoing is as follows：

1) formula ratio Chinese medicine is taken, in addition to lime, green salt, charing process after remaining 10 taste is dried, then grinding sieving is standby With；

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and add 75% alcohol, are placed 10-30 days after being sufficiently mixed, and send out Chinese medicine composition is produced after ferment.

Wherein, charing process is using the method carbonized in direct burning carbonate or high temperature service in the step 1)；Grind Wore into the fine powder of 60-100 mesh sieves.

Lime, green salt are ground into the particle that particle diameter is less than 0.5mm in the step 2).

It is under conditions of closed that fermentation is placed in the step 3), and 20-30 DEG C of environment temperature places 10-15 days, environment 10-20 DEG C of temperature places 15-20 days, placement 20-30 days of 0-10 DEG C of environment temperature.

The present invention the Chinese medicine composition for repairing face skin care, can with pharmaceutically acceptable auxiliary material, such as emulsifiable paste matrix, bleeding agent Deng using method known to medicines and health protection field, external preparation is made.

It is preferred that the preparation is paste, lotion, patch.

For example, the preparation method of paste is as follows：

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and add 75% alcohol, are placed 10-30 days after being sufficiently mixed, and send out Chinese medicine composition is produced after ferment；

4) aforesaid fermentation thing is added into appropriate amounts of gelatin, glycerine, vaseline or camellia oil, is modulated into cream, produces.

The invention also discloses foregoing Chinese medicine composition or its preparation to dispel melanotic nevus knurl, senile plaque expelling, thorn in preparation Application in monkey, flat wart, yellow face wart medicine.

Of the invention mainly to utilize local characteristic medicinal material, and agricultural waste gurry etc., its composite reagent has distinct place Characteristic, the pharmaceutical characteristic of each raw material that the present invention uses for：

Black false hellebore：It is grown in hillside sylvan life or the thick grass of height above sea level 1200-3300 rice, is Guizhou common drug among the people.Root And rhizome is used as medicine, can emetic, eliminating the phlegm, desinsection, cure mainly heap soil or fertilizer over and around the roots of apoplexy phlegm, epilepsy, larynx numbness etc.；Mange, malignant sore, desinsection maggot are controlled in external application.

Sweet wormwood：The provinces and regions such as main product Chongqing tenth of the twelve Earthly Branches sun, Guizhou, Yunnan are also common.Clear abnormal heat, cool blood is except steaming, relieving summer-heat, preventing malaria. Generated heat for summer-heat evil, fever due to yin deficiency, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills etc., external application removing toxic substances, control metal-inflicted wound and flutter damage.

Straw, buckwheat bar and eggplant bar：Be the stem of the plant, straw have with stomach, wide intestines, Li Shui, promote ulcer healing etc. and make With buckwheat stalk can have heat-clearing solution with the effect of collagen level, beautifying face and moistering lotion, also disinfection and anti-inflammation in keeping body, eggplant bar Poison, invigorating circulation of blood to dissipate blood stasis and reducing swelling and relieving pain and hemostasis and other effects.

Chinese waxgourd stem：Clearing lung and eliminating phlegm；It is clearing and activating the channels and collaterals.

Sang Chai：The effect of for the stem branch of moraceae plants mulberry, its ash burnt till has Li Shui, hemostasis, and meat is disliked in erosion.It is usually used in water It is swollen, metal-inflicted wound bleeding, mole defect on face.

Purslane：For field common weed.It is clearing heat and detoxicating, cooling blood and hemostasis.For hot dysentery purulence blood, heat gonorrhea, vaginal discharge diseases, carbuncle swells Malignant sore, erysipelas.

Folium artemisiae argyi：Warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin.

Green salt：With purge heat, cool blood, improving eyesight, moisturize the effect of；Hematuria is controlled, is spitted blood, radula bleeding, conjunctival congestion with ophthalmalgia, the eye of wind is rotten String, toothache.

Lime：Meat is disliked in eliminating dampness, desinsection, hemostasis, analgesic therapy, erosion.Mange is controlled, wet sore, traumatic bleeding, the burning hot wound of soup, hemorrhoid, is taken off Anus, wart.

To sum up, the beneficial effects of the present invention are：

1st, in terms of being formulated composition：In inventive formulation, meat, green salt, sweet wormwood, purslane and folium artemisiae argyi solution are disliked in lime, the erosion of mulberry bavin Malicious hemostasis, anti-inflammation, desinsection are antipruritic, black false hellebore, straw, buckwheat bar and eggplant bar swelling and pain relieving, wound healing and skin repair, Chinese waxgourd stem is clearing and activating the channels and collaterals.Therefore, the present invention recycles the mutual collaboration of composition to make based on the pharmacological action of each crude drug With, curative effect is improved, it is comprehensive to reach phagedenoma, sore, myogenic, repair the effect of face, skin care to adapt to the treatment requirement of the complicated state of an illness.

2nd, in terms of preparation method：Using first being carbonized to 9 kinds of medicinal materials such as black false hellebore, powdered carbon and lime etc. used into alcohol again Absorb, fermentation preparation method, folkd therapy and modern science and technology are blended, make full use of Chinese medicine carbonize after enhancing restrain, Clearing damp, hemostasis and reinforcement medicine warm the effect of property in itself, are easy to carbonize in conjunction with straw, eggplant bar, buckwheat bar and promote other The characteristics of composition ferments, alcohol is added afterwards and both avoids being easily caused bacteria breed and breeding during fermentation, and can is preferably slowly oozed Thoroughly with the dissolution of promotion active ingredient, to sum up, make dispelling thoroughly for mole knurl, and avoid the stimulation and injury to skin.

3rd, application aspect：The present invention passes through reasonable compatibility, prepared by scientific method so that product efficacy stability, the efficacy of a drug be rapid, It is easy to use, quick, evident in efficacy, have go it is rotten, except dislike, move back it is black, restrain myogenic, repair face skin care and other effects, to melanin The disease of skin such as mole knurl, senile plaque expelling, thorn monkey, flat wart, yellow face wart have good action effect.

The Chinese medicine composition of the present invention includes following content in research process：

First, recipe determination

The medicine of existing mole in use, it can be seen that have using lime, caustic soda, refuse battery etc. aggressive product, its The real injury to skin is very big, and the position meeting scar of careless slightly not only hemorrhoid, neighbouring skin can be also cauterized.And The Chinese medicines such as alone purslane, white mulberry wood-ashes, black false hellebore, it is found that simply " erosion malignant sore ", skin wound is difficult to heal, also easily hair sense Dye；Also need to consider the effect such as heat-clearing sterilization, disinfection and anti-inflammation, myogenic sore, skin care U.S. face, the effect that can be only achieved. Therefore, the present inventor is screened in the Chinese medicine and product with foregoing effect, makes full use of special medicinal material lamb's-quarters among the people Reed, eggplant bar and Sang Chai, in folium artemisiae argyi, sweet wormwood, golden cypress, peach bark, radix scutellariae, the capsule of weeping forsythia, the root of Dahurain angelica, mirabilite, Chinese gall, Chinese waxgourd stem, dent Screened in the medicinal materials such as amaranth, consider further that whether arrange in pairs or groups appropriate lime, soda ash, light-coloured vinegar, green salt or salt compounded of iodine, then use for reference eggplant bar The thinking of pernio can be removed, is screened in conjunction with straw, buckwheat bar, cornstalk, digua fig stem and leaf etc..

After preliminary screening, find using a certain amount of lime, green salt, Sang Chai, black false hellebore, purslane, collocation folium artemisiae argyi, wax gourd Rattan, sweet wormwood, straw, buckwheat bar and eggplant bar, the place of the depositions such as the skin pigments such as melanotic nevus, wart, senile plaque expelling is first carried out suitably Corrode, the diffusion and regeneration of preventing virus, melanocyte, then play remaining medicinal material anti-inflammation, desinsection it is antipruritic, detumescence stop Bitterly, the effect of clearing heat and detoxicating, the Huoluo powder stasis of blood, hemostasia and detumescence, synthesis, which reaches, dispels melanotic nevus knurl, senile plaque expelling, flat wart, yellow face The skin sore spots such as wart, thorn monkey, repair face skin care, U.S. face myogenic again.

Further, in terms of the dosage of bulk drug, the custom of medication among the people, the compatibility of medicinal material, toxicity etc. are considered Factor, based on lime and green salt dosage, attempt the 80%-120% that folium artemisiae argyi dosage is lime respectively, Chinese waxgourd stem, purslane, White mulberry wood-ashes difference dosage is the 40%-70% of lime, black false hellebore, sweet wormwood, straw, buckwheat bar, the 30%- that eggplant bar difference dosage is lime 50%, randomly select the checking that value point carries out curative effect, security, as a result find, select black false hellebore 15-25 parts, sweet wormwood 15-25 parts, Straw 15-25 parts, buckwheat bar 15-25 parts, eggplant bar 15-25 parts, Chinese waxgourd stem 20-30 parts, mulberry bavin 20-30 parts, purslane 20-30 parts, Green salt 40-50 parts, lime 40-50 parts, folium artemisiae argyi 40-50 parts, dispel melanotic nevus knurl, senile plaque expelling, flat wart, yellow face wart, thorn monkey And other effects can reach more than 85%, and safe to use, preventing from scar after wound healing, not aobvious heterochromatic, wherein 20 parts of black false hellebore, sweet wormwood 20 parts, 20 parts of straw, 20 parts of buckwheat bar, 20 parts of eggplant bar, 25 parts of Chinese waxgourd stem, 25 parts of mulberry bavin, 25 parts of purslane, 45 parts of green salt, lime 45 parts of 45 parts, folium artemisiae argyi best results, big single area, thickening property senile plaque expelling, large number of sheet of mole knurl or wart can be dispelled.

2nd, craft screening

In the prior art, the utilization to the active ingredients of medicinal materials in addition to lime, green salt is usually using direct drug injection, decocting Boil or ethanol extraction after the mode such as medication, to maximally utilise the active component of each medicine, we are respectively adopted decocting and boiled Alcohol infiltrates the modes such as after fermentation to the medicinal material after extraction, alcohol reflux extraction, burning carbonate plus after water mixing, burning carbonate It is processed, then so that the experiment mice of cutaneous melanoma is carried out as model, bamboo stick picking extract in its mole knurl Processing, each group mouse mole knurl is observed after 7 days improves situation.

As a result show, using first carrying out burning carbonates to 9 kinds of medicinal materials such as black false hellebore, powdered carbon is carried out into suction sending and receiving with alcohol again The preparation method of ferment, mouse mole knurl is dispelled thoroughly, and skin is without exception, situations such as festering, swelling and ache；Using water or ethanol The method of extraction, mouse mole knurl have residual scar or it is red and swollen situations such as, prompting may be irritating to the skin and injure；Simple charing Afterwards, mole knurl dispel not thoroughly, partly also have.Show the method using the present invention, can effectively get active ingredient in medicinal material, Increase the utilization rate of medicinal material.The method Inspiration Sources in white mulberry wood-ashes use (mulberry bavin ashing i.e. have the effect of hemostasis, erosion dislike meat), Recycle straw, eggplant bar, buckwheat bar to be easy to carbonize and promotees the effect of other compositions fermentation, addition alcohol had both avoided bacteria breed and numerous Grow, and can is preferably slowly permeated and promotes the dissolution of active ingredient, it is even more important that it is right after being used as medicine to avoid directly extraction The stimulation and injury of skin.

Further, the mode to charing, the dosage of alcohol, the time of fermentation screen, the results showed that, using direct The method carbonized in burning carbonate or high temperature service, wherein charing product were ground into the fine powder of 60-100 mesh sieves, lime, green grass or young crops Salt is ground into the particle that particle diameter is less than 0.5mm, carbonization power can be made to be sufficiently mixed with particle, and dilute strength is reasonable；Because stone After the particle and carbonization power particle diameter of ash and green salt are big, subsequent fermentation is incomplete, and mix between each composition of medicine it is uneven, Active component content can be caused uneven；And too thin one is easy moisture absorption caking, second, carbonization power proportion itself is lighter, and stone The particles such as ash are easier to cause powdered carbon in particles such as upper lime under when mixing, and will also result in the skewness of active component.Separately Outside, the alcohol that 1-3 times of raw material is measured is added, it is reasonable that raw material are infiltrated, while (20-30 DEG C of environment temperature under condition of different temperatures Place 10-15 days, 10-20 DEG C of environment temperature places 15-20 days, 0-10 DEG C of environment temperature places 20-30 days) carry out suction sending and receiving Ferment, the antibacterial and dissolution of alcohol work well.

3rd, effectiveness study

The present invention is studied its efficacy and saferry etc. respectively, is specifically shown in test example.As a result show using the present invention Paste, liniment or patch made by composition, total effective rate are more than 88.9%, are reached wherein dispelling melanotic nevus knurl effect 100%.Show, using composite preparation made of the pharmaceutical formulation and technique of the present invention, safely and effectively, to generally solve black Mole knurl, senile plaque expelling, flat wart, thorn monkey, caused by the disease of skin such as yellow face wart it is uncomfortable and safe and nontoxic, make without pair With.

Embodiment

Be described further below technical scheme, but claimed scope be not limited to it is described.

Embodiment 1

Product formula is following (so that 1000 doses of product is made in every side as an example)：

Embodiment 2：Preparation method of composition one

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and 75% alcohol of the quality such as raw material are added, after being sufficiently mixed Place 10-20 days, Chinese medicine composition is produced after fermentation.

Wherein, charing process is the method using direct burning carbonate in the step 1)；Then treat that carbide is cooled to After normal temperature, the fine powder of 60 mesh sieves was ground into.

It is under conditions of closed that fermentation is placed in the step 3), and 20-30 DEG C of environment temperature places 10 days, environment temperature 10-20 DEG C is placed 15 days, the placement 20 days of 0-10 DEG C of environment temperature.

Embodiment 3：Preparation method of composition two

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and 75% alcohol of 3 times of quality of raw material are added, after being sufficiently mixed Place 15-30 days, Chinese medicine composition is produced after fermentation.

Wherein, charing process is to use the method carbonized in high temperature service in the step 1)；Then treat that carbide cools down To normal temperature, the fine powder of 100 mesh sieves was ground into.

It is under conditions of closed that fermentation is placed in the step 3), and 20-30 DEG C of environment temperature places 15 days, environment temperature 10-20 DEG C is placed 20 days, the placement 30 days of 0-10 DEG C of environment temperature.

Embodiment 4：Preparation method of composition three

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and 75% alcohol of 2 times of quality of raw material are added, after being sufficiently mixed Place 12-25 days, Chinese medicine composition is produced after fermentation.

Wherein, charing process is using the method carbonized in direct burning carbonate or high temperature service in the step 1)；Grind Wore into the fine powder of 80 mesh sieves.

It is under conditions of closed that fermentation is placed in the step 3), and 20-30 DEG C of environment temperature places 12 days, environment temperature 10-20 DEG C is placed 18 days, the placement 25 days of 0-10 DEG C of environment temperature.

Embodiment 5：It is prepared by paste

1-8 formula in selection example 1, after being prepared according to any preparation method of composition of embodiment 2-4, it will ferment Thing adds appropriate amounts of gelatin, glycerine, vaseline or camellia oil, is modulated into cream, that is, every weight 15g paste is made.

Embodiment 6：It is prepared by lotion

1-8 formula in selection example 1, after being prepared according to any preparation method of composition of embodiment 2-4, it will ferment Thing adds appropriate purified water, 55%-70% ethanol solutions, sesame oil, camellia oil, coix seed oil, rapeseed oil or peanut oil, mixes It is even, every bottle of 20ml lotion is made.

Embodiment 7：It is prepared by patch

The formula of 1-8 in embodiment 1 is randomly choosed, will after being prepared according to any preparation method of composition of embodiment 2-4 Fermentate adds appropriate amount of fluid paraffin, lanolin, triethanolamine soap, sldium lauryl sulfate, polysorbate, gelatin, glycerine or all Intellectual circle, mix, every note weight 1.5g patch is made.

Test example 1：Stability and toxicity test

1st, preparation made from 5-7 of the embodiment of the present invention is subjected to accelerated stability investigation, be as a result shown in hot and humid etc. Under the conditions of product active constituent content of the present invention change it is little, appearance character does not also change, and various inspections meet country Drug standards requirement, but in embodiment low formula ratio (formula 7) active constituent content it is undesirable.

2nd, preparation made from 5-7 of the embodiment of the present invention carries out toxicological experiment research, by zoopery, it was demonstrated that each embodiment Obtained product is nonirritant to animal skin (in addition to formula 8), does not also occur allergic reaction, each group the weight of animals, diet and It is movable normal, it was demonstrated that small toxicity, to be very beneficial for Clinical practice.But the animal using product made from formula 10 has slight discomfort There is red and swollen phenomenon in phenomenon, a small number of animal cuticles, try occur scratch at painting, gradually recover normal after deactivation.It follows that using The high component of the present invention has certain toxicity, not recommended drug.

Experimental example 2：The pharmacodynamics test of the present composition and preparation

1st, test sample：Formula 1-3 in selection example 1, the method that embodiment 2-4 is respectively adopted in every kind of formula carry Take, be then added thereto 4 parts of addition camellia oils, 5 parts are added without, and totally 9 parts of sample is made；Formula 7-8 in selection example 1, Prepared according to the embodiment of the present invention 5, obtain 2 parts of sample；11 parts altogether.

Control sample 1：The formula that CN200410014064.3 embodiments provide, adds purified water that lotion is made；

Control sample 2：The formula that CN201510811274.3 embodiments provide, adds purified water that lotion is made.

2nd, content of the test：

2.1st, melanotic nevus wart evaluation test is dispelled：

Method：Choose health 56, are randomly divided into 13 groups：For examination 1-3 groups every group 12, for examination 7-8 groups and control 1,2 Group every group 5, benign melanocytic knurl model is established to each group rat, test sample and control sample are used respectively after modeling success Product are treated, and observe the change of mouse illing skin after treatment 1 day, after 3 days, after 7 days, after 10 days respectively.

2.2nd, the experiment of senile plaque expelling (seborrheic keratosis) evaluation of effect is dispelled：

Method：Mouse 56 is chosen, is randomly divided into 13 groups：For examination 1-3 groups every group 12, for 1,2 group of examination 7-8 groups and control Every group 5, seborrheic keratosis animal model is established by vitro skin grafting, after modeling successfully respectively with test sample and Control sample is treated, and observes the change of mouse illing skin after treatment 1 day, after 3 days, after 7 days, after 10 days respectively.

2.3 dispel flat wart, thorn monkey, the experiment of yellow face wart evaluation of effect：

Method：Mouse 168 is chosen, being randomly divided into 13 × 3 according to different skin problem respectively amounts to 39 groups (for examination 1-3 Group every group 12, for examination 7-8 groups and control 1,2 group every group 5), establish corresponding animal model, after model successfully respectively use confession Test agent and control sample are treated, and observe the change of mouse illing skin after treatment 1-3 days, after 7 days, after 2 weeks respectively.

2.4 result：

Using 9 parts of samples made of formula 1-3, mouse illing skin was darkened after 1-3 days or blackening, big after 7 days Part incrustation comes off, and skin surface color is desalinated after 2 weeks, without obvious scar, without the whole phenomenon of uneven, almost 9 after one month Group mouse skin is not different with its elsewhere.Not yet formed a scab and come off after 7 days using the mouse of comparative sample 1, color after 10 days It is also deep, slightly turn light after 2 weeks, but have some animals skin out-of-flatness bright and clean；Using the mouse of comparative sample 2, have no and dispel Mole wart, senile plaque expelling, flat wart, the effect for piercing monkey and yellow face wart.By the comparison with comparative sample, illustrate prescription of the present invention to black It is the function wells such as mole, senile plaque expelling, rapid, and take into account and repair face skin care effect.In addition, 7 groups of formula is that low amounts of components group is controlled With the effect of control sample 1 without difference, 8 groups of formula is high formula group therapeutic action with being formulated made of 1-3 9 parts for treatment effect Sample effect considers that it has certain excitant to skin without significant difference；Therefore, using amount ranges of the present invention, Function well.(result see the table below)

Clinical case of the present invention：

1st, Lee, female, 62 years old, left eye had about 0.5cm diameter melanotic nevus knurl one, and in August, 2017 is gone to a doctor in here, Given at mole wart the present invention lotion, dosage to coat mole wart, using 10 minutes or so it is rear i.e. alcohol swab wipe, then with fit Antiphlogistic powder is measured, being formed a scab after 7 days comes off, yellowish pink slightly deep, is no different after two weeks with the colour of skin.

2nd, Mr. Wang, male, 74 years old, cheek to temples had a fairly large number of senile plaque expelling, big diameter about 0.6cm, small pact 0.1cm, gone to a doctor in here at the beginning of 2017, the lotion of the present invention is given at senile plaque expelling, dosage is applied with coating senile plaque expelling Wiped with alcohol swab within 15 minutes or so, then with appropriate antiphlogistic powder, patch darkens after 7 days, and incrustation in 3-4 weeks or so comes off, 1 Gradually recover within individual month or so to approach with the colour of skin.

3rd, Chen, female, 40 years old, there was the flat wart one of about 0.5cm diameters right face brows lower section, and in September, 2016 comes here It is medical, paste coating flat wart surface of the present invention is given, is put on the skin within 20 minutes or so after removing, further anti-inflammatory processing, wart takes off within 2 weeks or so Fall, illing skin is deeper, gradually recovers within 1 month or so to approach with the colour of skin.

5th, poplar, intractable thorn monkey, diameter 0.3-0.5cm, comes here and goes to a doctor in May, 2016, gives patch patch of the present invention On flat wart surface, processing in 30 minutes or so terminates, further anti-inflammatory processing, repetitive administration 2-3 times after incrustation comes off, 2 Or so moon can remove, and skin recovers preferable.

Claims

A kind of 1. Chinese medicine composition for repairing face skin care, it is characterised in that：The Chinese medicine composition by following parts by weight medicine system Into：Black false hellebore 15-25 parts, sweet wormwood 15-25 parts, straw 15-25 parts, buckwheat bar 15-25 parts, eggplant bar 15-25 parts, Chinese waxgourd stem 20-30 parts, Mulberry bavin 20-30 parts, purslane 20-30 parts, green salt 40-50 parts, lime 40-50 parts, folium artemisiae argyi 40-50 parts.
2. the Chinese medicine composition as claimed in claim 1 for repairing face skin care, it is characterised in that：The Chinese medicine composition is by weight It is calculated as：20 parts of black false hellebore, 20 parts of sweet wormwood, 20 parts of straw, 20 parts of buckwheat bar, 20 parts of eggplant bar, 25 parts of Chinese waxgourd stem, 25 parts of mulberry bavin, purslane 25 parts, 45 parts of green salt, 45 parts of lime, 45 parts of folium artemisiae argyi.
3. the Chinese medicine composition as claimed in claim 1 or 2 for repairing face skin care, it is characterised in that：The preparation method of composition is such as Under：

1) formula ratio Chinese medicine is taken, in addition to lime, green salt, charing process after remaining 10 taste is dried, then grinds sieving for standby；

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and add 75% alcohol, are placed 10-30 days after being sufficiently mixed, after fermentation Produce Chinese medicine composition.
4. the Chinese medicine composition as claimed in claim 3 for repairing face skin care, it is characterised in that：Charing process is in the step 1) Using the method carbonized in direct burning carbonate or high temperature service；It was ground into the fine powder of 60-100 mesh sieves.
5. the Chinese medicine composition as claimed in claim 3 for repairing face skin care, it is characterised in that：Lime, green salt in the step 2) It is ground into the particle that particle diameter is less than 0.5mm.
6. the Chinese medicine composition as claimed in claim 3 for repairing face skin care, it is characterised in that：Fermentation is placed in the step 3) is Under conditions of closed, 20-30 DEG C of environment temperature places 10-15 days, environment temperature 10-20 DEG C of placement 15-20 days, environment temperature 0-10 DEG C is placed 20-30 days.
7. the Chinese medicine composition as claimed in claim 1 or 2 for repairing face skin care, it is characterised in that：The Chinese medicine composition and medicine Acceptable auxiliary material, is made external preparation on.
8. the Chinese medicine composition as claimed in claim 7 for repairing face skin care, it is characterised in that：The preparation is paste, lotion, patch Agent.
9. the Chinese medicine composition as claimed in claim 8 for repairing face skin care, it is characterised in that：The preparation method of paste is as follows：

1) formula ratio Chinese medicine is taken, in addition to lime, green salt, charing process after remaining 10 taste is dried, then grinds sieving for standby；

2) lime, green salt crush respectively, stand-by；

3) fine powder by step 1) and 2) and particle mix, and add 75% alcohol, are placed 10-30 days after being sufficiently mixed, after fermentation Produce Chinese medicine composition；

4) aforesaid fermentation thing is added into appropriate amounts of gelatin, glycerine, vaseline or camellia oil, is modulated into cream, produces.

Wherein, charing process is using the method carbonized in direct burning carbonate or high temperature service in the step 1)；It is ground into Cross the fine powder of 60-100 mesh sieves.

Lime, green salt are ground into the particle that particle diameter is less than 0.5mm in the step 2).

It is under conditions of closed that fermentation is placed in the step 3), and 20-30 DEG C of environment temperature places 10-15 days, environment temperature 10-20 DEG C is placed 15-20 days, placement 20-30 days of 0-10 DEG C of environment temperature.
10. the Chinese medicine composition and its preparation of claim 1 or 2 or 8 dispel melanotic nevus knurl, senile plaque expelling, thorn monkey, flat in preparation Application in flat wart, yellow face wart medicine.