CN111920866A - Preparation method and application of traditional Chinese medicine gel for preventing and treating allergic rhinitis - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method and application of a traditional Chinese medicine gel for preventing and treating allergic rhinitis. The gel comprises herba Menthae, herba Artemisiae Annuae, folium Artemisiae Argyi, radix Arnebiae, nidus Vespae and cortex Phellodendri as main active ingredients. The traditional Chinese medicine is extracted by adopting sesame oil, so that the effective ingredients of the traditional Chinese medicine in the prescription can be completely extracted, the problems of low extraction rate and large loss of volatile oil and fat-soluble ingredients of the effective ingredients and excessive sugar, protein and the like of impurity ingredients in the traditional Chinese medicine in the extraction process of the traditional method are solved, the content of the effective ingredients of the product is high, and the content of impurities is low; the gel is prepared by directly adding other auxiliary materials on the basis of the extract of the sesame oil as a solvent, has good affinity with the nasal cavity, can effectively isolate allergens, has the functions of dredging orifices and inhibiting bacteria and fungi in the nasal cavity, and has the functions of preventing allergic rhinitis and improving nasal cavity ventilation.

Description

Preparation method and application of traditional Chinese medicine gel for preventing and treating allergic rhinitis

Technical Field

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method and application of a traditional Chinese medicine gel for preventing and treating allergic rhinitis.

Background

Allergic rhinitis occurs in association with various factors such as heredity, environment, diet, etc., and the conventional treatment methods include improvement of nasal symptoms by antihistamine drugs, desensitization treatment of allergens, and cleansing by nasal cavity cleansing agents.

The most common treatment of rhinitis in western medicine is the use of antihistamines, antiallergic drugs, desensitization therapy and nasal wash. The methods have certain defects, such as certain side effects of using the antihistamine antiallergic drugs to treat allergic rhinitis, dependence after long-term use, easier drying of nasal cavities, short duration and long-term use requirement; the allergen desensitization treatment for allergic rhinitis requires accurate allergen detection and desensitization treatment, the treatment period is long, patients suffering from allergic rhinitis are often allergic to various allergens and are difficult to treat thoroughly, the contact between the allergens and nasal mucosa can be reduced by using a nasal cavity cleaning agent to clean nasal cavities, the prevention effect is achieved, the maintenance time is short, the long-term treatment is required, and the patient acceptance is poor.

The traditional Chinese medicine for treating rhinitis and allergic rhinitis has a long history, and is mainly prepared from flos magnoliae, siberian cocklebur fruit, clematis root, centipeda minima and the like. More flos Magnoliae is used for dispelling wind and cold, relieving stuffy nose and dispelling wind and dampness. Can be used for treating headache due to wind-cold evil, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, wind and cerebral pruritus, and spasm due to damp arthralgia, and fructus Xanthii has effects of dispelling pathogenic wind-cold, dredging nasal orifice, and dispelling pathogenic wind and dampness. The Chinese medicinal composition is used for treating cold headache, nasal obstruction, rhinorrhea, allergic rhinitis, nasosinusitis, wind-cold pruritus and damp arthralgia and contracture, is frequently used for treating rhinitis in traditional Chinese medicines and modern Chinese patent medicines, is mainly used in dosage forms of spray and oral tablets, has a certain treatment effect, and is less used for treating and preventing allergic rhinitis.

The traditional Chinese medicinal materials for treating chronic rhinitis are not adopted, but the medicinal materials with the functions of dispelling wind, dredging orifices, resisting inflammation and resisting allergy are optimally combined, the effective components of the medicinal materials are extracted by sesame oil to prepare gel, and the gel can play the roles of isolating allergen, improving allergic symptoms of nasal cavities and improving ventilation effect after being applied to the nasal cavities.

The invention comprises the following Chinese medicinal materials:

the herba Menthae is traditional Chinese medicine, and is dry aerial part of Mentha haplocalyx Briq. of Labiatae for dispelling wind heat, refreshing mind, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Can be used for treating wind-heat type common cold, early stage of wind-warm syndrome, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, and chest and hypochondrium swelling, and has volatile oil as main effective component, and can be frequently used in Chinese patent medicine or used occasionally in nasal cavity. .

The folium Artemisiae Argyi product is dried leaf of Artemisia argyi LevL.et Vant. The main functions are warming channel and stopping bleeding, dispelling cold and relieving pain; externally used for eliminating dampness and relieving itching. Can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, fetal leakage, lower blood, lower abdomen psychroalgia, menoxenia, and infertility due to cold womb; it can be used for treating skin pruritus. Vinegar moxa charcoal can warm meridians and stop bleeding, and is indicated for bleeding due to deficiency-cold. Its application method includes moxibustion and fumigation. Modern pharmacological studies prove that the folium artemisiae argyi contains various effective components such as volatile oil, flavone and the like, has the effects of resisting bacteria, viruses, bleeding and coagulation, tumors, allergy, free radicals and the like, and the folium artemisiae argyi extract is widely used in products such as medicines, health-care products, cosmetics and the like. The main components of the folium artemisiae argyi are volatile oil, flavone and other water-insoluble components, the traditional products mostly use the medicinal materials or water extracts directly, and the extracts of the effective components are incomplete or lose a great amount in the extraction process.

The herba Artemisiae Annuae is herb of Artemisia of Compositae (its scientific name: Artemisia carvifolia Buch. -ham. ex Roxb. Hort. Beng.), and has effects of clearing heat, cooling blood, removing toxic substance, relieving summer-heat, dispelling pathogenic wind, and relieving itching. The sweet wormwood herb is different from sweet wormwood herb (Artemisia annua L) collected in Chinese pharmacopoeia.

Radix Arnebiae is dry root of Arnebia euchroma (Royle) Johnst. or Arraa Guttata Bunge of Sinkiang Arnebia euchroma (Royle) of Boraginaceae. The main functions are clearing heat and cooling blood, promoting blood circulation and removing toxicity, promoting eruption and removing ecchymoses. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to hot water and fire. The application method comprises topical decocting paste or soaking in vegetable oil and applying. According to modern pharmacological research, the lithospermum extract has multiple functions of resisting inflammation, easing pain, resisting bacteria, resisting virus, resisting tumor, regulating immunity, resisting fertility, protecting liver, stopping bleeding and the like. The lithospermum contains various chemical components such as naphthoquinones, phenolic ketones, phenolic acids, alkaloids, triterpenic acids, flavonoids, lithospermum polysaccharides and the like, and the liposoluble naphthoquinone compound is one of the main bioactive components of the lithospermum. The traditional product is lithospermum ointment or compound lithospermum ointment, the using method is high-temperature frying extraction, the extraction proportion is low, the damage of active ingredients at high temperature is large, most of lithospermum extracts in the market are water extracts or ethanol extracts, and the extraction rate of the active ingredients is low.

The nidus Vespae is nest of Wasp family insect, hornet Polistes olivaceous (DeGeer), Japanese hornet Polistes japonica Thunb, or Heteroclita varia Fabricius. The main functions are counteracting toxic pathogen and killing parasites, and dispelling wind and relieving pain. Can be used for treating pyocutaneous disease, toxic swelling, acute mastitis, scrofula, intractable tinea, fungal infection of hand and foot, toothache, and rheumatalgia.

Cortex Phellodendri is dried bark of Phellodendron chinense Schneid of Rutaceae. The main functions are clearing heat and drying dampness, purging fire and removing steam, detoxifying and treating sore. Can be used for treating dysentery due to damp-heat, jaundice, dark urine, leukorrhagia, pudendal pruritus, pyretic stranguria, odynuria, tinea pedis, , bone-steaming, overstrain, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, eczema, and eczema. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

Disclosure of Invention

The invention provides a traditional Chinese medicine gel for preventing and treating allergic rhinitis, which comprises the following main effective components: the weight ratio is as follows: 1.0-2.0 mint (Mentha haplocalyx Briq.), 3.0-4.0 sweet wormwood (Artemisia carvifolia Buch. -ham. ex Roxb. Hort. Beng.), 3.0-4.0 folium Artemisiae Argyi (Artemisia argyi LevL. et Vant.), 3.0-4.0 radix Arnebiae (Araa Guttata Bunge.), 3.0-4.0 nidus Vespae (nidus Vespae) 1.0-2.0, and 1.0-2.0 cortex Phellodendri (Phellodendron chinense Schneid.).

The invention also aims to provide application of the traditional Chinese medicine gel in preparing a medicine for treating or preventing allergic rhinitis.

In order to achieve the purpose, the invention adopts the following technical measures:

the invention idea is as follows: the invention aims to overcome the defects that in the prior art, the traditional Chinese medicine for preventing and treating allergic rhinitis has a single formula and adopts multiple traditional Chinese medicines: the Chinese medicinal materials of the folium artemisiae argyi, the sweet wormwood herb, the lithospermum, the honeycomb and the like are combined to play a synergistic effect; the sesame oil is adopted for extraction, so that the effective ingredients of the traditional Chinese medicinal materials in the prescription can be completely extracted, the problems of low extraction rate and large loss of volatile oil and fat-soluble ingredients of the effective ingredients and excessive sugar, protein and the like of impurity ingredients in the traditional Chinese medicine in the traditional method extraction process are solved, and the product has high content of the effective ingredients and low content of impurities; the gel is prepared by directly adding other auxiliary materials on the basis of the extract of the sesame oil as a solvent, has good affinity with the nasal cavity, can effectively isolate allergens and improve nasal symptoms, and has simple process.

A gel for preventing and treating allergic rhinitis is prepared by the following method:

the gel comprises the following main effective components in parts by weight: 1.0-2.0 mint (Mentha haplocalyx Briq.), 3.0-4.0 sweet wormwood (Artemisia carvifolia Buch. -ham. ex Roxb. Hort. Beng.), 3.0-4.0 folium Artemisiae Argyi (Artemisia argyi LevL. et Vant.), 3.0-4.0 radix Arnebiae (Araa Guttata Bunge.), 3.0-4.0 nidus Vespae (nidus Vespae) 1.0-2.0, and 1.0-2.0 cortex Phellodendri (Phellodenron chinensis Schneid.);

the herba Menthae is dried aerial part of Mentha haplocalyx Briq. of Labiatae;

the folium Artemisiae Argyi product is dried leaf of Artemisia argyi LevL.et Vant of Compositae;

the herba Artemisiae Annuae is dried aerial part of Artemisia carvifolia Buch-ham.ex Roxb.Hort.Beng of Compositae;

radix Arnebiae is dry root of Arnebia euchroma (Royle) Johnst or arnica Guttata Bunge of Arnebia euchroma (Royle) of Boraginaceae;

the nidus Vespae is nest of Vespidae insect Petasites Polistes olivaceae (DeGeer), Petasites japonicus Polistes japonica Saussure or Petasites hybridus Parasolybia varius Fabricius;

cortex Phellodendri is dried bark of Phellodendron chinense Schneid of Rutaceae.

Step 1: removing impurities and dust from herba Menthae, herba Artemisiae Annuae, folium Artemisiae Argyi, radix Arnebiae, nidus Vespae, and cortex Phellodendri, and adding into a Chinese medicinal extraction tank.

Step 2: adding medicinal sesame oil with the weight 3-3.5 times of the total weight of the traditional Chinese medicinal materials in the step (1) into an extraction tank, and stirring to uniformly mix the medicinal materials and the solvent;

and step 3: heating the extraction tank to 80-90 deg.C, standing for 4-6 hr, filtering, and collecting extract.

And 4, step 4: adding medicinal sesame oil which is 2.5-3 times of the total weight of the traditional Chinese medicinal materials in the step 1 into an extraction tank, and stirring to uniformly mix the medicinal materials and the solvent; heating to 80-90 deg.C, standing for 4-6 hr, filtering, collecting extract, and mixing the extracts of step 3 and step 4;

and 5: adding the extract obtained in the step (4) into a mixing tank, adding sodium polyethylene, beeswax, fumed silica, bentonite, methyl hydroxybenzoate and propyl hydroxybenzoate into the extract, heating to 80-90 deg.C, stirring to completely swell uniformly, and homogenizing at 3000-5000 r/min for 20-30 min; naturally cooling to obtain the final product.

Wherein the weight parts of the extract, the sodium polyethylene, the beeswax, the fumed silica, the bentonite, the methylparaben and the propylparaben are respectively 92-94, 2-3, 1-1.5, 0.05-0.1 and 0.1-0.2.

The application of the gel prepared by the method comprises the application of the gel in preparing a medicament for treating allergic rhinitis or improving the symptoms of allergic rhinitis.

The other raw materials and auxiliary materials used in the invention are common pharmaceutic adjuvant or the equipment is common extraction and concentration equipment and ointment preparation equipment. The extraction method of the active ingredients of the invention uses sesame oil as a solvent and adopts a common extraction and filtration process; the gel preparation process is a common process and will be known to those skilled in the art.

Compared with the prior art, the invention has the following advantages:

the traditional Chinese medicine composition is prepared by combining the traditional Chinese medicine with the effects of preventing and treating rhinitis and the traditional Chinese medicine with the effects of dredging orifices, resisting inflammation, resisting allergy, resisting bacteria and viruses, adopting an optimal extraction solvent and process, simultaneously extracting volatile oil and other various fat-soluble components by using sesame oil, and easily preparing a gel preparation, wherein the content of the active components is high, the loss is less, and the content of other impurities such as polysaccharide, protein and other impurity components is low.

The auxiliary materials of the sesame oil and the gel matrix can play a role in moistening and relieving nasal dryness in nasal cavities, and the formed film is attached to nasal mucosa to isolate allergens in the air for a long time.

The gel prepared by adding the traditional Chinese medicine extract and the auxiliary materials has the advantages of simple process, good affinity of the prepared product with the nasal cavity, long retention time of the nasal cavity, high effect of isolating allergen, improvement of nasal cavity symptoms, antibacterial effect and alleviation of nasal cavity allergy symptoms. The main auxiliary material of the product is sesame oil, so that the product has good stability and remarkable effect.

Detailed Description

In order to make those skilled in the art better understand the technical solution of the present invention, the following detailed description will be made on the technical solution of the present invention with reference to specific embodiments, in the embodiments of the present invention, a traditional Chinese medicine extracting and concentrating apparatus: TN50, emulsifying pan: YH-5L; the remainder are not specified in detail and are conventional reagents or procedures in the art. The lithospermum used in the embodiment of the invention is lithospermum rimonae, and the honeycomb used is a wasp honeycomb.

Example 1:

and (3) a to-be-detected product:

a gel for preventing and treating allergic rhinitis is prepared by the following method:

the gel comprises the following main effective components in parts by weight: mint (mint ha halopthalyx Briq.)2.0, Artemisia annua (Artemisia carvifolia Buch. -ham. ex Roxb. Hort. Beng.), 4.0, Artemisia argyi Levl. et Vant.)4.0, Lithospermum erythrorhizon (Araa Gutta Bunge)4.0, nidus Vespae (Polistes olivaceous (DeGeer) Honeycomb) 2.0, and Phellodendri cortex (Phellodenron chinensis Schneid.) 2.0.

Step 1: removing impurities and dust from herba Menthae, herba Artemisiae Annuae, folium Artemisiae Argyi, radix Arnebiae, nidus Vespae, and cortex Phellodendri, and adding into a Chinese medicinal extraction tank.

Step 2: adding medicinal sesame oil with the weight 3 times of the total weight of the traditional Chinese medicinal materials in the step 1 into an extraction tank, and stirring for 2 minutes at 30 revolutions per minute to uniformly mix the traditional Chinese medicinal materials with the solvent.

And step 3: heating the extraction tank to 90 deg.C, standing for 4 hr, filtering, and collecting extract.

And 4, step 4: adding medicinal sesame oil with the weight 2.5 times of the total weight of the traditional Chinese medicinal materials in the step (1) into an extraction tank, stirring at 30 r/min, continuously standing and extracting for 4 hours at 90 ℃, filtering, collecting the extract, and combining the extracts in the step (3) and the step (4);

and 5: adding the extract obtained in the step (4) into a mixing tank, adding sodium polyethylene, beeswax, fumed silica, bentonite, methyl hydroxybenzoate and propyl hydroxybenzoate into the extract, heating to 90 ℃, stirring at 60 r/min for about 120 minutes until the mixture is completely and uniformly swelled, homogenizing at 5000 r/min for 30 minutes, and naturally cooling to obtain the product;

wherein the weight parts of the extract, the sodium polyethylene, the beewax, the fumed silica, the bentonite, the methylparaben and the propylparaben are respectively 92, 3.0, 1, 0.1 and 0.2.

Control 1: only Artemisia annua (Artemisia annua L.) recorded in the Chinese pharmacopoeia is replaced by Artemisia annua (Artemisia annua L.) in the main effective component of the product to be tested, and the rest content and the preparation method are unchanged, so that whether the components are simply replaced can be tested to obtain the treatment effect of the traditional Chinese medicine gel.

Control 2:

and (3) adding hydroxypropyl methyl ester and propyl hydroxybenzoate into the extract prepared in the 4 th step in the preparation process of the to-be-detected product to examine the influence of different dosage forms on the drug effect, wherein the weight ratio of the extract, the methyl hydroxybenzoate and the propyl hydroxybenzoate is 92, 0.1 and 0.2 in sequence.

Control 3:

only the sesame oil serving as the extraction solvent in the preparation process of the product to be detected is changed into water, and preservatives hydroxypropyl methyl ester and propyl hydroxybenzoate are added, wherein the weight ratio of the extract to the methyl hydroxybenzoate to the propyl hydroxybenzoate is 92, 0.1 and 0.2 in sequence. No gel was prepared to examine the effect of different extraction solvents on drug efficacy.

The experimental scheme is as follows: a certain number of volunteers aged 6-50 years are selected, and the symptoms are sneezing, rhinorrhea and nasal obstruction, and the patients with allergic rhinitis are clinically diagnosed. Randomly grouping the volunteers into 1-4 groups, and testing the to-be-tested sample and the reference sample 1-3 for 20 persons in each group.

The test method comprises the following steps: the preparation is applied to nasal cavity of patient uniformly, and the dosage is about 0.01g per nostril, 3 times per day, and the application lasts for 14 days.

Observation indexes are as follows: after application, nasal cavity ventilation effect, sneezing condition and rhinorrhea condition were observed, and after 14 days of continuous application, the patient was stopped, and the recurrence time after stopping application was observed.

Group 1: using the article to be tested

To summarize: a total of 20 volunteers in the test sample group were used, with the age distribution ranging from 6 to 42 years. As a result, 20% of the symptoms were relieved, and 80% of the symptoms of sneezing were completely disappeared; the symptoms of running nasal mucus disappeared in 100% of volunteers; 10% of nasal obstruction symptoms are relieved, and 90% of nasal obstruction symptoms completely disappear. The weight of each symptom is calculated according to 33.3%, and the total effective rate is 100%. After the application is stopped, the protection time is 11 days at most and 6 days at least.

Group 2: use of control 1

To summarize: a total of 20 volunteers in the test sample group were used, with the age distribution ranging from 8 to 42 years. As a result, 30% of the symptoms were relieved, and 70% of the symptoms of sneezing were completely disappeared; the symptoms of running nasal mucus are reduced in 25 percent, and the symptoms of running nasal mucus disappear in 75 percent of volunteers; 30% of nasal obstruction symptoms are relieved, and 70% of nasal obstruction symptoms disappear. The weight of each symptom is calculated according to 33.3%, and the total effective rate is 100%. After the application is stopped, the protection time is 7 days at most and 2 days at least.

Group 3: use of control 2

To summarize: a total of 20 volunteers from the test sample group were used, with the age distribution ranging from 7 to 32 years. As a result, 50% of the symptoms were relieved, and 40% of the symptoms of sneezing were completely disappeared; the symptoms of running nasal mucus are reduced in 81 percent, and the symptoms of running nasal mucus disappear in 19 percent of volunteers; 65% of nasal obstruction symptoms are relieved, and 35% of nasal obstruction symptoms disappear. The weight of each symptom is calculated according to 33.3%, and the total effective rate is 96.3%. After the application is stopped, the protection time is 8 days at most and 4 days at least.

Group 4: use control 3

To summarize: a total of 20 volunteers from the test sample group were used, with the age distribution ranging from 7 to 40 years. As a result, 85% of symptoms were relieved, and 15% of symptoms of sneezing were completely disappeared; 80% of symptoms of runny nose are relieved; 100% of nasal congestion symptoms were reduced. The total effective rate is 92.0%. After the application is stopped, the protection time is 3 days at most and 1 day at least.

Example 2:

a gel for preventing and treating allergic rhinitis is prepared by the following method:

the gel comprises the following main effective components in parts by weight: mint (mint ha halopthalyx Briq.)1.0, Artemisia annua (Artemisia carvifolia Buch. -ham. ex Roxb. Hort. Beng.), 3.0, Artemisia argyi Levl. et Vant.)3.0, Lithospermum erythrorhizon (Araa Gutta Bunge)3.0, nidus Vespae (Polistes olivaceous (DeGeer)1.0, and Phellodendri cortex (Phellodenron chinensis Schneid.) 1.0.

The preparation steps and parameters are the same as those of the sample to be tested in example 1, and the using method is the same as that in example 1.

And (3) test results: the allergic rhinitis symptoms after 20 people use are shown in the following table:

to summarize: a total of 20 volunteers in the test sample group were used, with the age distribution ranging from 8 to 42 years. As a result, 30% of the symptoms were relieved, and 70% of the symptoms of sneezing were completely disappeared; the symptoms of runny nose are reduced by 20 percent, and the symptoms of runny nose disappear by 80 percent of volunteers; 15% of nasal obstruction symptoms are relieved, and 85% of nasal obstruction symptoms disappear. The total effective rate is 100%. After the application is stopped, the protection time is 9 days at most and 5 days at least.

Example 3:

a gel for preventing and treating allergic rhinitis is prepared by the following method:

the gel comprises the following main effective components in parts by weight: mint (mint ha halopthalyx Briq.)2.0, Artemisia annua (Artemisia carvifolia Buch. -ham. ex Roxb. Hort. Beng.), 3.5, Artemisia argyi Levl. et Vant.)3.5, Lithospermum erythrorhizon (Araa Gutta Bunge)3.5, nidus Vespae (Polistes olivaceous (DeGeer)1.5, and Phellodendri cortex (Phellodenron chinensis Schneid.) 1.5.

In the preparation process, the weight parts of the extract, the sodium polyethylene, the beeswax, the fumed silica, the bentonite, the methyl hydroxybenzoate and the propyl hydroxybenzoate in the step 5 are 92, 2.0, 1.0, 0.1 and 0.2.

The rest preparation steps and parameters are the same as those of the preparation steps of the sample to be tested in the example 1, and the using method is the same as that in the example 1.

The preparation steps and parameters are the same as those of the preparation step of the sample to be tested in example 1, and the using method is the same as that in example 1

And (3) test results: the allergic rhinitis symptoms after 20 people use are shown in the following table:

to summarize: a total of 20 volunteers from the test sample group were used, with the age distribution ranging from 7 to 45 years. As a result, 35% of the symptoms were relieved, and 65% of the symptoms of sneezing were completely disappeared; the 35% rhinorrhea symptom is relieved, and the 65% volunteers have no rhinorrhea symptom; 25% of nasal obstruction symptoms are relieved, and 75% of nasal obstruction symptoms disappear. The total effective rate is 100 percent. After the application is stopped, the protection time is 8 days at most and 5 days at least.

The results of examples illustrate that the Chinese medicinal gel for preventing allergic rhinitis according to the present invention has an effect of improving allergic symptoms in nasal cavity in combination with the Chinese medicinal extracts, and the effect of improving allergic symptoms becomes poor by replacing the components thereof. The preparation form of the nasal spray is oily matrix gel, has good affinity with nasal cavity and longer duration, can play a role in blocking allergen for a longer time, and the water extract or oil extract with the same prescription is directly applied to the nasal cavity, has shorter duration and poorer allergen isolation effect.

The embodiments of the present invention have been described in detail, but the description is only for the preferred embodiments of the present invention and is not intended to limit the present invention. Any modification, equivalent replacement, and improvement made within the scope of the application of the present invention should be included in the protection scope of the present invention.

Claims (3)

1. A gel for preventing and treating allergic rhinitis is prepared by the following method:

the gel comprises the following main effective components in parts by weight: mint (A), (B)Mentha haplocalyx Briq.)1.0-2.0, herba Artemisiae Annuae (Artemisia carvifolia Buch-ham. ex Roxb. Hort. Beng.)3.0-4.0, and folium Artemisiae Argyi (folium Artemisiae Argyi: (folium Artemisiae Argyi)Artemisia argyi LevL.et Vant.)3.0-4.0, radix Arnebiae (Arraa Guttata Bunge)3.0-4.0, nidus Vespae 1.0-2.0, and cortex Phellodendri (Phellodenron chinensis Schneid.) 1.0-2.0;

step 1: removing impurities and dust from herba Menthae, herba Artemisiae Annuae, folium Artemisiae Argyi, radix Arnebiae, nidus Vespae and cortex Phellodendri, and adding into a Chinese medicinal extraction tank;

step 2: adding medicinal sesame oil with the weight 3-3.5 times of the total weight of the traditional Chinese medicinal materials in the step (1) into an extraction tank, and stirring to uniformly mix the medicinal materials and the solvent;

and step 3: heating the extraction tank to 80-90 deg.C, standing for 4-6 hr, filtering, and collecting extract;

and 4, step 4: adding medicinal sesame oil which is 2.5-3 times of the total weight of the traditional Chinese medicinal materials in the step 1 into an extraction tank, and stirring to uniformly mix the medicinal materials and the solvent; heating to 80-90 deg.C, standing for 4-6 hr, filtering, collecting extract, and mixing the extracts of step 3 and step 4;

and 5: adding the extract obtained in the step (4) into a mixing tank, adding sodium polyethylene, beeswax, fumed silica, bentonite, methyl hydroxybenzoate and propyl hydroxybenzoate into the extract, heating to 80-90 deg.C, stirring to completely swell uniformly, and homogenizing at 3000-5000 r/min for 20-30 min; naturally cooling to obtain the final product;

wherein the weight parts of the extract, the sodium polyethylene, the beeswax, the fumed silica, the bentonite, the methylparaben and the propylparaben are respectively 92-94, 2-3, 1-1.5, 0.05-0.1 and 0.1-0.2.

2. Use of the gel of claim 1 for the preparation of a medicament for treating or preventing allergic rhinitis.

3. Use of the gel of claim 1 for the preparation of a medicament for ameliorating the symptoms of allergic rhinitis.