CN111329921A

CN111329921A - Traditional Chinese medicine composition for treating arthralgia and myalgia as well as medicine, preparation method and application thereof

Info

Publication number: CN111329921A
Application number: CN202010337289.1A
Authority: CN
Inventors: 罗宗坤
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-26
Filing date: 2020-04-26
Publication date: 2020-06-26

Abstract

The invention discloses a traditional Chinese medicine composition for treating arthralgia and myalgia, a medicine thereof, a preparation method and application thereof, wherein the traditional Chinese medicine composition for treating the arthralgia and myalgia comprises the following raw material components: 90-110 parts of achyranthes bidentata, 50-70 parts of cassia twig, 40-60 parts of eucommia ulmoides, 20-40 parts of asarum, 130 parts of lycopodium clavatum, 50-70 parts of kadsura coccinea, 30-50 parts of morinda officinalis, 90-110 parts of philippine flemingia root and 120 parts of Chinese lobelia. The traditional Chinese medicine composition for treating arthralgia and myalgia, disclosed by the invention, has the effects of activating blood and dissolving stasis, strengthening muscles and bones, dispelling wind and removing dampness, and dredging collaterals and relieving pain, is suitable for various arthralgia and myalgia, and is remarkable in treatment effect, high in cure rate and not easy to relapse after healing. The invention has the advantages of easily obtained raw materials, simple preparation method, safety and no toxic or side effect.

Description

Traditional Chinese medicine composition for treating arthralgia and myalgia as well as medicine, preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating arthralgia and myalgia, a medicine thereof, a preparation method and application thereof.

Background

Pain in the neck, shoulder, waist and leg is a group of diseases mainly caused by chronic strain and aseptic inflammation and mainly caused by pain, swelling and even limited function of the affected part. Common diseases include: cervical spondylosis, scapulohumeral periarthritis, tenosynovitis, lumbar intervertebral disc prolapse, lumbar muscle strain, and hyperosteogeny.

Neck, shoulder, waist and leg pain is well caused by middle-aged and elderly people and physical workers, but with the gradual acceleration of modern life rhythm, the people suffering from the pain are gradually younger and more popular. When a user drives a car for a long time, plays mobile phones, computers, air conditioners and the like, the actions can cause pain in neck, shoulder, waist and legs, and once the pain in neck, shoulder, waist and legs occurs, the pain can be relieved, so that the living, working, learning and other aspects of people are affected.

The existing medicines for treating the diseases are more, the western medicine treatment method mainly comprises oral anti-inflammatory analgesic medicines, operations and the like, the treatment side effect is large, the treatment cost is high, and the diseases can relapse after treatment and are difficult to radically cure. The traditional Chinese medicine has unique advantages in the aspect of treating chronic strain, has small treatment side effect, and can achieve the purpose of radical treatment, but the compatibility of the existing traditional Chinese medicine is still deficient, so that the traditional Chinese medicine has slow effect, and even cannot achieve the expected treatment effect.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine solution which has a remarkable treatment effect on various arthralgia and myalgia and takes effect quickly, so as to solve the problems in the prior art.

The technical scheme of the invention is as follows:

a traditional Chinese medicine composition for treating arthralgia and myalgia comprises the following raw materials in parts by weight:

90-110 parts of achyranthes bidentata, 50-70 parts of cassia twig, 40-60 parts of eucommia ulmoides, 20-40 parts of asarum, 130 parts of lycopodium clavatum, 50-70 parts of kadsura coccinea, 30-50 parts of morinda officinalis, 90-110 parts of philippine flemingia root and 120 parts of Chinese lobelia.

Preferably, the traditional Chinese medicine composition for treating arthralgia and myalgia comprises the following raw materials in parts by weight:

100 parts of achyranthes, 60 parts of cassia twig, 50 parts of eucommia bark, 30 parts of asarum, 120 parts of lycopodium clavatum, 60 parts of black tiger, 40 parts of morinda officinalis, 100 parts of philippine flemingia root and 110 parts of Chinese lobelia.

Niu xi is bitter and sour in taste and neutral in nature. Promoting blood circulation, dispelling blood stasis, nourishing liver and kidney, strengthening tendons and bones, inducing diuresis, treating stranguria, and drawing blood downward. Modern pharmacological research shows that the achyranthes bidentata wine has obvious inhibition effect on right metatarsal swelling of formaldehyde rats, obvious antagonism effect on formaldehyde-induced pain of mice and capability of relieving egg white foot inflammation of the rats.

Gui Zhi is pungent and sweet in flavor and warm in nature. Induce sweating to relieve exterior syndrome, dispel cold to alleviate pain, activate yang to regulate qi. Can be used for treating common cold due to wind-cold, pain due to cold accumulation and blood stagnation, phlegm retention, water retention syndrome, and palpitation. Modern pharmacological research shows that the alcohol extract of cassia twig has an inhibiting effect on the acetic acid writhing reaction of mice.

Du Zhong is sweet in flavor and warm in nature. Tonify liver and kidney, strengthen tendons and bones, and prevent miscarriage. Modern pharmacological research shows that the composition contains pinoresinol diglucoside, D-eugenol, eucommia ulmoides glycosides, eucommia ulmoides oliv A, erythro-dihydroxy dehydro-dibastinol and other components. Has blood pressure lowering effect; enhancing the immune function of the organism; affecting pituitary-adrenal system function; has inhibitory effect on isolated uterus; has diuretic effect; has obvious analgesic and anti-inflammatory effects. Pharmacological experiments show that the water extract and the alcohol extract of the bark and the leaf have the functions of acute blood pressure reduction and blood vessel dilatation.

Asarum herb, wild ginger, pungent in flavor and warm in nature. It enters heart, lung and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifices, warming lung, and eliminating phlegm. Modern pharmacological research shows that the Chinese herbal medicine mainly contains volatile oil (the whole herb contains 2.39% -3.80%). The asarum volatile oil has obvious effect of resisting physical or chemical pain reaction of animals. Can inhibit exudation, leukocyte migration and granulation tissue hyperplasia during inflammation. Has obvious inhibiting effect on ankle joint swelling of rats caused by formaldehyde, carrageenan, yeast and egg white, ear swelling of mice caused by croton oil, capillary permeability increase caused by histamine or prostaglandin E, leukocyte migration caused by carrageenan injection of rats and granuloma hyperplasia of rats, and can reduce histamine content in inflammatory tissues and exudates. Has anti-inflammatory effect on normal and excised adrenal gland rats. In addition, the water and ethanol extracts of asarum reduce the total allergic medium release of immediate type allergy. The asarum emulsion can be administered by intragastric administration to mice to treat thymus gland atrophy, spleen index decrease, T cell number and hemolytic plaque number decrease.

Pine tendon and vine, slightly bitter taste and cool nature. Dispel wind and remove dampness, relax tendons and activate collaterals, and relieve swelling and pain. Modern pharmacological research shows that the compound has antidiabetic activity, antitubercular activity and antibacterial activity.

Black tiger, pungent, slightly bitter and warm in nature. Promoting qi circulation, relieving pain, removing blood stasis, and dredging collaterals. Major gastric and duodenal ulcers; chronic gastritis; acute gastroenteritis; rheumatic arthralgia; traumatic injury; fracture of the bone; dysmenorrhea; postpartum abdominal pain due to blood stasis; hernia pain. Modern pharmacological research shows that the ethanol extract of the root has analgesic and anti-inflammatory effects. The crystal I obtained from the root is named as 3-methoxy-4-hydroxy-3 ', 4' -methylenedioxy lignan, and preliminary pharmacological tests prove that the crystal I has certain sedative and anti-inflammatory effects.

Morinda officinalis, pungent and sweet in flavor, slightly warm in nature. It enters kidney meridian. Tonify kidney, strengthen yang, dispel wind and remove dampness. Recent researches show that morinda officinalis has various pharmacological effects, such as anti-aging, immunity enhancing, influence on endocrine system, hematopoiesis promoting, etc.

Qianjin, sweet and pungent in flavor and warm in nature. Dispel wind, remove dampness, remove blood stasis and remove toxicity. It is indicated for wind-damp arthralgia, chronic nephritis, traumatic injury, abscess, swelling and tonsillitis. Modern pharmacological research shows that the product has the effects of relieving pain, resisting inflammation, enhancing immunity, resisting fatigue, resisting anoxia, etc.

The Chinese lobelia herb is pungent in taste, mild in nature, capable of clearing away heat and toxic materials, and capable of inducing diuresis to reduce edema, and is used for treating carbuncle, furuncle, snake and insect bite, tympanites and edema, damp-heat jaundice, eczema and eczema.

The traditional Chinese medicine composition has the effects of promoting blood circulation, removing blood stasis, strengthening muscles and bones, dispelling wind, promoting diuresis, removing blood stasis and detoxifying, and can enhance the wind-dispelling and dampness-removing effects of philippine flemingia root by assisting with the caulis tinosporae and the morinda officinalis, and has the effects of cassia twig, the asarum, dispelling cold, expelling wind and relieving pain, the kadsura coccinea is used for promoting qi circulation, removing blood stasis and dredging collaterals, and the Chinese lobelia is used for clearing heat, detoxifying and reducing swelling. The composition of the invention is a formula matched with each other, can achieve better curative effects of promoting blood circulation to remove blood stasis, strengthening muscles and bones, dispelling wind and removing dampness, and dredging collaterals and relieving pain, and is suitable for the following diseases: 1. pain in neck, shoulder, waist and leg, soft tissue injury, scapulohumeral periarthritis pain, old pain, osteoporosis and traumatic injury; 2. pain and discomfort caused by cervical, shoulder and lumbar hyperosteogeny, protrusion of intervertebral disc, swelling, bony spur and the like, and postoperative pain repair and treatment effects are obvious, and the disease is not easy to relapse after healing; 3. the treatment of the ankylosing spondylitis has obvious effect of relieving pain and stiffness discomfort.

By analyzing the modern pharmacological action of each medicament in the composition, the compatibility of the medicaments has stronger analgesic and anti-inflammatory effects, so that the aseptic inflammation of parenchyma such as fascia, muscle, tendon, ligament and the like which cause the symptoms such as neck, shoulder, waist and knee pain, stiffness, restricted movement, weakness and the like can be effectively relieved. The traditional Chinese medicine composition has a good treatment effect on various common arthralgia and myalgia, has a remarkable effect on neck, shoulder, waist and leg pains, soft tissue injuries and scapulohumeral periarthritis pains, and has a cure rate of over 90%.

The traditional Chinese medicine composition for treating arthralgia and myalgia can be prepared into various orally taken or externally applied medicines suitable for medicine with pharmaceutically acceptable carriers for treating the pain of bone fracture. Preferably, the wine is a topical wine.

The invention also provides a method for preparing a medicinal liquor from the traditional Chinese medicine composition for treating arthralgia and myalgia, which comprises the following steps:

(1) weighing the raw materials according to the parts by weight for later use;

(2) putting the raw materials and wine in a closed container, fully soaking, stirring regularly, filtering to obtain supernatant, and squeezing the residue to obtain squeezed liquid; mixing the supernatant and the squeezed solution.

Preferably, in the step (2), the wine is pure grain liquor, and the degree of the pure grain liquor is more than 50 degrees.

Preferably, in the step (2), the mass ratio of the sum of the raw materials to the wine is 1-1.5: 1.

Preferably, in the step (2), the soaking temperature is 18 +/-2 ℃, the soaking time is 80-100 days, and the stirring frequency is once every ten days.

The invention has the beneficial effects that:

the traditional Chinese medicine composition for treating arthralgia and myalgia, disclosed by the invention, is prepared by taking achyranthes bidentata, cassia twig, eucommia ulmoides, asarum, caulis tinosporae, black tiger, morinda officinalis, philippine flemingia root and Chinese lobelia as raw materials and reasonably matching, and the finally prepared medicine can achieve better curative effects of promoting blood circulation to remove blood stasis, strengthening bones and muscles, dispelling wind and removing dampness, and dredging collaterals and relieving pain, and is suitable for the following symptoms: 1. neck, shoulder, waist and leg pain, soft tissue injury and scapulohumeral periarthritis pain, the cure rate can reach more than 90%, old pain, osteoporosis and traumatic injury are effectively relieved; 2. pain and discomfort caused by cervical, shoulder and lumbar hyperosteogeny, protrusion of intervertebral disc, swelling, bony spur and the like, and postoperative pain repair and treatment effects are obvious, and the disease is not easy to relapse after healing; 3. the treatment of the ankylosing spondylitis has obvious effect of relieving pain and stiffness discomfort. The invention has the advantages of easily obtained raw materials, simple preparation method, high cure rate, safety and no toxic or side effect.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.

Example 1

The embodiment provides a medicine for treating bone injury pain, which is prepared from the following raw materials in parts by weight:

90 parts of achyranthes bidentata, 70 parts of cassia twig, 40 parts of eucommia ulmoides, 40 parts of asarum, 110 parts of lycopodium clavatum, 70 parts of black tiger, 30 parts of morinda officinalis, 110 parts of philippine flemingia root and 100 parts of Chinese lobelia.

The preparation method comprises the following steps: (1) weighing the raw materials according to the parts by weight for later use; (2) putting the raw materials and 50 ° pure grain liquor (the total of the raw materials: 1) in a sealed container, soaking at 18 deg.C, stirring once every ten days, filtering to obtain supernatant, squeezing the residue to obtain squeezed solution; mixing the supernatant and the squeezed solution.

Example 2

110 parts of achyranthes, 50 parts of cassia twig, 60 parts of eucommia bark, 20 parts of asarum, 130 parts of lycopodium clavatum, 50 parts of black tiger, 50 parts of morinda officinalis, 90 parts of philippine flemingia root and 120 parts of Chinese lobelia.

The preparation method comprises the following steps: (1) weighing the raw materials according to the parts by weight for later use; (2) placing the raw materials and 50 ° pure grain Chinese liquor (total amount of raw materials: 1.5:1) in a sealed container, soaking at 18 deg.C, stirring once every ten days, filtering to obtain supernatant after soaking for 100 days, and squeezing the residue to obtain squeezed solution; mixing the supernatant and the squeezed solution.

Example 3

The preparation method comprises the following steps: (1) weighing the raw materials according to the parts by weight for later use; (2) placing the raw materials and 50 ° pure grain Chinese liquor (total amount of raw materials: 1.34:1) in a sealed container, soaking at 18 deg.C, stirring once every ten days, filtering to obtain supernatant after soaking for 90 days, and squeezing the residue to obtain squeezed solution; mixing the supernatant and the squeezed solution.

Comparative example 1

The difference from the example 3 is only that safflower is used for replacing achyranthes root, and concretely, the comparative example is prepared by the following raw materials in parts by weight:

100 parts of safflower, 60 parts of cassia twig, 50 parts of eucommia bark, 30 parts of asarum, 120 parts of lycopodium clavatum, 60 parts of black tiger, 40 parts of morinda officinalis, 100 parts of philippine flemingia root and 110 parts of Chinese lobelia.

Comparative example 2

The difference from the example 3 is only that the Chinese lobelia is removed, and specifically, the comparative example is prepared from the following raw materials in parts by weight:

100 parts of achyranthes bidentata, 60 parts of cassia twig, 50 parts of eucommia ulmoides, 30 parts of asarum, 120 parts of caulis tinosporae, 60 parts of black tiger, 40 parts of morinda officinalis and 210 parts of philippine flemingia root.

Study of clinical therapeutic Effect

1. Case selection and grouping: the clinical effect observation of 168 cervical spondylosis patients is randomly carried out, all the patients have pain with different degrees in the local part and limited movement, and degenerative changes are shown by CT. All patients were randomly divided into control group, example 3 group, comparative example 1 group and comparative example 2 group, each of which had 42 cases, wherein the control group had a male-female ratio of 20:22, mean age (35.5 ± 4.8) years, VAS pain score (7.21 ± 1.55); example 3 the group had a male to female ratio of 21:21, mean age (34.2 + -5.5) years, VAS pain score (7.13 + -1.46); comparative example 1 the group had a male to female ratio of 21:21, mean age (35.8 + -5.7) years, VAS pain score (7.17 + -1.32); comparative example 2 the male to female ratio was 20:22, mean age (35.0 + -4.1) years, VAS pain score (7.29 + -1.82). The groups were comparable with no significant differences in sex ratio, age, VAS pain score (P > 0.05).

2. The treatment method comprises the following steps: the embodiment and the comparative group are respectively provided with corresponding medicine external application and low-frequency electric wave therapeutic apparatus treatment, and the control group is provided with sitalin cream external application and low-frequency electric wave therapeutic apparatus treatment, specifically, the medicine is firstly and uniformly applied locally, then the low-frequency electric wave therapeutic apparatus treatment is carried out, the first treatment lasts for 90min, the auxiliary medicine is absorbed every 60min later, 1 time/d is carried out, 3d lasts for 1 treatment course, and 3 treatment courses are continuously carried out.

3. The evaluation standard of the curative effect is as follows: the effect is shown: the VAS pain score decreased by 2 points and more; the method has the following advantages: a 1 point decrease in VAS pain score; and (4) invalidation: the VAS pain score decreased by less than 1 point.

4. The therapeutic effect is shown in table 1:

TABLE 1 comparison of the therapeutic effects of the groups

	Number of examples	Show effect	Is effective	Invalidation	The total effective rate%
						Control group	42	15(35.71)	22(52.38)	5(11.9)	88.10％
EXAMPLE 1 group	42	22(52.38)	18(42.86)	2(4.76)	95.24％
						Comparative example 1 group	42	18(42.86)	21(50)	3(7.14)	92.86％
Comparative example 2 group	42	17(40.48)	20(47.62)	5(11.90)	88.10％

The results show that the effective rate of the group of example 1 of the invention is 52.38%, the effective rate is 42.86%, the total effective rate is 95.24%, the groups of comparative example 1 are respectively 42.86%, 50% and 92.86%, the groups of comparative example 2 are respectively 40.48%, 47.62% and 88.10%, and the control groups are respectively 35.71%, 52.38% and 88.10%, so that the traditional Chinese medicine composition is obviously superior to the therapeutic effects of the comparative example composition and the commercially available medicines in the aspect of treating cervical spondylosis, and the curative effect of the composition is definite and the therapeutic effect is obvious.

Typical cases are:

1. cen Chi, Man, 66 years old. In 3 months in 2019, sudden low back pain is not dynamic, the patient cannot stand and walk, the patient paralyzes in bed, then the patient goes to a hospital for examination immediately, the CT waist 3/4/5 is prominent and proliferated, and the patient is hospitalized in the hospital, treated by acupuncture, massage, Chinese and western medicine combination, and discharged in half a month after local injection and other ineffective treatments. Then the medicine of the invention is adopted for treatment, and the treatment method comprises the following steps: the medicated wine prepared in the embodiment 3 is externally applied to the skin, and a low-frequency electric wave therapeutic apparatus is used for assisting, so that the medicated wine can quickly permeate to the affected part of the waist, the effect is not obvious in the first 90 minutes, the effect is very obvious in the second 60 minutes, the affected part can gradually walk by oneself and normally move, the pain completely disappears after the third treatment, and the pain does not relapse until 10 days are maintained.

2. Yang, woman, age 87. The cervical vertebra pain, the lumbar pain, the hand pain and the foot pain of people in Futang town of Lianhanshan county in Qingyuan city for 20 years or more, the people with hand pain and foot pain suddenly sit down for 29 months in 2018 and cannot get up immediately, and the people go to a hospital for examination and diagnosis: rheumatism rheumatoid arthritis, cervical spondylosis and lumbar hyperplasia, deformation and adhesion of toes, walking with a crutch, hospitalization for 14 days, acupuncture, massage and invalid discharge in combination of traditional Chinese and western medicine, and then the medicine is adopted for treatment, wherein the treatment method comprises the following steps: the medicated wine prepared in the example 3 is externally applied to the skin, and is supplemented with a low-frequency electric wave therapeutic apparatus, the first time lasts for 90 minutes, the second time lasts for 60 minutes, the third time is continuously conditioned for three times, the pain and numbness are reduced by half, the toe heads are not adhered, the treatment is continuously carried out for five times, the pain and numbness are completely eliminated, and the subsequent one-month conditioning is carried out for one or two times to achieve the consolidation effect. No recurrence has occurred so far.

3. Luo Zhi, male, age 75. Sudden waist pain accompanied by foot numbness and hand numbness in 99 years, and CT examination in a national hospital in Lian mountain county shows that: 1. degenerative changes of the cervical spine, cervical spine hyperosteogeny, herniated disc of the cervical 3/4/6/7, (central type), with calcification of the posterior ligaments, deformation of the intervertebral disc of the cervical spine 5/6/7; 2. lumbar degenerative disease, lumbar hyperosteogeny, bulging and herniated lumbar 4/5 sacral 1 disc (central type); 3. the abdominal aorta is subject to multiple calcifications, suggesting atherosclerosis. The medicine is used for treatment, and the treatment method comprises the following steps: the medicated wine prepared in the embodiment 3 is externally applied to the skin, a low-frequency electric wave therapeutic apparatus is used for 90 minutes for the first time, then the medicated wine is continuously treated for about 10 times for 60 minutes each time, the symptoms of waist pain and hand and foot numbness are completely eliminated, the medicated wine is conditioned twice in a half year in the middle, the medicated wine does not relapse until now, 10 and 20 days in 2019, 5 kilometers in international cross-country marathon ladder challenge, 200 players participate in the game, and the average age is 25-55, so that the first 10 players are obtained.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. A traditional Chinese medicine composition for treating arthralgia and myalgia is characterized by comprising the following raw materials in parts by weight:

2. The traditional Chinese medicine composition for treating arthralgia and myalgia as claimed in claim 1, wherein the raw materials comprise, by weight:

3. A medicament for treating bone injury pain, which is characterized in that the medicament for treating bone injury pain consists of the traditional Chinese medicine composition for treating bone and muscle pain in claim 1 and a pharmaceutically acceptable carrier.

4. The medicament for treating bone injury pain according to claim 3, wherein the formulation of the medicament for treating bone injury pain is an external formulation suitable for pharmaceutical use.

5. The medicament for treating bone injury pain according to claim 4, wherein the dosage form of the medicament for treating bone injury pain is medicated wine.

6. The process for producing a liquor according to claim 5, which comprises the steps of:

(1) weighing the raw materials according to the parts by weight for later use;

7. The preparation method according to claim 6, wherein in the step (2), the wine is pure grain liquor, and the degree of the pure grain liquor is more than 50 degrees.

8. The method according to claim 6, wherein in the step (2), the mass ratio of the total of the raw materials to the wine is 1-1.5: 1.

9. The method according to claim 6, wherein in the step (2), the temperature of the soaking is 18 ± 2 ℃, the time of the soaking is 80-100 days, and the frequency of the stirring is once every ten days.

10. The use of the Chinese medicinal composition for the treatment of arthralgia and myalgia as claimed in any one of claims 1-2 in the preparation of medicament for the treatment of neck, shoulder, waist and leg pain, traumatic injury, and ankylosing spondylitis.