CN111067971A - Traditional Chinese medicine composition for treating paronychia and using method thereof - Google Patents
Traditional Chinese medicine composition for treating paronychia and using method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating paronychia and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 0.1-1 part of hemp extract, 3-10 parts of cactus, 5-15 parts of green tea extract, 8-20 parts of coptis extract and 0.5-1 part of cinnamon extract; the application method comprises mixing the extract of Cannabis sativa, the extract of green tea, the extract of Coptidis rhizoma, and the extract of Cinnamomi corex to obtain unguent; removing thorns from fresh radix et caulis Opuntiae Dillenii, mashing into paste, squeezing, adding into the paste, stirring and mixing to obtain Chinese medicinal paste; the affected part is sterilized by conventional method, applied with the Chinese medicinal ointment, covered or bandaged with gauze, and changed 1 time per day. The traditional Chinese medicine composition has scientific compatibility, simple use, quick curative effect and short treatment course; the comprehensive effects of the traditional Chinese medicines are adopted to treat mycosis and aseptic inflammation, no toxic or side effect is caused, and no damage is caused to skin.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating paronychia and a using method thereof.
Background
Paronychia refers to a suppurative infection of soft tissues around the nail, and is caused by the growth and reproduction of bacteria which invade the skin under the skin through the minimally invasive lesions of the paraungual skin. Paronychia and onychomycosis can not be cured by self, and suppuration can occur after a long time. Failure to treat the nail for a long period of time can cause severe deformity, resulting in nail bed destruction, and ultimately nail defects, and even loss of nails in severe cases. At present, most of treatment methods for paronychia require nail-removal operation in a hospital, a nail bed is exposed after nail-removal, nursing is inconvenient, a new nail grows for 36 months again, the possibility of reoccurrence of the paronychia cannot be avoided after the new nail is generated, generally, the whole nail or toenail needs to be removed, so that the paronychia can be better cured, but the treatment method causes great pain to a patient, and tissues attached to the nail or toenail are easily infected due to the lack of nail or toenail protection in the recovery process of the patient.
Although the diagnosis and treatment of the paronychia are improved at present, and related research is deepened day by day, the paronychia is still a chronic disease in clinical treatment and still has the characteristics of high morbidity and high recurrence rate, so that the pain of patients and the trouble of doctors are increased, and the problem cannot be fundamentally solved.
Disclosure of Invention
The invention aims to overcome the defects and provides a traditional Chinese medicine composition for treating paronychia, which has a good treatment effect and no side effect, and a using method thereof.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition for treating paronychia comprises the following raw materials in parts by weight: 0.1-1 part of hemp extract, 3-10 parts of cactus, 5-15 parts of green tea extract, 8-20 parts of coptis extract and 0.5-1 part of cinnamon extract.
Preferably, the traditional Chinese medicine composition for treating paronychia comprises the following raw materials in parts by weight: 0.5 part of hemp extract, 5 parts of cactus, 8 parts of green tea extract, 9 parts of coptis extract and 0.5 part of cinnamon extract.
Preferably, the content of cannabidiol in the cannabis leaf extract is > 50%, and the content of tetrahydrocannabinol is < 0.3%.
Preferably, the content of tea polyphenol in the green tea extract is more than or equal to 80 percent, and the content of berberine hydrochloride in the green tea extract is more than or equal to 10 percent.
Preferably, the content of cinnamon polyphenol in the cinnamon extract is more than or equal to 30%.
The medicinal principle of each component in the traditional Chinese medicine composition is as follows:
cannabis leaf extract: a general name of cannabinoid and terpenoid extracted from industrial cannabis is obtained by separation and purification. The cannabidiol which is the main active component in the cannabis leaf extract has good effects of sterilization, inflammation diminishing, itching relieving and pain relieving, and has broad-spectrum sterilization capability on various bacteria and fungi.
Cactus: has effects in promoting qi and blood circulations, clearing away heat and toxic materials, cooling blood, stopping bleeding, clearing lung-heat, and relieving cough.
Green tea: has the effects of scavenging free radicals, resisting oxidation, inhibiting bacteria, relieving inflammation, inhibiting tumor, and absorbing ultraviolet.
Coptis chinensis: bitter in property and cold in nature. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. The functions are as follows: clear heat and dry dampness, purge fire and remove toxicity. Has antibacterial effect on various gram positive and negative bacteria in vitro, wherein the antibacterial effect on hemolytic streptococcus, Staphylococcus aureus, Vibrio cholerae and Streptococcus type B is strong, and the antibacterial effect on Escherichia coli and Salmonella typhi is weak.
Cinnamon: pungent, sweet and big heat. It enters kidney, spleen, heart and liver meridians. Has effects in tonifying fire, supporting yang, inducing fire, dispelling cold, relieving pain, promoting blood circulation, and dredging collaterals, and can be used for treating sexual impotence, cold womb, lumbago, knee psychroalgia, asthma due to kidney deficiency, yang deficiency giddiness, conjunctival congestion pharyngalgia, cold pain of heart and abdomen, deficiency cold vomiting and diarrhea, cold hernia, galloping, amenorrhea, and dysmenorrhea.
The invention also aims to provide a using method of the traditional Chinese medicine composition for treating paronychia, which comprises the following steps:
(1) weighing hemp extract, green tea extract, coptis extract and cinnamon extract according to the weight parts, and uniformly mixing;
(2) removing thorns from fresh cactus, pounding into paste, squeezing, adding into the ointment obtained in step (1), and stirring and mixing uniformly to obtain traditional Chinese medicine ointment;
(3) and (3) the affected part is disinfected conventionally, then the traditional Chinese medicine ointment in the step (2) is applied, and the affected part is covered or bandaged by gauze and is replaced 1 time every day.
Compared with the prior art, the invention has the beneficial effects that:
(1) the traditional Chinese medicine composition for treating paronychia consists of a hemp extract, cactus, a green tea extract, a coptis extract and a cinnamon extract, wherein cannabidiol contained in the hemp extract has the functions of diminishing inflammation and easing pain; the Coptidis rhizoma extract has effects of clearing away heat and toxic materials; radix et caulis Opuntiae Dillenii has effects in removing necrotic tissue and promoting granulation; the green tea extract has antibacterial and antioxidant effects; the cinnamon extract can promote blood circulation and promote menstruation; the traditional Chinese medicines interact with each other, and have the effects of sterilizing or inhibiting various suppurative bacteria; simultaneously, the composition has antiseptic and antipyretic effects, can reduce permeability of capillary vessel, dilate blood vessel, reduce blood vessel pressure, reduce exudation, relieve and prevent tissue degeneration and necrosis, shorten and relieve the sustained action of pathogenic factors and the stimulation of metabolite, and prevent and eliminate hyperplasia; the added cannabis extract also has analgesic effect, and can relieve pain caused by irritation of inflammatory mediators such as nerve ending and metabolite, vasoactive amine, and skin irritation due to inflammatory exudate compression.
(2) When the Chinese medicinal composition is used, the fresh cactus is despun, smashed and squeezed to obtain juice, and then is mixed with other Chinese medicinal extracts, so that the capability of killing fungi can be improved to the maximum extent.
(3) The traditional Chinese medicine composition has scientific compatibility, simple use, quick curative effect and short treatment course. The comprehensive effects of the traditional Chinese medicines are adopted to treat mycosis and aseptic inflammation, no toxic or side effect is caused, and no damage is caused to skin.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
A traditional Chinese medicine composition for treating paronychia comprises the following raw materials in parts by weight: 0.1-1 part of hemp extract, 3-10 parts of cactus, 5-15 parts of green tea extract, 8-20 parts of coptis extract and 0.5 part of cinnamon extract.
A using method of a traditional Chinese medicine composition for treating paronychia comprises the following steps:
(1) weighing hemp extract, green tea extract, coptis extract and cinnamon extract according to the weight parts, and uniformly mixing;
(2) removing thorns from fresh cactus, pounding into paste, squeezing, adding into the ointment obtained in step (1), and stirring and mixing uniformly to obtain traditional Chinese medicine ointment;
(3) and (3) the affected part is disinfected conventionally, then the traditional Chinese medicine ointment in the step (2) is applied, and the affected part is covered or bandaged by gauze and is replaced 1 time every day.
Example 2
A traditional Chinese medicine composition for treating paronychia comprises the following raw materials in parts by weight: 0.1-1 part of hemp extract, 3-10 parts of cactus, 5-15 parts of green tea extract, 8-20 parts of coptis extract and 0.8 part of cinnamon extract.
A using method of a traditional Chinese medicine composition for treating paronychia comprises the following steps:
(1) weighing hemp extract, green tea extract, coptis extract and cinnamon extract according to the weight parts, and uniformly mixing;
(2) removing thorns from fresh cactus, pounding into paste, squeezing, adding into the ointment obtained in step (1), and stirring and mixing uniformly to obtain traditional Chinese medicine ointment;
(3) and (3) the affected part is disinfected conventionally, then the traditional Chinese medicine ointment in the step (2) is applied, and the affected part is covered or bandaged by gauze and is replaced 1 time every day.
Example 3
A traditional Chinese medicine composition for treating paronychia comprises the following raw materials in parts by weight: 0.1-1 part of hemp extract, 3-10 parts of cactus, 5-15 parts of green tea extract, 8-20 parts of coptis extract and 1 part of cinnamon extract.
A using method of a traditional Chinese medicine composition for treating paronychia comprises the following steps:
(1) weighing hemp extract, green tea extract, coptis extract and cinnamon extract according to the weight parts, and uniformly mixing;
(2) removing thorns from fresh cactus, pounding into paste, squeezing, adding into the ointment obtained in step (1), and stirring and mixing uniformly to obtain traditional Chinese medicine ointment;
(3) and (3) the affected part is disinfected conventionally, then the traditional Chinese medicine ointment in the step (2) is applied, and the affected part is covered or bandaged by gauze and is replaced 1 time every day.
Comparative example 1
The cannabis extract was removed and the same as in example 2.
Comparative example 2
The procedure was as in example 2 except that cactus was removed.
Comparative example 3
The green tea extract was removed, and the procedure was the same as in example 2.
Comparative example 4
The cinnamon extract was removed and the same as in example 2.
Animal experiments
1 Material
1.1 animals
Kunming mouse, common level, half male and half female, weight 18-22 g; SD rats, male, weighing 180-.
1.2 drugs and reagents
Molding reagent: depilatory cream, carrageenan, histamine phosphate, and xylene.
The therapeutic drug is: the traditional Chinese medicine composition prepared in the embodiment of the invention and the comparative example.
2 method of experiment
2.1 Effect of Paraxylene-induced auricle swelling in mice
80 Kunming mice of 18-22g are randomly divided into 8 groups, each group comprises 10 mice, each male and female half are respectively a control group, an experimental group (3 groups) and a comparative experimental group (4 groups), the control group is coated with Daktarin ointment sold on the market, the experimental group is coated with the traditional Chinese medicine composition on the right ear of the mice respectively, 2 times a day are carried out continuously for 3 days, each group is washed off by distilled water 1 hour after the application on the 4 th day, and the mice are wiped clean by dry cotton balls. Then, 0.05 ml/mouse of xylene was applied to the right ear of each group of mice, the left ear was used as a control, the animals were sacrificed after 30 minutes, the equivalent parts of the left and right ears of the mice were cut out in an equal area by an 8mm punch, the mice were weighed by an electronic balance, the difference in weight between the left and right ears was used as the swelling degree, the swelling degree of each group was calculated, and the swelling inhibition rate was determined, and the results are shown in table 1.
TABLE 1 Effect of topical ointments on the degree of ear swelling in mice
| Group of | Only by | Weight difference of left and right ear (mg) |
| Control group | 10 | 5.786±1.6532 |
| Example 1 | 10 | 3.012±1.2134 |
| Example 2 | 10 | 3.012±1.2134 |
| Example 3 | 10 | 3.012±1.2134 |
| Comparative example 1 | 10 | 4.122±1.2556 |
| Comparative example 2 | 10 | 3.652±1.3214 |
| Comparative example 3 | 10 | 3.643±1.3256 |
| Comparative example 4 | 10 | 4.058±1.4123 |
The result shows that the traditional Chinese medicine composition can obviously reduce the swelling degree of mouse ears caused by dimethylbenzene and has obvious inhibition effect on swelling inflammation of mouse ears.
2.2 bacteriostatic action
The experimental method comprises the following steps: the test bacteria are prepared into bacterial suspension by normal saline, and diluted into bacterial suspension with the turbidity of more than 2.0McF, then diluted 100 times by normal saline, diluted 10 times by RPMII640, diluted twice by a test group (the traditional Chinese medicine composition prepared by the embodiment 1-3 of the invention), a comparative experiment group (the traditional Chinese medicine composition prepared by the comparative example 1-4 of the invention) and a control group (a commercial Daktarin ointment), cultured in a 96-hole culture plate for 72-96h, slightly shaken and subjected to photoelectric colorimetry at 490 nm.
Test bacteria: pathogenic Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Aspergillus niger, and Cryptococcus ruber.
The results of the inhibition are shown in Table 2.
TABLE 2 bacteriostatic effect
The results show that the traditional Chinese medicine composition has strong antibacterial effect on pathogenic escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, candida albicans, aspergillus niger and cryptococcus erythropolis.
Clinical trial
96 cases of paronychia patients are selected, and the patients are 16-60 years old; randomly dividing into 8 groups, namely a control group, an experimental group (3 groups) and a comparative experimental group (4 groups), wherein each group contains 12 people, and the male-female ratio is 1: 1; the data in 8 groups were not statistically significant.
The experimental group and the comparative experimental group are treated according to the using method of the traditional Chinese medicine composition, 2 times a day, and the treatment course is 7 days; the control group was coated with Daktarin ointment sold on the market 2 times a day for a treatment period of 7 days.
The standard of therapeutic effect refers to "Standard of therapeutic Effect for diagnosis of TCM diseases
Curing, namely eliminating the symptoms of the whole body, eliminating the gall and healing the sore;
improvement, the symptoms of the whole body subside, and the swelling and pain and the sore are not healed completely;
non-healing, an aggravation of local and systemic symptoms, a formation of decayed bone or a severe dysfunction of the hands. The total effective rate is the improvement of the cure.
The therapeutic effect is shown in table 3.
TABLE 3 curative effects
| Group of | Cure of disease | Improvement of life | Not cured | Overall effect |
| Control group | 3 | 6 | 3 | 9 |
| Example 1 | 8 | 4 | 0 | 12 |
| Example 2 | 10 | 2 | 0 | 12 |
| Example 3 | 9 | 3 | 0 | 12 |
| Comparative example 1 | 4 | 6 | 2 | 10 |
| Comparative example 2 | 4 | 7 | 1 | 11 |
| Comparative example 3 | 5 | 7 | 0 | 12 |
| Comparative example 4 | 5 | 6 | 1 | 11 |
The foregoing is considered as illustrative of the preferred embodiments of the invention, but is made merely for the purpose of providing an understanding of the principles of the embodiments; meanwhile, for a person skilled in the art, according to the present embodiment, there may be a change in the specific implementation and application scope, and in summary, the present disclosure should not be construed as a limitation to the present invention.
Claims (6)
1. A traditional Chinese medicine composition for treating paronychia is characterized in that: the feed comprises the following raw materials in parts by weight: 0.1-1 part of hemp extract, 3-10 parts of cactus, 5-15 parts of green tea extract, 8-20 parts of coptis extract and 0.5-1 part of cinnamon extract.
2. The traditional Chinese medicine composition for treating paronychia according to claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight: 0.5 part of hemp extract, 5 parts of cactus, 8 parts of green tea extract, 9 parts of coptis extract and 0.5 part of cinnamon extract.
3. The traditional Chinese medicine composition for treating paronychia according to claim 1 or 2, which is characterized in that: the content of cannabidiol in the cannabis leaf extract is more than 50%, and the content of tetrahydrocannabinol in the cannabis leaf extract is less than 0.3%.
4. The traditional Chinese medicine composition for treating paronychia according to claim 1 or 2, which is characterized in that: the green tea extract contains tea polyphenol more than or equal to 80% and berberine hydrochloride more than or equal to 10%.
5. The traditional Chinese medicine composition for treating paronychia according to claim 1 or 2, which is characterized in that: the cinnamon polyphenol content in the cinnamon extract is more than or equal to 30%.
6. A method of using the traditional Chinese medicine composition for treating paronychia according to claim 1, which is characterized in that: the method comprises the following steps:
(1) weighing hemp extract, green tea extract, coptis extract and cinnamon extract according to the weight parts, and uniformly mixing;
(2) removing thorns from fresh cactus, pounding into paste, squeezing, adding into the ointment obtained in step (1), and stirring and mixing uniformly to obtain traditional Chinese medicine ointment;
(3) and (3) the affected part is disinfected conventionally, then the traditional Chinese medicine ointment in the step (2) is applied, and the affected part is covered or bandaged by gauze and is replaced 1 time every day.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111643530A (en) * | 2020-05-13 | 2020-09-11 | 郜玉斌 | Paronychia treatment ointment and preparation method thereof |
| CN112972330A (en) * | 2021-03-01 | 2021-06-18 | 科丝美诗(中国)化妆品有限公司 | Composition for relieving itching and strengthening skin barrier and preparation and application thereof |
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2020
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643530A (en) * | 2020-05-13 | 2020-09-11 | 郜玉斌 | Paronychia treatment ointment and preparation method thereof |
| CN112972330A (en) * | 2021-03-01 | 2021-06-18 | 科丝美诗(中国)化妆品有限公司 | Composition for relieving itching and strengthening skin barrier and preparation and application thereof |
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