RU2475244C1 - Agent antiactinomycilline for treating actinomycosis and necrobacillosis in farm animals - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to veterinary science. The agent contains, wt %: wildflower honey 3.0-5.0, pine turpentine 5.0-8.0, melted (cow) butter 12.0-15.0, anaesthesine 0.5-1.0, glycerol 0.5-1.5, ethanol 20.0-25.0, potassium iodide 2.0-2.5, salicylic acid 3.0-5.0, 9% vinegar 6.0-8.0, Novocaine (powder) 1.0-1.5, distilled water - the rest.

EFFECT: use of the declared agent enables higher clinical effectiveness in actinomycosis and necrobacteriosis, improved immunobiological properties of animal's body, reduced length of recovery.

1 tbl, 4 ex

Description

The invention relates to veterinary medicine, namely to the treatment of actinomycosis and necrobacteriosis of farm animals.

Currently, the problem is the treatment of such a disease in cattle as actinomycosis, a chronic infectious disease of animals caused by actinomycetes (radiant fungi), the main form of manifestation of which is infectious granuloma.

Known drug for the prevention and treatment of animal necrobacillosis - an aqueous solution of methanol-formaldehyde water, methylalanolic fraction, high-boiling product is treated on the limbs of animals (patent RU No. 20111380, A61K 31/05, 1994).

Known use in veterinary practice for the treatment of fungal diseases of animals of elemental sulfur (temporary instruction on the use of a comprehensive method for the treatment of demodicosis, 1990).

Known medical veterinary drug, in which the active substance is an antiseptic is used elemental sulfur and filler (US Pat. RU No. 2030868, A61K 31/05, 1995).

However, the listed drugs have not a sufficiently high therapeutic effect, a narrow spectrum of action and relatively long periods of treatment.

There is also known a tool for treating deep, extensive burns and infected wounds and ulcers and this balm is an ointment that contains polyfler flower honey, pine resin and ghee (cow) oil (US Pat. RU No. 2168999, A61K 35/64, A61K 9/06 A61P 17/02 2001).

Although this ointment, which is closest to the one proposed, softens and resolves the inflammatory process, it does not sufficiently neutralize the vast deep affected tissues of the actinomycoma micelle (filament).

When creating the invention, the task was to obtain such a tool for the treatment of actinomycosis, which would completely neutralize and improve the immunobiological properties of the animal organism and reduce the time of their recovery.

This is achieved by the fact that anesthetics, glycerin, ethyl alcohol, potassium iodide, salicylic acid, 9% table vinegar are added to the agent for treating actinomycosis and necrobacteriosis of farm animals, including polyfler flower honey, pine resin, ghee (cow) oil , novocaine (powder) and distilled water in the following ratio of components, wt.%:

Polyfloral Flower Honey 3.0-5.0 Zhivitsa pine 5.0-8.0 Ghee (cow) butter 12.0-15.0 Anestezin 0.5-1.0 Glycerol 0.5-1.5 Ethanol 20.0-25.0 Potassium iodide 2.0-2.5 Salicylic acid 3.0-5.0 9% table vinegar 6.0-8.0 Novocaine (powder) 1.0-1.5 Distilled water rest

Signs that distinguish the proposed product from the closest patent of the Russian Federation No. 2168999 to it, characterize the presence of anestezin, glycerin, ethyl alcohol, potassium iodide, salicylic acid, 9% table vinegar, novocaine (powder) and distilled water, which allows to increase the therapeutic effect , immunological properties, activate the regenerative process, neurovascular reactions of affected tissues, enhance the bactericidal action of the drug.

The proposed tool "Antiactinomyllin" is obtained as follows. Salicylic acid, potassium iodide are dissolved in ethanol, anestezin, novocaine in distilled water, then in acetic acid 9% and glycerin. After that, the resulting solutions are mixed, and polyfler flower honey, pine resin and melted (cow) oil, preheated in a water bath at a temperature of 45-50 ° C, are added to the resulting solution, mixed thoroughly until a homogeneous mass is obtained and packaged. The components are mixed according to the formulations indicated in the table.

Only such a recipe for mixing the components provides 100% disinfection and recovery of animals, when using a recipe less than the minimum, the necessary efficiency is not achieved, and using the recipe more than the maximum is impractical, because treatment effectiveness remains the same - i.e. one hundred%.

The liquid warm solution of "Antiactinomycillin" is administered once under the base with actinomics located in the head, neck and other parts of the body to a depth of 0.5 to 12 cm, diameter from 3 to 12 cm at 2-4 points in a dose of 5-30 ml (at one point 4-8 ml), into the abscess cavity from 4 to 8 ml. A single administration of the drug under the basis of actinomycoma or in the center of the abscess ensures complete disinfection and neutralization of the infected tissues, does not violate their normal trophic and functional ability of the neurovascular reaction, the productivity of the animals is fully preserved.

Actinomycosis treatment measures were carried out on cattle of different ages in 30 households in 16 districts of the Republic of Tatarstan.

Example 1. In the collective enterprise "Cheremukhovskoye" RT, 500 heads of dairy cows had actinomics in the head and neck, 10-12 cm deep, which were removed by surgery, 2 surgeons, 6 fixators participated, the time spent on one animal was 2, 5 hours, the same time is required for re-processing, and, in addition, a large number of medical and dressing materials are required. Applied in the form of drainage into the wound balm ointment (taken as a prototype of Pat. RU No. 2168999), the process of repairing damaged tissue occurs within 7-10 days, however, the left drusen radiant fungus cause the maturation of a new granuloma.

Example 2. At the same enterprise, 158 dairy cows had actinomicomas in the head and neck area with a depth of 10-12 cm, a warm liquid solution of the proposed “Antiactinomycillin” agent was introduced under the base of actinomycoma in 4-6 points from 5 to 30 ml, to the center abscess from 4 to 8 ml once within 2-3 days after administration of the drug, an increase in swelling of the affected area was observed, which decreased in size on the fourth day. Deeply located granulomas were encapsulated, i.e. the formation of new metastases ceased. The introduction of the drug was carried out with one fixer, and it takes only 3 minutes per animal to administer it, 100% recovery of the animals was achieved, productivity was completely preserved and no further metastasis was observed.

Example 3. In a cooperative farm, actinomycosis was treated in 60 heads of dairy cows, 160 heifers, 40 calves. Actimicomas were located subcutaneously, intramuscularly with a depth of 0.5 to 12 cm, with a size of 3 to 8-12 cm in diameter to varying degrees of maturation, as well as opened abscesses. Under the base, an actinomic located in the head and neck, introduced the proposed tool "Antiactinomyllin" in a dose of 5 to 30 ml, and in the abscess cavity from 4 to 8 ml. After administration of the drug, an insignificant inflammatory edema was observed on the injection sheet for 2-3 days, which decreased in size on the fourth day, the general condition of the animals was satisfactory, and productivity remained. Actinomycomas, which are in the initial maturation process, completely disintegrated and absorbed, and during the abscess period they opened, cleaned without contaminating the environment, minor scars remained, and actinomycomas were completely disinfected in deeply located metastases.

Thus, the therapeutic actions of the proposed anti-actinomycillin means for disinfecting druze actinomycoma with a single injection under its base and into the abscess cavity give 100% disinfection and recovery of animals.

Example 4. The treatment of sick animals with necrobacillosis was carried out using the proposed “Antiactinomycillin” agent in 30 households in 16 regions of the Republic of Tatarstan. The drug was administered subcutaneously once in a warm form in the area of the corolla in a dose of 10 to 20 ml at 4 points from 3 to 5 ml at one point depending on the degree of damage. After administration of the drug at the injection site on the 2nd day, insignificant edema was observed, which disappeared on the 4th-6th days, and gradually was rejected on the 6-8th day. On days 12-16, the healing process ended with the complete restoration of the affected tissues. The effectiveness of the drug was 98.5%.

The proposed tool "Antiactinomyllin" has been successfully used in the treatment of acute chronic inflammatory processes with its external use in the form of a compress.

Claims (1)

A treatment for actinomycosis and necrobacteriosis of farm animals, including polyfler flower honey, pine resin, ghee (cow) oil, characterized in that it additionally contains anestezin, glycerin, ethyl alcohol, potassium iodide, salicylic acid, 9% table vinegar, novocaine (powder) and distilled water in the following ratio of components, wt.%:
polyfloral flower honey 3.0-5.0 pine resin 5.0-8.0 ghee (cow) butter 12.0-15.0 anestezin 0.5-1.0 glycerol 0.5-1.5 ethanol 20.0-25.0 potassium iodide 2.0-2.5 salicylic acid 3.0-5.0 9% table vinegar 6.0-8.0 novocaine (powder) 1.0-1.5 distilled water rest