CN111773267A

CN111773267A - A Chinese medicinal composition with antiinflammatory and analgesic effects, and its preparation method

Info

Publication number: CN111773267A
Application number: CN202010733159.XA
Authority: CN
Inventors: 于际显
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-27
Filing date: 2020-07-27
Publication date: 2020-10-16

Abstract

The invention provides a traditional Chinese medicine composition for diminishing inflammation and relieving pain, which has the advantages that through the combined action of all medicinal materials, on one hand, the traditional Chinese medicine composition has the effects of inhibiting bacteria and improving the phagocytic capacity of a human body, fundamentally eliminates inflammation, on the other hand, the traditional Chinese medicine composition has good treatment effect on symptoms caused by inflammation, treats both symptoms and root causes, and achieves the purpose of quick and good treatment. The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention takes the menthol as a monarch drug, and the monarch drug selectively stimulates the skin of a human body to cause vasoconstriction of skin mucous membrane and deep tissues and inhibit the growth of bacteria, thereby achieving good effects of diminishing inflammation and relieving pain; camphor and borneol are taken as ministerial drugs, the ministerial drugs can inhibit the growth of bacteria and strengthen the effect of the monarch drugs on one hand, and on the other hand, the phagocytic function of phagocytes is enhanced through clearing heat, the nonspecific immunity function is improved, and the inflammation is eliminated; the invention takes mirabilite as adjuvant drug, takes borax as conductant drug, and the adjuvant drug and the conductant drug assist monarch drug and ministerial drug to achieve the effects of detumescence, relieving pain, activating blood circulation to dissipate blood stasis and diminishing inflammation.

Description

A Chinese medicinal composition with antiinflammatory and analgesic effects, and its preparation method

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an anti-inflammatory and analgesic traditional Chinese medicine composition and a preparation method thereof.

Background

Inflammation refers to a reaction of living tissues having a vascular system, mainly in defense against inflammatory factors, and a central link is a vascular reaction. Inflammation is a defense response of the body to stimuli and is manifested as redness, swelling, heat, pain. Vascular responses are a central link in the inflammatory process. Normally, inflammation is beneficial and an automatic defense response of the human body, but sometimes, inflammation is also harmful, such as attack on the body's own tissues, inflammation occurring in transparent tissues, and the like. During inflammation, the damage factors directly or indirectly cause tissue and cell destruction on the one hand, and on the other hand, through inflammatory hyperaemia and exudative reactions, to dilute, kill and enclose the damage factors. While the damaged tissue is repaired and healed by regeneration of parenchymal and mesenchymal cells. Inflammation can therefore be said to be a uniform process of injury and anti-injury. Any factor that can cause tissue damage can be the cause of inflammation, i.e., an inflammatory factor. Inflammatory factors can be classified into biological factors, physical factors, chemical factors, foreign substances, necrotic tissues, allergic reactions, and the like. In some cases, inflammation is potentially harmful. Inflammatory responses are the basis for the pathogenesis of several diseases, for example severe hypersensitivity reactions where inflammation is too severe can threaten the life of the patient. In addition, inflammation occurring in a specific part or organ may have serious consequences, such as brain or brain inflammation that may press the vital center, vocal cord inflammation that blocks the throat to cause asphyxia, and severe myocarditis that may affect cardiac function, in which case anti-inflammatory drugs should be used to suppress the inflammatory response.

At present, most of anti-inflammatory medicines with outstanding efficacy in the prior art are antibiotics, such as amoxicillin, cefamycin, aspirin and the like, and unpredictable side effects u, such as anaphylactic reaction, even shock and the like, easily occur in the using process of the medicines; the abuse of antibiotics can cause the drug resistance of the microorganisms to be treated, and the emergence of drug-resistant bacteria. In the field of traditional Chinese medicine, among numerous Chinese patent medicines, the traditional Chinese medicine with the anti-inflammatory effect generally has a slow curative effect.

Disclosure of Invention

In order to solve the technical problems, the invention provides the traditional Chinese medicine composition with outstanding and quick effects of diminishing inflammation and relieving pain and the preparation method thereof.

The invention aims to provide a traditional Chinese medicine composition for diminishing inflammation and relieving pain.

The invention also aims to provide a preparation method of the traditional Chinese medicine composition for diminishing inflammation and relieving pain.

The invention also aims to provide application of the traditional Chinese medicine composition for diminishing inflammation and relieving pain.

The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention comprises the following raw materials in parts by weight:

8-12 parts of borneol,

12-20 parts of borax, namely, borax,

8-12 parts of mirabilite,

8-12 parts of camphor, namely camphor oil,

12-20 parts of mint cream.

Borneol, pungent and bitter, cool; heart and lung meridian entered; has the main functions of dredging orifices, dispelling stagnated fire, removing nebula, improving eyesight, reducing swelling and relieving pain. It is indicated for wind stroke, vomiting, coma due to febrile disease, epilepsy due to convulsion, phlegm-phlegm, qi block, deafness, sore throat, aphtha, otitis media, carbuncle, swelling, hemorrhoid, nebula, and enterobiasis. Borneol contains various terpenoids, and also contains sesquiterpene components such as Humulene (Humulene), beta-Elemene (beta-Elemene), Caryophyllene (caryophylelene), Oleanolic acid (Oleanolic acid), bulbar acid (alpithinocaicid), Asiatic acid (Asiatic acid), camphol ketone (Dipterocarpol, Hydroxydammaranone II), camphol ketone (Dryobalanone), Erythrodiol (Erythrodiol), etc.

The traditional Chinese medicine borax is a crystal prepared by refining and refining natural mineral borax sand. Sweet, salty and cool; entering lung and stomach meridians; it can clear heat and remove toxicity for external application, clear lung heat and resolve phlegm for internal application. Borax has inhibitory effect on various gram positive and gram negative bacteria, superficial dermatophytes and Candida albicans to different degrees. Has astringent and protective effects on skin and mucosa.

Natrii sulfas is salty, bitter and cold; entering stomach and large intestine meridians; the functions are mainly used for purging heat, relaxing bowels, moistening dryness, softening hard masses, clearing away fire and reducing swelling. Used for treating excessive heat constipation, abdominal pain due to stagnation, and intestinal abscess with swelling and pain; it is indicated for acute mastitis, hemorrhoid with swelling and pain.

Camphor, pungent and warm. The functions are mainly used for dredging orifices and removing dirt, warming middle-jiao and relieving pain, and promoting diuresis and killing insects. Can be used for treating vomiting and diarrhea due to cold-dampness, and stomach and abdominal pain; it is externally used for treating scabies, tinea and pain caused by dental caries. The camphor has mild irritation and antiseptic effect when applied to skin. It can be applied forcefully to treat reddening hair; light application is like peppermint, with a cooling sensation due to stimulation of the cold receptors. It also has mild local anesthetic action.

The menthol cream mainly comprises menthol, flavone avocado substances, organic acid and the like, and has the effects of clearing and brightening, dispelling wind, diminishing inflammation and locally anaesthetizing.

The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention takes the mint cream as a monarch drug, the monarch drug effectively treats inflammatory factors, and active ingredients in the mint cream can selectively stimulate human skin to cause vasoconstriction of skin mucous membrane and deep tissue, inhibit the growth of bacteria and achieve good effects of diminishing inflammation and relieving pain; according to the invention, camphor and borneol are taken as ministerial drugs, and the ministerial drugs act together, so that on one hand, the anti-inflammation and detumescence effects of the monarch drugs are enhanced by inhibiting the growth of bacteria, on the other hand, the ministerial drugs act together to play a role in clearing heat, the phagocytic function of phagocytes is obviously enhanced by means of clearing heat, and the nonspecific immunity function is improved to eliminate inflammation; the invention takes mirabilite as adjuvant drug, takes borax as conductant drug, and the adjuvant drug and the conductant drug assist monarch drug and ministerial drug to achieve the effects of detumescence, relieving pain, activating blood circulation to dissipate blood stasis and diminishing inflammation.

The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention has the advantages that through the combined action of all the medicinal materials, on one hand, the growth of harmful bacteria is inhibited, the phagocytic capacity of a human body is improved, the inflammation is fundamentally eliminated, on the other hand, the traditional Chinese medicine composition has good treatment effects on various symptoms of pain, fester and the like caused by the inflammation, the blood circulation is promoted, the blood stasis is removed, the swelling and the pain are relieved, and the treatment effect is achieved, so that the good treatment purpose.

The anti-inflammatory and analgesic traditional Chinese medicine composition preferably comprises the following raw materials in parts by weight:

10 parts of borneol,

15 parts of borax, namely, sodium borate,

10 parts of mirabilite, namely 10 parts of sodium sulfate,

10 parts of camphor, namely camphor, and the like,

15 parts of mint cream.

The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention is prepared from the raw materials according to the proportion, and the obtained traditional Chinese medicine composition has more remarkable effects of diminishing inflammation, relieving pain, reducing swelling and removing blood stasis. Has high treatment efficiency on various diseases caused by inflammation, particularly skin diseases.

Preferably, the preparation method of the menthol cream comprises the following steps: taking dried mint leaves, crushing, sieving, adding into water, distilling to obtain mint crude oil, adding the mint crude oil into an extraction kettle, extracting by adopting supercritical carbon dioxide to obtain mint oil, and cooling and crystallizing the mint oil to obtain the mint cream.

Preferably, the weight ratio of the mint leaves to the water is 1: 7-10.

Preferably, the temperature of the supercritical carbon dioxide extraction is 37-45 ℃, the pressure is 8.5-9.5 MPa, and the flow rate of the carbon dioxide is 2-4L/min.

Preferably, the temperature of the cooling crystallization is-20 to 0 ℃.

The menthol provided by the invention firstly extracts the peppermint crude oil in the peppermint leaves by a distillation method, then extracts the volatile oil of the active ingredients by a supercritical carbon dioxide extraction method, and finally, the extract of the active ingredients with high purity is obtained by cooling and crystallizing. The menthol crystal provided by the invention has high yield and high purity.

The invention provides a preparation method of the traditional Chinese medicine composition for diminishing inflammation and relieving pain, which comprises the following steps:

(1) weighing borneol, borax, mirabilite, camphor and menthol, uniformly mixing to obtain a mixture, placing the mixture in a sealed container, heating until the mixture is volatilized, condensing the volatile matter to the wall of the container, and collecting the volatile matter to obtain the anti-inflammatory and analgesic traditional Chinese medicine powder;

(2) and (2) adding the traditional Chinese medicine powder obtained in the step (1) into cold boiled water for soaking to obtain the traditional Chinese medicine composition for diminishing inflammation and relieving pain.

Preferably, in the step (2), the powder is added into cold boiled water to be soaked for 5-10 days.

Preferably, in the step (2), the weight ratio of the powder to the cold boiled water is 1: 300-350.

The preparation method of the traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention obtains high-purity effective components of the medicine in a heating volatilization-condensation mode, improves the treatment efficiency of the medicine, and then fully dissolves the effective components of the medicine in water in a soaking mode, so that the medicine is convenient and efficient in the using process.

The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention can be applied to preparation of medicines for treating mosquito bites.

The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention has the effect of stimulating and shrinking skin, generates cool feeling in the using process, has the effects of diminishing inflammation and relieving pain, and promoting blood circulation to remove blood stasis, can be used for treating skin diseases such as mosquito bites and eczema, can quickly relieve discomfort such as pruritus and pain caused by mosquito bites and eczema through the generated cool feeling, and can quickly treat the skin diseases through the inflammation diminishing effect.

The invention has the beneficial effects that:

1. the traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention has the advantages that through the combined action of all the medicinal materials, on one hand, the growth of harmful bacteria is inhibited, the phagocytic capacity of a human body is improved, the inflammation is fundamentally eliminated, on the other hand, the traditional Chinese medicine composition has good treatment effects on various symptoms of pain, fester and the like caused by the inflammation, and both symptoms and root causes are treated, so that the quick and good treatment aim is achieved.

2. The traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention takes the mint cream as a monarch drug, the monarch drug effectively treats inflammatory factors, and active ingredients in the mint cream can selectively stimulate human skin to cause vasoconstriction of skin mucous membrane and deep tissue, inhibit the growth of bacteria and achieve good effects of diminishing inflammation and relieving pain; according to the invention, camphor and borneol are taken as ministerial drugs, and the ministerial drugs act together, so that on one hand, the anti-inflammation and detumescence effects of the monarch drugs are enhanced by inhibiting the growth of bacteria, on the other hand, the ministerial drugs act together to play a role in clearing heat, the phagocytic function of phagocytes is obviously enhanced by means of clearing heat, and the nonspecific immunity function is improved to eliminate inflammation; the invention takes mirabilite as adjuvant drug, takes borax as conductant drug, and the adjuvant drug and the conductant drug assist monarch drug and ministerial drug to achieve the effects of detumescence, relieving pain, activating blood circulation to dissipate blood stasis and diminishing inflammation.

3. The preparation method of the traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention is simple to operate, can be produced in batch, and the obtained traditional Chinese medicine composition for diminishing inflammation and relieving pain has an outstanding effect and is convenient to use.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

A traditional Chinese medicine composition for diminishing inflammation and relieving pain comprises the following raw materials by weight:

8g of borneol,

12g of borax, namely 12g of borax,

8g of mirabilite, 8g,

8g of camphor, namely camphor, 8g of camphor,

12g of mint cream;

the preparation method of the mint cream comprises the following steps: taking dried mint leaves, crushing, sieving, adding the dried mint leaves into water with the weight 7 times that of the mint leaves, distilling to obtain mint crude oil, adding the mint crude oil into an extraction kettle, extracting by using supercritical carbon dioxide, wherein the temperature of the supercritical carbon dioxide extraction is 37 ℃, the pressure is 8.5MPa, and the flow of the carbon dioxide is 2L/min to obtain mint oil, and cooling and crystallizing the mint oil at the temperature of-20 ℃ to obtain the mint cream.

The preparation method of the traditional Chinese medicine composition for diminishing inflammation and relieving pain comprises the following steps:

(2) and (2) adding the traditional Chinese medicine powder obtained in the step (1) into cold boiled water with the weight being 300 times that of the traditional Chinese medicine powder, and soaking for 5 days to obtain the traditional Chinese medicine composition for diminishing inflammation and relieving pain.

Example 2

12g of borneol,

20g of borax,

12g of mirabilite, 12g,

12g of camphor, namely camphor, and 12g of camphor,

20g of mint cream;

the preparation method of the mint cream comprises the following steps: taking dried mint leaves, crushing, sieving, adding the dried mint leaves into 10 times of water by weight, distilling to obtain mint crude oil, adding the mint crude oil into an extraction kettle, extracting by using supercritical carbon dioxide, wherein the temperature of the supercritical carbon dioxide extraction is 45 ℃, the pressure is 9.5MPa, and the flow of the carbon dioxide is 4L/min to obtain mint oil, and cooling and crystallizing the mint oil at 0 ℃ to obtain the mint cream.

(2) and (2) adding the traditional Chinese medicine powder obtained in the step (1) into cold boiled water with the weight 350 times that of the traditional Chinese medicine powder, and soaking for 10 days to obtain the traditional Chinese medicine composition for diminishing inflammation and relieving pain.

Example 3

10g of borneol,

15g of borax,

9g of mirabilite, 9g,

the camphor content is 11g, and the camphor content is 11g,

18g of mint cream;

the preparation method of the mint cream comprises the following steps: taking dried mint leaves, crushing, sieving, adding the dried mint leaves into water with the weight of 8 times, distilling to obtain mint crude oil, adding the mint crude oil into an extraction kettle, extracting by adopting supercritical carbon dioxide, wherein the temperature of the supercritical carbon dioxide extraction is 40 ℃, the pressure is 9MPa, and the flow of the carbon dioxide is 2L/min to obtain mint oil, and cooling and crystallizing the mint oil at the temperature of-20 ℃ to obtain the mint cream.

(2) and (2) adding the traditional Chinese medicine powder obtained in the step (1) into cold boiled water with the weight being 315 times that of the traditional Chinese medicine powder, and soaking for 10 days to obtain the traditional Chinese medicine composition for diminishing inflammation and relieving pain.

Example 4

10g of borneol,

15g of borax,

10g of mirabilite, 10g,

10g of camphor, namely camphor, and the like,

15g of mint cream;

Comparative example 1

6g of borneol,

25g of borax, 25g of water,

6g of mirabilite, 6g,

6g of camphor, namely camphor,

10g of mint cream;

Comparative example 2

10g of borneol,

15g of borax,

10g of mirabilite, 10g,

10g of camphor;

(1) weighing borneol, borax, mirabilite and camphor, uniformly mixing to obtain a mixture, placing the mixture in a sealed container, heating until volatilization occurs, condensing the volatile matter to the wall of the container, and collecting the volatile matter to obtain the anti-inflammatory and analgesic traditional Chinese medicine powder;

Test examples

Collecting Staphylococcus aureus and Candida albicans, activating to obtain strain with a strain content of 1 × 10⁸And (3) adding 1ml of bacterial liquid of cfu/ml into the liquid culture medium to obtain a bacterial-containing plate.

Taking 6 groups of sterile filter papers with the diameter of 6mm, then respectively placing 3 groups of sterile filter papers on 3 plates containing staphylococcus aureus, respectively placing 3 groups of sterile filter papers on 3 plates containing candida albicans, then respectively taking the traditional Chinese medicine compositions obtained in the embodiment 4, the comparative example 1 and the comparative example 2, and respectively dripping 10 mu L of the traditional Chinese medicine compositions obtained in the embodiment 4, the comparative example 1 and the comparative example 2 on the 3 groups of plates containing staphylococcus aureus; 10. mu.L of each of the Chinese medicinal compositions obtained in example 4, comparative example 1 and comparative example 2 was dropped on 3 groups of plates containing Candida albicans, and then the 6 groups of plates were placed in an incubator at 37 ℃ and cultured for 48 hours, and the diameter of the zone of inhibition was measured. The results are shown in Table 1.

TABLE 1 results of bacteriostasis

As can be seen from the results in table 1, the anti-inflammatory and analgesic Chinese medicinal composition (liquid) obtained in example 4 of the present invention is excellent in inhibiting staphylococcus aureus and candida albicans, and has a diameter of about 20mm for inhibiting the bacteriostatic ring of staphylococcus aureus, and a diameter of about 18mm for inhibiting the bacteriostatic ring of candida albicans; however, when the traditional Chinese medicine raw materials provided by the invention are prepared according to the weight ratio exceeding that provided by the invention, the bacteriostatic effect of the obtained traditional Chinese medicine composition (liquid) is far inferior to that of the traditional Chinese medicine composition provided by the invention, and after the menthol in the traditional Chinese medicine composition is removed, the bacteriostatic effect of the traditional Chinese medicine composition obtained in the comparative example 2 is far inferior to that of the traditional Chinese medicine composition provided by the embodiment 4 of the invention under the same concentration. The invention fully shows that the traditional Chinese medicine composition for diminishing inflammation and relieving pain provided by the invention achieves good antibacterial and anti-inflammatory effects through the combined action of the raw materials and the weight ratio of the raw materials.

Partial typical case

1. Lu Yi, Juye county, Tai Ping Zhen, in villages, age 72 years old, with pain in the feet and knees, and accumulated fluid in the knees, accompanied with hyperosteogeny, and not cured for a long time, from the initial pain to 20 years before using the medicine of the present invention, the anti-inflammatory and analgesic Chinese medicinal composition obtained in example 4 of the present invention is used for treatment, the spraying is performed twice a day, and the massage is performed on the corresponding position for two months, the swelling and pain is eliminated, the accumulated fluid disappears, and the legs return to normal state.

2. Wu-Chi, Juye county, Touguan town, Wutangvillage, suffering from angiitis, treated for one month by county hospital, the doctor recommends cutting off two toes for treatment; the anti-inflammatory and analgesic traditional Chinese medicine composition obtained in the embodiment 4 of the invention is used for treatment, the affected part is cleaned once a day by using the medicine, and the disease is cured after being continuously used for half a month until now, and no recurrence exists.

3. Zhaoji, 37075, Zhao, lou and village people in Zhao, lou, Cheng and Xian province, aged about 68 years, swelling of calf to heel, local ulceration, no obvious curative effect in 1 more months of tumor treatment in Jinan hospitals. The traditional Chinese medicine composition provided by the embodiment 3 of the invention is used for wiping treatment, the wiping treatment is carried out for 2-3 times every day, the continuous use is carried out for 3 months, the swelling of the lower leg is completely disappeared, the pain is completely absent, the ulcer is healed, and the recurrence is avoided until now.

4. In the acute vasculitis of legs of populus, Hunan people, the age of 65 years or so, and 2017, the anti-inflammatory and analgesic traditional Chinese medicine composition obtained in the embodiment 4 of the invention is used for cleaning legs, the legs are cleaned once a day and are continuously used for one month, and the disease is cured without relapse.

5. Kangqi, Shandong province, 37075, City, Nanzhao Town, West Yao village, 68 years old, and not even stinging the face by hornet, causing severe swelling and pain of half face, the anti-inflammatory and analgesic Chinese medicinal composition obtained in the embodiment 4 of the invention is used for spraying the face three times a day, and Liang Xue is used for two days for swelling and pain elimination.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The traditional Chinese medicine composition for diminishing inflammation and relieving pain is characterized by comprising the following raw materials in parts by weight:

8-12 parts of borneol,

12-20 parts of borax, namely, borax,

8-12 parts of mirabilite,

8-12 parts of camphor, namely camphor oil,

12-20 parts of mint cream.

2. The anti-inflammatory and analgesic traditional Chinese medicine composition as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:

10 parts of borneol,

15 parts of borax, namely, sodium borate,

10 parts of mirabilite, namely 10 parts of sodium sulfate,

10 parts of camphor, namely camphor, and the like,

15 parts of mint cream.

3. The anti-inflammatory and analgesic traditional Chinese medicine composition according to claim 1 or 2, wherein the preparation method of the menthol crystal comprises the following steps: taking dried mint leaves, crushing, sieving, adding into water, distilling to obtain mint crude oil, adding the mint crude oil into an extraction kettle, extracting by adopting supercritical carbon dioxide to obtain mint oil, and cooling and crystallizing the mint oil to obtain the mint cream.

4. The anti-inflammatory and analgesic traditional Chinese medicine composition as claimed in claim 3, wherein the weight ratio of the mint leaves to the water is 1: 7-10.

5. The anti-inflammatory and analgesic traditional Chinese medicine composition as claimed in claim 3, wherein the temperature of the supercritical carbon dioxide extraction is 37 to 45 ℃, the pressure is 8.5 to 9.5MPa, and the flow rate of the carbon dioxide is 2 to 4L/min.

6. The anti-inflammatory and analgesic traditional Chinese medicine composition as claimed in claim 3, wherein the temperature of the cooling crystallization is-20 to 0 ℃.

7. The method for preparing an anti-inflammatory and analgesic Chinese medicinal composition as claimed in any one of claims 1 to 6, comprising the steps of:

8. The method for preparing a Chinese medicinal composition for diminishing inflammation and relieving pain according to claim 7, wherein in the step (2), the powder is added into cold boiled water and soaked for 5-10 days.

9. The preparation method of the anti-inflammatory and analgesic traditional Chinese medicine composition as claimed in claim 7, wherein in the step (2), the weight ratio of the powder to the cold boiled water is 1: 300-350.

10. The use of the anti-inflammatory analgesic composition of any one of claims 1 to 6 for the preparation of a medicament for the treatment of mosquito bites.