CN115400172B - A Chinese medicinal composition for treating insect bite, and its preparation method - Google Patents
A Chinese medicinal composition for treating insect bite, and its preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating mosquito bites and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1-6 parts of notopterygium root, 1-4 parts of rheum officinale, 1-4 parts of radix bupleuri, 1-6 parts of rhizoma atractylodis, 1-6 parts of asarum, and 1-4 parts of fructus evodiae. According to the traditional Chinese medicine composition for treating mosquito bites, a plurality of traditional Chinese medicines are combined according to the compatibility principle of traditional Chinese medicines, so that all the components complement each other to generate good synergistic effect, and the combination of the medicines has the effects of aromatic and dirt-removing, wind dispelling and itching relieving, detumescence and pain relieving. Clinical researches show that the invention has good effect on itching and swelling caused by mosquito bites.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating mosquito bites and a preparation method thereof.
Background
In summer, after mosquitoes bite the skin, saliva in salivary glands is injected into the skin, and the saliva contains various anticoagulation chemical substances, so that ecchymosis occurs on the skin at the biting position; meanwhile, saliva of mosquitoes contains saliva allergen, natural antigen protein, adenosine deaminase and other allergic reaction related proteins, and the substances cause local or systemic allergic reaction after a human body is bitten, which is manifested by pimple, wind cluster, edema erythema, blister, cumulus herpes, ecchymosis and the like on the local bitten part, the biting trace is visible in the center of skin damage, and stings, burning pain and itching with different degrees are subjective, wherein skin itching is the most common, and the life of people is plagued.
At present, an external preparation is mainly adopted for the symptoms, most of commonly used medicines are antiallergic and hormonal western medicines such as diphenhydramine and dermatitis, and the like, so that the medicine resistance can be generated after long-term use, the pigmentation of the wound surface can be caused, and further, the side effects of skin atrophy, secondary infection and the like of the wound surface can be caused, and the medicine should be used with cautions for children. The acidic venom of mosquitoes is neutralized by alkaline substances such as soapy water, baking soda or ammonia water to relieve red swelling, and the biting parts are scrubbed by floral water to relieve itching, so that the effect is not obvious. The raw materials of the toilet water in the market are mostly mosquito repellent ester, alcohol, menthol, borneol, thymol, camphor, essence, alcohol and deionized water, and the toilet water has the effects of cooling and removing miliaria and has very little effect on insect bite dermatitis. The mosquito repellent ester contained in the floral water can induce diseases such as asthma and the like, and can also cause cancer and teratogenesis after long-term use. Some toilet water is added with salicylic acid compound to achieve anti-inflammatory effect, but the salicylic acid compound has too high permeability, so that the toilet water not only stimulates the skin, but also can dry the skin.
The traditional Chinese medicine considers that the mosquito bites the human body to cause skin to pollute the toxin, so that the channels and collaterals are blocked, the operation of qi and blood is further influenced, a series of symptoms such as redness, swelling, itching and pain are further caused, and the life of a patient is further influenced. The traditional Chinese medicine composition provided by the invention starts from two aspects of prevention and treatment, not only utilizes the aromaticity and aroma of the medicine to avoid dirt, achieves the effect of expelling mosquito, but also has the effects of dispelling wind, relieving itching, reducing swelling and relieving pain. So as to achieve the treatment effect on red, swelling, pain and itching of the skin after the mosquito bites, and has important significance in combination of prevention and treatment.
Disclosure of Invention
Aiming at the problems, the invention provides a traditional Chinese medicine composition for treating mosquito bites and a preparation method thereof. The medicines are combined to play roles of aromatic and dirt-removing, wind-dispelling and itching-relieving, and detumescence and pain-relieving, and have good effects on itching and swelling caused by mosquito bites.
In order to achieve the above purpose, the present invention provides the following technical solutions.
The invention provides a traditional Chinese medicine composition for treating mosquito bites, which is characterized by comprising the following raw materials in parts by weight: 1-6 parts of notopterygium root, 1-4 parts of rheum officinale, 1-4 parts of radix bupleuri, 1-6 parts of rhizoma atractylodis, 1-6 parts of asarum, and 1-4 parts of fructus evodiae.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in a preferable weight ratio: 1-4 parts of notopterygium root, 1-2 parts of rheum officinale, 1-2 parts of radix bupleuri, 1-4 parts of rhizoma atractylodis, 1-4 parts of asarum and 1-2 parts of fructus evodiae.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in an optimal weight ratio: 1 part of notopterygium root, 1 part of rheum officinale, 1 part of radix bupleuri, 1 part of rhizoma atractylodis, 1 part of asarum and 1 part of fructus evodiae.
Further, the use of the traditional Chinese medicine composition according to any one of the above-mentioned claims for preparing a preparation for treating mosquito bites.
The invention also provides a pharmaceutical composition for treating mosquito bites, which is characterized by comprising the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
Further, the dosage form of the pharmaceutical composition can be prepared into any suitable external preparation according to the requirement.
The invention also provides a preparation method of the gel of the pharmaceutical composition for treating mosquito bites, which is characterized by comprising the following steps:
step (1): extracting volatile oil: accurately weighing the notopterygium root, the rheum officinale, the bupleurum, the rhizoma atractylodis, the asarum and the evodia rutaecarpa according to the parts by weight, mixing, crushing into coarse particles, soaking for 0.5-1.5 h by pure water with the weight of 6-10 times that of the medicinal materials, extracting by a steam distillation method for 4 hours until the volatile oil amount is not increased any more, and collecting the volatile oil in another container;
step (2): adding deionized water into carbomer, stirring, and naturally swelling overnight to obtain carbomer solution with concentration of 0.5%;
step (3): adding Tween 80 into the solution obtained in the step (2) to prepare a 0.5% carbomer solution containing 2% of Tween 80;
step (4): dripping the volatile oil extracted in the step (1) into the solution obtained in the step (3), and stirring until the solution is clear, so as to prepare a solution with the volatile oil concentration of 0.2%;
step (5): taking the solution in the step (4), and dripping triethanolamine to adjust the pH value to 7;
step (6): and (5) filling to obtain the gel of the medicine.
The invention also provides a preparation method of the spray of the pharmaceutical composition for treating mosquito bites, which is characterized by comprising the following steps:
step (1): extracting volatile oil: accurately weighing the notopterygium root, the rheum officinale, the bupleurum, the rhizoma atractylodis, the asarum and the evodia rutaecarpa according to the parts by weight, mixing, crushing into coarse particles, soaking for 0.5-1.5 h by pure water with the weight of 6-10 times that of the medicinal materials, extracting by a steam distillation method for 4 hours until the volatile oil amount is not increased any more, and collecting the volatile oil in another container;
step (2): adding Tween 80 into pure water to obtain solution containing Tween 80 with concentration of 2%;
step (3): dripping the volatile oil extracted in the step (1) into the solution obtained in the step (2), and stirring to prepare a solution containing 0.2% of the volatile oil;
step (4): taking the solution in the step (3), and dripping NaHCO 3 Regulating the pH value of the solution to 7 to obtain the water-soluble organic compound;
step (5): and (5) filling to obtain the spray of the medicine.
Further, the pharmaceutical composition for treating mosquito bites prepared by any one of the preparation methods is applied to the medicines for treating mosquito bites.
The efficacy and pharmacological actions of the traditional Chinese medicine composition are as follows.
Notopterygium root is the dried rhizome and root of Notopterygium root of Umbelliferae. Pungent and bitter, warm. Enter bladder and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, removing dampness, and relieving pain. Can be used for treating common cold due to wind-cold, headache, arthralgia due to wind-dampness, and soreness of shoulder and back. Researches show that the high, medium and low doses of the notopterygium root volatile oil can obviously inhibit mouse ear swelling caused by dimethylbenzene, and have good anti-inflammatory effect; the high dosage group of the volatile oil of the notopterygium root can obviously reduce the twisting times of mice caused by acetic acid, and the pain relieving rate can reach 47.15%; the analgesic effect of the water extract of the notopterygium root is not obvious, and the component of the notopterygium root which has the analgesic effect is volatile oil.
The radix et rhizoma Rhei is dry root and rhizome of Rheum palmatum or Rheum tanguticum Maxim of Polygonaceae. Bitter and cold. It enters spleen, stomach, large intestine, liver and pericardium meridians. Purgation and accumulation, clearing heat and purging fire, cooling blood and detoxicating, removing blood stasis and dredging channels, promoting diuresis and removing jaundice. Can be used for treating constipation due to excessive heat accumulation, hematemesis, epistaxis, conjunctival congestion, pharyngeal swelling, carbuncle, furuncle, acute carbuncle, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, traumatic injury, damp-heat dysentery, jaundice, dark urine, stranguria, and edema; it is used for treating burn and scald. Modern researches have shown that rhubarb can remove inflammatory substances in tissues and blood plasma in the body, reduce the level of interleukin and tumor necrosis factor in blood serum and reduce the generation of endotoxin so as to achieve the effects of resisting bacteria and diminishing inflammation.
The Bupleurum is dry root of Bupleurum scorzonerifolium of Umbelliferae or Bupleurum scorzonerifolium. Pungent, bitter and slightly cold. It enters liver, gallbladder and lung meridians. Disperse and dispel heat, soothe liver and relieve depression, and lift yang qi. Can be used for treating common cold with fever, and distending pain in chest and hypochondrium. Studies show that the bupleurum distilled liquid can increase the tolerance of mice to pain, and the bupleurum volatile oil can inhibit ear swelling and capillary permeability of mice caused by dimethylbenzene, so that the bupleurum volatile oil has certain anti-inflammatory and analgesic effects.
Rhizoma Atractylodis is dried rhizome of Atractylodes lancea or Atractylodes lancea in Compositae. Pungent and bitter, warm. It enters spleen, stomach and liver meridians. Dry dampness, invigorate spleen, expel wind, dispel cold, improve eyesight. Can be used for treating damp obstruction of middle energizer, abdominal distention, diarrhea, edema, tinea pedis , rheumatalgia, common cold due to wind-cold, night blindness, and dim eyesight. The research shows that the part of the rhizoma atractylodis volatile oil has obvious influence on the inhibition rate of the body twisting reaction of the mice caused by acetic acid, and the rhizoma atractylodis volatile oil has the effect of inhibiting the auricle swelling of the mice, which shows that the rhizoma atractylodis volatile oil has obvious anti-inflammatory and analgesic effects.
Herba asari is dried root and rhizome of herba asari of Aristolochiaceae, herba asari of Hancheng or herba asari of Hua. Pungent and warm. It enters heart, lung and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, inducing resuscitation, warming lung, and resolving fluid retention. Can be used for treating common cold due to wind-cold, headache, toothache, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, rheumatalgia, phlegm retention, asthma and cough. Researches show that asarum volatile oil has an antipyretic effect on artificial fever caused by warm thorns, vaccines and tetrahydro-beta-naphthylamine after being infused with 0.2-0.5 mL/kg of stomach by rabbits; for a rat fever model caused by yeast suspension, the asarum volatile oil is injected into the abdominal cavity for 0.11mL/kg, and the obvious antipyretic effect is also shown; the volatile oil main component methyl eugenol in asarum can reduce the degree of nasal mucosa gland edema and gland secretion by up-regulating the expression of AQP5, thereby relieving symptoms such as allergic rhinitis, nasal itching, sneeze, watery nasal discharge and the like, and the alpha-asarone has an inhibiting effect on the immune inflammatory reaction of the rat microglial cells induced by lipopolysaccharide.
The fructus evodiae is dry near-ripe fruit of Evodia rutaecarpa (Rutaceae) or Evodia rutaecarpa (Rutaceae). Pungent, bitter and hot; it is slightly toxic. It enters liver, spleen, stomach and kidney meridians. Dispel cold and alleviate pain, descend adverse qi to arrest vomiting, strengthen yang and check diarrhea. Can be used for treating headache due to jueyin, colic due to cold, tinea pedis due to cold dampness, abdominal pain during menstruation, abdominal pain, emesis, acid regurgitation, and diarrhea due to five elements. The modern researches respectively discuss the analgesic effect of the volatile oil and the water extract of the evodia rutaecarpa on mice, and the results show that the volatile oil and the water extract of the evodia rutaecarpa have an antagonistic effect on the torsion reaction of the mice caused by acetic acid, so that the volatile oil of the evodia rutaecarpa has analgesic effect and the correlation of the property and the effect of the volatile oil is reflected.
Notopterygium root, bupleurum root, rhizoma atractylodis, asarum and evodia rutaecarpa are all aromatic traditional Chinese medicines, the 'Shennong herbal Bai Ji' reveals that the action mechanism of aromatic medicines is that the person is fragrant, the healthy qi is strong, the pathogenic factors are removed and the foul is also avoided, and the clear generation Wu Shangxian considers that the action of aromatic volatile oil is mainly that the leading group medicine is capable of removing stagnation and reaching the disease place, so that the disease is not treated as if the disease is caused by qi and blood circulation, and the disease is self-contained. The indications indicate that the aromatic drugs can remove foul smell and disease qi to achieve Kuang Fu positive qi function by clearing healthy qi, and most of the aromatic drugs have the effects of relieving exterior syndrome and eliminating pathogenic factors. Notopterygium root has the effects of relieving exterior syndrome, dispelling cold, dispelling wind-dampness and relieving arthralgia; zhu is good at drying dampness and dispelling wind and cold; asarum herb, herba asari, has the effect of dispelling wind and cold, and is especially effective in relieving pain; radix bupleuri is used for dispelling and reducing fever; evodia rutaecarpa has the effects of dispelling cold and relieving pain; the medicine can be used together to remove pathogenic wind-cold dampness, promote qi and blood circulation, and relieve pain. The large Huang Gongshan has the effects of clearing heat and detoxicating, cooling blood and relieving swelling, and is compatible with the synergistic effect of clearing heat toxin and internal abundance caused by mosquito bites. The medicines are combined together to play the roles of aromatic and dirt-removing, wind-dispelling and itching-relieving, detumescence and pain-relieving. Modern pharmaceutical researches show that volatile oil components in notopterygium root, bupleurum, rhizoma atractylodis, asarum and evodia rutaecarpa in the prescription have antipyretic, analgesic and anti-inflammatory effects, and can play a definite therapeutic role in skin redness, swelling, pain and itching after mosquito bite by matching with rheum officinale for resisting bacteria and diminishing inflammation.
Compared with the prior art, the invention has the beneficial effects.
Notopterygii rhizoma, bupleuri radix, rhizoma Atractylodis, herba asari and fructus evodiae are all aromatic Chinese medicinal materials, and most of the aromatic medicinal materials have effects of relieving exterior syndrome and eliminating pathogenic factors. The medicines are combined together to play the roles of aromatic and dirt-removing, wind-dispelling and itching-relieving, detumescence and pain-relieving. The experimental results of the research show that the invention has an inhibiting effect on the skin itch of mice caused by dextran and has an anti-inflammatory effect on ear swelling of mice caused by dimethylbenzene. Clinical researches show that the invention has good effect on itching and swelling caused by mosquito bites.
Detailed Description
The invention will be better understood from the following examples. However, it will be readily understood by those skilled in the art that the specific material ratios, process conditions and results thereof described in the examples are illustrative of the present invention and should not be construed as limiting the invention described in detail in the claims.
Example 1 preparation of a gel of the medicament of the invention.
1. The traditional Chinese medicine composition for treating mosquito bites is prepared from the following medicinal materials in parts by weight: 1 part of notopterygium root, 1 part of rheum officinale, 1 part of radix bupleuri, 1 part of rhizoma atractylodis, 1 part of asarum and 1 part of fructus evodiae.
2. A method for preparing a Chinese medicinal composition for treating insect bite comprises the following steps.
Step (1): extracting volatile oil: mixing the above materials, pulverizing into coarse particles, soaking in 8 times of pure water for 1 hr, extracting by steam distillation for 4 hr until volatile oil amount is not increased, and collecting the volatile oil in another container.
Step (2): adding deionized water into proper amount of carbomer, stirring, and naturally swelling overnight to obtain carbomer solution with concentration of 0.5%.
Step (3): adding a proper amount of Tween 80 into the solution obtained in the step (2) to prepare a 0.5% carbomer solution containing Tween 80 with the concentration of 2%.
Step (4): and (3) dripping the volatile oil extracted in the step (1) into the solution obtained in the step (3), and stirring until the solution is clear, thereby preparing the solution with the volatile oil concentration of 0.2%.
Step (5): and (3) taking the solution in the step (4), and dripping triethanolamine to adjust the PH value to 7.
Step (6): and (5) filling to obtain the gel of the medicine.
Example 2 preparation of a spray of the medicament of the invention.
Step (1): extracting volatile oil: mixing the above materials, pulverizing into coarse particles, soaking in 8 times of pure water for 1 hr, extracting by steam distillation for 4 hr until volatile oil amount is not increased, and collecting the volatile oil in another container.
Step (2): adding Tween 80 into pure water to obtain solution with Tween 80 concentration of 2%.
Step (3): and (3) dripping the volatile oil extracted in the step (1) into the solution obtained in the step (2), and stirring to prepare a solution containing 0.2% of the volatile oil.
Step (4): taking the solution in the step (3), and dripping NaHCO 3 The pH value of the solution is regulated to 7, and the preparation method is obtained.
Step (5): and (5) filling to obtain the spray of the medicine.
Example 3 an experiment of the inhibition of skin itch in mice caused by dextran by a Chinese medicinal composition for treating mosquito bites.
Experimental animals and groupings: SPF Kunming Mice (KM) are divided into 5 experimental groups of 50 mice, namely a blank control group, a model group, a traditional Chinese medicine gel group and a traditional Chinese medicine spray group, and 10 mice of a certain brand of floral water control group are respectively divided into male and female halves.
The experimental method comprises the following steps: the day before the experiment, the backs of the groups of mice were dehaired with dehairing paste with an area of 2X 2cm 2 On the same day of experiment, model group, chinese medicinal gel group, chinese medicinal spray group, certain brand toilet water control group, each group of mice tail intravenous injection of 0.01% dextran (10 mL/kg), blank group injection of equal volume physiological saline, and after injection, chinese medicinal gel group at dehairing placeUniformly coating traditional Chinese medicine gel, coating traditional Chinese medicine spray group with traditional Chinese medicine spray, coating blank group and model group with normal saline, coating contrast group with floral water, scratching the head with the front paws of mice, scratching the trunk with the rear paws, and biting each part and tail of the body with the mouth as itching reaction indexes. And observing and recording the pruritus times of each group of mice within 30min of each mouse, and carrying out data statistics treatment on the total pruritus duration time to evaluate the antipruritic effect of the drug.
Table 1 the number of times and duration of action of the Chinese medicinal composition on dextran induced skin itch in mice.
。
# Compared to the model set.
Example 4A traditional Chinese medicine gel for treating mosquito bites is an anti-inflammatory experiment for mice ear swelling caused by paraxylene.
Experimental animals and groupings: SPF Kunming Mice (KM) are 40 in total, and each half of the SPF Kunming mice is divided into 4 experimental groups, namely a model group, a traditional Chinese medicine gel group, a traditional Chinese medicine spray group and a certain brand of floral water control group, wherein each group comprises 10 female and male halves.
The experimental method comprises the following steps: the left ear of each group of mice was coated with 0.05mL of xylene to cause inflammation, and the right ear was used as a control. After 30min of inflammation, model group mice are smeared with 0.5mL of physiological saline, 0.5mL of traditional Chinese medicine gel and 0.5mL of traditional Chinese medicine spray respectively, and a certain brand of floral water group mice are smeared with 0.5mL of floral water respectively, and are smeared with the inner and outer parts of the left auricle for 60min, the neck of the mice are dislocation killed, ears are sheared off, round lugs are respectively smeared on the same parts of the left ear and the right ear by a puncher with the diameter of 8mm, the round lugs are weighed, the left ear is used for comparison, the quality difference of the left ear and the right ear is the swelling degree, the swelling degree of each group is calculated, and the swelling inhibition rate is calculated according to a formula. Inhibition = (swelling degree of model group-swelling degree of drug administration group))/swelling degree of model group x 100%.
Table 2 the inhibition rate of the traditional Chinese medicine gel to the ear swelling of mice caused by paraxylene.
。
Example 4A traditional Chinese medicine gel for treating mosquito bites has been observed in curative effect.
Observing an object: 50 cases are collected from 6 months 2021 to 10 months 2022. 30 cases of traditional Chinese medicine gel sets, 17 cases of men and 13 cases of women; the age is 5-60 years.
Inclusion criteria: the clinical symptoms are mainly caused by mosquito and insect bites, local itching is hard, the local itching has a hot pain feeling, and no suppurative infection focus exists.
Exclusion criteria: (1) Patients who have anaphylactic reaction phenomenon to the medicines contained in the gel; (2) suffering from psychotic disorders or presenting with cognitive impairment.
Standard of efficacy: (1) the traditional Chinese medicine disease diagnosis curative effect standard is referred to for preparation. And (3) curing: the skin lesions subsided and the subjective symptoms of itching disappeared. The effect is shown: the symptom of subjective pruritus is obviously relieved, and the skin damage is resolved by more than 60 percent. Improvement: the symptom of subjective pruritus is relieved, and the skin damage is resolved by 30-60%. The method is characterized in that: the symptoms of skin lesions and pruritus are unchanged, or the skin lesions are resolved by less than 30 percent.
The using method comprises the following steps: the gel of the invention is suitable for being uniformly smeared on mosquito bites.
Table 3 shows the observation of the curative effect of the traditional Chinese medicine gel for treating mosquito bites.
。
The gel of the composition has no skin irritation in the test process and no systemic or local adverse reaction.
Typical cases.
Case 1 Guan Mou, female, 39 years old. Before the product is used, symptoms such as swelling, itching and the like can appear at the biting position after the product is bitten by mosquitoes, the person can not grasp the mosquito, and the swelling can gradually subside after two days. The gel is applied to the affected part 10 minutes after the mosquito bites, and the itching symptoms are relieved after 5 minutes, and the symptoms such as red swelling, swelling and the like are resolved within 30 minutes. After the traditional Chinese medicine is bitten by mosquitoes, the traditional Chinese medicine is used for multiple times, and the antipruritic and detumescent effects are obvious.
Case 2 Wang Mou, female, 5 years old. Before the product is used, after the mosquito bites, itching at the bites, swelling and swelling gradually subside after 2 days. After 20 minutes from the bite of the mosquito, the gel is used, the itching is resolved after 3 minutes, and the swelling are resolved after 30 minutes. The traditional Chinese medicine composition is used for multiple times after the traditional Chinese medicine composition is used for removing swelling and relieving itching.
Case 3 Liu Mou, male, 30 years old. Before the product is used, after the mosquito bites, the itching at the bites is difficult to endure, and the itching, swelling and swelling are felt under the scratching condition. After 20 minutes from the bite of the mosquito, the itching symptom is obviously relieved by using the gel, and the itching symptom gradually subsides within 60 minutes. The traditional Chinese medicine composition is used for multiple times after the traditional Chinese medicine composition is used for removing swelling and relieving itching.
Claims (5)
1. The application of the traditional Chinese medicine composition for treating mosquito bites in preparing an external preparation for treating mosquito bites is characterized by comprising the following raw materials in parts by weight: 1-6 parts of notopterygium root, 1-4 parts of rheum officinale, 1-4 parts of radix bupleuri, 1-6 parts of rhizoma atractylodis, 1-6 parts of asarum and 1-4 parts of fructus evodiae.
2. The use of a traditional Chinese medicine composition for treating mosquito bites as claimed in claim 1 in preparing an external preparation for treating mosquito bites, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-4 parts of notopterygium root, 1-2 parts of rheum officinale, 1-2 parts of radix bupleuri, 1-4 parts of rhizoma atractylodis, 1-4 parts of asarum and 1-2 parts of fructus evodiae.
3. The use of a traditional Chinese medicine composition for treating mosquito bites as claimed in claim 1 in preparing an external preparation for treating mosquito bites, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1 part of notopterygium root, 1 part of rheum officinale, 1 part of radix bupleuri, 1 part of rhizoma atractylodis, 1 part of asarum and 1 part of fructus evodiae.
4. A preparation method of a gel of a pharmaceutical composition for treating mosquito bites is characterized by comprising the following steps of
Step (1): extracting volatile oil: accurately weighing Notopterygii rhizoma, radix et rhizoma Rhei, bupleuri radix, rhizoma Atractylodis, herba asari and fructus evodiae according to the weight parts of the traditional Chinese medicine composition in any one of claims 1-3, mixing, pulverizing into coarse particles, soaking in pure water with the weight of 6-10 times of that of the medicinal materials for 0.5-1.5 h, extracting by steam distillation for 4 hours until the volatile oil amount is not increased, and collecting the volatile oil in another container;
step (2): adding deionized water into carbomer, stirring, and naturally swelling overnight to obtain carbomer solution with concentration of 0.5%;
step (3): adding Tween 80 into the solution obtained in the step (2) to prepare a 0.5% carbomer solution containing 2% of Tween 80;
step (4): dripping the volatile oil extracted in the step (1) into the solution obtained in the step (3), and stirring until the solution is clear, so as to prepare a solution with the volatile oil concentration of 0.2%;
step (5): taking the solution in the step (4), and dripping triethanolamine to adjust the pH value to 7;
step (6): and (5) filling to obtain the gel of the medicine.
5. A method for preparing a spray of a pharmaceutical composition for treating mosquito bites, which is characterized by comprising the following steps:
step (1): extracting volatile oil: accurately weighing Notopterygii rhizoma, radix et rhizoma Rhei, bupleuri radix, rhizoma Atractylodis, herba asari and fructus evodiae according to the weight parts of the traditional Chinese medicine composition in any one of claims 1-3, mixing, pulverizing into coarse particles, soaking in pure water with the weight of 6-10 times of that of the medicinal materials for 0.5-1.5 h, extracting by steam distillation for 4 hours until the volatile oil amount is not increased, and collecting the volatile oil in another container;
step (2): adding Tween 80 into pure water to obtain solution containing Tween 80 with concentration of 2%;
step (3): dripping the volatile oil extracted in the step (1) into the solution obtained in the step (2), and stirring to prepare a solution containing 0.2% of the volatile oil;
step (4): taking the solution in the step (3), and dripping NaHCO 3 Regulating the pH value of the solution to 7 to obtain the water-soluble organic compound;
step (5): and (5) filling to obtain the spray of the medicine.
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| CN114452319A (en) * | 2022-03-07 | 2022-05-10 | 安徽华馨生物科技有限公司 | A Chinese medicinal gel for preventing and treating mosquito bite, and its preparation method |
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| CN1698739A (en) * | 2005-04-16 | 2005-11-23 | 刘希山 | Externally applied Chinese medicine preparation for treating skin disease and its preparation method |
| CN101491575A (en) * | 2008-12-18 | 2009-07-29 | 浙江省中医院 | Traditional Chinese medicine extract for treating atopic dermatitis and granules thereof |
| CN103655779A (en) * | 2013-12-27 | 2014-03-26 | 耿丽 | Pharmaceutical composition for treating mosquito and insect bite |
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