CN115337359B - External traditional Chinese medicine composition for treating mite dermatitis and preparation method thereof - Google Patents

Abstract

The invention discloses an external traditional Chinese medicine composition for treating mite dermatitis and a preparation method thereof, wherein the composition comprises the following raw materials in parts by weight: 10 to 20 portions of cocklebur fruit, 20 to 40 portions of broom cypress fruit, 15 to 30 portions of chinaberry bark, 10 to 20 portions of rhizoma bolbostemmae, 10 to 20 portions of coptis root, 10 to 20 portions of glabrous greenbrier rhizome, 6 to 12 portions of dried alum and 3 to 6 portions of menthol. 1) Taking the granules of cocklebur fruit, belvedere fruit, chinaberry bark, bolbostemma paniculatum, coptis and glabrous greenbrier rhizome according to the parts by weight; 2) Taking dried alum according to the weight parts and grinding; uniformly mixing the ground dried alum with the raw materials selected in the step 1); 3) Adding 20-30 ml of 0.9% physiological saline into the uniformly mixed material in the step 2), stirring until the mixture is thick paste, standing for more than 2 hours until the material is fully dissolved; 4) Adding 40-80 parts by weight of medical vaseline into the material obtained in the step 3) for mixing and melting; taking menthol according to parts by weight; then 20 to 30ml of medical ethanol with the concentration of 75 percent is taken; adding into the mixed materials, stirring, and making into ointment.

Description

External traditional Chinese medicine composition for treating mite dermatitis and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a dermatology externally-used traditional Chinese medicine; more particularly relates to an external traditional Chinese medicine composition for treating mite dermatitis and a preparation method thereof.

Background

Mite dermatitis is dermatitis caused by mites biting or contacting secretions of the mites, belongs to one of common diseases of dermatology, and is frequently generated by farmers contacting crops in summer and autumn. The onset of mite dermatitis is mainly rural children and teenagers in 3-9 months per year, and the onset is closely related to climate environmental factors of damp-heat and yin toxicity. Farmers who contact wheat, corn and weeds are particularly high-risk crowds, infants are susceptible to the disease generally, and the infectivity among family members is strong. After the skin is bitten by mites, the skin damage is manifested as a bright red to bright red spot rash, which is prone to pruritus and burning sensation, aggravates at night, and easily occurs on the neck, face and limbs, thus seriously affecting the sleep and physical and mental health of patients. Most western medicine treatments employ antihistamine, anti-infective treatments, and most patients, especially infants, are reluctant to receive this treatment regimen by their families.

Disclosure of Invention

The invention aims to provide a Chinese medicinal preparation which is simple and convenient to use, obvious in effect, safe and low in price and a preparation method thereof, and can be used for treating mite dermatitis and skin diseases such as allergic dermatitis, dermatitis herpetiformis, eczema, skin pruritus and the like caused by mite infection.

Therefore, the invention adopts the following technical scheme:

a topical Chinese medicinal composition for the treatment of mite dermatitis is prepared from fructus Xanthii, kochiae fructus, cortex Meliae, rhizoma Bolbostematis, coptidis rhizoma, rhizoma Smilacis Glabrae, dried Alumen and Mentholum as raw materials.

Further, the raw material medicinal materials are proportioned according to the following parts by weight:

10 to 20 portions of cocklebur fruit, 20 to 40 portions of broom cypress fruit, 15 to 30 portions of chinaberry bark, 10 to 20 portions of rhizoma bolbostemmae, 10 to 20 portions of coptis root, 10 to 20 portions of glabrous greenbrier rhizome, 6 to 12 portions of dried alum and 3 to 6 portions of menthol.

A preparation method of an external traditional Chinese medicine for treating mite dermatitis takes the traditional Chinese medicine composition as a raw material, and the preparation method comprises the following steps:

1) Taking the granules of cocklebur fruit, belvedere fruit, chinaberry bark, bolbostemma paniculatum, coptis and glabrous greenbrier rhizome according to the parts by weight;

2) Taking dried alum according to the weight parts and grinding; uniformly mixing the ground dried alum with the raw materials selected in the step 1);

3) Adding 20-30 ml of 0.9% physiological saline into the uniformly mixed material in the step 2), stirring until the mixture is thick paste, standing for more than 2 hours until the material is fully dissolved;

4) Adding 40-80 parts by weight of medical vaseline into the material obtained in the step 3) for mixing and melting;

taking menthol according to parts by weight; then 20 to 30ml of medical ethanol with the concentration of 75 percent is taken; adding into the mixed materials, and stirring to obtain ointment.

The efficacy and pharmacological action of the raw material medicine of the invention are as follows:

fructus Xanthii is fruit of Xanthium strumarium of Compositae. Nature, flavor and meridian tropism: bitter, pungent and slightly cold. It enters lung meridian due to slight toxicity. The efficacy is as follows: dispelling pathogenic wind, clearing heat, removing toxic substance, and killing parasite. It is mainly used for treating pyocutaneous disease due to heat toxin, skin pruritus, etc. The fructus Xanthii contains cocklebur fruit glycoside, linoleic acid, chalcone derivatives, etc. The water decoction has effect in inhibiting Staphylococcus aureus in vitro. The acetone or ethanol extract has inhibitory effect on Trichophyton rubrum in vitro.

The property, flavor and channel tropism of the broom cypress fruit: bitter and cold. It enters bladder meridian. The efficacy is as follows: clearing away heat, inducing diuresis and relieving itching. The Chinese medicine dictionary: promoting urination and clearing away damp-heat. Treating leukorrhagia, sore, toxin, scabies and tinea. Original materia Medica: "removing heat in skin, and relieving itching except skin". Pharmacological research proves that the water extract of the belvedere fruit has the function of inhibiting various dermatophytes

The cortex meliae has the property of flavor and meridian tropism: bitter and cold. It enters spleen, stomach and liver meridians. The efficacy is as follows: killing parasites and curing tinea. Chinese medicine dictionary: clearing heat, drying dampness, killing parasites, treating rubella and scabies. Rihuazi Bencao: it is indicated for wind-damp heat-toxin, rubella, sore, scabies and scabies.

The property, flavor and meridian tropism of paniculate Bolbostemma rhizome: bitter and slightly cold. It enters lung and liver meridians. The efficacy is as follows: dissipate stagnation and cure abscess. The herbal supplement: for sores and abscess and snake venom. . Pharmacological research proves that the tubeimoside has obvious anti-inflammatory and antiviral effects.

The nature, flavor and meridian tropism of coptis: bitter and cold. It enters heart, liver, stomach and large intestine meridians. The efficacy is as follows: clear heat and dry dampness, purge fire and remove toxicity. The Chinese medicine dictionary: purging fire, drying dampness, removing toxicity and killing parasites. It is indicated for abscess, deep-rooted carbuncle, sore and eczema. The materia Medica is in the future: bitter and cold. For abscess, deep-rooted carbuncle, sore and scabies, malnutrition and ascarid removal. Pharmacological research proves that berberine in rhizoma Coptidis has strong antibacterial effect on Staphylococcus aureus, and decoction and water extract thereof have inhibitory effect on various dermatophytes, and can accelerate wound healing.

Rhizoma smilacis glabrae property flavor meridian tropism: sweet and bland, neutral. Meridian tropism: the liver, stomach and spleen meridians. The efficacy is as follows: to remove dampness and remove toxicity. Compendium of materia Medica: for spasm and pain of bones, malignant sore, carbuncle and swelling, and removing mercury toxicity. Pharmacological research proves that the glabrous greenbrier rhizome water extract has obvious bacteriostatic action on staphylococcus aureus, staphylococcus albus and the like, and has better bacteriostatic activity in vitro.

Dried alum with original flavor and meridian tropism: sour and cold. It enters lung, liver, spleen, stomach and large intestine meridians. The efficacy is as follows: detoxify and kill parasites, dry dampness and relieve itching, stop bleeding and stop diarrhea, clear heat and resolve phlegm. Compendium of materia Medica: sour and astringent taste, cold nature, and slight toxicity. It enters spleen, lung, stomach and large intestine channels, and is used externally to eliminate dampness and toxic material, astringe, stop bleeding, kill parasites, relieve pain and relieve pain. "Shen nong Ben Cao Jing: "governing erosion of the vulva and malignant sores". Pharmacological research proves that the dried alum has an inhibiting effect on pathogenic bacteria such as staphylococcus aureus, proteus and the like, and can promote healing of ulcer surfaces.

The menthol has the efficacies of dispelling wind, clearing heat and detoxifying, and is mainly used for treating sore throat, tooth swelling and pain, headache, mouth and tongue sores, rubella, measles and the like in clinic. Pharmacological research proves that the menthol can diminish inflammation, relieve pain, relieve itching, promote blood circulation, relieve edema and the like when externally used.

The medical vaseline is a cerate extracted from residual oil left after the crude oil is distilled under normal pressure and reduced pressure, is used as an ointment matrix and can moisten skin.

The granule is dissolved in 0.9% normal saline.

Dissolving Mentholum with 75% medical ethanol, and sterilizing.

The compatibility mechanism of the invention is as follows:

in the external formula, fructus xanthil, fructus kochiae and cortex meliae are used as monarch drugs for removing damp-heat from the skin and killing parasites to relieve itching; the traditional Chinese medicine composition is matched with paniculate Bolbostemma rhizome for dispersing accumulation of pathogen, coptis chinensis with bitter cold and dampness eliminating effects and glabrous greenbrier rhizome for promoting blood circulation and cooling blood as ministers; the dried alum for disinsection and detoxification and the menthol for resuscitation and filth avoidance are dissolved into particles by 0.9 percent of normal saline, medical vaseline for moistening skin is used as a matrix, and 75 percent of medical ethanol is used for disinfection and antisepsis. The traditional Chinese medicine ointment prepared by the monarch, minister, assistant and guide components together has the functions of clearing away skin damp toxin, killing parasites and relieving itching, and is used for treating mite dermatitis and skin diseases such as allergic dermatitis, herpetiform dermatitis, eczema, skin pruritus and the like caused by mite dermatitis infection. Has the advantages of obvious curative effect, safe use, simple and convenient preparation, low cost and the like.

Can be used for the following main treatment: clearing away damp-toxin, killing parasites and relieving itching. Can be used for treating mite dermatitis, allergic dermatitis, dermatitis herpetiformis, and skin pruritus caused by mite infection.

The usage and dosage are as follows: for external use, the ointment is dipped and applied to the affected part by a sterilized cotton swab 2-3 times per day according to the size of the rash

Medication contraindications: it is forbidden for patients allergic to this herb.

Note that:

1. the product is for external use, but not for oral administration.

2. Pregnant women and people with allergic constitution should use with cautions.

3. The product is forbidden to use when its properties are changed.

4. If the site of application has burning sensation, itching, red swelling, etc., the application should be stopped, and the patient should be cleaned with clear water and consulted with the physician if necessary.

5. Children must be under adult supervision.

The storage method comprises the following steps: placing in shade.

The invention has the beneficial effects that:

the raw materials adopted by the invention are easy to obtain, and the price of the raw materials is low, so that the preparation cost of the medicine can be reduced; the medicine is simple in preparation method, easy to prepare and convenient to popularize in hospitals or consulting rooms lacking in basic equipment; the invention can treat mite dermatitis and skin diseases such as allergic dermatitis, dermatitis herpetiformis, eczema, skin pruritus and the like caused by mite infection; has the advantages of obvious curative effect, safe use, simple and convenient preparation, low cost and the like.

Detailed Description

The invention will be further illustrated with reference to specific embodiments:

example 1:

the raw material ratio is as follows: 10 parts of cocklebur fruit, 20 parts of fructus kochiae, 15 parts of cortex meliae, 10 parts of rhizoma bolbostemmae, 10 parts of coptis chinensis, 10 parts of rhizoma smilacis glabrae, 6 parts of dried alum and 3 parts of menthol;

auxiliary materials: 20ml of 0.9 percent physiological saline, 20ml of 75 percent medical ethanol and 40 parts of medical vaseline.

The preparation method comprises the following steps:

1) Taking granules of cocklebur fruit, belvedere fruit, chinaberry bark, rhizoma bolbostemmae, coptis chinensis and rhizoma smilacis glabrae;

2) Taking dried alum and grinding; uniformly mixing the porphyrized dried alum and the raw materials selected in the step 1);

3) Adding physiological saline with the concentration of 0.9% into the uniformly mixed materials in the step 2), stirring to be thick paste, standing for more than 2 hours, and fully dissolving the materials;

4) Adding medical vaseline into the material obtained in the step 3) according to the parts by weight for mixing and melting;

taking menthol and 75% medical ethanol according to parts by weight; adding into the mixed materials, and stirring to obtain ointment.

Example 2:

the raw material ratio is as follows: 10 parts of cocklebur fruit, 40 parts of fructus kochiae, 15 parts of cortex meliae, 10 parts of rhizoma bolbostemmae, 20 parts of coptis chinensis, 15 parts of rhizoma smilacis glabrae, 6 parts of dried alum and 6 parts of menthol;

auxiliary materials: 20ml of 0.9% physiological saline, 20ml of 75% medical ethanol and 40 parts of medical vaseline.

The preparation method comprises the following steps:

1) Taking granules of cocklebur fruit, belvedere fruit, chinaberry bark, rhizoma bolbostemmae, coptis chinensis and rhizoma smilacis glabrae;

2) Taking dried alum and grinding; uniformly mixing the porphyrized dried alum and the raw materials selected in the step 1);

3) Adding physiological saline with the concentration of 0.9% into the uniformly mixed materials in the step 2), stirring to be thick paste, standing for more than 2 hours, and fully dissolving the materials;

4) Adding medical vaseline into the material obtained in the step 3) according to the parts by weight for mixing and melting;

taking menthol and 75% medical ethanol according to parts by weight; adding into the mixed materials, and stirring to obtain ointment.

Example 3:

the raw material ratio is as follows: 15 parts of cocklebur fruit, 20 parts of fructus kochiae, 30 parts of cortex meliae, 15 parts of rhizoma bolbostemmae, 10 parts of coptis chinensis, 20 parts of rhizoma smilacis glabrae, 8 parts of dried alum and 3 parts of menthol;

auxiliary materials: 25ml of 0.9 percent physiological saline, 25ml of 75 percent medical ethanol and 60 parts of medical vaseline.

The preparation method comprises the following steps:

1) Taking granules of cocklebur fruit, belvedere fruit, chinaberry bark, rhizoma bolbostemmae, coptis chinensis and rhizoma smilacis glabrae;

2) Taking dried alum and grinding; uniformly mixing the porphyrized dried alum and the raw materials selected in the step 1);

3) Adding physiological saline with the concentration of 0.9% into the uniformly mixed materials in the step 2), stirring to be thick paste, standing for more than 2 hours, and fully dissolving the materials;

4) Adding medical vaseline into the material obtained in the step 3) according to the parts by weight for mixing and melting;

taking menthol and 75% medical ethanol in parts by weight; adding into the mixed materials, stirring, and making into ointment.

Example 4:

the raw material ratio is as follows: 20 parts of cocklebur fruit, 30 parts of broom cypress fruit, 20 parts of chinaberry bark, 20 parts of bolbostemma paniculatum, 15 parts of coptis chinensis, 10 parts of glabrous greenbrier rhizome, 12 parts of dried alum and 4 parts of menthol;

auxiliary materials: 30ml of 0.9 percent physiological saline, 30ml of 75 percent medical ethanol and 80 parts of medical vaseline.

The preparation method comprises the following steps:

1) Taking granules of cocklebur fruit, belvedere fruit, chinaberry bark, rhizoma bolbostemmae, coptis chinensis and rhizoma smilacis glabrae;

2) Taking dried alum and grinding; uniformly mixing the ground dried alum with the raw materials selected in the step 1);

3) Adding 0.9% physiological saline into the uniformly mixed material in the step 2), stirring to be thick paste, standing for more than 2 hours until the material is fully dissolved;

4) Adding medical vaseline into the material obtained in the step 3) according to the parts by weight for mixing and melting;

taking menthol and 75% medical ethanol according to parts by weight; adding into the mixed materials, stirring, and making into ointment.

The effect of the present invention will be further described below with reference to clinical data and typical cases.

The functional indications are as follows: clearing away damp-toxin, killing parasites and relieving itching. Can be used for treating mite dermatitis and allergic dermatitis, dermatitis herpetiformis, and skin pruritus caused by mite infection.

The usage and dosage are as follows: for external use, the ointment is dipped and applied to the affected part by a sterilized cotton swab 2-3 times per day according to the size of the rash

Medication contraindications: it is forbidden for patients allergic to this herb.

Note that 1, the product is for external use, and should not be taken orally.

2. It should be used with cautions for pregnant women and people with allergic constitution.

3. The product is forbidden to use when its properties are changed.

4. If the site of application has burning sensation, itching, red swelling, etc., the application should be stopped, and the patient should be cleaned with clear water and consulted with the physician if necessary.

5. Children must use under adult supervision.

The storage method comprises the following steps: placing in shade.

1. Clinical data

182 cases of mite dermatitis are randomly divided into 100 cases of treatment groups and 82 cases of control groups, and the treatment groups are externally coated with the mite removing cream; mupirocin ointment was given as an external coating to the control group. After observation for 1 week, the control group had 12 cases of recovery, 32 cases of efficacy, 8 improvement cases and 30 cases of no efficacy. The total effective rate is 63.4%; 92 cases are cured in the treatment group, 5 cases are effective, 1 case is improved, 2 cases are ineffective, and the total effective rate is 98.0%.

Adverse reactions: obvious adverse reactions such as skin erythema, dryness, burning sensation, burning pain, blister, pigmentation and the like are not seen in the treatment process.

Note that:

(1) The invention is a topical ointment, which is only used for external application and can not be taken orally.

(2) The skin can be peeled off automatically after scabbing, and the scab cannot be peeled off from the skin lesion too early.

(3) The skin can not be smeared with cream or other skin care products in the decrustation position within 7 days after the skin lesion is removed, so as to avoid color spots.

2. Typical cases

Example 1 the patient was diagnosed at 21/6/2022 and on a 21/6 day old day by a Li-chi male, a 15 year old, 3 days before weekend, and after the father was working in the field in the corn field, the irregular reddish pimples with itching symptoms appeared on the neck, trunk and limbs at 10 nights until 7 am, and the itching symptom was relieved, and the treatment effect of externally applying the mupirocin ointment was not obvious. It is diagnosed that the neck, trunk and limbs are irregular and generalized with central protuberant reddish pimples, some of the pimples scratch the skin ulceration, the itching is severe at night, the tongue is pale and reddish, the tongue coating is yellow and greasy, and the pulse is soft and rapid. And (3) Western diagnosis: mite dermatitis. Traditional Chinese medicine diagnosis: pruritus due to millet and grass, syndrome type: syndrome of dampness-heat and insect toxicity accumulated in skin. For treatment, it can clear damp-toxin, kill parasites and relieve itching. The ointment for removing mite is applied externally, and the ointment is dipped in a sterilized cotton swab and applied to the affected part 3 times a day. After continuous treatment for 5 days, the pimple fades, the pruritus symptom disappears, and no relapse is seen in the follow-up telephone.

Example 2 the female, teacher, was diagnosed at 52 years old, and after 3 days 7 months in 2022, the female had a wet environment before 1 month, and had a red papule scattered around the body, a small amount of exudation on the top of the papule, increased itching at night, pale tongue, white and greasy tongue coating, and superficial and rapid pulse. And (3) Western diagnosis: mite dermatitis. Traditional Chinese medicine diagnosis: pruritus of millet and grass, syndrome type: damp-heat and noxious-insect can accumulate in the skin. For treatment, it can clear damp-toxin, kill parasites and relieve itching. The mite-removing ointment is externally coated, and the disinfected cotton swab is dipped in the mite-removing ointment and then is coated on the affected part. It is administered 3 times daily. The rash can be removed and the itching can be stopped after 3 days of continuous treatment, and no relapse can be seen after 1 month of telephone follow-up.

Claims (1)

1. A Chinese medicinal composition for external use for treating mite dermatitis is characterized in that the Chinese medicinal composition is prepared by taking cocklebur fruit, broom cypress fruit, chinaberry bark, rhizoma bolbostemmae, coptis chinensis, glabrous greenbrier rhizome, dried alum and menthol as raw medicinal materials;

the raw medicinal materials are proportioned according to the following parts by weight: 10 to 20 portions of cocklebur fruit, 20 to 40 portions of broom cypress fruit, 15 to 30 portions of chinaberry bark, 10 to 20 portions of rhizoma bolbostemmae, 10 to 20 portions of coptis root, 10 to 20 portions of glabrous greenbrier rhizome, 6 to 12 portions of dried alum and 3 to 6 portions of menthol;

the preparation method of the traditional Chinese medicine composition comprises the following steps:

1) Taking the granules of cocklebur fruit, belvedere fruit, chinaberry bark, bolbostemma paniculatum, coptis and glabrous greenbrier rhizome according to the parts by weight;

2) Taking dried alum according to the weight part and grinding the dried alum; uniformly mixing the porphyrized dried alum and the raw materials selected in the step 1);

3) Adding 20-30 ml of 0.9% physiological saline into the uniformly mixed material in the step 2), stirring until the mixture is thick paste, standing for more than 2 hours until the material is fully dissolved;

4) Adding 40-80 parts by weight of medical vaseline into the material obtained in the step 3) for mixing and melting;

taking menthol according to parts by weight; then 20 to 30ml of medical ethanol with the concentration of 75 percent is taken; adding into the mixed materials, stirring, and making into ointment.