CN106420815A - Pharmaceutical composition and preparation method and application thereof - Google Patents
Pharmaceutical composition and preparation method and application thereof Download PDFInfo
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- CN106420815A CN106420815A CN201611154166.4A CN201611154166A CN106420815A CN 106420815 A CN106420815 A CN 106420815A CN 201611154166 A CN201611154166 A CN 201611154166A CN 106420815 A CN106420815 A CN 106420815A
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- pharmaceutical composition
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- alumen
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- hydrargyrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/28—Mercury; Compounds thereof
Abstract
The invention provides a pharmaceutical composition, a preparation method and application thereof. The pharmaceutical composition is made of alum, nitrite and mercury, wherein the mass ratio of alum, nitrite and mercury is (0.6 to 1.1) : (0.8 to 1.2): (0.9 to 1.2). The pharmaceutical composition of the present invention is prepared from the above traditional Chinese traditional medicine and is volatilized and purified during the heating process. The pharmaceutical composition can have the hemostasis, anti-inflammatory and swelling eliminating effects in a small amount. In addition, the pharmaceutical composition has a good detoxification effect of drawing out pus, is an important medicine in the surgery department, and is low in usage and used for treating obstruction of pus elimination after ulceration; or slough is not removed, new muscle cannot grow. The pharmaceutical composition can be also used for treating diarrhea caused by canine parvovirus, intestinal ulcers and blood in the stool. The preparation method of the pharmaceutical composition has the advantages of convenience, simplicity and easy operation, and is suitable for mass production and wide application.
Description
Technical field
The present invention relates to medical manufacture field, in particular to a kind of pharmaceutical composition and its preparation method and application.
Background technology
In existing treatment, for hemorrhagic wound, how using cleaning a wound, wrapping up, adjusted by human autoimmune's mechanism
Section is that wound heals automatically.But for autoimmune mechanism regulating power difference other, wound obstinate easily causes more
Serious injury.Can stop blooding or suppress bacteria breed in right amount using wound medicine, such as hemorrhage, antibiotic medicine etc.,
But, in existing medicine, effect is single it is impossible to take into account effect of hemostasis, antiinflammatory and not good to the healing of ulcer surface
Curative effect.
In view of this, the special proposition present invention.
Content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition, to solve existing treatment hemorrhagic or exedens
Wound medicine does not have the double effects of hemostasis and antiinflammatory, and the medicine for external use festering for treat wound, convalescent period length, effect
Slow problem, described pharmaceutical composition, a small amount of use, you can there is hemostasis, antiinflammatory, detumescence, and this medicine is also
There is good drawing out pus by applying a plaster to the affected part corruption evacuation of pus effect, be surgery key medicine, consumption is little, after bursting for carbuncle, pus go out not smooth；Or slough is not
Go, new meat is difficult raw.
The second object of the present invention is to provide a kind of preparation method of described pharmaceutical composition, and raw material is pressed by the method
Ratio mixing, heating, you can obtain this pharmaceutical composition, have the advantages that convenience, simple, easily operated, suitable batch production
Apply with extensive.
In order to realize the above-mentioned purpose of the present invention, spy employs the following technical solutions：
A kind of pharmaceutical composition, is prepared from by Alumen, Sal Nitri and hydrargyrum, wherein, the matter of described Alumen, Sal Nitri and hydrargyrum
Amount ratio is (0.6～1.1)：(0.8～1.2)：(0.9～1.2).
Alumen, is made up of the processed refinement of Sulfateses mineral alunite, the main potassium [KAl (SO of aluminum containing aqueous sulfuric acid4)2·
12H2O].Sour in the mouth, puckery, cold in nature.Return lung, spleen, liver, large intestine channel.External has the effect of removing toxic substances parasite killing, dampness removing to stop itchin；Tool for oral administration
There is hemostasis antidiarrheal, the effect of dispel wind-phlegm.External treatment is used for eczema, scabies, proctoptosis, hemorrhoid, discharging ear；Take orally for chronic diarrhea not
Only, have blood in stool, metrorrhagia, epilepsy is gone mad.Alumen (calcined) has the effect of removing dampness sore, hemostasisization corruption.For eczema eczema, proctoptosis, hemorrhoid,
Discharging ear, pudendal pruritus leukorrhagia, epistaxis bleeding from the gum, polyp.
Sal Nitri, is crystalline solid or the artifact of the processed refining of Nitrateses Sal Nitri race mineral niter.Bitter in the mouth,
Salty, warm in nature.GUIXIN, spleen channel.Have functions that to ward off and dirty wash turbid, removing mass of assaulting fortified position, diuretic removing the relative excess, removing toxic substances and promoting subsidence of swelling.Cure mainly summer-heat day wound cold,
Cold and heat are vomited and diarrhoea, lump in the abdomen lump in the abdomen lump in the abdomen, neck scrofula, abdominal pain due to blood stasis, the black subcutaneous ulcer of jaundice, and sandstone drench pain, headache, sore throat, conjunctival congestion, and skin infection swells
Poison.
Hydrargyrum, Chinese medicine name.For liquid metal hydrargyrum, and containing micro silver, natural mercury ore is not a lot of to be seen, generally system's cinnabar
Ore heating is distilled and is obtained.Acrid in the mouth, cold in nature.GUIXIN, liver and kidney channel.There is sterilization, under rushing down, diuresis, parasite killing, the effect of delousing.Often
For skin scabies, stubborn dermatitis, head louse.
Pharmaceutical composition provided herein, is prepared from by above three taste Chinese medicines, during heating, waves
Send out purification, and generate a small amount of mercury oxide.This medical instrument has good hemostasis, antiinflammatory, bactericidal action, and dissociate the micro mercury ion
Can combine with the sulfydryl in pathogen respiratory enzyme, so that enzyme is lost activity, lead to bacterial death, thus playing bactericidal action. its
Solution all has to bacillus pyocyaneus, beta hemolytic streptococcuss, escherichia coli and staphylococcus aureuses in test tube in various degree
Inhibitory action, to sterilization circle on flat board for the bacillus pyocyaneus.This pharmaceutical composition has good hemostasis, the effect of antiinflammatory,
Also have functions that to search pus, draw out pus by applying a plaster to the affected part, removing the necrotic tissue, granulation promoting.Can be used for treating acute hemorrhagic wound additionally it is possible to be used for control carbuncle,
Furuncle, syphilis, primary sore, all skin infection meat dark violet black, the open sore part is hard, do not close up long.
This pharmaceutical composition not only can stop blooding, antiinflammatory, also has fine effect, three-in-one for exedens wound.Right
Wound of suppurating in festering is extremely effective, can make diminishing inflammation of wound, completely cuts off pathogenic bacteria, the rapid purpose forming a scab, reaching quick healing.And
And, this drug dose is few, first use, you can reach the purpose of healing.External also should not persistently use in a large number, nearly mouth, eye, breast
The positions such as head, Qizhong should not be used；Also should not use when skin ulcer face is excessive, in case accumulating poisoning.Hepatic and kidney function obstacle person, anemia of pregnant woman's disabling.
Preferably, the mass ratio of described Alumen, Sal Nitri and hydrargyrum is (0.8～1.0)：(1.0～1.2)：(0.9～1.0).
The scope of hydrargyrum in the component of this pharmaceutical composition can be optimized.
Preferably, the mass ratio of described Alumen, Sal Nitri and hydrargyrum is (0.9～1.0)：(1.1～1.2)：1.
The component of aforementioned pharmaceutical compositions can be optimized further, be Sal Nitri and Alumen be excessive, slightly larger than water
The usage amount of silver.
Preferably, the dosage form of described medicine is powder, unguentum, water preparation, tincture, granule or capsule.
Powder has dry, protection and thermolysis.It is mainly used in the skin lesion, particularly suitable that acute dermatitises are no rotten to the corn and ooze out
Wipe position in.Conventional has Pulvis Talci, oxide powder and zinc, calamine stone etc..
Unguentum part ointment and plaster, are as substrate with vaseline, simple Ointment (vegetable oil adds Cera Flava) or Animal fat etc.
Dosage form.There is protection wound surface, prevent dry and cracked effect, ointment permeability compared with Emulsion more preferably, wherein adds different pharmaceutical can send out
Wave different therapeutical effect, be mainly used in the diseases such as chronic eczema, lichen chronicus simplex, because ointment can stop moisture evaporation,
Be unfavorable for radiate, therefore should not be used in acute dermatitises, eczema ooze out phase etc..
Plaster is attached at by the semisolid matrix that soap, rubber, resin etc. form and mounts on material (as cloth, paper
Material or apertured plastic films).Plaster can be firmly stuck to skin surface, persistent, can stop moisture loss, softening skin
With the effect strengthening drug permeability.Conventional has zinc oxide plaster, the peaceful plaster of skin disease, stripping first plaster etc..
Water preparation is the aqueous solution of medicine.There is cleaning, astriction, be mainly used in soak.Soak has mitigation congestion and edema
Act on removing secretions and crust etc., such as also can play antibacterial, antiinflammation containing antibacterials in solution, be mainly used in urgency
Property dermatitis and eczema class disease.
Tincture is that the ethanol of medicine normal concentration leaches or dissolves the supernatant liquid preparation made it is also possible to use fluid extract
Dilution is made.Divide for oral administration and two kinds of external.Tincture preparation need not be heated, and composition is purer, and active constituent content is high, and dosage is accurate
Really, absorb rapidly, be suitable for preparing the preparation containing volatile ingredient or thermo-labile component.Preferably, the tincture of the present invention is
Tincture for oral administration.
Granule and capsule can directly carry out enteral administration.
Preferably, described unguentum also includes vaseline, and described vaseline is (120 with the mass ratio of described pharmaceutical composition
～200)：1.
The ratio of vaseline is much larger than the content of pharmaceutical composition, can reduce side effect, improves the moist degree of medicine.
The preparation method of pharmaceutical composition as above, comprises the following steps：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed
On Sal Nitri and Alumen, sealing container post-heating, can obtain this pharmaceutical composition in container top after heating.
The application provides a kind of preparation method of described pharmaceutical composition, and raw material is mixed in proportion, heats by the method,
This pharmaceutical composition can be obtained, there is convenience, simple, easily operated, suitable batch production and extensively application.
Preferably, the process of described heating, specifically includes following steps：
First slow fire heats 50～60 minutes, then moderate heat heats 50～60 minutes, and last intense fire heats 50～60 minutes.
Preferably, the temperature of described slow fire is 120～150 DEG C, and the temperature of described moderate heat is 150～180 DEG C, described intense fire
Temperature be 180～200 DEG C.
In the manufacture field of Chinese medicine, it is conventional term for slow fire, moderate heat and intense fire, and also has certain temperature model
Enclose.
Application in the wound medicament of preparation human or animal for the pharmaceutical composition as above.
Application in the intestinal medication of the gastroenteropathy in preparation animal for the pharmaceutical composition as above, preferably described
Pharmaceutical composition preparation dog class Canine Parvovirus intestinal medication in application.
Canine Parvovirus, belong to Parvoviridae, and parvovirus belong to., after digestive tract infection virus, virus is main for healthy dogs
Attack two kinds of cells, one kind is enterocyte, and one kind is myocardial cell, respectively performance gastrointestinal symptom and myocarditiss symptom,
Myocarditiss are common with pup.Canine Parvovirus main infection dog, especially pup, infectiousness is extremely strong, and mortality rate is also high.Enteritis disease dog
Initial stage spirit is depressed, anorexia, accidental heating, soft stool or slightly vomiting, subsequently develops into frequent vomiting and acutely diarrhoea.Originally
Feces gray, yellow or milky, carry g., jelly-like mucus, discharge thereafter soy sauce sample or the Fructus Lycopersici esculenti juice sample hemafecia of stench.Sick dog
Rapid dehydration, becomes thin, and proscopiny is in disorder by hair, and skin is nonelastic, ear nose, coolness of extremities, and spirit is highly depressed, shock, extremely
Die.From the first symptom of disease slightly to being seriously usually no more than 2 days, the whole course of disease is usually no more than one week.
The application can be festered for the intestines that Canine Parvovirus cause and be played good Healing, alleviating diarrhoea and disease
The infection further of poison, then coordinate viral therapy, effectively cure dog class, reduce mortality rate.
Compared with prior art, beneficial effects of the present invention are：
(1) pharmaceutical composition provided herein, is prepared from by above three taste Chinese medicines, in the process of heating
In, volatilization purification, and generate a small amount of mercury oxide, there is good hemostasis, antiinflammatory, bactericidal action, also have search pus, draw out pus by applying a plaster to the affected part,
Removing the necrotic tissue, effect of granulation promoting.Can be used for treating acute hemorrhagic wound additionally it is possible to be used for control carbuncle, furuncle, syphilis, primary sore, one
Cut skin infection meat dark violet black, the open sore part is hard, do not close up long.
(2), pharmaceutical composition provided herein wound of suppurating particularly with festering is extremely effective, and wound can be made to disappear
Inflammation, completely cuts off pathogenic bacteria, the rapid purpose forming a scab, reaching quick healing, suppurating not only for wound has effect, for intestines ulcer,
Fester also effective in cure, the intestines especially Canine Parvovirus of dog class being caused is festered and had good curative effect.
(3) pharmaceutical composition provided herein, medicine stability is good, is not easily decomposed, and this drug dose is few, once makes
With, you can reach the purpose of healing.
(4) the application provides a kind of preparation method of described pharmaceutical composition, raw material is mixed in proportion, heats, that is,
This pharmaceutical composition can be obtained, there is convenience, simple, easily operated, suitable batch production and extensively application.
Specific embodiment
Below in conjunction with specific embodiment, technical scheme is clearly and completely described, but ability
Field technique personnel will be understood that, following described embodiment is a part of embodiment of the present invention, rather than whole embodiments,
It is merely to illustrate the present invention, and be not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of not making creative work, broadly falls into the model of present invention protection
Enclose.Unreceipted actual conditions person in embodiment, the condition according to normal condition or manufacturer's suggestion is carried out.Agents useful for same or instrument
Unreceipted production firm person, being can be by the commercially available conventional products bought and obtain.
Embodiment 1
The pharmaceutical composition that the present embodiment is provided, is prepared from by following component：
Alumen 6g, Sal Nitri 8g and hydrargyrum 9g.
The preparation method of this pharmaceutical composition, specifically includes following steps：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed
On Sal Nitri and Alumen, after sealing container, first slow fire heats 60 minutes, then moderate heat heats 60 minutes, and last intense fire heats 60 minutes,
This pharmaceutical composition can be obtained in container top after heating；
Wherein, the temperature of slow fire is 120～150 DEG C, and the temperature of moderate heat is 150～180 DEG C, the temperature of intense fire is 180～
200℃.
Embodiment 2
The pharmaceutical composition that the present embodiment is provided, is prepared from by following component：
Alumen 10g, Sal Nitri 12g and hydrargyrum 12g.
The preparation method of this pharmaceutical composition, specifically includes following steps：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed
On Sal Nitri and Alumen, after sealing container, first slow fire heats 60 minutes, then moderate heat heats 60 minutes, intense fire heating 60 minutes, finally
Slow fire heats 60 minutes, can obtain this pharmaceutical composition in container top after heating；
Wherein, the temperature of slow fire is 120～150 DEG C, and the temperature of moderate heat is 150～180 DEG C, the temperature of intense fire is 180～
200℃.
Embodiment 3
The pharmaceutical composition that the present embodiment is provided, is prepared from by following component：
Alumen 8g, Sal Nitri 10g and hydrargyrum 9g.
The preparation method of this pharmaceutical composition, specifically includes following steps：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed fire
On nitre and Alumen, after sealing container, first slow fire heats 50 minutes, then moderate heat heats 60 minutes, and last intense fire heats 60 minutes, plus
This pharmaceutical composition can be obtained in container top after heat；
Wherein, the temperature of slow fire is 120～150 DEG C, and the temperature of moderate heat is 150～180 DEG C, the temperature of intense fire is 180～
200℃.
Embodiment 4
The pharmaceutical composition that the present embodiment is provided, is prepared from by following component：
Alumen 11g, Sal Nitri 12g and hydrargyrum 10g.
The preparation method of this pharmaceutical composition, specifically includes following steps：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed
On Sal Nitri and Alumen, after sealing container, first slow fire heats 60 minutes, then moderate heat heats 50 minutes, and last intense fire heats 60 minutes,
This pharmaceutical composition can be obtained in container top after heating, and this pharmaceutical composition is prepared into capsule；
Wherein, the temperature of slow fire is 120～150 DEG C, and the temperature of moderate heat is 150～180 DEG C, the temperature of intense fire is 180～
200℃.
Embodiment 5
The pharmaceutical composition that the present embodiment is provided, is prepared from by following component：
Alumen 10g, Sal Nitri 12g and hydrargyrum 10g.
The preparation method of this pharmaceutical composition, specifically includes following steps：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed
On Sal Nitri and Alumen, after sealing container, first slow fire heats 60 minutes, then moderate heat heats 50 minutes, and last intense fire heats 50 minutes,
Go heat after container top 10 powder, add 1000g vaseline be mixed and made into ointment, you can obtain this drug regimen
Thing；
Wherein, the temperature of slow fire is 120～150 DEG C, and the temperature of moderate heat is 150～180 DEG C, the temperature of intense fire is 180～
200℃.
Experimental example 1 case
Case 1 Xu certain, 29 years old, by shell scratch instep when by the sea, after cleaning a wound, spill thin in wound surface
The pharmaceutical composition that thin one layer of the embodiment of the present application 1 is provided, rapid hemostasis, and carry out suitable wrapping with gauze, second day
Wound healing and no any inflammation infection phenomenons.
Case 2 Korea Spro, 45 years old, be a country sport fan, in hill climbing process, arm injury, do not obtain and
When sterilization, simply simply wrap up.After going down the hill, discovery wound is suppurated, disunion.After cleaning a wound, using a small amount of basis
The application pharmaceutical composition that provided of embodiment 2, be uniformly distributed with wound at gauze wrapping, pull down gauze, wound two days later
Healing incrustation.
Case 3 beam, 6 years old, after breaking knee, due to often perspiring and contacting water so that wound does not heal well.
After cleaning a wound, the pharmaceutical composition that provided using a small amount of the embodiment of the present application 1, be uniformly distributed with wound at use gauze
Wrapping, pulls down gauze for second day, and wound healing is formed a scab.
Case 4 Cibotium barometz (L.) J. Sm., 2 years old, is scratched by sharp objects, through shaving with after cleaning a wound, real using a small amount of the application
Apply the pharmaceutical composition that example 3 is provided, be uniformly distributed with wound at gauze wrapping, stop blooding immediately.Gauze is pulled down, wound after one day
Mouth healing incrustation, no infection and inflammation phenomenon.
The diarrhea treatment that experimental example 2 pharmaceutical composition provided herein causes to Canine Parvovirus
The medicine being provided using the embodiment of the present application 4, pet clinic of Beijing is sought medical advice to December in January, 2015 or
The dog class of the infection Canine Parvovirus of relief is treated, and once, severe patient adds once intestinal canal administration for second day.Amount to 45
Different types of dog, wherein male dogs 25, male and female dog 20.In age distribution, the young dog of 1～6 month 43,1～6
The above the average age for marriage dog 2 of the moon.
Treatment standard is as follows：
Effectively stop diarrhoea for dog class and have blood in stool, but if Canine parvovirus infection myocardial cell, then cannot cure.
Cure and stop diarrhoea for dog class and have blood in stool, after carrying out antiviral therapy, get well.
Invalid still have blood in stool for dog class or suffer from diarrhoea, until dead.
Experiment statisticses result is as shown in table 1.
The result statistics of the diarrhoea that Canine Parvovirus cause treated by table 1
Test result indicate that, pharmaceutical composition provided herein, can be with effectively treatment because Canine Parvovirus cause
Diarrhoea, have blood in stool, effective percentage reaches 100%, and cure rate reaches 91.1%.
In sum, pharmaceutical composition provided herein, is prepared from by above three taste Chinese medicines, in heating
During, volatilization purification, and generate a small amount of mercury oxide, there is good hemostasis, antiinflammatory, bactericidal action, also have and search pus, pull out
Poison, removing the necrotic tissue, effect of granulation promoting.Can be used for treating acute hemorrhagic wound additionally it is possible to be used for control carbuncle, furuncle, syphilis, under
Infantile malnutrition, all skin infection meat dark violet black, the open sore part is hard, do not close up long.This pharmaceutical composition wound of suppurating particularly with festering extremely has
Effect, can make diminishing inflammation of wound, completely cut off pathogenic bacteria, the rapid purpose forming a scab, reaching quick healing, and suppurating not only for wound has work
With for intestines ulcer, festering also effective in cure, the intestines that especially Canine Parvovirus of dog class caused is festered good treatment
Effect.The preparation method of described pharmaceutical composition, raw material is mixed in proportion, heats, you can obtain this pharmaceutical composition, the side of having
Just, simple, easily operated the advantages of, it is suitable for batch production and extensive application.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that various embodiments above is only used
So that technical scheme to be described, it is not intended to limit；It will be understood by those within the art that：Without departing substantially from this
In the case of bright spirit and scope, the technical scheme described in foregoing embodiments can be modified, or to wherein
Some or all of technical characteristic carries out equivalent；And these modifications or replacement, do not make the essence of appropriate technical solution
Depart from the scope of various embodiments of the present invention technical scheme；It is, therefore, intended that including in the following claims belonging to the present invention
In the range of all these substitutions and modifications.
Claims (10)
1. a kind of pharmaceutical composition is it is characterised in that be prepared from by Alumen, Sal Nitri and hydrargyrum, wherein, described Alumen, Sal Nitri
Mass ratio with hydrargyrum is (0.6～1.1)：(0.8～1.2)：(0.9～1.2).
2. pharmaceutical composition according to claim 1 is it is characterised in that the mass ratio of described Alumen, Sal Nitri and hydrargyrum is
(0.8～1.0)：(1.0～1.2)：(0.9～1.0).
3. pharmaceutical composition according to claim 1 is it is characterised in that the mass ratio of described Alumen, Sal Nitri and hydrargyrum is
(0.9～1.0)：(1.1～1.2)：1.
4. the pharmaceutical composition according to any one of claim 1-3 it is characterised in that described medicine dosage form be powder,
Unguentum, water preparation, tincture, granule and capsule.
5. pharmaceutical composition according to claim 4 is it is characterised in that described unguentum also includes vaseline, described all scholars
Woods is (120～200) with the mass ratio of described pharmaceutical composition：1.
6. the preparation method of the pharmaceutical composition according to any one of claim 1-5 is it is characterised in that include following walking
Suddenly：
By Sal Nitri and Alumen mix homogeneously, it is placed in a container that can seal, hydrargyrum is placed on mixed Sal Nitri
On Alumen, sealing container post-heating, can obtain this pharmaceutical composition in container top after heating.
7. the preparation method of pharmaceutical composition according to claim 6 is it is characterised in that the process of described heating, specifically
Comprise the following steps：
First slow fire heats 50～60 minutes, then moderate heat heats 50～60 minutes, and last intense fire heats 50～60 minutes.
8. the preparation method of pharmaceutical composition according to claim 7 is it is characterised in that the temperature of described slow fire is 120
～150 DEG C, the temperature of described moderate heat is 150～180 DEG C, and the temperature of described intense fire is 180～200 DEG C.
9. application in the wound medicament of preparation human or animal for the pharmaceutical composition according to any one of claim 1-5.
10. in the intestinal medication of the gastroenteropathy in preparation animal for the pharmaceutical composition according to any one of claim 1-5
Application, the application in the intestinal medication of the preferably described pharmaceutical composition Canine Parvovirus in preparation dog class.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611154166.4A CN106420815A (en) | 2016-12-14 | 2016-12-14 | Pharmaceutical composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611154166.4A CN106420815A (en) | 2016-12-14 | 2016-12-14 | Pharmaceutical composition and preparation method and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106420815A true CN106420815A (en) | 2017-02-22 |
Family
ID=58216618
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611154166.4A Pending CN106420815A (en) | 2016-12-14 | 2016-12-14 | Pharmaceutical composition and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350377A (en) * | 2021-07-16 | 2021-09-07 | 高庆德 | Composition for removing necrotic tissue and promoting tissue regeneration, preparation method and application thereof |
-
2016
- 2016-12-14 CN CN201611154166.4A patent/CN106420815A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 闵捷等: "《毒性中药的临床应用》", 30 April 1994, 中国中医药出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350377A (en) * | 2021-07-16 | 2021-09-07 | 高庆德 | Composition for removing necrotic tissue and promoting tissue regeneration, preparation method and application thereof |
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Application publication date: 20170222 |