CN115400172A - Traditional Chinese medicine composition for treating mosquito bites and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating mosquito bites and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating mosquito bites and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-6 parts of notopterygium root, 1-4 parts of rhubarb, 1-4 parts of radix bupleuri, 1-6 parts of rhizoma atractylodis, 1-6 parts of asarum and 1-4 parts of fructus evodiae. According to the traditional Chinese medicine composition for treating mosquito bites, a plurality of traditional Chinese medicines are formulated according to the compatibility principle of the traditional Chinese medicines, so that the components supplement each other to generate a good synergistic effect, and the medicines are combined to play the effects of perfuming, avoiding dirty, dispelling wind, relieving itching, reducing swelling and relieving pain. Clinical researches show that the invention has good effect on itching and swelling caused by mosquito bites.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition for treating mosquito bites and a preparation method thereof.
Background
In summer, after the skin is bitten by mosquitoes, saliva in salivary glands of the mosquitoes is injected into the skin, and the saliva contains various anticoagulant chemical substances, so that ecchymosis appears on the skin at the bitten part; meanwhile, saliva of mosquitoes contains allergy-related proteins such as salivary allergens, natural antigen proteins and adenosine deaminase, and the substances cause local or whole-body allergy after a human body is bitten, and are expressed by that pimples, wheal, edematous erythema, blisters, herpes simplex, petechia petechiae and the like appear on the bitten part, biting marks can be seen in the center of skin damage, and people feel prickled, burning and itching in different degrees, wherein the skin itch is the most common, and troubles are brought to the life of people.
At present, an external preparation is mainly adopted for the symptoms, common medicines are mostly anti-allergic and hormone western medicines such as diphenhydramine, dermatitis and the like, the long-term use of the external preparation can not only generate drug resistance, but also possibly cause wound pigmentation, further cause side effects such as wound skin atrophy, secondary infection and the like, and children need to use the external preparation with caution. Alkaline substances such as soap water, sodium bicarbonate or ammonia water are used for neutralizing acidic venom of mosquitoes to relieve redness and swelling, and toilet water and the like are used for scrubbing bites to relieve itching, so that the effect is not obvious. In the market, floral water is mainly prepared from anophelifuge, alcohol, menthol, borneol, thymol, camphor, essence, alcohol and deionized water, and has the effects of cooling and dispelling miliaria and little effect on insect dermatitis. The anophelifuge contained in the floral water can induce asthma and other diseases, and can cause cancer and teratogenesis after long-term use. Some toilet water is added with salicylic acid compounds to achieve an anti-inflammatory effect, but the salicylic acid compounds have high permeability, so that the toilet water not only stimulates the skin, but also dries the skin.
The traditional Chinese medicine considers that the skin is infected with toxin after mosquitoes bite the human body, so that the channels and collaterals are blocked, the circulation of qi and blood is further influenced, a series of symptoms such as red swelling, itching and pain appear, the vexation is further caused, and the life of a patient is influenced. The traditional Chinese medicine composition starts from two aspects of prevention and treatment, not only utilizes the aromaticity and the fragrance of the medicine to avoid dirts, but also achieves the effects of dispelling wind, relieving itching, reducing swelling and relieving pain. So as to achieve the treatment effect on red, swollen, painful and itchy skin after the mosquito bites, and has important significance in combination of prevention and treatment.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for treating mosquito bites and a preparation method thereof. The medicines are combined to play the effects of aromatic and avoiding dirty, dispelling wind and relieving itching, and reducing swelling and relieving pain, and have good effect on itching and swelling caused by mosquito bites.
In order to achieve the above object, the present invention provides the following technical solutions.
The invention provides a traditional Chinese medicine composition for treating mosquito bites, which is characterized by comprising the following raw materials in parts by weight: 1-6 parts of notopterygium root, 1-4 parts of rhubarb, 1-4 parts of radix bupleuri, 1-6 parts of rhizoma atractylodis, 1-6 parts of asarum and 1-4 parts of fructus evodiae.
Further, the traditional Chinese medicine composition is prepared from the following raw medicines in a preferable weight ratio: 1-4 parts of notopterygium root, 1-2 parts of rhubarb, 1-2 parts of radix bupleuri, 1-4 parts of rhizoma atractylodis, 1-4 parts of asarum and 1-2 parts of fructus evodiae.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in an optimal weight ratio: 1 part of notopterygium root, 1 part of rhubarb, 1 part of radix bupleuri, 1 part of rhizoma atractylodis, 1 part of asarum and 1 part of fructus evodiae.
Further, the use of the traditional Chinese medicine composition according to any one of the above in the preparation of a preparation for treating mosquito bites.
The invention also provides a pharmaceutical composition for treating mosquito bites, which is characterized by comprising the traditional Chinese medicine composition as claimed in any one of claims 1 to 3 and pharmaceutically acceptable auxiliary materials.
Further, the dosage form of the pharmaceutical composition can be prepared into any suitable external preparation according to requirements.
The invention also provides a preparation method of the gel of the pharmaceutical composition for treating mosquito bite, which is characterized by comprising the following steps:
step (1): extracting volatile oil: weighing the notopterygium root, the rheum officinale, the radix bupleuri, the rhizoma atractylodis, the asarum and the fructus evodiae accurately according to the parts by weight of any one of the above raw materials, mixing, crushing into coarse particles, soaking for 0.5-1.5 h by using pure water with the weight 6-10 times of that of the raw materials, extracting for 4 hours by adopting a steam distillation method until the volatile oil amount is not increased any more, and collecting the volatile oil in another container;
step (2): adding deionized water into carbomer, stirring, and naturally swelling overnight to obtain 0.5% carbomer solution;
and (3): adding Tween 80 into the solution obtained in the step (2) to prepare a 0.5% carbomer solution containing Tween 80 with the concentration of 2%;
and (4): dropwise adding the volatile oil extracted in the step (1) into the solution in the step (3), and stirring until the solution is clear, so as to prepare a solution in the step (2) containing the volatile oil with the concentration of 0.2%;
and (5): adding triethanolamine into the solution obtained in the step (4) dropwise to adjust the pH value to 7;
and (6): and (5) filling to obtain the gel of the medicine.
The invention also provides a preparation method of the spray of the medicinal composition for treating mosquito bites, which is characterized by comprising the following steps:
step (1): extracting volatile oil: weighing the notopterygium root, the rheum officinale, the radix bupleuri, the rhizoma atractylodis, the asarum and the fructus evodiae accurately according to the parts by weight of any one of the above raw materials, mixing, crushing into coarse particles, soaking for 0.5-1.5 h by using pure water with the weight 6-10 times of that of the raw materials, extracting for 4 hours by adopting a steam distillation method until the volatile oil amount is not increased any more, and collecting the volatile oil in another container;
step (2): adding Tween 80 into pure water to obtain solution containing Tween 80 of 2%;
and (3): dripping the volatile oil extracted in the step (1) into the solution in the step (2), and stirring to prepare the solution in the step (2) containing the volatile oil with the concentration of 0.2 percent;
and (4): taking the solution in the step (3), and dropwise adding NaHCO 3 Adjusting the pH value of the solution to 7 to obtain the product;
and (5): and (5) filling to obtain the medicinal spray.
Further, the application of the medicine composition for treating mosquito bites, which is prepared by the preparation method, in medicines for treating mosquito bites.
The traditional Chinese medicine composition has the following effects and pharmacological actions.
Notopterygii rhizoma is dried rhizome and root of Notopterygii rhizoma of Umbelliferae. Pungent, bitter and warm. It enters bladder and kidney meridians. Relieve exterior syndrome, dispel cold, expel wind and remove dampness, and alleviate pain. Can be used for treating wind-cold type common cold, headache, stiff neck, rheumatalgia, and soreness of shoulder and back. Research shows that the high, medium and low doses of the notopterygium root volatile oil can obviously inhibit mouse ear swelling caused by xylene and has good anti-inflammatory effect; the notopterygium root volatile oil high-dose group can obviously reduce the body twisting frequency of mice caused by acetic acid, and the analgesic rate can reach 47.15%; the water extract of Notopterygii rhizoma has no obvious analgesic effect, and the component with analgesic effect in Notopterygii rhizoma is volatile oil.
The radix et rhizoma Rhei is dry root and rhizome of Rheum palmatum L., rheum tanguticum Maxim. Ex Balf. Or Rheum officinale Baill. Of Polygonaceae. Bitter and cold. It enters spleen, stomach, large intestine, liver and pericardium meridians. Purgation, eliminating accumulation, clearing heat-fire, cooling blood, removing toxicity, removing blood stasis, dredging meridians, promoting diuresis and relieving jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, intestinal carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal blood stasis, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it can be used for external treatment of burn and scald. Modern researches show that rhubarb can clear away inflammatory substances in organism including tissues and blood plasma, reduce the levels of interleukin and tumor necrosis factor in blood serum, and reduce the generation of endotoxin to achieve the effects of resisting bacteria and diminishing inflammation.
The bupleuri radix is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae. Pungent, bitter and slightly cold. It enters liver, gallbladder and lung meridians. Disperse and abate fever, soothe the liver and relieve depression, lift yang qi. Can be used for treating common cold, fever, alternating chills and fever, and distending pain in chest and hypochondrium. Research shows that the bupleurum chinense distilled liquid can increase the tolerance of a mouse to pain, and the bupleurum chinense volatile oil can inhibit the mouse ear swelling and capillary permeability caused by xylene, so that the bupleurum chinense volatile oil has certain anti-inflammatory and analgesic effects.
Rhizoma Atractylodis is dried rhizome of Atractylodes lancea or Atractylodes chinensis of Compositae. Pungent, bitter and warm. It enters spleen, stomach and liver meridians. Dry dampness and invigorate spleen, dispel wind and cold, improve vision. Can be used for treating retention of dampness in middle warmer, abdominal distention, diarrhea, edema, tinea pedis, atrophy 36484, rheumatalgia, wind cold type common cold, night blindness, dim eyesight, and astringency. Research shows that the rhizoma atractylodis volatile oil part has obvious influence on the inhibition rate of mouse writhing reaction caused by acetic acid, and the rhizoma atractylodis volatile oil has the function of inhibiting mouse auricle swelling, which shows that the rhizoma atractylodis volatile oil has obvious anti-inflammatory and analgesic effects.
The herba asari is dried root and rhizome of Aristolochiaceae plant such as herba asari Forbesii, herba asari Forbesii or herba asari Sinici. Pungent and warm. It enters heart, lung and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifices, warming lung, and eliminating phlegm. Can be used for treating common cold due to wind-cold, headache, toothache, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, rheumatic arthralgia, phlegm and fluid retention, and cough and asthma. Researches show that asarum volatile oil is irrigated by rabbits at a concentration of 0.2 to 0.5mL/kg, and has an antipyretic effect on artificial fever caused by warm thorns, vaccines and tetrahydro-beta-naphthylamine; for a rat fever model caused by yeast suspension, after 0.11mL/kg of asarum volatile oil is injected into the abdominal cavity, the antipyretic effect is obvious; the main component of the volatile oil in the asarum is methyl eugenol, can relieve the edema degree of nasal mucosa glands and reduce gland secretion by up-regulating the expression of AQP5, thereby relieving the symptoms of allergic rhinitis, nasal itching, sneezing, watery nasal discharge and the like, and the alpha-asarone has the inhibiting effect on immune inflammatory reaction of rat microglia cells induced by lipopolysaccharide.
The fructus evodiae is dried nearly mature fruit of Rutaceae plant fructus evodiae, caulis Seu folium Ampelopsis Brevipedunculatae or Rutaceae fructus evodiae. Pungent, bitter and hot; has little toxicity. It enters liver, spleen, stomach and kidney meridians. Dispel cold and alleviate pain, check adverse rise of qi and arrest vomiting, strengthen yang and check diarrhea. Can be used for treating syncope headache, hernia of cold, abdominal pain, tinea pedis due to cold dampness, abdominal pain during menstruation, abdominal pain, emesis, acid regurgitation, and diarrhea before dawn. Modern researches respectively discuss the analgesic effect of the evodia rutaecarpa volatile oil and the water extract on mice, and the results show that the evodia rutaecarpa volatile oil and the water extract have an antagonistic effect on the writhing reaction of the mice caused by acetic acid, thereby determining the analgesic effect of the evodia rutaecarpa volatile oil and reflecting the relevance of the drug property and the effect of the volatile oil.
Notopterygium root, bupleurum root, rhizoma atractylodis, asarum and evodia fruit are all aromatic traditional Chinese medicines, the action mechanism of the aromatic medicines is disclosed in Shennong herbal records, the positive qi is healthy, the vital qi is strong, the pathogenic factors are removed and the dirt is removed, and the Qing Dynasty Wu Shangxian considers that the aromatic volatile oil has the main effects of 'leading the group medicines to be separated and stagnated, directly reaching the focus, so as to attack the focus, and no objection exists, namely, the aromatic volatile oil is attributed to qi and blood circulation, but the disease is self-developed'. It is indicated that the aromatic herbs can dispel foul epidemic qi to achieve the effect of supporting healthy qi by means of their clear healthy qi, and most of them have the action of relieving exterior syndrome and expelling pathogenic factors to achieve the effect of supporting healthy qi. Notopterygium root is good at relieving exterior cold, dispelling wind-damp and stopping arthralgia; cang Zhu Gong is good at drying dampness and dispelling wind and cold; asarum herb can dispel wind and cold, especially can alleviate pain; the radix bupleuri disperses the pathogenic heat to abate fever; fructus evodiae dispels cold to relieve pain; the above medicines are used together to dispel wind-cold-dampness evil to eliminate etiological factors and promote qi and blood circulation to relieve pain. Da Huang Gong excels in clearing heat and removing toxicity, cooling blood and relieving swelling, and is combined with herbs to relieve interior heat toxicity caused by mosquito bites. The medicines are used together to play the effects of aromatic and avoiding dirty, dispelling wind and relieving itching, and detumescence and relieving pain. Modern pharmaceutical research shows that volatile oil components in notopterygium root, radix bupleuri, rhizoma atractylodis, asarum and fructus evodiae in the formula have antipyretic, analgesic and anti-inflammatory effects, and the volatile oil components can play a definite treatment role on red, swelling, pain and itching of skin after mosquito bites by matching with the antibacterial and anti-inflammatory effects of rheum officinale.
Compared with the prior art, the invention has the beneficial effects.
Notopterygium root, bupleurum root, atractylodes rhizome, asarum and evodia fruit are aromatic traditional Chinese medicines, and most of the aromatic medicines have the effects of relieving exterior syndrome and expelling pathogenic factors. The medicines are used together to play the effects of aromatic and avoiding dirty, dispelling wind and relieving itching, and detumescence and relieving pain. The research experiment result shows that the pharmaceutical composition has an inhibiting effect on mouse skin itch caused by dextran and has an anti-inflammatory effect on mouse ear swelling caused by xylene. Clinical researches show that the invention has good effect on itching and swelling caused by mosquito bites.
Detailed Description
The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the specific material ratios, process conditions and results thereof described in the examples are illustrative only and should not be taken as limiting the invention as detailed in the claims.
Example 1 gel preparation of the inventive medicament.
1. A traditional Chinese medicine composition for treating mosquito bites is prepared from the following medicinal materials in parts by weight: 1 part of notopterygium root, 1 part of rhubarb, 1 part of radix bupleuri, 1 part of rhizoma atractylodis, 1 part of asarum and 1 part of fructus evodiae.
2. A preparation method of a traditional Chinese medicine composition for treating mosquito bites comprises the following steps.
Step (1): extracting volatile oil: mixing the above materials, pulverizing into coarse powder, soaking in 8 times of pure water for 1 hr, extracting by steam distillation for 4 hr until the volatile oil amount is not increased, and collecting volatile oil in another container.
Step (2): taking a proper amount of carbomer, adding deionized water, stirring, and naturally swelling overnight to obtain a carbomer solution with a concentration of 0.5%.
And (3): and (3) adding a proper amount of Tween 80 into the solution in the step (2) to prepare a 0.5% carbomer solution containing Tween 80 with the concentration of 2%.
And (4): and (3) dropwise adding the volatile oil extracted in the step (1) into the solution in the step (3), and stirring until the solution is clear, thus preparing the solution in the step (2) with the volatile oil concentration of 0.2%.
And (5): and (4) dropwise adding triethanolamine into the solution obtained in the step (4) to adjust the pH value to 7.
And (6): and (5) filling to obtain the gel of the medicine.
Example 2 spray preparation of the inventive medicament.
Step (1): extracting volatile oil: mixing the above materials, pulverizing into coarse powder, soaking in 8 times of pure water for 1 hr, extracting by steam distillation for 4 hr until the volatile oil amount is not increased, and collecting volatile oil in another container.
Step (2): adding appropriate amount of Tween 80 into pure water to obtain solution containing Tween 80 of 2%.
And (3): and (3) dropwise adding the volatile oil extracted in the step (1) into the solution in the step (2), and stirring to prepare the solution in the step (2) with the volatile oil concentration of 0.2%.
And (4): taking the solution in the step (3), and dropwise adding NaHCO 3 Adjusting the pH value of the solution to 7 to obtain the product.
And (5): and (5) filling to obtain the medicinal spray.
Example 3 an experiment for inhibiting dextran-induced skin itch in mice with a Chinese medicinal composition for treating mosquito bites.
Experimental animals and grouping: the SPF Kunming (KM) mice are divided into 5 experimental groups of 50 mice with half male and female, namely a blank control group, a model group, a traditional Chinese medicine gel group, a traditional Chinese medicine spray group and a certain brand floral water control group, wherein each group comprises 10 mice with half male and female.
The experimental method comprises the following steps: the day before the experiment, the back of each group of mice was depilated with depilatory cream, and the area was 2X 2cm 2 On the day of an experiment, a model group, a traditional Chinese medicine gel group and a traditional Chinese medicine spray group are used, 0.01% dextran (10 mL/kg) is injected into tail veins of mice in each group of a certain brand floral water control group, isometric normal saline is injected into a blank group, after injection, the traditional Chinese medicine gel is uniformly coated on a depilated part of the traditional Chinese medicine gel group, traditional Chinese medicine spray is coated on the traditional Chinese medicine spray group, the normal saline is coated on the blank group and the model group, floral water is coated on the control group, the front paw of the mice scratches the head part, the rear paw scratches the trunk, and the mouth bites each part of the body and the tail as itching reaction indexes. And observing and recording the pruritus frequency and the pruritus duration total time of each group of mice within 30min of each mouse, performing data statistics, and evaluating the antipruritic effect of the medicament.
Table 1 shows the frequency and duration of the action of the Chinese medicinal composition on the skin itch of mice caused by dextran.
# And comparing with the model group.
Example 4 an anti-inflammatory test of swelling of mouse ear caused by p-xylene with a Chinese medicinal gel for treating mosquito bite.
Experimental animals and grouping: the SPF Kunming (KM) mice are divided into 4 experimental groups of 40 mice with half male and female, wherein the experimental groups are respectively a model group, a traditional Chinese medicine gel group, a traditional Chinese medicine spray group and a certain brand floral water control group, and each group comprises 10 mice with half male and female.
The experimental method comprises the following steps: each group of mice was inflamed by 0.05mL xylene in the left ear and control in the right ear. After inflammation is caused for 30min, a model group mouse is given to a left auricle internal and external smearing physiological saline 0.5mL, a traditional Chinese medicine gel group and a traditional Chinese medicine spraying agent group mouse is given to a left auricle internal and external smearing traditional Chinese medicine gel 0.5mL and a traditional Chinese medicine spraying agent group mouse is given to a left auricle internal and external smearing floral water 0.5mL, after the left auricle and the traditional Chinese medicine spraying agent group mouse are smeared for 60min, the neck of the mouse is dislocated and killed, double ears are cut off, round ear pieces are respectively punched at the same positions of the left ear and the right ear by a puncher with the diameter of 8mm, weighing is carried out, the left ear is used as a reference, the mass difference of the left ear and the right ear pieces is the swelling degree, the swelling degree of each group is calculated, and the swelling inhibition rate is calculated according to a formula. Inhibition = (degree of swelling in model group-degree of swelling in drug group))/degree of swelling in model group × 100%.
Table 2 inhibition rate of the Chinese medicinal gel to swelling of mouse ear caused by p-xylene.
Example 4 observation of the effect of a Chinese medicinal gel for treating mosquito bites.
Observing an object: 50 cases were collected in 6-2022 in 2021 month. The traditional Chinese medicine gel groups comprise 30 cases, 17 cases for men and 13 cases for women; the age is 5-60 years.
Inclusion criteria were: the clinical symptoms mainly comprise mosquito and insect bites, local pruritus, heat and pain, and no suppuration and infection focus.
Exclusion criteria: (1) Patients who have anaphylactic reaction phenomena to the medicines contained in the gel; (2) suffering from a psychiatric disorder or developing cognitive impairment.
The curative effect standard is as follows: (1) draw up the prescription according to the standard of curative effect of diagnosis of traditional Chinese medicine symptoms. And (3) curing: the skin lesions subside and the symptoms of subjective itching disappear. The effect is shown: the symptom of the subjective itching is obviously relieved, and the skin damage is relieved by more than 60 percent. Improvement: the subjective itching symptom is relieved, and the skin damage is relieved by 30-60%. The disease is not cured: there was no change in skin lesions and itching symptoms, or the skin lesions subsided less than 30%.
The using method comprises the following steps: the gel of the invention is proper in amount and can be uniformly applied to mosquito bites.
Table 3 observation of the effect of the Chinese medicinal gel for treating mosquito bite.
The gel of the composition has no skin irritation in the test process, and has no systemic or local adverse reaction.
Typical cases.
Case 1 Guan Mou, female, 39 years old. Before the product is used, after the mosquito bites the product, symptoms such as redness and swelling, pruritus and the like appear at the bite part, the bite part cannot be grabbed by the mosquito, and the redness and swelling can be gradually subsided after the bite part is bitten by the mosquito for two days. The gel is applied to the affected part 10 minutes after mosquito bites, after 5 minutes, pruritus symptoms are relieved, and symptoms such as red swelling, swelling and the like are relieved within 30 minutes. After the treatment, the ointment is used for a plurality of times when being bitten by mosquitoes, and has obvious curative effects of relieving itching and reducing swelling.
Case 2 Wang Mou, female, 5 years old. Before the product is not used, after the product is bitten by mosquitoes, pruritus, swelling and red swelling at the bitten part gradually disappear after 2 days. After 20 minutes after the mosquito bites, the itching subsides after 3 minutes and the swelling subsides after 30 minutes by using the gel. After being used for many times, the swelling-reducing and itching-relieving effects are obvious.
Case 3 Liu Mou, male, 30 years old. Before the product is not used, after the mosquito bites the product, the bite part is difficult to endure and feels pruritus, swelling and red swelling under the scratching condition. After 20 minutes after the mosquito bites, the itching symptom is obviously relieved by using the gel, and the swelling and the red swelling gradually disappear within 60 minutes. After being used for many times, the swelling-reducing and itching-relieving effects are obvious.
Claims (9)
1. The traditional Chinese medicine composition for treating mosquito bites is characterized by comprising the following raw materials in parts by weight: 1-6 parts of notopterygium root, 1-4 parts of rhubarb, 1-4 parts of radix bupleuri, 1-6 parts of rhizoma atractylodis, 1-6 parts of asarum and 1-4 parts of fructus evodiae.
2. The traditional Chinese medicine composition for treating mosquito bite as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in a preferable weight ratio: 1-4 parts of notopterygium root, 1-2 parts of rhubarb, 1-2 parts of radix bupleuri, 1-4 parts of rhizoma atractylodis, 1-4 parts of asarum and 1-2 parts of fructus evodiae.
3. The traditional Chinese medicine composition for treating mosquito bite as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in an optimal weight ratio: 1 part of notopterygium root, 1 part of rhubarb, 1 part of radix bupleuri, 1 part of rhizoma atractylodis, 1 part of asarum and 1 part of fructus evodiae.
4. Use of a Chinese medicinal composition according to any one of claims 1-3 in the preparation of a formulation for the treatment of mosquito bites.
5. A pharmaceutical composition for treating mosquito bites, which comprises the traditional Chinese medicine composition of any one of claims 1 to 3 and pharmaceutically acceptable excipients.
6. The pharmaceutical composition of claim 5, wherein the pharmaceutical composition can be prepared into any suitable external preparation according to requirements.
7. A preparation method of a gel of a pharmaceutical composition for treating mosquito bites is characterized by comprising the following steps:
step (1): extracting volatile oil: weighing Notopterygii rhizoma, radix et rhizoma Rhei, bupleuri radix, rhizoma Atractylodis, herba asari and fructus evodiae accurately according to the weight parts of any one of claims 1-3, mixing, pulverizing into coarse particles, soaking in pure water 6-10 times of the weight of the medicinal materials for 0.5-1.5 h, extracting by steam distillation for 4 hr until the volatile oil amount is not increased, and collecting the volatile oil in another container;
step (2): adding deionized water into carbomer, stirring, and naturally swelling overnight to obtain 0.5% carbomer solution;
and (3): adding Tween 80 into the solution in the step (2) to prepare a 0.5% carbomer solution containing Tween 80 with the concentration of 2%;
and (4): dropwise adding the volatile oil extracted in the step (1) into the solution obtained in the step (3), and stirring until the solution is clear, so as to prepare a solution containing 0.2% of volatile oil in the step (2);
and (5): adding triethanolamine dropwise into the solution obtained in the step (4) to adjust the pH value to 7;
and (6): and (5) filling to obtain the gel of the medicine.
8. A preparation method of a spray of a pharmaceutical composition for treating mosquito bites is characterized by comprising the following steps:
step (1): extracting volatile oil: weighing Notopterygii rhizoma, radix et rhizoma Rhei, bupleuri radix, rhizoma Atractylodis, herba asari and fructus evodiae accurately according to the weight parts of any one of claims 1-3, mixing, pulverizing into coarse particles, soaking in pure water 6-10 times of the weight of the medicinal materials for 0.5-1.5 h, extracting by steam distillation for 4 hr until the volatile oil amount is not increased, and collecting the volatile oil in another container;
step (2): adding Tween 80 into pure water to obtain solution containing Tween 80 of 2%;
and (3): dripping the volatile oil extracted in the step (1) into the solution in the step (2), and stirring to prepare the solution in the step (2) containing the volatile oil with the concentration of 0.2 percent;
and (4): taking the solution in the step (2), and dropwise adding NaHCO 3 Adjusting the pH value of the solution to 7 to obtain the product;
and (4): and (5) filling to obtain the medicinal spray.
9. Use of the pharmaceutical composition for the treatment of mosquito bites prepared by the preparation method according to any one of claims 7 to 8 in the preparation of a medicament for the treatment of mosquito bites.
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| CN1698739A (en) * | 2005-04-16 | 2005-11-23 | 刘希山 | Externally applied Chinese medicine preparation for treating skin disease and its preparation method |
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| CN103655779A (en) * | 2013-12-27 | 2014-03-26 | 耿丽 | Pharmaceutical composition for treating mosquito and insect bite |
| CN212877691U (en) * | 2020-03-06 | 2021-04-06 | 浙江博尼时尚控股集团有限公司 | Mask with filtering insert |
| CN114452319A (en) * | 2022-03-07 | 2022-05-10 | 安徽华馨生物科技有限公司 | A Chinese medicinal gel for preventing and treating mosquito bite, and its preparation method |
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| CN1698739A (en) * | 2005-04-16 | 2005-11-23 | 刘希山 | Externally applied Chinese medicine preparation for treating skin disease and its preparation method |
| CN101491575A (en) * | 2008-12-18 | 2009-07-29 | 浙江省中医院 | Traditional Chinese medicine extract for treating atopic dermatitis and granules thereof |
| CN103655779A (en) * | 2013-12-27 | 2014-03-26 | 耿丽 | Pharmaceutical composition for treating mosquito and insect bite |
| CN212877691U (en) * | 2020-03-06 | 2021-04-06 | 浙江博尼时尚控股集团有限公司 | Mask with filtering insert |
| CN114452319A (en) * | 2022-03-07 | 2022-05-10 | 安徽华馨生物科技有限公司 | A Chinese medicinal gel for preventing and treating mosquito bite, and its preparation method |
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