CN1579373A - Transparent disappearing external administration carrier - Google Patents
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- CN1579373A CN1579373A CN 200410037730 CN200410037730A CN1579373A CN 1579373 A CN1579373 A CN 1579373A CN 200410037730 CN200410037730 CN 200410037730 CN 200410037730 A CN200410037730 A CN 200410037730A CN 1579373 A CN1579373 A CN 1579373A
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Abstract
The present invention provides a transparent and adelomorphic film coating agent, as a medicinal preparation for external applications, used for treating skin diseases and beauty treatment health care, especially a gel film coating agent which contains effective medicine concentration therein and is characterized by the activity components of the effective medicine concentration, film forming materials and biological adhesive agents contained therein. Said film coating agent also comprise preferably a gel elasticizer which will dry itself, after being coated to skins for 2-5 minutes, to form homogeneous, colorlessful and transparent adelomorphic films and begin to release medicines. Said adelomorphic film coating agent possesses favorable skin adhesivity, crock resistance, breathing property and isolation properties, is capable of prolonging pharmaceutical curative effects, and avoids frictions between sicken skin and clothing to avoid cross-infections.
Description
Technical field of the present invention
The present invention relates to a kind of transparent, cryptomorphic external medicine preparation---liniment, have good adhesiveness, wear-resisting wiping and hidden property, particularly a kind of transparent, stealthy gel liniment that comprises effective active component of this topical administration carrier, be used for the treatment of dermatosis, be used for aspects such as health and beauty.
Background technology of the present invention
External medicine preparation can be widely used in fields such as treating skin disease, wound, pain relieving, health and beauty.
Skin infection is common by the caused infectious disease of pathogenic microorganism in people's daily life, has certain infectiousness, as tinea, herpes or the like.Dermopathic healing is avoided self cross infection except reasonable use medicine, prolong drug action time is the key factor that can not be ignored.
Non-infectious dermatosis and skin trauma in Drug therapy, also need ill skin is carried out special protection, as psoriasis and wound, should avoid skin and medicated clothing between friction, prevent the deterioration of the state of an illness and increase patient's misery.
Externally-used pain-relieving or health care plaster, owing to some the viscose composition that contains causes user allergy, or some breakage, young tender position can't administration.
In above-mentioned treatment and using, all need a kind of safe, non-stimulated, can play with outside good isolation effect, reduce the new formulation of drug loss, prolong drug curative effect, this new formulation also needs to have certain practicality simultaneously, and good adhesiveness, transparent hidden property are promptly arranged.All there are certain shortcoming in external medicine preparation such as preparations such as powder agent, spray, solution, lotion, unguentum, gel, membrane and patch commonly used at present, for example medicine is to the inefficiency of lesions position transmission, can not prevent patient's self cross infection, when patient's normal activity, cause drug loss owing to rubbing, the misery that perhaps adds the heavy patient because of friction is easy to pollute medicated clothing, bedding of patient etc.; And the patch with backing layer may produce allergy even ulcer phenomenon owing to the breathability difference; Wiping not attractive in appearance when membrane is used for exposure portion, not wear-resisting, and these problems of being brought by dosage form also may cause patient's compliance to reduce, thus further reduce therapeutic effect.Therefore, need a kind of topical formulations easy to clean to obtain more effective treatment.
Membrane or the liniment made with macromolecular material appearred in recent years, for example US 5,888,494 A disclose a kind of liniment that contains opioid with filmogen preparation commonly used, but be inconvenient to carry, and this liniment only comprises filmogen commonly used, does not solve film caducous problem and stealthy problem when being subjected to rubbing that liniment forms.The not relevant report that can overcome external preparation above-mentioned defective, that contain required active component in the prior art, so need a kind of novel, wear-resisting wiping, do not have above-mentioned defective, do not comprise the selected formulations of active ingredients of above-mentioned patent, so that a more effective topical administration system can be provided.
Description of the invention
The objective of the invention is to provide a kind of evident in efficacy, easy to use, market prospect is wide and do not have external preparation---the stealthy liniment of above-mentioned defective.
Though in the prior art relevant for the report of making liniment with macromolecular material, but the present invention finds surprisingly, film former and a kind of bioadhesive polymer are mixed in certain proportion, can obtain a kind of liniment with unexpected effect, this liniment is a gel, in that be coated on the skin can be dry voluntarily after 2-5 minute, form uniform, water white stealthy film and begin to discharge medicine.Its formed this thin film has good cohesive, contractility and wearability, be not in the situation that will deliberately be removed, and it can continue closely to stick on and reaches on the skin about 24 hours.In addition, this liniment can be used for the skin affected part of Any shape and size; This thin film also has good permeability, has the good compatibility with skin, and the patient is in use without any sense of discomfort, and also imperceptible have foreign body to exist; And because this film is water white, so can clearly observe the progression of disease situation in affected part; In case need stop treatment, the formed film of this liniment can be removed from skin easily.Thereby film former and bioadhesive polymer are not used in combination the instruction that obtains after application, can to obtain to have the gelatinous external liniment of good adhesiveness, breathability, water white stealthy film in the prior art.
The formed film of this liniment can also effectively absorb the exudate in affected part, reduces sense of discomfort and can reduce transudate to make the affected part that the danger of ulcer take place.Simultaneously; the formed film of liniment of the present invention can also be protected the skin of lesions position effectively; make it to avoid external pollution and friction stimulation; avoid cross infection; and can keep being capped the moisture of position skin in right amount; thereby soften cuticle increases medicine to the infiltration of skin than the depths focus.
The objective of the invention is to provide a kind of film former of active component, some and external liniment of bioadhesive polymer of comprising, this liniment also preferably comprises the volatile solvent, and can randomly comprise external preparation such as plasticizer, cutaneous permeable agent, antiseptic additive commonly used.
The definition of used among the present invention " bioadhesion " refer to biological or synthetic material adhesion on the skin and/or mucosa of biology, thereby this material can be retained the more normal time thereon.The definition of " bioadhesive polymer " refers to the material with bioadhesive among the present invention.The definition of " stealthy film " refers to a kind of water white film among the present invention.
The present composition contains and accounts for composition total weight 2% to 30% weight, the film former of preferred 5%-15% weight.Employed film former is commonly usedly in the prior art to have an excellent biological compatibility, nontoxic, non-stimulated in the present composition, filmogen with pliability, hygroscopicity and water solublity or fat-soluble characteristics comprises the group of polyvinyl alcohol (PVA), ethylene-vinyl acetate copolymer (EVA), polyvinylpyrrolidone, Pioloform, polyvinyl acetal, methacrylate-methacrylic acid copolymer, hydroxypropyl cellulose, hypromellose, polyvidone.The polyvinyl alcohol of preferred various models (PVA) as PVA124,04-86,05-88,07-88,17-88 or its mixture, more preferably is PVA04-86 and PVA17-88.PVA can obtain by commercial sources.
The present composition contains and accounts for composition total weight 0.5%-20% weight, the bioadhesive polymer of preferred 0.5%-5% weight.Employed bioadhesive polymer can be selected from the group that comprises polyacrylic acid, polymethylacrylic acid, carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone, tragcanth, sodium alginate, HPMC in the present composition.Preferred biological safety is good, the polyacrylic acid crosslinked resin that adhesiveness is good.Polyacrylic acid crosslinked resin is a kind of acrylic acid crosslinked resin, the copolymer of particularly poly-alkyl sucrose or poly-alkyl tetramethylolmethane and acrylic crosslinking polymer, carbomer (Carbopol) for example, the present invention can use the carbomer of various models, as carbomer 934,940,910 or its mixture, preferred carbomer 934 and 940.Carbomer can obtain by commercial sources, for example can buy with the title of Carbopol from BF Goodrich company.
The present composition preferably contains and accounts for composition total weight 5%-30% weight, the volatile solvent of preferred 10%-30% weight.Employed volatile solvent has for example ethanol, acetone, ethyl acetate, isopropyl alcohol, cyclohexane extraction or their mixture, preferred alcohol, acetone or its mixture in the present composition.
The present composition preferably contains and accounts for composition total weight 1%-20% weight, the plasticizer of preferred 2%-10% weight.Employed plasticizer has for example glycerol, propylene glycol, dibutyl phthalate or its mixture in the present composition, preferably glycerine, propylene glycol or its mixture, be the mixture of glycerol and propylene glycol more preferably, for example it is with 0.5: 1-1: the mixture that 3 ratio forms.
Compositions of the present invention can also randomly comprise antiseptic and/or cutaneous permeable agent, suitable antiseptic has for example methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben or its mixture, hydroxy benzoate, propyl parabene, one or more in the group of a phenyl methylcarbamate; Suitable cutaneous permeable agent has for example azone, dimethyl sulfoxide, carbamide, propylene glycol or its mixture, preferred dimethyl sulfoxide, azone, propylene glycol, with and composition thereof.The content of antiseptic is about 0.001%-0.5% weight of said composition gross weight.The content of cutaneous permeable agent is about 0.1%-40% weight of said composition gross weight.
Can also comprise adjuvant commonly used in the pharmaceutical preparation prior aries such as pH regulator agent, correctives in the preparation of the present invention so that preparation of the present invention has pleasant fragrance and suitable character such as Ph value, the selection of these materials and interpolation all are well-known to those skilled in the art, wherein said pH regulator agent such as sodium hydroxide solution, triethanolamine etc.
Liniment of the present invention can comprise the various dermatosis that are used for the treatment of, analgesic drug product, the active component of aesthetic health care etc., wherein said dermatosis is antibacterial or the caused dermatosis of fungal infection for example, used active component is that the prior art kind is commonly used, for example treat the azole (imidazoles and triazole) of fungal infection, propylamine, sulfo-amino methyl ester class, the thebaine class, pyrrones, miazines or the like or their mixture, bifonazole for example, terbinafine, amorolfine, ciclopirox olamine, clotrimazole, miconazole, ketoconazole, econazole, tioconazole, selenium sulfide, Nystatin, amphotericin B or their mixture, preferred bifonazole, terbinafine, amorolfine, ciclopirox olamine.Antipsoriatics thing for example: tretinoin, isotretinoin, tazarotene, preferred tretinoin.Hormones such as skin adrenocortical hormone comprise dexamethasone, fluocinolone acetonide, Mo Tamisong, clobetasol propionate, halometasone, halcinonide, triamcinolone acetonide or their mixture.Antiviral drugs for example: phthiobuzone, ribavirin, acyclovir, penciclovir or their mixture; Anti-inflammatory analgesic class material: ibuprofen and derivant thereof, diclofenac sodium, naproxen, piroxicam, acetaminophen, etofenamate, indomethacin or their mixture.Active component of the present invention can be selected as required by those skilled in the art, can use one or more active component.As required active component and application dose thereof are selected will be apparent to those skilled in the art, can change according to the factors such as the order of severity of treatment disease, this variation also within the scope of the invention.
The amount of contained active component can be selected with reference to clinical dosage commonly used as required in the preparation of the present invention, the amount of active component can be according to many factors, in very wide scope, select, the character of wherein said factor such as selected active component, the disease of being treated, the application purpose of preparation etc., this selection is known to those skilled in the art, as a reference, the quantity of active component can be 0.00001% to 20% weight of composition weight, the antifungal drug that for example can contain 0.5% to 10% weight, or the antiviral drugs of 0.1% to 10% weight.
In one embodiment of the invention, the content of active component is the 1-10% weight of composition total weight in this liniment, the content of filmogen is the 2%-30% weight of composition total weight, and the content of bioadhesive polymer is the 0.5%-10% of composition total weight.In preferred embodiments, the content of filmogen is the 5%-15% weight of composition total weight, and the content of bioadhesive polymer is the 0.5%-5% weight of composition total weight.In another preferred embodiment, the content of active component is 1% weight of composition total weight in this liniment, the content of filmogen is the 10%-15% weight of composition total weight, and the content of bioadhesive polymer is the 0.5%-5% weight of composition total weight.
In embodiment preferred of the present invention, this liniment also contains the plasticizer of the 5%-20% weight that accounts for composition total weight.
In one embodiment of the invention, this liniment contains antiseptic that accounts for composition total weight 0.001%-0.5% weight and/or the cutaneous permeable agent that accounts for composition total weight 0.1%-40% weight.
The present invention also provides a kind of method for preparing described liniment, and it comprises the steps:
(1) filmogen is added water-soluble expanding, place the back of spending the night and in 90 ℃ water-bath, heat swelling, make gel;
(2) bioadhesive polymer is added water-soluble expanding, placement is spent the night, and makes gel;
(3) take by weighing in the active component adding ethanol of requirement, make suspension, join immediately in the gel of (1), stir so that its homodisperse through supersound process;
(4) gel with (2) adds in the gel of (3), stirs rapidly, and mix homogeneously is transferred pH to 4-7, obtains transparent or white gels;
This gel is carried out packing with the flexible pipe of required specification to get final product.
The present invention also provides the method for the described liniment of another kind of preparation, and it comprises the steps:
(1) filmogen is added water-soluble expanding, place the back of spending the night and in 90 ℃ water-bath, heat swelling, make gel;
(2) bioadhesive polymer is added water-soluble expanding, placement is spent the night, and makes gel;
(3) take by weighing in the active component adding ethanol of requirement, make suspension, join immediately in the gel of (1), stir so that its homodisperse through supersound process;
(4) in the gel of (3), add plasticizer, mix homogeneously;
(5) gel with (2) adds in the gel of (4), stirs rapidly, and mix homogeneously is transferred pH to 4-7, obtains transparent or white gels;
This gel is carried out packing with the flexible pipe of required specification to get final product.
The present invention also provides a kind of method for preparing described liniment, and it comprises the steps:
(1) filmogen is added water-soluble expanding, place the back of spending the night and in 90 ℃ water-bath, heat swelling, make gel;
(2) bioadhesive polymer is added water-soluble expanding, placement is spent the night, and makes gel;
(3) antiseptic is dissolved in the ethanol, gained solution is joined in the gel of (1) mix homogeneously;
(4) take by weighing in the active component adding ethanol of requirement, make suspension, join immediately in the gel of (3), stir so that its homodisperse through supersound process;
(5) in the gel of (4), add plasticizer and/or cutaneous permeable agent, mix homogeneously;
(6) gel with (2) adds in the gel of (5), stirs rapidly, and mix homogeneously is transferred pH to 4-7, obtains transparent or white gels;
This gel is carried out packing with the flexible pipe of required specification to get final product.
When using the liniment of the milky gel form of gained evenly is applied in the affected part and gets final product, it is a drying and forming-film after 2-5 minute.
The gained liniment can be preserved with the medicinal flexible pipe packing of different size.
Liniment of the present invention can be used for dermatosis, for example all kinds of tinea, herpes etc.; Fields such as externally applied analgetic, wound, health and beauty.
Now the present invention is further detailed with the following examples.
Embodiment
Embodiment 1
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| ????PVA04-86 | ??????6.7 |
| ????PVA17-88 | ??????6.7 |
| Acritamer 940 | ??????1 |
| Glycerol | ??????3.3 |
| Propylene glycol | ??????5 |
| Azone | ??????2 |
| Ethyl hydroxybenzoate | ??????0.1 |
| Ethanol | ??????13 |
| 10% sodium hydroxide | ??????1ml |
| Water | ??????61.2 |
| Amount to | ??????100 |
This liniment can form water white thin film after 2-5 minute, the film forming good toughness of institute's shape has been difficult for the limit, and rub resistance can peel off when specially removing.
The antifungal drug that adds 1%-5% respectively as bifonazole, terbinafine, amorolfine, is made the antifungal haptogen.
Try out for respectively 10 tinea pedis, tinea corporis patient bifonazole, terbinafine, after medication 1-2 week, the hypertrophy cutin of affected skin has clear improvement with chapping, and 4 weeks were almost recovered.Said preparation has played good focus buffer action, and its hidden property does not affect the appearance simultaneously, has avoided cross infection again, has prolonged the action time of medicine.
Embodiment 2
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| ????PVA05-88 | ??????10 |
| Acritamer 940 | ??????1 |
| Glycerol | ??????3.3 |
| Propylene glycol | ??????1 |
| Azone | ??????2 |
| Nipagin | ??????0.16 |
| Propyl parabene, | ??????0.017 |
| Between phenyl methylcarbamate | ??????0.086 |
| Ethanol | ??????13 |
| Triethanolamine | In right amount, transfer pH to 6 |
| Water | ??????65.3 |
| Amount to | ??????100 |
This liniment can form water white thin film after 2-5 minute, the film forming good toughness of institute's shape has been difficult for the limit, and rub resistance can peel off when specially removing.
By required different purposes, add different types of active medicine, it is carried out packing with flexible pipe.
Embodiment 3
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| ????PVA04-86 | ??????5 |
| Carbomer 934 | ??????3 |
| Glycerol | ??????3 |
| Propylene glycol | ??????5 |
| Dimethyl sulfoxide | ??????0.6 |
| Carbamide | ??????10 |
| Methyl hydroxybenzoate | ??????0.1 |
| Propylparaben | ??????0.1 |
| 95% ethanol | ??????20 |
| Water | In right amount |
By required different purposes, add different types of active medicine, it is carried out packing with flexible pipe.
Obtain having the liniment of above-mentioned character.
Embodiment 4
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| ????PVA04-86 | ????????4 |
| ????PVA17-88 | ????????4 |
| Carbomer 934 | ????????2 |
| Glycerol | ????????6 |
| Dimethyl sulfoxide | ????????0.4 |
| Parachlorometaxylenol | ????????0.05 |
| Triethanolamine | In right amount, transfer pH to 6 |
| Ethanol | ????????20 |
| Water | In right amount |
Obtain having the liniment of above-mentioned character.
Embodiment 5
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| Amorolfine | ???????5 |
| ????PVA17-88 | ???????5 |
| Acritamer 940 | ???????1 |
| Glycerol | ???????6 |
| Dimethyl sulfoxide | ???????0.4 |
| Ethyl hydroxybenzoate | ???????0.1 |
| Triethanolamine | In right amount, transfer pH to 6 |
| Ethanol | ???????26 |
| Water | In right amount |
Obtain having the liniment of above-mentioned character.According to different demands, add required medicine.
Embodiment 6
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| Bifonazole | ??????1 |
| ????PVA04-86 | ??????1.25 |
| ????PVA17-88 | ??????3.75 |
| Acritamer 940 | ??????3 |
| Dimethyl sulfoxide | ??????0.4 |
| Carbamide | ??????5 |
| Sorbic acid | ??????0.2 |
| Triethanolamine | In right amount, transfer pH to 6 |
| Ethanol | ??????????30 |
| Water | In right amount |
Obtain having the liniment of above-mentioned character.
Embodiment 7
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| Phthiobuzone | ?????1 |
| ????PVA04-86 | ?????11.25 |
| ????PVA17-88 | ?????3.75 |
| Acritamer 940 | ?????2 |
| Dimethyl sulfoxide | ?????0.4 |
| Ethyl hydroxybenzoate | ?????0.1 |
| Ethanol | ?????20 |
| Acetone | ?????10 |
| Water | In right amount |
This liniment is used for the treatment of the herpes that viral infection causes.Avoid cross infection, evident in efficacy.
Embodiment 8
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| Ibuprofen | ????????5 |
| ????PVA124 | ????????10 |
| Acritamer 940 | ????????1.5 |
| Dimethyl sulfoxide | ????????0.5 |
| Carbamide | ????????10 |
| Sorbic acid | ????????0.2 |
| Sodium hydroxide | In right amount, transfer pH to 6 |
| Ethanol | ???30 |
| Water | In right amount |
Be used for the treatment of psoriasis, can avoid the friction of medicated clothing and diseased region, improve curative effect.
Embodiment 9
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| Acyclovir | ?????3 |
| ????PVA04-86 | ?????3.75 |
| ????PVA17-88 | ?????4 |
| Acritamer 940 | ?????1 |
| Propylene glycol | ?????2 |
| Azone | ?????2 |
| Glycerol | ?????3 |
| Sodium hydroxide | In right amount, transfer pH to 6 |
| Ethanol | ?????13 |
| Water | In right amount |
Be used for the treatment of the herpes that virus causes, can avoid the friction of medicated clothing and diseased region, avoid cross infection, improve cure rate.
Embodiment 10
Prepare a kind of liniment of the present invention by following prescription according to above-mentioned corresponding method.
| Composition | Quantity % weight |
| Tretinoin | ?????0.025 |
| ????PVA124 | ?????5 |
| Acritamer 940 | ?????1.5 |
| Propylene glycol | ?????5 |
| Azone | ?????3 |
| ???BHT | ?????0.1 |
| Ethanol | ???18 |
| Water | In right amount |
Be used for the treatment of psoriasis, can avoid the friction of medicated clothing and diseased region, improve curative effect.
Embodiment 11
The skin irritation Journal of Sex Research of stealthy film
1. test objective:
The irritant reaction situation that is produced behind observer's rabbit skin contact test sample.
2. test material:
2.1 test sample:
Stealthy film, lot number is 200300311.Main component comprises: carbomer, glycerol, propylene glycol, PVA, azone, Nipagin ester, ethanol, water.
2.2 reference substance: medical ventolin, Shanghai China is paraffin company limited product forever, lot number: 20030319,2 years shelf-lifves.
2.3 animal:
Animal strain: new zealand rabbit.
Body weight: 2.0～3.0kg.
Sex: male.
Number of animals: totally 12.
Animal identification: adopt thorn to dye overbit identification.
3. dosage:
Respectively be coated with 1g stealthy film, vaseline, continuous 7 day to rabbit every day.
4. route of administration:
Adopt the clinical administration approach, the skin coating.
5. test method:
24hr takes off tame rabbit back vertebra diamond wool with electric clipper the about 50cm of every lateral area before the administration
2" ten " notched cut is done with the sterile surgical cutter by the damaged skin district at epidermis.Respectively each 1g of stealthy film is applied to the administration group, each 1g of excipient is applied to the excipient matched group, and vaseline 1g is applied to the vaseline matched group, once a day, and continuous 7 days.Before each repeat administration,, and observe and smear the position and have or not situations such as erythema and edema with warm water flush away administration last time left drug.Finish back 24hr in administration and remove residual medicine with warm water, respectively at removal be subjected to behind the reagent thing 1,24,48,72hr observes and smears recovery situation and the time that the position has or not situation such as erythema and edema and above-mentioned variation.
6. observation index:
Local excitation reaction: perusal skin erythema and edema.
7. evaluation of result:
Skin irritation reaction press table 1 and is marked, and carries out the stimulus intensity evaluation by table 2 after calculating mean scores.
Table 1 skin irritation reaction scoring
The irritant reaction score value
Erythema
No erythema 0
Inadequate visible 1
Moderate erythema 2
Serious erythema 3
The aubergine erythema also has eschar to form 4
Edema
No edema 0
Inadequate visible 1
Cutaneous protuberance profile clear 2
Edema about 1mm of protuberance and expanded range 4
Total points 8
Table 2 skin irritation intensity evaluation
The intensity score value
Nonirritant＜0.5
Slight zest＜2.1
Moderate zest＜6.0
Intensity zest＞6.0
8. result:
Observe animal skin change intact skin irritant test mean scores every day during the administration:
Blank group: 0.042
Stealthy film group: 0.208
Damaged skin irritant test mean scores:
Blank group: 0
Stealthy film group: 0.375
9. conclusion:
Complete and the damaged skin of rabbit contacts vaseline repeatedly, and behind the stealthy film, intact skin stimulus intensity mean scores is respectively 0.042,0.208, and the damaged skin mean scores is respectively 0,0.375.Stealthy film is to rabbit skin nonirritant.
Claims (29)
1. an external preparation composition is characterized in that it comprises the active component of effective drug level, filmogen, bioadhesive polymer.
2. preparation as claimed in claim 1 is characterized in that it is the gel liniment, in that be coated on the skin just can be dry voluntarily after 2-5 minute, form the stealthy film of uniform, water white, wear-resisting wiping and begins to discharge medicine.
3. liniment as claimed in claim 1 or 2 is characterized in that wherein the content of filmogen is the 2%-30% weight of composition total weight, and the content of bioadhesive polymer is the 0.5%-20% weight of composition total weight.
4. liniment as claimed in claim 3, the content that it is characterized in that filmogen are the 5%-15% weight of composition total weight, and the content of bioadhesive polymer is the 0.5%-5% weight of composition total weight.
5. as any described preparation of claim in front, it is characterized in that wherein said filmogen is selected from the group of the polyvinyl alcohol (PVA) that comprises various models, ethylene-vinyl acetate copolymer (EVA), polyvinylpyrrolidone, Pioloform, polyvinyl acetal, methacrylate-methacrylic acid copolymer, hydroxypropyl cellulose, hypromellose, polyvidone; And/or said bioadhesive polymer is selected from the copolymer of poly-alkyl sucrose or poly-alkyl tetramethylolmethane and acrylic crosslinking polymer, cellulosic polymer, tragcanth, sodium alginate and/or their mixture.
6. liniment as claimed in claim 5 is characterized in that wherein said filmogen is selected from polyvinyl alcohol or its mixture of various models; And/or said bioadhesive polymer is selected from carbomer 934,940,910 or its mixture.
7. liniment as claimed in claim 6 is characterized in that wherein said filmogen is selected from PVA124, PVA04-86, PVA05-88, PVA07-88, PVA17-88 or its mixture; And/or said bioadhesive polymer is selected from Acritamer 940.
8. liniment as claimed in claim 1 or 2 is characterized in that wherein containing the volatile solvent that accounts for composition total weight 5%-30% weight.
9. liniment as claimed in claim 8 is characterized in that wherein contained volatile solvent is selected from ethanol, acetone, ethyl acetate, isopropyl alcohol, cyclohexane extraction or their mixture.
10. liniment as claimed in claim 1 or 2 is characterized in that it contains the plasticizer that accounts for composition total weight 5%-20%.
11. compositions as claimed in claim 10 is characterized in that wherein said plasticizer is selected from glycerol, propylene glycol, dibutyl phthalate or their mixture.
12. liniment as claimed in claim 1 or 2 is characterized in that it also comprises antiseptic and/or Percutaneous absorption enhancer.
13. liniment as claimed in claim 12 is characterized in that wherein containing the antiseptic that accounts for composition total weight 0.001%-0.5% weight and/or accounts for the cutaneous permeable agent of coating combination gross weight 0.1%-40% weight.
14. liniment as claimed in claim 13, wherein antiseptic is selected from one or more in the group that comprises methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, sorbic acid, hydroxy benzoate, propyl parabene, a phenyl methylcarbamate.
15., it is characterized in that wherein said cutaneous permeable agent is selected from azone, dimethyl sulfoxide, carbamide, propylene glycol or their mixture as any described liniment of claim 13-14.
16., but it is characterized in that wherein said active component is selected from the active component of external used medicine as any described liniment of claim in front.
17. liniment as claimed in claim 16, it is characterized in that comprise effective drug level active component be antibiotic.
18. antibiotic as claimed in claim 17 refers to antifungal drug.Wherein said active component is selected from bifonazole, terbinafine, amorolfine, ciclopirox olamine, clotrimazole, miconazole, ketoconazole, econazole, tioconazole, selenium sulfide, Nystatin, amphotericin B or their mixture.
19. liniment as claimed in claim 16, it is characterized in that comprise effective drug level active component be hormone.
20. hormone as claimed in claim 19 refers to the skin adrenocortical hormone, comprises dexamethasone, fluocinolone acetonide, Mo Tamisong, clobetasol propionate, halometasone, halcinonide, triamcinolone acetonide or their mixture.
21. liniment as claimed in claim 16, it is characterized in that comprise effective drug level active component be treatment psoriasis class material.
22. treatment psoriasis class material as claimed in claim 21, it is characterized in that comprise effective drug level active component comprise tretinoin, isotretinoin, etretinate, calcipotriol, resorcin, tazarotene and coal tar.
23. liniment as claimed in claim 16, it is characterized in that comprise effective drug level active component be antiviral class material.
24. as antiviral drugs as described in the claim 23, it is characterized in that comprise effective drug level active component comprise phthiobuzone, ribavirin, acyclovir, penciclovir or their mixture.
25. liniment as claimed in claim 16, it is characterized in that comprise effective drug level active component be anti-inflammatory analgesic class material.
26. as anti-inflammatory analgesic class medicine as described in the claim 25, it is characterized in that comprise effective drug level active component comprise ibuprofen and derivant, diclofenac sodium, naproxen, piroxicam, acetaminophen, etofenamate, indomethacin or their mixture.
27. one kind prepares the method for liniment as claimed in claim 1 or 2, it is characterized in that it comprises following steps:
(1) filmogen is added water-soluble expanding, place the back of spending the night and in 90 ℃ water-bath, heat swelling, make gel;
(2) bioadhesive polymer is added water-soluble expanding, placement is spent the night, and makes gel;
(3) take by weighing in the active medicine adding ethanol of requirement, make suspension, join immediately in the gel of (1), stir so that its homodisperse through supersound process;
(4) gel with (2) adds in the gel of (3), stirs rapidly, and mix homogeneously obtains transparent or white gels.
28. one kind prepares the method for liniment as claimed in claim 1 or 2, it is characterized in that it comprises following steps:
(1) filmogen is added water-soluble expanding, place the back of spending the night and in 90 ℃ water-bath, heat swelling, make gel;
(2) bioadhesive polymer is added water-soluble expanding, placement is spent the night, and makes gel;
(3) take by weighing in the active medicine adding ethanol of requirement, make suspension, join immediately in the gel of (1), stir so that its homodisperse through supersound process;
(4) in the gel of (3), add plasticizer and/or cutaneous permeable agent, mix homogeneously;
(5) gel with (2) adds in the gel of (4), stirs rapidly, and mix homogeneously obtains transparent or white gels.
29. one kind prepares the method for liniment as claimed in claim 1 or 2, it is characterized in that it comprises following steps:
(1) filmogen is added water-soluble expanding, place the back of spending the night and in 90 ℃ water-bath, heat swelling, make gel;
(2) bioadhesive polymer is added water-soluble expanding, placement is spent the night, and makes gel;
(3) antiseptic is dissolved in the ethanol, gained solution is joined in the gel of (1) mix homogeneously;
(4) take by weighing in the active medicine adding ethanol of requirement, make suspension, join immediately in the gel of (3), stir so that its homodisperse through supersound process;
(5) in the gel of (4), add plasticizer and/or cutaneous permeable agent, mix homogeneously;
(6) gel with (2) adds in the gel of (5), stirs rapidly, and mix homogeneously is transferred pH to 4-7, obtains transparent or white gels.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100377305A CN1316965C (en) | 2003-08-06 | 2004-05-10 | Transparent disappearing external administration carrier |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN03149772.1 | 2003-08-06 | ||
| CNA031497721A CN1480128A (en) | 2003-08-06 | 2003-08-06 | Preparation of transparent, cryptomorphic external remedy |
| CNB2004100377305A CN1316965C (en) | 2003-08-06 | 2004-05-10 | Transparent disappearing external administration carrier |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1579373A true CN1579373A (en) | 2005-02-16 |
| CN1316965C CN1316965C (en) | 2007-05-23 |
Family
ID=34593084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100377305A Active CN1316965C (en) | 2003-08-06 | 2004-05-10 | Transparent disappearing external administration carrier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1316965C (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919828A (en) * | 2010-08-19 | 2010-12-22 | 夏志慧 | Transdermal absorption adhesive patch for curing onychomycosis and preparation method thereof |
| CN102258455A (en) * | 2010-05-28 | 2011-11-30 | 上海市计划生育科学研究所 | Film coating agent containing steroid hormone and its preparation method |
| CN103989626A (en) * | 2014-05-05 | 2014-08-20 | 江苏圣宝罗药业有限公司 | Aciclovir gel composition with improved performance |
| CN105434404A (en) * | 2015-12-18 | 2016-03-30 | 江苏海智生物医药有限公司 | Film coating agent used for protecting wound surfaces |
| CN105853344A (en) * | 2015-02-09 | 2016-08-17 | 晶化生技医药股份有限公司 | Film-forming gel composition |
| CN105998248A (en) * | 2016-05-17 | 2016-10-12 | 北华大学 | Frostbite liniment containing Changbai mountain prunus tomentosa |
| CN106420672A (en) * | 2016-11-06 | 2017-02-22 | 成都先先先生物科技有限公司 | Piroxicam film coating agent and preparation method thereof |
| CN106474093A (en) * | 2015-08-27 | 2017-03-08 | 重庆华邦制药有限公司 | Desonide liniment and preparation method thereof |
| CN107184505A (en) * | 2017-05-05 | 2017-09-22 | 浙江省海洋开发研究院 | A kind of natural anti-oxidation face cream and preparation method thereof |
| CN108815569A (en) * | 2018-06-20 | 2018-11-16 | 北京点域科技有限公司 | A kind of medical type wound repairs the preparation method of liquid |
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Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ419099A0 (en) * | 1999-11-23 | 1999-12-16 | Ko, Thomas Sai Ying | Novel compositions and methods |
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2004
- 2004-05-10 CN CNB2004100377305A patent/CN1316965C/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102258455A (en) * | 2010-05-28 | 2011-11-30 | 上海市计划生育科学研究所 | Film coating agent containing steroid hormone and its preparation method |
| CN102258455B (en) * | 2010-05-28 | 2014-09-17 | 上海市计划生育科学研究所 | Film coating agent containing steroid hormone and its preparation method |
| CN101919828A (en) * | 2010-08-19 | 2010-12-22 | 夏志慧 | Transdermal absorption adhesive patch for curing onychomycosis and preparation method thereof |
| CN103989626A (en) * | 2014-05-05 | 2014-08-20 | 江苏圣宝罗药业有限公司 | Aciclovir gel composition with improved performance |
| CN103989626B (en) * | 2014-05-05 | 2018-12-18 | 江苏知原药业有限公司 | A kind of Aciclovir Gel composition of performance improvement |
| CN105853344B (en) * | 2015-02-09 | 2020-06-23 | 晶化生技医药股份有限公司 | Film-forming gel composition |
| CN105853344A (en) * | 2015-02-09 | 2016-08-17 | 晶化生技医药股份有限公司 | Film-forming gel composition |
| CN106474093A (en) * | 2015-08-27 | 2017-03-08 | 重庆华邦制药有限公司 | Desonide liniment and preparation method thereof |
| CN105434404B (en) * | 2015-12-18 | 2018-07-17 | 江苏海智生物医药有限公司 | A kind of plastics for protecting wound surface |
| CN105434404A (en) * | 2015-12-18 | 2016-03-30 | 江苏海智生物医药有限公司 | Film coating agent used for protecting wound surfaces |
| CN105998248A (en) * | 2016-05-17 | 2016-10-12 | 北华大学 | Frostbite liniment containing Changbai mountain prunus tomentosa |
| CN106420672A (en) * | 2016-11-06 | 2017-02-22 | 成都先先先生物科技有限公司 | Piroxicam film coating agent and preparation method thereof |
| CN109952201A (en) * | 2016-11-09 | 2019-06-28 | Csp技术公司 | The polymer and its manufacturing method of the entrainment mineral of film coating |
| CN109952201B (en) * | 2016-11-09 | 2021-04-13 | Csp技术公司 | Film coated mineral-entrained polymers and methods of making the same |
| CN107184505A (en) * | 2017-05-05 | 2017-09-22 | 浙江省海洋开发研究院 | A kind of natural anti-oxidation face cream and preparation method thereof |
| CN108815569A (en) * | 2018-06-20 | 2018-11-16 | 北京点域科技有限公司 | A kind of medical type wound repairs the preparation method of liquid |
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| CN1316965C (en) | 2007-05-23 |
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Effective date of registration: 20140714 Address after: 100089 Beijing city Haidian District landianchang road Newton office room 905 Patentee after: Yangxin Sci-Tech Co., Ltd., Beijing Patentee after: JIANGSU JINBIAO SHIJI BIOTECHNOLOGY CO., LTD. Address before: 100089 Beijing city Haidian District landianchang road Newton office room 905 Patentee before: Yangxin Sci-Tech Co., Ltd., Beijing |
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Address after: Room 905, Newton Office District, Lanindichang South Road, Haidian District, Beijing Co-patentee after: Jiangsu Yang Xin Biological Medicine Co., Ltd. Patentee after: Yangxin Sci-Tech Co., Ltd., Beijing Address before: Room 905, Newton Office District, Lanindichang South Road, Haidian District, Beijing Co-patentee before: JIANGSU JINBIAO SHIJI BIOTECHNOLOGY CO., LTD. Patentee before: Yangxin Sci-Tech Co., Ltd., Beijing |