CN104383175A - Medicine for treating chronic osteomyelitis and preparation method of medicine - Google Patents
Medicine for treating chronic osteomyelitis and preparation method of medicine Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a medicine for treating chronic osteomyelitis and a preparation method of the medicine, and belongs to the field of traditional Chinese medicines. Raw materials of effective components of the medicine comprise Japanese polygala, Japanese violet herb or root, humulus japonicus, cantonese ampelopsis, aeginetia indica, radix isatidis, eucommia ulmoides, araliaceae acanthopanax trifoliatus, abelmosk, cuneate lespedeza herb with root, wallich pepper stem and leaf, lamium amplexicaule, licorice, obscured homalomena rhizome, ambrosia artemisiifolia and elk's horn. The medicine is appropriate in compatibility, is prepared according to the property of the medicine to achieve the functions of treating both symptoms and root causes, promoting blood circulation, regulating vital energy, dispersing blood stasis and removing toxicity, is good in absorption effect, remarkable in treatment effect, safe, reliable and free from toxic and side effects and clinical adverse reaction, has the extremely good treatment effect on the chronic osteomyelitis, is capable of obviously improving the immunity of a human body, and can be widely applied to clinical treatment of the chronic osteomyelitis.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and the preparation method that are used for the treatment of chronic osteomyelitis.
Background technology
Chronic osteomyelitis is a kind of infection and destruction of bone, and by aerobic or anaerobe, mycobacteria and fungus cause.Chronic osteomyelitis is apt to occur in vertebra; The foot of diabetics or the penetrance bone injury site caused due to wound or operation.The most common site of child is that blood is for good long bone; As the metaphysis of tibia or femur.
Infect and caused (haematogenous chronic osteomyelitis) by haematogenous microorganism; From infected tissue's diffusion, comprise the infection of replacement joint, contaminative fracture and osseous surgery.Modal pathogen is gram positive bacteria.The microbial chronic osteomyelitis of Grain-negative is found in junkie, drepanocytemia patient and serious diabetes or traumatic patient.Fungus and mycobacterial infections person pathological changes are often confined to bone, and cause the chronic infection of Silent Neuritis.Risk factor comprises wasting diseases, radiotherapy, malignant tumor, diabetes, hemodialysis and intravenous administration.For child, anyly cause bacteremic process all may bring out chronic osteomyelitis.
Chronic osteomyelitis refers to that suppurative bacterium infects bone marrow, cortical bone and periosteum and the diseases associated with inflammation that causes, is mostly caused by haematogenous, is also manyly caused by wound or postoperative infection, how enters blood by the suppuration bacterium of furuncle carbuncle or other focuses and reaches osseous tissue.Bones of limbs two ends are subject to invade most, are the most common especially with hip joint.Common clinically have recurrent exerbation, has a strong impact on physical and mental health and work capacity.High heat, local pain during acute chronic osteomyelitis onset, have diabrosis, suppurate, have sequestrum or cavity to be formed when transferring chronic chronic osteomyelitis to.The normal threat to life of patient with severe symptoms, sometimes has to take the emergency approach of amputation, causes patient's lifelong disability.
The method of current treatment chronic osteomyelitis mainly based on operative treatment, focus is thoroughly removed, open spongy bone bone grafting and repeatedly rinse be Therapeutic Method the most frequently used at present.But there is risk in operative treatment, and surgery cost and height.Chinese medicine from the Nature, without toxicity, side effect, and instant effect.For this reason, we are badly in need of developing a kind of medicine and help patient and break away from the misery that chronic osteomyelitis brings.
Summary of the invention
The invention provides a kind of medicine and the preparation method that are used for the treatment of chronic osteomyelitis; Compatibility of drugs of the present invention is suitable, and concoct respectively according to the property of medicine, in the hope of the merit for the treatment of both the principal and secondary aspects of a disease, logical blood is regulated the flow of vital energy, the loose poison of blood stasis dispelling; Good absorbing effect, evident in efficacy, safe and reliable, have no side effect and clinical adverse, have fabulous curative effect to chronic chronic osteomyelitis, significantly improve the immunity of human body simultaneously, the clinical treatment of chronic osteomyelitis can be widely used in.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Be used for the treatment of a medicine for chronic osteomyelitis, raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Be used for the treatment of a preparation method for the medicine of chronic osteomyelitis, comprise following processing step:
(1) Herba Polygalae Japonicae, Radix Acanthopanacis Trifoliati, Caulis et Folium piperis, Rhizoma Homalomenae and Cornu Elaphuri pantotrichum are put into container, immerse 10 times amount volumetric concentration 70% alcohol solution dipping 4 hours, heating extraction, filter, after leaving standstill, reclaiming ethanol and being concentrated into 60 DEG C of relative densities is that the thick paste of 1.12-1.15 is for subsequent use;
(2) smash Herba Violae japonicae and Herba humuli scandentis to pieces strand juice, filter, stay juice for subsequent use;
(3) Radix Ampelopsis Cantoniensis, Radix Isatidis, Radix seu folium abelmoschi moschati, Herba Lespedezae Cuneatae, Herba Lamii Amplexicaulis, Radix Glycyrrhizae and Herba stachydis kouyangensis are put into container, add 10 times amount distilled water immersions after 4 hours, heated and boiled 4 hours, extract; Second time adds 8 times amount distilled water heated and boiled 3 hours, extracts; Third time adds 6 times amount distilled water heated and boiled 2 hours, extracts; Merge three gained extracting solution, filter, obtain filtrate for subsequent use;
(4) Herba aeginetiae indicae is cleaned, dry, grind into powder, cross 120 order fine powders, for subsequent use;
(5) first add certain amount of boiling water with Sal to dissolve, by Cortex Eucommiae block or strand, make fully to mix absorption with saline, then put in pot, frying with slow fire has focal spot degree of being to micro-, and taking-up is dried, and grinds into powder, crosses 160 order fine powders, for subsequent use;
(6) by thick paste obtained for step (1)-(5), juice, filtrate and fine powder mixing, make medicine, be the medicine being used for the treatment of chronic osteomyelitis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Polygalae Japonicae: bitter in the mouth, micro-pungent, property is put down; Return lung, stomach, heart channel.Promoting blood circulation to remove blood stasis, eliminating phlegm and relieving cough, removing toxic substances pain relieving.For pharyngitis, tonsillitis, stomatitis, cough, infantile pneumonia, infantile malnutrition, urinary system calculus, mastitis, chronic osteomyelitis; Venom is controlled in external, furuncle furuncle and phyma." Nanning City's medicine will " carries: " heat clearing away, moisturizes, removing toxic substances.Treating snakebite, cough, spits blood, infantile malnutrition, eye conjunctivitis.”
Herba Violae japonicae: bitter in the mouth, micro-pungent, cold in nature; Return liver, spleen channel.Heat-clearing and toxic substances removing, blood stasis dispelling evacuation of pus, removing heat from blood liver heat removing.Main swollen ulcer drug, acute mastitis, acute appendicitis hematochezia, suppurative chronic osteomyelitis, jaundice, conjunctival congestion and swelling pain, scrofula, traumatic hemorrhage, snakebite." Zhejiang conventional medical herbs among the people " carries: " heat clearing away, detumescence, removing toxic substances.”
Herba humuli scandentis: sweet in the mouth, hardship, cold in nature; Return lung, kidney channel.Heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome.Main cough due to lung-heat, lung abscess, deficiency-heat excessive thirst, pyretic stranguria, edema, dysuria, damp-heat dysentery, pathopyretic ulcer, skin pruritus." detailed outline " carries: " profit three is burnt, and disappear grain rice, beneficial the five internal organs, except nine worms, wards off pestilence, applies Serpentis, scorpion wound.”
Radix Ampelopsis Cantoniensis: acrid in the mouth, hardship, cool in nature; GUIXIN, spleen channel.Eliminating inflammation and expelling toxin, controls chronic osteomyelitis, acute lymphadenitis, acute mastitis, impetigo, eczema, erysipelas, furuncle and phyma, halophilic bacteria alimentary toxicosis." register planted by Guangxi medicine " carries: " root: detumescence poison.Herb: clearing away summer-heat heat.”
Herba aeginetiae indicae: bitter in the mouth, cool in nature; Slightly poisonous.Removing toxic substances and promoting subsidence of swelling, clearing away heat and cooling blood.For tonsillitis, pharyngolaryngitis, urinary tract infection, chronic osteomyelitis; Venom is controlled in external, furuncle.Soviet Union doctor " Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing.Treating tonsillitis, pharyngolaryngitis, urinary tract infection.”
Radix Isatidis: bitter in the mouth, cold in nature; Return liver, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood, controls influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, and pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash, and crimson tongue is purple dark, sore throat, scarlet fever, major part pestilence, carbuncle; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, chronic osteomyelitis can be prevented and treated." Chinese medicinal herbal " carries: " Qinghuo Jiedu, cooling blood for hemostasis.Control calentura and send out speckle, erysipelas, laryngopharynx swelling and pain, epidemic infection with swollen head, and the disease such as haematemesis, epistaxis.”
The Cortex Eucommiae: sweet in the mouth, micro-pungent, warm in nature; Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Main spinal column ache, sexual impotence, frequent micturition, dribbling urination, rheumatic arthralgia, frequent fetal movement, habitual abortion." beautiful Chinese catalpa medicine solution " carries: " liver and kidney tonifying, nourishing muscle and tendon bone go to joint to wet excessive, control soreness of waist and knee joint, the contracture of lower limb foot.”
Radix Acanthopanacis Trifoliati: bitter in the mouth, pungent, cool in nature.Heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Main cold, fever, pharyngalgia, headache, cough chest pain, gastralgia, has loose bowels, dysentery, hypochondriac pain, jaundice, stranguria caused by urinary stone, leukorrhagia, rheumatic arthralgia, and the contracture of waist and leg ache ， le bone is numb, injury and bone fracture, mumps, acute mastitis, sore swollen toxin, snake bite and insect sting.
Radix seu folium abelmoschi moschati: taste is micro-sweet, cold in nature; GUIXIN, lung meridian.Heat-clearing and toxic substances removing, stimulating milk secretion relieving constipation.Main hyperpyrexia, cough due to lung-heat, dysentery, constipation, puerperal, galactostasis, fractured, carbuncle skin ulcer abscess, and innominate toxic swelling and water inflammation are scalded." Guangxi Chinese herbal medicine " carries: " removing toxic substances and promoting subsidence of swelling, evacuation of pus pain relieving.Control carbuncle skin ulcer to swell and ache, innominate toxic swelling, carbuncle of the nape.”
Herba Lespedezae Cuneatae: bitter in the mouth, puckery, cool in nature; Return lung, liver, kidney channel.The kidney invigorating arresting seminal emission, invigorating spleen to remove dampness, supplements phlegm and relieving cough, heat-clearing and toxic substances removing.Master suffers from a deficiency of the kidney, and seminal emission, the enuresis, frequent micturition, nebulousurine, leukorrhagia, has loose bowels, dysentery, edema, infantile malnutrition, cough and asthma, traumatic injury, conjunctival congestion and swelling pain, carbuncle pyogenic infections from tumour or sore, insect-bite." east, Fujian book on Chinese herbal medicine " carries: " lung moistening, yin nourishing, the liver benefiting, nourishing kidney.Control nyctalopia, night sweat, seminal emission, lumbago." modern medicine study confirms; herb decoct all has bacteriostasis in more than 6.25-25% concentration to staphylococcus aureus, Diplococcus pneumoniae, first streptococcus and micrococcus catarrhalis; 707 every milliliter containing more than 5mg; have inhibitory action to Staphylococcus albus, have inhibitory action containing more than 10mg to first streptococcus.
Caulis et Folium piperis: acrid in the mouth, sweet, warm in nature; Return liver, spleen, small intestine meridian.Wind-damp dispelling, strong waist knee joint, kidney invigorating and YANG supporting, relieving cough and asthma, promoting blood circulation and stopping pain.Main anemofrigid-damp arthralgia, soreness of waist and knee joint, sexual impotence, cough and asthma, dysmenorrhea, treating swelling and pain by traumatic injury." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " control the muscle and tendon injury of cold-damp numbness, dispel the wind, bones and muscles pain, diuresis and pains in the penis, pyretic stranguria from the beginning of, diuresis is rapidly.”
Herba Lamii Amplexicaulis: acrid in the mouth, hardship, slightly warm in nature.Promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling.Main traumatic injury, bones and muscles pain, numb limbs and tense tendons, hemiplegia, face is completed, jaundice, nasal sinusitis, scrofula, toxic swelling, impetigo." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " control muscles and bones phlegm-fire pain, numb hand and foot is meciless.To dispel the wind of whole body migration, loose scrofula brothers sucutaneous nodule.Control traumatic injury, synthetism.Only sinusitis with purulent discharge nasal sinusitis, bag phlegm-fire congestion and swelling pain.”
Radix Glycyrrhizae: sweet in the mouth, property is put down; Return spleen, stomach, the heart, lung meridian.QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis." medicineization justice " carries: " Radix Glycyrrhizae, raw with cool and pathogenic fire purging, main loose pathogenic factor in the exterior, subduing inflammation, sore-throat relieving pain, separates hundred poison of drug, except stomach accumulated heat, goes urinary catheter pain, and the power of this sweet cool heat extraction also.Process the invigorating middle warmer by temperature, main insufficiency of the spleen cunning is rushed down, and insufficiency of stomach is thirsty, and cold and heat are coughed, and breathe hard sleepy, forced labour is deficient, and this sweet temperature helps the merit of spleen also.But rich and too sweet, unsuitable multiplex in tonic, probably love diaphragm does not think food yet.”
Rhizoma Homalomenae: bitter in the mouth, pungent, warm in nature; Mild toxicity; Return liver, kidney, stomach warp.Wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving, detumescence.Main air pain of dampness syndrome, podomere acid is educated, and muscles and bones flaccidity is soft, traumatic injury, stomachache, and carbuncle skin ulcer swells." decoction pieces is newly joined " carries: " enter blood system, wind-damp dispelling arthralgia pain, bone and muscle strengthening, control podomere ache.”
Herba stachydis kouyangensis: lightly seasoned, micro-hardship, cool in nature; Return spleen, heart channel.Eliminating inflammation and expelling toxin, evacuation of pus.Cure mainly furuncle, chronic osteomyelitis." Yunnan Chinese herbal medicine " carries: " eliminating inflammation and expelling toxin is drawn out the pus.Control furuncle, chronic osteomyelitis, mash deposited affected part with fresh grass.”
Cornu Elaphuri pantotrichum: sweet in the mouth, warm in nature; Return kidney channel.Kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, strong waist knee joint.Main asthenia is won thin, asthenia of essence and blood, and sexual impotence is infertile, soreness of the waist and knees, bones and muscles pain." book on Chinese herbal medicine is looked for the truth " carries: " though elk, deer point have two, so always fill up marrow, strong muscles and bones outward, long qi and blood invigorating and be tonifying liver nourishing kidney key medicine also.”
The present invention compared with prior art, has following beneficial effect:
Compatibility of drugs of the present invention is suitable, and concoct respectively according to the property of medicine, in the hope of the merit for the treatment of both the principal and secondary aspects of a disease, logical blood is regulated the flow of vital energy, the loose poison of blood stasis dispelling; Good absorbing effect, evident in efficacy, safe and reliable, have no side effect and clinical adverse, have fabulous curative effect to chronic chronic osteomyelitis, significantly improve the immunity of human body simultaneously, the clinical treatment of chronic osteomyelitis can be widely used in.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
The processing step of process for preparing medicine of the present invention is:
(1) Herba Polygalae Japonicae, Radix Acanthopanacis Trifoliati, Caulis et Folium piperis, Rhizoma Homalomenae and Cornu Elaphuri pantotrichum are put into container, immerse 10 times amount volumetric concentration 70% alcohol solution dipping 4 hours, heating extraction, filter, after leaving standstill, reclaiming ethanol and being concentrated into 60 DEG C of relative densities is that the thick paste of 1.12-1.15 is for subsequent use;
(2) smash Herba Violae japonicae and Herba humuli scandentis to pieces strand juice, filter, stay juice for subsequent use;
(3) Radix Ampelopsis Cantoniensis, Radix Isatidis, Radix seu folium abelmoschi moschati, Herba Lespedezae Cuneatae, Herba Lamii Amplexicaulis, Radix Glycyrrhizae and Herba stachydis kouyangensis are put into container, add 10 times amount distilled water immersions after 4 hours, heated and boiled 4 hours, extract; Second time adds 8 times amount distilled water heated and boiled 3 hours, extracts; Third time adds 6 times amount distilled water heated and boiled 2 hours, extracts; Merge three gained extracting solution, filter, obtain filtrate for subsequent use;
(4) Herba aeginetiae indicae is cleaned, dry, grind into powder, cross 120 order fine powders, for subsequent use;
(5) first add certain amount of boiling water with Sal to dissolve, by Cortex Eucommiae block or strand, make fully to mix absorption with saline, then put in pot, frying with slow fire has focal spot degree of being to micro-, and taking-up is dried, and grinds into powder, crosses 160 order fine powders, for subsequent use;
(6) by thick paste obtained for step (1)-(5), juice, filtrate and fine powder mixing, make medicine, be the medicine being used for the treatment of chronic osteomyelitis of the present invention.
Usage and dosage: oral, every day 3 times, each 27 days is a course for the treatment of, and the lighter can fully recover 2 to 4 courses for the treatment of, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of chronic osteomyelitis, select the routine clinical observation of chronic osteomyelitis patient 100 that my institute or outer court make a definite diagnosis, patient is divided into two groups at random, treatment group 50 example, wherein male 25 example, women 25 example, age 27-76 year, 45 years old mean age, the course of disease 6 months-17 years; Matched group 50 example, wherein male 25 example, women 25 example, age 26-66 year, 48 years old mean age, the course of disease 6 months-17 years.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes medicine of the present invention, every day 3 times, each 2, and warm water delivery service in half an hour after meal 7 days is a course for the treatment of, and taking 2 to 4 courses for the treatment of continuously can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes osteitis spirit sheet, and by specification use, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: general pain, become thin, fatigue, heating, lumbago and backache, periosteal reaction, bone marrow damage, erythrocyte sedimentation rate speed, refer to the transference cures such as toe-end mummification necrosis, physical recovery is normal.
(2) effective: above-mentioned symptom is alleviated to some extent.
(3) invalid: disease is unchanged.
4, result:
Take in the treatment group of medicine of the present invention, cure 38 examples, effective 9 examples, invalid 3 examples, cure rate is 76%, total effective rate 94%.
Cure 10 examples in matched group, effective 19 examples, invalid 21 examples, cure rate is 20%, total effective rate 58%.
Above result display, treatment group cure rate and total effective rate are apparently higher than matched group.
5, model case citing:
(1), Huang, man, 68 years old, retired worker, people from Baoding.Patient's readme arm, leg joint swell and ache, and left lower limb knee joint bottom is red and swollen, and slightly namely ulceration causes the prolonged ulcer do not healed, and broken skin ulcer is suppurated, and tenderness sense is strong, long-term disunion.Repeatedly attempt drug for diminishing inflammation and antibiosis treatment, recurrent exerbation, once dropped out fritter sequestrum before 3 years, and swollen joint increases slightly, existing lopsided symptom, and walking sitting and lying loses capacity of will.To our hospital, be diagnosed as: osteomyelitis.After take 4 courses for the treatment of of medicine of the present invention after, pain disappears, and suffering limb activity freely, is followed up a case by regular visits to and do not recurred, and thoroughly cures.
(2), ten thousand certain, man, 30 years old, teacher, people from Guangan, Sichuan.This patient, because of traumatic injury unexpected on school sports, causes elbow joint congestion and swelling pain, does not prolongedly heal.Subperiosteal abscess is diagnosed as, Soft Tissue Abscess: An Experimental by X-ray film.Through antibacterial therapy after a while, effect is not remarkable, and pain is aggravated.Then to our hospital, then on the basis that it continues intravenous injection anti-inflammation, be aided with medicine of the present invention.After taking 2 courses for the treatment of of medicine of the present invention, pick body, continue to take medicine 3 of the present invention course for the treatment of, above-mentioned symptom disappears, and follows up a case by regular visits to and does not recur, thoroughly cure.
(3), Ma, female, 32 years old, civil servant, Quanzhou, Fujian people.Patient's left tibia and fibula osteomyelitis 5 years, treats at local hospital, does not take a favorable turn always.Introduce through friend, carry out my institute's treatment.After taking 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom takes a turn for the better, and after continuing to take 2 courses for the treatment of of medicine of the present invention, health is fully recovered, and follows up a case by regular visits to and does not recur.
(4), Liu, man, 59 years old, peasant, people from Ji'an, Jiangxi.Patient was in 5 years cause left foot outside clavuss, after corn plaster treatment ulceration, there is symptom that is red and swollen, that have a little yellow watery transudate to ooze out, due to the impaired medical history of spinal nerves, have no pain and affect function, once arriving many large hospital diagnosis and treatment, mainly with oral anti-inflammatory drug, medicated powder external application, the treatment such as to change dressings, less effective, form wound and do not heal for a long time, the local skin colour of skin is deepened.Namely arrive me institute to go to a doctor, be diagnosed as osteomyelitis.After take 3 courses for the treatment of of medicine of the present invention after, above-mentioned symptom alleviates, and continue to take 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom all disappears, and follows up a case by regular visits to and does not recur, and thoroughly cures.
(5), Wang, man, 37 years old, retired worker, Tianshui city people.Patient causes compound injury because of vehicle accident, and left lower extremity is to above knee amputation, and right leg is with open fracture, and wound of going out is frustrated in skin dirt, row bone grafting internal fixtion, and postoperative wound surface infects, repeated multiple times fixing all failed at local urgent disorder in orthopaedics hospital operation bone grafting.Introduce my institute by local hospital orthopedics expert and accept treatment.After take 2 courses for the treatment of of medicine of the present invention after, above-mentioned symptom takes a turn for the better, and after continuing to take 2 courses for the treatment of of medicine of the present invention, health is fully recovered, and follows up a case by regular visits to and does not recur.
(6), Shen, female, 45 years old, certain enterprise retired veteran cadre, people from yan-an.Patient's 1 year front right lower jaw is had a toothache and within 2nd, is namely occurred that right angle of mandible, cheek and right neck epimere are red and swollen, pain, actions such as feed of dehiscing are limited, and namely treat at local hospital, after a few days, symptom has no improvement, the difficulty in opening mouth that swells and ache on the contrary exacerbation of symptoms, then to our hospital.After take 3 courses for the treatment of of medicine of the present invention, above-mentioned symptom takes a turn for the better, and after continuing to take 2 courses for the treatment of of medicine of the present invention, health is fully recovered, and follows up a case by regular visits to and does not recur.
Claims (5)
1. be used for the treatment of a medicine for chronic osteomyelitis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Polygalae Japonicae 25-49 part Herba Violae japonicae 23-48 part Herba humuli scandentis 21-45 part Radix Ampelopsis Cantoniensis 21-45 part
Herba aeginetiae indicae 18-43 part Radix Isatidis 17-41 part Cortex Eucommiae 17-41 part Radix Acanthopanacis Trifoliati 16-36 part
Radix seu folium abelmoschi moschati 16-36 part Herba Lespedezae Cuneatae 15-33 part Caulis et Folium piperis 15-33 part Herba Lamii Amplexicaulis 13-31 part
Radix Glycyrrhizae 13-28 part Rhizoma Homalomenae 12-25 part Herba stachydis kouyangensis 11-23 part Cornu Elaphuri pantotrichum 8-18 part.
2. a kind of medicine being used for the treatment of chronic osteomyelitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Polygalae Japonicae 43 portions of Herba Violae japonicaes 41 parts of Herba humuli scandentis 39 parts of Radix Ampelopsis Cantoniensiss 39 parts
Herba aeginetiae indicae 36 parts of Radix Isatidis 35 parts of Cortexs Eucommiae 35 parts of Radix Acanthopanacis Trifoliatis 31 parts
Radix seu folium abelmoschi moschati 31 portions of Herba Lespedezae Cuneatae 28 parts of Caulis et Folium piperis 28 parts of Herba Lamii Amplexicauliss 26 parts
Radix Glycyrrhizae 24 parts of Rhizoma Homalomenaes 21 parts of Herba stachydis kouyangensiss 20 parts of Cornu Elaphuri pantotrichum 15 parts.
3. a kind of medicine being used for the treatment of chronic osteomyelitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Polygalae Japonicae 37 portions of Herba Violae japonicaes 35 parts of Herba humuli scandentis 33 parts of Radix Ampelopsis Cantoniensiss 33 parts
Herba aeginetiae indicae 30 parts of Radix Isatidis 29 parts of Cortexs Eucommiae 29 parts of Radix Acanthopanacis Trifoliatis 26 parts
Radix seu folium abelmoschi moschati 26 portions of Herba Lespedezae Cuneatae 24 parts of Caulis et Folium piperis 24 parts of Herba Lamii Amplexicauliss 22 parts
Radix Glycyrrhizae 21 parts of Rhizoma Homalomenaes 18 parts of Herba stachydis kouyangensiss 17 parts of Cornu Elaphuri pantotrichum 13 parts.
4. a kind of medicine being used for the treatment of chronic osteomyelitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Herba Polygalae Japonicae 31 portions of Herba Violae japonicaes 29 parts of Herba humuli scandentis 27 parts of Radix Ampelopsis Cantoniensiss 27 parts
Herba aeginetiae indicae 24 parts of Radix Isatidis 23 parts of Cortexs Eucommiae 23 parts of Radix Acanthopanacis Trifoliatis 21 parts
Radix seu folium abelmoschi moschati 21 portions of Herba Lespedezae Cuneatae 20 parts of Caulis et Folium piperis 20 parts of Herba Lamii Amplexicauliss 18 parts
Radix Glycyrrhizae 18 parts of Rhizoma Homalomenaes 15 parts of Herba stachydis kouyangensiss 14 parts of Cornu Elaphuri pantotrichum 11 parts.
5. the preparation method being used for the treatment of the medicine of chronic osteomyelitis as described in claim 1-5, is characterized in that: comprise following processing step:
(1) Herba Polygalae Japonicae, Radix Acanthopanacis Trifoliati, Caulis et Folium piperis, Rhizoma Homalomenae and Cornu Elaphuri pantotrichum are put into container, immerse 10 times amount volumetric concentration 70% alcohol solution dipping 4 hours, heating extraction, filter, after leaving standstill, reclaiming ethanol and being concentrated into 60 DEG C of relative densities is that the thick paste of 1.12-1.15 is for subsequent use;
(2) smash Herba Violae japonicae and Herba humuli scandentis to pieces strand juice, filter, stay juice for subsequent use;
(3) Radix Ampelopsis Cantoniensis, Radix Isatidis, Radix seu folium abelmoschi moschati, Herba Lespedezae Cuneatae, Herba Lamii Amplexicaulis, Radix Glycyrrhizae and Herba stachydis kouyangensis are put into container, add 10 times amount distilled water immersions after 4 hours, heated and boiled 4 hours, extract; Second time adds 8 times amount distilled water heated and boiled 3 hours, extracts; Third time adds 6 times amount distilled water heated and boiled 2 hours, extracts; Merge three gained extracting solution, filter, obtain filtrate for subsequent use;
(4) Herba aeginetiae indicae is cleaned, dry, grind into powder, cross 120 order fine powders, for subsequent use;
(5) first add certain amount of boiling water with Sal to dissolve, by Cortex Eucommiae block or strand, make fully to mix absorption with saline, then put in pot, frying with slow fire has focal spot degree of being to micro-, and taking-up is dried, and grinds into powder, crosses 160 order fine powders, for subsequent use;
(6) by thick paste obtained for step (1)-(5), juice, filtrate and fine powder mixing, make medicine, be the described medicine being used for the treatment of chronic osteomyelitis.
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| CN104984059A (en) * | 2015-06-19 | 2015-10-21 | 张士海 | External preparation for treating osteomyelitis and preparing method |
| CN104997950A (en) * | 2015-06-19 | 2015-10-28 | 张士海 | External paste agent for treating pyogenic osteomyelitis and preparation method thereof |
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| CN103520439A (en) * | 2013-10-17 | 2014-01-22 | 赵永东 | Traditional Chinese medicine for treating heat-toxicity accumulation type chronic osteomyelitis and preparation method thereof |
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| CN103520439A (en) * | 2013-10-17 | 2014-01-22 | 赵永东 | Traditional Chinese medicine for treating heat-toxicity accumulation type chronic osteomyelitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104984059A (en) * | 2015-06-19 | 2015-10-21 | 张士海 | External preparation for treating osteomyelitis and preparing method |
| CN104997950A (en) * | 2015-06-19 | 2015-10-28 | 张士海 | External paste agent for treating pyogenic osteomyelitis and preparation method thereof |
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Application publication date: 20150304 |