CN105434404B - A kind of plastics for protecting wound surface - Google Patents
A kind of plastics for protecting wound surface Download PDFInfo
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- CN105434404B CN105434404B CN201510949178.5A CN201510949178A CN105434404B CN 105434404 B CN105434404 B CN 105434404B CN 201510949178 A CN201510949178 A CN 201510949178A CN 105434404 B CN105434404 B CN 105434404B
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- plastics
- wound surface
- wound
- protecting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of plastics for protecting wound surface, belong to biological medicine, medical mechanical domain science and technology field.A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 5% 25%, moisturizer 0.1% 5%, plasticizer 0.1% 5%, ethyl alcohol 50% 85%, surfactant 0.01% 2%, purified water 1% 10%.The plastics that the present invention prepares can quickly form one layer of formation soft texture after being applied to affected part in the surface of a wound; it is not easily to fall off; nontoxic non-stimulated skin sparing film; the film has good water preventing ability, gas permeability, the property covered; and external foreign matter and microorganism invasion and infection to wound are prevented, has the function of protecting the surface of a wound, promote wound healing.
Description
Technical field
The invention belongs to biological medicine, medical mechanical domain science and technology fields, and in particular to a kind of for protecting wound surface
Plastics.
Background technology
It often will appear the small surface of a wound of the body surfaces such as burn, scald, scratch, scuffing in people's daily life.The surface of a wound can locally be made
At different degrees of tissue necrosis and rupture of blood vessel bleeding, there is inflammatory reaction, causes local redness.Therefore, protecting wound surface, rush
Healing has become an important subject in wound repair field.
Currently, in the traditional processing method of the small surface of a wound of body surface, for burn, scald wound, ointments preparation is used mostly,
But ointments preparation is easy pollution clothes, it is possible to create the secondary pollution of the surface of a wound；For abrading, scratching, then mostly using wound
Mouth patch, gauze, but bandage or gauze are easy to form secondary insult in dressing, may also cause wound sense after meeting water
Patient's action is wrapped up or influenced to dye in difficult local.
Acrylic resin be by acrylic acid and methacrylic acid or their ester, as methyl esters, butyl ester, dimethylamino ethyl ester,
The monomers such as chlorination dimethylamine base ester a kind of high-molecular compound made of being copolymerized with certain proportion.The polymer is nontoxic, non-stimulated
Property, be not absorbed by the body, and polymers function multi-size has been widely used in sustained release pellet, sustained-release matrix tablets, solid point
In the novel pharmaceutical formulations such as granular media, microballoon and micro-capsule, oral colon-specific drug delivery system and transdermal drug delivery system, which has peace
Entirely, stablize, inertia and it is non-stimulated the advantages that, the present invention in as filmogen be applied to protecting wound surface in, the surface of a wound
Protection can quickly form waterproof, ventilative, soft texture, not easily to fall off, nontoxic non-stimulated skin sparing film after being applied to affected part.
Invention content
It is an object of the invention to overcome the shortcomings of in the traditional processing method of the small surface of a wound of existing body surface, provide it is a kind of for
Protecting wound surface plays good water proofing property, gas permeability and prevents microorganism infection and promote the plastics of healing.
To achieve the above object, the present invention provides the following technical solutions：
A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 5%-25% is protected
Humectant 0.1%-5%, plasticizer 0.1%-5%, ethyl alcohol 50%-85%, surfactant 0.01%-2%, purified water 1%-10%.
Further technical solution, plastics include the following components'mass percentage：Acrylic resin 8%-21%, moisturizing
Agent 0.5%-4%, plasticizer 0.5%-4%, ethyl alcohol 65%-80%, surfactant 0.05%-2%, purified water 2%-8%.
Further technical solution, the moisturizer are glycerine, propylene glycol, butanediol, polyethylene glycol, sorbierite, sweet tea
One kind in dish alkali, urea or two kinds；
The plasticizer is glycerine, turpentine oil, propylene glycol, sorbierite, diethyl phthalate, phthalic acid two
One kind in butyl ester, glyceryl triacetate, triethyl citrate or two kinds；
The surfactant is one in poly yamanashi esters surfactant, fatty acid sorbitan class surfactant
Kind；
The poly yamanashi esters surfactant is polyoxyethylene sorbitan monoleate or polysorbate 60；The aliphatic acid sorb
Smooth class surfactant is span 20 or span 40.
Further technical solution, the acrylic resin are powdered or graininess.
Further technical solution, the acrylic resin are butyl methacrylate, dimethylaminoethyl
Ethyl ester and methylmethacrylate copolymer or methacrylic acid and ethyl acrylate copolymer；
The molar ratio of the butyl methacrylate, Dimethylaminoethyl Methacrylate and methyl methacrylate is
1:2:1；
The molar ratio of the methacrylic acid and ethyl acrylate is 1:1.
Further technical solution, the acrylic resin are ethyl acrylate, methyl methacrylate and methyl-prop
The copolymer of olefin(e) acid quaternary ammonium group trim.
Further technical solution, the methacrylic acid quaternary ammonium group trim are methacrylic acid trimethyl ammonium chloride bases
Ethyl ester.
Further technical solution, the ethyl acrylate, methyl methacrylate and methacrylic acid chlorination front three
The molar ratio of aminoethyl is 1：（1.8-2.2）：（0.1-0.4）.
Further technical solution, the ethyl acrylate, methyl methacrylate and methacrylic acid chlorination front three
The molar ratio of aminoethyl is 1:2:0.1,1:2.17:0.17,1:2:0.2 or 1:2:0.33.
The preparation method of further technical solution, the plastics includes the following steps：Ethyl alcohol and purified water are taken, is mixed
After closing uniformly, acrylic resin is slowly added in ethanol water, stirring and dissolving, is heated to 25 DEG C -80 DEG C, wait being completely dissolved
After sequentially add moisturizer, plasticizer, surfactant, stir and evenly mix, it is filling after irradiation sterilization.
Advantageous effect
Compared with prior art, the present invention has following remarkable advantage：
1, the plastics that the present invention prepares can quickly form one layer of formation soft texture after being applied to affected part in the surface of a wound, be not easy
It falls off, nontoxic non-stimulated skin sparing film, the film has good water preventing ability, gas permeability, the property covered, and prevents extraneous different
The invasion and infection of object and microorganism to wound have the function of protecting the surface of a wound, promote wound healing.The product is applicable not only to
The small surface of a wound of body surfaces such as burn, scald, scratch, scuffing, frostbite, chap, can be used for caused superficial wound, diabetes after lift face
Or the exanthemv etc. of chemotherapy patients.Only this product need to be uniformly applied to when use through processed surface wound, it is rapid dry
Formed after dry block water, breathe freely, comfortable protective film, wound healing caudacoria can voluntarily fall off, safe to use, conveniently, can be according to wound
The size and location in face is arbitrarily smeared.
2, acrylic resin is pharmaceutical grade macromolecule filming material in the present invention, the material have safe and stable, inertia and
The advantages that non-stimulated.
3, the moisturizer in the present invention improves the comfort of skin after smearing film forming；Plasticizer has well with acrylic resin
Compatibility, the flexibility of film can be improved；Ethyl alcohol has sterilization, disinfection, and has volatility, can fast filming；Surface-active
Agent has solubilization, can improve this product stability.
4, the preparation process of the plastics in the present invention is simple, of low cost, does not need special installation, adds in preparation process
Heat can accelerate its solution rate.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail.
Embodiment 1
A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 8%, glycerine
0.5%, triethyl citrate 0.5%, ethyl alcohol 85%, polyoxyethylene sorbitan monoleate 0.1%, purified water 5.9%.The acrylic resin is powder
Last shape or graininess.The acrylic resin is ethyl acrylate, methyl methacrylate and methacrylic acid chlorination three
The molar ratio of the copolymer of methylamino ethyl ester, copolymer is 1:2:0.2.The ethyl alcohol and purified water of aforementioned proportion are taken, is uniformly mixed
Afterwards, acrylic resin is slowly added in ethanol water, stirring and dissolving, heats 60 DEG C, its solution rate can be accelerated, waited for completely
Glycerine, the triethyl citrate of the ratio are sequentially added after dissolving, polyoxyethylene sorbitan monoleate stirs and evenly mixs, filling rear irradiation sterilization
.
Embodiment 2
A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 20%, glycerine
1%, propylene glycol 3%, turpentine oil 2%, diethyl phthalate 2%, ethyl alcohol 65%, polysorbate 60 2%, purified water 5%.Described
Acrylic resin is butyl methacrylate, Dimethylaminoethyl Methacrylate and methylmethacrylate copolymer, copolymerization
The molar ratio of object is 1:2:1.Take the ethyl alcohol and purified water of aforementioned proportion, after mixing, acrylic resin is slowly added to second
In alcohol solution, stirring and dissolving is heated to 80 DEG C, can accelerate its solution rate, sequentially adds the ratio until completely dissolved
Glycerine, propylene glycol, turpentine oil, diethyl phthalate, polysorbate 60 stirs and evenly mixs, it is filling after irradiation sterilization.
Embodiment 3
A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 12.5%, fourth
Glycol 1%, glyceryl triacetate 1%, triethyl citrate 1%, ethyl alcohol 75%, span 20 1%, purified water 8.5%.The propylene
Acid resin is methacrylic acid and ethyl acrylate copolymer, and the molar ratio of copolymer is 1:1.Take the ethyl alcohol of aforementioned proportion and pure
Change water acrylic resin is slowly added in ethanol water after mixing, stirring and dissolving is heated to 30 DEG C, can accelerate it
Solution rate sequentially adds butanediol, the glyceryl triacetate of the ratio, triethyl citrate, sapn until completely dissolved
20, it stirs and evenly mixs, filling rear irradiation sterilization.
Embodiment 4
A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 24%, poly- second
Glycol 0.2%, dibutyl phthalate 0.2%, ethyl alcohol 73%, span 40 1.5%, purified water 1.1%.The acrylic resin
It is the copolymer of ethyl acrylate, methyl methacrylate and methacrylic acid trimethyl ammonium chloride base ethyl ester, mole of copolymer
Than being 1:2:0.1.The ethyl alcohol and purified water of aforementioned proportion are taken, after mixing, it is water-soluble that acrylic resin is slowly added to ethyl alcohol
In liquid, stirring and dissolving is heated to 40 DEG C, can accelerate its solution rate, sequentially adds the poly- second of the ratio until completely dissolved
Glycol, dibutyl phthalate, span 40 stir and evenly mix, filling rear irradiation sterilization.
Embodiment 5
A kind of plastics for protecting wound surface include the following components'mass percentage：Acrylic resin 12%, sorb
Alcohol 1%, glycine betaine 2%, turpentine oil 3%, ethyl alcohol 70%, polyoxyethylene sorbitan monoleate 2%, purified water 10%.The acrylic resin is propylene
The copolymer of acetoacetic ester, methyl methacrylate and methacrylic acid trimethyl ammonium chloride base ethyl ester, the molar ratio of copolymer is 1:
2:0.2.It takes the ethyl alcohol and purified water of aforementioned proportion that acrylic resin is slowly added in ethanol water after mixing, stirs
Dissolving is mixed, is heated to 50 DEG C, its solution rate can be accelerated, sequentially adds sorbierite, the beet of the ratio until completely dissolved
Alkali, turpentine oil, polyoxyethylene sorbitan monoleate stir and evenly mix, filling rear irradiation sterilization.
Following tests is made for the plastics of the present invention：
1, the efficiency assay for the plastics of protecting wound surface
There are 10 patients voluntarily to participate in the efficiency assay of plastics of the present invention.Patient smears in skin affected part daily to implement
The plastics that in example 1-5 prepared by any formula are primary, and 7 days as a course for the treatment of, observation patient wound's hemostasis, the inhibition of inflammation and wound
The effect of mouth healing.Test result shows plastics energy effective protection wound of the present invention and promotes wound healing, total effective percentage
It is 100%, 7 days complete healing rates are 80-90%.
2, it is tested for the film forming of the plastics of protecting wound surface
By the plastics of preparation on glass plate, the liquid thickness being coated on glass plate is controlled using spreader
60 μm, glass plate is put into 37 DEG C of baking ovens immediately after film, is taken out after a period of time, film on glass plate is touched
Part, it is most of tack-free（Or gloves）It is judged to form a film.As starting point at the time of film formation time is to be put into baking oven, with from baking oven
It is terminal meter at the time of middle taking-up.Test result shows that film formation time is no more than 60s.
3, the permeability test for the plastics of protecting wound surface
The film that thickness is about 200 μm is made in the plastics of preparation, is tried by method specified in YY/T 0471.2-2004
It tests.Test result shows that the plastics that in embodiment 1-5 prepared by any formula all have good gas permeability.
4, it is tested for the water preventing ability of the plastics of protecting wound surface
The film that thickness is about 200 μm is made in the plastics of preparation, takes the hydrostatic column of an open at both ends, by sample
It is placed on one end of container and covers a piece of filter paper on the upper surface of which, then put sealing ring clamping.Sample and filter paper will be put
Downward, open one end upward, water is injected into container and the height of water column is made to be 30 mm, maintains 300 s of the hydrostatic pressing for one end,
It checks whether to have on filter paper and be seeped water by sample, sample does not seep water, and experiment passes through.Test result shows any in embodiment 1-5
Plastics prepared by formula have good water preventing ability.
5, it is tested for the comfort of the plastics of protecting wound surface
The film for being about 200 μm at thickness by the plastics of preparation is tried by method specified in YY/T 0471.4-2004
It tests.Test result shows that the plastics extensibility that in embodiment 1-5 prepared by any formula is not more than 14 Ncm-1, permanent deformation
Amount is not more than 5%, has good comfort.
6, it is tested for the biological safety of the plastics of protecting wound surface
The plastics for taking preparation carry out cytotoxicity, skin irritatin, skin according to by method specified in GB/T 16886
Sensitization test (STT), test result show that the plastics that in embodiment 1-5 prepared by any formula have good biological safety.
7, it is tested for the resistance bacterium property of the plastics of protecting wound surface
The plastics 10mL for taking preparation is poured into the sterilized petri dishes of a diameter of 90 mm and is formed a film（Membrance casting condition is at room temperature
18h）, removed with sterile working after film forming, by method test as defined in YY/T 0471.5-2004 3.1, test result
Show that the plastics that in embodiment 1-5 prepared by any formula have good resistance bacterium property.
Claims (9)
1. a kind of plastics for protecting wound surface, which is characterized in that include the following components'mass percentage：Acrylic resin
5%-25%, 0 .1%-5% of moisturizer, plasticizer 0 .1%-5%, ethyl alcohol 50%-85%, 0 .01%-2% of surfactant, purified water
1%-10%；
The acrylic resin is that butyl methacrylate, Dimethylaminoethyl Methacrylate and methyl methacrylate are total
Polymers or methacrylic acid and ethyl acrylate copolymer；The butyl methacrylate, dimethylaminoethyl
The molar ratio of ethyl ester and methyl methacrylate is 1:2:1；
The molar ratio of the methacrylic acid and ethyl acrylate is 1:1.
2. a kind of plastics for protecting wound surface according to claim 1, which is characterized in that plastics include following matter
Measure the component of percentage：Acrylic resin 8%-21%, 0 .5%-4% of moisturizer, plasticizer 0 .5%-4%, ethyl alcohol 65%-80%, table
Face activating agent 0 .05%-2%, purified water 2%-8%.
3. a kind of plastics for protecting wound surface according to claim 1 or 2, which is characterized in that the moisturizer
It is one kind in glycerine, propylene glycol, butanediol, polyethylene glycol, sorbierite, glycine betaine, urea or two kinds；
The plasticizer is glycerine, turpentine oil, propylene glycol, sorbierite, diethyl phthalate, two fourth of phthalic acid
One kind in ester, glyceryl triacetate, triethyl citrate or two kinds；
The surfactant is one kind in poly yamanashi esters surfactant, fatty acid sorbitan class surfactant；
The poly yamanashi esters surfactant is polyoxyethylene sorbitan monoleate or polysorbate 60；
The fatty acid sorbitan class surfactant is span 20 or span 40.
4. a kind of plastics for protecting wound surface according to claim 1 or 2, which is characterized in that the acrylic acid
Resin is powdered or graininess.
5. a kind of plastics for protecting wound surface according to claim 4, which is characterized in that the acrylic resin
It is the copolymer of ethyl acrylate, methyl methacrylate and methacrylic acid quaternary ammonium group trim.
6. a kind of plastics for protecting wound surface according to claim 5, which is characterized in that the methacrylic acid
Quaternary ammonium group trim is methacrylic acid trimethyl ammonium chloride base ethyl ester.
7. a kind of plastics for protecting wound surface according to claim 6, which is characterized in that the acrylic acid second
The molar ratio of ester, methyl methacrylate and methacrylic acid trimethyl ammonium chloride base ethyl ester is 1：（1 .8-2 .2）：（0 .1-0
.4）.
8. a kind of plastics for protecting wound surface according to claim 6, which is characterized in that the acrylic acid second
The molar ratio of ester, methyl methacrylate and methacrylic acid trimethyl ammonium chloride base ethyl ester is 1:2:0 .1,1:2 .17:0
.17,1:2:0 .2 or 1:2:0 .33.
9. a kind of plastics for protecting wound surface according to claim 1 or 2, which is characterized in that the plastics
Preparation method include the following steps：Ethyl alcohol and purified water are taken, after mixing, it is water-soluble that acrylic resin is slowly added to ethyl alcohol
In liquid, stirring and dissolving is heated to 25 DEG C -80 DEG C, sequentially adds moisturizer, plasticizer, surfactant until completely dissolved, stirs
Mix mixing, filling rear irradiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510949178.5A CN105434404B (en) | 2015-12-18 | 2015-12-18 | A kind of plastics for protecting wound surface |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510949178.5A CN105434404B (en) | 2015-12-18 | 2015-12-18 | A kind of plastics for protecting wound surface |
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| CN105434404A CN105434404A (en) | 2016-03-30 |
| CN105434404B true CN105434404B (en) | 2018-07-17 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3478234A4 (en) * | 2016-06-29 | 2020-02-26 | IVIEW Therapeutics, Inc. | Novel rapid-deposition thin-film forming compositions as effective wound care treatment |
| CN112076342A (en) * | 2019-06-12 | 2020-12-15 | 陕西佰傲再生医学有限公司 | Skin wound protection composition and preparation method thereof |
| CN111084902B (en) * | 2019-12-17 | 2022-05-20 | 成都博创必成生物技术有限公司 | Liquid dressing and preparation method thereof |
| CN115025293A (en) * | 2022-06-09 | 2022-09-09 | 振德医疗用品股份有限公司 | Smearing type operation film and preparation method thereof |
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Address after: Building B2, No. 9, Kechuang Avenue, Jiangbei new district, Nanjing, Jiangsu Province, 210032 Patentee after: JIANGSU HIGH-WIT BIOTECHNOLOGY Co.,Ltd. Address before: 210032, Jiangsu province Nanjing hi tech Development Zone, Spark Road 10, ding industry, 100 Thai biological building C block 301 room Patentee before: JIANGSU HIGH-WIT BIOTECHNOLOGY Co.,Ltd. |