CN114452319A - A Chinese medicinal gel for preventing and treating mosquito bite, and its preparation method - Google Patents
A Chinese medicinal gel for preventing and treating mosquito bite, and its preparation method Download PDFInfo
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- CN114452319A CN114452319A CN202210225730.6A CN202210225730A CN114452319A CN 114452319 A CN114452319 A CN 114452319A CN 202210225730 A CN202210225730 A CN 202210225730A CN 114452319 A CN114452319 A CN 114452319A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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Abstract
The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine gel for preventing and treating mosquito bites and a preparation method thereof, the traditional Chinese medicine gel for preventing and treating mosquito bites consists of a traditional Chinese medicine extraction composition and a gel matrix, wherein the traditional Chinese medicine extraction composition is prepared from clove oil, cinnamon oil, eucalyptus oil, camphor, methyl salicylate, menthol and peppermint oil according to a certain weight part ratio; the traditional Chinese medicine gel for preventing and treating mosquito bites also has good disinfection effect on symptoms caused by bites of malignant poisonous organisms such as poisonous bees, poisonous snakes, scorpions and the like with certain toxicity; in addition, the traditional Chinese medicine gel for preventing and treating mosquito bites also has good prevention effect on mosquito bites.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine gel for preventing and treating mosquito bites and a preparation method thereof.
Background
The skin is bitten by mosquitoes to cause a strong uncomfortable feeling of a human body, for example, the mosquitoes stab the skin through the mouth organ, saliva or venom injected into the skin generates allergic reaction to cause inflammation after entering the skin of the human body, and symptoms such as swelling, rash, pruritus and the like can appear; the contact of caterpillars with the skin also causes itching, swelling, pain, etc. Symptoms caused by mosquito bites are not treated timely, discomfort can exist for a long time, normal life is affected, skin breakage caused by scratching can be caused in some cases, attractiveness is affected, and local inflammation diffusion can be caused.
At present, common liniments such as iodine tincture, essential balm, cooling oil and floral water are generally used for treating mosquito bites, although the common liniments can relieve local pain, the effects are not ideal, especially the purposes of quickly relieving itching, relieving pain and diminishing swelling are difficult to achieve, especially biting of some poisonous insects which are more serious than mosquitoes, such as venomous snake bites, scorpion bites, caterpillar bites and the like, almost do not work, and therefore, a preparation capable of effectively treating the mosquito bites is needed to be provided.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine gel for preventing and treating mosquito bites and a preparation method thereof, and solves the technical problems that in the prior art, a common liniment for mosquito bites is not ideal in use effect and cannot rapidly relieve itching, pain and swelling.
To solve the above technical problem, a first aspect of the present invention is:
the traditional Chinese medicine gel for preventing and treating mosquito bites is composed of a traditional Chinese medicine extract composition and a gel matrix, wherein the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 1-10 parts of clove oil, 1-10 parts of cinnamon oil, 1-20 parts of eucalyptus oil, 1-20 parts of camphor, 1-20 parts of methyl salicylate, 10-40 parts of menthol and 10-40 parts of peppermint oil.
Preferably, the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 3-8 parts of clove oil, 3-8 parts of cinnamon oil, 5-15 parts of eucalyptus oil, 5-15 parts of camphor, 5-15 parts of methyl salicylate, 15-35 parts of menthol and 15-35 parts of peppermint oil.
Preferably, the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 5 parts of clove oil, 5 parts of cinnamon oil, 10 parts of eucalyptus oil, 10 parts of camphor, 10 parts of methyl salicylate, 25 parts of menthol and 25 parts of peppermint oil.
Preferably, the menthol adopts pharmaceutic adjuvant menthol produced by Anhui Huaxin biotechnology limited; the peppermint oil is medicinal adjuvant peppermint oil with purity of 78% produced by Anhui Huaxin Biotechnology limited.
Preferably, the clove oil, the cinnamon oil and the eucalyptus oil are all prepared by Anhui Huaxin Biotechnology limited.
Preferably, the clove oil is high-purity clove oil.
The second aspect of the present invention is:
the invention provides a preparation method of a traditional Chinese medicine gel for preventing and treating mosquito bites, which comprises the following steps:
(1) sequentially adding oleum Caryophylli, oleum Cinnamomi, oleum Eucalypti, Camphora, and methyl salicylate into oleum Menthae Dementholatum;
(2) mixing the mixture obtained in the step (1), and filtering to remove residues;
(3) adding menthol into the mixture treated in the step (2), and fully stirring and uniformly mixing;
(4) adding appropriate amount of gel matrix, stirring, and mixing to obtain Chinese medicinal gel.
Preferably, the gel matrix in the step (4) is prepared by:
(4.1) uniformly mixing a proper amount of carbomer, glycerol and water;
(4.2) adding dilute hydrochloric acid to adjust the pH value;
and (4.3) slightly draining the alkali liquor to the mixture prepared in the step (4.2), and slowly stirring until a bubble-free and ultra-fine gel matrix is formed.
Preferably, the weight parts of the components in the step (1) and the step (3) are as follows: 5 parts of clove oil, 5 parts of cinnamon oil, 10 parts of eucalyptus oil, 10 parts of camphor, 10 parts of methyl salicylate, 25 parts of menthol and 25 parts of peppermint oil.
Preferably, the menthol adopts pharmaceutic adjuvant menthol produced by Anhui Huaxin biotechnology limited; the peppermint oil is medicinal adjuvant peppermint oil with purity of 78% produced by Anhui Huaxin Biotechnology limited.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine gel for preventing and treating mosquito bites consists of a traditional Chinese medicine extract composition and a gel matrix, wherein the traditional Chinese medicine extract composition is prepared from clove oil, cinnamon oil, eucalyptus oil, camphor, methyl salicylate, menthol and peppermint oil according to a certain weight part ratio, and the traditional Chinese medicine gel for preventing and treating mosquito bites has a quick and effective eliminating effect on swelling, rash, pruritus and other symptoms caused by biting or contact of mosquitoes, caterpillars and the like.
2. The Chinese medicinal gel for preventing and treating mosquito bite also has good effect of eliminating symptoms caused by biting of malignant poisonous organisms such as poisonous bees, poisonous snakes, scorpions and the like with certain toxicity.
3. The traditional Chinese medicine gel for preventing and treating mosquito bites has good prevention effect on mosquito bites.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The pharmacological analysis of the traditional Chinese medicine gel for preventing and treating mosquito bites comprises the following steps:
clove oil: salty, pungent, warm and toxic, entering liver, spleen and lung meridians; warming stomach, lowering adverse qi, warming kidney, and relieving pain; can be used for treating stomach cold, distending pain, singultus, vomiting, diarrhea, hernia pain, arthralgia, toothache, and halitosis. Compendium supplement: "sweet and pungent flavor, strong heat in property". "; examination of drug Properties: to strengthen yang and to suck kidney, it is indicated for hernia with cold yin. "; wang Xiang (pharmaceutical science): "used for gastrointestinal hyperactive qi, colic, dyspepsia, nausea and emesis; rheumatalgia, neuralgia and toothache. ".
Cinnamon oil: slightly cold in nature, bitter in taste, slightly toxic, pungent, sweet and hot; entering kidney, spleen, heart and liver meridians; tonify fire and strengthen yang, dispel cold to alleviate pain, warm meridians and unblock collaterals. Mainly treats the symptoms of kidney yang deficiency, decline of vital gate fire, intolerance of cold, cold limbs, soreness and weakness of waist and knees, impotence, spermatorrhea, difficult urination or frequent micturition, shortness of breath, dyspnea and tachypnea, edema and oliguria; decline of vital gate fire, failure of fire to return to its source, wearing yang, checking yang, and upper heat and lower cold, flushed face and cold feet, dizziness and tinnitus, and broken mouth and tongue; deficiency-type cold of spleen and kidney, abdominal cold pain, impaired appetite and loose stool; kidney-deficiency lumbago; cold-dampness arthralgia; cold hernia pain; infertility due to cold womb, dysmenorrhea, amenorrhea, postpartum blood stasis abdominal pain; abscess due to yin-abscess with multiple abscess or deficiency-type cold abscess without ulceration or astringing after ulceration. The book Jing: pungent and warm in flavor. "; the bibliography: sweet and pungent in flavor and big heat. Has little toxicity. "; treatise on herb Property: bitter and pungent taste, and no toxicity. "; lei Gong processing pharmacology explanation: enter heart, spleen, lung and kidney meridians. "; ben Cao Jing Shu (the book of materia Medica Prime and Dredging): the cassia bark core enters the shaoyin and the jueyin meridian blood system. The cinnamon bark enters the blood system of foot shaoyin and jueyin meridians. "; the book on the incised usage of drug property: enter liver, kidney and gate of life blood. ".
Eucalyptus oil: pungent, bitter and cold. It enters lung, stomach, spleen and liver meridians. Dispelling wind, relieving exterior syndrome, clearing away heat and toxic materials, killing parasites, and relieving itching. Can be used for treating common cold, hyperpyrexia, headache, cough with asthma due to lung heat, pertussis, abdominal distention and pain, diarrhea, dysentery, filariasis, malaria, rheumatalgia, carbuncle, sore, toxic swelling, eczema, scabies, burn, scald, and traumatic hemorrhage. Antibacterial action volatile oil has inhibitory action against Bacillus subtilis and Staphylococcus aureus, but has poor effect against Escherichia coli. The cineole contained in the volatile oil has strong antibacterial activity. Guangxi Zhi TCM (TCM treatise on Guangxi): bitter taste, fragrant smell and warm nature. Dispel phlegm, induce blood stasis, resist malaria. The decoction is taken orally for treating dysentery. "; the "Sichuan Chinese materia medica" (1960 edition: it has antipyretic and analgesic effects, and can be used for treating arthralgia. Is nontoxic. It should be used with cautions for those with deficiency-cold constitution. "; the treatise on the national medicine: treat enteritis and bladder diseases. It is also a skin irritant, and can be used for treating neuralgia and rheumatalgia. "; modern practical traditional Chinese medicine: invigorating stomach, expelling pathogenic wind. "; yunnan Chinese herbal medicine: treat scabies. "; taiwan medical plant journal: the leaf or oil can be used for treating common cold, putrefactive bronchitis, pertussis, malaria, pulmonary gangrene, etc., and also has effects on diabetes and nephritis. "; it is contraindicated: the dosage should not be too large for oral administration, so it should be used with cautions for pregnant women and patients with gastric and duodenal ulcer.
Camphor: pungent, cold and toxic in nature; induce diuresis to alleviate edema, clear heat and remove toxicity. It can be used for treating edema, tympanites, stranguria, whitish and turbid urine, carbuncle, swelling, and skin ulcer. Preparation of raw herb Property: sour and pungent in flavor, cold in nature and with strong toxicity. For edema, abscess, swelling and sore, fetal loss, parasites killing. "; lingnan herbal medicine collection book: pungent, mild in nature and toxic in flavor. Move water, dredge intestines, fall fetus, facilitate urination and defecation, and treat ten kinds of water diseases. "; guangxi materia Medica selection in Guangxi: sour and pungent in flavor, slightly cold in nature and slightly toxic. "; guangdong Chinese medicine: it is indicated for whooping cough and pricking pain in urination. "; yunnan Chinese herbal medicine: ' Xiaoyan Lishui ', dispel the swelling '. Can be used for treating otitis media, cystitis, dysuresia, ascites due to liver cirrhosis, traumatic injury, sprain, and traumatic infection. "; the simple compilation of national drugs in Guangxi: it is indicated for stomach qi pain, impotence, dysentery and fracture. ". It is contraindicated for pregnant women and those with spleen and stomach deficiency, and should not be overdosed or fresh.
Menthol: pungent and cool; dispel wind, clear heat. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, sore throat, toothache, and skin pruritus.
Peppermint oil: pungent, cool and non-toxic. Dispel wind, clear heat. It can be used for treating wind-heat common cold, headache, conjunctival congestion, pharyngalgia, toothache, and skin wind. Chongqingtang (Chongqingtang along with pen): "suffer from wind-heat headache and limit pain", apply on affected part. "; chinese medical dictionary: clearing heat and dispelling wind. It is indicated for headache, conjunctival congestion, pharyngalgia, toothache and wind-heat of skin. "; pharmacology of national drugs: headache, greenish boat, regurgitation, flatulence, etc., and can be administered orally or topically. ".
Methyl salicylate: has the effects of relieving pain, astringing, dredging channels, dispelling pathogenic wind, promoting urination, exciting, etc., and can be used for treating headache, abdominal pain, arthralgia, inflammation, rheumatism, pharyngalgia, dermatoses, and odontopathy, with slight adverse side effect.
The following examples were conducted under the conventional conditions or conditions recommended by the manufacturer, and the reagents or instruments used therefor were conventional products available from commercial suppliers, and 1 part in the following examples was 1 g.
Example 1
A traditional Chinese medicine gel for preventing and treating mosquito bites comprises a traditional Chinese medicine extract composition and a gel matrix, wherein the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 1 part of clove oil, 1 part of cinnamon oil, 1 part of eucalyptus oil, 1 part of camphor, 1 part of methyl salicylate, 10 parts of menthol and 10 parts of peppermint oil.
The gel matrix is prepared by mixing carbomer, glycerol and water, adjusting pH value and removing bubbles.
The preparation method of the traditional Chinese medicine gel for preventing and treating mosquito bites specifically comprises the following steps:
(1) sequentially adding oleum Caryophylli, oleum Cinnamomi, oleum Eucalypti, Camphora, and methyl salicylate into oleum Menthae Dementholatum;
(2) mixing the mixture obtained in the step (1), and filtering to remove residues;
(3) adding menthol into the mixture treated in the step (2), and fully stirring and uniformly mixing;
(4) based on the components of the Chinese medicinal extract composition, adding appropriate amount of gel matrix, and stirring to obtain Chinese medicinal gel.
Here, the gel matrix in step (4) is prepared in a manner that:
(4.1) uniformly mixing a proper amount of carbomer, glycerol and water;
(4.2) adding dilute hydrochloric acid to adjust the pH value;
and (4.3) slightly draining the alkali liquor to the mixture prepared in the step (4.2), and slowly stirring until a bubble-free and ultra-fine gel matrix is formed.
In addition, in this embodiment, the menthol is the pharmaceutical adjuvant menthol produced by anhui huaxin biotechnology limited; the oleum Menthae Dementholatum is 78% medicinal adjuvants oleum Menthae Dementholatum produced by Anhui Huaxin Biotechnology Limited.
The volatile oil alcohols such as clove oil, cinnamon oil, eucalyptus oil and the like used in the examples are all produced by Anhui Huaxin Biotech limited.
The clove oil is high-purity clove oil produced by Anhui Huaxin biotechnology limited, the high-purity clove oil has more excellent pharmacological action compared with common clove oil, and particularly when the high-purity clove oil is mixed with cinnamon oil, eucalyptus oil, camphor, methyl salicylate, menthol and peppermint oil for use, the high-purity clove oil expresses excellent permeability, strongly promotes blood circulation, relieves pain, enhances blood circulation, is cool and itching-relieving, enables skin and muscle to be smooth, and enables the traditional Chinese medicine gel to achieve excellent effects of relieving pain and itching, and diminishing swelling and dispelling toxin.
Example 2
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 3 parts of clove oil, 3 parts of cinnamon oil, 3 parts of eucalyptus oil, 3 parts of camphor, 3 parts of methyl salicylate, 20 parts of menthol and 20 parts of peppermint oil.
Example 3
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 6 parts of clove oil, 6 parts of cinnamon oil, 6 parts of eucalyptus oil, 6 parts of camphor, 6 parts of methyl salicylate, 20 parts of menthol and 20 parts of peppermint oil.
Example 4
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 3 parts of clove oil, 3 parts of cinnamon oil, 9 parts of eucalyptus oil, 7 parts of camphor, 7 parts of methyl salicylate, 20 parts of menthol and 20 parts of peppermint oil.
Example 5
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 3 parts of clove oil, 3 parts of cinnamon oil, 10 parts of eucalyptus oil, 7 parts of camphor, 7 parts of methyl salicylate, 20 parts of menthol and 20 parts of peppermint oil.
Example 6
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 3 parts of clove oil, 3 parts of cinnamon oil, 10 parts of eucalyptus oil, 7 parts of camphor, 7 parts of methyl salicylate, 20 parts of menthol and 20 parts of peppermint oil.
Example 7
The preparation method of the traditional Chinese medicine gel for preventing and treating mosquito bites is the same as that of the embodiment 1, and the difference is that in the embodiment, the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 10 parts of clove oil, 10 parts of cinnamon oil, 20 parts of eucalyptus oil, 20 parts of camphor, 20 parts of methyl salicylate, 40 parts of menthol and 40 parts of peppermint oil.
Example 8
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 5 parts of clove oil, 5 parts of cinnamon oil, 10 parts of eucalyptus oil, 10 parts of camphor, 10 parts of methyl salicylate, 25 parts of menthol and 25 parts of peppermint oil.
Comparative example
The traditional Chinese medicine gel for preventing and treating mosquito bites has the same preparation method as that of the traditional Chinese medicine gel for preventing and treating mosquito bites in the embodiment 1, and is characterized in that the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 5 parts of clove oil, 5 parts of cinnamon oil, 10 parts of eucalyptus oil, 10 parts of camphor, 10 parts of methyl salicylate, 25 parts of menthol and 25 parts of peppermint oil. In the comparison example, common clove oil, cinnamon oil and eucalyptus oil on the market are adopted, common menthol on the market is adopted as the menthol, and common peppermint oil on the market is adopted as the peppermint oil.
The example 8, the control example and the essential balm were applied to 30 patients bitten by mosquitoes and stabbed by caterpillars respectively by using the inunction method, and the treatment effects are shown in the following table 1:
TABLE 1-EXAMPLE 8 statistics of the usage of the Chinese medicinal gel for preventing and treating mosquito bites and the commercial essential balm in the control example
In table 1, the effective criteria for the therapeutic effect are: the effects of relieving itching and pain can be achieved after the medicine is used, the swelling can be basically and completely reduced after the medicine is used for 2 to 4 times, and the interval between every two uses is 1 to 2 hours; the judgment criteria of ineffective curative effect are as follows: the itching and pain are not obviously reduced after the medicine is used, and the swelling and pain feeling still exists after the medicine is used for 5 times.
As can be seen from table 1, the traditional Chinese medicine gel for preventing and treating mosquito bites in example 8 has a good treatment effect compared with the control example and the essential balm, wherein the effective rate of treating mosquito bites in example 8 is 100%, and the effective rate of treating caterpillar bites or bites can reach 96.7%; the effective rate of the contrast example for treating mosquito bites is 93.3 percent, and the effective rate of the contrast example for treating the caterpillar stabs is only 76.7 percent; the effective rate of the essential balm for treating mosquito bites is only 73.3 percent, and the effective rate for treating the caterpillar stabs is only 16.7 percent. Therefore, the effective rate of the example 8 in treating the mosquito bites and the caterpillar bites is far higher than that of the control example and the essential balm, so that the traditional Chinese medicine gel for preventing and treating the mosquito bites has good curative effects of relieving pain and itching and quickly diminishing swelling and dispelling toxicity.
Typical cases are as follows:
case 1: in the case that a male is in the age of 34, and the lower leg of the male is bitten by mosquitoes, the Chinese medicinal gel for preventing and treating the mosquito bites, which is prepared in the embodiment 2, is used, after the 1 st inunction, the itching and pain feeling is obviously eliminated, and after the 2 th inunction, the itching and pain feeling is completely eliminated, and the swelling is basically and completely eliminated.
Case 2: when a woman in the age of 42 and an arm of the woman in the age of 42 are bitten by mosquitoes, the traditional Chinese medicine gel for preventing and treating the mosquito bites, which is prepared in the embodiment 4, is externally applied for 1 time, the swelling and pain feeling is obviously eliminated, and after the traditional Chinese medicine gel is externally applied for 2 times, the swelling and pain feeling is completely eliminated.
Case 3: zhangyi, female, 42 years old, ankle of which was bitten by common venomous snake, using the Chinese medicinal gel for preventing and treating mosquito bite prepared in example 1, after the first external application, the itching and pain sensation was obviously eliminated, and after the external application was carried out for 4 times, the wound was healed, and the swelling was basically and completely eliminated.
Case 4: in songzhi, male, age 11, four limbs and face were bitten by mosquitoes, the swelling and pain was clearly removed after 2 applications of the Chinese medicinal gel for preventing and treating mosquito bites prepared in example 3.
Case 5: when a male aged for 67 years old and the left hand and face of the male aged are bitten by poisonous bees, the traditional Chinese medicine gel for preventing and treating mosquito bites prepared in the embodiment 5 is used, the itching and pain feeling is obviously eliminated after the hand is externally applied for the first time, and the swelling is basically completely reduced after the face is externally applied for 4 times.
Case 6: after the gel for preventing and treating mosquito bites, which is prepared in example 5, is applied to a woman in age of 13 and the arms, legs and feet of the woman bitten by mosquitoes, the swelling and pain feeling is obviously eliminated.
Case 7: after the traditional Chinese medicine gel for preventing and treating mosquito bites, which is prepared in example 5, is applied to male, 24-year-old, arms, legs and feet of the male to be bitten by mosquitoes, the swelling and pain feeling is obviously eliminated.
Case 8: lie, male, age 35; qiu, male, age 41; the two were simultaneously applied to different experimental environments with the same amount of mosquitoes, wherein arms, legs and faces of the duan were coated with the Chinese medicinal gel for preventing and treating mosquito bites prepared in example 8, the duan was not coated with any mosquito repellent preparation, no mosquito was close to the duan within 30 minutes, and the arms and thighs of the duan were respectively bitten by the mosquito.
Therefore, the traditional Chinese medicine gel for preventing and treating mosquito bites has good effects of relieving itching, relieving pain and diminishing swelling for mosquito bites, and has the effect of preventing mosquito bites.
It should be noted that the above mentioned embodiments are only preferred embodiments of the present invention, and not intended to limit the present invention, and any modification, equivalent replacement, improvement, etc. of the external dosage forms such as gel, ointment, cream, tincture, plaster, aerosol, spray, etc. made by the present invention shall be included in the protection scope of the present invention.
In this document, terms such as "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The traditional Chinese medicine gel for preventing and treating mosquito bites is characterized by consisting of a traditional Chinese medicine extract composition and a gel matrix, wherein the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 1-10 parts of clove oil, 1-10 parts of cinnamon oil, 1-20 parts of eucalyptus oil, 1-20 parts of camphor, 1-20 parts of methyl salicylate, 10-40 parts of menthol and 10-40 parts of peppermint oil.
2. The traditional Chinese medicine gel for preventing and treating mosquito bites according to claim 1, wherein the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 3-8 parts of clove oil, 3-8 parts of cinnamon oil, 5-15 parts of eucalyptus oil, 5-15 parts of camphor, 5-15 parts of methyl salicylate, 15-35 parts of menthol and 15-35 parts of peppermint oil.
3. The traditional Chinese medicine gel for preventing and treating mosquito bites according to claim 2, wherein the traditional Chinese medicine extract composition is prepared from the following raw materials in parts by weight: 5 parts of clove oil, 5 parts of cinnamon oil, 10 parts of eucalyptus oil, 10 parts of camphor, 10 parts of methyl salicylate, 25 parts of menthol and 25 parts of peppermint oil.
4. The traditional Chinese medicine gel for preventing and treating mosquito bites according to any one of claims 1 to 3, wherein the menthol is the pharmaceutical adjuvant menthol produced by Anhui Huaxin Biotechnology Limited; the peppermint oil is medicinal adjuvant peppermint oil with purity of 78% produced by Anhui Huaxin Biotechnology limited.
5. The traditional Chinese medicine gel for preventing and treating mosquito bites according to claim 1, wherein the clove oil, cinnamon oil and eucalyptus oil are all clove oil, cinnamon oil and eucalyptus oil produced by Anhui Huaxin Biotechnology Limited.
6. The traditional Chinese medicine gel for preventing and treating mosquito bites according to claim 1, wherein high-purity clove oil is adopted as the clove oil.
7. The preparation method of the traditional Chinese medicine gel for preventing and treating mosquito bites as claimed in claim 1, is characterized by comprising the following steps:
(1) sequentially adding oleum Caryophylli, oleum Cinnamomi, oleum Eucalypti, Camphora, and methyl salicylate into oleum Menthae Dementholatum;
(2) mixing the mixture obtained in the step (1), and filtering to remove residues;
(3) adding menthol into the mixture treated in the step (2), and fully stirring and uniformly mixing;
(4) adding appropriate amount of gel matrix, stirring, and mixing to obtain Chinese medicinal gel.
8. The method for preparing a Chinese medicinal gel for preventing and treating mosquito bite according to claim 7, wherein the gel matrix in the step (4) is prepared by:
(4.1) uniformly mixing a proper amount of carbomer, glycerol and water;
(4.2) adding dilute hydrochloric acid to adjust the pH value;
and (4.3) slightly draining the alkali liquor to the mixture prepared in the step (4.2), and slowly stirring until a bubble-free and ultra-fine gel matrix is formed.
9. The preparation method of the traditional Chinese medicine gel for preventing and treating mosquito bites according to claim 7, wherein the weight parts of the components in the step (1) and the step (3) are as follows: 5 parts of clove oil, 5 parts of cinnamon oil, 10 parts of eucalyptus oil, 10 parts of camphor, 10 parts of methyl salicylate, 25 parts of menthol and 25 parts of peppermint oil.
10. The method for preparing a Chinese medicinal gel for preventing and treating mosquito bite according to claim 7, wherein the menthol is prepared from menthol belonging to pharmaceutical adjuvant class produced by Anhui Huaxin Biotechnology limited; the peppermint oil is medicinal adjuvant peppermint oil with purity of 78% produced by Anhui Huaxin Biotechnology limited.
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| CN115400172A (en) * | 2022-10-28 | 2022-11-29 | 辽宁中医药大学附属医院 | Traditional Chinese medicine composition for treating mosquito bites and preparation method thereof |
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Non-Patent Citations (1)
| Title |
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| 鲍大荣: "清凉油治疗丘疹性荨麻疹30例临床分析", 《右江民族医学院学报》 * |
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| CN115400172A (en) * | 2022-10-28 | 2022-11-29 | 辽宁中医药大学附属医院 | Traditional Chinese medicine composition for treating mosquito bites and preparation method thereof |
| CN115400172B (en) * | 2022-10-28 | 2023-09-15 | 辽宁中医药大学附属医院 | A Chinese medicinal composition for treating insect bite, and its preparation method |
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Application publication date: 20220510 |