CN101926876A - Traditional Chinese medicine ointment for treating psoriasis, stubborn dermatitis and pruritus, and preparation method thereof - Google Patents
Traditional Chinese medicine ointment for treating psoriasis, stubborn dermatitis and pruritus, and preparation method thereof Download PDFInfo
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- CN101926876A CN101926876A CN2010102688681A CN201010268868A CN101926876A CN 101926876 A CN101926876 A CN 101926876A CN 2010102688681 A CN2010102688681 A CN 2010102688681A CN 201010268868 A CN201010268868 A CN 201010268868A CN 101926876 A CN101926876 A CN 101926876A
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Abstract
The application relates to a traditional Chinese medicine ointment for treating psoriasis, stubborn dermatitis and pruritus, and a preparation method thereof. The conventional medicaments for treating psoriasis, stubborn dermatitis and pruritus most belong to the immunosuppressant with harmful influences on the normal immunologic functions and cause low resistance of patients and serious influences on the treatment after long-term use. The ointment comprises the following components in part by weight: 40 to 60 parts of pseudolarix, 20 to 40 parts of dock root, 20 to 40 parts of lightyellow sophora root, 20 to 40 parts of garden balsam stem, 40 to 60 parts of zanthoxylum pipertum DC, 40 to 60 parts of clove, 90 to 110 parts of soapberry, 40 to 60 parts of pomegranate rind, 20 to 40 parts of large head atractylodes rhizome, 20 to 40 parts of Chinese honeylocust fruit, and 1,000 parts of ointment matrix. The ointment is used for treating psoriasis, stubborn dermatitis and pruritus.
Description
Technical field:
The present invention relates to a kind of Chinese medicine ointment for the treatment of psoriasis, various stubborn dermatitis, pruritus and preparation method thereof.
Background technology:
Psoriasis, various stubborn dermatitis, pruritus are very common chronic dermatosis.Doctor trained in Western medicine it be unclear that the psoriasic cause of disease, does not also have a kind of medicine at present and can reach radical cure.Many patients when treatment psoriasis, various stubborn dermatitis, pruritus owing to do not follow the medication requirement, not only do not improve disease symptoms, missed best treatment opportunity on the contrary, treatment time is long, the medicine of treatment belongs to the immunosuppressant class mostly at present, and normal immunologic function is had harmful effect, if the blindness long-term prescription, can make the lower for the resistance of patient, have a strong impact on treatment.
Present medicine and method mainly contain following several
1. steroid hormone: corticosteroid hormone ointment (frost) external has 20 years history.Potent steroid hormone ointment (frost) external cleaning, instant effect, but drug withdrawal easily recurs, the life-time service side effect increases, so a lot of doctor's tendency need not, or only short-term, be interrupted and use.The intensity of medicine has very big difference, from the mild to the super strong type.The intensity of hormone has determined how long the skin in which zone can not have side effects with using in medication.Excessively use the common side effect in back to comprise thinning of skin, stretch cicatrix and the Drug resistance of this hormone.
2. suppress DNA class medicine: its side effect is little, but the normal skin around the psoriatic lesion that can stimulate or burn.
3. phototherapy (UVB): under doctor's specialized guidance, treat psoriatic lesion general hair style or local obstinate type with Type B ultraviolet (UVB).Can unite use with the external medication method.There is very little risk to use UVB in a short time.The risk of life-time service UVB is the same with being exposed to the sun in the sun: skin carcinoma and skin aging.Short-term use the side effect of PUVA common stomach discomfort arranged, skin rubefaction is itched.Life-time service can increase the trouble skin splash, skin senilism, the chance of cataract etc.Repeatedly investigation to the patient that accepts PUVA treatment for a long time shows, can cause suffering from the risk of some skin carcinoma after life-time service PUVA therapy.
Above-mentioned treatment medicine and method mainly are to eliminate symptom, avoid further deterioration, can't effect a radical cure.Side effect is bigger, uses and wants prudent.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine ointment for the treatment of psoriasis, various stubborn dermatitis, pruritus and preparation method thereof, evident in efficacy, and the difficult recurrence in recovery from illness back, the patient no longer needs the life-time service medicine to keep, and does not develop immunity to drugs.
Above-mentioned purpose realizes by following technical scheme:
The Chinese medicine ointment of treatment psoriasis, various stubborn dermatitis, pruritus, its composition comprises: Cortex Pseudolaricis, Radix Rumicis, Radix Sophorae Flavescentis, Herba speranskiae tuberculatae, Fructus Zanthoxyli, Flos Caryophylli, wood are suffered from son, Pericarpium Granati, the Rhizoma Atractylodis Macrocephalae, Fructus Gleditsia, ointment substrate, and its parts by weight are: 1000 parts of Cortex Pseudolaricis 40-60 parts, Radix Rumicis 20-40 part, Radix Sophorae Flavescentis 20-40 part, Herba speranskiae tuberculatae 20-40 part, Fructus Zanthoxyli 40-60 part, Flos Caryophylli 40-60 part, the sub-90-110 part of wood trouble, Pericarpium Granati 40-60 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Fructus Gleditsia 20-40 part ointment substrate.
The Chinese medicine ointment of described treatment psoriasis, various stubborn dermatitis, pruritus, described ointment substrate comprises stearic acid, potassium hydroxide, glycerol, ethyl hydroxybenzoate, distilled water, and its parts by weight are: 150 parts of stearic acid, 7 parts of potassium hydroxide, 50 parts of glycerol, 1 part of ethyl hydroxybenzoate, 792 parts of distilled water.
The preparation method of the Chinese medicine ointment of above-mentioned treatment psoriasis, various stubborn dermatitis, pruritus, this method is:
(1) substrate preparation: get 150 parts of heating of stearic acid by weight and dissolve, be incubated 70-80 ℃; Other gets 7 parts of potassium hydroxide, 50 parts of glycerol, 792 parts of 1 part of adding distil waters of ethyl hydroxybenzoate, and heating makes dissolving, is incubated 70-80 ℃, and the stearic acid liquid that makes is slowly added in the liquid of back, and the limit edged constantly is stirred to condensation with same direction;
(2) Cortex Pseudolaricis 40-60 part, Radix Rumicis 20-40 part, Radix Sophorae Flavescentis 20-40 part, Herba speranskiae tuberculatae 20-40 part, Fructus Zanthoxyli 40-60 part, Flos Caryophylli 40-60 part, the sub-90-110 part of wood trouble, Pericarpium Granati 40-60 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Fructus Gleditsia 20-40 part are crushed to 200 orders, mixing, also constantly be ground to evenly in the substrate that adding step (1) makes, packing promptly.
Beneficial effect:
1. psoriasis, various stubborn dermatitis, pruritus initial stage are caused by wind, wet, pathogenic heat retardance skin, so that QI-blood circulation loses freely, with the passing of time consume impairment of YIN blood, seek deficiency of YIN, and wind syndrome due to blood-deficiency, dryness-transformation are due to the failure of skin and muscle to be nourished.Then to dispel the wind, heat clearing away, dampness, to nourish blood, the poison that purifies the blood from the source thoroughly changes heat in blood, blood stasis, the dry phenomenon of blood, and opens a mao key, qi and blood circulation promotion, the poison that gets rid of illness, treating both the principal and secondary aspects of a disease method of the present invention.By famous and precious natural Chinese medicine, compatibility forms drug utilization Du Genggao, more remarkable treatment effect meticulously.
2. this product is a kind of external-applied ointment, and effect is good during the treatment, and is evident in efficacy, and the difficult recurrence in recovery from illness back, and the patient no longer needs the life-time service medicine to keep, and does not develop immunity to drugs.
3. this product does not contain additives such as any hormone, Fructus Psoraleae, advantage without any side effects.
4. medicine of the present invention has significant curative effect through the evidence safety non-toxic to the treatment vitiligo, and its toxicology and pharmacodynamic experiment data are as follows:
Skin irritation test: the stimulus intensity to rabbit skin belongs to nonirritant.The skin allergic reaction experiment: sensitization rate 0%, sensitization intensity belong to extremely slightly degree.
Long term toxicity test: respectively with 0.8g/kg, apply medicinal lotion or ointment to rat skin, every day three times, continuous 60 days, result of the test showed that general state, behavioral activity and the diet situation and the matched group that are tried rat do not have significant difference; Hematology, liver function, renal function and organ coefficient and matched group more all do not have significant difference, show that life-time service medicine of the present invention is safe.
5. it is as follows to carry out patient's clinical trial: 150 routine psoriasiss, various stubborn dermatitis, pruritus patient patient offer the degree of minister dermatosis section hospital according to the state of an illness in the Harbin that the applicant founds, and the patient of this medicine of clinical practice is divided into 3 groups, every group 50 people.
1,50 routine psoriasiss, various stubborn dermatitis, pruritus patient are ill in 1 year, and the affected part is at 7cm
2In.Offer minister dermatosis section hospital clinical practice 2 months in Harbin, therapeutic effect sees Table 1:
This medicine of table 1 is to psoriasis, various stubborn dermatitis, pruritus patient's therapeutic effect:
50 routine psoriasiss, various stubborn dermatitis, pruritus patient are ill in 5 years, and the affected part is at 10cm
2In.Offer minister dermatosis section hospital clinical practice 6 months in Harbin, therapeutic effect sees Table 2:
This medicine of table 2 is to psoriasis, various stubborn dermatitis, pruritus patient's therapeutic effect:
50 routine psoriasiss, various stubborn dermatitis, pruritus patient are ill in 10 years, and the affected part is at 50cm
2In.Offer minister dermatosis section hospital clinical practice 8 months in Harbin, therapeutic effect is as follows:
This medicine of table 3 is to psoriasis, various stubborn dermatitis, pruritus patient's therapeutic effect
Patient's clinical manifestation: its symptom is normal or filbert flat little scrofula from the beginning of color of the leather, and the surface is little bright, and of a specified duration increasing gradually merged in flakes, pachyderma, and sulci of skin is deepened, and is dry coarse, is the lichen sample and becomes, and desquamation is very itched, and pain is not known in scratching of having.Also there are the coin of being shape, map shape in sick place, return shape, vesicle is arranged, crowfoot cracks etc. individually.Different parts, symptom differs, and outbreak increases the weight of year by year repeatedly.
The standard of medical effect evaluation: effectively: 1, just sloughed the sclerderm dead bark of body surface, the skin wounds of chapping also begins rapid healing, and pruritus alleviates, and squama reduces.2, the focus area dwindles, and is linked to be large stretch of tinea piece originally and has become isolated one by one red point, and squama further reduces, and the sufferings sense is most of to disappear.3, gloss appears in skin, the basic recovery normally, and scratchiness disappears substantially.4, sufferings sense complete obiteration, cutaneous pigmentation disappears, and recover normally fully at the skin lesion position.
Statistical result: effective 95%, recovery from illness 80%, invalid 5%.
The result shows: medicine of the present invention can obviously be treated psoriasis, various stubborn dermatitis, pruritus.
The specific embodiment:
Embodiment 1:
The Chinese medicine ointment of treatment psoriasis, various stubborn dermatitis, pruritus, its composition comprises: Cortex Pseudolaricis, Radix Rumicis, Radix Sophorae Flavescentis, Herba speranskiae tuberculatae, Fructus Zanthoxyli, Flos Caryophylli, wood are suffered from son, Pericarpium Granati, the Rhizoma Atractylodis Macrocephalae, Fructus Gleditsia, ointment substrate, and its parts by weight are: 50 parts of Cortex Pseudolaricis, 30 parts of Radix Rumiciss, 30 parts of Radix Sophorae Flavescentiss, 30 parts of Herba speranskiae tuberculataes, 50 parts of Fructus Zanthoxylis, 50 parts of Flos Caryophyllis, wood are suffered from 100 parts of sons, 50 parts of Pericarpium Granatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Fructus Gleditsia, 1000 parts of ointment substrate.
The Chinese medicine ointment of described treatment psoriasis, various stubborn dermatitis, pruritus, described ointment substrate comprises stearic acid, potassium hydroxide, glycerol, ethyl hydroxybenzoate, distilled water, and its parts by weight are: 150 parts of stearic acid, 7 parts of potassium hydroxide, 50 parts of glycerol, 1 part of ethyl hydroxybenzoate, 792 parts of distilled water.
The preparation method of the Chinese medicine ointment of above-mentioned treatment psoriasis, various stubborn dermatitis, pruritus, this method is:
(1) substrate preparation: get 150 parts of heating of stearic acid by weight and dissolve, be incubated 70-80 ℃; Other gets 7 parts of potassium hydroxide, 50 parts of glycerol, 792 parts of 1 part of adding distil waters of ethyl hydroxybenzoate, and heating makes dissolving, is incubated 70-80 ℃, and the stearic acid liquid that makes is slowly added in the liquid of back, and the limit edged constantly is stirred to condensation with same direction;
(2) 50 parts of Cortex Pseudolaricis, 30 parts of Radix Rumiciss, 30 parts of Radix Sophorae Flavescentiss, 30 parts of Herba speranskiae tuberculataes, 50 parts of Fructus Zanthoxylis, 50 parts of Flos Caryophyllis, 100 parts of wood trouble, 50 parts of Pericarpium Granatis, 30 parts of the Rhizoma Atractylodis Macrocephalaes, Fructus Gleditsia are crushed to 200 orders for 30 parts, mixing, also constantly be ground to evenly in the substrate that adding step (1) makes, packing promptly.
Using method: ointment is applied to the affected part, rotates more than wiping 5-10 minute every day 2-3 time gently.
Claims (3)
1. Chinese medicine ointment for the treatment of psoriasis, various stubborn dermatitis, pruritus, its composition comprises: Cortex Pseudolaricis, Radix Rumicis, Radix Sophorae Flavescentis, Herba speranskiae tuberculatae, Fructus Zanthoxyli, Flos Caryophylli, wood are suffered from son, Pericarpium Granati, the Rhizoma Atractylodis Macrocephalae, Fructus Gleditsia, ointment substrate, and it is characterized in that: its parts by weight are: 1000 parts of Cortex Pseudolaricis 40-60 parts, Radix Rumicis 20-40 part, Radix Sophorae Flavescentis 20-40 part, Herba speranskiae tuberculatae 20-40 part, Fructus Zanthoxyli 40-60 part, Flos Caryophylli 40-60 part, the sub-90-110 part of wood trouble, Pericarpium Granati 40-60 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Fructus Gleditsia 20-40 part, ointment substrate.
2. the Chinese medicine ointment of treatment psoriasis according to claim 1, various stubborn dermatitis, pruritus, it is characterized in that: described ointment substrate comprises stearic acid, potassium hydroxide, glycerol, ethyl hydroxybenzoate, distilled water, and its parts by weight are: 150 parts of stearic acid, 7 parts of potassium hydroxide, 50 parts of glycerol, 1 part of ethyl hydroxybenzoate, 792 parts of distilled water.
3. preparation method for the treatment of the Chinese medicine ointment of psoriasis, various stubborn dermatitis, pruritus, it is characterized in that: this method is:
(1) substrate preparation: get 150 parts of heating of stearic acid by weight and dissolve, be incubated 70-80 ℃; Other gets 7 parts of potassium hydroxide, 50 parts of glycerol, 792 parts of 1 part of adding distil waters of ethyl hydroxybenzoate, and heating makes dissolving, is incubated 70-80 ℃, and the stearic acid liquid that makes is slowly added in the liquid of back, and the limit edged constantly is stirred to condensation with same direction;
(2) Cortex Pseudolaricis 40-60 part, Radix Rumicis 20-40 part, Radix Sophorae Flavescentis 20-40 part, Herba speranskiae tuberculatae 20-40 part, Fructus Zanthoxyli 40-60 part, Flos Caryophylli 40-60 part, the sub-90-110 part of wood trouble, Pericarpium Granati 40-60 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Fructus Gleditsia 20-40 part are crushed to 200 orders, mixing, also constantly be ground to evenly in the substrate that adding step (1) makes, packing promptly.
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| CN201010268868.1A CN101926876B (en) | 2010-09-01 | 2010-09-01 | Traditional Chinese medicine ointment for treating psoriasis, stubborn dermatitis and pruritus, and preparation method thereof |
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| CN201010268868.1A CN101926876B (en) | 2010-09-01 | 2010-09-01 | Traditional Chinese medicine ointment for treating psoriasis, stubborn dermatitis and pruritus, and preparation method thereof |
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| CN101926876A true CN101926876A (en) | 2010-12-29 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830385A (en) * | 2014-02-25 | 2014-06-04 | 苗相臣 | Psoriasis paste |
| CN105943598A (en) * | 2016-06-04 | 2016-09-21 | 汪锦川 | Externally applied medicine for treating ear pruritus and processing technology thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736423A (en) * | 2005-07-29 | 2006-02-22 | 罗敏 | Method for preparing externally applied medicine for feet tinea |
| CN101979029A (en) * | 2010-10-06 | 2011-02-23 | 阚景祥 | Chinese medicinal narcotic |
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- 2010-09-01 CN CN201010268868.1A patent/CN101926876B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1736423A (en) * | 2005-07-29 | 2006-02-22 | 罗敏 | Method for preparing externally applied medicine for feet tinea |
| CN101979029A (en) * | 2010-10-06 | 2011-02-23 | 阚景祥 | Chinese medicinal narcotic |
Non-Patent Citations (2)
| Title |
|---|
| 党小利: "中草药抗真菌的研究进展", 《现代医药卫生》 * |
| 包佐义等: "中药洗剂浸泡治疗足癣感染63例", 《皮肤病与性病》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830385A (en) * | 2014-02-25 | 2014-06-04 | 苗相臣 | Psoriasis paste |
| CN103830385B (en) * | 2014-02-25 | 2016-05-04 | 苗相臣 | Psoriasis paster |
| CN105943598A (en) * | 2016-06-04 | 2016-09-21 | 汪锦川 | Externally applied medicine for treating ear pruritus and processing technology thereof |
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| CN101926876B (en) | 2014-03-05 |
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Granted publication date: 20140305 Termination date: 20190901 |