CN104825713A - Traditional Chinese medicine composition for treating osteomyelitis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating osteomyelitis. The traditional Chinese medicine composition comprises an internal medicine and a medicine for external application, wherein the internal medicine takes rostrate lepidogrammitis herb, african marigold leaf, grossedentate clematis root, purple senecio, flower buds of panax notoginseng, david gentian herb, slender-spike gouania stem and leaf, Japanese spicebush bark, serrate glorybower herb, Chinese violet, dandelion and berberidis radix as monarch and ministerial drugs; and coptis chinensis, honeysuckle, goat bones, Manis pentadactyla, centipede, dragon's blood, dysosma versipellis and uniflower swisscentaury root are taken as adjuvants. The medicine for external application is prepared from david gentian herb, lithargite, cutch, Momordica grosvenori root, lowigite, leaves of panax notoginseng, roseleaf, oldenlandia diffusa, Chinese actinidia root, marigold root, Chinese violet, dragon's blood, centipede and serrate glorybower herb. The traditional Chinese medicine composition disclosed by the invention has the effects of expelling pus and eliminating corrosive effects, the sinus tract and necrotizing bones are injured from the interior to exterior, and fester, necrotizing bones and inactive tissues are eliminated, so that the granulation is bright red so as to form fresh wounds. The traditional Chinese medicine preparation disclosed by the invention has a unique curative effect on treatment of fluorosis of bone, and pain of patients is fundamentally relieved.

Description

One treats myelitic Chinese medicine composition

Technical field

The present invention relates to the field of Chinese medicines, one treats myelitic Chinese medicine composition specifically.

Background technology

Osteomyelitis is diffused into bone or peripheral blood vessel, sacred disease by antibacterial by blood, or diabetes, open fracture and the infectious disease of bone caused by injection or drug administration hormone.Its symptom of osteomyelitis (co) is widely different, child, and rapid onset.Osteodynia, difficulty in walking, generates heat or feels cold, and local is red and swollen.Adult, morbidity is relatively slow, heating, shiver with cold, partial gall etc.Acute osteomyelitis rapid onset, with pain, heating, ankylosis.Usually ulcer etc. after traumatic skin breakage, operation or wound is secondary to.Chronic osteomyelitis is slowly shown effect or in shape of hiding.Osteomyelitis recurrence before may being, its symptom comprises heating, pain, redness or local and suppurates.Bones of limbs two ends are subject to invade most, are the most common especially with hip joint.

Clinical manifestation: the diseases associated with inflammation that osteomyelitis refers to suppurative bacterium infection bone marrow, cortical bone and periosteum and causes, majority is caused by haematogenous, also manyly to be caused by wound or postoperative infection, how enter blood by the suppuration bacterium of furuncle carbuncle or other focuses and reach osseous tissue.Bones of limbs two ends are subject to invade most, are the most common especially with hip joint.Common clinically have recurrent exerbation, has a strong impact on physical and mental health and work capacity.High heat, local pain during acute osteomyelitis onset, have diabrosis, suppurate, have sequestrum or cavity to be formed when transferring chronic osteomyelitis to.The normal threat to life of patient with severe symptoms, sometimes has to take the emergency approach of amputation, causes patient's lifelong disability.

Osteomyelitis traditional Chinese medical science name is pyogenic infection of the bone, among the peoplely to be commonly called as " gagger tumor ", first treatment osteomyelitis want toxin expelling, with the Chinese medicine with evacuation of pus, corrosiveness, from-inner-to-outer destroys sinus tract and sequestrum, promoting that pus, sequestrum and debility tissue are discharged, make the fresh wound surface of the scarlet formation of granulation, is that the traditional Chinese medical science is to myelitic treatment basis.Two want granulation promoting, the myelitic treatment of this respect mainly adopt there is putrefaction-removing granulation-promoting, the Chinese medicine of sore of putting on flesh effect, promote bone marrow, sclerotin, muscle and skin tissue regeneration and reparation from inside to outside, finally make Dou Kou heal.

Current therapies: (1) has pain person, gives appropriate nonsteroidal analgesics, as aspirin, also can give indomethacin.(2) there is skeleton deformity person, should locally fix or row orthomorphia, prevent deformity aggravation.(3) once occur that canalis spinalis blocks or paraplegia, should perform the operation early, removing nerve compression.Western medicine often side effect is large, and effect is not so good as Chinese medicine administration and has no side effect, instant effect.

Summary of the invention

The object of this invention is to provide one and treat myelitic Chinese medicine composition.

One of the present invention treats myelitic Chinese medicine composition, comprises oral medicine and application compress, thoroughly cures osteomyelitis from inside to outside.The present invention is configured by clinic tests and repeated verification, meets the theory of Chinese medicine.The medicine toxin expelling evacuation of pus that oral medicine is the monarch and his subjects with Herba Lepidogrammitis rostratae, Folium Tagetis Erectae, Radix Clematidis Argentilucidae, Herba Senecionis nudicaulis, flower of Radix Notoginseng, Herba gentianae davidi, Caulis et Folium (Gouaniae Leptostachyae), Cortex Linderae Obtusilobae, Herba Clerodendri Serrati, Herba Violae, Herba Taraxaci, Radix Berberidis, heat-clearing and toxic substances removing, promoting flow of QI and blood; With Rhizoma Coptidis, Flos Lonicerae, Os Caprae seu Ovis, Squama Manis, Scolopendra, Sanguis Draxonis, Radix et Rhizoma Dysosmatis, the medicine of Radix Rhapontici for assisting a ruler in governing a country, strengthen effect of the medicine of the monarch and his subjects, guide all medicines to go directly disease institute, all medicines share the effect with heat-clearing and toxic substances removing, toxin expelling evacuation of pus, dispelling wind dredging collateral, bone and muscle strengthening, liver and kidney tonifying, compensate qi and blood.Medicine for external use is with Herba gentianae davidi, Lithargyrum, catechu, Momordica grosvenori root, fibroferritum, Folium Notoginseng, Folium rosae multiflorae, Herba Hedyotidis Diffusae, Radix Actinidiae Chinensis, Flos Tagetis Erectae root, Herba Violae, Sanguis Draxonis, Scolopendra, Herba Clerodendri Serrati composition.Chinese medicine composition of the present invention has the Chinese medicine of evacuation of pus, corrosiveness, and from-inner-to-outer destroys sinus tract and sequestrum, promotes that pus, sequestrum and debility tissue are discharged, makes the fresh wound surface of the scarlet formation of granulation.Chinese medicine preparation treatment skeletal fluorosis of the present invention has unique curative effect, fundamentally relieves the misery of patient.

One treats myelitic Chinese medicine composition, it is characterized in that, oral medicine is made up of the raw material of following weight portion: Herba Lepidogrammitis rostratae 10-20 part, Folium Tagetis Erectae 10-20 part, Radix Clematidis Argentilucidae 10-20 part, Herba Senecionis nudicaulis 10-20 part, flower of Radix Notoginseng 10-20 part, Herba gentianae davidi 10-20 part, Caulis et Folium (Gouaniae Leptostachyae) 10-20 part, Cortex Linderae Obtusilobae 10-20 part, Herba Clerodendri Serrati 10-20 part, Herba Violae 10-20 part, Herba Taraxaci 10-20 part, Radix Berberidis 10-20 part, Rhizoma Coptidis 1-10 part, Flos Lonicerae 1-10 part, Os Caprae seu Ovis 1-10 part, Squama Manis 1-10 part, Scolopendra 1-10 part, Sanguis Draxonis 1-10 part, Radix et Rhizoma Dysosmatis 1-10 part, Radix Rhapontici 1-10 part.

Application compress are made up of the raw material of following weight portion: Herba gentianae davidi 20-30 part, Lithargyrum 1-10 part, catechu 20-30 part, Momordica grosvenori root 20-30 part, fibroferritum 1-10 part, Folium Notoginseng 20-30 part, Folium rosae multiflorae 20-30 part, Herba Hedyotidis Diffusae 20-30 part, Radix Actinidiae Chinensis 20-30 part, Flos Tagetis Erectae root 20-30 part, Herba Violae 20-30 part, Sanguis Draxonis 20-30 part, Scolopendra 20-30 part, Herba Clerodendri Serrati 20-30 part.

One treats myelitic Chinese medicine composition, it is characterized in that, oral medicine is made up of the raw material of following weight portion: Herba Lepidogrammitis rostratae 12-18 part, Folium Tagetis Erectae 12-18 part, Radix Clematidis Argentilucidae 12-18 part, Herba Senecionis nudicaulis 12-18 part, flower of Radix Notoginseng 12-18 part, Herba gentianae davidi 12-18 part, Caulis et Folium (Gouaniae Leptostachyae) 12-18 part, Cortex Linderae Obtusilobae 12-18 part, Herba Clerodendri Serrati 12-18 part, Herba Violae 12-18 part, Herba Taraxaci 12-18 part, Radix Berberidis 12-18 part, Rhizoma Coptidis 2-8 part, Flos Lonicerae 2-8 part, Os Caprae seu Ovis 2-8 part, Squama Manis 2-8 part, Scolopendra 2-8 part, Sanguis Draxonis 2-8 part, Radix et Rhizoma Dysosmatis 2-8 part, Radix Rhapontici 2-8 part.

Application compress are made up of the raw material of following weight portion: Herba gentianae davidi 22-28 part, Lithargyrum 2-8 part, catechu 22-28 part, Momordica grosvenori root 22-28 part, fibroferritum 2-8 part, Folium Notoginseng 22-28 part, Folium rosae multiflorae 22-28 part, Herba Hedyotidis Diffusae 22-28 part, Radix Actinidiae Chinensis 22-28 part, Flos Tagetis Erectae root 22-28 part, Herba Violae 22-28 part, Sanguis Draxonis 22-28 part, Scolopendra 22-28 part, Herba Clerodendri Serrati 22-28 part.

One treats myelitic Chinese medicine composition, it is characterized in that, oral medicine is made up of the raw material of following weight portion: Herba Lepidogrammitis rostratae 15 parts, Folium Tagetis Erectae 15 parts, Radix Clematidis Argentilucidae 15 parts, Herba Senecionis nudicaulis 15 parts, flower of Radix Notoginseng 15 parts, Herba gentianae davidi 15 parts, Caulis et Folium (Gouaniae Leptostachyae) 15 parts, Cortex Linderae Obtusilobae 15 parts, Herba Clerodendri Serrati 15 parts, Herba Violae 15 parts, Herba Taraxaci 15 parts, Radix Berberidis 15 parts, Rhizoma Coptidis 5 parts, Flos Lonicerae 5 parts, Os Caprae seu Ovis 5 parts, Squama Manis 5 parts, Scolopendra 5 parts, Sanguis Draxonis 5 parts, Radix et Rhizoma Dysosmatis 5 parts, Radix Rhapontici 5 parts.

Application compress are made up of the raw material of following weight portion: Herba gentianae davidi 25 parts, Lithargyrum 5 parts, 25 parts, catechu, Momordica grosvenori root 25 parts, fibroferritum 5 parts, Folium Notoginseng 25 parts, Folium rosae multiflorae 25 parts, Herba Hedyotidis Diffusae 25 parts, Radix Actinidiae Chinensis 25 parts, Flos Tagetis Erectae root 25 parts, Herba Violae 25 parts, Sanguis Draxonis 25 parts, Scolopendra 25 parts, Herba Clerodendri Serrati 25 parts.

One treats myelitic Chinese medicine composition, it is characterized in that, the dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

(1) by formula proportion by Os Caprae seu Ovis, Squama Manis, that Scolopendra is ground into 300-400 order powder is for subsequent use;

(2) by formula proportion, surplus stock medicine is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, add powder for subsequent use, filter through 80-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

One treats myelitic Chinese medicine composition, it is characterized in that, the dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

One treats myelitic Chinese medicine composition, it is characterized in that, application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.

The present invention relates to pharmacology and the property of medicine of Chinese medicine:

Herba Lepidogrammitis rostratae:

[nature and flavor] micro-hardship; Sweet; Flat

[return through] lung; Small intestine meridian

[function cures mainly] clearing away heat and promoting diuresis; Cough-relieving; Relieving restlessness; Removing toxic substances and promoting subsidence of swelling.Main uroschesis; Drench the puckery pain of drop; Heat syndrome cough; Vexed; Skin infection swells and ache; Traumatic injury.

Folium Tagetis Erectae: sweet, cold.For carbuncle, skin ulcer, furuncle, furuncle, innominate toxic swelling.

Radix Clematidis Argentilucidae:

[nature and flavor] acrid in the mouth, warm in nature.

[function cures mainly-Radix Clematidis Argentilucidae effect] promoting flow of QI and blood, wind-damp dispelling, pain relieving.

Control traumatic injury, pain due to blood stasis, rheumatic bones and muscles pain, numb limbs and tense tendons.

Caulis et Folium (Gouaniae Leptostachyae):

[meridian distribution of property and flavor] is sour, puckery, cool.

[function cures mainly] removing pathogenic heat from blood and toxic substance from the body, relaxing muscles and tendons and activating QI and blood in the collateral.For numb limbs and tense tendons; Burn and scald is controlled in external, skin infection.

Cortex Linderae Obtusilobae:

Cortex Linderae Obtusilobae is the bark of canella Cortex Linderae Obtusilobae, invigorate blood circulation, relaxing muscles and tendons, dissipating blood stasis, the effect such as detumescence.

[ nature and flavor] " Shaanxi Chinese herbal medicine ": " acrid in the mouth, warm in nature."

[ function cures mainly] " Shaanxi Chinese herbal medicine ": " relaxing muscles and tendons to promote blood circulation, dissipating blood stasis for subsidence of swelling.Control traumatic injury, swelling and pain due to blood stasis."

Herba Clerodendri Serrati:

[meridian distribution of property and flavor]: Xin Gan, temperature.Return spleen; Kidney channel

[function cures mainly] synthetism, pain relieving, preventing the attack (or recurrence) of malaria.Control fracture, traumatic injury, rheumatalgia, malaria.Clearing away heat-damp and promoting diuresis; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main hygropyretic dysentery; Stranguria; Beriberoid pyretic arthralgia; Dysmenorrhea due to blood stasis; Traumatic injury; Laryngopharynx swelling and pain; Swollen ulcer drug; Urticaria; Malaria

1. " register planted by Guangxi medicine ": refute bone, parasite killing, stomach invigorating, clearing away heart-fire, strengthening bone and muscle.Treating malaria disease, dysentery, headache, ophthalmia, traumatic injury.

2. " Guizhou medical herbs ": invigorating spleen to remove dampness, tonify deficiency benefit is damaged.Control weak edema, impairment caused by overstrain.

3. " mountain of papers Chinese herbal medicine ": bone-setting pain stopping, heat-clearing and toxic substances removing.Control fracture, traumatic injury, rheumatalgia, innominate toxic swelling.

Herba Senecionis nudicaulis:

[nature and flavor]: Gan Danliang.

[function cures mainly] 1, exogenous high fever, heatstroke is had a fever; 2, cough due to lung-heat; 3, treating swelling and pain by traumatic injury.Heat-clearing and toxic substances removing, moistens dryness and relieve cough, dissipating blood stasis for subsidence of swelling

Flower of Radix Notoginseng:

[nature and flavor] are cool in nature, sweet in the mouth, micro-hardship.

[function] is mainly used in that heat clearing away, removing toxic substances, removing heat from blood, blood pressure lowering, tune fat, immunomodulating, blood circulation and channel invigorating, health preserving are anti-ageing, the active ingredient of anti-inflammatory analgesic action.There is significant suppressing the hyperactive liver, eliminate the phlegm, relieving asthma, sleeping, effect such as coronary dilating, antiallergic, eliminating toxin and beautifying the skin of easing pain.

Herba gentianae davidi:

[nature and flavor] are cool in nature, bitter in the mouth.

[function] heat-clearing and toxic substances removing, diuresis improving eyesight; Control suppurative osteomyelitis, urinary tract infection, conjunctivitis, furuncle, carbuncle.

Herba Violae:

[meridian distribution of property and flavor] bitter, acrid, cold, nontoxic; GUIXIN, Liver Channel.

[function] can be used as medicine, its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.

Herba Taraxaci:

[nature and flavor] are sweet, micro-hardship, cold.

[curing mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, upper respiratory tract infection, eye conjunctivitis, mumps, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder assists inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.

Radix Berberidis:

[nature and flavor] are bitter, cold.

[effect] heat clearing and damp drying, eliminating fire and detoxication.

Rhizoma Coptidis:

[meridian distribution of property and flavor] is bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.

[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Folium Notoginseng:

[effect]: hemostasis, detumescence, pain relieving.

[curing mainly]: control haematemesis, epistaxis, have blood in stool, traumatic hemorrhage, carbuncle skin infection.

[meridian distribution of property and flavor]: pungent, warm; " the SHENGCAO property of medicine is standby to be wanted ": " acrid in the mouth." enter liver, stomach two warp

Catechu:

[meridian distribution of property and flavor] is bitter, puckery, is slightly cold.Return lung meridian.

[function cures mainly] removing dampness promoting tissue regeneration and ulcer healing, for ulcer being unable to heal, eczema, aphtha, traumatic pain, traumatic hemorrhage.

Flos Lonicerae:

[nature and flavor] property is sweet, cold;

[function] has heat clearing away, removing toxic substances, antiinflammatory, antibacterial effect.Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer, also for anemopyretic cold, and the diseases such as bronchitis.Modern pharmacological research shows, Flos Lonicerae has the effect such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation.

The loose poison of heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, Flos Lonicerae has the effect traditional Chinese medical science such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation and thinks, Flos Lonicerae is cold in nature, sweet in the mouth, gas flat, has effect of heat-clearing and toxic substances removing, can treat the disease such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay the pathological changes effect of Respirovirus to cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Caused by the endotoxin that Flos Lonicerae preparation lumbar injection obviously can reduce bacillus pyocyaneus, the leukocyte count of rabbit declines, and deviation to the left phenomenon etc. has obvious antagonism.Flos Lonicerae compatibility Radix Scutellariae is prepared into poisoning symptom and the death that preparation obviously can alleviate bacillus pyocyaneus endotoxin caused rabbit.

Momordica grosvenori root:

[nature and flavor] are sweet, cool, enter lung;

The root of the Fructus Momordicae that [function] is smashed to pieces, spreads on affected part and can control stubborn dermatitis, and pain is swollen, furuncle etc.

Fibroferritum:

[nature and flavor] acid; Puckery; Salty; Cold; Poisonous

[return through] liver; Large intestine channel

[function cures mainly] removing toxic substances parasite killing; Sore.Main hemorrhoid complicated by anal fistula; Malignant boil; Scabies; Ting ear comes to a head

Radix Rhapontici:

[nature and flavor] " herbal classic ": " bitter in the mouth is salty, cold." " not Lu ": " Great Cold, nontoxic." " book on Chinese herbal medicine is just ": " taste is micro-salty, cold in nature, slightly poisonous.”

[return through] enters stomach, large intestine channel.

[function] heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation.

[curing mainly] swells and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.

Os Caprae seu Ovis:

[meridian distribution of property and flavor] is sweet, temperature.1. " not Lu ": " heat." 2. " Bencao Tujing ": " and temperature, flat." 3. " detailed outline ": " and spine: sweet, heat, nontoxic." " skull: sweet, flat, nontoxic." 4. " medical center bun is wanted ": " and tibia: salty, flat." enter spleen, kidney channel.

[effect] invigorating the kidney and strengthening the bones, warming middle-JIAO to stop diarrhea.Control asthenia weakness and emaciation, weakness of the waist and knees, muscles and bones spasm and pain, nebulousurine, drench pain, chronic diarrhea, chronic dysentery.

Squama Manis:

[nature and flavor] salty in the mouth; Cold nature

[return through] liver; Stomach warp

[function cures mainly] blood circulation promoting and dispersing pathogen accumulation; To stimulate the menstrual flow stimulating milk secretion; Eliminating carbuncle is burst hard.Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Agalactia; Carbuncle; Scrofula

Scolopendra:

[meridian distribution of property and flavor] acrid in the mouth, temperature; Poisonous; Return Liver Channel.

[function cures mainly] endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.

Sanguis Draxonis:

Another name: black horse Lin exhausts, sea wax, dragon's blood, wooden Sanguis Draxonis.

[meridian distribution of property and flavor]

Gan Xian is flat.Enter the heart, liver, spleen channel.

[effect] takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.

[curing mainly]

1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.

2. lump in the abdomen mass in the abdomen, breast ventral spine pain.

3. traumatic injury, congestion swells and ache.

4. traumatic hemorrhage, ulcer being unable to heal.

Radix et Rhizoma Dysosmatis:

[meridian distribution of property and flavor] is warm in nature, bitter in the mouth, pungent; Poisonous.

[function cures mainly] heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, eliminating phlegm for diminishing swelling.For carbuncle furuncle, scrofula, laryngopharynx swelling and pain, traumatic injury, venom.

Lithargyrum:

[meridian distribution of property and flavor] property is salty, pungent, flat, poisonous; Enter liver, spleen channel.

[effect] detumescence, parasite killing, convergence are anticorrosion, eliminating phlegm down to arrest convulsion, through test to multiple pathogenic dermatophytes, have inhibitory action in various degree, the blood vessel at mucosa and ulcer place can be shunk, secretion is reduced, and have the effect such as to protect from infection of antiinflammatory.

Folium rosae multiflorae:

[meridian distribution of property and flavor] puckery, flat spleen channel.

[function cures mainly] " Nanning City's medicine will ": " mash external application, promoting tissue regeneration and wound healing."

Radix Actinidiae Chinensis:

[nature and flavor] " Shaanxi Chinese herbal medicine ": " acid is micro-sweet, cool, slightly poisonous."

[function cures mainly] heat clearing away, diuresis, invigorates blood circulation, detumescence.Treating the liver is scorching, edema, traumatic injury, rheumatic arthritis, stranguria with turbid discharge, leukorrhagia, furuncle, scrofula.1. " Guizhou side's medicine among the people collection ": " diuresis, cathartic.Control ascites; External synthetism, disappear wound." 2. " Zhejiang conventional medical herbs among the people ": " stomach invigorating, invigorates blood circulation, lactogenic, antiinflammatory." 3. " Shaanxi Chinese herbal medicine ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence, anticancer.Control furuncle, scrofula."

Herba Hedyotidis Diffusae:

[meridian distribution of property and flavor] bitter but sweet flavor, warm in nature, nontoxic.Enter the heart, liver, spleen three warp.

[function cures mainly] hyoscine, has the function of heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.Cure mainly the diseases such as malignant tumor, appendicitis, hepatitis, bronchitis, tonsillitis, laryngitis, urinary system infection, pelvic inflammatory disease, adnexitis; Furuncle carbuncle, venom are controlled in external.Modern Chinese medicine is clinical is used for the treatment of the kinds cancers such as gastric cancer, the esophageal carcinoma, intestinal cancer, uterus carcinoma, nasopharyngeal carcinoma.

Flos Tagetis Erectae root: bitter, cool.Removing toxic substances and promoting subsidence of swelling.For upper respiratory tract infection, pertussis, bronchitis, eye keratitis, pharyngitis, stomatitis, toothache; Parotitis is controlled in external, mastitis, carbuncle pyogenic infections from tumour or sore.

detailed description of the invention:

Embodiment 1,

Oral medicine formula: Herba Lepidogrammitis rostratae 10g, Folium Tagetis Erectae 10g, Radix Clematidis Argentilucidae 10g, Herba Senecionis nudicaulis 10g, flower of Radix Notoginseng 10g, Herba gentianae davidi 10g, Caulis et Folium (Gouaniae Leptostachyae) 10g, Cortex Linderae Obtusilobae 10g, Herba Clerodendri Serrati 10g, Herba Violae 10g, Herba Taraxaci 10g, Radix Berberidis 10g, Rhizoma Coptidis 1g, Flos Lonicerae 1g, Os Caprae seu Ovis 1g, Squama Manis 1g, Scolopendra 1g, Sanguis Draxonis 1g, Radix et Rhizoma Dysosmatis 1g, Radix Rhapontici 1g;

The dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

Usage and dosage: one day potion divides to be taken for three times.

Application compress formula: Herba gentianae davidi 20g, Lithargyrum 1g, catechu 20g, Momordica grosvenori root 20g, fibroferritum 1g, Folium Notoginseng 20g, Folium rosae multiflorae 20g, Herba Hedyotidis Diffusae 20g, Radix Actinidiae Chinensis 20g, Flos Tagetis Erectae root 20g, Herba Violae 20g, Sanguis Draxonis 20g, Scolopendra 20g, Herba Clerodendri Serrati 20g;

Application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.

Usage and dosage: subsides in a day, smear to affected part gauze and twine.

Model case:

Zhang, readme is fallen from eminence on July 15th, 2012, cause fl comminuted fracture, suddenly deliver to local county people's hospital row " fl comminuted fracture internal fixation ", there is congestion and swelling pain in postoperative patient left thigh, also there is ulceration in operative incision position outside left thigh, stay a small amount of yellow water sample exudate, matter is rare, free from extraneous odour, arrive hospital treatment afterwards, give antiinflammatory fluid infusion (concrete medication is not quite clear), debridement, internal fixtion removal surgery and expopexy, left thigh congestion and swelling pain takes a turn for the better, but operative incision still continues to occur that ulceration is suppurated outside left thigh, continue to give process of changing dressings every day.Training checks: fl external fixer is fixed, the slight red and swollen activity of left thigh is obviously limited, outside left thigh hypomere, visible one is about 1cm, dark about about 3cm sinus tract, a small amount of pale red blood sample exudate is had in sinus tract, there is slight abnormal flavour, cicatrix surrounding skin pigmentation outside left thigh, Pi Wenlvegao.Auxiliary examination: x-ray inspection: fl hypomere fracture surgery, broken ends of fractured bone para-position, good to line, fracture line is fuzzy, fixing in place.Modern for asking further treatment, go to a doctor to my institute's Orthopaedics Clinic, outpatient service is intended " fl chronic osteomyelitis " and is hospitalized and be admitted to hospital.Give extract oral of the present invention and external application for curing after one month left thigh swelling alleviate, movable function takes a turn for the better, and sinus tract drain is unobstructed, and pus reduces gradually, and abnormal flavour disappears, cicatrix surrounding skin pigmentation outside left thigh, skin temperature no abnormality seen.Consolidate a rehabilitation in month recovery from illness afterwards.

Embodiment 2:

Oral medicine formula: Herba Lepidogrammitis rostratae 12g, Folium Tagetis Erectae 12g, Radix Clematidis Argentilucidae 12g, Herba Senecionis nudicaulis 12g, flower of Radix Notoginseng 12g, Herba gentianae davidi 12g, Caulis et Folium (Gouaniae Leptostachyae) 12g, Cortex Linderae Obtusilobae 12g, Herba Clerodendri Serrati 12g, Herba Violae 12g, Herba Taraxaci 12g, Radix Berberidis 12g, Rhizoma Coptidis 2g, Flos Lonicerae 2g, Os Caprae seu Ovis 2g, Squama Manis 2g, Scolopendra 2g, Sanguis Draxonis 2g, Radix et Rhizoma Dysosmatis 2g, Radix Rhapontici 2g;

The dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

(1) by formula proportion by Os Caprae seu Ovis, Squama Manis, that Scolopendra is ground into 300-400 order powder is for subsequent use;

(2) by formula proportion, surplus stock medicine is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, add powder for subsequent use, filter through 80-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Application compress formula: Herba gentianae davidi 22g, Lithargyrum 2g, catechu 22g, Momordica grosvenori root 22g, fibroferritum 2g, Folium Notoginseng 22g, Folium rosae multiflorae 22g, Herba Hedyotidis Diffusae 22g, Radix Actinidiae Chinensis 22g, Flos Tagetis Erectae root 22g, Herba Violae 22g, Sanguis Draxonis 22g, Scolopendra 22g, Herba Clerodendri Serrati 22g;

Application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.

Usage and dosage: subsides in a day, smear to affected part gauze and twine.

Model case: king so-and-so, 2 years front rights foot outside because of walking gall after form the large vesicle of 3cm, right sufficient little toe also forms a comparatively vesicle because of same reason, and form ulcer surface gradually, have pus to flow out, local hospital does not heal after treating a period of time.Rear ulcer surface strengthens gradually, occasionally has sequestrum to flow out, successively seeks medical advice in famous hospital of many families inside the province and still fails healing.Patient, for asking further treatment, carrys out my Out-patient Department on October 20th, 2014 and seeks medical advice, and outpatient service is intended " right foot the 5th metatarsal chronic osteomyelitis " and accepted for medical treatment and be admitted to hospital.Training checks: two upper limb and spinal column are without deformity, flexibly movable; Right lower extremity swelling, biped Varus deformity, in " strephopodia ", two lower limb muscles atrophy, right foot outside mid point has a ulcer surface diameter to be about 3cm deeply to reach osseous tissue, and ulcer surface tissue is canescence, without blood supply, pus is had to ooze out, ulcer surface surrounding skin is kermesinus, surrounding tissue swelling, and localized tenderness is obvious, right skin of foot is clammy, and right sufficient pulsation of foot dorsal artery weakens.Auxiliary examination: CR sheet shows: right foot the 5th metatarsal nearly section bone density is uneven to be increased and part bony defect, bone trabecula is disorderly, and a small amount of sclerotic bone is formed.

Give oral medicinal herb of the present invention and external application for curing was shown in after 2 months: the ulcer surface healing of right foot outside, local desiccation, skin colour is ruddy, has no swelling, and skin elasticity is normal, and local has no tenderness, right sufficient skin temperature no abnormality seen, right sufficient pulsation of foot dorsal artery no abnormality seen.

Embodiment 3, oral medicine formula: Herba Lepidogrammitis rostratae 15g, Folium Tagetis Erectae 15g, Radix Clematidis Argentilucidae 15g, Herba Senecionis nudicaulis 15g, flower of Radix Notoginseng 15g, Herba gentianae davidi 15g, Caulis et Folium (Gouaniae Leptostachyae) 15g, Cortex Linderae Obtusilobae 15g, Herba Clerodendri Serrati 15g, Herba Violae 15g, Herba Taraxaci 15g, Radix Berberidis 15g, Rhizoma Coptidis 5g, Flos Lonicerae 5g, Os Caprae seu Ovis 5g, Squama Manis 5g, Scolopendra 5g, Sanguis Draxonis 5g, Radix et Rhizoma Dysosmatis 5g, Radix Rhapontici 5g.

The dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

(1) by formula proportion by Os Caprae seu Ovis, Squama Manis, that Scolopendra is ground into 300-400 order powder is for subsequent use;

(2) by formula proportion, surplus stock medicine is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, add powder for subsequent use, filter through 80-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Application compress formula: Herba gentianae davidi 25g, Lithargyrum 5g, catechu 25g, Momordica grosvenori root 25g, fibroferritum 5g, Folium Notoginseng 25g, Folium rosae multiflorae 25g, Herba Hedyotidis Diffusae 25g, Radix Actinidiae Chinensis 25g, Flos Tagetis Erectae root 25g, Herba Violae 25g, Sanguis Draxonis 25g, Scolopendra 25g, Herba Clerodendri Serrati 25g.

Application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.

Usage and dosage: subsides in a day, smear to affected part gauze and twine.

Model case:

Liu, in about in January, 2014, occur right upper arm swelling pain because moving accidentally, occur together heat, and right side arm activity is not good enough, and medical to local commune hospital, concrete diagnosis and treatment are not quite clear, and symptom is without obvious alleviation.By local barefoot doctor's Traditional Chinese Medicine for external application treatment, swelling pain is without obvious alleviation, and local occurs that ulceration is suppurated.So to local people's hospital admission, be diagnosed as " right humerus chronic osteomyelitis ", the treatments such as underwent operative Fenestration drainage, antiinflammatory, specifically not quite clear, swelling pain remission, wound healing.Symptom is shown effect again in the near future, and pain increases the weight of, again row operative treatment, specifically not quite clear, remission, wound healing.But patient's right upper arm pain occurs that many hospital admissions are successively arrived in right upper arm swelling repeatedly, diagnosis aspect is all considered " right humerus chronic osteomyelitis ", does not do concrete treatment.Before 3 days, former second time operative site ulceration is suppurated and is occurred sinus tract.Modern for asking further treatment, go to a doctor to my institute's Orthopaedics Clinic, outpatient service is intended " right humerus chronic osteomyelitis " and is hospitalized and be admitted to hospital.Training checks: right upper arm obvious tumefaction, and tape records left upper arm week footpath 24cm, right upper arm week footpath 26cm; The visible two place's old operative scars of right upper arm, respectively have a sinus tract at two operative scar places, hole mouth size is respectively 2cmX2cm (right humerus epimere), 1cmX1cm (right lesion of lower segment of humerus), do not visit and the degree of depth because patient fears pain, have a small amount of purulence to ooze out; Affected part and around pigmentation are obvious, and Pi Wengao, local organization poor flexibility, tenderness is obvious.The activity of right upper extremity shoulder elbow joint is not good enough, give oral medicinal herb of the present invention and external application for curing was shown in after 1 month: right upper arm swelling alleviates, tape records left upper arm week footpath 24cm, right upper arm week footpath 25.5cm, ulcer surface reduces, and local drainage is unobstructed, skin temperature no abnormality seen, tenderness alleviates, and right upper extremity shoulder elbow joint movable function takes a turn for the better.Treat after 2 months: right upper arm swelling alleviates, tape records left upper arm week footpath 24cm, and right upper arm week footpath 25cm, ulcer surface is tending towards healing gradually, and minute quantity pus is drawn, skin temperature no abnormality seen, and tenderness alleviates, and right upper extremity shoulder elbow joint movable function takes a turn for the better.Treat after 4 months: right upper arm has no obvious tumefaction, tape records left upper arm week footpath 24cm, and right upper arm week footpath 24.5cm, ulcer surface heals substantially, local desiccation, skin temperature no abnormality seen, and tenderness alleviates, and right upper extremity shoulder elbow joint movable function takes a turn for the better.After treating half a year: right upper arm has no swelling, tape records left upper arm week footpath 24cm, and right upper arm week footpath 24cm, ulcer surface is formed a scab, skin temperature no abnormality seen, and skin elasticity is recovered, and has no tenderness, and right upper extremity shoulder elbow joint movable function recovers.

Embodiment 4, oral medicine formula: Herba Lepidogrammitis rostratae 18g, Folium Tagetis Erectae 18g, Radix Clematidis Argentilucidae 18g, Herba Senecionis nudicaulis 18g, flower of Radix Notoginseng 18g, Herba gentianae davidi 18g, Caulis et Folium (Gouaniae Leptostachyae) 18g, Cortex Linderae Obtusilobae 18g, Herba Clerodendri Serrati 18g, Herba Violae 18g, Herba Taraxaci 18g, Radix Berberidis 18g, Rhizoma Coptidis 8g, Flos Lonicerae 8g, Os Caprae seu Ovis 8g, Squama Manis 8g, Scolopendra 8g, Sanguis Draxonis 8g, Radix et Rhizoma Dysosmatis 8g, Radix Rhapontici 8g;

The dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

(1) by formula proportion by Os Caprae seu Ovis, Squama Manis, that Scolopendra is ground into 300-400 order powder is for subsequent use;

(2) by formula proportion, surplus stock medicine is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, add powder for subsequent use, filter through 80-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

Usage and dosage: warm water takes, 3 times/day, 3 tablets/time, 4.5g/ grain.

Application compress formula: Herba gentianae davidi 28g, Lithargyrum 8g, catechu 28g, Momordica grosvenori root 28g, fibroferritum 8g, Folium Notoginseng 28g, Folium rosae multiflorae 28g, Herba Hedyotidis Diffusae 28g, Radix Actinidiae Chinensis 28g, Flos Tagetis Erectae root 28g, Herba Violae 28g, Sanguis Draxonis 28g, Scolopendra 28g, Herba Clerodendri Serrati 28g;

Application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.

Usage and dosage: subsides in a day, smear to affected part gauze and twine.

Model case:

Patient from be set forth in 2014-01-16 walking time accidentally from eminence traumatic injury, wound after stupor, rear by people find be sent to the People's Hospital by local county 120 car, be diagnosed as: 1, craniocerebral trauma 2, whole body multiple fracture.Treat craniocerebral trauma at local county ICU, going into a coma wakes up for 5 days afterwards turns, and row " left tibia comminuted fracture expopexy ", postoperative right ancon, right Fracture of femur take a turn for the better, wound healing.Left leg is red and swollen, pain, ulceration sepage, gives extenal fixation and takes out, row " left tibia and fibula internal fixation of fracture ", postoperative wound is craniocerebral trauma improvement in 18 days in hospital still, proceeds to Chongqing Attached Hospital's hospitalization, is diagnosed as: 1, craniocerebral trauma 2, whole body multiple fracture after stable disease.Heavily doctor give " right elbow fracture internal fixation ", " right Fracture of femur internal fixation ".Local county people's hospital is gone back in 2014-04-30, hospitalization, the swelling always of left leg wound, pain, to suppurate, internal fixtion is taken out in 2014-05-04, postoperative wound still ulceration is suppurated, protracted course of disease so far, treat today my Out-patient Department for seeking medical advice, accept for medical treatment be admitted to hospital with " left tibia chronic osteomyelitis " by outpatient service.Training checks: vertebra physiological camber is normal, and flexion-extension motion is slightly limited, and left upper extremity is without exception, and a visible stringer 5cm surgical scars on rear side of right elbow joint, heal, right elbow joint bends and stretches limitation of activity.Right lower extremity atrophy, muscular tension is low, poor flexibility, and outside right thigh, visible an about 16cm has healed cicatrix, and heal, right hip joint, knee articulation are limited.Left lower extremity pain, amyotrophy, muscular tension is low, skin elasticity extreme difference, and obviously, on front side of left thigh stage casing visible about 10cm*10cm skin donor site, and surface has thicker crust to cover, mild pain for left ankle joint and left foot swelling.Several surgical scars visible on front side of left leg, inside left leg, a visible 1.5cm*2cm ulceration wound surface under knee joint, is shown in tibial exposure under wound surface, has a little pus to ooze out.In left leg, all the other places of epimere are dispersed in Semen Glycines size table shallow skin ulceration mouth as seen, see on rear side of left leg and be dispersed in pressure ulcer, a visible 3cm*5cm pressure ulcer on rear side of left ankle joint, pressure ulcer center ulceration, have a little sepage, left hip joint limitation of activity, left knee joint is tetanic is stretching 0 ° of position, left ankle joint is positioned at plantar flexion 40 ° of positions, movable poor.Left foot five toe activity calibration constant, two dorsal artery of foot can lay one's hand on and.Auxiliary examination: local county people's hospital 2013-08-30 DR shows: left tibia comminuted fracture is postoperative, and tibial plateau subsides, the visible screw in inner side is fixed, and tibia epimere is shown in that fracture of tibia is comminuted, and Density inhomogeneity, cortical bone density increases.In tibia, the visible screw of hypomere takes out rear cavity shadow.AD: left tibia chronic osteomyelitis.After 5 days, we have done one " the left tibia chronic osteomyelitis traditional Chinese medical science is followed through moving disease art " to patient and have taken out affected part sequestrum patient admits, allow sclerotin restoration ecosystem, fill local bony defect, medication after 2 months affected part ulcer surface reduce, swelling is gone down, and area of new bone is filled gradually, muscular tissue is had to creep, local drainage is unobstructed, and affected part skin temperature recovers normal, and color of the leather is ruddy.Patient medication was shown in after 6 months: affected part sclerotin is filled complete, and ulcer surface disappears, and local skin is dry, and healed surface is smooth, and surrounding skin is tending towards smooth, meets index of leaving hospital.

Embodiment 5, oral medicine formula: Herba Lepidogrammitis rostratae 20g, Folium Tagetis Erectae 20g, Radix Clematidis Argentilucidae 20g, Herba Senecionis nudicaulis 20g, flower of Radix Notoginseng 20g, Herba gentianae davidi 20g, Caulis et Folium (Gouaniae Leptostachyae) 20g, Cortex Linderae Obtusilobae 20g, Herba Clerodendri Serrati 20g, Herba Violae 20g, Herba Taraxaci 20g, Radix Berberidis 20g, Rhizoma Coptidis 10g, Flos Lonicerae 10g, Os Caprae seu Ovis 10g, Squama Manis 10g, Scolopendra 10g, Sanguis Draxonis 10g, Radix et Rhizoma Dysosmatis 10g, Radix Rhapontici 10g.

The dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

Usage and dosage: one day potion divides to be taken for three times.

Application compress formula: Herba gentianae davidi 30g, Lithargyrum 10g, catechu 30g, Momordica grosvenori root 30g, fibroferritum 10g, Folium Notoginseng 30g, Folium rosae multiflorae 30g, Herba Hedyotidis Diffusae 30g, Radix Actinidiae Chinensis 30g, Flos Tagetis Erectae root 30g, Herba Violae 30g, Sanguis Draxonis 30g, Scolopendra 30g, Herba Clerodendri Serrati 30g.

Application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.

Usage and dosage: subsides in a day, smear to affected part gauze and twine.

Model case:

Because wound causes " fl fracture " before 13 years, after local hospital capable " fl internal fixation of fracture " treatment, fracture heals, but left thigh occurs swelling pain repeatedly afterwards, at every turn remission after having a rest, so repeatedly so far.Again there is swelling pain in left thigh before more than February, and pain degree obviously increases the weight of than before, pain relief after vein anti-inflammatory treatment, but swelling still has, and has sense of discomfort during walking, and diagnosis is " fl chronic osteomyelitis ".Modern for asking further diagnosis and treatment, go to a doctor to my institute's Orthopaedics Clinic, outpatient service is intended " fl chronic osteomyelitis " and is hospitalized and be admitted to hospital.Training check: left thigh hypomere and left knee joint swelling obvious, outside left thigh, visible one is about 14cm old operative scar, local is kowtowed, tenderness is not obvious, and skin colour is partially dark, Pi Wenlvegao, poor flexibility, record left knee joint week footpath 36cm, left thigh hypomere week footpath 38cm, left thigh stage casing week footpath 41cm, left knee joint function activity is obviously limited, and the amyotrophy of left thigh part is obvious.Auxiliary examination: the attached First Hospital MRI of University Of Nanhua pointed out hypomere abnormal signal in left thigh on 01 02nd, 2014.X-ray inspection on the 02nd in 01 month in 2014 prompting fl hypomere bone density is uneven, and medullary cavity Density inhomogeneity shows.

Give drug oral of the present invention and external application for curing after 1 month: left thigh place wound surface reduces, and pus drain is unobstructed, local granulation tissue well-grown, color and luster is ruddy.Treat after 2 months: left thigh place wound surface is tending towards healing gradually, around incrustation, pus reduces gradually, and pus becomes Ovum Gallus domesticus album sample gradually by yellow, viscous, local granulation tissue well-grown, and color and luster is ruddy, and left knee joint movable function takes a turn for the better.Treat after 3 months: left thigh place wound healing, form scar tissue, local desiccation around, skin colour is ruddy, and left knee joint movable function takes a turn for the better.To leave hospital situation: patient leaves hospital through the clinical cure of 3 months, and patient and family members are very delight.

Pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Chinese medicine preparation of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of Chinese medicine preparation of the present invention and Chinese medicine preparation Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

clinical data

1 object and method

1.1 subject patient 200 examples, are divided into matched group 5O example at random, treatment group 150 example.

1.2 diagnostic criterias are with reference to osteomyelitis clinical manifestation.

1.3 aftertreatment method treatment groups: take medicinal preparation for oral administration of the present invention and Dressed plaster, matched group: oral antiinflammatory relieves the pain class tablet+massage+hot compress.

1.4 efficacy assessment standards (1) clinical recovery: clinical symptoms, sign disappear, follows up a case by regular visits to 3 months without recurrence.(2) effective: symptom obviously takes effect.(3) effective: clinical symptoms is slightly improved.(4) invalid: clinical symptoms, sign are without change.

I.5 statistical procedures uses SPSS 12.0 software to carry out statistical analysis, and ask that mean compares employing one factor analysis of variance for each group, group is asked and compared employing between two.Inspection.P<0.05 is that difference has significance.

2 results

Matched group recovery from illness 22 example, accounts for 44%; Effective 11 examples, account for 22%; Effective 8 examples, account for 16%; No effect 9, accounts for 18%, total effective rate 82%.

Treatment group recovery from illness 98 example, accounts for 65.33%; Effective 32 examples, account for 21.33%; Effective 15 examples, account for 10%; Invalid 5 examples, account for 3.33%.Total effective rate accounts for 96.66%.

Significance (P<O.05) is had through checking two groups of differences.

Claims (6)

1. the myelitic Chinese medicine composition for the treatment of, it is characterized in that, oral medicine is made up of the raw material of following weight portion: Herba Lepidogrammitis rostratae 10-20 part, Folium Tagetis Erectae 10-20 part, Radix Clematidis Argentilucidae 10-20 part, Herba Senecionis nudicaulis 10-20 part, flower of Radix Notoginseng 10-20 part, Herba gentianae davidi 10-20 part, Caulis et Folium (Gouaniae Leptostachyae) 10-20 part, Cortex Linderae Obtusilobae 10-20 part, Herba Clerodendri Serrati 10-20 part, Herba Violae 10-20 part, Herba Taraxaci 10-20 part, Radix Berberidis 10-20 part, Rhizoma Coptidis 1-10 part, Flos Lonicerae 1-10 part, Os Caprae seu Ovis 1-10 part, Squama Manis 1-10 part, Scolopendra 1-10 part, Sanguis Draxonis 1-10 part, Radix et Rhizoma Dysosmatis 1-10 part, Radix Rhapontici 1-10 part,

Application compress are made up of the raw material of following weight portion: Herba gentianae davidi 20-30 part, Lithargyrum 1-10 part, catechu 20-30 part, Momordica grosvenori root 20-30 part, fibroferritum 1-10 part, Folium Notoginseng 20-30 part, Folium rosae multiflorae 20-30 part, Herba Hedyotidis Diffusae 20-30 part, Radix Actinidiae Chinensis 20-30 part, Flos Tagetis Erectae root 20-30 part, Herba Violae 20-30 part, Sanguis Draxonis 20-30 part, Scolopendra 20-30 part, Herba Clerodendri Serrati 20-30 part.

2. one according to claim 1 treats myelitic Chinese medicine composition, it is characterized in that, oral medicine is made up of the raw material of following weight portion: Herba Lepidogrammitis rostratae 12-18 part, Folium Tagetis Erectae 12-18 part, Radix Clematidis Argentilucidae 12-18 part, Herba Senecionis nudicaulis 12-18 part, flower of Radix Notoginseng 12-18 part, Herba gentianae davidi 12-18 part, Caulis et Folium (Gouaniae Leptostachyae) 12-18 part, Cortex Linderae Obtusilobae 12-18 part, Herba Clerodendri Serrati 12-18 part, Herba Violae 12-18 part, Herba Taraxaci 12-18 part, Radix Berberidis 12-18 part, Rhizoma Coptidis 2-8 part, Flos Lonicerae 2-8 part, Os Caprae seu Ovis 2-8 part, Squama Manis 2-8 part, Scolopendra 2-8 part, Sanguis Draxonis 2-8 part, Radix et Rhizoma Dysosmatis 2-8 part, Radix Rhapontici 2-8 part,

Application compress are made up of the raw material of following weight portion: Herba gentianae davidi 22-28 part, Lithargyrum 2-8 part, catechu 22-28 part, Momordica grosvenori root 22-28 part, fibroferritum 2-8 part, Folium Notoginseng 22-28 part, Folium rosae multiflorae 22-28 part, Herba Hedyotidis Diffusae 22-28 part, Radix Actinidiae Chinensis 22-28 part, Flos Tagetis Erectae root 22-28 part, Herba Violae 22-28 part, Sanguis Draxonis 22-28 part, Scolopendra 22-28 part, Herba Clerodendri Serrati 22-28 part.

3. one according to claim 1 treats myelitic Chinese medicine composition, it is characterized in that, oral medicine is made up of the raw material of following weight portion: Herba Lepidogrammitis rostratae 15 parts, Folium Tagetis Erectae 15 parts, Radix Clematidis Argentilucidae 15 parts, Herba Senecionis nudicaulis 15 parts, flower of Radix Notoginseng 15 parts, Herba gentianae davidi 15 parts, Caulis et Folium (Gouaniae Leptostachyae) 15 parts, Cortex Linderae Obtusilobae 15 parts, Herba Clerodendri Serrati 15 parts, Herba Violae 15 parts, Herba Taraxaci 15 parts, Radix Berberidis 15 parts, Rhizoma Coptidis 5 parts, Flos Lonicerae 5 parts, Os Caprae seu Ovis 5 parts, Squama Manis 5 parts, Scolopendra 5 parts, Sanguis Draxonis 5 parts, Radix et Rhizoma Dysosmatis 5 parts, Radix Rhapontici 5 parts;

Application compress are made up of the raw material of following weight portion: Herba gentianae davidi 25 parts, Lithargyrum 5 parts, 25 parts, catechu, Momordica grosvenori root 25 parts, fibroferritum 5 parts, Folium Notoginseng 25 parts, Folium rosae multiflorae 25 parts, Herba Hedyotidis Diffusae 25 parts, Radix Actinidiae Chinensis 25 parts, Flos Tagetis Erectae root 25 parts, Herba Violae 25 parts, Sanguis Draxonis 25 parts, Scolopendra 25 parts, Herba Clerodendri Serrati 25 parts.

4. the one according to claim 1-3 any one treats myelitic Chinese medicine composition, it is characterized in that, the dosage form of endo-medicine preparation is honey refining pill, and its preparation method comprises:

(1) by formula proportion by Os Caprae seu Ovis, Squama Manis, that Scolopendra is ground into 300-400 order powder is for subsequent use;

(2) by formula proportion, surplus stock medicine is added the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, add powder for subsequent use, filter through 80-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, adds Mel and is twisted into pill.

5. the one according to claim 1-3 any one treats myelitic Chinese medicine composition, it is characterized in that, the dosage form of endo-medicine preparation is soup potus, and its preparation method comprises:

To add four times of water gagings after medicament mixed by formula proportion, after soaking half an hour, big fire changes slow fire into after boiling and simmers, and after 20 minutes, filtrate is for subsequent use, and medicinal residues continue to decoct with water 40 minutes waste filtrate, and twice filtrate merges, and obtains soup potus.

6. the one according to claim 1-3 any one treats myelitic Chinese medicine composition, it is characterized in that, application compress preparation method comprises:

(1) by formula proportion, each crude drug ovendry power is broken to 300-400 order powder for subsequent use;

(2) by formula proportion, powder for subsequent use is added Oleum Sesami to adjust all, obtain application compress.