CN107714677A - A kind of liquid Wound surface protection film and preparation method thereof - Google Patents
A kind of liquid Wound surface protection film and preparation method thereof Download PDFInfo
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- CN107714677A CN107714677A CN201711106254.1A CN201711106254A CN107714677A CN 107714677 A CN107714677 A CN 107714677A CN 201711106254 A CN201711106254 A CN 201711106254A CN 107714677 A CN107714677 A CN 107714677A
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- ethanol
- protection film
- surface protection
- chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Abstract
The present invention relates to a kind of liquid Wound surface protection film, according to mass fraction meter, including 1.5 2 parts of polyvinyl alcohol, 20 25 parts of ethanol, 1 1.5 parts of chitosan, 75 80 parts of purified water；Pass through polyvinyl alcohol, purified water is made into 1.5% 2% aqueous solution, chitosan is added in 95% (V/V) ethanol, 45min is mixed to having dissolved, poly-vinyl alcohol solution, chitosan ethanol solution are finally mixed into 45min to uniform, sampling sampling observation, it is filling, spiral cover, finally packed.The liquid Wound surface protection film can quickly form diaphragm, have good protective effect to the surface of a wound, and the healing to wound has good facilitation.
Description
Technical field
The invention belongs to medicine field, and in particular to a kind of liquid Wound surface protection film and preparation method thereof.
Background technology
Early 20th century, Johnson Co. took the lead in releasing adhesive bandage.Even to this day, adhesive bandage still plays powerful work
With.Modern society, living standard gradually rise, the image consciousness enhancing of people；Rhythm of life is accelerated, and simple and direct be applicable seems particularly
It is important.This causes the appearance of liquid preparation liquid Wound surface protection film to turn into inevitable.
Polyvinyl alcohol is unique high molecular weight water soluble polymer in nature, and its good hydrophilic property, abundance, price are low
It is honest and clean.There is made of polyvinyl alcohol the water-soluble substance of excellent water absorption and swelling, biological degradability and stability, cartilage, cornea,
Had broad application prospects in the transplanting replacement of the tissues such as nucleus pulposus, skin and reconstruction.Polyvinyl alcohol water solution is as burning
Hindering the repair materials of the surface of a wound has and the surface of a wound can be kept to moisten, and is advantageous to the growth and reparation of epithelial cell.As for pharmaceutic adjuvant,
Polyvinyl alcohol is good filmogen, is applied to as film forming agent in liquid adhesive bandage.
Wound surface protection film advantage, which is that, rapid draing and to form ventilative, waterproof and flexible diaphragm.In addition, wound
Surface protective film can be very good to avoid the irregular shape of mouth due to wound and cause adhesive plaster adhesive bandage to be difficult to post, paste the shortcomings that firm.
Liquid Wound surface protection film on the market involves great expense at present, while effect is bad, promotes epithelial cell growth and repaiies
Complex velocity is slow.
The content of the invention
The present invention proposes a kind of liquid Wound surface protection film, and the liquid Wound surface protection film can quickly form diaphragm, to wound
Face has good protective effect, and the healing to wound has good facilitation.
For above-mentioned prior art, the present invention is intended to provide a kind of liquid Wound surface protection film, including polyvinyl alcohol 1.5-2
Part, ethanol 20-25 parts, chitosan 1-1.5 parts, purified water 75-80 parts.
Further, described liquid Wound surface protection film, according to mass fraction meter, including 2 parts of polyvinyl alcohol, ethanol 25
Part, 1 part of chitosan, 76 parts of purified water.
Further, described ethanol is the ethanol that concentration of volume percent is 95%.
The invention provides a kind of above-mentioned preparation method of liquid Wound surface protection film, comprise the following steps：
（1）Polyvinyl alcohol is made into the 1.5%-2% aqueous solution with purified water, it is standby；
（2）Chitosan is added in 95% (V/V) ethanol, it is complete to dissolving to mix 45min；
（3）By poly-vinyl alcohol solution, chitosan ethanol solution, 45min is mixed to uniform；
（4）Sampling sampling observation, filling, spiral cover, packaging.
Beneficial effects of the present invention：
The present invention discloses a kind of liquid Wound surface protection film, and the liquid Wound surface protection film can quickly form diaphragm, to the surface of a wound
With good protective effect, the healing to wound has good facilitation.
The liquid Wound surface protection film of the present invention is applied to the rapid draing of surface of a wound energy and forms ventilative, waterproof, softness and have bullet
Property diaphragm, while be easy to peel off, to body surface caused by abrading, burn, scald the superficial surface of a wound and other traumas cause it is small
The surface of a wound has hemostasis, protects the effect of wound, while has the function that to promote healing to being chapped from the cold, and the diaphragm permeability is good, can put
The invasion of foreign matter and bacterium is put, effectively prevents wound infection, additionally it is possible to alleviates the pain gargalesthesia of wound healing phase.
Embodiment
Embodiment 1
A kind of liquid Wound surface protection film, according to mass fraction meter, including：It is 2 parts of polyvinyl alcohol, 25 parts of ethanol, 1 part of chitosan, pure
Change 76 parts of water, wherein the ethanol is the ethanol that concentration of volume percent is 95%.
Its preparation method is to comprise the following steps：
（1）Polyvinyl alcohol is made into purified water to 2% aqueous solution, it is standby；
（2）Chitosan is added in 95% (V/V) ethanol, it is complete to dissolving to mix 45min；
（3）By poly-vinyl alcohol solution, chitosan ethanol solution, 45min is mixed to uniform；
（4）Sampling sampling observation, filling, spiral cover, packaging.
Embodiment 2
A kind of liquid Wound surface protection film, according to mass fraction meter, including：1.5 parts of polyvinyl alcohol, 20 parts of ethanol, chitosan 1.5
Part, 80 parts of purified water, wherein the ethanol is the ethanol that concentration of volume percent is 95%.
Its preparation method is to comprise the following steps：
（1）Polyvinyl alcohol is made into purified water to 1.5% aqueous solution, it is standby；
（2）Chitosan is added in 95% (V/V) ethanol, it is complete to dissolving to mix 45min；
（3）By poly-vinyl alcohol solution, chitosan ethanol solution, 45min is mixed to uniform；
（4）Sampling sampling observation, filling, spiral cover, packaging.
Embodiment 3
A kind of liquid Wound surface protection film, according to mass fraction meter, including：1.8 parts of polyvinyl alcohol, 22 parts of ethanol, chitosan 1.2
Part, 75 parts of purified water, wherein the ethanol is the ethanol that concentration of volume percent is 95%.
Its preparation method is the same as embodiment 1.
Embodiment 4
Case is illustrated：
Liao, man, 36 years old, the test tube in experimentation accidentally by breakage scratched finger, there is blood outflow.It is sprayed on using this product
At the surface of a wound, just layer protecting film is formed in the surface of a wound rapidly within 3 minutes or so, the surface of a wound, which is bled, to be stopped.After sprinkling daily 1-3 times, 3 days,
The surface of a wound is given birth to close to healing, noninductive hair dyeing.
The technical scheme provided above the embodiment of the present invention is described in detail, specific case used herein
The principle and embodiment of the embodiment of the present invention are set forth, the explanation of above example is only applicable to help and understands this
The principle of inventive embodiments, protection scope of the present invention not limited to this.Those skilled in the art are on the basis of the present invention
The equivalent substitute made or conversion, within protection scope of the present invention.Protection scope of the present invention using claims as
It is accurate.
Claims (4)
1. a kind of liquid Wound surface protection film, it is characterised in that according to mass fraction meter, including polyvinyl alcohol 1.5-2 parts, ethanol
20-25 parts, chitosan 1-1.5 parts, purified water 75-80 parts.
2. liquid Wound surface protection film according to claim 1, it is characterised in that according to mass fraction meter, including polyethylene
2 parts of alcohol, 25 parts of ethanol, 1 part of chitosan, 76 parts of purified water.
3. liquid Wound surface protection film according to claim 1 or 2, it is characterised in that described ethanol is percent by volume
Concentration is 95% ethanol.
4. the preparation method of the liquid Wound surface protection film described in claim 1, it is characterised in that comprise the following steps：
（1）Polyvinyl alcohol is made into the 1.5%-2% aqueous solution with purified water, it is standby；
（2）Chitosan is added in 95% (V/V) ethanol, it is complete to dissolving to mix 45min；
（3）By poly-vinyl alcohol solution, chitosan ethanol solution, 45min is mixed to uniform；
（4）Sampling sampling observation, filling, spiral cover, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106254.1A CN107714677A (en) | 2017-11-10 | 2017-11-10 | A kind of liquid Wound surface protection film and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106254.1A CN107714677A (en) | 2017-11-10 | 2017-11-10 | A kind of liquid Wound surface protection film and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107714677A true CN107714677A (en) | 2018-02-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711106254.1A Pending CN107714677A (en) | 2017-11-10 | 2017-11-10 | A kind of liquid Wound surface protection film and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN107714677A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245652A (en) * | 2020-10-16 | 2021-01-22 | 合肥贝壳派创新科技有限公司 | Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof |
| CN114225099A (en) * | 2021-12-22 | 2022-03-25 | 青岛农业大学 | Traditional Chinese medicine compound polysaccharide-silver nano liquid band-aid and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931198A (en) * | 2006-09-25 | 2007-03-21 | 昆明创邦医疗器械有限公司 | Wound protecting and treating smearing prepn |
| CN103463669A (en) * | 2013-09-16 | 2013-12-25 | 重庆海默尼生物技术有限公司 | Liquid wound dressing and preparation method thereof |
-
2017
- 2017-11-10 CN CN201711106254.1A patent/CN107714677A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931198A (en) * | 2006-09-25 | 2007-03-21 | 昆明创邦医疗器械有限公司 | Wound protecting and treating smearing prepn |
| CN103463669A (en) * | 2013-09-16 | 2013-12-25 | 重庆海默尼生物技术有限公司 | Liquid wound dressing and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112245652A (en) * | 2020-10-16 | 2021-01-22 | 合肥贝壳派创新科技有限公司 | Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof |
| CN114225099A (en) * | 2021-12-22 | 2022-03-25 | 青岛农业大学 | Traditional Chinese medicine compound polysaccharide-silver nano liquid band-aid and preparation method thereof |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180223 |
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