CN104257639B - A kind of liniment for Wound treating and preparation method thereof - Google Patents
A kind of liniment for Wound treating and preparation method thereof Download PDFInfo
- Publication number
- CN104257639B CN104257639B CN201410544706.4A CN201410544706A CN104257639B CN 104257639 B CN104257639 B CN 104257639B CN 201410544706 A CN201410544706 A CN 201410544706A CN 104257639 B CN104257639 B CN 104257639B
- Authority
- CN
- China
- Prior art keywords
- liniment
- water
- recipe quantity
- preparation
- prescription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940040145 liniment Drugs 0.000 title claims abstract description 49
- 239000000865 liniment Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920001661 Chitosan Polymers 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims description 13
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 11
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 11
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 3
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 2
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 23
- 239000002904 solvent Substances 0.000 abstract description 7
- 230000001408 fungistatic effect Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 206010072170 Skin wound Diseases 0.000 abstract description 4
- 239000004014 plasticizer Substances 0.000 abstract description 4
- 241000894006 Bacteria Species 0.000 description 26
- 206010052428 Wound Diseases 0.000 description 21
- 238000012360 testing method Methods 0.000 description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000000853 adhesive Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 8
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- 229960001631 carbomer Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000006916 nutrient agar Substances 0.000 description 4
- 238000007747 plating Methods 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 239000011260 aqueous acid Substances 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007766 curtain coating Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of liniment for Wound treating and preparation method thereof, comprise chitosan, filmogen, plasticizer and solvent, wherein said plasticizer is glycerol, and the amount of glycerol is the 2-15% of product gross weight.It is better that liniment of the present invention has fungistatic effect, and use more convenient, the use not by skin wound shape and size limits, and does not affect normal limb activity, the advantages such as water resistance is better.
Description
Technical field
The present invention relates to a kind of liniment for Wound treating and preparation method thereof, this liniment is applicable to the treatment of skin surface either shallow wound, surgical wound surface, empyrosis wound surface and ulcer wound surface, belongs to medical art.
Background technology
Skin is the maximum organ of human body, is also one of most important organ of human body, mainly carries protection health, perspire, feels cold and hot and the function of pressure; Skin covers whole body, and it to make in body various tissue and organ from the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism.Meanwhile, skin trauma is also a kind of common surgery frequently-occurring disease, and the factors such as the burn in daily life, scald, knife injury, infection, medicine and immunoreation all may make skin histology sustain damage.The wound surface that skin trauma causes easily causes bleeding on the one hand, oozing of blood, and the pain that wound surface and extraneous contact cause can have a strong impact on work and the life of patient, even leaves cicatrix impact attractive in appearance; On the other hand, if dealt with improperly, can cause infection, bring various complication, severe patient is threat to life even.Therefore, to effective nursing of skin wound be field of medicaments research important content.
20 th America Johson & Johnson take the lead in releasing adhesive bandage, and through the development of last 100 years, the adhesive bandage of various forms specification is applied.Adhesive bandage can hemostasis by compression, protection wound surface, prevention infection, volume is little, use the advantages such as simple and easy to carry, uses extensively so far.But adhesive bandage has fixed dimension, to the wound surface poor selectivity of different area and character, and external adhesive plaster poor air permeability, the normocrinic steam of body local and perspiration can not penetrate this layer of adhesive plaster, can produce action of soaking to local skin; In addition, adhesive bandage water resistance is poor, and affects the orthobiosis of patient after using.
Liniment is a kind of by medicine dissolution or in being scattered in containing filmogen solvent, is coated with film forming liquid preparation for external application after putting affected part on the skin.It is compared with adhesive bandage class external preparation, there is preparation process thereof simpler, without the need to back lining materials, do not need special machine equipment, use more convenient, be not subject to the restriction of skin wound shape and size, do not affect normal limb activity, water resistance is better, reduces the anaphylactic reaction because using binding agent to cause, water white transparency, does not affect advantages such as using position attractive in appearance.Therefore, liniment causes the world of medicine to pay attention to day by day.Such as patent application CN-201310421208.6 discloses a kind of liquid Wound dressing (i.e. liniment), following raw material primarily of parts by weight obtains: medical high polymer filmogen 100-180 part, chitosan 0-20 powder, PEG400 10-25 part, glycerol 10-28 part, mixed solvent 800-1000 part of etoh solvent or ethanol and deionized water; Chitosan 2% acetic acid solution dissolves; Wherein macromolecule filming material is the mixture of the wherein a kind of and carbomer in a kind of or polyvinyl alcohol in polyvinyl alcohol and polyvinyl butyral resin and polyvinyl butyral resin.
Within 2005, the version Pharmacopoeia of the People's Republic of China embodies strengthening by attention degree of liniment to recording of liniment, and the innovation research developing into liniment of polymer material science and percutaneous technique provides opportunity, except filming performance, the important content of person's concern that the pharmacodynamic feature of bio-compatible, biodegradation, filmogen self and the interaction between formulation materials and prescription drug also become pharmacy work.
Summary of the invention
The present invention aims to provide a kind of liniment and preparation method thereof, and it is applicable to the auxiliary treatment of skin surface either shallow wound, otch, surgical wound surface, burn wound, ulcer wound surface, has and promotes wound healing, antibacterial, the effect that alleviates cicatrization.
In existing liniment, general glycerol content is lower, mainly plays the effect of moisturizing, lubrication, increase product viscosity and adhesion.The present inventor is surprisingly found out that, after increasing substantially glycerol content, under physical property (film property and adhesion etc.) the impregnable prerequisite of liniment, can improve the fungistatic effect of product significantly.
Liniment for Wound treating of the present invention, comprise chitosan, filmogen, plasticizer and solvent, wherein said plasticizer is glycerol, the amount of glycerol is the 2-15% of product gross weight, the amount being preferably glycerol is the 5-12% of product gross weight, it is an option that the amount of glycerol is 10% of product gross weight.
Liniment for Wound treating of the present invention, formula is (mass percent):
Be preferably, the liniment for Wound treating of the present invention, formula is (mass percent):
It is an option that: the liniment for Wound treating of the present invention, formula is (mass percent):
Water-soluble chitosan 2.0%
Polyvinyl alcohol 2,488 5.0%
Glycerol 10.0%
Water
82.97％
Ethylparaben sodium
0.03％。
Of the present invention in the liniment of Wound treating, described chitosan is chitosan or modified water-soluble chitosan, described filmogen is polyvinyl alcohol, sodium alginate, polyvinyl formal-acetal, polyvinyl butyral resin, carbomer, sodium carboxymethyl cellulose and hydroxypropyl methylcellulose, described solvent is water, prioritizing selection distilled water or deionized water, if needed, also can use containing aqueous acid, as contained 2% second aqueous acid; Described antiseptic is parabens, sodium benzoate or benzalkonium bromide.Chitosan can not be water-soluble, can only be dissolved in dilute acid soln, such as 2% acetic acid solution, and water-soluble chitosan can be completely soluble in water, avoids employing acetic acid solution, decreases the zest of wound.
The preparation method of the liniment for Wound treating of the present invention, comprises the steps:
A, by the appropriate dissolution with solvents of the antiseptic of recipe quantity, obtained solution one;
B, the filmogen of recipe quantity and chitosan are placed in appropriate vessel, add the solvent of residue recipe quantity wherein, limit edged stirring and evenly mixing, the glycerol of recipe quantity is added after swelling 30 minutes, intensification limit is stirred to 80 DEG C gradually, until all dissolve, and obtained solution two;
C, to be cooled to after room temperature until solution two and to add solution one, be uniformly mixed;
D, the mixture of step C gained is at room temperature placed about 24h, reduce pressure degassed to fill after bubble-free.
Be preferably, the preparation method of the liniment for Wound treating of the present invention, comprises the steps:
A, the antiseptic suitable quantity of water of recipe quantity to be dissolved, obtained solution one;
B, the polyvinyl alcohol 2488 of recipe quantity and water-soluble chitosan are placed in appropriate vessel, add the water of residue recipe quantity wherein, limit edged stirring and evenly mixing, the glycerol of recipe quantity is added after swelling 30 minutes, intensification limit is stirred to 80 DEG C gradually, until all dissolve, and obtained solution two;
C, to be cooled to after room temperature until solution two and to add solution one, be uniformly mixed;
D, the mixture of step C gained is at room temperature placed about 24h, reduce pressure degassed to fill after bubble-free.
Compared with existing product, it is better that liniment of the present invention has fungistatic effect, uses more convenient, use not by skin wound shape and size limits, and does not affect normal limb activity, reduces the anaphylactic reaction because using binding agent to cause, water white transparency, does not affect advantages such as using position attractive in appearance.
In the present invention, all amounts, part are mass percent unit, and all raw materials all can be buied from market.
By the following specific examples further illustrate the invention, but embodiment only for illustration of, can not limit scope of the present invention, any amendment made technical scheme of the present invention is all within the scope of the invention.
Detailed description of the invention
Embodiment 1: the preparation of liniment
(1) prescription composition:
The prescription composition of table 1 liniment
In prescription 1-5, polyvinyl alcohol 2488 can use sodium alginate, polyvinyl formal-acetal, polyvinyl butyral resin, carbomer, sodium carboxymethyl cellulose and hydroxypropyl methylcellulose to replace.Coloring agent or the correctives of reasonable addition is also included in ethylparaben sodium.
(2) preparation method of the liniment of prescription one to prescription five:
1, the antiseptic suitable quantity of water of recipe quantity is dissolved, obtained solution one;
2, the polyvinyl alcohol 2488 of recipe quantity and water-soluble chitosan are placed in appropriate vessel, add the distilled water of residue recipe quantity wherein, limit edged stirring and evenly mixing, the glycerol of recipe quantity is added after swelling 30 minutes, intensification limit is stirred to 80 DEG C gradually, until all dissolve, and obtained solution two;
3, be cooled to after room temperature until solution two and add solution one, be uniformly mixed;
4, the mixture of step 3 gained is at room temperature placed about 24h, reduce pressure degassed to fill after bubble-free, obtain liniment of the present invention.
Embodiment 2: the bacteriostatic experiment of liniment
(1) strain: staphylococcus aureus CMCC (B) 26003] the 4th generation; (note: Guangdong Province's Culture Collection provides)
(2) bacterium solution preparation: get above-mentioned staphylococcus aureus, making every 1ml containing bacterium number with 0.9% aseptic sodium chloride solution is the bacteria suspension of 50 ~ 100cfu.
(3) test sample test group: the above-mentioned bacteria suspension (50 ~ 100cfu/ml) of the liniment and 1ml of getting the preparation of a certain amount of embodiment 1 prescription one to prescription five injects plate, pours into nutrient agar immediately.Often criticize the parallel preparation of test sample 2 plates, cultivate 3 days at 30-35 DEG C, then measure its bacterium number by Plating.
Viable bacteria group: get above-mentioned bacteria suspension 1ml (50 ~ 100cfu/ml) and inject plate, pour into nutrient agar immediately.Parallel preparation 2 plates, cultivate 3 days, measure its bacterium number by Plating at 30-35 DEG C.
(4) bacteriostasis rate calculates
Bacterium number × 100 of suppression ratio (%)=(the bacterium number of the bacterium number-test group of viable bacteria group)/viable bacteria group
The antibacterial of each test group the results are shown in Table 2.
The antibacterial result of table 2
According to the data of table 2, the liniment of prescription one to prescription five all can suppress the growth of staphylococcus aureus effectively.But compared with the liniment of the prescription one of same amount, there were significant differences (p<0.05) for the bacteriostasis rate of the liniment of prescription three and prescription five; The liniment of prescription four has the difference (p<0.01) of highly significant.As can be seen here, the fungistatic effect of consumption on liniment of glycerol has obvious impact, and the glycerol of 5%-12% can increase the fungistatic effect of liniment significantly, and especially the glycerol of 10% can increase the fungistatic effect of liniment very significantly.
Embodiment 3: the preparation of liniment
(1) prescription composition:
The prescription composition of table 3 liniment
In prescription 6-10, polyvinyl alcohol 2488 can use sodium alginate, polyvinyl formal-acetal, polyvinyl butyral resin, carbomer, sodium carboxymethyl cellulose and hydroxypropyl methylcellulose to replace.Coloring agent or the correctives of reasonable addition is also included in ethylparaben sodium.Water can be deionized water or distilled water.
(2) preparation method of the liniment of prescription six to prescription ten:
1, the antiseptic suitable quantity of water of recipe quantity is dissolved, obtained solution one.
2, the polyvinyl alcohol 2488 of recipe quantity and water-soluble chitosan are placed in appropriate vessel, add the water of residue recipe quantity wherein, limit edged stirring and evenly mixing, the glycerol of recipe quantity is added after swelling 30 minutes, intensification limit is stirred to 80 DEG C gradually, until all dissolve, and obtained solution two.
3, be cooled to after room temperature until solution two and add solution one, be uniformly mixed.
4, the mixture of step 3 gained is at room temperature placed about 24h, reduce pressure degassed to fill after bubble-free, obtain liniment of the present invention.
(3) the film property test of prescription six to prescription ten:
Temperature 20 ~ 25 DEG C, under relative humidity 45 ~ 65% condition, liniment is sprayed at curtain coating on dry plate glass and paves evenly, after natural drying, timing forms transparent or semitransparent film.
Film forming in prescription six 10min, film forming in prescription seven 30min, prescription eight and film forming in prescription nine 7min, film forming in prescription ten 5min.Show consumption when polyvinyl alcohol in prescription >=5% time, filming performance is excellent.
(4) bacteriostatic test of prescription six to prescription ten:
(1) strain: staphylococcus aureus CMCC (B) 26003] the 4th generation; (note: Guangdong Province's Culture Collection provides)
(2) bacterium solution preparation: get above-mentioned staphylococcus aureus, making every 1ml containing bacterium number with 0.9% aseptic sodium chloride solution is the bacteria suspension of 50 ~ 100cfu.
(3) test sample test group: the above-mentioned bacteria suspension (50 ~ 100cfu/ml) of the liniment and 1ml of getting the preparation of a certain amount of prescription six to prescription ten injects plate, pours into nutrient agar immediately.Often criticize the parallel preparation of test sample 2 plates, cultivate 3 days at 30-35 DEG C, then measure its bacterium number by Plating.
Viable bacteria group: get above-mentioned bacteria suspension 1ml (50 ~ 100cfu/ml) and inject plate, pour into nutrient agar immediately.Parallel preparation 2 plates, cultivate 3 days, measure its bacterium number by Plating at 30-35 DEG C.
(4) bacteriostasis rate calculates
Bacterium number × 100 of suppression ratio (%)=(the bacterium number of the bacterium number-test group of viable bacteria group)/viable bacteria group
The antibacterial of each test group the results are shown in Table 4.
The antibacterial result of table 4
According to the data of table 4, the liniment of prescription six to prescription ten all can suppress the growth of staphylococcus aureus effectively.
Claims (4)
1., for a liniment for Wound treating, it is characterized in that the one-tenth of the formulation consists mass percent of liniment is grouped into:
2. the liniment for Wound treating according to claim 1, is characterized in that described antiseptic is parabens, sodium benzoate or benzalkonium bromide.
3. the liniment for Wound treating according to claim 1 and 2, is characterized in that the one-tenth of the formulation consists mass percent of liniment is grouped into:
4., according to the preparation method of the liniment for Wound treating one of claim 1-3 Suo Shu, it is characterized in that comprising the steps:
A, the antiseptic suitable quantity of water of recipe quantity to be dissolved, obtained solution one;
B, the polyvinyl alcohol 2488 of recipe quantity and water-soluble chitosan are placed in appropriate vessel, add the water of residue recipe quantity wherein, limit edged stirring and evenly mixing, the glycerol of recipe quantity is added after swelling 30 minutes, intensification limit is stirred to 80 DEG C gradually, until all dissolve, and obtained solution two;
C, to be cooled to after room temperature until solution two and to add solution one, be uniformly mixed;
D, the mixture of step C gained is at room temperature placed about 24h, reduce pressure degassed to fill after bubble-free.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410544706.4A CN104257639B (en) | 2014-10-15 | 2014-10-15 | A kind of liniment for Wound treating and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410544706.4A CN104257639B (en) | 2014-10-15 | 2014-10-15 | A kind of liniment for Wound treating and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104257639A CN104257639A (en) | 2015-01-07 |
| CN104257639B true CN104257639B (en) | 2015-09-09 |
Family
ID=52149301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410544706.4A Expired - Fee Related CN104257639B (en) | 2014-10-15 | 2014-10-15 | A kind of liniment for Wound treating and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104257639B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311684A (en) * | 2015-11-13 | 2016-02-10 | 邢月军 | Surgical film for stopping bleeding and relieving pain |
| CN105288697A (en) * | 2015-11-13 | 2016-02-03 | 邢月军 | Medical film for surgery |
| CN105363065A (en) * | 2015-11-13 | 2016-03-02 | 邢月军 | Antibacterial and anti-inflammatory membrane |
| CN105381499A (en) * | 2015-11-19 | 2016-03-09 | 耿文真 | Medical membrane with effect of promoting wound healing and preparation process thereof |
| CN105327384A (en) * | 2015-11-19 | 2016-02-17 | 耿文真 | Absorbable medical biological membrane dressing and preparation method thereof |
| CN105434404B (en) * | 2015-12-18 | 2018-07-17 | 江苏海智生物医药有限公司 | A kind of plastics for protecting wound surface |
| CN105561381B (en) * | 2016-01-07 | 2018-09-07 | 青岛大学 | A kind of preparation method of marine organisms nano-antibacterial gelation liquid adhesive bandage |
| CN105497976B (en) * | 2016-01-07 | 2018-07-10 | 青岛大学 | A kind of trauma wound is applied with the preparation method with functional ointment |
| CN105797202B (en) * | 2016-03-23 | 2020-04-24 | 广州瑞辉生物科技股份有限公司 | Liquid band-aid and preparation method thereof |
| CN105816908B (en) * | 2016-04-29 | 2017-04-12 | 哈尔滨乾佰纳生物药业有限公司 | Waterproof liquid wound protection film and preparation method thereof |
| CN105963281A (en) * | 2016-07-05 | 2016-09-28 | 青岛明药堂医疗股份有限公司 | Chitin scar-restraint gel coating as well as preparation method and application thereof |
| CN106075560A (en) * | 2016-07-26 | 2016-11-09 | 上海第二工业大学 | A kind of preparation method of polymeric liquid adhesive bandage |
| CN106178096A (en) * | 2016-08-30 | 2016-12-07 | 张阳 | A kind of wound fluid film and preparation method thereof |
| CN107670099A (en) * | 2017-11-28 | 2018-02-09 | 苏州汇涵医用科技发展有限公司 | A kind of liquid dressing and preparation method thereof |
| CN107951959B (en) * | 2017-12-22 | 2021-01-26 | 海南医学院 | Callicarpa nudiflora film coating agent and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579559A (en) * | 2004-05-14 | 2005-02-16 | 中国科学院长春应用化学研究所 | Dressing material containing medicine chitoholosida and its preparation method |
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN103751833A (en) * | 2014-01-28 | 2014-04-30 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
-
2014
- 2014-10-15 CN CN201410544706.4A patent/CN104257639B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579559A (en) * | 2004-05-14 | 2005-02-16 | 中国科学院长春应用化学研究所 | Dressing material containing medicine chitoholosida and its preparation method |
| CN103083713A (en) * | 2012-12-10 | 2013-05-08 | 江苏华亿细胞组织工程有限公司 | Sterile polymerized covering dressing for wound surface |
| CN103751833A (en) * | 2014-01-28 | 2014-04-30 | 北京百利康生化有限公司 | Medical antibacterial wound dressing and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 涂膜剂研究概述;金玲等;《中国实验方剂学杂志》;20120430;第18卷(第8期);第277-280页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104257639A (en) | 2015-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104257639B (en) | A kind of liniment for Wound treating and preparation method thereof | |
| CN107412847A (en) | A kind of Wound dressing of liquid form and preparation method thereof | |
| CN102058900B (en) | Waterproof liquid bandage for wound surface protection and preparation method thereof | |
| CN107970488A (en) | A kind of chitin quarternary ammonium salt aquagel antiseptic dressing and preparation method thereof | |
| CN105816911A (en) | Repairing gel containing growth factors and preparation method of repairing gel | |
| CN105012993A (en) | Medical and antibacterial cationic biogel dressing and preparation method thereof | |
| CN103494668A (en) | Medical hydrogel moisturizing eye care mask and preparation method thereof | |
| CN110859989B (en) | Liquid band-aid and preparation method thereof | |
| CN104740141B (en) | A kind of antimicrobial spray and preparation method thereof | |
| CN110876814A (en) | Liquid band-aid rich in antibacterial peptide and preparation method thereof | |
| CN110201218A (en) | Liquid adhesive bandage and preparation method thereof | |
| CN104095876B (en) | A kind of stable medical protection flushing liquor and preparation method thereof | |
| CN109568650A (en) | A kind of chitosan quaternary ammonium salt antiseptic dressing and preparation method thereof | |
| CN105616296B (en) | A kind of poplar Chinese holly flower itching-relieve skin-care mud | |
| CN105126158B (en) | Polysaccharide fiber element hemostasis isolation antibacterial repairs glue and preparation method thereof | |
| CN107595819B (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN101904986B (en) | Compound aloetic bacteriostatic traditional Chinese medicine film and preparation method thereof | |
| CN105412977A (en) | Chitosan wound dressing | |
| CN103040729A (en) | Chitosan gel for removing acne scars as well as preparation method and medical application thereof | |
| CN105560166A (en) | Gynecological external antibacterial gel with silver ions and method for preparing gynecological external antibacterial gel | |
| RU2649790C1 (en) | Antiseptic composition containing unithiol and dimethylsulfoxide, application of such a composition and method of wound treatment with the use of it | |
| CN102526121B (en) | Wound repair composition and preparation method and application thereof | |
| CN106474137B (en) | A kind of film for treating oral ulcer containing chlorophyll and preparation method thereof | |
| CN105664224B (en) | A kind of compound alginic acid dressing of low molecular weight carboxymethyl chitosan and preparation method thereof | |
| CN108042654A (en) | A kind of preparation process of the anti-inflammatory degerming gel containing honey |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170419 Address after: 651701 Songming Yang Lin Industrial Development Zone, Kunming, China Road, No. 5, Patentee after: KUNMING YUANRUI PHARMACEUTICAL Co.,Ltd. Address before: 523000 Guangdong province Dongguan City Songshan Lake Industrial Lu He Xi Si Lu in the 8 Building 406 room Patentee before: GUANGDONG PUSHI PHARMACEUTICAL TECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190613 Address after: 523000 Tea Health Products Factory Building, No. 7 Changyuan Road, Songshan Lake High-tech Industrial Development Zone, Dongguan City, Guangdong Province, 3rd Floor Patentee after: Dongguan Gejiu Health Technology Co.,Ltd. Address before: 651701 No. 5 Huashi Road, Yanglin Industrial Development Zone, Songming County, Kunming City, Yunnan Province Patentee before: KUNMING YUANRUI PHARMACEUTICAL Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200424 Address after: 651701 Huashi Road, Yanglin Industrial Development Zone, Kunming, Yunnan Patentee after: KUNMING YUANRUI PHARMACEUTICAL Co.,Ltd. Address before: 523000 Tea Health Products Factory Building, No. 7 Changyuan Road, Songshan Lake High-tech Industrial Development Zone, Dongguan City, Guangdong Province, 3rd Floor Patentee before: Dongguan Gejiu Health Technology Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150909 |