CN104997950A - External paste agent for treating pyogenic osteomyelitis and preparation method thereof - Google Patents
External paste agent for treating pyogenic osteomyelitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an external paste agent for treating pyogenic osteomyelitis. The external paste agent is mainly prepared from the following bulk drugs by mass: 10 to 16 parts of equisetum, 5 to 9 parts of Acer palmatum Thunb., 9 to 13 parts of Gentiana davidii Franch., 7 to 16 parts of Rhododendron delavayi Franch., 10 to 14 parts of Viola japonica Langsd., 8 to 15 parts of Rabdosia coetsa, 9 to 14 parts of root of Canton Ampelopsis, 4 to 7 parts of herb of Soda-apple Nightshade, 6 to 10 parts of Schisandra propinqua, 9 to 12 parts of Erigeron breviscapus, 11 to 15 parts of isatis root, 8 to 14 parts of root-bark of Spinystem Aralia, 6 to 13 parts of Japanese milkwort herb, 9 to 16 parts of twig and leaf of Manyflower Supplejack and 7 to 12 parts of Ficus pandurata Hance. The external paste agent is prepared on the basis of a summary of clinical practice of many years, is capable of eliminating swelling, removing toxic matters, clearing heat and relieving pain and has substantial curative effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the myelitic externally used paste of a kind of therapeutic purulence and method for making.
Background technology
Suppurative osteomyelitis is the inflammation being caused osseous tissue by pyogenic baeceria.Pathogen is mainly staphylococcus aureus, and being secondly group B streptococcus, Staphylococcus albus, is escherichia coli, streptococcus pneumoniae, bacillus pyocyaneus, hemophilus influenza etc. once in a while.Route of infection has haematogenous, spreading property and traumatic.Haematogenous person pathogenic bacteria is from focus is through hematogenous infection in bone at a distance, and be apt to occur in the metaphysis of long bone, form abscess, diffuse to form subperiosteal abscess, enter pulp cavity again through Haversian canal through cortical bone, blocking-up blood fortune, forms sequestrum.This disease is apt to occur in childhood, and male is more.Pathological development is fast, destructive large.Early manifestation is hyperpyrexia, osteodynia and tenderness; Late period is formed for suffering from district's inflammatory reaction, swelling and abscess.It is dense poly-that nuclide examination can see lesion medicine for 24 hours in morbidity.X-ray sheet just can see focus in morbidity after 10 days, within 4 weeks, could determine sequestrum.Leukocyte increases, erythrocyte sedimentation rate is accelerated, hemoculture, locally puncture are got pus cultivation and contributed to making a definite diagnosis.
The Chinese patent literature of publication No. CN 104667207 A (application number 201310605435.4) discloses the myelitic Chinese medicine composition of a kind of therapeutic purulence, described formula forms by following weight: Herba Ephedrae 3-7 gram, Semen Sinapis Albae 4-8 gram, carbonized Rhizoma Zingiberis (processed) 6-10 gram, Fructus Amomi 8-12 gram, Radix Codonopsis 13-17 gram, Rhizoma Atractylodis Macrocephalae 16-20 gram, Herba speranskiae tuberculatae 18-22 gram, Squama Manis 7-11 gram.The Chinese patent literature of publication No. CN 103893208 A (application number 201210575730.5) discloses a kind of preparation method for the treatment of Acute osteomyelitis unguentum, adopts following steps: step one, to be fired by the cattle bone slow fire of 500g; Step 2, the charcoal described in step one is ground to form cattle bone smalls; Step 3, the cattle bone smalls described in step 2 crossed hundred mesh sieves screenings; Step 4, the cattle bone smalls 100g leaf fat described in step 3 is mixed well paste making agent; Step 5, the unguentum external application that step 4 mixed up are at inflammation place.The Chinese patent literature of publication No. CN 103585502 A (application number 201310558707.X) discloses the myelitic Chinese medicinal effective-part composition of a kind of therapeutic purulence.Chinese medicine composition of the present invention is raw material by the Radix Paeoniae Alba, Partition in Fructus Juglandis, Herba Salviae Chinensis, Ramulus Euonymi, Semen Momordicae and Succus Bambusae, forms according to certain parts by weight.
The treatment of this disease is at present mainly antibiotic and operative treatment, costly, the scope of application is little, the course for the treatment of is long, and treatment by Chinese herbs to have side effect little, effective advantage, the state of an illness, indiffusion can be stablized, part Chinese medicine formula Clinical Practice, therapeutic effect is poor, therefore needs the formula working out Be very effective.
Summary of the invention
For the problem of prior art, the object of this invention is to provide the wide myelitic externally used paste of therapeutic purulence of a kind of Be very effective, the use safety suitability and method for making.
Technical scheme of the present invention is:
The myelitic externally used paste of a kind of therapeutic purulence, is prepared from primarily of following bulk drugs, is mass parts: Herba Equiseti Hiemalis 10-16; Acer palmatum 5-9; Herba gentianae davidi 9-13; Flos Rhododendri Delavayi 7-16; Herba Violae japonicae 10-14; Broken orchid root 8-15; Radix Ampelopsis Cantoniensis 9-14; Soda-apple nightshade herb 4-7; Radix seu Caulis Schisandrae Sinensis 6-10; Herba Erigerontis 9-12; Radix Isatidis 11-15; Cortex Araliae Echinocaulis Radicis 8-14; Herba Polygalae Japonicae 6-13; Ramulus et folium berchemiae floribundae 9-16; Radix fici panduratae 7-12.
Preferred version is, Herba Equiseti Hiemalis 12-14; Acer palmatum 6-8; Herba gentianae davidi 10-12; Flos Rhododendri Delavayi 9-14; Herba Violae japonicae 11-13; Broken orchid root 10-13; Radix Ampelopsis Cantoniensis 10-13; Soda-apple nightshade herb 5-6; Radix seu Caulis Schisandrae Sinensis 7-9; Herba Erigerontis 10-11; Radix Isatidis 12-14; Cortex Araliae Echinocaulis Radicis 10-12; Herba Polygalae Japonicae 8-11; Ramulus et folium berchemiae floribundae 11-14; Radix fici panduratae 8-11.
More preferably, Herba Equiseti Hiemalis 13; Acer palmatum 7; Herba gentianae davidi 11; Flos Rhododendri Delavayi 11.5; Herba Violae japonicae 12; Broken orchid root 11.5; Radix Ampelopsis Cantoniensis 11.5; Soda-apple nightshade herb 5.5; Radix seu Caulis Schisandrae Sinensis 8; Herba Erigerontis 10.5; Radix Isatidis 13; Cortex Araliae Echinocaulis Radicis 11; Herba Polygalae Japonicae 9.5; Ramulus et folium berchemiae floribundae 12.5; Radix fici panduratae 9.5.
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, step is as follows:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 8-16 minute (preferably: soak 10-14 minute; Be more preferably: soak 12 minutes), take out, be placed in constant temperature drying in baking box, smash to pieces, add fine salt and mix thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 20-30 minute (preferably: water proof heating 22-28 minute; Be more preferably: water proof heats 25 minutes), take out, dry in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 6-18 minute, takes out, and pulverizes and sieves, make medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add vinegar water soaking 15 minutes, big fire is heated to boiling, turns little fire and decocts, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into thick paste, adds adjuvant, stirs, make externally used paste.
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, the amount that step (1) adds fine salt is that the 0.3-0.6 of Flos Rhododendri Delavayi quality is doubly (preferred: the amount adding fine salt is 0.4-0.5 times of Flos Rhododendri Delavayi quality; Be more preferably: the amount adding fine salt is 0.45 times of Flos Rhododendri Delavayi quality).
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, step (3) slow fire stir-fries 9-15 minute (being more preferably: slow fire stir-fries 12 minutes).
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, it is (preferred: to pulverize 120-180 mesh sieve that step (3) pulverized 100-200 mesh sieve; Be more preferably: pulverized 150 mesh sieves).
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, it is doubly (preferred: to add 7-8 times that the vinegar water yield is boiled crude drug quality that step (4) adds the 6-9 that the vinegar water yield is boiled crude drug quality; Be more preferably: add 7.5 times that the vinegar water yield is boiled crude drug quality).
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, step (4) turns little fire and decocts 30-44 minute (preferably: turn little fire and decoct 34-40 minute; Be more preferably: turn little fire and decoct 37 minutes).
The preparation method of the described myelitic externally used paste of a kind of therapeutic purulence, it is (preferred: heating is concentrated into the thick paste that relative density is 1.18-1.24 that step (5) heating is concentrated into the thick paste (75 DEG C) that relative density is 1.14-1.28; Be more preferably: heating is concentrated into the thick paste that relative density is 1.21).
The myelitic externally used paste scientific formulation of the therapeutic purulence of one provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, effectively can shorten treatment time;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of subduing swelling and detoxicating, clearing away heat to alleviate pain;
3, Chinese crude drug selected by the present invention, safety has no side effect, and the efficacy of a drug directly acts on affected part, Be very effective.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Equiseti Hiemalis: base is former: be the herb of Equisetaceae plant Herba Equiseti Hiemalis.Nature and flavor: sweetness and bitterness are flat.Gui Jing: enter lung, liver, gallbladder meridian.Function cures mainly: wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, nebula removing.Control the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, dysentery, de-liver, malaria, laryngalgia, carbuncle.
Acer palmatum: base is former: be branch, the leaf of Aceraceae plant Acer palmatum.Chemical analysis: leaf contains Du Jingsu, saponarin, orientin, matched moulds orientin, cyanidin monoglycoside, delphinidin monosaccharide glycoside, peonidin monosaccharide glycoside.Nature and flavor: pungent; Micro-hardship; Flat.Function cures mainly: promoting the circulation of QI to relieve pain; Removing toxicity for eliminating carbuncles.Main abdominal pain due to stagnation of QI; Carbuncle carbuncle on the back.
Herba gentianae davidi: base is former: be the wounded in the battle herb of gentianaceae plant Five Ridges Radix Gentianae.Nature and flavor: bitter; Cold in nature.Gui Jing: liver; Wing takes off warp.Function cures mainly: heat-clearing and toxic substances removing; Dampness removing.Main infantile convulsion; Conjunctival congestion; Pharyngalgia; Hepatitis; Dysentery; Stranguria; Suppurative osteomyelitis; Carbuncle pyogenic infections from tumour or sore; Venom.
Flos Rhododendri Delavayi: base is former: be the flower of ericad Flos Rhododendri Delavayi.Nature and flavor: bitter; Cool in nature; Mild toxicity.Gui Jing: liver; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main osteomyelitis; Digestive tract hemorrhage; Spitting of blood; Epistaxis; Metrorrhagia; Menoxenia.
Herba Violae japonicae: base is former: be the herb of Violaceae plant lobus cardiacus common violet.Nature and flavor: bitter in the mouth; Micro-pungent; Cold in nature.Gui Jing: liver; Spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Blood stasis dispelling evacuation of pus; Removing heat from blood liver heat removing.Main swollen ulcer drug; Acute mastitis; Acute appendicitis hematochezia; Suppurative osteomyelitis; Jaundice; Conjunctival congestion and swelling pain; Scrofula; Traumatic hemorrhage; Snakebite.
Broken orchid root: base is former: be the root of labiate Rabdosia coesta.Nature and flavor: bitter in the mouth; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Promoting blood circulation and stopping pain.Main jaundice due to damp-heat; The pain over the hypochondriac region; Traumatic pain.
Radix Ampelopsis Cantoniensis: base is former: be root or the Herb of vitaceae Caulis seu folium ampelopsis brevipedunculatae in Guangdong.Nature and flavor: pungent; Bitter; Cool.Gui Jing: the heart; Spleen channel.Function cures mainly: removing dampness of dispeling the wind; Heat-clearing and toxic substances removing.Main summer catches a cold; Rheumatic arthralgia; Swollen ulcer drug; Eczema eczema.
Soda-apple nightshade herb: base is former: be the Herb of plant of Solanaceae cattle Fructus Solani melongenae.Nature and flavor: bitter in the mouth; Pungent; Slightly warm in nature; Poisonous.Function cures mainly: antitussive and antiasthmatic; Eliminating stasis to stop pain.Main chronic bronchitis; Asthma; Stomachache; Rheumatalgia lumbago and skelalgia; Scrofula; Cold pus infections; Carbuncle sore tumefacting virus; Traumatic injury.
Radix seu Caulis Schisandrae Sinensis: base is former: be ratan or the root of Schisandraceae Plant Cortex cynoglossi zeylanici radicis.Nature and flavor: pungent; Warm in nature.Function cures mainly: expelling wind and activating blood circulation; Removing toxic substances and promoting subsidence of swelling; Hemostasis.Main rheumatic numbness; Bones and muscles pain; Traumatic injury; Menoxenia; Stomachache; Abdominal distention; Carbuncle sore tumefacting virus; Over-strained hemoptysis.
Herba Erigerontis: base is former: be root and the herb of feverfew Erigeron breviscapus (Vant.) Hand.-Mazz..Nature and flavor: acrid in the mouth; Micro-hardship; Temperature.Gui Jing: return lung; Stomach; Tripe warp.Function cures mainly: expelling cold and relieving exterior syndrome; Expelling wind and removing dampness; Activating collaterals to relieve pain; Removing food stagnancy.Main flu; Rheumatic arthralgia; Paralysis; Stomachache; Toothache; Infantile malnutrition; Osteomyelitis; Traumatic injury.
Radix Isatidis: base is former: be the root of crucifer ancient name for Chinese cabbage basket and careless Folium Isatidis; Or the rhizome of acanthaceous vegetable acanthaceous indigo and root.Nature and flavor with return through, bitter, cold.GUIXIN, stomach warp.There is heat-clearing and toxic substances removing, effect of removing heat from blood sore-throat relieving.For pestilence seasonal noxious pathogen, heating pharyngalgia, maculae caused by violent heat pathogen, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle.
Cortex Araliae Echinocaulis Radicis: base is former: be root and the root bark of Araliaceae Ji Jing Cortex araliae chinensis.Nature and flavor: mildly bitter flavor; Pungent; Property is put down.Function cures mainly: expelling wind and removing dampness; Blood-activating and qi-promoting; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Treating swelling and pain by traumatic injury; Fracture; Epigastric distending pain; Hernia; Metrorrhagia; Osteomyelitis; Carbuncle; Venom.
Herba Polygalae Japonicae: base is former: be herb or the root of milk wort Herba Polygalae Japonicae.Chemical analysis: root is containing triterpenoid saponin, resin, fatty oil, polygalytol.Nature and flavor: bitter in the mouth; Micro-pungent; Property is put down.Gui Jing: lung; Stomach; Heart channel.Expelling phlegm for arresting cough; Dissipating blood stasis stops blooding; Mind tranquilizing and the heart calming; Removing toxic substances and promoting subsidence of swelling.Main cough with copious phlegm; Traumatic injury, rheumatic arthralgia; Spit blood; Have blood in stool; Cardiopalmus; Insomnia; Laryngopharynx swelling and pain; Carbuncle skin infection; Venom.
Ramulus et folium berchemiae floribundae: base is former: for Rhamnaceae plant spends more the stem of Radix Berchemiae Giraldianae, leaf or root.Nature and flavor: sweet; Puckery; Tepor.Gui Jing: liver; Gallbladder meridian.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Stomachache; Dysmenorrhea; Puerperal abdonimal pain; Traumatic injury; Tuberculosis of bone and joint; Osteomyelitis; Infantile malnutrition; Hepatitis; Liver cirrhosis.
Radix fici panduratae: base is former: be root, the leaf of moraceae plants Radix fici panduratae.Nature and flavor: sweet in the mouth, micro-pungent, property are put down.Function cures mainly: expelling wind and removing dampness; Removing toxic substances and promoting subsidence of swelling; Promoting blood circulation to restore menstrual flow.Main air pain of dampness syndrome; Yellow cellulitis; Malaria; Pertussis; Galactostasis; Acute mastitis; Dysmenorrhea; Amenorrhea; Carbuncle furuncle and phyma pain; Traumatic injury; Venom.
Embodiment 1 one kinds of myelitic externally used pastes of therapeutic purulence, are prepared from (every part of 10g) primarily of following bulk drugs: Herba Equiseti Hiemalis 10 parts, Acer palmatum 5 parts, Herba gentianae davidi 9 parts, Flos Rhododendri Delavayi 7 parts, Herba Violae japonicae 10 parts, broken orchid root 8 parts, Radix Ampelopsis Cantoniensis 9 parts, soda-apple nightshade herb 4 parts, Radix seu Caulis Schisandrae Sinensis 6 parts, Herba Erigerontis 9 parts, Radix Isatidis 11 parts of Cortex Araliae Echinocaulis Radicis 8 parts, Herba Polygalae Japonicae 6 parts, Ramulus et folium berchemiae floribundae 9 parts, Radix fici panduratae 7 parts.The preparation method of the myelitic externally used paste of above-mentioned a kind of therapeutic purulence is:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 8 minutes, take out, be placed in constant temperature drying in baking box, smash to pieces, the fine salt adding 0.3 times of Flos Rhododendri Delavayi quality is mixed thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 20 minutes, takes out, dries in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 6 minutes, takes out, and pulverized 100 mesh sieves, and made medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add the vinegar water soaking 15 minutes of boiled crude drug quality 6 times, big fire is heated to boiling, turns little fire and decocts 30 minutes, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into the thick paste (75 DEG C) that relative density is 1.14, adds adjuvant, stirs, make externally used paste.
Embodiment 2 one kinds of myelitic externally used pastes of therapeutic purulence, are prepared from (every part of 10g) primarily of following bulk drugs: Herba Equiseti Hiemalis 16 parts, Acer palmatum 9 parts, Herba gentianae davidi 13 parts, Flos Rhododendri Delavayi 16 parts, Herba Violae japonicae 14 parts, broken orchid root 15 parts, Radix Ampelopsis Cantoniensis 14 parts, soda-apple nightshade herb 7 parts, Radix seu Caulis Schisandrae Sinensis 10 parts, Herba Erigerontis 12 parts, Radix Isatidis 15 parts of Cortex Araliae Echinocaulis Radicis 14 parts, Herba Polygalae Japonicae 13 parts, Ramulus et folium berchemiae floribundae 16 parts, Radix fici panduratae 12 parts.The preparation method of the myelitic externally used paste of above-mentioned a kind of therapeutic purulence is:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 16 minutes, take out, be placed in constant temperature drying in baking box, smash to pieces, the fine salt adding 0.6 times of Flos Rhododendri Delavayi quality is mixed thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 30 minutes, takes out, dries in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 18 minutes, takes out, and pulverized 200 mesh sieves, and made medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add the vinegar water soaking 15 minutes of boiled crude drug quality 9 times, big fire is heated to boiling, turns little fire and decocts 44 minutes, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into the thick paste (75 DEG C) that relative density is 1.28, adds adjuvant, stirs, make externally used paste.
Model case: xxx, male, 14 years old.Main suit: the gonalgia, red and swollen, with high heat shiver with cold; Medical history: patient's three days presensation discomforts, fever with aversion to cold, body temperature is increased to 38.6 DEG C then, the gonalgia, stiff, swelling is obvious, accompanies through household, go to examination in hospital, number of white blood cells increases, and erythrocyte sedimentation rate is accelerated, and blood bacterial culture is positive, periosteum puncture can extract pus out, is diagnosed as suppurative osteomyelitis.
Use this example gained externally used paste, first use normal saline flushing, then uniform application is in affected part; with gauze parcel, one day twice 15 days is a course for the treatment of; after patient uses five days, fever with aversion to cold phenomenon disappears, and arthroncus phenomenon alleviates; adhere to that use is after one month, patients symptomatic is clearly better, after continuing a course for the treatment of of use; joint function recovery is normal, can normal activity, through check; uncomfortable disease is all eliminated, and indices all recovers normal.
Embodiment 3 one kinds of myelitic externally used pastes of therapeutic purulence, are prepared from (every part of 10g) primarily of following bulk drugs: Herba Equiseti Hiemalis 12 parts, Acer palmatum 6 parts, Herba gentianae davidi 10 parts, Flos Rhododendri Delavayi 9 parts, Herba Violae japonicae 11 parts, broken orchid root 10 parts, Radix Ampelopsis Cantoniensis 10 parts, soda-apple nightshade herb 5 parts, Radix seu Caulis Schisandrae Sinensis 7 parts, Herba Erigerontis 10 parts, Radix Isatidis 12 parts of Cortex Araliae Echinocaulis Radicis 10 parts, Herba Polygalae Japonicae 8 parts, Ramulus et folium berchemiae floribundae 11 parts, Radix fici panduratae 8 parts.The preparation method of the myelitic externally used paste of above-mentioned a kind of therapeutic purulence is:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 10 minutes, take out, be placed in constant temperature drying in baking box, smash to pieces, the fine salt adding 0.4 times of Flos Rhododendri Delavayi quality is mixed thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 22 minutes, takes out, dries in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 9 minutes, takes out, and pulverized 120 mesh sieves, and made medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add the vinegar water soaking 15 minutes of boiled crude drug quality 7 times, big fire is heated to boiling, turns little fire and decocts 34 minutes, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into the thick paste (75 DEG C) that relative density is 1.18, adds adjuvant, stirs, make externally used paste.
Model case: xxx, women, 47 years old.Medical history: patient must have suppurative osteomyelitis half a year, and symptom is red swollen feet, rough surface, and sclerotin thickens, and oozes out with purulent secretion, and wound can not heal for a long time, once takes antibacterials, DeGrain, recurrent exerbation, seeks tcm methods treatment then.
Through this example of people's recommendation gained externally used paste, first use normal saline flushing, then uniform application is in affected part, with gauze parcel, one day twice 15 days is a course for the treatment of, after patient uses a course for the treatment of, uncomfortable disease obviously alleviates, after adhering to three courses for the treatment of of use, ooze out without purulent secretion, function of joint is recovered substantially, on inspection, sinus tract mouth heals, joint repair, and patient fully recovers, follow up a case by regular visits in 1 year, the state of an illness does not recur.
Embodiment 4 one kinds of myelitic externally used pastes of therapeutic purulence, are prepared from (every part of 10g) primarily of following bulk drugs: Herba Equiseti Hiemalis 14 parts, Acer palmatum 8 parts, Herba gentianae davidi 12 parts, Flos Rhododendri Delavayi 14 parts, Herba Violae japonicae 13 parts, broken orchid root 13 parts, Radix Ampelopsis Cantoniensis 13 parts, soda-apple nightshade herb 6 parts, Radix seu Caulis Schisandrae Sinensis 9 parts, Herba Erigerontis 11 parts, Radix Isatidis 14 parts of Cortex Araliae Echinocaulis Radicis 12 parts, Herba Polygalae Japonicae 11 parts, Ramulus et folium berchemiae floribundae 14 parts, Radix fici panduratae 11 parts.The preparation method of the myelitic externally used paste of above-mentioned a kind of therapeutic purulence is:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 14 minutes, take out, be placed in constant temperature drying in baking box, smash to pieces, the fine salt adding 0.5 times of Flos Rhododendri Delavayi quality is mixed thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 28 minutes, takes out, dries in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 15 minutes, takes out, and pulverized 180 mesh sieves, and made medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add the vinegar water soaking 15 minutes of boiled crude drug quality 8 times, big fire is heated to boiling, turns little fire and decocts 40 minutes, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into the thick paste (75 DEG C) that relative density is 1.24, adds adjuvant, stirs, make externally used paste.
Embodiment 5 one kinds of myelitic externally used pastes of therapeutic purulence, are prepared from (every part of 10g) primarily of following bulk drugs: Herba Equiseti Hiemalis 13 parts, Acer palmatum 7 parts, Herba gentianae davidi 11 parts, Flos Rhododendri Delavayi 11.5 parts, Herba Violae japonicae 12 parts, broken orchid root 11.5 parts, Radix Ampelopsis Cantoniensis 11.5 parts, soda-apple nightshade herb 5.5 parts, Radix seu Caulis Schisandrae Sinensis 8 parts, Herba Erigerontis 10.5 parts, Radix Isatidis 13 parts of Cortex Araliae Echinocaulis Radicis 11 parts, Herba Polygalae Japonicae 9.5 parts, Ramulus et folium berchemiae floribundae 12.5 parts, Radix fici panduratae 9.5 parts.The preparation method of the myelitic externally used paste of above-mentioned a kind of therapeutic purulence is:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 12 minutes, take out, be placed in constant temperature drying in baking box, smash to pieces, the fine salt adding 0.45 times of Flos Rhododendri Delavayi quality is mixed thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 25 minutes, takes out, dries in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 12 minutes, takes out, and pulverized 150 mesh sieves, and made medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add the vinegar water soaking 15 minutes of boiled crude drug quality 7.5 times, big fire is heated to boiling, turns little fire and decocts 37 minutes, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into the thick paste (75 DEG C) that relative density is 1.21, adds adjuvant, stirs, make externally used paste.
The clinical practice of a kind of myelitic externally used paste of therapeutic purulence (embodiment 5) of test example 1 gained of the present invention:
Choose crowd: in April ,-2015 in May, 2014, according to medical case history, patient 267 example of suppurative osteomyelitis is diagnosed as five hospital's screenings, age 6-68 year, 31.4 ± 2.7 years old mean age, male patient 164 example, female patient 103 example, wherein Acute osteomyelitis patient 186 example, chronic suppurative osteomyelisis patient 81 example.Its clinical manifestation: onset is hurried, general malaise, shiver with cold, high heat, xerostomia, yellow and greasy fur, slippery and rapid pulse etc.Sick lower limb vein severe pain, from the beginning of time color unrestrained swollen in vain, the micro-red heating of color of the leather after 1-2 days, fat swollen bone is swollen, passes local inflammation in time more obvious; X-ray checks, soft tissue swelling, lacks unity and coherence, and onset, after two weeks, is shown in the metaphysis spongy bone of skeleton and occurs osteoporosis, then forms multiple irregular worm and bites the little bone destruction district of shape, visible periosteal reaction around cortical bone.
Before test, patient is divided into two groups at random, experimental group 179 example and matched group 88 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, first uses normal saline flushing, then uniform application is in affected part, and with gauze parcel, one day twice 15 days is a course for the treatment of; Matched group adopts other conventional methods (antibiotic therapy, operative treatment etc.).Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: clinical symptoms and partial gall disappear, suffering limb functional rehabilitation, and x-ray display sclerotin is normal, wound healing; (2) effective: clinical symptoms and partial gall disappear, suffering limb functional rehabilitation, x-ray display bone destruction part is repaired; (3) effective: clinical symptoms and sign all take a favorable turn, x-ray display bone destruction is repaired gradually, and focus is stablized; (4) invalid: the treatment front and back state of an illness is unchanged or increase the weight of.
Clinical effectiveness: after the treatment of four courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the healing patient of experimental group is 117 examples, and cure rate is 65.4%, and effective patient is 32 examples, obvious effective rate is 17.9%, effective patient is 26 examples, and effective percentage is 14.5%, and total effective rate is 97.8%, and the total effective rate 80.7% of matched group, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The Chinese medicine used in the present invention, comprise the Herba Equiseti Hiemalis of wind-dispelling heat-dissipating, the Acer palmatum of removing toxicity for eliminating carbuncles, the Herba gentianae davidi of heat-clearing and toxic substances removing, Radix Ampelopsis Cantoniensis, Radix Isatidis, the Flos Rhododendri Delavayi of cooling blood for hemostasis, the Herba Violae japonicae of blood stasis dispelling evacuation of pus, the broken orchid root of clearing away heat-damp and promoting diuresis, the soda-apple nightshade herb of eliminating stasis to stop pain, the Radix seu Caulis Schisandrae Sinensis, Cortex Araliae Echinocaulis Radicis of removing toxic substances and promoting subsidence of swelling, Herba Polygalae Japonicae, the Herba Erigerontis of activating collaterals to relieve pain, Ramulus et folium berchemiae floribundae, the Radix fici panduratae of promoting blood circulation to restore menstrual flow, multiple medical material synergism, plays effect of removing toxicity for eliminating carbuncles, clearing away heat to alleviate pain altogether, effectively diminish inflammation, cure suppurative osteomyelitis.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. the myelitic externally used paste of therapeutic purulence, is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Herba Equiseti Hiemalis 10-16; Acer palmatum 5-9; Herba gentianae davidi 9-13; Flos Rhododendri Delavayi 7-16; Herba Violae japonicae 10-14; Broken orchid root 8-15; Radix Ampelopsis Cantoniensis 9-14; Soda-apple nightshade herb 4-7; Radix seu Caulis Schisandrae Sinensis 6-10; Herba Erigerontis 9-12; Radix Isatidis 11-15; Cortex Araliae Echinocaulis Radicis 8-14; Herba Polygalae Japonicae 6-13; Ramulus et folium berchemiae floribundae 9-16; Radix fici panduratae 7-12.
2. the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 1, is characterized in that, Herba Equiseti Hiemalis 12-14; Acer palmatum 6-8; Herba gentianae davidi 10-12; Flos Rhododendri Delavayi 9-14; Herba Violae japonicae 11-13; Broken orchid root 10-13; Radix Ampelopsis Cantoniensis 10-13; Soda-apple nightshade herb 5-6; Radix seu Caulis Schisandrae Sinensis 7-9; Herba Erigerontis 10-11; Radix Isatidis 12-14; Cortex Araliae Echinocaulis Radicis 10-12; Herba Polygalae Japonicae 8-11; Ramulus et folium berchemiae floribundae 11-14; Radix fici panduratae 8-11.
3. the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 1, it is characterized in that, Herba Equiseti Hiemalis 13; Acer palmatum 7; Herba gentianae davidi 11; Flos Rhododendri Delavayi 11.5; Herba Violae japonicae 12; Broken orchid root 11.5; Radix Ampelopsis Cantoniensis 11.5; Soda-apple nightshade herb 5.5; Radix seu Caulis Schisandrae Sinensis 8; Herba Erigerontis 10.5; Radix Isatidis 13; Cortex Araliae Echinocaulis Radicis 11; Herba Polygalae Japonicae 9.5; Ramulus et folium berchemiae floribundae 12.5; Radix fici panduratae 9.5.
4. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Flos Rhododendri Delavayi drip washing clean, be placed in meter Shui Zhong and soak 8-16 minute (preferably: soak 10-14 minute; Be more preferably: soak 12 minutes), take out, be placed in constant temperature drying in baking box, smash to pieces, add fine salt and mix thoroughly;
(2) get Acer palmatum, Ramulus et folium berchemiae floribundae and Radix fici panduratae and clean remove impurity, cut into slices or section, add refined honey water and mix thoroughly, be placed in steamer, water proof heats 20-30 minute (preferably: water proof heating 22-28 minute; Be more preferably: water proof heats 25 minutes), take out, dry in the air cool;
(3) by step (1) (2) made crude drug, be placed in parch container, slow fire stir-fries 6-18 minute, takes out, and pulverizes and sieves, make medicated powder with the Herba Equiseti Hiemalis of clean dry, Herba gentianae davidi, Herba Violae japonicae together with Herba Erigerontis;
(4) by broken orchid root, Radix Ampelopsis Cantoniensis, soda-apple nightshade herb, Radix seu Caulis Schisandrae Sinensis, Radix Isatidis, Cortex Araliae Echinocaulis Radicis and Herba Polygalae Japonicae removing impurity, clean, be placed in non iron container, add vinegar water soaking 15 minutes, big fire is heated to boiling, turns little fire and decocts, filtering and collecting filter liquid, filtering residue adds water and again decocts, and after filtration, merges twice gained filtrate;
(5) by step (3) (4) gained medicated powder and filtrate mixing, heating is concentrated into thick paste, adds adjuvant, stirs, make externally used paste.
5. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 4, it is characterized in that, the amount that step (1) adds fine salt is that the 0.3-0.6 of Flos Rhododendri Delavayi quality is doubly (preferred: the amount adding fine salt is 0.4-0.5 times of Flos Rhododendri Delavayi quality; Be more preferably: the amount adding fine salt is 0.45 times of Flos Rhododendri Delavayi quality).
6. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 4, is characterized in that, step (3) slow fire stir-fries 9-15 minute (being more preferably: slow fire stir-fries 12 minutes).
7. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 4, is characterized in that, it is (preferred: to pulverize 120-180 mesh sieve that step (3) pulverized 100-200 mesh sieve; Be more preferably: pulverized 150 mesh sieves).
8. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 4, it is characterized in that, it is doubly (preferred: to add 7-8 times that the vinegar water yield is boiled crude drug quality that step (4) adds the 6-9 that the vinegar water yield is boiled crude drug quality; Be more preferably: add 7.5 times that the vinegar water yield is boiled crude drug quality).
9. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 4, is characterized in that, step (4) turns little fire and decocts 30-44 minute (preferably: turn little fire and decoct 34-40 minute; Be more preferably: turn little fire and decoct 37 minutes).
10. the preparation method of the myelitic externally used paste of a kind of therapeutic purulence as claimed in claim 4, it is characterized in that, it is (preferred: heating is concentrated into the thick paste that relative density is 1.18-1.24 that step (5) heating is concentrated into the thick paste that relative density is 1.14-1.28; Be more preferably: heating is concentrated into the thick paste that relative density is 1.21).
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Non-Patent Citations (2)
| Title |
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| 曾一林: "化脓性骨髓炎的中医药治疗", 《成都中医药大学学报》 * |
| 郑晓辉等: "中草药犁头草内服外敷对慢性骨髓炎临床疗效的影响", 《广州中医药大学学报》 * |
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Application publication date: 20151028 |