CN104127396B - A kind of antibacterials and its preparation method and application - Google Patents
A kind of antibacterials and its preparation method and application Download PDFInfo
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- CN104127396B CN104127396B CN201410385945.XA CN201410385945A CN104127396B CN 104127396 B CN104127396 B CN 104127396B CN 201410385945 A CN201410385945 A CN 201410385945A CN 104127396 B CN104127396 B CN 104127396B
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Abstract
It is contemplated that open a kind of antibacterials and its preparation method and application, these antibacterials make simply, determined curative effect, expense are relatively low.The method is specially solution a, solution b and solution c under the constant temperature of 25 DEG C ~ 30 DEG C, completely cuts off aeroseal gained after 700:800:1 mixes by volume；What said method obtained is medicine stock solution, and above-mentioned stock solution can carry out proportioning use by functional requirement and other materials.The antibacterials manufacture method of the present invention is simple, and this medicine has broad spectrum antibacterial；And nontoxic, irritant pollution-free, without hormone, can apply in burn and scald, medical and beauty treatment, common surgical procedures and gynecological.
Description
Technical field
The present invention relates to a kind of antibacterials and its preparation method and application, belong to medicinal chemistry arts.
Background technology
Method and the medicine for the treatment of burn and scald are more at present, but curative effect differs, and treatment time is longer, can leave cicatrix after healing, and effect is undesirable.
Summary of the invention
It is contemplated that open a kind of antibacterials and its preparation method and application, the method makes simply, determined curative effect, expense are relatively low.The preparation method of these antibacterials be by solution a, solution b and solution c under the constant temperature of 25 DEG C ~ 30 DEG C, completely cut off aeroseal gained after 700:800:1 mixes by volume；Gained antibacterials are medicine stock solution, use after the volume ratio of the medicine stock solution of gained with water 1:10000 by volume being mixed during use；
Described solution a is that with ozone, pure water is processed 24h ~ 36h gained solution under the constant temperature of 25 DEG C ~ 30 DEG C；Water quality good penetrability treated by ozone, it is possible to penetrate into soft tissue, plays more preferable therapeutic effect；In described pure water, calcium content is less than 380mg/L；
Described solution b is that medical glycerol solution a is made the solution that glycerol concentration is 5/1000 ~ 10/1000；
Described solution c is the DDAC solution of 0.01% ~ 0.03%；The pH value of described solution c is 9 ~ 10.5.
Described antibacterials prepare for using said method.
Described constant temperature is 28 DEG C.
Described solution b is that medical glycerol solution a is made the solution that glycerol concentration is 8/1000.
Described solution c be 0.0218% DDAC solution.
The pH value of described solution c is 9.82.
The application in burn and scald, medical and beauty treatment, common surgical procedures and gynecological of the described antibacterials；Specially there is strong pain relieving, itching-relieving action, reduce the misery of burned patient；Mucosa, in the application of Gynecology, can be carried out painless antibacterial by these antibacterials, and antibacterial ability is higher than ethanol, and does not make mucosa injury, non-stimulated.Through Jilin Province, sanitary monitoring and testing work Spot detection draws: described antibacterials stock solution can 100% kill the pathogenic bacterium such as staphylococcus aureus, escherichia coli, Candida albicans；The bactericidal action time is 2min.Described antibacterials stock solution is to vaginal mucosa irritation index less than 1, and it is non-stimulated for stimulating rank.
Beneficial effects of the present invention: described antibacterials manufacture method is simple, and this medicine has broad spectrum antibacterial；And nontoxic, irritant pollution-free, without hormone, can apply in burn and scald, medical and beauty treatment, common surgical procedures and gynecological.The treatment of burn and scald can be shortened treatment cycle 3-5 times by this product, and medical treatment cost reduces by more than 10 times, and has strong pain relieving, itching-relieving action, reduce the misery of patient, it is a kind of new drug in burn and scald field, is greatly simplified the treatment difficulty of burn and scald, reduce medical expense 3-5 times of patient.Mucosa, in the application of Gynecology, can be carried out painless antibacterial by this product, and antibacterial ability is higher than ethanol, and does not make mucosa injury, non-stimulated.This product anemia of pregnant woman can normally use, and will not cause gene mutation.
Detailed description of the invention 1
One antibacterials of the present invention, described antibacterials contain the didecyldimethylammonium ammonia chloride of 0.01%, and during the preservation of antibacterials, didecyldimethylammonium ammonia chloride can preserve 90 days under the constant temperature of 37 DEG C.The preparation method of described antibacterials be by solution a, solution b and solution c under the constant temperature of 25 DEG C, completely cut off aeroseal gained after 700:800:1 mixes by volume；
Solution a is that with ozone, pure water is processed 24h gained solution under the constant temperature of 25 DEG C；Calcium content in pure water should reach country-level level, and in described pure water, calcium content is less than 380mg/L；Water quality good penetrability treated by ozone, it is possible to penetrate into soft tissue, plays more preferable therapeutic effect；
Solution b is that medical glycerol solution a is made the solution that glycerol concentration is 5/1000；
Solution c is the DDAC solution of 0.01%；The pH value of described solution c is 9；Antibacterials stock solution can add the lecithin of 0.3% as stabilizer.
Preparing this antibacterials by said method, antibacterials contain possibly together with a kind of novel substance in didecyldimethylammonium ammonia chloride, and described antibacterials, and described novel substance is the Organic substance containing aromatic hydrocarbon.
The application in burn and scald, medical and beauty treatment, common surgical procedures and gynecological of the described antibacterials；Specially there is strong pain relieving, itching-relieving action, reduce the misery of burned patient；Mucosa, in the application of Gynecology, can be carried out painless antibacterial by these antibacterials, and antibacterial ability is higher than ethanol, and does not make mucosa injury, non-stimulated.Through Jilin Province, sanitary monitoring and testing work Spot detection draws: described antibacterials stock solution can 100% kill the pathogenic bacterium such as staphylococcus aureus, escherichia coli, Candida albicans；The bactericidal action time is 2min.Described antibacterials stock solution is to vaginal mucosa irritation index less than 1, and it is non-stimulated for stimulating rank.
During use, after the volume ratio of the medicine stock solution of gained with water 1:10000 by volume being mixed, it is applied to affected part, bactericidal antiphlogistic, treatment scald can be played and cicatrix can be treated.
Detailed description of the invention 2
One antibacterials of the present invention, described antibacterials contain the didecyldimethylammonium ammonia chloride of 0.0218%, and during the preservation of antibacterials, didecyldimethylammonium ammonia chloride can preserve 90 days under the constant temperature of 37 DEG C.The preparation method of these antibacterials be by solution a, solution b and solution c under the constant temperature of 28 DEG C, completely cut off aeroseal gained after 700:800:1 mixes by volume；
Described solution a is that with ozone, distilled water is processed 30h gained solution under the constant temperature of 28 DEG C；Calcium content in pure water should reach country-level level, and in described pure water, calcium content is less than 380mg/L；Water quality good penetrability treated by ozone, it is possible to penetrate into soft tissue, plays more preferable therapeutic effect；
Solution b is that medical glycerol solution a is made the solution that glycerol concentration is 8/1000；
Solution c is the DDAC solution of 0.0218%；The pH value of described solution c is 9.82.Described antibacterials stock solution can add the lecithin of 0.3% as stabilizer.
Preparing this antibacterials by said method, antibacterials contain possibly together with a kind of novel substance in didecyldimethylammonium ammonia chloride, and described antibacterials, and described novel substance is the Organic substance containing aromatic hydrocarbon.
The application in burn and scald, medical and beauty treatment, common surgical procedures and gynecological of the described antibacterials；Specially there is strong pain relieving, itching-relieving action, reduce the misery of burned patient；Mucosa, in the application of Gynecology, can be carried out painless antibacterial by these antibacterials, and antibacterial ability is higher than ethanol, and does not make mucosa injury, non-stimulated.Through Jilin Province, sanitary monitoring and testing work Spot detection draws: described antibacterials stock solution can 100% kill the pathogenic bacterium such as staphylococcus aureus, escherichia coli, Candida albicans；The bactericidal action time is 2min.Described antibacterials stock solution is to vaginal mucosa irritation index less than 1, and it is non-stimulated for stimulating rank.
During use, after the volume ratio of the medicine stock solution of gained with water 1:10000 by volume being mixed, it is applied to affected part, bactericidal antiphlogistic, treatment scald can be played and cicatrix can be treated.
Detailed description of the invention 3
One antibacterials of the present invention, described antibacterials contain the didecyldimethylammonium ammonia chloride of 0.03%, and during the preservation of antibacterials, didecyldimethylammonium ammonia chloride can preserve 90 days under the constant temperature of 37 DEG C.The method is specially solution a, solution b and solution c under the constant temperature of 30 DEG C, completely cuts off aeroseal gained after 700:800:1 mixes by volume；
Solution a is that with ozone, pure water is processed 36h gained solution under the constant temperature of 30 DEG C；Calcium content in pure water should reach country-level level, and in described pure water, calcium content is less than 380mg/L；Water quality good penetrability treated by ozone, it is possible to penetrate into soft tissue, plays more preferable therapeutic effect；
Solution b is that medical glycerol solution a is made the solution that glycerol concentration is 10/1000；
Solution c is the DDAC solution of 0.03%；The pH value of described solution c is 10.5；Antibacterials stock solution can add the lecithin of 0.3% as stabilizer.
Preparing this antibacterials by said method, antibacterials contain possibly together with a kind of novel substance in didecyldimethylammonium ammonia chloride, and described antibacterials, and described novel substance is the Organic substance containing aromatic hydrocarbon.
The application in burn and scald, medical and beauty treatment, common surgical procedures and gynecological of the described antibacterials；Specially there is strong pain relieving, itching-relieving action, reduce the misery of burned patient；Mucosa, in the application of Gynecology, can be carried out painless antibacterial by these antibacterials, and antibacterial ability is higher than ethanol, and does not make mucosa injury, non-stimulated.Through Jilin Province, sanitary monitoring and testing work Spot detection draws: described antibacterials stock solution can 100% kill the pathogenic bacterium such as staphylococcus aureus, escherichia coli, Candida albicans；The bactericidal action time is 2min.Described antibacterials stock solution is to vaginal mucosa irritation index less than 1, and it is non-stimulated for stimulating rank.
During use, after the volume ratio of the medicine stock solution of gained with water 1:10000 by volume being mixed, it is applied to affected part, bactericidal antiphlogistic, treatment scald can be played and cicatrix can be treated.
Claims (7)
1. the preparation method of antibacterials, it is characterised in that: described antibacterials be by solution a, solution b and solution c under the constant temperature of 25 DEG C ~ 30 DEG C, completely cut off aeroseal gained after 700:800:1 mixes by volume；Gained antibacterials are medicine stock solution, use after the volume ratio of the medicine stock solution of gained with water 1:10000 by volume being mixed during use；
Described solution a is that with ozone, pure water is processed 24h ~ 36h gained solution under the constant temperature of 25 DEG C ~ 30 DEG C；In described pure water, calcium content is less than 380mg/L；
Described solution b is that medical glycerol solution a is made the solution that glycerol concentration is 5/1000 ~ 10/1000；
Described solution c is the aqueous solution accounting for the DDAC that described liquor capacity percentage ratio is 0.01% ~ 0.03%；The pH value of described solution c is 9 ~ 10.5.
The preparation method of antibacterials the most according to claim 1, it is characterised in that: described constant temperature is 28 DEG C.
The preparation method of antibacterials the most according to claim 1, it is characterised in that: described solution b is that medical glycerol solution a is made the solution that glycerol concentration is 8/1000.
The preparation method of antibacterials the most according to claim 1, it is characterised in that: described solution c is the aqueous solution accounting for the DDAC that described liquor capacity percentage ratio is 0.0218%.
The preparation method of antibacterials the most according to claim 1, it is characterised in that: the pH value of described solution c is 9.82.
6. antibacterials, it is characterised in that: described antibacterials prepare for using method described in claim 1.
7. antibacterials as claimed in claim 6 are in the application preparing the medicine being used in burn and scald, medical and beauty treatment, common surgical procedures and gynecological.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410385945.XA CN104127396B (en) | 2014-08-07 | A kind of antibacterials and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410385945.XA CN104127396B (en) | 2014-08-07 | A kind of antibacterials and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104127396A CN104127396A (en) | 2014-11-05 |
| CN104127396B true CN104127396B (en) | 2016-11-30 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642449A (en) * | 2009-09-08 | 2010-02-10 | 梁宗贵 | Skin mucous membrane disinfectants and preparation method thereof |
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642449A (en) * | 2009-09-08 | 2010-02-10 | 梁宗贵 | Skin mucous membrane disinfectants and preparation method thereof |
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Effective date of registration: 20170927 Address after: 130021 Jilin province Changchun Chaoyang District Wanbao Street No. 22-3 Patentee after: Kong Lili Address before: Changchun City, Jilin province 130000 city wide Qunying Street Patentee before: Zhang Xiaodong |
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Inventor after: Kong Lili Inventor before: Zhang Xiaodong |
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Effective date of registration: 20180521 Address after: 130000 Qun Ying Street in Changchun City, Jilin Patentee after: Zhang Xiaodong Address before: 130021 Wanbao street, Chaoyang District, Changchun, Jilin Province, No. 22-3 Patentee before: Kong Lili |
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Effective date of registration: 20180608 Address after: 130000 Changchun, Jilin, Jing Yue Development Zone (4666), Vanke Whistler town (phase 1) business 3, business 5, commercial 6 buildings 1 units 202 rooms. Patentee after: Xun Peng Industrial Co., Ltd. Address before: 130000 Qun Ying Street in Changchun City, Jilin Patentee before: Zhang Xiaodong |
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| TR01 | Transfer of patent right |
Effective date of registration: 20190513 Address after: 130000 Changsheng Street Committee 333 Group of Qunying Street, Kuancheng District, Changchun City, Jilin Province Patentee after: Zhang Xiaodong Address before: 130000 Changchun, Jilin, Jing Yue Development Zone (4666), Vanke Whistler town (phase 1) business 3, business 5, commercial 6 buildings 1 units 202 rooms. Patentee before: Xun Peng Industrial Co., Ltd. |