CN104971200A - Tannic acid pH-stable hemorrhoid gel and preparation method thereof - Google Patents
Tannic acid pH-stable hemorrhoid gel and preparation method thereof Download PDFInfo
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- CN104971200A CN104971200A CN201510407761.3A CN201510407761A CN104971200A CN 104971200 A CN104971200 A CN 104971200A CN 201510407761 A CN201510407761 A CN 201510407761A CN 104971200 A CN104971200 A CN 104971200A
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Abstract
The invention discloses a tannic acid pH-stable hemorrhoid gel and a preparation method thereof. The gel is prepared from the following raw materials, by weight: 10-15 parts of tannic acid, 3-6 parts of carbomer, 2-4 parts of polyhexamethylene guanidine, 3-5 parts of lithium magnesium silicate, 2-3 parts of dried alum, 4-6 parts of red halloysite, 1-2 parts of oven subsoil, 3-5 parts of glycerin, 0.5-0.8 part of potassium acid phthalate, 2-3 parts of aloe flower, 3-4 parts of Chinese littleleaf box leaf, 1-2 parts of albizia bark, 3-4 parts of euphorbia hirta, 2-3 parts of sweet potato vine, and a proper amount of deionized water. The tannic acid gel is stable in pH value, wherein the pH value can be kept at 4.5-4.8, and the efficacy of treating and curing hemorrhoid can be greatly developed. In the tannic acid gel, traditional Chinese medicine raw materials of aloe flower, Chinese littleleaf box leaf, and the like are added, match one another, and have the efficacy of dissipating stasis to relieve pain, stopping blood and dispersing swelling, dispelling slough and promoting tissue regeneration, sterilizing and detoxifying the body, killing worm and relieving itching, and the like. According to a synergistic effect of tannic acid and polyhexamethylene guanidine, lithium magnesium silicate, and other traditional Chinese medicine raw materials, the tannic acid gel has an obvious effect on curing hemorrhoid, is short in treatment course and reliable in effect, and has no toxic or side effect.
Description
Technical field
The present invention relates to a kind of tannic acid PH stable type hemorrhoid gel and preparation method thereof, belong to medical art.
Background technology
Hemorrhoid are bottom anal orifice and rectal intestine and the venous plexus generation varicose of anal mucosa and the vein group of the one or more softnesses formed, by directly affecting of anus environment.Anus is owing to containing the very easily water-soluble formation ammonia of ammonia in feces, and ammonia, in alkalescence, also makes the pH value of anus environment also in alkalescence, about PH=8.5.It is PH=4.6 that tannic acid acts on the maximum acid-base value playing convergence healing effect of hemorrhoid, but after common tannic acid ointment (or gel) erasing hemorrhoid in the market, this pH value is affected into alkalescence by anus and feces rapidly, thus loses the effect that hemorrhoid are cured in continuous action convergence.
Summary of the invention
The object of the invention is to for prior art not enough, a kind of tannic acid PH stable type hemorrhoid gel and preparation method thereof is provided, when this gel contacts alkalescence anal tissue and weak base feces, still PH=4.5-4.8 can be maintained, make tannic acid and other raw material synergism, play better convergence and cure hemorrhoid effect.
For achieving the above object, the technical solution used in the present invention is as follows:
Tannic acid PH stable type hemorrhoid gel, is made up of the raw material of following weight portion: tannic acid 10-15 part, carbomer 3-6 part, polyhexamethylene guanidine 2-4 part, lithium magnesium silicate 3-5 part, dried Alumen 2-3 part, Halloysitum Rubrum 4-6 part, humus flava usta 1-2 part, glycerol 3-5 part, Potassium Hydrogen Phthalate 0.5-0.8 part, Flos Aloe 2-3 part, Buxus sinica (Rehd.et Wils.) leaf 3-4 part, Cortex Albiziae 1-2 part, the young careless 3-4 part of breast, Caulis et Folium Ipomoeae 2-3 part, deionized water are appropriate.
The preparation method of tannic acid PH stable type hemorrhoid gel of the present invention, comprises the following steps:
(1) get Flos Aloe, Buxus sinica (Rehd.et Wils.) leaf, Cortex Albiziae, the young grass of breast, Caulis et Folium Ipomoeae mix homogeneously, decoct with water 2 times, doubly, be fried boiling the 8-10 that adds water for the 1st time 1-2h, doubly, be fried boiling the 6-8 that adds water for 2nd time 1-2h, collecting decoction, filter, filtrate is concentrated into the paste that relative density is 1.34-1.38, stand-by;
(2) by tannic acid, dried Alumen, Halloysitum Rubrum, humus flava usta, glycerol mixing, add the deionized water of 1-2 times amount, stir 2-3h, then at 25-30 DEG C of temperature, 24-36h is hatched, add the thick paste that carbomer, polyhexamethylene guanidine, lithium magnesium silicate and step (1) are obtained again, slow stirring 1-2h, viscosity controls within the scope of 55-75Pas;
(3) get Potassium Hydrogen Phthalate and add appropriate deionized water, stir and make the solution that concentration is 10-15%, then use 10% sodium hydroxide solution adjust ph to 4.4;
(4) the O-phthalic potassium hydrogen phthalate ╱ sodium hydroxide test solution buffer of the 3rd step gained is added in the gel of second step gained, slowly stir 1-2h;
(5) sterilizing gets product.
Tannic acid PH stable type hemorrhoid gel of the present invention utilizes tannic acid and other Acid Materials Acidic feature, use O-phthalic potassium hydrogen phthalate ╱ sodium hydroxide test solution buffer, erasing hemorrhoid, when contact alkalescence anal tissue and weak base feces, still the PH=4.5-4.8 of tannic acid PH stable type hemorrhoid gel can be maintained, make tannic acid and other raw material synergism, play better good convergence and cure hemorrhoid effect.
Tannic acid energy precipitating proteins, has astriction, thus protection mucosa, the undue secretion of prevention and hemostasis; Can pain due to hemorrhoid be reduced, reduce hemorrhage, and have the effect preventing bacteriological infection.
Dried Alumen has effect of astringent therapy sore, granulation promoting, hemostasisization corruption;
Halloysitum Rubrum has hemostasis, effect of promoting tissue regeneration and ulcer healing;
Humus flava usta has effect of hemostasia and detumescence;
Polyhexamethylene guanidine has good bactericidal effect, and fungicidal spectrum is wide, and effect is lasting;
Lithium magnesium silicate has good adsorption, the noxious bacteria of adsorbable skin surface, and sterilization and anticorrosion can promote the regeneration of skin;
Carbomer be used as anus bioadhesive polymer, paste on hemorrhoid mucosa, above-mentioned material played a role;
Flos Aloe has effect of the loose poison of blood stasis removing, hemostasis sterilization, anti-inflammatory anti-itch;
Buxus sinica (Rehd.et Wils.) leaf has effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds;
Cortex Albiziae has effect of parasite killing and blood, reducing swelling and alleviating pain;
The young grass of breast has effect of antipyretic antiinflammatory, hemostasis and pain-relieving;
Caulis et Folium Ipomoeae has effect of cooling blood for hemostasis, putrefaction removing evacuation of pus, expelling pus and promoting granulation.
Beneficial effect of the present invention:
Tannic acid gel PH value stabilization of the present invention, in use procedure, pH value can remain between 4.5-4.8 always, and maximum performance receives the effect that tannic acid cures hemorrhoid; The present invention also added the raw material of Chinese medicine such as Flos Aloe, Buxus sinica (Rehd.et Wils.) leaf, and mutual compatibility has the effects such as eliminating stasis to stop pain, hemostasia and detumescence, putrefaction-removing granulation-promoting, disinfecting detoxifying, killing parasites for relieving itching; Tannic acid of the present invention and polyhexamethylene guanidine, lithium magnesium silicate and the mutual synergism of some raw material of Chinese medicine, have significant effect to treatment hemorrhoid, and short treating period, fruit are reliable, and have no side effect, cure rate reaches more than 96%, and effective percentage reaches 100%.
Specific embodiment mode
Embodiment 1
Tannic acid PH stable type hemorrhoid gel, is made up of the raw material of following weight portion: tannic acid 10 parts, carbomer 3 parts, polyhexamethylene guanidine 2 parts, lithium magnesium silicate 3 parts, dried Alumen 2 parts, Halloysitum Rubrum 4 parts, humus flava usta 1 part, glycerol 3 parts, Potassium Hydrogen Phthalate 0.5 part, Flos Aloe 2 parts, 3 parts, Buxus sinica (Rehd.et Wils.) leaf, Cortex Albiziae 1 part, the young grass 3 parts of breast, Caulis et Folium Ipomoeae 2 parts, deionized water are appropriate.
The preparation method of tannic acid PH stable type hemorrhoid gel, comprises the following steps:
(1) get Flos Aloe, Buxus sinica (Rehd.et Wils.) leaf, Cortex Albiziae, the young grass of breast, Caulis et Folium Ipomoeae mix homogeneously, decoct with water 2 times, doubly, be fried boiling the 8-10 that adds water for the 1st time 1-2h, doubly, be fried boiling the 6-8 that adds water for 2nd time 1-2h, collecting decoction, filter, filtrate is concentrated into the paste that relative density is 1.34-1.38, stand-by;
(2) by tannic acid, dried Alumen, Halloysitum Rubrum, humus flava usta, glycerol mixing, add the deionized water of 1-2 times amount, stir 2-3h, then at 25-30 DEG C of temperature, 24-36h is hatched, add the thick paste that carbomer, polyhexamethylene guanidine, lithium magnesium silicate and step (1) are obtained again, slow stirring 1-2h, viscosity controls within the scope of 55-75Pas;
(3) get Potassium Hydrogen Phthalate and add appropriate deionized water, stir and make the solution that concentration is 10-15%, then use 10% sodium hydroxide solution adjust ph to 4.4;
(4) the O-phthalic potassium hydrogen phthalate ╱ sodium hydroxide test solution buffer of the 3rd step gained is added in the gel of second step gained, slowly stir 1-2h;
(5) sterilizing gets product.
Embodiment 2
Tannic acid PH stable type hemorrhoid gel, is made up of the raw material of following weight portion: tannic acid 12 parts, carbomer 5 parts, polyhexamethylene guanidine 3 parts, lithium magnesium silicate 4 parts, dried Alumen 2.5 parts, Halloysitum Rubrum 5 parts, humus flava usta 1.5 parts, glycerol 4 parts, Potassium Hydrogen Phthalate 0.6 part, Flos Aloe 2.5 parts, 3.5 parts, Buxus sinica (Rehd.et Wils.) leaf, Cortex Albiziae 1.5 parts, the young grass 3.5 parts of breast, Caulis et Folium Ipomoeae 2.5 parts, deionized water are appropriate.
Preparation method is with embodiment 1.
Embodiment 3
Tannic acid PH stable type hemorrhoid gel, is made up of the raw material of following weight portion: tannic acid 15 parts, carbomer 6 parts, polyhexamethylene guanidine 4 parts, lithium magnesium silicate 5 parts, dried Alumen 3 parts, Halloysitum Rubrum 6 parts, humus flava usta 2 parts, glycerol 5 parts, Potassium Hydrogen Phthalate 0.8 part, Flos Aloe 3 parts, 4 parts, Buxus sinica (Rehd.et Wils.) leaf, Cortex Albiziae 2 parts, the young grass 4 parts of breast, Caulis et Folium Ipomoeae 3 parts, deionized water are appropriate.
Clinical trial:
Clinical data: 400 routine hemorrhoid patients, are divided into two groups at random, treatment group 200 example, man 112 example, female 88 example, age 18-66 year, average 41.5 years old; Matched group 200 example, man 104 example, female 96 example, year two 19-65 year, average 40.7 years old, two groups of patient's physical data no significant differences (P > 0.05), had comparability.
Therapeutic Method: treat 2 crissum external tannic acid PH of the present invention stable type hemorrhoid gels every day; The common tannic acid gel of matched group 2 crissum externals every day.
Curative effect determinate standard: cure: after treatment, hemorrhoid symptom disappears, and does not recur; Effective: after medication, hemorrhoid symptom alleviates; Invalid: hemorrhoid symptom hemorrhoid symptom indifference front with treatment after treatment, even increase the weight of.
Treatment group patient is after tannic acid PH stable type hemorrhoid gel for treating of the present invention, along with medicine plays a role gradually, have 194 routine patients to cure after medication after January, 6 routine patients are effective, cure rate is 97%, effective percentage reaches 100%, obvious difference before and after after medication, and matched group patient has 113 routine patients to cure at treatments period, 48 routine patients are effective, cure rate is 56.5%, and effective percentage is 80.5%, and the curative effect of tannic acid PH stable type hemorrhoid gel of the present invention is obviously better than common tannic acid gel as can be seen here.Efficacy result is in table 1.
Table 1 tannic acid PH of the present invention stable type hemorrhoid gel is to the therapeutic effect of hemorrhoid
Group | Detection time | Cure number/people | Significant figure/people | Cure rate/% | Effective percentage/% |
Treatment group | After medication January | 194 | 6 | 97 | 100 |
Matched group | After medication January | 113 | 48 | 56.5 | 80.5 |
Claims (2)
1. tannic acid PH stable type hemorrhoid gel, it is characterized in that, be made up of the raw material of following weight portion: tannic acid 10-15 part, carbomer 3-6 part, polyhexamethylene guanidine 2-4 part, lithium magnesium silicate 3-5 part, dried Alumen 2-3 part, Halloysitum Rubrum 4-6 part, humus flava usta 1-2 part, glycerol 3-5 part, Potassium Hydrogen Phthalate 0.5-0.8 part, Flos Aloe 2-3 part, Buxus sinica (Rehd.et Wils.) leaf 3-4 part, Cortex Albiziae 1-2 part, the young careless 3-4 part of breast, Caulis et Folium Ipomoeae 2-3 part, deionized water are appropriate.
2. the preparation method of tannic acid PH stable type hemorrhoid gel as claimed in claim 1, is characterized in that, comprise the following steps:
(1) get Flos Aloe, Buxus sinica (Rehd.et Wils.) leaf, Cortex Albiziae, the young grass of breast, Caulis et Folium Ipomoeae mix homogeneously, decoct with water 2 times, doubly, be fried boiling the 8-10 that adds water for the 1st time 1-2h, doubly, be fried boiling the 6-8 that adds water for 2nd time 1-2h, collecting decoction, filter, filtrate is concentrated into the paste that relative density is 1.34-1.38, stand-by;
(2) by tannic acid, dried Alumen, Halloysitum Rubrum, humus flava usta, glycerol mixing, add the deionized water of 1-2 times amount, stir 2-3h, then at 25-30 DEG C of temperature, 24-36h is hatched, add the thick paste that carbomer, polyhexamethylene guanidine, lithium magnesium silicate and step (1) are obtained again, slow stirring 1-2h, viscosity controls within the scope of 55-75Pas;
(3) get Potassium Hydrogen Phthalate and add appropriate deionized water, stir and make the solution that concentration is 10-15%, then use 10% sodium hydroxide solution adjust ph to 4.4;
(4) the O-phthalic potassium hydrogen phthalate ╱ sodium hydroxide test solution buffer of the 3rd step gained is added in the gel of second step gained, slowly stir 1-2h;
(5) sterilizing gets product.
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Cited By (10)
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WO2023212374A1 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
WO2023212368A1 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Fixative compositions |
WO2023212371A2 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
WO2023212372A1 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
FR3134975A1 (en) | 2022-04-28 | 2023-11-03 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
FR3137570A1 (en) | 2022-07-05 | 2024-01-12 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
FR3137566A1 (en) | 2022-07-05 | 2024-01-12 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
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WO2023212374A1 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
WO2023212368A1 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Fixative compositions |
WO2023212371A2 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
WO2023212372A1 (en) | 2022-04-28 | 2023-11-02 | L'oreal | Compositions suitable as setters |
FR3134975A1 (en) | 2022-04-28 | 2023-11-03 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
WO2023212371A3 (en) * | 2022-04-28 | 2023-12-07 | L'oreal | Cosmetic compositions comprising polyphenols, suitable as setters |
FR3137570A1 (en) | 2022-07-05 | 2024-01-12 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
FR3137566A1 (en) | 2022-07-05 | 2024-01-12 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
FR3137572A1 (en) | 2022-07-05 | 2024-01-12 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
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FR3137565A1 (en) | 2022-07-05 | 2024-01-12 | L'oreal | COMPOSITIONS SUITABLE AS FIXATORS |
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